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    Location of skin lesions in Henoch-Schönlein purpura and its association with significant renal involvement.
    J Am Acad Dermatol 2018 Jan;78(1):115-120
    Department of Dermatology, Massachusetts General Hospital, Harvard University, Boston, Massachusetts. Electronic address:
    Background: Henoch-Schönlein purpura (HSP) is a small vessel IgA-predominant vasculitis.

    Objective: To describe adult patients with HSP and determine if the distribution of skin lesions (ie, purpura above the waist or purpura below the waist only), is a predictor of significant renal involvement at the time of the skin biopsy and the months following.

    Methods: A retrospective study on renal function from 72 adult patients with skin-biopsy proven HSP. Read More
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    Biomarkers of IgA vasculitis nephritis in children.
    PLoS One 2017 30;12(11):e0188718. Epub 2017 Nov 30.
    INSERM 1149, Center of Research on Inflammation (CRI), Paris, France.
    Henoch-Schönlein purpura is a systemic vasculitis characterized by IgA deposits, which target the skin, joints, and kidneys, among other organs. In children, prognosis is often good but little is known about biomarkers of pediatric nephritis. We hypothesized that biological markers, including cytokines, immunoglobulins, IgA-immune complexes, IgA glycosylation and neutrophil gelatinase-associated lipocalin (NGAL), may discriminate IgA vasculitis (IgAV) pediatric patients with renal involvement from those without renal involvement. Read More
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    Clinical significance of the serum biomarker index detection in children with Henoch-Schonlein purpura.
    Clin Biochem 2018 Feb 10;52:167-170. Epub 2017 Nov 10.
    School of Medical Laboratory, Tianjin Medical University, No.1 Guangdong Road, Hexi District, Tianjin 300203, China. Electronic address:
    Objective: To explore a panel of serum biomarkers for laboratory diagnosis of pediatric Henoch-Schönlein purpura (HSP).

    Methods: The blood white blood cells (WBC) and serum levels of serum amyloid A (SAA), interleukin 6 (IL-6), immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), immunoglobulin E (IgE), C-reactive protein (CRP), complement component 3 (C3), complement component 4 (C4), and ASO (anti-streptolysin O) were detected in 127 patients with Henoch-Schonlein purpura (HSP), 110 cases of septicemia patients, and 121 healthy volunteers. The diagnostic ability of biomarkers selected from HSP and septicemia patients was analyzed by ROC curve. Read More
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    Kidney Injury Molecule-1 Level is Associated with the Severity of Renal Interstitial Injury and Prognosis in Adult Henoch-Schönlein Purpura Nephritis.
    Arch Med Res 2017 Jul 6;48(5):449-458. Epub 2017 Nov 6.
    Department of Nephrology, Qilu Hospital of Shandong University, Jinan, China. Electronic address:
    Background And Aims: Kidney injury molecule-1 (KIM-1) was identified the most highly upregulated protein in chronic kidney diseases and prolonged KIM-1 expression may be maladaptive. The present study was aimed to investigate urinary, renal and plasma KIM-1 levels and to analyze association between KIM-1 levels with clinical and pathological indexes in adult Henoch-Schönlein purpura (HSP) patients.

    Methods: Twenty healthy individuals, 20 HSP patients without nephritis and 35 HSP patients with nephritis were recruited. Read More
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    New insights in the pathogenesis of immunoglobulin A vasculitis (Henoch-Schönlein purpura).
    Autoimmun Rev 2017 Dec 14;16(12):1246-1253. Epub 2017 Oct 14.
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, De Boelelaan 1109, 1081 HZ Amsterdam, The Netherlands; Amsterdam Infection & Immunity Institute, Amsterdam, The Netherlands; Department of Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. Electronic address:
    Immunoglobulin A vasculitis (IgAV), also referred to as Henoch-Schönlein purpura, is the most common form of childhood vasculitis. The pathogenesis of IgAV is still largely unknown. The disease is characterized by IgA1-immune deposits, complement factors and neutrophil infiltration, which is accompanied with vascular inflammation. Read More
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    The relationship between red cell distribution width and the risk of Henoch-Schönlein purpura nephritis.
    Br J Biomed Sci 2018 Jan 9;75(1):30-35. Epub 2017 Oct 9.
    a Department of Clinical Laboratory , Guangxi Medical University First Affiliated Hospital , Nanning , China.
    Introduction: Red blood cell distribution width (RDW) is elevated in various inflammatory diseases, but its clinical significance in Henoch-Schönlein purpura nephritis (HSPN) in unknown. The aim of this study was to determine the value of RDW as a risk factor or marker for HSPN in children.

