4,386 results match your criteria Henoch-Schonlein Purpura Anaphylactoid Purpura


[Effect of miR-21 on the expression of interleukin-10 in B cell of patients with Henoch-Schonlein purpura].

Zhonghua Er Ke Za Zhi 2018 Dec;56(12):939-944

Rheumatology & Immunology Department of Shenzhen Children's Hospital, Shenzhen 518038, China.

To investigate the effect of microRNAs (miR)-21 on the expression of interleukin (IL)-10 in B cell of patients with Henoch-Schonlein purpura (HSP). From March 2016 to January 2017, twenty-four children with HSP hospitalized in rheumatology and immunology department of Shenzhen Children's Hospital were enrolled into the study, including 12 males and 12 females. Patients were divided into purpura nephritis group (HSPN, 14 cases) and non-nephritis group (NHSPN, 10 cases). Read More

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December 2018
2 Reads

Cord-derived mesenchymal stem cells therapy for liver cirrhosis in children with refractory Henoch-Schonlein purpura: A case report.

Medicine (Baltimore) 2018 Nov;97(47):e13287

Department of Pediatrics, Shandong Provincial Qianfoshan Hospital of Shandong University, Jinan, China.

Rationale: To explore the curative effect of human umbilical cord-derived mesenchymal stem cell (ucMSC) therapy for patients with liver cirrhosis complicated with immune thrombocytopenia and refractory Henoch-Schonlein purpura (HSP).

Patient Concerns: A 12-year-old boy presented to our hospital with an 11-month history of purpura on the skin of both lower limbs accompanied by thrombocytopenia. The patient had a history of repeated swelling and painful dorsum pedis, followed by skin redness. Read More

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http://dx.doi.org/10.1097/MD.0000000000013287DOI Listing
November 2018
7 Reads

Immunoglobulin A Nephropathy and Immunoglobulin A Vasculitis.

Pediatr Clin North Am 2019 Feb;66(1):101-110

Department of Pediatrics, Medical University of South Carolina, 96 Jonathan Lucas Street, 428 CSB, MSC 608, Charleston, SC 29425, USA. Electronic address:

Henoch-Schönlein purpura nephritis and immunoglobulin A nephropathy are common glomerulopathies in the pediatric population that deserve special attention. In some cases the primary care provider can follow the patient but others need more intensive management. Delaying this treatment can lead to worse morbidity. Read More

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http://dx.doi.org/10.1016/j.pcl.2018.08.008DOI Listing
February 2019
1 Read

Rituximab treatment for chronic steroid-dependent Henoch-Schonlein purpura: 8 cases and a review of the literature.

Pediatr Rheumatol Online J 2018 Nov 14;16(1):71. Epub 2018 Nov 14.

Department of Pediatrics, Division of Rheumatology, University of Alabama at Birmingham, 1600 7th Ave S, CPPN G10, Birmingham, AL, 35233, USA.

Background: Henoch-Schonlein purpura (HSP) is a small vessel vasculitis that is characterized by non-thrombocytopenic purpura, abdominal pain, arthritis, and glomerulonephritis. Typically, HSP is self-limited requiring only supportive care, but more severe cases may require corticosteroid (CS) treatment. Rarely, a subset of these patients has persistent rash, arthritis, abdominal involvement, or renal disease despite treatment with CS, or has disease recurrence on CS tapering. Read More

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https://ped-rheum.biomedcentral.com/articles/10.1186/s12969-
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http://dx.doi.org/10.1186/s12969-018-0285-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236882PMC
November 2018
10 Reads

Effect of Montmorillonite powder on intestinal mucosal barrier in children with abdominal Henoch-Schonlein purpura: A randomized controlled study.

Medicine (Baltimore) 2018 Sep;97(39):e12577

Open Laboratory, West China Institute for Women's and Children's Health, Chengdu, Sichuan Province, China.

Background: Our previous studies found that intestinal barrier function has been changed in children with abdominal Henoch-Schonlein purpura (HSP). Montmorillonite has been shown to be protective for digestive tract mucosa.

Objective: The present study aimed to investigate whether Montmorillonite powder could improve the intestinal mucosal barrier function in children with abdominal HSP. Read More

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http://Insights.ovid.com/crossref?an=00005792-201809280-0008
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http://dx.doi.org/10.1097/MD.0000000000012577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181592PMC
September 2018
6 Reads

Risk factors for renal involvement and severe kidney disease in 2731 Chinese children with Henoch-Schönlein purpura: A retrospective study.

Medicine (Baltimore) 2018 Sep;97(38):e12520

Department of Pediatrics.

To identify the risk factors for developing renal involvement and severe kidney disease in Chinese childhood Henoch-Schönlein purpura (HSP) patients.This was a retrospective study of 2731 children with HSP diagnosed between 2012 and 2015. We analyzed their demographic data, clinical manifestations, and laboratory tests retrospectively. Read More

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http://dx.doi.org/10.1097/MD.0000000000012520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160025PMC
September 2018
4 Reads

Analysis of seasonal tendencies in pediatric Henoch-Schönlein purpura and comparison with outbreak of infectious diseases.

