6,542 results match your criteria Henoch-Schonlein Purpura

Acute rheumatic fever in adult patients.

Medicine (Baltimore) 2022 Jul 1;101(26):e29833. Epub 2022 Jul 1.

Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.

Acute rheumatic fever (ARF) is considered as a disorder of children, and attacks in adults are usually a recurrence of disease acquired in the child's life. Although the incidence of ARF in children has a decreasing trend in developed countries, resurgent and sporadic epidemics still occur in adults. The first attacks of ARF in adult patients without a childhood history can lead to a diagnostic dilemma. Read More

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Henoch-Schonlein Purpura in a Newly Diagnosed HIV Patient.

Eur J Case Rep Intern Med 2022 4;9(5):003363. Epub 2022 May 4.

Morsani College of Medicine, University of South Florida, FL, USA.

HIV infection is associated with multisystemic manifestations due both to secondary infections caused by a decrease in the CD4+ T-cell count and to the pathogenicity of the HIV virus itself. A common renal manifestation is HIV-associated nephropathy, which is frequently seen in the African population with the APOL1 gene mutation; however, other forms of glomerulopathy such as IgA nephropathy, commonly noted in other ethnicities, are also seen. Vasculitis has rarely been associated with HIV infection and mainly involves small blood vessels, although any size of blood vessel may be involved. Read More

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A case of successful late steroid withdrawal after ABO-incompatible kidney transplantation.

Korean J Transplant 2020 Jun;34(2):121-125

Department of Internal Medicine, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, Korea.

Few data exist regarding steroid withdrawal in ABO-incompatible (ABO-i) kidney transplantation (KT). Here, we report a case of steroid withdrawal after ABO-i KT. A 46-year-old man diagnosed with Henoch-Schonlein purpura received ABO-i KT from his 42-year-old sister. Read More

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The role of Dendrin in IgA Nephropathy.

Nephrol Dial Transplant 2022 Jun 29. Epub 2022 Jun 29.

Department of Clinical Science, Intervention and Technology, Divison of Renal Medicine Karolinska Institutet, Stockholm, Sweden.

Background: IgA nephropathy (IgAN) and its systemic variant IgA vasculitis (IgAV) damage the glomeruli, resulting in proteinuria, hematuria and kidney impairment. Dendrin is a podocyte-specific protein suggested to be involved in the pathogenesis of IgAN. Upon cell injury, dendrin translocates from the slit diaphragm to the nucleus where it is suggested to induce apoptosis and cytoskeletal changes, resulting in proteinuria and accelerated disease progression in mice. Read More

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Hypocomplementemic Atypical IgA Vasculitis: A Case Report.

Front Pediatr 2022 9;10:886371. Epub 2022 Jun 9.

Department of Pediatric Nephrology, Children's Hospital Colorado, Aurora, CO, United States.

IgA vasculitis (IgAV, also known as Henoch-Schönlein purpura or HSP) is a vasculitis of small vessels involving multiple organs, particularly of the joints, gastrointestinal tract, skin, and kidneys. Growing laboratory evidence has shown that complement plays a key role in the pathogenesis of IgAV, although direct evidence of this association in patients is lacking. We report a child with IgAV associated with clinical features of hypertension, nephrotic range proteinuria, acute kidney injury, and low serum C3, with histopathologic findings on renal biopsy of membranoproliferative glomerulonephritis with C3 and IgA co-dominance, and extensive complement derangements. Read More

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Case report of sotalol Induced IgA Vasculitis.

Curr Rheumatol Rev 2022 Jun 23. Epub 2022 Jun 23.

Internal Medicine Department, Amita Health St Joseph Hospital, Chicago, Illinois, USA.

Background IgA vasculitis is the most common form of systemic vasculitis in children but can occur in adults. Inciting antigens include infections, drugs, foods, insect bites, and immunizations. Antibiotics and tumor necrosis factor (TNF) alpha inhibitors are the most common class of drugs that cause IgA vasculitis. Read More

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Massive Intestinal Bleeding in an Adult with IgA Vasculitis Treated with Intravenous Immunoglobulin.

Case Rep Rheumatol 2022 14;2022:9694911. Epub 2022 Jun 14.

Department of Medicine, Hadassah Medical Center, The Faculty of Medicine, Hebrew University, Jerusalem, Israel.

We report the case of a 29-year-old adult presenting with severe IgA vasculitis, with cutaneous, urologic, and renal manifestations. The late appearance of severe gastrointestinal bleeding dominated the clinical picture, necessitating the administration of tens of units of packed cells and the augmentation of the immunosuppressive protocol. It was not until therapy with intravenous immunoglobulin (IVIG) was introduced that the massive bleeding was controlled. Read More

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Sudden Onset of IgA Vasculitis Affecting Vital Organs in Adult Patients following SARS-CoV-2 Vaccines.