    Methods: This was a case-control study of 105 Henoch-Schönlein purpura (HSP) patients, 120 HSPN patients and 192 healthy controls. Read More
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    Encephalopathy in Henoch-Schönlein Purpura.
    Indian Pediatr 2017 Aug;54(8):675-677
    Departments of Nephrology, *Thoracic and Cardiovascular Surgery, and #Neonatology; The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China. Correspondence to: Dr JH Mao, Department of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang Province, China.
    Background: Henoch-Schönlein purpura (HSP) is the most common vasculitis in childhood. Severe central nervous system (CNS) involvement is rare in HSP.

    Case Characteristics: Three children with features of HSP presented with seizures and CNS dysfunction. Read More
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    Cutaneous Manifestations of Small-Vessel Leukocytoclastic Vasculitides in Childhood.
    Clin Rev Allergy Immunol 2017 Dec;53(3):439-451
    Pediatric Department of Southern Switzerland, San Giovanni Hospital, 6500, Bellinzona, Switzerland.
    In childhood, cutaneous small-vessel vasculitides include Henoch-Schönlein syndrome, a systemic vasculitis, and Finkelstein-Seidlmayer syndrome, a skin-limited vasculitis. Both Henoch-Schönlein and Finkelstein-Seidlmayer syndromes are seen more frequently in white or Asian compared with black children and occur especially in winter and spring with a male-to-female ratio of approximately 2:1. In everyday clinical practice, both conditions are diagnosed on clinical grounds without histological confirmation. Read More
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    Henoch-Schonlein purpura associated with primary active Epstein-Barr virus infection: a case report.
    Pan Afr Med J 2017 11;27:29. Epub 2017 May 11.
    University of Health Sciences, Umraniye Research and Training Hospital, Department of Pediatrics, Istanbul, Turkey.
    Henoch-Schönlein purpura (HSP) is the most common form of childhood vasculitis. Various viral and bacterial infections, drugs, vaccines, food allergy and even insect bites have been considered as triggering factors in pathogenesis of HSP. Epstein-Barr virus (EBV) infection, which is associated with HSP, have been rarely reported. Read More
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    "Joining the Spots in Adults and Young Tots": A Clinicopathological Study of Henoch-Schönlein Purpura (IgA Vasculitis).
    Am J Dermatopathol 2017 Aug;39(8):587-592
    Departments of *Pathology, and†Dermatology, St. John's Medical College and Hospital, Bangalore, India. Dr. Divya is now a Consultant Histopathologist, Columbia Asia Referral Hospital, Yeshwantpur, India.
    Introduction: Henoch-Schönlein Purpura (HSP; IgA vasculitis), the most common vasculitis of childhood, has a wide spectrum of clinical manifestations ranging from palpable purpura with abdominal pain and arthritis to the more morbid renal involvement.

    Aims And Objectives: To study and correlate the clinical presentation, laboratory values, skin and renal histopathology and immunofluoroscence findings in HSP.

    Material And Methods: A total of 44 cases of HSP from March 2011 to February 2014 were studied for the above features along with their clinical outcomes. Read More
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    Warfarin-induced toxic epidermal necrolysis in combination therapy of Henoch-Schönlein purpura nephritis: a case report.
    BMC Nephrol 2017 Jul 14;18(1):237. Epub 2017 Jul 14.
    Department of Pediatric Nephrology, Japan Red Cross Nagoya Daini Hospital, 2-9, Myoumi-chou, Shouwaku, Nagoya-shi, Aichi-ken, 466-8650, Japan.
    Background: Toxic epidermal necrolysis (TEN) is a rare life-threatening condition almost exclusively attributed to drugs. The main etiologic factors for TEN are sulphonamides, anticonvulsants, and antibiotics; however, there are no published reports of warfarin causing TEN.

    Case Presentation: We present the case of a 3-year-old patient who developed TEN while receiving treatment for Henoch-Schönlein purpura nephritis (HSPN). Read More
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    [Association of serum vitamin D level with severity and treatment in children with Henoch-Schönlein purpura].
    Zhongguo Dang Dai Er Ke Za Zhi 2017 Jul;19(7):796-799
    Department of Pediatrics, Guizhou Provincial People's Hospital, Guiyang 550002, China.
    Objective: To investigate the association of serum vitamin D [25-(OH)D] level with the severity and treatment in children with Henoch-Schönlein purpura (HSP).

