5,260 results match your criteria Henoch-Schonlein Purpura


Henoch-schonlein Purpura Nephritis with Renal Interstitial Lesions.

Open Med (Wars) 2018 27;13:597-604. Epub 2018 Nov 27.

Institute of Pathology, Basic Medical College of Lanzhou University, Lanzhou 730000, Gansu Province, China.

Objective: To investigate the clinical pathology and prognosis & outcome of Henoch-Schonlein purpura nephritis (HSPN) with renal interstitial lesions.

Methods: All 148 patients were analyzed for clinical, renal pathological, and prognostic features. Patients with no, mild, and moderate- severe renal tubulo-interstitial lesions were included in group A, B and C, respectively. Read More

View Article
November 2018

[Effect of miR-21 on the expression of interleukin-10 in B cell of patients with Henoch-Schonlein purpura].

Zhonghua Er Ke Za Zhi 2018 Dec;56(12):939-944

Rheumatology & Immunology Department of Shenzhen Children's Hospital, Shenzhen 518038, China.

To investigate the effect of microRNAs (miR)-21 on the expression of interleukin (IL)-10 in B cell of patients with Henoch-Schonlein purpura (HSP). From March 2016 to January 2017, twenty-four children with HSP hospitalized in rheumatology and immunology department of Shenzhen Children's Hospital were enrolled into the study, including 12 males and 12 females. Patients were divided into purpura nephritis group (HSPN, 14 cases) and non-nephritis group (NHSPN, 10 cases). Read More

View Article
December 2018
1 Read

MEFV gene variants in children with Henoch-Schönlein Purpura and association with clinical manifestations: a single center Mediterranean experience.

Postgrad Med 2018 Dec 4. Epub 2018 Dec 4.

a Department of Pediatric Rheumatology , Cukurova University Faculty of Medicine , Adana , Turkey.

Objectives: Henoch Schönlein Purpura (HSP) is characterized by non-thrombocytopenic palpable purpura, abdominal pain and arthralgia/arthritis. We aimed to describe the clinical presentations of children with HSP in a single center and compare the prevalence of each manifestations between patients with MEFV variants, particularly in exon 10 and those without.

Methods: This cohort retrospectively included 144 HSP (59 females, 85 males) patients without FMF symptoms and followed for at least 6 months. Read More

View Article
December 2018

Atypical purpura location in a pediatric patient with Henoch-Schönlein purpura: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13294

Department of Laboratory, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Rationale: The presence of purpura is a compulsory criteria for the diagnosis of Henoch-Schönlein purpura (HSP). Typical purpura of HSP is distributed symmetrically over the extensor surfaces of the lower limbs, buttocks, and forearms with the occasional involvement of trunk and face in children. It occurs only involving the bottom of the feet has never been reported. Read More

View Article
November 2018
3 Reads

Features distinguishing juvenile idiopathic arthritis among children with musculoskeletal complaints.

World J Pediatr 2018 Nov 29. Epub 2018 Nov 29.

Division of Rheumatology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.

Background: Musculoskeletal (MSK) complaints in children vary, ranging from benign, self-limited conditions to serious disorders. Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease, initially presenting with MSK complaints. Delayed diagnosis and appropriate treatment have an enormous impact on the long-term outcomes and the level of disability. Read More

View Article
November 2018

Cardiovascular, thromboembolic and renal outcomes in IgA vasculitis (Henoch-Schönlein purpura): a retrospective cohort study using routinely collected primary care data.

Ann Rheum Dis 2018 Nov 28. Epub 2018 Nov 28.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK.

Background: IgA vasculitis (IgAV, Henoch-Schönlein purpura) is a small-vessel vasculitis most common in children but also occurring in adults. Case series have suggested that IgAV may be associated with cardiovascular disease and venous thromboembolism, but this has not been evaluated in population-based studies. Renal disease and hypertension are possible complications of the disease with unknown incidence. Read More

View Article
November 2018
1 Read

Intussusception as the main manifestation of Schönlein-Henoch purpura in an adult patient.

