5,220 results match your criteria Henoch-Schonlein Purpura


The efficacy and safety of immunosuppressive agents plus steroids compared with steroids alone in the treatment of Henoch-Schönlein purpura nephritis: A meta-analysis.

Int Urol Nephrol 2019 Apr 15. Epub 2019 Apr 15.

Division of Nephrology, Department of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Background: Henoch-Schönlein purpura nephritis (HSPN) is the most severe symptom of Henoch-Schönlein purpura. The role of immunosuppressive agents combined with steroids is controversial in treating HSPN. Our meta-analysis was performed to assess the efficacy and safety of the combined therapy in the treatment of HSPN compared with steroids alone. Read More

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http://dx.doi.org/10.1007/s11255-019-02092-7DOI Listing
April 2019
1 Read

[Adult IgA vasculitis (Henoch-Schönlein purpura)].

Nephrol Ther 2019 Apr;15 Suppl 1:S13-S20

Service de néphrologie et de transplantation, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France; Inserm U1149, CRI, faculté de médecine Xavier-Bichat, 16, rue Henri-Huchard, 75018 Paris, France. Electronic address:

IgA vasculitis is a systemic vasculitis affecting small vessels. IgA vasculitis usually affect children whereas it is rare in adults (150 to 200 for 1) in which the disease is often more serious with more frequent and severe nephritis. Prevalence of adult IgA vasculitis is unknown and its annual incidence is 1 in 1 million. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17697255193000
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http://dx.doi.org/10.1016/j.nephro.2019.02.001DOI Listing
April 2019
2 Reads

IgA1 isolated from Henoch-Schonlein Purpura children promotes proliferation of human mesangial cells in vitro.

Cell Biol Int 2019 Apr 8. Epub 2019 Apr 8.

Department of Anatomy, , Anhui Medical University, Hefei, Anhui, China.

Previous studies show that the proliferation of human mesangial cells (HMCs) played a significant part in the pathogenesis of Henoch-Schönlein purpura nephritis (HSPN). The aim of this study was to explore the proliferation of HMCs induced by IgA1 isolated from sera of Henoch-Schönlein purpura (HSP) patients. HMCs were cultured in three different types of media, including IgA1 from patients with HSP (HSP IgA1 group), healthy children (healthy IgA1 group) and medium (control group). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cbin.11142
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http://dx.doi.org/10.1002/cbin.11142DOI Listing
April 2019
2 Reads

Methylprednisolone or cyclosporine a in the treatment of Henoch-Schönlein nephritis: a nationwide study.

Pediatr Nephrol 2019 Apr 6. Epub 2019 Apr 6.

Department of Pediatric Nephrology and Transplantation, New Children's Hospital, University of Helsinki and Helsinki University Hospital, Stenbäckinkatu 9, 00290, Helsinki, Finland.

Background: Optimal treatment of Henoch-Schönlein purpura nephritis (HSN) remains unclear. We evaluated outcome of pediatric HSN patients treated initially with either methylprednisolone (MP) or cyclosporine A (CyA) in Finland between 1996 and 2011.

Methods: Outcome of 62 HSN patients was evaluated by screening urine and blood samples (n = 51) or by collecting clinical parameters from medical charts until last follow-up visit (n = 11). Read More

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http://dx.doi.org/10.1007/s00467-019-04238-2DOI Listing
April 2019
2 Reads

[Renal prognosis of IgA vasculitis nephritis in adult patients: a monocentric study of 25 cases].

Pan Afr Med J 2018 4;31. Epub 2018 Sep 4.

Service de Médecine Interne A, Hopital Charles Nicolle, Tunis, Tunisie.

IgA vasculitis nephritis affects the prognosis of this disease in adult patients. This study aimed to examine the clinical characteristics of this renal involvement in adults and to identify factors influencing renal prognosis. We conducted a retrospective monocentric study of patients with histologically confirmed IgA vasculitis nephritis (rheumatoid purpura) (EULAR classification criteria) with renal involvement classified according to Pillebout classification. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.9.10594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431421PMC
April 2019
1 Read

Galactose deficient IgA1 (GD-IgA1) in skin and serum from patients with skin-limited and systemic IgA Vasculitis.

J Am Acad Dermatol 2019 Mar 19. Epub 2019 Mar 19.