    Methods: A total of 50 children with newly-diagnosed HSP between January and December, 2015 were enrolled as HSP group, and 49 healthy children were enrolled as control group. Fasting serum samples were collected, and ELISA was used to measure serum 25-(OH)D level. Read More
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    Association of ACE, VEGF and CCL2 gene polymorphisms with Henoch-Schönlein purpura and an evaluation of the possible interaction effects of these loci in HSP patients.
    Adv Clin Exp Med 2017 Jul;26(4):661-664
    Liver and Gastrointestinal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
    Background: Henoch-Schönlein purpura (HSP) is a multisystem, small vessel, leucocytoclastic vasculitis. It is predominantly a childhood vasculitis, rarely reported in adults. Studies have shown that several different genetic factors such as genes involved in inflammatory system and renin-angiotensin system (RAS) are important in the pathogenesis of Henoch-Schönlein purpura. Read More
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    Prevalence and Characteristics of Nonblanching, Palpable Skin Lesions With a Linear Pattern in Children With Henoch-Schönlein Syndrome.
    JAMA Dermatol 2017 Nov;153(11):1170-1173
    Pediatric Department of Southern Switzerland, Bellinzona, Switzerland.
    Importance: Linear nonblanching skin lesions are thought to occur very rarely in patients with Henoch-Schönlein syndrome.

    Objective: To examine the prevalence and characteristics of linear nonblanching skin lesions in children with Henoch-Schönlein syndrome.

    Design, Setting, And Participants: A prospective case series was conducted at the ambulatory practice of a hospitalist between January 1, 2010, and December 31, 2015, among 31 consecutive children with Henoch-Schönlein syndrome. Read More
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    A dirty cause of vancomycin-mediated Henoch-Schonlein purpura: oxygen tubing is not a foley.
    BMJ Case Rep 2017 Jun 20;2017. Epub 2017 Jun 20.
    Internal Medicine, Malcom Randall Veterans Affairs Medical Center, Gainesville, Florida, USA.
    A 59-year-old male presented with methicillin-resistant bacteraemia from a prostatic abscess and was treated with vancomycin. Two weeks into his treatment course, he developed severe joint pains, abdominal pain with bloody, mucinous stools and a diffuse palpable purpuric rash on his extremities. Biopsy of the rash showed IgA immune-complex deposition consistent with Henoch-Schönlein purpura. Read More
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    [Henoch-Schönlein Purpura Presenting as Intussusception].
    Korean J Gastroenterol 2017 Jun;69(6):372-376
    Department of Surgery, Wonkwang University School of Medicine, Iksan, Korea.
    Henoch-Schönlein purpura (HSP) is systemic vasculitis disease with various clinical manifestations. Gastrointestinal symptoms in patients with HSP are usually common, with an incidence rate of 62-90%. Most of these gastrointestinal symptoms occur after typical skin purpura, which is a very important clinical evidence for making a diagnosis of HSP. Read More
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    Characteristics and Management of IgA Vasculitis (Henoch-Schönlein) in Adults: Data From 260 Patients Included in a French Multicenter Retrospective Survey.
    Arthritis Rheumatol 2017 09;69(9):1862-1870
    Department of Nephrology, Hôpital Saint Louis, AP-HP, Université Paris Descartes, Paris, France.
    Objective: Data on adult IgA vasculitis (Henoch-Schönlein) (IgAV) are scarce. This survey was designed to better define the clinical spectrum of IgAV and efficacy of treatments in a French patient population.