Medicine (Baltimore) 2018 Sep;97(36):e12217

Department of Pediatrics.

Henoch-Schönlein purpura (HSP) is one of the most common vasculitis in children. This study was aimed at identifying seasonal trends and epidemiologic features of pediatric HSP patients through public data to analyze the correlation of HSP and prevalence of a specific respiratory or enteric virus.We extracted information on pediatric HSP patients categorized into 4 age groups and data on 8 respiratory and 4 enteric viruses were extracted from national data. Read More

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http://Insights.ovid.com/crossref?an=00005792-201809070-0008
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http://dx.doi.org/10.1097/MD.0000000000012217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133644PMC
September 2018
2 Reads

A case of Henoch-Schonlein Purpura with dilated coronary arteries.

Pediatr Rheumatol Online J 2018 Sep 4;16(1):54. Epub 2018 Sep 4.

Department of Pediatric Rheumatology, Children's Hospital Colorado, 13123 East 16th Avenue, B311, Aurora, CO, 80045, USA.

Background: Henoch-Schonlein Purpura (HSP) is one of the most common vasculitides of childhood, with 10-20 cases per 100,000 children. It frequently occurs following an infectious trigger and involves IgA and C3 deposition in small vessel walls. HSP is characterized by palpable purpura plus IgA deposition on biopsy, arthritis/arthralgia, renal involvement (hematuria and/or proteinuria), and/or abdominal pain. Read More

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https://ped-rheum.biomedcentral.com/articles/10.1186/s12969-
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http://dx.doi.org/10.1186/s12969-018-0270-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123917PMC
September 2018
9 Reads

Ulcerative colitis in an adult patient mimicking Henoch-Schönlein purpura: A case report.

Medicine (Baltimore) 2018 Aug;97(35):e12036

Rationale: Ulcerative colitis (UC) is one of the chronic inflammatory diseases of the intestinal tract. UC being misdiagnosed as Henoch-Schönlein purpura (HSP) in the elderly has seldom been reported about.

Patient Concerns: A 64-year-old man was admitted to the hospital with petechiae and palpable purpura in lower limbs and abdominal pain for about 1 month. Read More

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http://dx.doi.org/10.1097/MD.0000000000012036DOI Listing
August 2018
9 Reads

Adult Henolch-Schonlein purpura: multiorgan failure in the setting of a purpuric rash.

BMJ Case Rep 2018 Aug 9;2018. Epub 2018 Aug 9.

Internal Medicine, University of Tennessee at Chattanooga, College of Health Education and Professional Studies, Chattanooga, Tennessee, USA.

We report a 66-year-old man with a history of congestive heart failure, atrial fibrillation on warfarin therapy and chronic kidney disease that presented with acute dyspnoea. He had multiple palpable purpuric lesions on his bilateral lower extremities. Laboratory findings supported acute anaemia with no obvious bleeding source, supratherapeutic international normalised ratio and acute on chronic kidney injury. Read More

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http://dx.doi.org/10.1136/bcr-2018-224816DOI Listing
August 2018
3 Reads

Resolution of sinus bradycardia, high-grade heart block, and left ventricular systolic dysfunction with rituximab therapy in Henoch-Schonlein purpura.

Intern Med J 2018 07;48(7):868-871

Albany Medical Center, Albany, New York, USA.

Henoch-Schonlein purpura (HSP) is a rare, typically self-limited, multi-organ vasculitis. Cardiac involvement with HSP carries high morbidity and mortality, thus requiring early aggressive immunosuppressive therapy. We report a case of HSP complicated with acute systolic left ventricular (LV) dysfunction, symptomatic sinus bradycardia and high-grade atrio-ventricular (AV) heart block. Read More

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http://dx.doi.org/10.1111/imj.13948DOI Listing
July 2018
1 Read

Neutrophil-to-lymphocyte ratio to predict gastrointestinal bleeding in Henoch: Schönlein purpura.

Pediatr Int 2018 Sep 5;60(9):791-795. Epub 2018 Sep 5.

Department of Pediatrics, Chonnam National University Hospital, Gwangju, Korea.

Background: Henoch-Schönlein purpura (HSP) is a common form of vasculitis in children. It typically involves small vessels of the skin, the gastrointestinal (GI) tract, joints, and kidneys. GI involvement is the most severe short-term complication and GI bleeding is a major complication of HSP, but there is no established predictive marker of GI bleeding. Read More

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http://dx.doi.org/10.1111/ped.13652DOI Listing
September 2018
8 Reads

Ten-year Nationwide Population-based Survey on the Characteristics of Children with Henoch-Schӧnlein Purpura in Korea.