Department of Translational Dermatoinfectiology, University of Münster, Münster, Germany; Department of Dermatology and Venereology, University Hospital of Halle, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany. Electronic address:

Background: IgA-vasculitis (IgAV) encompasses a systemic form involving kidneys, gut, skin or joints, and a skin-limited form. One characteristic feature of systemic IgAV is deposition of galactose-deficient IgA1 (GD-IgA1) in kidneys (as in IgA-nephropathy). The relevance of GD-IgA1 for cutaneous vasculitis is unknown. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.03.029DOI Listing
March 2019
1 Read

Chemokine Receptor 8 Can Distinguish Antineutrophil Cytoplasmic Antibody-Associated Vasculitis From Infectious Complications.

Kidney Int Rep 2019 Mar 10;4(3):447-454. Epub 2018 Nov 10.

Division of Nephrology, Japan Community Health Care Organization Sendai Hospital, Sendai, Miyagi, Japan.

Introduction: Diagnosing vasculitis is frequently difficult because its clinical symptoms are similar to those of common infectious diseases and other inflammatory disorders. This study focused on chemokine receptor 8 (CCR8) in peripheral blood mononuclear cells to find a new biomarker that distinguishes vasculitis from infectious complications.

Methods: A cross-sectional study was conducted among 113 patients with systemic vasculitis who were referred to Japan Health Care Organization Sendai Hospital from 2014 to 2016, including those with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, anti-glomerular basement membrane disease, lupus nephritis, and Henoch-Schonlein purpura. Read More

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http://dx.doi.org/10.1016/j.ekir.2018.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409406PMC
March 2019
1 Read

Urinalysis monitoring in children with Henoch-Schönlein purpura: Is it time to revise?

Int J Rheum Dis 2019 Mar 21. Epub 2019 Mar 21.

Department of Paediatric Subspecialties, Rheumatology and Immunology Service, KK Women's and Children's Hospital, Singapore, Singapore.

Objectives: To describe the natural history and risk factors of renal involvement in our Henoch-Schönlein purpura (HSP) inception cohort.

Methods: HSP patients followed at our center for at least 6 months between 1/2009-4/2017 were included. A 2-year urinalysis (UA) monitoring protocol was adopted (6 monthly and another 6 of 3 monthly UA). Read More

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http://dx.doi.org/10.1111/1756-185X.13552DOI Listing
March 2019
2 Reads

A retrospective analysis of children with Henoch-Schonlein purpura and re-evaluation of renal pathologies using Oxford classification.

Clin Exp Nephrol 2019 Mar 20. Epub 2019 Mar 20.

Department of Pediatric Nephrology, Dr. Sami Ulus Maternity and Child Health and Diseases Training and Research Hospital, Ankara, Turkey.

Background: Henoch-Schönlein purpura (HSP) is the most common vasculitis in childhood. The long-term prognosis is variable and depends on renal involvement. The aims of this study were to investigate the clinical and laboratory characteristics of our HSP patients, to identify the risk factors for the development of Henoch-Schönlein purpura nephritis (HSPN) and to assess the efficacy of the Oxford Classification system for predicting renal outcomes. Read More

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http://dx.doi.org/10.1007/s10157-019-01726-5DOI Listing
March 2019
1 Read

European consensus-based recommendations for diagnosis and treatment of immunoglobulin A vasculitis-the SHARE initiative.

Rheumatology (Oxford) 2019 Mar 16. Epub 2019 Mar 16.

Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.

Objectives: IgA vasculitis (IgAV, formerly known as Henoch-Schönlein purpura) is the most common cause of systemic vasculitis in childhood. To date, there are no internationally agreed, evidence-based guidelines concerning the appropriate diagnosis and treatment of IgAV in children. Accordingly, treatment regimens differ widely. Read More

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https://academic.oup.com/rheumatology/advance-article/doi/10
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http://dx.doi.org/10.1093/rheumatology/kez041DOI Listing
March 2019
4 Reads

[Rapid progressive glomerulonephritis].

Authors:
Marion Haubitz

Internist (Berl) 2019 Mar 13. Epub 2019 Mar 13.

Medizinische Klinik III - Nieren- und Hochdruckerkrankungen, Klinikum Fulda gAG, Universitätsmedizin Marburg - Campus Fulda, Pacelliallee 4, 36043, Fulda, Deutschland.

The rapid progressive glomerulonephritis is an emergency case. Renal function is rapidly lost within weeks or a few months (rarely within days) due to necrotizing extracapillary proliferative crescentic glomerulonephritis. Early diagnosis and treatment improve prognosis, as the best prognostic marker is creatinine when treatment is initiated. Read More

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http://link.springer.com/10.1007/s00108-019-0575-x
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http://dx.doi.org/10.1007/s00108-019-0575-xDOI Listing
March 2019
4 Reads

Analysis of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio and mean platelet volume to platelet count ratio in children with acute stage of immunoglobulin A vasculitis and assessment of their suitability for predicting the course of the disease.