Vaccines (Basel) 2022 Jun 9;10(6). Epub 2022 Jun 9.

Division of Rheumatology, Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju City 54907, Korea.

IgA vasculitis is an immune complex-mediated small-vessel vasculitis that mainly occurs in children and is characterized by palpable purpura, arthralgia, abdominal pain, and glomerulonephritis. We report three cases of new-onset IgA vasculitis involving major organs in adult patients after they received either the ChAdOx1 viral vector (Oxford/AstraZeneca) vaccine or the messenger RNA-1273 (Moderna) vaccine. These cases suggest that COVID-19 vaccines have the potential to trigger IgA vasculitis and indicate that physicians need to monitor for this possible complication. Read More

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Gut Microbiota Dysbiosis in Childhood Vasculitis: A Perspective Comparative Pilot Study.

J Pers Med 2022 Jun 15;12(6). Epub 2022 Jun 15.

Pediatric Emergency Unit, Department of Medical and Surgical Sciences, IRCCS Azienda Ospedaliero-Universitaria, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.

Kawasaki disease (KD) and Henoch-Schönlein purpura (HSP) are the most frequent vasculitis in childhood. For both, a multifactorial mechanism has been hypothesised, with an abnormal immune response in genetically predisposed children. Gut microbiota (GM) alterations might trigger the hyperimmune reaction. Read More

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Blood routine examination: a simple way for differential diagnosis of immunoglobulin A vasculitis with abdominal involvement and appendicitis in children.

Updates Surg 2022 Jun 23. Epub 2022 Jun 23.

Gastrointestinal Lab, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, 3333 Bin Sheng Road, Hangzhou, 310052, Zhejiang, People's Republic of China.

To explore the value of blood routine examination indexes in the differential diagnosis of immunoglobulin A vasculitis (IgAV) with abdominal involvement and appendicitis in children. Forty-seven patients with IgAV and abdominal involvement, 95 cases with appendicitis, and 48 healthy children were enrolled in this study. Demographic and laboratory data were retrospectively recorded from medical files. Read More

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Long-term Results in Children with Henoch-Schönlein Nephritis.

Medeni Med J 2022 Jun;37(2):159-164

Istanbul Medeniyet University Faculty of Medicine; Istanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Clinic of Pediatric Nephrology, Istanbul, Turkey.

Objective: Henoch-Schönlein purpura (HSP) is a small vessel vasculitis and palpable purpura, with arthritis, gastrointestinal as abdominal pain, and renal involvement as typical clinical findings. The most important prognostic factor for HSP vasculitis is renal involvement. This study aimed to investigate the relationship between clinical, laboratory, and histopathologic findings of children with HSP nephritis with long-term renal prognosis. Read More

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Development and Validation of a Differential Diagnosis Model for Acute Appendicitis and Henoch-Schonlein Purpura in Children.

Pediatr Allergy Immunol Pulmonol 2022 Jun;35(2):86-94

Department of General Surgery, Affiliated Children's Hospital of Nanchang University, Nanchang, China.

To study and develop a predictive model for the differential diagnosis of acute appendicitis (AA) and Henoch-Schonlein purpura (HSP) in children and to validate the model internally and externally. The complete data of AA and HSP cases were retrospectively analyzed and divided into internal and external verification groups. SPSS software was used for single-factor analysis and screening of independent variables, and R software was used for the development and verification of the diagnostic model. Read More

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Navigating the initial diagnosis and management of adult IgA vasculitis: A review.

JAAD Int 2022 Sep 13;8:71-78. Epub 2022 Jun 13.

Division of Dermatology, University of Arizona, Tucson, Arizona.

Background: IgA vasculitis in adults has not been thoroughly studied. This has left a practice gap related to the management and follow-up of a population that is at an increased risk of comorbidities and potentially poor outcomes. For this reason, it is important to synthesize evidence from the current literature because this can help direct the movement for more robust studies to clarify best practice recommendations. Read More

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September 2022

IgA vasculitis with underlying monoclonal IgA gammopathy: innovative therapeutic approach targeting plasma cells. A case series.

Clin Rheumatol 2022 Jun 17. Epub 2022 Jun 17.

Department of Internal Medicine and Clinical Immunology, CHRU Tours, Tours, France.

Objective: There is currently no evidence of the possible benefit of plasma cell-targeting therapies (PCTT) in immunoglobulin A (IgA) monoclonal gammopathy (MG) associated with IgA vasculitis (IgAV). We report the outcome of different PCTT regimens in a cohort of MG-IgAV.