    Methods: Data on clinical characteristics, histologic features, and treatment response from 260 patients with IgAV included in a French multicenter retrospective survey were analyzed. Read More
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    Inducible nitric oxide synthase gene polymorphisms are associated with a risk of nephritis in Henoch-Schönlein purpura children.
    Eur J Pediatr 2017 Aug 8;176(8):1035-1045. Epub 2017 Jun 8.
    Department of Ultrasound, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xincheng District, Xi'an, Shaanxi, 710004, People's Republic of China.
    Henoch-Schönlein purpura (HSP) is the most common form of systemic small-vessel vasculitis in children, and HSP nephritis (HSPN) is a major complication of HSP and is the primary cause of morbidity and mortality. Previous studies have suggested that inducible nitric oxide synthase (iNOS) may play an important role in the pathogenesis of HSP. In this study, we performed a detailed analysis to investigate the potential association between iNOS polymorphisms and the risk of HSP and the tendency for children with HSP to develop HSPN in a Chinese Han population. Read More
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    Association between red blood cell distribution width and Henoch-Schonlein purpura nephritis.
    Medicine (Baltimore) 2017 Jun;96(23):e7091
    aDepartment of Clinical Laboratory bDepartment of Nephrology, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
    To investigate whether red blood cell distribution width (RDW) is a marker of the risk of Henoch-Schonlein purpura (HSP) nephritis (HSPN), a total of 669 HSP patients and 168 healthy controls were included in this retrospective study. Two hundred fifty-six (38.3%) of the patients had kidney involvement. Read More
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    Clinical characteristics of intussusception secondary to pathologic lead points in children: a single-center experience with 65 cases.
    Pediatr Surg Int 2017 Jul 5;33(7):793-797. Epub 2017 Jun 5.
    Department of Pediatric Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
    Objective: Intussusception secondary to pathologic lead points (PLPs) is a challenging condition for pediatric surgeons, and few studies have been published on this subject. The aim of this study was to review and analyze clinical data on the diagnosis and management of intussusception secondary to PLPs in children.

    Methods: Between 2002 and 2016, a total of 65 pediatric patients with a diagnosis of intussusception secondary to PLPs were retrospectively reviewed. Read More
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    [Cutaneous leukocytoclastic vasculitis: about 85 cases].
    Pan Afr Med J 2017 14;26:138. Epub 2017 Mar 14.
    Université du Centre, Tunisie.
    Clinical manifestation, etiology and outcome of leukocytoclastic vasculitis are little studied. The aim of our study was to examine epidemiological, clinical etiological, and evolutionary characteristics of this entity. We conducted a cross-sectional data collection from medical records of 85 patients with leukocytoclastic vasculitis in the Department of Dermatology at the Farhat Hached University Hospital, Sousse between January 2000 and December 2013. Read More
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    Evaluation of Mycophenolate Mofetil and Low-Dose Steroid Combined Therapy in Moderately Severe Henoch-Schönlein Purpura Nephritis.
    Med Sci Monit 2017 May 18;23:2333-2339. Epub 2017 May 18.
    Department of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (mainland).
    BACKGROUND The most appropriate management of Henoch-Schönlein Purpura (HSP) nephritis with nephrotic-range proteinuria remains uncertain. The aim of this study was to evaluate the clinical therapeutic effects of mycophenolate mofetil and low-dose steroid in Henoch-Schönlein purpura nephritis (HSPN) with nephrotic-range proteinuria and pathological classification less than IV in children. MATERIAL AND METHODS The clinical effects of MMF and low-dose steroid therapy were studied in children with Henoch-Schönlein purpura nephritis manifested with nephrotic-range proteinuria, normal kidney function, and <50% crescents or sclerosing lesions on renal biopsy. Read More
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    Incidence of IgA vasculitis in children estimated by four-source capture-recapture analysis: a population-based study.
    Rheumatology (Oxford) 2017 Aug;56(8):1358-1366
    ECSTRA, Université Paris 7-Diderot.
    Objectives: The aim was to describe the epidemiological characteristics of childhood IgA vasculitis (IgAV) defined by the EULAR/PRINTO/Paediatric Rheumatology European Society criteria in a population-based sample from France and ascertain its incidence over 3 years by a four-source capture-recapture analysis.