Rheumatol Int 2019 Mar 13. Epub 2019 Mar 13.

Department of Paediatrics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, ul. 3-go Maja 13-15, 41-800, Zabrze, Poland.

Immunoglobulin A vasculitis (IgAV) is the most common systemic vasculitis in developmental age. The disease is most often characterized by a self-limiting course and good prognosis, but sometimes serious complications, like gastrointestinal bleeding or glomerulonephritis, may develop. The neutrophil to lymphocyte (NLR) and the platelet to lymphocyte (PLR) ratios are indicators related to clinical outcome in various inflammatory diseases. Read More

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http://dx.doi.org/10.1007/s00296-019-04274-zDOI Listing
March 2019
4 Reads

Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to Henoch-Schönlein purpura: a meta-analysis.

J Renin Angiotensin Aldosterone Syst 2019 Jan-Mar;20(1):1470320319836302

Department of Pediatrics, Hangzhou Hospital of Traditional Chinese Medicine, China.

Objective:: Meta-analysis was performed in the current study to evaluate the relationship of the angiotensin-converting enzyme insertion/deletion polymorphism with the risk of the incidence of Henoch-Schönlein purpura.

Methods:: The electronic databases, including Embase, PubMed and Google scholar, were systemically retrieved to search for related articles. Meanwhile, statistical analysis was performed using the odds ratio and the corresponding 95% confidence interval. Read More

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http://dx.doi.org/10.1177/1470320319836302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413430PMC

Exercise-Induced Purpura in Children.

Pediatrics 2019 Apr 7;143(4). Epub 2019 Mar 7.

Penn State Children's Hospital, Hershey, Pennsylvania.

Exercise-induced purpura, which has also been called "golfer's purpura," is a phenomenon that has been rarely reported in the pediatric literature. This is the first case series in which this benign vasculopathy, which is most often associated with warm weather and high-impact activity, is described. In this series, we describe 5 patients, most of whom had an erythematous purpuric rash above the sock line that extended to the knees and was associated with warm weather and prolonged activity. Read More

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http://dx.doi.org/10.1542/peds.2018-2797DOI Listing

MEFV gene mutations in children with Henoch-Schönlein purpura and their correlations-do mutations matter?

Clin Rheumatol 2019 Mar 2. Epub 2019 Mar 2.

Department of Pediatric Nephrology and Rheumatology, Dr. Sami Ulus Maternity and Child Health and Diseases Training and Research Hospital, Ankara, Turkey.

Objective: To explore the frequency of MEFV gene mutations in children with Henoch-Schönlein purpura who had no prior familial Mediterranean fever diagnosis and to evaluate the association of MEFV mutations with the clinical and laboratory features of Henoch-Schönlein purpura.

Methods: Data of 1120 patients diagnosed with Henoch-Schönlein purpura were reviewed retrospectively. The spectrum and degree of organ involvement and acute phase reactant levels were documented for each patient. Read More

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http://dx.doi.org/10.1007/s10067-019-04489-2DOI Listing
March 2019
1 Read

Different histological classifications for Henoch-Schönlein purpura nephritis: which one should be used?

Pediatr Rheumatol Online J 2019 Feb 28;17(1):10. Epub 2019 Feb 28.

Department of Pediatrics, Hacettepe University, Ankara, Turkey.

Background: Nephritis is the most important chronic complication of IgA Vasculitis (IgAV)/Henoch-Schönlein purpura (IGAV/HSP) and thus the main prognostic factor of this most common childhood vasculitis. Since the prognosis and treatment selection depends on the mode of interpretation of biopsy material, in this manuscript we have presented several issues related to the uneven application of different histological classifications in IgAV/Henoch-Schönlein purpura nephritis (HSPN). The nephritis of IgAV/IGAV/HSP will be abbreviated as HSPN for this paper. Read More

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http://dx.doi.org/10.1186/s12969-019-0311-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393980PMC
February 2019
1 Read

Incidence of pediatric glomerular diseases in Arab world: A systematic review.

Saudi J Kidney Dis Transpl 2019 Jan-Feb;30(1):15-23

Department of Allied Health Sciences, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman.

Despite the high number of Arab children, there are a scanty available data about different types of pediatric glomerular diseases in all Arab countries. Very few Arab countries have a national renal biopsy registry. In this review, we performed a systematic review analyzing the incidence of pediatric glomerular disease in all Arab countries. Read More

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February 2019
3 Reads

Pediatric Rheumatology Curriculum for the Pediatrics Resident: A Case-Based Approach to Learning.