Methods: We used a French network to retrospectively describe the outcome of MG-IgAV patients treated with PCTT. Read More

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COVID-19 associated pediatric vasculitis: A systematic review and detailed analysis of the pathogenesis.

Semin Arthritis Rheum 2022 Jun 9;55:152047. Epub 2022 Jun 9.

Hacettepe University Faculty of Medicine, Department of Pediatrics, Division of Rheumatology, Ankara, Turkey.

Objectives: Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2, has opened a new era in the practice of pediatric rheumatology since it has been associated with inflammatory complications such as vasculitis and arthritis. In this review, we aimed to present a detailed analysis of COVID-19 associated pediatric vasculitis.

Methods: A systematic review of the English literature was performed through Pubmed/MEDLINE and Scopus up to January 1st, 2022. Read More

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Clinical relevance of glomerular C4d deposition in children with early IgA nephropathy or Henoch-Schönlein purpura nephropathy.

Pediatr Nephrol 2022 Jun 13. Epub 2022 Jun 13.

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, 28th Fuxing Road, Beijing, 100045, China.

Background: Both IgA nephropathy (IgAN) and Henoch-Schönlein purpura nephropathy (HSPN) are characterized by glomerular mesangial IgA deposition. Several large studies on adults have suggested that glomerular C4d deposition has prognostic value in IgAN. However, there are few relevant studies on the clinical value of C4d deposition in children with IgAN or HSPN. Read More

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Contrast-enhanced ultrasonography for assessing histopathology in pediatric immunoglobulin A nephropathy and Henoch-Schönlein purpura nephritis.

Pediatr Radiol 2022 Jun 13. Epub 2022 Jun 13.

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China.

Background: Glomerular disease, including immunoglobulin A nephropathy (IgAN) and Henoch-Schönlein purpura nephritis, is one of the most common kidney diseases in children. The diagnosis of these diseases depends on pathological biopsy, although this procedure is seriously limited by its invasive and high-risk nature.

Objective: To investigate the potential of contrast-enhanced ultrasonography (CEUS) for evaluating the histopathological severity of IgAN and Henoch-Schönlein purpura nephritis (HSPN). Read More

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A Cross-Sectional Study to Correlate Serum Complement C3 and C4 Levels With Clinical and Pathological Severity in Cutaneous Small-Vessel Vasculitis.

Cureus 2022 May 9;14(5):e24845. Epub 2022 May 9.

Community Medicine, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar, IND.

Introduction The role of serum C3 and C4 levels as a marker of disease activity in cutaneous small-vessel vasculitis (CSVV) has been sparsely studied, especially in India. The primary objective was to determine the correlation between clinico-histopathological severity and serum C3 and C4 levels in CSVV. The secondary objective was to determine the association between direct immunofluorescence (DIF) findings and serum C3 and C4 levels and clinico-histopathological findings. Read More

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Vasculitis flare after COVID-19: report of two cases in patients with preexistent controlled IgA vasculitis and review of the literature.

Rheumatol Int 2022 Jun 13. Epub 2022 Jun 13.

Rheumatology Unit, Hospital Universitario de La Princesa, IIS-Princesa, Diego de León 62, 28006, Madrid, Spain.

COVID-19 has been related to several autoimmune diseases, triggering the appearance of autoantibodies and endothelial dysfunction. Current evidence has drawn attention to vasculitis-like phenomena and leukocytoclastic vasculitis in some COVID-19 patients. Moreover, it has been hypothesized that COVID-19 could induce flares of preexisting autoimmune disorders. Read More

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COVID-19 and New Onset IgA Vasculitis: A Systematic Review of Case Reports.

J Emerg Nurs 2022 May 13. Epub 2022 May 13.

Introduction: Immunoglobulin A vasculitis is historically more commonly found in children after certain viral infections such as Epstein-Barr, varicella virus, and parvovirus B19. COVID-19 has not been formally established in literature as a trigger for immunoglobulin A vasculitis. However, a main pathogenetic mechanism of COVID-19 is vascular damage, which makes it likely that vasculitis associated with COVID-19 (ie, COVID-19-mediated immunoglobulin A vasculitis) could be biologically plausible, with serious implications, especially for adults. Read More

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A Case of Leukocytoclastic Vasculitis Following SARS-COV-2 Vaccination.

J Emerg Med 2021 Oct 23. Epub 2021 Oct 23.

Harvard Medical School, Boston, Massachusetts; Brigham and Women's Hospital, Boston, Massachusetts.

Background: Although vaccination against coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been proven generally safe, rare but potentially serious adverse reactions do occur. Leukocytoclastic vasculitis (LCV) is a small-vessel vasculitis that has been associated with other immunizations, but, to our knowledge, has not been previously reported in association with vaccines directed against SARS-CoV-2.

