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    4219 results match your criteria Henoch-Schonlein Purpura Anaphylactoid Purpura

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    Henoch Schönlein Purpura Nephritis Associated with Intravesical Bacillus Calmette-Guerin (BCG) Therapy.
    Intern Med 2017 1;56(5):541-544. Epub 2017 Mar 1.
    Department of Nephrology, Showa General Hospital, Japan.
    Henoch Schönlein purpura (HSP), also known as IgA vasculitis (IgAV), is a systemic small-vessel vasculitis that predominantly affects adolescents and is rare in adults. In many cases, the onset of HSP has been causally linked to an infectious disease. We encountered a case of HSP with severe renal involvement diagnosed by renal biopsy following bacillus Calmette-Guerin (BCG) therapy for bladder cancer. Read More

    [Comparison of age-based clinical and abnormal immune parameters in patients with Henoch-Schönlein purpura].
    Zhonghua Xue Ye Xue Za Zhi 2017 Jan;38(1):60-64
    Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.
    Objective: To explore age-based clinical and immune parameters in Henoch-Schönlein purpura (HSP) to determine clinically useful markers reflecting disease characteristic. Methods: A cohort of 502 patients with HSP were enrolled into this retrospective study to evaluate their clinical and immune data. Results: Majority HSP cases occurred at age ≤14 years and showed significant immune imbalances of ESR, CD3(+) cells, CD4(+) cells, CD3(-)CD16(+)CD56(+) cells, CD4(+)/CD8(+) cells, IgG, IgA, IgM, IgE, complements C3/C4 and ASO in the acute phase. Read More

    A Case of Henoch-Schonlein Purpura Associated with Rotavirus Infection in an Elderly Asian Male and Review of the Literature.
    Am J Case Rep 2017 Feb 8;18:136-142. Epub 2017 Feb 8.
    Department of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
    BACKGROUND Henoch-Schönlein purpura (HSP), a small vessel vasculitis mediated by deposition of immune-complexes containing IgA in the skin, gut, and glomeruli, often presents with abdominal pain, purpuric rash in the lower extremities and buttocks, joint pain, and hematuria. The disease most commonly targets children but can affect adults who tend to have a worse prognosis. CASE REPORT We discuss a case of HSP in an elderly Chinese male who presented with severe proximal bowel inflammation, vasculitic rash, and proteinuria; he was found to have positive stool rotavirus and giardia. Read More

    Multicentric Castleman's disease associated with IgA vasculitis (Henoch-Schönlein purpura) responding well to tocilizumab: a case report.
    Clin Rheumatol 2017 Mar 6;36(3):729-733. Epub 2017 Feb 6.
    Nephrology Center, Toranomon Hospital, 2-2-2, Toranomon, Minato, Tokyo, 105-8470, Japan.
    A 41-year-old man was referred to our hospital for the evaluation of hypergammaglobulinemia (IgG 2898 mg/dL and IgA 587 mg/dL), inflammation (CRP 6.7 mg/dL and serum interleukin-6 (IL-6) 15.1 ng/L), and anemia (Hb 10. Read More

    Henoch-Schönlein purpura as a rare cause of an acute abdomen.
    Ann R Coll Surg Engl 2017 Feb 4;99(2):e88-e90. Epub 2017 Jan 4.
    Lancashire Teaching Hospitals NHS Foundation Trust , UK.
    A 52-year-old man presented with a purpuric rash affecting his legs and hypertension. He was diagnosed with Henoch-Schönlein purpura and discharged with non-steroidal anti-inflammatory drugs. Three weeks later, he presented again with loss of appetite and vomiting before developing abdominal pain with pyrexia of 38. Read More

    [IgA vasculitis (Henoch-Schönlein purpura)].
    Wiad Lek 2016;69(5):711-713
    Katedra i Klinika Nefrologii, Dializoterapii i Chorób Wewnętrznych WUM, Warszawa, Polska.
    IgA vasculitis (Schönlein-Henoch purpura) is a systemic inflammation of the small vessels associated with the deposition of IgA antibodies in the vascular wall. Typical clinical symptoms are: skin lesions (purpura), joint pain, abdominal discomfort and renal disorder (most common haematuria/proteinuria). The disease affects usually the pediatric population; in those patients its course is benign and usually not associated with permanent complications. Read More