MedEdPORTAL 2018 Oct 26;14:10767. Epub 2018 Oct 26.

Assistant Professor, Department of Pediatrics, Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine at Texas Children's Hospital.

Introduction: Pediatric rheumatologic disease occurs more frequently than several other chronic pediatric diseases but is often underrecognized. It is estimated that in the US, one in 250 children has some form of juvenile arthritis and 300,000 children have a form of rheumatologic disease. However, there are only approximately 400 practicing pediatric rheumatologists nationwide. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342410PMC
October 2018
2 Reads

Tubulointerstitial Infiltration of M2 Macrophages in Henoch-Schönlein Purpura Nephritis Indicates the Presence of Glomerular Crescents and Bad Clinical Parameters.

Biomed Res Int 2019 20;2019:8579619. Epub 2019 Jan 20.

Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea.

Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis in children, and renal involvement (HSP nephritis, HSPN) is a severe manifestation. HSPN is histologically classified by the International Study of Kidney Disease in Children (ISKDC) based on mesangial hypercellularity and the extent of glomerular crescents. Macrophages, categorized as M1 or M2, frequently infiltrate in various glomerular and tubulointerstitial diseases and infiltration of specific subtypes is associated with disease progression. Read More

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http://dx.doi.org/10.1155/2019/8579619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360621PMC
January 2019
1 Read

[Value of galactose-deficient IgA1 in the early diagnosis of Henoch-Schönlein purpura nephritis in children].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):172-175

Department of Nephrology and Rheumatology, Hunan Children's Hospital/Academy of Pediatrics of University of South China, Changsha 410007, China.

Objective: To explore the value of galactose-deficient IgA1 (Gd-IgA1) in the early diagnosis of Henoch-Schönlein purpura nephritis (HSPN) in children.

Methods: A total of 67 hospitalized children who were definitely diagnosed with HSPN between January and April 2018 and 58 hospitalized children with Henoch-Schönlein purpura (HSP) were enrolled in the study. Twenty children undergoing routine physical examinations served as controls. Read More

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February 2019
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[Clinical effect of alanyl-glutamine-enriched nutritional support in the treatment of children with abdominal Henoch-Schönlein purpura].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):168-171

Department of Pediatric Gastroenterology, Chengdu Women and Children's Central Hospital, Chengdu 610091, China.

Objective: To study the clinical effect of alanyl-glutamine-enriched nutritional support in the treatment of children with abdominal Henoch-Schönlein purpura.

Methods: Children with abdominal Henoch-Schönlein purpura who needed nutritional support were enrolled and stratified according to age, sex and the severity of disease, and were randomly divided into a control group (n=118) and an enriched nutritional support group (n=107). The control group was given nutritional support without using alanyl-glutamine, while the enriched nutritional support group was given alanyl-glutamine-enriched nutritional support. Read More

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February 2019

Food-induced IgA Vasculitis (Henoch-Schönlein Purpura).

Eur J Case Rep Intern Med 2018 22;5(2):000774. Epub 2018 Feb 22.

Internal Medicine Department, Hospital Universitario Miguel Servet, Zaragoza, Spain.

Immunoglobulin A (IgA) vasculitis is a rare entity in adults. It can be triggered by allergens such as drugs, food, or insect bites. We present a case of an adult male with a cutaneous IgA vasculitis of palpable purpura after eating canned sardines. Read More

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http://dx.doi.org/10.12890/2017_000774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346936PMC
February 2018

The clinical spectrum of Henoch-Schönlein purpura in children: a single-center study.

Clin Rheumatol 2019 Feb 8. Epub 2019 Feb 8.

Kanuni Sultan Süleyman Research and Training Hospital, Department of Pediatric Rheumatology, University of Health Science, No: 46/1, Kucukcekmece, 34303, Istanbul, Turkey.

Objectives: Henoch-Schönlein purpura (HSP) is the most common vasculitis of children. The aim of this study is to evaluate the demographic and clinic findings of patients with HSP and also to determine predictive factors for assessing the development of gastrointestinal system (GIS) and renal involvement.

Methods: This study was performed prospectively among children with HSP who are under 18 years of age and being followed-up in the Pediatric Rheumatology Unit of Health Sciences University Kanuni Sultan Süleyman Training and Research Hospital between January 2016 and January 2018. Read More

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http://dx.doi.org/10.1007/s10067-019-04460-1DOI Listing
February 2019

Clinical course & management of childhood nephrotic syndrome in Germany: a large epidemiological ESPED study.