Gastroenterol Hepatol 2018 Nov 24. Epub 2018 Nov 24.

Servicio de Medicina Interna, Hospital Universitari del Sagrat Cor, Barcelona, España.

View Article
November 2018

Rare and striking complication of Henoch-Schönlein purpura.

Arch Dis Child 2018 Nov 23. Epub 2018 Nov 23.

Department of Pediatrics, University Hospitals Geneva, Geneva, Switzerland.

View Article
November 2018

Significance of histological crescent formation in patients with IgA vasculitis (Henoch-Schönlein purpura)-related nephritis: a cohort in the adult Chinese population.

BMC Nephrol 2018 Nov 22;19(1):334. Epub 2018 Nov 22.

National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, People's Republic of China.

Background: IgA vasculitis (IgAV, formerly Henoch-Schönlein purpura) is a type of systemic vasculitis. This study aimed to explore the clinicopathological features, treatment and renal outcomes of adult IgAV-related nephritis (Henoch-Schönlein purpura nephritis) patients with different degrees of crescent formation.

Methods: Adult patients with biopsy-proven IgAV-related nephritis in Nanjing Jinling Hospital were enrolled and divided into three groups as follows: control (no crescents, n = 257), group 1 (crescents < 25%, n = 381), and group 2 (crescents ≥25%, n = 60). Read More

View Article
November 2018
1 Read
1.520 Impact Factor

Cord-derived mesenchymal stem cells therapy for liver cirrhosis in children with refractory Henoch-Schonlein purpura: A case report.

Medicine (Baltimore) 2018 Nov;97(47):e13287

Department of Pediatrics, Shandong Provincial Qianfoshan Hospital of Shandong University, Jinan, China.

Rationale: To explore the curative effect of human umbilical cord-derived mesenchymal stem cell (ucMSC) therapy for patients with liver cirrhosis complicated with immune thrombocytopenia and refractory Henoch-Schonlein purpura (HSP).

Patient Concerns: A 12-year-old boy presented to our hospital with an 11-month history of purpura on the skin of both lower limbs accompanied by thrombocytopenia. The patient had a history of repeated swelling and painful dorsum pedis, followed by skin redness. Read More

View Article
November 2018
6 Reads

Expression of DENDRIN in several glomerular diseases and correlation to pathological parameters and renal failure - preliminary study.

Diagn Pathol 2018 Nov 20;13(1):90. Epub 2018 Nov 20.

Department of Pathology, Forensic medicine and Cytology, University Hospital Centre Split, Split, Croatia.

Background: In glomerular injury dendrin translocates from the slit diaphragm to the podocyte nucleus, inducing apoptosis. We analyzed dendrin expression in IgA glomerulonephritis and Henoch Schönlein purpura (IgAN/HSP) versus in podocytopathies minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS), and compared it to pathohistological findings and renal function at the time of biopsy and the last follow-up.

Methods: Twenty males and 13 females with median of age 35 years (min-max: 3-76) who underwent percutaneous renal biopsy and had diagnosis of glomerular disease (GD) were included in this retrospective study. Read More

View Article
November 2018
21 Reads

Immunoglobulin A Nephropathy and Immunoglobulin A Vasculitis.

Pediatr Clin North Am 2019 Feb;66(1):101-110

Department of Pediatrics, Medical University of South Carolina, 96 Jonathan Lucas Street, 428 CSB, MSC 608, Charleston, SC 29425, USA. Electronic address:

Henoch-Schönlein purpura nephritis and immunoglobulin A nephropathy are common glomerulopathies in the pediatric population that deserve special attention. In some cases the primary care provider can follow the patient but others need more intensive management. Delaying this treatment can lead to worse morbidity. Read More

View Article
February 2019
1 Read

Recurrent Henoch Schönlein purpura without renal involvement successfully treated with methotrexate.