    Rare urological manifestation of Henoch-Schönlein purpura: testicular torsion.
    BMJ Case Rep 2016 Nov 11;2016. Epub 2016 Nov 11.
    Department of Urology, Maxima Medisch Centrum, Eindhoven, The Netherlands.
    The Henoch-Schönlein purpura (HSP) is a systemic vasculitis that mostly occurs in children. Besides the most common clinical manifestations such as palpable purpura, arthralgia, abdominal pain and renal disease, it can have urological manifestations. We report a rare case of a 2-year-old boy with the HSP who developed a testicular torsion under corticosteroid treatment. Read More

    Staphylococcus Infection-Associated GN - Spectrum of IgA Staining and Prevalence of ANCA in a Single-Center Cohort.
    Clin J Am Soc Nephrol 2017 Jan 7;12(1):39-49. Epub 2016 Nov 7.
    Department of Pathology, and.
    Background And Objectives: Staphylococcus infection-associated GN (SAGN) is a well recognized disease entity, particularly because of the frequent IgA-dominant glomerular immunoglobulin staining on kidney biopsy. Biopsy features can resemble two other disease entities - primary IgA nephropathy and Henoch-Schönlein purpura nephritis - posing a diagnostic pitfall. This is clinically relevant because of the crucial difference in the therapeutic approach. Read More

    Histopathological and immunological changes during the acute and recovery phase in Henoch-Schönlein purpura rabbit model.
    Arch Dermatol Res 2017 Jan 21;309(1):21-30. Epub 2016 Oct 21.
    Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Beijing, People's Republic of China.
    Henoch-Schönlein purpura (HSP) is a systemic vasculitis mediated by autologous immune complex. Animal models of HSP are scarce. Here, we describe the characteristics of HSP rabbit model in the acute and recovery phase. Read More

    Differences in pathological characteristics and laboratory indicators in adult and pediatric patients with Henoch-Schönlein purpura nephritis.
    J Huazhong Univ Sci Technolog Med Sci 2016 Oct 18;36(5):659-666. Epub 2016 Oct 18.
    Department of Nephrology, the First Hospital of Jilin University, Changchun, 130021, China.
    We aimed to investigate the differences in renal histopathological changes and laboratory parameters between adult and pediatric patients with Henoch-Schönlein purpura nephritis (HSPN), and to analyze the correlation between laboratory parameters and renal histopathological grading. A total of 139 patients diagnosed with HSPN between September 2010 and December 2014 at the First Hospital of Jilin University, China, were retrospectively reviewed. The clinical and pathological characteristics were examined and compared between the adult and the pediatric patients. Read More

    [Clinical effect of gamma globulin pulse therapy for abdominal Henoch-Schönlein purpura in children].
    Zhongguo Dang Dai Er Ke Za Zhi 2016 Oct;18(10):988-990
    Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan 430060, China.
    Objective: To study the clinical effect of high-dose gamma globulin pulse therapy for abdominal Henoch-Schönlein purpura (HSP).

    Methods: Thirty-three children with abdominal HSP were randomly assigned to dexamethasone group (15 children) and gamma globulin group (18 children). The children in the dexamethasone group were treated with dexamethasone and conventional treatment, and those in the gamma globulin group were treated with high-dose gamma globulin pulse therapy in addition to the conventional treatment. Read More

    Recurrent adult onset Henoch-Schonlein Purpura: a case report.
    Dermatol Online J 2016 08 15;22(8). Epub 2016 Aug 15.
    Department of Pathology, Weill Cornell Medicine, New York.
    Henoch-Schonlein purpura is an immunoglobulin A (IgA)-immune complex mediated leukocytoclastic vasculitis that classically manifests with palpable purpura, abdominal pain, arthritis, and hematuria or proteinuria. The condition is much more predominant in children (90% of cases) and commonly follows an upper respiratory infection. We present a case of recurrent Henoch-Schonlein purpura (HSP) complicated by nephritis in an adult female initially categorized as IgA nephropathy (IgAN). Read More

    [Henoch-Schönlein purpura in a cocaine consumer man with HIV infection and ANCA-p positivity].
    Medicina (B Aires) 2016;76(4):245-8
    Centro Sanatorio Delta, Rosario, Santa Fe, Argentina.
    The Henoch-Schönlein purpura (HSP) is a small vessel vasculitis with IgA immune complex deposition. The presentation in adults is rare and severe. Reported cases of HSP in patients infected with HIV are scarce. Read More