BMC Nephrol 2019 Feb 7;20(1):45. Epub 2019 Feb 7.

Department of Radiology, Pediatric Radiology, University Hospital of Bonn, Bonn, Germany.

Background: Nephrotic syndrome (NS) is one of the most frequent occurring chronic kidney diseases in childhood, despite its rarely occurrence in the general population. Detailed information about clinical data of NS (e.g. Read More

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http://dx.doi.org/10.1186/s12882-019-1233-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367765PMC
February 2019
10 Reads

[Adult-onset Henoch-Schönlein purpura mimicking infectious enteritis].

Rinsho Ketsueki 2019;60(1):51-56

Department of Pathology, Iwate Medical University.

A 37-year-old male with chief complaints of vomiting, abdominal pain, and diarrhea presented to our hospital in June 2017. A blood test detected increased inflammatory response, and a computed tomography scan showed that wall thickening extended from the terminal ileum to the entire large intestine. Bacterial enteritis was suspected because his household members developed infectious enteritis; however, his symptoms did not improve after antibiotic treatment. Read More

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http://dx.doi.org/10.11406/rinketsu.60.51DOI Listing
January 2019
1 Read

Hemorrhagic Bullous Henoch-Schönlein Purpura: Case Report and Review of the Literature.

Front Pediatr 2018 22;6:413. Epub 2019 Jan 22.

Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany.

Henoch-Schönlein Purpura (HSP) or IgA vasculitis is the most common systemic vasculitis of childhood and may affect skin, joints, gastrointestinal tract, and kidneys. Skin manifestations of HSP are characteristic and include a non-thrombocytopenic palpable purpura of the lower extremities and buttocks. Rarely, HSP may initially present as or evolve into hemorrhagic vesicles and bullae. Read More

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https://www.frontiersin.org/article/10.3389/fped.2018.00413/
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http://dx.doi.org/10.3389/fped.2018.00413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349767PMC
January 2019
17 Reads

From Schönlein-Henoch purpura to IgA-vasculitis: pathogenetic aspects of the disease.

Ter Arkh 2018 Nov;90(10):109-114

I.M. Sechenov First Moscow State Medical University Ministry of Health of Russia (Sechenov University), Moscow, Russia.

Investigation's history and nomenclature's evolution of the IgA-vasculitis are presented in the article. Pathogenesis of the renal and skin damages is discussed in details, particularly abnormalities of the IgA-immunity and systemic endotoxemia. Relevant world's literature is cited. Read More

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http://dx.doi.org/10.26442/terarkh20189010109-114DOI Listing
November 2018
2 Reads

Imaging in small and medium vessel vasculitis.

Int J Rheum Dis 2019 Jan;22 Suppl 1:78-85

Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Vasculitis includes a group of disorders characterized by inflammation of the vessel wall and classified based on the diameter of the predominantly involved vessels. Granulomatosis with polyangiitis, microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis and Henoch-Schonlein purpura are the important entities in the small vessel vasculitis group, while polyarteritis nodosa and Kawasaki disease represent the medium vessel vasculitis group. The clinical manifestations may be non-specific and there may be considerable overlap with the other disorders. Read More

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http://dx.doi.org/10.1111/1756-185X.13390DOI Listing
January 2019
3 Reads

Leukocytoclastic vasculitis with late-onset Henoch-Schönlein purpura after trifluridine/tipiracil treatment.

Dermatol Online J 2018 Oct 15;24(10). Epub 2018 Oct 15.

Department of Dermatology, The University of Texas McGovern Medical School, Houston, Texas.

Trifluridine/tipiracil has been approved for the treatment of refractory metastatic colorectal cancer. Adverse effects of this drug combination include leukopenia, neutropenia, fatigue, diarrhea, and vomiting. We present a case of trifluridine/tipiracil-induced leukocytoclastic vasculitis (LCV) with late-onset Henoch-Schönlein purpura (HSP) in a 42-year-old man with metastatic appendiceal cancer. Read More

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October 2018
4 Reads

[Role of hypomethylation of suppressor of cytokine signaling in T helper 17 cell/regulatory T cell imbalance in children with Henoch-Schönlein purpura].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Jan;21(1):38-44

Department of Pediatric Cardiology, Nephrology and Rheumatism, Affliated Hospital of Qingdao University, Qingdao, Shandong 266003, China.