J Korean Med Sci 2018 Jun 14;33(25):e174. Epub 2018 May 14.

Department of Pediatrics, Inje University College of Medicine, Seoul, Korea.

Background: Henoch-Schӧnlein purpura (HSP) is a common vasculitis of childhood. Though HSP is usually self-limiting, severe complications can occur. The management for this condition has not been established yet. Read More

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http://dx.doi.org/10.3346/jkms.2018.33.e174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000599PMC
June 2018
3 Reads

The Spectrum of Biopsy-Proven Glomerular Diseases among Children in China: A National, Cross-Sectional Survey.

Clin J Am Soc Nephrol 2018 Jul 18;13(7):1047-1054. Epub 2018 Jun 18.

The National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Renal Division, Nanfang Hospital and

Background And Objectives: High-quality epidemiologic data on the spectrum of biopsy-proven glomerular diseases among children are limited. This study aimed to determine the profile of and temporal change in biopsy-proven pediatric glomerular diseases in China.

Design, Setting, Participants, & Measurements: We previously conducted a nationwide kidney biopsy survey including 71,151 patients over an 11-year period from January 2004 to December 2014. Read More

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http://dx.doi.org/10.2215/CJN.11461017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032591PMC
July 2018
31 Reads

Chinese herbal medicine for the treatment of Henoch-Schönlein purpura nephritis in children: A prospective cohort study protocol.

Medicine (Baltimore) 2018 Jun;97(24):e11064

Affiliated Hospital of Liaoning University of Traditional Chinese Medicine.

Introduction: Henoch-Schönlein purpura nephritis (HSPN) involves the renal impairment of Henoch-Schönlein purpura and can easily relapse into life-threatening late nephropathy in severe cases. Although there is a lack of validated evidence for its effectiveness, Chinese herbal medicine (CHM) is one of the most commonly used methods in China to treat HSPN. It is thus need to report the protocol of a prospective cohort trial using CHM to investigate the effectiveness, safety and advantages for children with HSPN. Read More

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http://dx.doi.org/10.1097/MD.0000000000011064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024032PMC
June 2018
8 Reads
5.720 Impact Factor

Reply to the letter: "Can such an animal model truly represent Henoch-Schönlein purpura?"

Arch Dermatol Res 2018 08 1;310(6):535-536. Epub 2018 Jun 1.

Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Beijing, People's Republic of China.

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http://dx.doi.org/10.1007/s00403-018-1839-3DOI Listing
August 2018
3 Reads

Unusual presentation of Henöch-Schonlein purpura.

BMJ Case Rep 2018 May 30;2018. Epub 2018 May 30.

Bedford Hospital NHS Trust, Bedford, UK.

We present a rare case of a 4-year-old boy with newly diagnosed Henöch-Schonlein purpura (HSP) affecting the scrotum and penis. The patient presented to the emergency department with palpable purpura symmetrically distributed over the lower limbs. This was associated with arthritis of the right knee, abdominal pain and scrotal swelling. Read More

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http://dx.doi.org/10.1136/bcr-2017-220129DOI Listing
May 2018
3 Reads

[Clinical effect and mechanism of hemoperfusion in treatment of children with severe abdominal Henoch-Schönlein purpura].

Zhongguo Dang Dai Er Ke Za Zhi 2018 May;20(5):378-382

Department of Nephrology, Anhui Provincial Children′s Hospital, Hefei 230051, China.

Objective: To study the clinical effect and mechanism of hemoperfusion (HP) in the treatment of children with severe abdominal Henoch-Schönlein purpura (HSP).

Methods: A total of 24 children with severe abdominal HSP were divided into two groups: conventional treatment and HP (n=12 each). Ten healthy children who underwent physical examination were enrolled as the control group. Read More

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May 2018
4 Reads

Henoch-Schönlein purpura with acute pancreatitis: analysis of 13 cases.

BMC Pediatr 2018 05 11;18(1):159. Epub 2018 May 11.

Department of Pediatrics, First Affiliated Hospital of Anhui Medical University, 19th Floor of Medicine and Medical Tech Building, 218 Jixi Road, Hefei, 230022, Anhui, China.

Background: Henoch-Schönlein purpura is a common small vessel vasculitis in children. Acute pancreatitis rarely presents as a complication of Henoch-Schönlein purpura and has not been well characterized.

Methods: We retrospectively reviewed 13 cases of Henoch-Schönlein purpura with acute pancreatitis among 3212 patients who attended our hospital between January 2003 and June 2016 and analyzed their clinical characteristics, laboratory findings, imaging findings, treatment and overall prognosis. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-018-1142-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948829PMC
May 2018
3 Reads

Hemorrhagic bullous lesions in Henoch-Schönlein purpura: a case report and review of the literature.

BMC Pediatr 2018 05 10;18(1):157. Epub 2018 May 10.

