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Harefuah 2021 Jun;160(6):349-354

Pediatric Dermatology Unit, Schneider Children's Medical Center of Israel.

Background: Traditionally, most children diagnosed with Henoch-Schonlein Purpura (HSP) were hospitalized. This policy gradually changed towards selective hospitalization, yet there are still no criteria for admitting pediatric patients with HSP.

Objectives: To examine the clinical features and criteria for hospitalization of pediatric patients with HSP. Read More

Genes Genomics 2021 Jun 19. Epub 2021 Jun 19.

Department of Pediatrics, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon-Si, Gyeonggi-do, Republic of Korea.

Background: Immunoglobulin A nephropathy (IgAN) is one of the most common primary forms of glomerulonephritis, while IgA vasculitis (IgAV) is the most common systemic vasculitis in children.

Objective: Herein we aimed to uncover single nucleotide polymorphism (SNP) markers associated with these two related diseases by applying association tests and Sanger sequencing.

Methods: Within the discovery stage, genomic DNA in blood samples from 101 enrolled patients were genotyped by the Korean Biobank Array. Read More

BMJ Case Rep 2021 Jun 2;14(6). Epub 2021 Jun 2.

Department of Nephrology, Tokyo Metropolitan Geriatric Hospital, Itabashi-ku, Japan.

The diagnosis of elderly-onset IgA vasculitis (IgAV) and its prognosis can be difficult to ascertain because of its rarity and the frequent presence of comorbidities. Furthermore, the treatment of elderly-onset IgAV remains controversial. We report a case of IgAV in an 87-year-old patient. Read More

Pol Merkur Lekarski 2021 Apr;49(290):99-102

Department of Internal Disease, Nephrology and Dialysotherapy, Military Institute of Medicine, Warsaw, Poland.

Henoch-Schönlein-purpura (HSP) is a type of systemic vasculitis characterized by increased serum levels of IgA and the deposition of immune complexes mainly composed of IgA1. The cause of this disease has not yet been known. HSP mainly affects the pediatric population. Read More

Zhongguo Dang Dai Er Ke Za Zhi 2021 Apr;23(4):338-342

Department of Nephrology, Children's Hospital Affiliated to Capital Institute of Pediatrics, Beijing 100020, China.

Objective: To study the efficacy and safety of mycophenolate mofetil (MMF) versus cyclophosphamide (CTX) in the treatment of children with Henoch-Schönlein purpura nephritis (HSPN) and nephrotic-range proteinuria.

Methods: A prospective clinical trial was conducted in 68 pediatric patients who were admitted to the Department of Nephrology, Children's Hospital Affiliated to Capital Institute of Pediatrics and who were diagnosed with HSPN and nephrotic-range proteinuria from August 2016 to November 2019. The patients were randomly divided into two groups:MMF treatment (=33) and CTX treatment (=35). Read More

J Coll Physicians Surg Pak 2021 Mar;31(3):350-352

Department of General Surgery, Abant Izzet Baysal University Hospital, Bolu, Turkey.

Henoch-Schönlein Purpura (HSP) is an autoimmune, systemic, non-granulomatous vasculitis characterised by self-limiting clinical course, and leukocytoclastic vasculitis of small vessels. Deposition of immune complexes that contain IgA is the hallmark of vascular involvement. Adults with HSP have a higher incidence of complications and death. Read More

Clin Exp Rheumatol 2021 Mar-Apr;39 Suppl 129(2):191-192. Epub 2021 Mar 24.

High-Intensity Care Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

BMJ 2021 03 4;372:n329. Epub 2021 Mar 4.

Kidney Disease Center, The First Affiliated Hospital, Zhejiang University, Hangzhou, China

Zhongguo Dang Dai Er Ke Za Zhi 2021 Feb;23(2):111-115

Department of Pediatric Infection and Gastroenterology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.

Objective: To explore the reasonable and effective enteral nutrition regimen for children with abdominal Henoch-Schönlein purpura (HSP).

Methods: A retrospective analysis was performed on the medical data of children with abdominal HSP who were hospitalized from August 2013 to August 2018. According to the starting time of enteral nutrition after abdominal pain relief, the children were divided into three groups: < 24 hours (=68), 24-48 hours (=64), and 48-72 hours (=60). Read More

BMJ Case Rep 2021 Feb 23;14(2). Epub 2021 Feb 23.

Laniado Hospital, Sanz Medical Centre, Netanya, Israel.