    Circulating midkine in children with Henoch-Schönlein purpura: Clinical implications.
    Int Immunopharmacol 2016 Oct 3;39:246-50. Epub 2016 Aug 3.
    Pediatric Research Institute, Qilu Children's Hospital of Shandong University, Ji'nan 250022, China. Electronic address:
    Background: Midkine (MK) is a heparin-binding growth factor, which behaves like a cytokine, involved in various cellular processes such as cellular proliferation, differentiation, survival, adhesion, and migration. Studies provided evidence for a role of MK in acute and chronic inflammatory processes. The association between midkine and Henoch-Schönlein purpura (HSP) has not yet been explored. Read More

    Henoch-Schönlein purpura from vasculitis to intestinal perforation: A case report and literature review.
    World J Gastroenterol 2016 Jul;22(26):6089-94
    Butsabong Lerkvaleekul, Soamarat Vilaiyuk, Division of Rheumatology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
    Henoch-Schönlein purpura (HSP) is generally a self-limited vasculitis disease and has a good prognosis. We report a 4-year-old Thai boy who presented with palpable purpura, abdominal colicky pain, seizure, and eventually developed intestinal ischemia and perforation despite adequate treatment, including corticosteroid and intravenous immunoglobulin therapy. Imaging modalities, including ultrasonography and contrast-enhanced computed tomography, could not detect intestinal ischemia prior to perforation. Read More

    No impairment of pulmonary function in children with Henoch-Schonlein purpura after 4-year follow-up.
    Clin Rheumatol 2016 Nov 27;35(11):2847-2850. Epub 2016 Jul 27.
    Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, Mazowiecka 6/8, 92-215, Lodz, Poland.
    Henoch-Schonlein purpura (HSP) is a generalized form of IgA-mediated vasculitis that usually spares pulmonary circulation. Nevertheless, it is conceivable that subclinical changes at the HSP onset may lead to lung impairment in the long term. Therefore, we decided to follow a group of HSP patients for 4 years to monitor changes in pulmonary function. Read More

    Henoch-Schönlein purpura associated with Strongyloides stercoralis infection.
    Vojnosanit Pregl 2016 May;73(5):491-5
    Introduction: Henoch-Schönlein purpura (HSP) is a small blood vessel vasculitis, which usually manifests during childhood. The exact cause of the disease is unknown.

    Case Report: We reported a 14-year-old girl who had been admitted to our clinic due to the appearance of red macules on her extremities and face, vomiting, and pain in the abdomen and joints. Read More

    Relapses in patients with Henoch-Schönlein purpura: Analysis of 417 patients from a single center.
    Medicine (Baltimore) 2016 Jul;95(28):e4217
    aDivision of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria bDivision of Internal Medicine, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria cDivision of Pathology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria dDivision of Pediatrics, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria eDivision of Dermatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain.
    To further investigate into the relapses of Henoch-Schönlein purpura (HSP), we analyzed the frequency, clinical features, and predictors of relapses in series of 417 unselected patients from a single center. After a median follow-up of 12 (interquartile range [IQR]: 2-38) years, almost one-third of the 417 patients (n = 133; 32%; 85 men/48 women) had experienced at least 1 relapse. At the time of disease diagnosis, patients who later experienced relapses had less commonly infections than those who never suffered flares (30. Read More

    [Association of Cosmc gene mutation with susceptibility to Henoch-Schönlein purpura in children].
    Zhongguo Dang Dai Er Ke Za Zhi 2016 Jul;18(7):625-9
    Department of Rheumatology, Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.
    Objective: To investigate the presence of Cosmc gene mutation in children with Henoch-Schönlein purpura (HSP) and the association between Cosmc gene mutation and the susceptibility to HSP.