Division of Pediatric Allergy, Immunology and Rheumatology, Department of Pediatrics, Kaohsiung Veterans General Hospital, No. 386, Dazhong 1st Road, Zuoying District, Kaohsiung City, 813, Taiwan.

Background: Henoch-Schönlein purpura (HSP) is a common vasculitis in childhood characterized by purpura, arthritis, abdominal pain and renal involvement. However, bullous HSP is a rare cutaneous manifestation, and a few cases have been reported.

Case Presentation: Herein, we report a 15-year-old male with bullous HSP who presented with severe abdominal pain and hemorrhagic bullous lesions over his lower extremities. Read More

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http://dx.doi.org/10.1186/s12887-018-1117-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944150PMC
May 2018
3 Reads

Distinct characteristics and outcomes in elderly-onset IgA vasculitis (Henoch-Schönlein purpura) with nephritis: Nationwide cohort study of data from the Japan Renal Biopsy Registry (J-RBR).

PLoS One 2018 8;13(5):e0196955. Epub 2018 May 8.

Division of Nephrology, Kanazawa Medical University School of Medicine, Ishikawa, Japan.

Background: The clinical presentation and prognosis of adult and elderly patients with IgA vasculitis (Henoch-Schönlein purpura) accompanied by nephritis (IgAV-N) have not been investigated in detail. We therefore surveyed the features and outcomes of IgAV-N based on nationwide data derived from the Japan Renal Biopsy Registry (J-RBR).

Methods: This multi-center cohort study compared the clinicopathological parameters at diagnosis, initial therapies and outcomes between 106 adult (age 19-64 years) and 46 elderly (≥65 years) patients with IgAV-N who were registered in the J-RBR between 2007 and 2012. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196955PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940189PMC
August 2018
3 Reads

Association between the functional PTPN22 G788A (R263Q) polymorphism and susceptibility to autoimmune diseases: A meta-analysis.

Cell Mol Biol (Noisy-le-grand) 2018 Apr 30;64(5):46-51. Epub 2018 Apr 30.

Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.

This study explored whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) G788A (R263Q) polymorphism is associated with susceptibility to autoimmune diseases. A meta-analysis was conducted using 23 comparative studies with a total of 16,719 patients and 17,783 controls. The meta-analysis showed an association between the A allele of the PTPN22 G788A polymorphism and decreased risk of autoimmune diseases in all subjects (p < 0. Read More

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April 2018
1 Read

Role of Direct Immunofluorescence in Cutaneous Small-Vessel Vasculitis: Experience From a Tertiary Center.

Am J Dermatopathol 2018 Sep;40(9):661-666

Departments of Histopathology.

Skin is commonly affected by vasculitic process and often subjected to biopsy. Cutaneous vasculitis can be either primary or part of a systemic vasculitic process. This study was conducted to evaluate the diagnostic utility of direct immunofluorescence (DIF) in determination of etiology of cutaneous vasculitis. Read More

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http://Insights.ovid.com/crossref?an=00000372-201809000-0000
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http://dx.doi.org/10.1097/DAD.0000000000001170DOI Listing
September 2018
16 Reads
1.430 Impact Factor

Bullous Henoch-Schönlein purpura. Case report.

Rev Chil Pediatr 2018 Feb;89(1):103-106

Facultad de Medicina, CAS, UDD, Santiago, Chile.

Henoch-Schönlein purpura (HSP) or IgA Vasculitis is the most common childhood vasculitis. The classic tetrad of signs and symptoms include palpable purpura, arthralgia, abdominal pain and renal disease. The occurrence of hemorrhagic bullae in children with HSP is rarely encountered. Read More

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http://dx.doi.org/10.4067/S0370-41062018000100103DOI Listing
February 2018
1 Read

Associations of chronic urticaria with atopic and autoimmune comorbidities: a nationwide population-based study.

Int J Dermatol 2018 Jul 16;57(7):822-829. Epub 2018 Apr 16.

Department of Health Services Administration, China Medical University, Taichung, Taiwan.

Background: Most cases of chronic urticaria (CU) are idiopathic. Circumstantial evidence suggests that some CU cases have an autoimmune pathogenesis. Previous research indicates that a substantial percentage of patients with CU have an atopic background. Read More

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http://dx.doi.org/10.1111/ijd.14000DOI Listing
July 2018
6 Reads

Incidence and risk factors for recurrent Henoch-Schönlein purpura in children from a 16-year nationwide database.

Pediatr Rheumatol Online J 2018 Apr 16;16(1):25. Epub 2018 Apr 16.

Department of Medicine, Mackay Medical College, No.45, Minsheng Rd., Tamsui Dist., New Taipei City, 25160, Taiwan.

Background: The recurrence rate of Henoch-Schönlein purpura (HSP) is 2.7%-30%, with varied average intervals between the first and second episodes. Few studies have explored the incidence and risk factors for recurrent HSP. Read More

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http://dx.doi.org/10.1186/s12969-018-0247-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902957PMC
April 2018
9 Reads

Henoch Schönlein Purpura Nephritis Developing in a Child with Known IgA Nephropathy.