A young healthy gardener became febrile with abdominal pain, nausea, vomiting and diarrhoea followed by palpable purpura, mostly on the legs and buttocks with associated arthralgia. Dehydration, azotemia and hyponatraemia resolved with fluid replacement. Tests demonstrated acute pancreatitis, hepatitis, thrombocytopenia, microscopic haematuria and proteinuria. Read More

Indian J Pediatr 2021 05 16;88(5):507-508. Epub 2021 Feb 16.

Department of Pediatrics, Bharati Vidyapeeth University Medical College Hospital & Research Centre, Pune, Maharashtra, 411043, India.

Int Immunopharmacol 2021 May 12;94:107454. Epub 2021 Feb 12.

Sichuan Provincial Center for Gynecology and Breast Diseases, Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, PR China. Electronic address:

Objective: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are associated with the severity of Henoch-Schonlein purpura (HSP). Therefore, we conducted a meta-analysis to evaluate the clinical significance of NLR and PLR in HSP and its complications.

Methods: A comprehensive literature search was conducted by searching the PubMed, EMBASE, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Wanfang, VIP, and SinoMed databases from their inception to September 31, 2020. Read More

BMJ Case Rep 2021 Jan 25;14(1). Epub 2021 Jan 25.

Department of Pediatrics, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA.

An infant presented to the emergency department with sudden onset of rapidly progressing erythematous macules and distal oedema. The rash was striking in appearance, covering most of the body, which raised concern for pressing infectious (eg, meningococcaemia) and other serious aetiologies. Nevertheless, the infant remained playful and was overall stable and posed a diagnostic and management dilemma. Read More

Zhongguo Dang Dai Er Ke Za Zhi 2021 Jan;23(1):49-54

Department of Pediatrics, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, China.

Objective: To study the clinical effect and mechanism of total glucosides of paeony (TGP) in the adjuvant therapy for children with Henoch-Schönlein purpura nephritis (HSPN).

Methods: Sixty-four HSPN children with moderate proteinuria were divided into a TGP treatment group (=34) and a routine treatment group (=30) using a random number table. Thirty healthy children who underwent physical examination were enrolled as the healthy control group. Read More

Pediatr Ann 2021 Jan;50(1):e44-e48

We describe the case of a child with progressive abdominal pain and rash admitted to a large tertiary children's hospital in the Chicago metropolitan area and subsequently found to have immunoglobulin A (IgA) vasculitis and coronavirus disease 2019 (COVID-19). This patient presented with abdominal pain, purpuric lesions, hematochezia, increasingly elevated D-dimer, and abnormal inflammatory markers on laboratory evaluation. To the best of our knowledge, this article describes the only reported pediatric case of COVID-19 associated with IgA vasculitis. Read More

Medicine (Baltimore) 2021 Jan;100(1):e24093

Department of Woman, Child and General and Specialized Surgery.

Rationale: Henoch-Schönlein Purpura (HSP) is an acute small vessel vasculitis. It is the most common vasculitis in children. In majority of the cases, the disease is self-limited. Read More

BMJ Case Rep 2021 Jan 6;14(1). Epub 2021 Jan 6.

Pediatrics, Bahrain Defence Force Royal Medical Services, Riffa, Bahrain.

Henoch-Schonlein purpura (HSP) is a common IgA-mediated small vessel vasculitis of childhood that affects several systems. It is characterised by a tetrad of dermatological, abdominal, joint and renal manifestations. HSP can occur secondary to upper respiratory tract infections, medications, vaccinations and malignancies. Read More

Int J Mol Sci 2020 Dec 23;22(1). Epub 2020 Dec 23.

Division of Nephrology, Department of Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.

Over the past decades, substantial work has established that hemoglobin oxidation and heme release play a pivotal role in hemolytic/hemorrhagic disorders. Recent reports have shown that oxidized hemoglobins, globin-derived peptides, and heme trigger diverse biological responses, such as toll-like receptor 4 activation with inflammatory response, reprogramming of cellular metabolism, differentiation, stress, and even death. Here, we discuss these cellular responses with particular focus on their mechanisms that are linked to the pathological consequences of hemorrhage and hemolysis. Read More

J Paediatr Child Health 2020 12;56(12):1993

Department of Pediatric Infectious Diseases, Dr. Sami Ulus Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.

J Pediatr 2021 04 13;231:289-290. Epub 2020 Dec 13.