Scott Med J 2018 Nov 19:36933018809816. Epub 2018 Nov 19.

5 Professor, Department of Pediatric Rheumatology, Cukurova University Faculty of Medicine, Turkey.

Introduction: Henoch Schönlein purpura is characterised by palpable purpura, abdominal pain, arthritis/arthralgia, often with a self-limiting course. Herein, we report a patient with recurrent Henoch Schönlein purpura and severe gastrointestinal involvement, successfully treated with methotrexate.

Case Presentation: A 12-year-old boy was admitted to our department with palpable purpura, abdominal pain and arthralgia. Read More

View Article
November 2018
2 Reads

Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study.

Kidney Int Rep 2018 Nov 3;3(6):1373-1384. Epub 2018 Aug 3.

Department of Medicine, Division of Nephrology, Columbia University College of Physicians and Surgeons, New York, New York, USA.

Introduction: The Cure Glomerulonephropathy Network (CureGN) is a 66-center longitudinal observational study of patients with biopsy-confirmed minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, or IgA nephropathy (IgAN), including IgA vasculitis (IgAV). This study describes the clinical characteristics and treatment patterns in the IgA cohort, including comparisons between IgAN versus IgAV and adult versus pediatric patients.

Methods: Patients with a diagnostic kidney biopsy within 5 years of screening were eligible to join CureGN. Read More

View Article
November 2018
6 Reads

Rituximab treatment for chronic steroid-dependent Henoch-Schonlein purpura: 8 cases and a review of the literature.

Pediatr Rheumatol Online J 2018 Nov 14;16(1):71. Epub 2018 Nov 14.

Department of Pediatrics, Division of Rheumatology, University of Alabama at Birmingham, 1600 7th Ave S, CPPN G10, Birmingham, AL, 35233, USA.

Background: Henoch-Schonlein purpura (HSP) is a small vessel vasculitis that is characterized by non-thrombocytopenic purpura, abdominal pain, arthritis, and glomerulonephritis. Typically, HSP is self-limited requiring only supportive care, but more severe cases may require corticosteroid (CS) treatment. Rarely, a subset of these patients has persistent rash, arthritis, abdominal involvement, or renal disease despite treatment with CS, or has disease recurrence on CS tapering. Read More

View Article
November 2018
9 Reads

CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease.

Am J Kidney Dis 2018 Nov 9. Epub 2018 Nov 9.

Center for Translational Science, Children's National Health System, Washington, DC.

Rationale & Objectives: Glomerular diseases, including minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and immunoglobulin A (IgA) nephropathy, share clinical presentations, yet result from multiple biological mechanisms. Challenges to identifying underlying mechanisms, biomarkers, and new therapies include the rarity of each diagnosis and slow progression, often requiring decades to measure the effectiveness of interventions to prevent end-stage kidney disease (ESKD) or death.

Study Design: Multicenter prospective cohort study. Read More

View Article
November 2018
6 Reads

Steroid- and immunosuppressant-based protocol of Henoch-Schönlein purpura nephritis without angiotensin inhibitors in the acute phase: case series with correlation to histology.

Minerva Pediatr 2018 Nov 7. Epub 2018 Nov 7.

Ichinomiya Medical Treatment & Habilitation Center, Ichinomiya-city, Aichi, Japan -

Background: The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines suggest initially using angiotensin-converting-enzyme inhibitors (ACE-Is) and/or angiotensin receptor blockers (ARBs) to treat Henoch-Schönlein purpura nephritis (HSPN). However, these guidelines might overlook the potential benefits of aggressive therapy. Therefore, we evaluated the efficacy of an HSPN protocol that primarily uses steroids and immunosuppressants, without ACE-Is or ARBs. Read More

View Article
November 2018
10 Reads

Correlation between endocapillary proliferative and nephrotic-range proteinuria in children with Henoch-Schönlein purpura nephritis.