Indian J Pediatr 2018 09 6;85(9):808-809. Epub 2018 Apr 6.

Fortis Institute of Renal Transplantation Sciences, Fortis Hospital, Vasant Kunj, New Delhi, India.

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http://dx.doi.org/10.1007/s12098-018-2660-xDOI Listing
September 2018
7 Reads
0.920 Impact Factor

A Unique Infusion Reaction to Vedolizumab in a Patient With Crohn's Disease.

Gastroenterology 2018 10 1;155(4):981-982. Epub 2018 Apr 1.

Department of Gastroenterology and Hepatology, New York Presbyterian Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.1053/j.gastro.2018.03.048DOI Listing
October 2018
1 Read

Gut microbiota dysbiosis is associated with Henoch-Schönlein Purpura in children.

Int Immunopharmacol 2018 May 8;58:1-8. Epub 2018 Mar 8.

Pediatric Research Institute, Qilu Children's Hospital of Shandong University, Jinan 250022, China; Shandong Children's Microbiome Center, Qilu Children's Hospital of Shandong University, Jinan 250022, China. Electronic address:

Background: Alterations in the intestinal microbiota have been associated with the development of allergic diseases, such as asthma and food allergies. However, there is no report detailing the role of microbiota alterations in Henoch-Schönlein Purpura (HSP) development.

Method: A total of 85 children with HSP and 70 healthy children were recruited for this study. Read More

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http://dx.doi.org/10.1016/j.intimp.2018.03.003DOI Listing
May 2018
5 Reads

Henoch-Schönlein purpura with major gastrointestinal involvement.

Rev Gastroenterol Peru 2017 Oct-Dec;37(4):399-400

Division of Dentistry, Armed Forces Hospital. Brasília-DF, Brazil.

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November 2018
1 Read

Epidemiology of primary systemic vasculitis in children: a population-based study from southern Sweden.

Scand J Rheumatol 2018 07 7;47(4):295-302. Epub 2018 Feb 7.

d Department of Rheumatology, Clinical Sciences Lund , Lund University , Lund , Sweden.

Objectives: To estimate the annual incidence rate of paediatric primary systemic vasculitis (PSV) in a defined geographical area in southern Sweden.

Methods: Potential cases of PSV [IgA vasculitis (IgAV, Henoch-Schönlein purpura), Kawasaki disease (KD), granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (EGPA), polyarteritis nodosa (PAN), and Takayasu's arteritis (TAK)] were identified in a comprehensive regional healthcare register. The study area is Skåne, the southernmost county of Sweden (population 1. Read More

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http://dx.doi.org/10.1080/03009742.2017.1412497DOI Listing
July 2018
10 Reads

Enteritis and Rapid-Onset Renal Dysfunction in a Previously Healthy Adult.

Gastroenterology 2018 Feb 3;154(3):e1-e3. Epub 2018 Feb 3.

University of Arizona College of Medicine, Phoenix, Arizona; Banner University Medical Center Transplant and Advanced Liver Disease Clinic, Phoenix, Arizona.

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http://dx.doi.org/10.1053/j.gastro.2017.05.028DOI Listing
February 2018
2 Reads

Genetics of immunoglobulin-A vasculitis (Henoch-Schönlein purpura): An updated review.

Autoimmun Rev 2018 Mar 17;17(3):301-315. Epub 2018 Jan 17.

Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain; School of Medicine, University of Cantabria, Santander, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Electronic address:

Immunoglobulin-A vasculitis (IgAV) is classically a childhood small-sized blood vessel vasculitis with predominant involvement of the skin. Gastrointestinal and joint manifestations are common in patients diagnosed with this condition. Nephritis, which is more severe in adults, constitutes the most feared complication of this vasculitis. Read More

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http://dx.doi.org/10.1016/j.autrev.2017.11.024DOI Listing
March 2018
6 Reads

Henoch-Schönlein purpura nephritis: initial risk factors and outcomes in a Latin American tertiary center.

Clin Rheumatol 2018 May 13;37(5):1319-1324. Epub 2018 Jan 13.

Pediatric Rheumatology Unit, Children's Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, SP, Brazil.

The objective of this study was to evaluate prevalence, initial risk factors, and outcomes in Henoch-Schönlein purpura nephritis (HSPN) patients in Latin America. Two hundred ninety-six patients (validated EULAR/PRINTO/PRES HSP criteria) were assessed by demographic data, clinical/laboratorial involvements, and treatments in the first 3 months after diagnosis. They were followed-up in a Latin American tertiary center and were divided in two groups: with and without nephritis. Read More

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http://dx.doi.org/10.1007/s10067-017-3972-3DOI Listing
May 2018
2 Reads

Location of skin lesions in Henoch-Schönlein purpura and its association with significant renal involvement.