Case Report: We report the case of a 22-year-old man with no known past medical history who presented to the Emergency Department with 2 days of migratory arthritis in his ankles and palpable purpura on his bilateral lower extremities, occurring 10 days after receiving the Johnson & Johnson SARS-CoV-2 vaccine. Read More

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October 2021

IgA Vasculitis Involving Both the Upper and Lower Digestive Tracts.

J Gastrointest Surg 2022 Jun 8. Epub 2022 Jun 8.

The First College of Clinical Medical Science, China Three Gorges University, Yichang, China.

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IgA vasculitis with severe renal manifestation.

BMJ Case Rep 2022 Jun 7;15(6). Epub 2022 Jun 7.

Internal Medicine, Hospital Beatriz Angelo, Loures, Lisboa, Portugal.

IgA vasculitis is a rare systemic vasculitis in adults, frequently more severe than in paediatric age. It manifests with cutaneous, articular, gastrointestinal and renal involvement.We present a case of a man in his 40s diagnosed with IgA vasculitis with cutaneous, joint, gastrointestinal and renal disease. Read More

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Rapidly progressive glomerulonephritis in a patient with angioimmunoblastic T-cell lymphoma: a rare autopsy case showing IgA vasculitis and cylinder-like deposits.

Med Mol Morphol 2022 Jun 3. Epub 2022 Jun 3.

Department of Pathology, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.

Angioimmunoblastic T-cell lymphoma (AITL), a hematological malignancy, originates from follicular helper T cells. The primary site of AITL is the lymph nodes, but extranodal presentation is frequent in patients with advanced stages. Here, we report a rare case of a patient with AITL presenting with rapidly progressive glomerulonephritis (RPGN). Read More

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Changes in the spectrum of kidney diseases: a survey of 2803 patients from 2010 to 2018 at a single center in southeastern China.

Ren Fail 2022 Dec;44(1):987-993

Department of Nephrology, The First Affiliated Hospital of Nan Chang University, Nanchang, China.

Primary glomerular disease was the leading cause of chronic kidney disease (CKD) in China; however, changes in the economy and environment introduce variations in the spectrum of kidney diseases. This study aimed to analyze renal biopsy data to inform disease prevention and public health interventions. In this retrospective cohort study, data from 2,803 consecutive renal biopsies conducted at our center between January 2010 and December 2018 were analyzed. Read More

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December 2022

Lumbar swelling and migrating edema in 3- and 4-year-old boys.

SAGE Open Med Case Rep 2022 25;10:2050313X221102112. Epub 2022 May 25.

Department of Pediatric and Public Health Sciences, Regina Margherita Children's Hospital Turin and University of Torino, Turin, Italy.

Henoch-Schönlein purpura is the most common systemic vasculitis in children, characterized by IgA deposits in small vessels. The etiology is unknown, but Henoch-Schönlein purpura typically follows an upper respiratory infection, or less frequently other infective or chemical triggers. The classic tetrad of symptoms includes palpable purpura (mandatory criterion), arthralgias, abdominal pain, and renal involvement. Read More

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Construction of Prediction Model of Renal Damage in Children with Henoch-Schönlein Purpura Based on Machine Learning.

Comput Math Methods Med 2022 23;2022:6991218. Epub 2022 May 23.

School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.

Objective: The children with Henoch-Schönlein purpura (HSP) may suffer from renal insufficiency, which seriously affects the life and health of the children. This study aims to construct a prediction model of Henoch-Schönlein purpura nephritis (HSPN).

Methods: A total of 240 children with HSP treated in dermatology and pediatrics in our hospital were selected. Read More

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A Case of Endothelial Damage-dominant Nephritis Related to IgA Vasculitis after 11 Years' Use of Infliximab for Rheumatoid Arthritis.

Intern Med 2022 May 31. Epub 2022 May 31.

Department of Nephrology and Rheumatology, Toranomon Hospital Kajigaya, Japan.

A 43-year-old Japanese woman with rheumatoid arthritis treated by infliximab and methotrexate for 11 years was admitted for proteinuria and purpura. A kidney biopsy revealed endothelial damage-dominant nephritis with IgA deposition. Infliximab and methotrexate were discontinued, and tocilizumab was started; however, proteinuria persisted. Read More

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Comparison of statistical analysis using the random-effects and inverse variance heterogeneity models for a meta-analysis.

Wei Fu Qin Wang

Int Immunopharmacol 2022 Jul 27;108:108884. Epub 2022 May 27.

Sichuan Treatment Center for Gynaecologic and Breast Diseases (Gynecology), The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, PR China. Electronic address:

In our previous meta-analysis of the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in Henoch-Schonlein purpura (W. Fu, et al., Int. Read More

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