Objective: To investigate the association between suppressor of cytokine signaling (SOCS) hypomethylation and T helper 17 (Th17) cell/regulatory T (Treg) cell imbalance in children with Henoch-Schönlein purpura (HSP) and the immune pathogenesis of HSP.

Methods: A total of 32 children in the acute stage of HSP who were hospitalized from May 2014 to January 2015 were enrolled as subjects, and 28 children who underwent physical examination were enrolled as normal control group. ELISA was used to measure the plasma level of interleukin-6 (IL-6). Read More

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January 2019
1 Read

Characterization of scrotal involvement in children and adolescents with IgA vasculitis.

Adv Rheumatol 2018 Nov 3;58(1):38. Epub 2018 Nov 3.

Pediatric Rheumatology Unit, Children's Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, SP, Av. Dr. Eneas Carvalho Aguiar, 647 - Cerqueira César, São Paulo, SP, 05403-000, Brazil.

Objective: To characterize scrotal involvement in children and adolescents with IgA vasculitis.

Methods: A cross-sectional retrospective study included 296 IgA vasculitis (EULAR/PRINTO/PRES criteria) patients, 150/296 (51%) were males and assessed by demographic/clinical/laboratory and treatments. Scrotal involvement was defined by the presence of scrotal edema and/or pain/tenderness in physical examination and/or testicular Doppler ultrasound abnormalities. Read More

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http://dx.doi.org/10.1186/s42358-018-0039-3DOI Listing
November 2018

The change of Th17/Treg cells and IL-10/IL-17 in Chinese children with Henoch-Schonlein purpura: A PRISMA-compliant meta-analysis.

Medicine (Baltimore) 2019 Jan;98(3):e13991

Department of Pediatrics.

Background: To date, the relationship of Th17 and Treg cells to Henoch-Schonlein purpura (HSP) in children remains controversial. Therefore, a systematic review and meta-analysis was conducted to reveal the potential role of the Th17 and Treg cells in children in acute stage of HSP.

Methods: PubMed, Embase, Web of Science and China National Knowledge Internet (CNKI) were systematically searched for eligible studies up to November 03, 2017. Read More

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http://dx.doi.org/10.1097/MD.0000000000013991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370168PMC
January 2019
2 Reads
5.723 Impact Factor

Differential expression of long non-coding RNA and mRNA in children with Henoch-Schönlein purpura nephritis.

Exp Ther Med 2019 Jan 30;17(1):621-632. Epub 2018 Nov 30.

Department of Pediatrics, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110032, P.R. China.

Long non-coding RNAs (lncRNAs) serve an essential role in regulating immunological functions. However, their impact on Henoch-Schönlein purpura nephritis (HSPN), has remained elusive. The present study determined the expression of lncRNAs and mRNAs in the peripheral blood of 6 children with HSPN and recruited 4 healthy children for comparative study. Read More

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http://www.spandidos-publications.com/10.3892/etm.2018.7038
Publisher Site
http://dx.doi.org/10.3892/etm.2018.7038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307475PMC
January 2019
10 Reads

Acute abdominal pain: Henoch-Schönlein purpura case in a young adult, a rare but important diagnosis.

Clin Med (Lond) 2019 Jan;19(1):77-79

Royal Victoria Hospital, Belfast, UK.

Henoch-Schönlein purpura (HSP), also known as IgA vasculitis, is a systemic vasculitis which is the most common vasculitis in children. The incidence in adults varies from 3.4 to 14. Read More

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http://dx.doi.org/10.7861/clinmedicine.19-1-77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399654PMC
January 2019
3 Reads

Direct Immunofluorescence Results of the Skin Biopsy and Frequency of Systemic Involvement in Children with Henoch-Schonlein Purpura.

Fetal Pediatr Pathol 2019 Jan 2:1-6. Epub 2019 Jan 2.

b Department of Pathology , Tehran University of Medical Sciences , Tehran , Iran.

Objective: Henoch-Schonlein purpura (HSP) is a common vasculitis in children that can present with multi-organ involvement. The aim of this study is to investigate the correlation between direct immunofluorescence (DIF) results and the systemic involvements of the HSP in pediatric patients.

Material And Methods: Those HSP patients with leukocytoclastic vasculitis on their biopsies who also had documented immunoglobulin/complement deposition by DIF were included in our study. Read More

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http://dx.doi.org/10.1080/15513815.2018.1552733DOI Listing
January 2019
4 Reads

Clinicopathological profile of pediatric renal biopsies at a tertiary care hospital, Pakistan.

Saudi J Kidney Dis Transpl 2018 Nov-Dec;29(6):1403-1409

The Kidney Center, Karachi, Pakistan.