    Mesults: Eighty-four children who were diagnosed with HSP between March 2014 and December 2015 were selected as the HSP group. Fifty-eight healthy volunteers matched for age and sex were enrolled as the control group. Read More

    [Abdominal symptoms necessitating surgical intervention as the initial presentation of Henoch-Schönlein purpura in children - case reports].
    Pol Merkur Lekarski 2016 Jun;40(240):377-9
    Department of Pediatrics and Nephrology, Medical University of Warsaw.
    Unlabelled: Henoch-Schönlein purpura (HSP) is the most common pediatric autoimmune vasculitis. Gastrointestinal symptoms of HSP including abdominal pain, diarrhea, and vomiting may precede skin changes by several days. We present diagnostic challenges in two adolescents with HSP and severe abdominal symptoms necessitating surgical intervention before the development of skin changes. Read More

    Henoch-Schönlein without Purpura: A Case Report and Review Literature.
    J Med Assoc Thai 2016 Apr;99(4):441-5
    Henoch-Schönlein purpura (HSP) is a multi-organ vasculitis involving skin, joints, gastrointestinal tract, and kidneys. The present study reported a 5-year-old boy presenting with intense abdominal pain, bloody diarrhea, and protein-losing enteropathy. Investigations for infectious enteritis were negative. Read More

    Azathioprine therapy for steroid-resistant Henoch-Schönlein purpura: a report of 6 cases.
    Pediatr Rheumatol Online J 2016 Jun 23;14(1):37. Epub 2016 Jun 23.
    Department of Pediatrics, Division of Rheumatology, Washington University School of Medicine, One Children's Place, Campus Box 8116, St. Louis, MO, 63110, USA.
    Background: A small percentage of children with Henoch-Schönlein purpura (HSP) develop a chronic form of the disease that often requires prolonged corticosteroid therapy. Disease modifying anti-rheumatic agents (DMARDs) or biologics have been successfully used to treat those refractory cases. Azathioprine is a DMARD that has been reported to be effective in HSP nephritis and in adult cutaneous leukocytoclastic vasculitis, a condition with cutaneous histology similar to HSP. Read More

    [Significance of detection of biomarker fecal bile acids in the diagnosis and treatment of childhood Henoch-Schönlein purpura].
    Zhongguo Dang Dai Er Ke Za Zhi 2016 Jun;18(6):517-21
    Department of Pediatrics, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.
    Objective: To investigate the changes and clinical significance of biomarker fecal bile acids (BA) in children with Henoch-Schönlein purpura (HSP).

    Methods: Nineteen children with HSP and twenty-seven healthy children were enrolled in this study. The stool samples were obtained at the acute and remission phases. Read More

    Association study between matrix metalloproteinase-9 gene (MMP9) polymorphisms and the risk of Henoch-Schönlein purpura in children.
    Genet Mol Res 2016 Jun 3;15(2). Epub 2016 Jun 3.
    Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
    Henoch-Schönlein purpura nephritis (HSPN), the most serious long-term complication of Henoch-Schönlein purpura, is one of the most common renal diseases in children. Matrix metalloproteinase-9 (MMP-9) is implicated in the pathogenesis of renal diseases. Genomic DNA was isolated from the venous blood leukocytes of 220 unrelated patients with HSPN and 205 unrelated healthy individuals. Read More

    Immunoglobulin A Vasculitis Complicated with Clostridium difficile Infection: a Rare Case Report and Brief Review of the Literature.
    J Gastrointestin Liver Dis 2016 Jun;25(2):235-8
    Gr. T. Popa University of Medicine and Pharmacy;St. Spiridon Emergency Hospital, Institute of Gastroenterology and Hepatology, Iasi, Romania.
    Immunoglobulin A (IgA) vasculitis, formerly called Henoch-Schönlein purpura, is a leukocytoclastic type of vasculitis affecting small vessels with a deposition of immune IgA complexes, clinically characterized by the classic tetrad of nonthrombocytopenic palpable purpura, arthralgia (or arthritis), and gastrointestinal and renal involvement. Although the cause of the disease remains unknown, immune complexes of IgA and unidentified antigens seem to play a central pathogenic role. The diagnosis is easily established in the presence of purpura, but may be challenging in its absence, especially when colicky abdominal pain precedes the cutaneous lesions. Read More

    Koebner's Phenomenon in Childhood Henoch-Schönlein Purpura: A Report of Two Cases.
    Pediatr Dermatol 2016 Jul 10;33(4):e249-51. Epub 2016 Jun 10.
    Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
    Koebner's phenomenon occurs rarely in connection with Henoch-Schönlein purpura (HSP). We report two children with HSP who developed Koebner's phenomenon on the second day after the onset of rash. The first was an 11-year-old girl with rheumatic heart disease who presented with abdominal pain for 1 month and subsequently developed rash and nephritis. Read More