J Am Acad Dermatol 2018 Jan;78(1):115-120

Department of Dermatology, Massachusetts General Hospital, Harvard University, Boston, Massachusetts. Electronic address:

Background: Henoch-Schönlein purpura (HSP) is a small vessel IgA-predominant vasculitis.

Objective: To describe adult patients with HSP and determine if the distribution of skin lesions (ie, purpura above the waist or purpura below the waist only), is a predictor of significant renal involvement at the time of the skin biopsy and the months following.

Methods: A retrospective study on renal function from 72 adult patients with skin-biopsy proven HSP. Read More

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http://dx.doi.org/10.1016/j.jaad.2017.04.1122DOI Listing
January 2018
16 Reads

IgA Vasculitis with Simultaneous Cardiopulmonary Involvement.

Intern Med 2018 Mar 8;57(6):829-834. Epub 2017 Dec 8.

Division of Cardiology, Department of Medicine II, Kansai Medical University, Japan.

A 60-year-old man with a history of hypertension, type 2 diabetes, and reflux esophagitis was admitted to our hospital with hemoptysis, dyspnea, and leg edema. We diagnosed him with adult IgA vasculitis based on the presence of purpura, elevated serum IgA fibronectin complexes, pathophysiological findings, a skin biopsy showing leukocytoclastic vasculitis, and immunofluorescence studies demonstrating granular IgA and C3 deposits in the blood vessel wall. He showed concurrent cardiopulmonary involvement without involvement of the gastrointestinal system and kidneys, which are commonly affected in IgA vasculitis patients. Read More

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http://dx.doi.org/10.2169/internalmedicine.9681-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891522PMC
March 2018
3 Reads

Vasculitis: Kids are not just little people.

Clin Dermatol 2017 Nov - Dec;35(6):530-540. Epub 2017 Aug 4.

Department of Dermatology Lahey Clinic, Burlington, MA.

Cutaneous vasculitis, inflammatory destruction of blood vessels, can present with a wide range of clinical and pathologic findings across a number of heterogeneous conditions. Although some vasculitides are present in both children and adults, some important differences exist in clinical presentation, etiology, management, and prognosis in childhood vasculitis versus adult vasculitis. Cutaneous vasculitis is rare in children, and most childhood vasculitides, of which Henoch-Schönlein purpura is the most common, histologically are small vessel leukocytoclastic vasculitis. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2017.08.004DOI Listing
July 2018
9 Reads

Biomarkers of IgA vasculitis nephritis in children.

PLoS One 2017 30;12(11):e0188718. Epub 2017 Nov 30.

INSERM 1149, Center of Research on Inflammation (CRI), Paris, France.

Henoch-Schönlein purpura is a systemic vasculitis characterized by IgA deposits, which target the skin, joints, and kidneys, among other organs. In children, prognosis is often good but little is known about biomarkers of pediatric nephritis. We hypothesized that biological markers, including cytokines, immunoglobulins, IgA-immune complexes, IgA glycosylation and neutrophil gelatinase-associated lipocalin (NGAL), may discriminate IgA vasculitis (IgAV) pediatric patients with renal involvement from those without renal involvement. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0188718PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708800PMC
December 2017
46 Reads

Urinary metal and metalloid biomarker study of Henoch-Schonlein purpura nephritis using inductively coupled plasma orthogonal acceleration time-of-flight mass spectrometry.

Talanta 2018 Feb 11;178:728-735. Epub 2017 Oct 11.

College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, PR China; Center for Advanced Analysis and Computational Science, Zhengzhou University, Zhengzhou 450001, PR China. Electronic address:

To obtain a better understanding as to whether concentration alterations of metals and metalloids in urine were related to Henoch-Schonlein purpura nephritis (HSPN), the profiles of as many as 29 elements in urine were compared among three groups, the Henoch-Schonlein purpura (HSP), HSPN and a healthy control group. To this end, a reliable method has been developed for the simultaneous quantification of multiple elements including Li, Be, B, Al, Sc, Ti, V, Cr, Mn, Fe, Ni, Co, Cu, Zn, Ga, Ge, As, Se, Rb, Sr, Mo, Cd, Sn, Sb, Cs, Ba, Tl, Pb and Bi in urine using inductively coupled plasma orthogonal acceleration time-of-flight mass spectrometry (ICP-oa-TOF-MS). The process of sample pre-treatment used a direct 20-fold dilution method with centrifuged urine. Read More

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http://dx.doi.org/10.1016/j.talanta.2017.10.013DOI Listing
February 2018
16 Reads

Clinical significance of the serum biomarker index detection in children with Henoch-Schonlein purpura.

Clin Biochem 2018 Feb 10;52:167-170. Epub 2017 Nov 10.