Renal biopsy is an important tool for the diagnosis of acute and chronic glomerular diseases in children. We aimed to analyze the spectrum of clinical indications and histopathological patterns (HPP) in children who underwent renal biopsy (RB). This is a retrospective review of case records of 108 renal biopsies carried out from January 2010 to December 2015 at the Pediatric Nephrology Department, National Institute of Child Health Karachi, Pakistan. Read More

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http://www.sjkdt.org/text.asp?2018/29/6/1403/248290
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http://dx.doi.org/10.4103/1319-2442.248290DOI Listing
December 2018
15 Reads

Henoch-Schonlein purpura in pregnancy: A case report.

Obstet Med 2018 Dec 7;11(4):195-197. Epub 2018 Mar 7.

Internal Medicine Division, Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.

Henoch-Schonlein purpura is a relatively common pediatric vasculitis. Very few cases of Henoch-Schonlein purpura during pregnancy have been described. Henoch-Schonlein purpura is variable in its presentation, from completely benign to possibly catastrophic complications. Read More

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http://dx.doi.org/10.1177/1753495X17745391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295767PMC
December 2018

Acute hemorrhagic edema of infancy: guide to prevent misdiagnosis.

Cutis 2018 Nov;102(5):359-362

Department of Dermatology, Geisinger Health System, Danville, Pennsylvania, USA.

We report the case of a 10-month-old previously healthy boy who presented with acute rash, edema, and low-grade fever in the setting of recent diarrhea. We differentiate between acute hemorrhagic edema of infancy (AHEI) and Henoch-Schönlein purpura (HSP). Read More

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November 2018
14 Reads

Successful treatment of hemorrhagic bullous Henoch-Schonlein purpura with intravenous immunoglobulins.

Pediatr Dermatol 2019 Jan 18;36(1):e34-e36. Epub 2018 Dec 18.

Department of Paediatrics, Santobono-Pausilipon Children's Hospital, Naples, Italy.

Henoch-Schonlein purpura (HSP) is the most common systemic vasculitis in childhood. There is no consensus about the management for isolated cutaneous manifestations in HSP. We describe a case of HSP presenting with severe skin lesions that did not respond to standard therapy with corticosteroids. Read More

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http://dx.doi.org/10.1111/pde.13715DOI Listing
January 2019
2 Reads

Late Relapse of Henoch-Schönlein Purpura in an Adolescent Presenting as Severe Gastroduodenitis.

Front Pediatr 2018 20;6:355. Epub 2018 Nov 20.

Pediatric Department, Anna Meyer Children's Hospital, Florence, Italy.

Henoch-Schönlein purpura is a systemic vasculitis, commonly affecting children. Gastrointestinal manifestations are observed in 50-75% of patients; it is well known they may occur before skin lesions in about 20% of cases during the first vasculitic episode. Relapses occur in about one third of patients, typically within 4 months from the initial presentation and with milder symptoms. Read More

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https://www.frontiersin.org/article/10.3389/fped.2018.00355/
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http://dx.doi.org/10.3389/fped.2018.00355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256137PMC
November 2018
25 Reads

Henoch-Schönlein Purpura After Living Donor Liver Transplantation: Report of the First Case.

Transplant Proc 2018 Dec 9;50(10):4050-4052. Epub 2018 Mar 9.

Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Henoch-Schönlein purpura (HSP) is a systemic vasculitis affecting the small vessels that mainly presents in children and young adults. It is characterized by tissue deposition of immunoglobulin A (IgA) immune complexes with the classic manifestations of purpura, arthritis, arthralgia, and gastrointestinal and renal involvements. We report a case of HSP nephritis that occurred 2 years after living-donor liver transplantation (LDLT). Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.02.072DOI Listing
December 2018
3 Reads

Predisposing factors of childhood Henoch-Schönlein purpura in Anhui province, China.

J Investig Med 2019 Apr 6;67(4):771-778. Epub 2018 Dec 6.

Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Henoch-Schönlein purpura (HSP) is a common autoimmune vasculitis in childhood. The detailed pathogenesis of HSP is still unclear, whereas several types of predisposing factors have been proved to be the initial step. The objectives of present study were to analyze the distribution of predisposing factors, association of the predisposing factors with clinical manifestations and HSP relapse/recurrence. Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000906
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http://dx.doi.org/10.1136/jim-2018-000906DOI Listing
April 2019
18 Reads
1.503 Impact Factor

Henoch-schonlein Purpura Nephritis with Renal Interstitial Lesions.

Open Med (Wars) 2018 27;13:597-604. Epub 2018 Nov 27.