    Methods: Cases were prospectively collected in Val de Marne county, a suburb of Paris, with 263 874 residents <15 years old. Children with incident IgAV living in this area from 2012 to 2014 were identified by four sources of case notification (emergency departments, paediatrics departments, private-practice paediatricians and general practitioners). Read More
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    Expression of Acid-Sensing Ion Channels in Renal Tubular Epithelial Cells and Their Role in Patients with Henoch-Schönlein Purpura Nephritis.
    Med Sci Monit 2017 Apr 21;23:1916-1922. Epub 2017 Apr 21.
    Department of Pediatrics, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China (mainland).
    BACKGROUND Acid-sensing ion channels (ASICs) are ligand-gated cation channels activated by extracellular protons. However, the role of ASICs in kidney diseases remains uncertain. This study investigated ASICs expression in kidney tissues and their role in the development of Henoch-Schönlein purpura nephritis (HSPN). Read More
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    Association of Endothelial Nitric Oxide Synthase Gene Polymorphism with Susceptibility and Nephritis Development of Henoch-Schönlein Purpura in Chinese Han Children.
    Genet Test Mol Biomarkers 2017 Jun 14;21(6):373-381. Epub 2017 Apr 14.
    3 Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, P.R. China .
    Objective: Henoch-Schönlein purpura (HSP) is the most common form of systemic small-vessel vasculitis in children. Previous studies suggested endothelial nitric oxide synthase (eNOS) plays an important role in the pathogenesis and clinical manifestations of HSP. This study aimed to investigate the potential association between 10 single-nucleotide polymorphisms (SNPs) within the eNOS gene and HSP risk and nephritis development in a Chinese Han population. Read More
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    [Association between platelet-activating factor acetylhydrolase gene polymorphisms and gastrointestinal bleeding in children with Henoch-Schönlein purpura].
    Zhongguo Dang Dai Er Ke Za Zhi 2017 Apr;19(4):385-388
    Department of Gastroenterology, Wuhan Children's Hospital, Wuhan 430016, China
    Objective: To study the association between the single nucleotide polymorphisms (SNPs) of the ninth exon Val279Phe of platelet-activating factor acetylhydrolase (PAF-AH) gene and gastrointestinal bleeding in children with Henoch-Schönlein purpura (HSP).

    Methods: A total 516 children with HSP were enrolled, among whom 182 had gastrointestinal bleeding and 334 had no gastrointestinal bleeding. PCR was used to investigate the distribution of genotypes and alleles in the SNPs of Val97Phe. Read More
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    Ambulatory arterial stiffness index, blood pressure variability, and nocturnal blood pressure dip in children with IgA and Henoch-Schönlein nephropathy
.
    Clin Nephrol 2017 Jun;87(6):301-309
    Aim: Evaluation of mean blood pressure values, ambulatory arterial stiffness index (AASI), pulse pressure (PP), blood pressure variability (BPV), and circadian blood pressure rhythm using ambulatory blood pressure monitoring (ABPM) in children with IgA nephropathy and Henoch-Schönlein nephropathy (IgAN/HSN).

    Material And Methods: In 48 children (29 with IgAN, 19 with HSN) aged 14.04 ± 3. Read More
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    [Association between CTLA-4 gene polymorphism and Henoch-Schönlein purpura in children].
    Zhongguo Dang Dai Er Ke Za Zhi 2017 Mar;19(3):296-302
    Department of Pediatrics, Xi'an Central Hospital, Xi'an 710003, China.
    Objective: To investigate the association between CTLA-4 gene polymorphism and Henoch-Schönlein purpura (HSP) in children.

    Methods: Sixty children who were diagnosed with HSP were enrolled as the case group, consisting of 33 males and 27 females. Thirty healthy children were enrolled as the control group. Read More
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    [Changes in 25-hydroxyvitamin D3 level in children with Henoch-Schönlein purpura].
    Zhongguo Dang Dai Er Ke Za Zhi 2017 Mar;19(3):292-295
    Department of Pediatrics, Baoding Children's Hospital, Baoding, Hebei 071000, China.
    Objective: To examine the changes in 25-hydroxyvitamin D [25-(OH)D] level in children with Henoch-Schönlein purpura (HSP) and its clinical significance.

