JAMA 2017 Jun;317(22):2329-2330

Division of Rheumatology, Department of Medicine, University of Toledo, Toledo, Ohio4now with Division of Rheumatology, Department of Medicine, University of Michigan, Ann Arbor.

Medicine (Baltimore) 2017 Jun;96(23):e7091

aDepartment of Clinical Laboratory bDepartment of Nephrology, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China.

To investigate whether red blood cell distribution width (RDW) is a marker of the risk of Henoch-Schonlein purpura (HSP) nephritis (HSPN), a total of 669 HSP patients and 168 healthy controls were included in this retrospective study. Two hundred fifty-six (38.3%) of the patients had kidney involvement. Read More

Pan Afr Med J 2017 14;26:138. Epub 2017 Mar 14.

Université du Centre, Tunisie.

Clinical manifestation, etiology and outcome of leukocytoclastic vasculitis are little studied. The aim of our study was to examine epidemiological, clinical etiological, and evolutionary characteristics of this entity. We conducted a cross-sectional data collection from medical records of 85 patients with leukocytoclastic vasculitis in the Department of Dermatology at the Farhat Hached University Hospital, Sousse between January 2000 and December 2013. Read More

N Engl J Med 2017 05;376(19):1868-1877

From the Departments of Medicine (E.M.M., J.H.S.) and Pathology (A.P.M.), Massachusetts General Hospital, and the Departments of Medicine (E.M.M., J.H.S.) and Pathology (A.P.M.), Harvard Medical School - both in Boston.

Zhongguo Dang Dai Er Ke Za Zhi 2017 Apr;19(4):385-388

Department of Gastroenterology, Wuhan Children's Hospital, Wuhan 430016, China

Objective: To study the association between the single nucleotide polymorphisms (SNPs) of the ninth exon Val279Phe of platelet-activating factor acetylhydrolase (PAF-AH) gene and gastrointestinal bleeding in children with Henoch-Schönlein purpura (HSP).

Methods: A total 516 children with HSP were enrolled, among whom 182 had gastrointestinal bleeding and 334 had no gastrointestinal bleeding. PCR was used to investigate the distribution of genotypes and alleles in the SNPs of Val97Phe. Read More

Zhongguo Dang Dai Er Ke Za Zhi 2017 Mar;19(3):296-302

Department of Pediatrics, Xi'an Central Hospital, Xi'an 710003, China.

Objective: To investigate the association between CTLA-4 gene polymorphism and Henoch-Schönlein purpura (HSP) in children.

Methods: Sixty children who were diagnosed with HSP were enrolled as the case group, consisting of 33 males and 27 females. Thirty healthy children were enrolled as the control group. Read More

Zhongguo Dang Dai Er Ke Za Zhi 2017 Mar;19(3):292-295

Department of Pediatrics, Baoding Children's Hospital, Baoding, Hebei 071000, China.

Objective: To examine the changes in 25-hydroxyvitamin D3 [25-(OH)D3] level in children with Henoch-Schönlein purpura (HSP) and its clinical significance.

Methods: A total of 92 HSP children were included in this study, and were divided into HSP nephritis (HSPN) group (31 cases) and HSP group (61 cases) based on the presence or absence of HSPN. Alternatively, the patients were divided into purpura alone group (22 cases), purpura with joint symptoms group (joint symptom group, 24 cases), purpura with gastrointestinal symptoms group (gastrointestinal symptom group, 20 cases), and purpura with joint and gastrointestinal symptoms (mixed group, 26 cases) based on their clinical symptoms. Read More

Pediatr Rheumatol Online J 2017 Mar 4;15(1):15. Epub 2017 Mar 4.

Department of Nephrology and Rheumatology, Shanghai Children's Hospital, Shanghai Jiao Tong University, 355 Luding Road, Shanghai, 200062, People's Republic of China.

Background: In children with Henoch-Schonlein purpura nephritis (HSPN), the degree of proteinuria has been proven to be not only a sign of kidney damage, but also an accelerator of kidney disease progression. Nephrotic proteinuria at disease onset has been proposed as a predictor of a poor renal outcome. This study aims to assess the clinical and pathological features of HSPN with nephrotic proteinuria in a single center. Read More

Intern Med 2017 1;56(5):541-544. Epub 2017 Mar 1.

Department of Nephrology, Showa General Hospital, Japan.

Henoch Schönlein purpura (HSP), also known as IgA vasculitis (IgAV), is a systemic small-vessel vasculitis that predominantly affects adolescents and is rare in adults. In many cases, the onset of HSP has been causally linked to an infectious disease. We encountered a case of HSP with severe renal involvement diagnosed by renal biopsy following bacillus Calmette-Guerin (BCG) therapy for bladder cancer. Read More

Zhonghua Xue Ye Xue Za Zhi 2017 Jan;38(1):60-64

Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.

Objective: To explore age-based clinical and immune parameters in Henoch-Schönlein purpura (HSP) to determine clinically useful markers reflecting disease characteristic. Methods: A cohort of 502 patients with HSP were enrolled into this retrospective study to evaluate their clinical and immune data. Results: Majority HSP cases occurred at age ≤14 years and showed significant immune imbalances of ESR, CD3(+) cells, CD4(+) cells, CD3(-)CD16(+)CD56(+) cells, CD4(+)/CD8(+) cells, IgG, IgA, IgM, IgE, complements C3/C4 and ASO in the acute phase. Read More

Cutis 2017 Jan;99(1):E20-E22

Service de Dermatologie, Centre Hospitalier Universitaire, Besançon, France.

Am J Case Rep 2017 Feb 8;18:136-142. Epub 2017 Feb 8.