School of Medical Laboratory, Tianjin Medical University, No.1 Guangdong Road, Hexi District, Tianjin 300203, China. Electronic address:

Objective: To explore a panel of serum biomarkers for laboratory diagnosis of pediatric Henoch-Schönlein purpura (HSP).

Methods: The blood white blood cells (WBC) and serum levels of serum amyloid A (SAA), interleukin 6 (IL-6), immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), immunoglobulin E (IgE), C-reactive protein (CRP), complement component 3 (C3), complement component 4 (C4), and ASO (anti-streptolysin O) were detected in 127 patients with Henoch-Schonlein purpura (HSP), 110 cases of septicemia patients, and 121 healthy volunteers. The diagnostic ability of biomarkers selected from HSP and septicemia patients was analyzed by ROC curve. Read More

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http://dx.doi.org/10.1016/j.clinbiochem.2017.11.006DOI Listing
February 2018
25 Reads

Kidney Injury Molecule-1 Level is Associated with the Severity of Renal Interstitial Injury and Prognosis in Adult Henoch-Schönlein Purpura Nephritis.

Arch Med Res 2017 Jul 6;48(5):449-458. Epub 2017 Nov 6.

Department of Nephrology, Qilu Hospital of Shandong University, Jinan, China. Electronic address:

Background And Aims: Kidney injury molecule-1 (KIM-1) was identified the most highly upregulated protein in chronic kidney diseases and prolonged KIM-1 expression may be maladaptive. The present study was aimed to investigate urinary, renal and plasma KIM-1 levels and to analyze association between KIM-1 levels with clinical and pathological indexes in adult Henoch-Schönlein purpura (HSP) patients.

Methods: Twenty healthy individuals, 20 HSP patients without nephritis and 35 HSP patients with nephritis were recruited. Read More

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http://dx.doi.org/10.1016/j.arcmed.2017.10.005DOI Listing
July 2017
18 Reads

Imaging findings in systemic childhood diseases presenting with dermatologic manifestations.

Clin Imaging 2018 May - Jun;49:17-36. Epub 2017 Oct 31.

Department of Radiology, Division of Pediatric Radiology, Montefiore Medical Center, Bronx, NY, United States. Electronic address:

Purpose: Many childhood diseases often present with skin abnormalities with which radiologists are largely unfamiliar. Knowledge of associated dermatologic manifestations may aid the radiologist in confirming the diagnosis and recommending targeted imaging of affected organs.

Methods: We review the imaging findings in childhood diseases associated with dermatologic manifestations. Read More

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http://dx.doi.org/10.1016/j.clinimag.2017.10.015DOI Listing
September 2018
18 Reads

Differences between adult and pediatric onset Henoch-Schonlein purpura from North India.

Int J Rheum Dis 2018 Jan 8;21(1):292-298. Epub 2017 Nov 8.

Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, Uttar Pradesh, India.

Aim: Henoch-Schönlein purpura (HSP), a primary vasculitis, characterized by purpura, abdominal pain, arthritis and renal involvement, is predominantly a disease of childhood. However, rarely it can occur in adults in whom it is believed to be a more severe form with poor renal outcomes. We aimed to answer if the age of onset affected the clinical spectrum and renal outcomes of the disease in a north Indian population. Read More

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http://dx.doi.org/10.1111/1756-185X.13221DOI Listing
January 2018
6 Reads
1.770 Impact Factor

Dapsone treatment is efficient against persistent cutaneous and gastrointestinal symptoms in children with Henoch-Schönlein purpura.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2018 Jun 2;162(2):154-158. Epub 2017 Nov 2.

Department of Pediatrics, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic.

Background: Henoch-Schönlein purpura (HSP) is a systemic disorder characterized by leukocytoclastic vasculitis involving the capillaries and by the deposition of IgA immune complexes. An association between HSP and atypical bacteria is uncommon in children.

Methods And Results: Here we report three cases of children, aged 5, 4 and 16 years, who were diagnosed with HSP associated with Mycoplasma pneumoniae or Chlamydia pneumoniae infection. Read More

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http://dx.doi.org/10.5507/bp.2017.044DOI Listing
June 2018
14 Reads

Dapsone as a potential treatment option for Henoch-Schönlein Purpura (HSP).

Med Hypotheses 2017 Oct 17;108:42-45. Epub 2017 Jul 17.

Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Pediatric Nephrology, Severance Children's Hospital, Seoul, Republic of Korea; Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Henoch-Schönlein Purpura (HSP, IgA vasculitis) is an immunoglobulin A (IgA) mediated disorder characterized by systemic vasculitis with variable presentation, frequently affecting the skin, mucous membrane, joints, kidneys, and rarely lungs and the central nervous system. Interestingly, enhanced production of interleukin-8 (IL-8) levels are found during active disease and increased levels have been reported in supernatants from human umbilical venous endothelial cells after stimulation with sera from patients affected by HSP. While corticosteroid therapy is currently the recommended treatment for HSP, dapsone, an anti-leprosy agent, has also recently been suggested to have therapeutic efficacy due to its ability to suppress IL-8. Read More

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http://dx.doi.org/10.1016/j.mehy.2017.07.018DOI Listing
October 2017
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New insights in the pathogenesis of immunoglobulin A vasculitis (Henoch-Schönlein purpura).