    Methods: A total of 92 HSP children were included in this study, and were divided into HSP nephritis (HSPN) group (31 cases) and HSP group (61 cases) based on the presence or absence of HSPN. Alternatively, the patients were divided into purpura alone group (22 cases), purpura with joint symptoms group (joint symptom group, 24 cases), purpura with gastrointestinal symptoms group (gastrointestinal symptom group, 20 cases), and purpura with joint and gastrointestinal symptoms (mixed group, 26 cases) based on their clinical symptoms. Read More
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    Evaluation of TGF-β1 and MCP-1 expression and tubulointerstitial fibrosis in children with Henoch-Schönlein purpura nephritis and IgA nephropathy: A clinical correlation.
    Clinics (Sao Paulo) 2017 Feb 1;72(2):95-102. Epub 2017 Feb 1.
    The Children's Hospital of Zhejiang University School of Medicine, Department of Nephrology, Hangzhou 310003, Zhejiang Province, China.
    Objectives:: Henoch-Schönlein purpura nephritis and immunoglobulin A nephropathy are two diseases with similar clinical presentations but very different prognoses. Transforming growth factor β1 and monocyte chemoattractant protein-1 have been associated with the development of tissue fibrosis. We examined the development of tubulointerstitial fibrosis and its relationship with Transforming growth factor β1 and monocyte chemoattractant protein-1 expression in these patients. Read More
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    A single-center analysis of Henoch-Schonlein purpura nephritis with nephrotic proteinuria in children.
    Pediatr Rheumatol Online J 2017 Mar 4;15(1):15. Epub 2017 Mar 4.
    Department of Nephrology and Rheumatology, Shanghai Children's Hospital, Shanghai Jiao Tong University, 355 Luding Road, Shanghai, 200062, People's Republic of China.
    Background: In children with Henoch-Schonlein purpura nephritis (HSPN), the degree of proteinuria has been proven to be not only a sign of kidney damage, but also an accelerator of kidney disease progression. Nephrotic proteinuria at disease onset has been proposed as a predictor of a poor renal outcome. This study aims to assess the clinical and pathological features of HSPN with nephrotic proteinuria in a single center. Read More
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    Henoch Schönlein Purpura Nephritis Associated with Intravesical Bacillus Calmette-Guerin (BCG) Therapy.
    Intern Med 2017 1;56(5):541-544. Epub 2017 Mar 1.
    Department of Nephrology, Showa General Hospital, Japan.
    Henoch Schönlein purpura (HSP), also known as IgA vasculitis (IgAV), is a systemic small-vessel vasculitis that predominantly affects adolescents and is rare in adults. In many cases, the onset of HSP has been causally linked to an infectious disease. We encountered a case of HSP with severe renal involvement diagnosed by renal biopsy following bacillus Calmette-Guerin (BCG) therapy for bladder cancer. Read More
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    [Comparison of age-based clinical and abnormal immune parameters in patients with Henoch-Schönlein purpura].
    Zhonghua Xue Ye Xue Za Zhi 2017 Jan;38(1):60-64
    Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.
    To explore age-based clinical and immune parameters in Henoch-Schönlein purpura (HSP) to determine clinically useful markers reflecting disease characteristic. A cohort of 502 patients with HSP were enrolled into this retrospective study to evaluate their clinical and immune data. Majority HSP cases occurred at age ≤14 years and showed significant immune imbalances of ESR, CD3(+) cells, CD4(+) cells, CD3(-)CD16(+)CD56(+) cells, CD4(+)/CD8(+) cells, IgG, IgA, IgM, IgE, complements C3/C4 and ASO in the acute phase. Read More
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    [Retrospective analysis on 337 cases of 
Henoch-Schönlein purpura].
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 2017 Jan;42(1):72-77
    Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
    Objective: To determine differences in incidence, causes, clinical manifestation,prognosis between children and adults in patients with Henoch-Schönlein purpura (HSP).
 Methods: We retrospectively analyzed clinical data of 337 patients who hospitalized in the Department of Dermatology, Peace Hospital affiliated to Changzhi Medical College from Feb. 2013 to Jan. Read More
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    Clinical outcomes in children with Henoch-Schönlein purpura nephritis without crescents.
    Pediatr Nephrol 2017 Jul 15;32(7):1193-1199. Epub 2017 Feb 15.
    Pediatric Nephrology, Armand Trousseau Hospital, APHP, 26 Avenue du Docteur Netter, Paris, 75012, France.
    Background: Henoch-Schönlein purpura is the most common vasculitis in children. Its long-term prognosis depends on renal involvement. The management of Henoch-Schönlein purpura nephritis (HSPN) remains controversial. Read More
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    The ISKDC classification and a new semiquantitative classification for predicting outcomes of Henoch-Schönlein purpura nephritis.
    Pediatr Nephrol 2017 Jul 14;32(7):1201-1209. Epub 2017 Feb 14.
    Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland.
    Background: Histological findings from primary kidney biopsies were correlated with patient outcomes in a national cohort of paediatric Henoch-Schönlein nephritis (HSN) patients.