    Fludeoxyglucose positron emission tomography-computed tomography scan showing polyarthritis in a patient with an atypical presentation of Henoch-Schönlein vasculitis without clinical signs of arthritis: a case report.
    J Med Case Rep 2016 Jun 2;10(1):159. Epub 2016 Jun 2.
    Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.
    Background: Henoch-Schönlein vasculitis is the most common systemic vasculitis in children. Arthritis or arthralgia occurs in 80 % of patients. We believe this to be the first case report to describe the finding of polyarthritis in a fludeoxyglucose positron emission tomography-computed tomography scan in a patient with Henoch-Schönlein vasculitis without clinical signs of arthritis. Read More

    Acute Genitourinary Swelling and Erythema as Presenting Symptoms of Henoch-Schonlein Purpura.
    Pediatr Emerg Care 2016 Jun;32(6):384-5
    From the *Summerville Pediatric Emergency Department, Summerville and †Division of Pediatric Emergency Medicine,Medical University of South Carolina, Charleston, SC.
    Henoch-Schonlein purpura (HSP) may present in a variety of ways, most commonly with joint pain or the distinctive palpable purpura. Genitourinary manifestations of HSP are less common and may precede the classic signs and symptoms of HSP, making the diagnosis difficult. We report a case of a 19-month-old boy with penile and scrotal erythema and swelling at presentation who was later diagnosed with HSP. Read More

    HLA-DRB1 in Henoch-Schönlein purpura: A susceptibility study from North India.
    Hum Immunol 2016 Jul 13;77(7):555-8. Epub 2016 May 13.
    Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
    Etiology of Henoch-Schönlein purpura (HSP) a small vessel vasculitis remains elusive. Susceptibility may be conferred by major histocompatibility complex. There are limited reports on the association of human leucocyte antigens (HLA) and HSP. Read More

    HENOCH-SCHONLEIN PURPURA IN CHILDHOOD A FIFTEEN-YEAR EXPERIENCE AT A TERTIARY HOSPITAL.
    J Med Liban 2016 Jan-Mar;64(1):13-7
    Objective: To examine the epidemiological and clinical characteristics of children diagnosed with Henoch Sch6nlein purpura (HSP) and to compare them with other areas in the world.

    Methods: The medical records of children with HSP were retrospectively reviewed at the Jordan University Hospital between the years 1998 and 2012. The clinical and demographical features, laboratory tests, management and outcome were assessed. Read More

    Petechial rash in children: a clinical dilemma.
    Emerg Nurse 2016 May;24(2):27-35; quiz 37
    Torbay Hospital, Torquay.
    Children with a petechial rash commonly present to emergency departments. The rash can be associated with serious illnesses, such as invasive meningococcal disease (IMD), but is usually associated with less severe conditions. This article discusses the common and important causes of petechial rash, including IMD, viral illnesses, trauma, Henoch-Schönlein purpura and idiopathic thrombocytopenic purpura. Read More

    Nephrology Update: Glomerular Disease in Children.
    FP Essent 2016 May;444:30-40; quiz 41-3
    Department of Pediatrics Case Western Reserve University School of Medicine, 11100 Euclid Ave, Cleveland, OH 44106.
    Although kidney disease is much less common in children than in adults, clinicians must remain alert for the renal conditions that occur in this population because prompt diagnosis and management are essential. Acute postinfectious glomerulonephritis occurs as an uncommon sequela of streptococcal and other infections. Management is focused on providing supportive measures, including management of fluid-electrolyte imbalance and hypertension, until the patient recovers. Read More

    Intravenous immunoglobulins for severe gastrointestinal involvement in pediatric Henoch-Schönlein purpura: A French retrospective study.
    Arch Pediatr 2016 Jun 26;23(6):584-90. Epub 2016 Apr 26.
    Pédiatrie générale multidisciplinaire, CHU Estaing, 1, place Lucie-et-Raymond-Aubrac, 63003 Clermont-Ferrand, France; Inserm CIC 1405, 1, place Lucie-et-Raymond-Aubrac, 63003 Clermont-Ferrand, France. Electronic address:
    Objective: Severe gastrointestinal involvement of Henoch-Schönlein purpura (HSP) is rare but potentially life-threatening. Management of severe gastrointestinal involvement in HSP is not codified. Symptomatic care and steroids are a first-line therapy. Read More