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.

Int J Clin Pract 2021 Apr 9;75(4):e13930. Epub 2021 Jan 9.

Department of Pediatrics, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Background: Immunoglobulin A (IgA) vasculitis is the most common vasculitides of childhood. The aim of this study was to characterise the disease and identify clinical and laboratory factors associated with renal involvement.

Methods: Medical records of children aged ≤18 years with the diagnosis of IgA vasculitis according to the EULAR/PRES criteria were retrospectively reviewed for demographic data, clinical manifestations and laboratory tests. Read More

Medicine (Baltimore) 2020 Dec;99(49):e23492

Department of Nephrology.

Rationale: Understanding the association between Henoch-Schönlein purpura (HSP) and malignancy is essential for early diagnosis and treatment of the potential lethal disease. To the best of our knowledge, there has been only one published case of HSP coexisting with oesophageal cancer. Here, we report another patient diagnosed with HSP and oesophageal squamous carcinoma simultaneously. Read More

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2020 Dec;28(6):2051-2055

Department of Hematology, The First Affiliated Hospital of Anhui Medical University，Hefei 230022, Anhui Province, China,E-mail:

Objective: To investigate the effect of IL-27 on Th17 cells in patients with henoch-schönlein purpura（HSP） in order to further elucidate the pathogenesis.

Methods: Fifty patients with HSP treated in our hospital from April 2019 to July 2019 were selected as HSP group, and 30 volunteers underwent physical examination at the same time were selected as control group. The proportion of Th17 cells in peripheral blood of HSP group and healthy control group was determined by flow cytometry (FCM). Read More

Dermatol Ther 2021 01 3;34(1):e14591. Epub 2020 Dec 3.

First Department of Internal Medicine, Laiko General Hospital, Medical School of National & Kapodistrian University of Athens, Athens, Greece.

Pediatr Infect Dis J 2021 02;40(2):e93-e94

From the Department of Pediatrics.

The coronavirus disease 2019 global pandemic is reshaping our understanding of medicine, including the diagnostic approach to common medical presentations. We describe a novel case of a 3-year-old male with a clinical diagnosis of Henoch-Schonlein Purpura vasculitis with concurrent SARS-CoV-2 infection. This case highlights a potentially newly described presentation of coronavirus disease 2019 infection. Read More

Autoimmun Rev 2021 Jan 14;20(1):102707. Epub 2020 Nov 14.

Regional Center of Pharmacovigilance, Department of Pharmacology, Cochin Hospital, AP-HP Centre - Université de Paris, Paris, France. Electronic address:

Objectives: IgA vasculitis (IgAV) is an immune complex small-vessel vasculitis. Drug-induced IgAV cases were rarely reported in the literature. Drug causality assessment is challenging as many other etiological factors can be involved. Read More

Clin Rheumatol 2021 Apr 5;40(4):1659-1660. Epub 2020 Nov 5.

Department of Dermatology & Cosmetology, MEDENS Hospital, Panchkula, Haryana, 134113, India.

BMJ Case Rep 2020 Nov 2;13(11). Epub 2020 Nov 2.

Department of Human Pathology in Adult and Developmental Age 'Gaetano Barresi', University of Messina, Messina, Sicilia, Italy

Acute haemorrhagic oedema of infancy (AHOI) is a rare condition and an unusual diagnosis for the paediatrician, as approximately 300 cases have been reported in literature so far. Although it was considered for years a less serious variant of Henoch-Schönlein purpura, nowadays it is thought to be a different entity, with his own characteristics and clinical outcome. In literature it is described as a benign condition, self-limiting and without any systemic involvement in most of the cases. Read More

Ann Rheum Dis 2021 02 2;80(2):140-142. Epub 2020 Nov 2.

Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany.

BMC Pediatr 2020 11 2;20(1):501. Epub 2020 Nov 2.

Department of Nephrology and Immunology, Children's Hospital of Soochow University, 303 Jingde Road, Suzhou, 215003, Jiangsu, China.

Background: The long-term prognosis of Henoch-Schönlein purpura (HSP) depends on the severity of renal involvement, and crescent formation is considered an important risk factor for poor prognosis of Henoch-Schönlein purpura nephritis (HSPN). The objective of this study was to evaluate factors affecting crescent formation in children with HSPN.

Methods: Demographic factors, clinical characteristics, and laboratory data of children with HSPN with or without crescents were retrospectively analyzed. Read More