Department of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

BACKGROUND Henoch-Schönlein purpura (HSP), a small vessel vasculitis mediated by deposition of immune-complexes containing IgA in the skin, gut, and glomeruli, often presents with abdominal pain, purpuric rash in the lower extremities and buttocks, joint pain, and hematuria. The disease most commonly targets children but can affect adults who tend to have a worse prognosis. CASE REPORT We discuss a case of HSP in an elderly Chinese male who presented with severe proximal bowel inflammation, vasculitic rash, and proteinuria; he was found to have positive stool rotavirus and giardia. Read More

Iran J Kidney Dis 2016 Jan;11(1):12-17

Department of Nephrology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.

Introduction: Henoch-Schönlein purpura nephritis (HSPN) mainly affects children and is less common in adults, but its associated pathological changes are severe in adults, in whom it results in a poor prognosis. This study aimed to analyze the clinical and pathological characteristics of HSPN in adults and to identify the correlations among them.

Materials And Methods: Clinical and pathological data from139 patients older than 18 years of age who had been diagnosed with HSPN and had received renal biopsy at our center from January 2012 to November 2014 were collected and were grouped according to the different conditions and analyzed retrospectively. Read More

Clin Rheumatol 2017 Mar 6;36(3):729-733. Epub 2017 Feb 6.

Nephrology Center, Toranomon Hospital, 2-2-2, Toranomon, Minato, Tokyo, 105-8470, Japan.

A 41-year-old man was referred to our hospital for the evaluation of hypergammaglobulinemia (IgG 2898 mg/dL and IgA 587 mg/dL), inflammation (CRP 6.7 mg/dL and serum interleukin-6 (IL-6) 15.1 ng/L), and anemia (Hb 10. Read More

Scott Med J 2017 Feb 2;62(1):34-37. Epub 2017 Feb 2.

3 Community Regional College of Chapecó, Brazil.

Introduction Henoch-Schönlein purpura is a multisystem small vessel vasculitis. Neurologic manifestations are uncommon. Posterior reversible encephalopathy syndrome is a rare complication of Henoch-Schönlein purpura with typical clinical and neuroimaging findings that occurs most commonly in the setting of severe hypertension and renal injury. Read More

Pediatr Rheumatol Online J 2017 Jan 14;15(1). Epub 2017 Jan 14.

Department of Pediatrics B, Meyer Children's Hospital, Rambam Medical Center, Haifa, Israel.

Background: Although Henoch-Schonlein purpura (HSP) is the most common form of systemic vasculitis in children, the long term effect of HSP on endothelial function is still not clear. The aim of our study was to evaluate the long term effect of HSP on endothelial function in children and adolescents.

Methods: This research was an observational prospective study. Read More

Indian J Pharmacol 2016 Nov-Dec;48(6):739-740

Department of Nephrology, Serdang Hospital, Kajang, Selangor, Malaysia.

Ibuprofen is a nonsteroidal anti-inflammatory drug that is used widely in treating pain, fever, and inflammation. Its side effects are mainly due to acute renal impairment and gastric discomfort. We hereby report a rare case of Henoch-Schönlein purpura nephritis secondary to ibuprofen consumption which has not been reported in literature before. Read More

Ann R Coll Surg Engl 2017 Feb 4;99(2):e88-e90. Epub 2017 Jan 4.

Lancashire Teaching Hospitals NHS Foundation Trust , UK.

A 52-year-old man presented with a purpuric rash affecting his legs and hypertension. He was diagnosed with Henoch-Schönlein purpura and discharged with non-steroidal anti-inflammatory drugs. Three weeks later, he presented again with loss of appetite and vomiting before developing abdominal pain with pyrexia of 38. Read More

Wiad Lek 2016;69(5):711-713

Katedra i Klinika Nefrologii, Dializoterapii i Chorób Wewnętrznych WUM, Warszawa, Polska.

IgA vasculitis (Schönlein-Henoch purpura) is a systemic inflammation of the small vessels associated with the deposition of IgA antibodies in the vascular wall. Typical clinical symptoms are: skin lesions (purpura), joint pain, abdominal discomfort and renal disorder (most common haematuria/proteinuria). The disease affects usually the pediatric population; in those patients its course is benign and usually not associated with permanent complications. Read More

J Clin Rheumatol 2017 Jan;23(1):60-62

Department of Internal Medicine, Graduate School, Kyung Hee University, College of Medicine, Kyung Hee University Hospital at Gangdong, Seoul, South Korea Division of Rheumatology, Department of Internal Medicine, Kyung Hee University, College of Medicine, Kyung Hee University Medical Center, Seoul, South Korea Division of Rheumatology, Department of Internal Medicine, Kyung Hee University, College of Medicine, Kyung Hee University Hospital at Gangdong, Seoul, South Korea Division of Rheumatology, Department of Internal Medicine, Kyung Hee University, College of Medicine, Kyung Hee University Medical Center, Seoul, South Korea Division of Rheumatology, Department of Internal Medicine, Kyung Hee University, Kyung Hee University Hospital at Gangdong, Seoul, South Korea Division of Rheumatology, Department of Internal Medicine, Kyung Hee University, College of Medicine, Kyung Hee University Medical Center, Seoul, South Korea Division of Rheumatology, Department of Internal Medicine, Kyung Hee University, College of Medicine, Kyung Hee University Hospital at Gangdong, Seoul, South Korea

Rheumatology (Oxford) 2017 Mar;56(3):390-398

Pediatric Rheumatology Section, Department of Pediatrics, University of Santo Tomas Hospital, Manila, Philippines.

Objectives.: To examine the descriptive epidemiology of the patient population referred to paediatric rheumatology centres (PRCs) in Southeast Asia (SEA) and to compare the frequency of conditions encountered with other PRC populations.

Methods. Read More