Institute of Pathology, Basic Medical College of Lanzhou University, Lanzhou 730000, Gansu Province, China.

Objective: To investigate the clinical pathology and prognosis & outcome of Henoch-Schonlein purpura nephritis (HSPN) with renal interstitial lesions.

Methods: All 148 patients were analyzed for clinical, renal pathological, and prognostic features. Patients with no, mild, and moderate- severe renal tubulo-interstitial lesions were included in group A, B and C, respectively. Read More

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http://dx.doi.org/10.1515/med-2018-0088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272053PMC
November 2018
8 Reads

[Effect of miR-21 on the expression of interleukin-10 in B cell of patients with Henoch-Schonlein purpura].

Zhonghua Er Ke Za Zhi 2018 Dec;56(12):939-944

Rheumatology & Immunology Department of Shenzhen Children's Hospital, Shenzhen 518038, China.

To investigate the effect of microRNAs (miR)-21 on the expression of interleukin (IL)-10 in B cell of patients with Henoch-Schonlein purpura (HSP). From March 2016 to January 2017, twenty-four children with HSP hospitalized in rheumatology and immunology department of Shenzhen Children's Hospital were enrolled into the study, including 12 males and 12 females. Patients were divided into purpura nephritis group (HSPN, 14 cases) and non-nephritis group (NHSPN, 10 cases). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2018.12.010DOI Listing
December 2018
5 Reads

MEFV gene variants in children with Henoch-Schönlein purpura and association with clinical manifestations: a single-center Mediterranean experience.

Postgrad Med 2019 Jan 12;131(1):68-72. Epub 2018 Dec 12.

a Department of Pediatric Rheumatology , Cukurova University Faculty of Medicine , Adana , Turkey.

Objectives: Henoch-Schönlein purpura (HSP) is characterized by non-thrombocytopenic palpable purpura, abdominal pain, and arthralgia/arthritis. We aimed to describe the clinical presentations of children with HSP in a single center and compare the prevalence of each manifestations between patients with MEFV variants, particularly in exon 10 and those without.

Methods: This cohort retrospectively included 144 HSP (59 females, 85 males) patients without Familial Mediterranean Fever (FMF) symptoms and followed for at least 6 months. Read More

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http://dx.doi.org/10.1080/00325481.2019.1552479DOI Listing
January 2019
10 Reads

Atypical purpura location in a pediatric patient with Henoch-Schönlein purpura: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13294

Department of Laboratory, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Rationale: The presence of purpura is a compulsory criteria for the diagnosis of Henoch-Schönlein purpura (HSP). Typical purpura of HSP is distributed symmetrically over the extensor surfaces of the lower limbs, buttocks, and forearms with the occasional involvement of trunk and face in children. It occurs only involving the bottom of the feet has never been reported. Read More

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http://dx.doi.org/10.1097/MD.0000000000013294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283069PMC
November 2018
10 Reads

Features distinguishing juvenile idiopathic arthritis among children with musculoskeletal complaints.

World J Pediatr 2018 Nov 29. Epub 2018 Nov 29.

Division of Rheumatology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.

Background: Musculoskeletal (MSK) complaints in children vary, ranging from benign, self-limited conditions to serious disorders. Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease, initially presenting with MSK complaints. Delayed diagnosis and appropriate treatment have an enormous impact on the long-term outcomes and the level of disability. Read More

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http://dx.doi.org/10.1007/s12519-018-0212-0DOI Listing
November 2018
5 Reads

Cardiovascular, thromboembolic and renal outcomes in IgA vasculitis (Henoch-Schönlein purpura): a retrospective cohort study using routinely collected primary care data.

Ann Rheum Dis 2019 Feb 28;78(2):261-269. Epub 2018 Nov 28.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK.

Background: IgA vasculitis (IgAV, Henoch-Schönlein purpura) is a small-vessel vasculitis most common in children but also occurring in adults. Case series have suggested that IgAV may be associated with cardiovascular disease and venous thromboembolism, but this has not been evaluated in population-based studies. Renal disease and hypertension are possible complications of the disease with unknown incidence. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214142DOI Listing
February 2019
7 Reads

Intussusception as the main manifestation of Schönlein-Henoch purpura in an adult patient.

Gastroenterol Hepatol 2018 Nov 24. Epub 2018 Nov 24.

Servicio de Medicina Interna, Hospital Universitari del Sagrat Cor, Barcelona, España.

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http://dx.doi.org/10.1016/j.gastrohep.2018.09.009DOI Listing
November 2018
1 Read