Pediatr Nephrol 2018 Nov 10. Epub 2018 Nov 10.

Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA.

Background: The endocapillary proliferative (EP) lesion is not included in the International Study of Kidney Disease in Children (ISKDC) pathological classification of Henoch-Schönlein purpura nephritis (HSPN). The main objective of the study was to determine the pathological importance of EP in the development of proteinuria in children with Henoch-Schönlein purpura nephritis (HSPN).

Methods: The pathological features of 148 HSPN children with nephrotic-range proteinuria were investigated retrospectively. Read More

View Article
November 2018
7 Reads
2.860 Impact Factor

Acute renal insufficiency and pancreatitis in a child with atypical Henoch-Schönlein purpura: efficacy of a single dose of cyclophosphamide.

J Int Med Res 2018 Nov 5:300060518800864. Epub 2018 Nov 5.

1 University Department Pro.Sa.M.I. "G. D'Alessandro", University of Palermo, Palermo, Italy.

A 9-year-old boy with petechiae on the legs and abdominal pain was unsuccessfully treated with steroids. He was admitted to our hospital for the onset of fever, ecchymosis, and arthralgia. Skin lesions suggested vasculitis, but they were not typical of Henoch-Schönlein purpura. Read More

View Article
November 2018
5 Reads

A 19-year old man with IgA vasculitis after vaccination.

Braz J Infect Dis 2018 Oct 30. Epub 2018 Oct 30.

UTHealth - McGovern Medical School, Division of Infectious Diseases, Department of Internal Medicine, Houston, TX, United States; UTHealth - McGovern Medical School, Center for Antimicrobial Resistance and Microbial Genomics (CARMiG) and Division of Infectious Diseases, Houston, TXs, United States; UTHealth - School of Public Health, Center for Infectious Diseases, Houston, TX, United States; Universidad El Bosque, Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial Genomics, Bogota, Colombia. Electronic address:

A 19-year-old patient who mistakenly received two doses of influenza vaccine 10 days before presentation, was admitted with malaise, weakness, and a purpuric non-blanching rash most prominent on the ankles followed by abdominal pain and hematochezia 72h later. The diagnosis of influenza vaccine-related Henoch-Schonlein vasculitis was made. This complication, although rare, is the most common vasculitis related to immunization. Read More

View Article
October 2018
13 Reads

Clinical significance of serum and mesangial galactose-deficient IgA1 in patients with IgA nephropathy.

PLoS One 2018 2;13(11):e0206865. Epub 2018 Nov 2.

Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.

Introduction: Galactose-deficient IgA1 (Gd-IgA1) is a critical pathogenic factor for IgA nephropathy (IgAN), but its value as a disease-specific biomarker remains controversial. We aimed to clarify the clinical significance of Gd-IgA1 in patients with IgAN.

Methods: We retrospectively reviewed 111 patients who were diagnosed with IgAN based on the findings of renal biopsies (RB) at Showa University Hospital since 2007. Read More

View Article
November 2018
5 Reads

[Expression and significance of endothelial microparticles in children with Henoch-Schönlein purpura].

Zhongguo Dang Dai Er Ke Za Zhi 2018 Oct;20(10):831-834

Children's Hospital of Zhengzhou University/Children's Hospital of Henan Province/Zhengzhou Children's Hospital/Zhengzhou Children's Critical Medical Key Laboratory, Zhengzhou 450000, China.

Objective: To study the expression and significance of endothelial microparticles (EMPs) in children with Henoch-Schönlein purpura (HSP).

Methods: A total of 100 previously untreated children with HSP were classified to Henoch-Schönlein purpura nephritis (HSPN) group (n=40) and non-nephritis group (n=60). Thirty healthy children who underwent physical examination were enrolled as control group. Read More

View Article
October 2018

[Vasculitides and eosinophilic pulmonary diseases].