    Methods: Primary kidney biopsies from 53 HSN patients were re-evaluated using the ISKDC (International Study of Kidney Disease in Children) classification and a modified semiquantitative classification (SQC) that scores renal findings and also takes into account activity, chronicity and tubulointerstitial indices. The ISKDC and SQC classifications were evaluated comparatively in four outcome groups: no signs of renal disease (outcome A, n = 27), minor urinary abnormalities (outcome B, n = 18), active renal disease (outcome C, n = 3) and renal insufficiency, end-stage renal disease or succumbed due to HSN (outcome D, n = 5). Read More
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    A Case of Henoch-Schonlein Purpura Associated with Rotavirus Infection in an Elderly Asian Male and Review of the Literature.
    Am J Case Rep 2017 Feb 8;18:136-142. Epub 2017 Feb 8.
    Department of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
    BACKGROUND Henoch-Schönlein purpura (HSP), a small vessel vasculitis mediated by deposition of immune-complexes containing IgA in the skin, gut, and glomeruli, often presents with abdominal pain, purpuric rash in the lower extremities and buttocks, joint pain, and hematuria. The disease most commonly targets children but can affect adults who tend to have a worse prognosis. CASE REPORT We discuss a case of HSP in an elderly Chinese male who presented with severe proximal bowel inflammation, vasculitic rash, and proteinuria; he was found to have positive stool rotavirus and giardia. Read More
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    Correlation Between Clinicaland Pathological Characteristics of Henoch-Schönlein Purpura Nephritis in Adults.
    Iran J Kidney Dis 2016 Jan;11(1):12-17
    Department of Nephrology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
    Introduction: Henoch-Schönlein purpura nephritis (HSPN) mainly affects children and is less common in adults, but its associated pathological changes are severe in adults, in whom it results in a poor prognosis. This study aimed to analyze the clinical and pathological characteristics of HSPN in adults and to identify the correlations among them.

    Materials And Methods: Clinical and pathological data from139 patients older than 18 years of age who had been diagnosed with HSPN and had received renal biopsy at our center from January 2012 to November 2014 were collected and were grouped according to the different conditions and analyzed retrospectively. Read More
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    Multicentric Castleman's disease associated with IgA vasculitis (Henoch-Schönlein purpura) responding well to tocilizumab: a case report.
    Clin Rheumatol 2017 Mar 6;36(3):729-733. Epub 2017 Feb 6.
    Nephrology Center, Toranomon Hospital, 2-2-2, Toranomon, Minato, Tokyo, 105-8470, Japan.
    A 41-year-old man was referred to our hospital for the evaluation of hypergammaglobulinemia (IgG 2898 mg/dL and IgA 587 mg/dL), inflammation (CRP 6.7 mg/dL and serum interleukin-6 (IL-6) 15.1 ng/L), and anemia (Hb 10. Read More
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    Independent Association between Hyperuricemia and Histopathological Parameters in Chinese Patients with Henöch-Schönlein Purpura Nephritis.
    Clin Lab 2016 Nov;62(11):2271-2275
    Background: This study aimed to investigate the role of hyperuricemia in the development of histopathological changes in HSPN.

    Methods: Clinical and laboratory data pertaining to 139 adult HSPN patients with and without elevated serum uric acid levels were retrospectively evaluated. There was a 14. Read More
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    Blistering eruptions in childhood Henoch-Schönlein syndrome: systematic review of the literature.
    Eur J Pediatr 2017 Apr 4;176(4):487-492. Epub 2017 Feb 4.
    Pediatric unit, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
    The occurrence of blistering eruptions in childhood Henoch-Schönlein syndrome has been so far addressed exclusively in individual case reports. To describe epidemiology, clinical presentation, and therapeutic options in Henoch-Schönlein patients ≤18 years of age with blistering eruptions, we completed a systematic literature search. For the final analysis, we retained 39 reports. Read More
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    Posterior reversible encephalopathy syndrome as a complication of Henoch-Schönlein purpura in a seven-year-old girl.
    Scott Med J 2017 Feb 2;62(1):34-37. Epub 2017 Feb 2.
    3 Community Regional College of Chapecó, Brazil.
    Introduction Henoch-Schönlein purpura is a multisystem small vessel vasculitis. Neurologic manifestations are uncommon. Posterior reversible encephalopathy syndrome is a rare complication of Henoch-Schönlein purpura with typical clinical and neuroimaging findings that occurs most commonly in the setting of severe hypertension and renal injury. Read More
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