    Henoch-Schönlein Purpura in the ED.
    Am J Nurs 2016 May;116(5):57-60
    Margaret Carman is an assistant professor in the Duke University School of Nursing, Durham, NC; she also coordinates Emergency. Jennifer Forsman is a staff nurse in a pediatric cardiology-oncology unit at the University of North Carolina Hospital, Chapel Hill. Contact author: Margaret Carman, The authors have disclosed no potential conflicts of interest, financial or otherwise.
    Diagnosing and treating a child with the most common form of pediatric vasculitis. Read More

    Treatment Outcomes in Children with Henoch-Schönlein Nephritis.
    Adv Exp Med Biol 2016 ;912:65-72
    Department of Pediatrics and Nephrology, Medical University of Warsaw, 63A Żwirki i Wigury St, 02-091, Warsaw, Poland.
    The aim of the present study was to quantify the effects of treatment of children with Henoch-Schönlein nephritis (HSN) evaluated on the basis of kidney biopsy findings. Data were analyzed from 32 patients with HSN (mean age 9.3 ± 3. Read More

    [Protective Effect of Total Flavones of Bidens pilosa L. on IgA1 Induced Injury of HUVECs in Henoch-Schönlein Purpura Children Patients].
    Zhongguo Zhong Xi Yi Jie He Za Zhi 2016 Feb;36(2):183-7
    Objective: To explore the protective effect and mechanism of total flavones of Bidens pilosa L. (TFB) on IgA1 induced injury of venous endothelial cells in Henoch-Schönlein purpura (HSP) children patients. METHODS Human umbilical venous endothelial cells (HUVECs) were taken as subject. Read More

    Henoch-Schönlein purpura complicated by acalculous cholecystitis and intussusception, and following recurrence with appendicitis.
    Paediatr Int Child Health 2016 May 29;36(2):157-9. Epub 2016 Jan 29.
    c Departments of Pediatrics.
    Henoch-Schönlein purpura (HSP) is the most common childhood systemic vasculitis. Gastro-intestinal involvement occurs in two-thirds of patients. The characteristic skin lesions generally precede abdominal symptoms or present concurrently. Read More

    The Optimal Cut-Off Value of Neutrophil-to-Lymphocyte Ratio for Predicting Prognosis in Adult Patients with Henoch-Schönlein Purpura.
    PLoS One 2016 13;11(4):e0153238. Epub 2016 Apr 13.
    Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.
    Background: The development of gastrointestinal (GI) bleeding and end-stage renal disease (ESRD) can be a concern in the management of Henoch-Schönlein purpura (HSP). We aimed to evaluate whether the neutrophil-to-lymphocyte ratio (NLR) is associated with the prognosis of adult patients with HSP.

    Methods: Clinical data including the NLR of adult patients with HSP were retrospectively analyzed. Read More

    Skin Rash and Microscopic Hematuria in a 10-Year-Old Caucasian Male.
    Lab Med 2016 May;47(2):158-62
    Department of Pathology, University of Texas Medical Branch-Galveston, Galveston, Texas
    Objective: Henoch-Schonlein purpura (HSP) is an acute, systemic, vasculitis with IgA-dominant immune deposits. With the emphasis on educational value of HSP, which is the most common form of vasculitis in children, we report an actual case from a 10-year-old boy.

    Method: The patient presented with the chief complaint of a skin rash. Read More

    Autoimmune progesterone dermatitis: Case report with history of urticaria, petechiae and palpable pinpoint purpura triggered by medical abortion.
    S Afr Med J 2016 Mar 17;106(4):48-50. Epub 2016 Mar 17.
    Anatomy and Histopathology, Medical Biosciences Department, University of the Western Cape, Cape Town; Mbeya Referral Hospital, Ministry of Health and Social Welfare, Mbeya, Tanzania.
    Autoimmune progesterone dermatitis (APD) is a rare autoimmune response to raised endogenous progesterone levels that occur during the luteal phase of the menstrual cycle. Cutaneous, mucosal lesions and other systemic manifestations develop cyclically during the luteal phase of the menstrual cycle when progesterone levels are elevated. APD symptoms usually start 3 - 10 days before menstruation and resolve 1 - 2 days after menstruation ceases. Read More