Autoimmun Rev 2017 Dec 14;16(12):1246-1253. Epub 2017 Oct 14.

Department of Molecular Cell Biology and Immunology, VU University Medical Center, De Boelelaan 1109, 1081 HZ Amsterdam, The Netherlands; Amsterdam Infection & Immunity Institute, Amsterdam, The Netherlands; Department of Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. Electronic address:

Immunoglobulin A vasculitis (IgAV), also referred to as Henoch-Schönlein purpura, is the most common form of childhood vasculitis. The pathogenesis of IgAV is still largely unknown. The disease is characterized by IgA1-immune deposits, complement factors and neutrophil infiltration, which is accompanied with vascular inflammation. Read More

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http://dx.doi.org/10.1016/j.autrev.2017.10.009DOI Listing
December 2017
34 Reads

Clinical significance of fecal calprotectin for the early diagnosis of abdominal type of Henoch-Schonlein purpura in children.

Clin Rheumatol 2018 Jun 10;37(6):1667-1673. Epub 2017 Oct 10.

Department of Pediatric Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110004, China.

The objective of this study is to explore the value of fecal calprotectin (FC) for early screening of the abdominal type of Henoch-Schonlein purpura (AHSP) in children. The study cohort included 40 children with AHSP treated at Shengjing Hospital of China Medical University from November 2014 to November 2015, and 40 children hospitalized in the Division of Pediatric Orthopedics in the corresponding period were selected as a control group. Fresh fecal samples were collected in the acute phase of the first visit (FC1), 3 days after treatment (FC2), and 7 days after treatment (FC3) from the AHSP group and the control group. Read More

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http://dx.doi.org/10.1007/s10067-017-3864-6DOI Listing
June 2018
17 Reads

The relationship between red cell distribution width and the risk of Henoch-Schönlein purpura nephritis.

Br J Biomed Sci 2018 Jan 9;75(1):30-35. Epub 2017 Oct 9.

a Department of Clinical Laboratory , Guangxi Medical University First Affiliated Hospital , Nanning , China.

Introduction: Red blood cell distribution width (RDW) is elevated in various inflammatory diseases, but its clinical significance in Henoch-Schönlein purpura nephritis (HSPN) in unknown. The aim of this study was to determine the value of RDW as a risk factor or marker for HSPN in children.

Methods: This was a case-control study of 105 Henoch-Schönlein purpura (HSP) patients, 120 HSPN patients and 192 healthy controls. Read More

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https://www.tandfonline.com/doi/full/10.1080/09674845.2017.1
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http://dx.doi.org/10.1080/09674845.2017.1368184DOI Listing
January 2018
5 Reads

Direct immunofluorescence testing in vasculitis-A single institution experience with Henoch-Schönlein purpura.

J Cutan Pathol 2018 Jan 8;45(1):16-22. Epub 2017 Nov 8.

Departments of Pathology and Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio.

Background: Direct immunofluorescence (DIF) panels (IgG, IgA, IgM, C3 and fibrinogen) are ordered for clinically suspected vasculitis, with frequently negative results.

Methods: Cases submitted for DIF and histology (2010-2014) with "vasculitis" in the clinical data were examined, and the electronic medical record reviewed for clinical suspicion of Henoch-Schönlein purpura (HSP). Peri/intravascular IgA was considered positive, other reactants non-specific and no immunoreactivity negative. Read More

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http://dx.doi.org/10.1111/cup.13054DOI Listing
January 2018
10 Reads

Analysis on kidney injury-related clinical risk factors and evaluation on the therapeutic effects of hemoperfusion in children with Henoch-Schonlein purpura.

Eur Rev Med Pharmacol Sci 2017 Oct;21(17):3894-3899

Department of Pediatrics, Yantaishan Hospital, Yantai, Shandong, China.

Objective: To investigate risk factors related to kidney injury in children with Henoch-Schonlein purpura (HSP) and to study the therapeutic effects of hemoperfusion (HP) on kidney injury in HSP children, providing clinical evidence for early prevention and treatment of HSP.

Patients And Methods: Children who suffered from HSP for the first time were selected as study objects and they were followed up for 12 months. Single factor analysis and multi-factor Logistic regression analysis were performed for children's demographic characteristics (age, gender), clinical manifestations (rash duration time, rash recurrence times, digestive tract hemorrhage, abdominal pain, arthralgia, HSP recurrence) and laboratory indexes (peripheral blood WBC, PLT, ESR, CRP, serum IgG, serum IgA, IgM, serum C3, serum C4, TC, TG, HDL, LDL). Read More

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October 2017
4 Reads