    A Lower Proportion of Regulatory B Cells in Patients with Henoch-Schoenlein Purpura Nephritis.
    PLoS One 2016 31;11(3):e0152368. Epub 2016 Mar 31.
    Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun, China.
    Background: Henoch-Schoenlein purpura is the one of most common types of systemic vasculitis that involves impaired renal function and Henoch-Schoenlein purpura nephritis (HSPN). The diagnosis of this condition is largely based on immunohistologic detection of immunoglobulin A1-containing immune complex in the glomerular deposits of mesangium. Despite clinical advances, the etiopathogenesis of HSPN is still largely unknown. Read More

    Henoch-Schönlein purpura with joint involvement: Analysis of 71 cases.
    Pediatr Rheumatol Online J 2016 Mar 31;14(1):20. Epub 2016 Mar 31.
    Dongying Hospital of Shandong Provincial Hospital, Dongying, Shandong province, 257091, China.
    Background: Although joint involvement is the second most common clinical manifestation after skin involvement in patients with Henoch-Schönlein purpura (HSP), it has not been well characterized. The aim of this study was to profile the clinical characteristics and identify the potential risk factors for kidney damage in HSP patients having joint involvement.

    Methods: We retrospectively reviewed 71 cases of HSP patients with joint involvement who attended our hospital between January 2010 and March 2012 and analyzed their epidemiological profile, clinical characteristics, follow-up findings (up to three years) and overall prognosis. Read More

    Association between IL17A and IL17F polymorphisms and risk of Henoch-Schonlein purpura in Chinese children.
    Rheumatol Int 2016 Jun 28;36(6):829-35. Epub 2016 Mar 28.
    Department of Clinical Laboratory, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, 310003, Zhejiang, People's Republic of China.
    Previous studies suggested that interleukin-17 and Th17 cell play an important role in the pathogenesis of childhood Henoch-Schonlein purpura (HSP). The purpose of our study is to elucidate whether the IL17A and IL17F gene polymorphisms are susceptibility genes for the development of HSP in Chinese children. A total of 148 HSP patients and 202 controls were enrolled for analyzing the single nucleotide polymorphisms (SNP) of IL17A (rs2275913, rs8193037 and rs3819025) and IL17F (rs763780 and rs9463772). Read More

    [Relationship of cystatin C, fibrinogen, and 24-hour urinary protein with renal pathological grade in children with Henoch-Schönlein purpura nephritis].
    Zhongguo Dang Dai Er Ke Za Zhi 2016 Mar;18(3):233-7
    Graduate School, Xinxiang Medical University, Xinxiang, Henan 453003, China.
    Objective: To study the relationship of cystatin C (CysC), fibrinogen (Fbg), and 24-hour urinary protein with renal pathological grade in children with Henoch-Schönlein purpura nephritis (HSPN), and to explore their values.

    Methods: The clinical data of 48 children diagnosed with HSPN by renal biopsy from January 2011 to January 2015 were reviewed. According to renal pathological grading, in the 48 children with HSPN, 12 had stage IIa or lower, 12 stage IIb, 17 stage IIIa, and 7 stage IIIb or higher. Read More

    Successful treatment of recurrent Henoch-Schönlein purpura nephritis in a renal allograft with tonsillectomy and steroid pulse therapy.
    Nephrology (Carlton) 2016 Jul;21 Suppl 1:53-6
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
    We report a case of recurrent Henoch-Schönlein purpura nephritis (HSPN) treated successfully with a tonsillectomy and steroid pulse therapy in a kidney transplant patient. A 29-year-old woman was admitted to our hospital for an episode biopsy; she had a serum creatinine (S-Cr) of 1.0 mg/dL and 1. Read More

    Terminal Ileitis as a Feature of Henoch-Schönlein Purpura Masquerading as Crohn Disease in Adults.
    J Clin Rheumatol 2016 Mar;22(2):82-5
    From the *Department of Pediatrics, Penn State Hershey Children's Hospital; and †Department of Medicine, Penn State Milton S. Hershey Medical Center, Hershey, PA.
    Henoch-Schönlein purpura (HSP), more recently termed immunoglobulin A (IgA) vasculitis, is a systemic small-vessel vasculitis characterized by perivascular IgA deposition. This disease manifests clinically as palpable purpura, arthralgia, gastrointestinal symptoms, and renal dysfunction. Although ileitis can be seen in HSP, terminal ileitis is virtually pathognomonic for Crohn disease. Read More

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