Z Rheumatol 2018 Dec;77(10):907-922

Abt. für Rheumatologie, Immunologie und Rehabilitation, Kantonsspital St. Gallen, St. Gallen, Schweiz.

Eosinophilic granulocytes form peripheral effector cells controlled by Th2 lymphocytes, which cause local cell, tissue, and functional disorders of infiltrated organs via the release of cytotoxic basic proteins and oxygen radicals. Diseases associated with eosinophilia include systemic and organ-related forms. The lungs are involved in eosinophilic granulomatosis with polyangiitis (EGPA, formerly known as Churg-Strauss syndrome), acute and chronic eosinophilic pneumonia, as well as in an organ manifestation in hypereosinophilic syndrome and certain parasitic diseases. Read More

View Article
December 2018
8 Reads

Oral microbiota dysbiosis and its association with Henoch-Schönlein Purpura in children.

Int Immunopharmacol 2018 Dec 17;65:295-302. Epub 2018 Oct 17.

Shandong Children's Microbiome Center, Qilu Children's Hospital of Shandong University, Jinan 250022, China; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Chemistry and Environment, Beihang University, Beijing 100191, China; Qingdao Human Microbiome Center, The Affiliated Central Hospital of Qingdao University, Qingdao 266042, China. Electronic address:

Background: The pathogenesis of microbes in allergic diseases has been demonstrated and our previous research indicates that microbiota causing gut disorders in children is associated with Henoch-Schönlein Purpura. However, the role of oral microbiota in Henoch-Schönlein Purpura remains unknown.

Method: A total of 164 children were enrolled, of which 98 were patients with HSP and 66 were healthy children. Read More

View Article
December 2018
6 Reads
2.470 Impact Factor

Adult Onset Henoch-Schonlein Purpura associated with a Metastatic Malignancy of Unknown Primary Origin.

Hawaii J Med Public Health 2018 Oct;77(10):243-245

University of Hawai'i Internal Medicine Residency, Honolulu, HI (TP).

The cause of Henoch-Schonlein purpura, or IgA vasculitis, is largely unknown. It has been associated with infections, other rheumatologic triggers, and adverse drug reactions. Rarely, adult Henoch-Schonlein purpura is also associated with solid-tumor malignancies. Read More

View Article
October 2018
5 Reads

Magnetic-Guided Capsule Endoscopy in the Diagnosis of Gastrointestinal Diseases in Minors.

Gastroenterol Res Pract 2018 18;2018:4248792. Epub 2018 Sep 18.

Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 197 Second Ruijin Road, Shanghai 200025, China.

Objective: This study aimed at investigating the clinical value of magnetic-guided capsule endoscopy (MGCE) in the diagnosis of gastrointestinal diseases in minors.

Methods: Eighty-four minor patients hospitalized in the pediatric department at Ruijin Hospital between June 2015 and January 2018 were enrolled for this study. Following bowel preparation, all patients underwent MGCE. Read More

View Article
September 2018
7 Reads

[Role of Th17 Cells, Interleukin-17 and Matrix Metalloproteinase-13 in Pathogenesis of Henoch-Schonlein Purpura].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Oct;26(5):1502-1506

Department of Hematology, Chaohu Hospital of Anhui Medical University, Chaohu 238001, Anhui Province, China.E-mail: xhl1999cn

Objective: To explore the immunopathogenesis of Henoch-Schonlein purpara (HSP) by detecting the levels of Th17 cells, IL-17 and matrix metallo proteinase-13 (MMP-13) in peripheral blood and the expression of IL-17 in skin lesions at acate phase of HSP.

Methods: Th17 cell ratio in peripheral blood of HSP group and healthy control group was defected by flow cytometry, the plasma levels of IL-17 and MMP-13 in HSP group and healthy control group were defected by ELISA, and expression level of IL-17 in skin lesion of HSP group and skin tissue of healthy control group was deternined by: immunohistochemistry method.

Results: the ratio of Th17 cells in periphral blood of HSP group (1. Read More

View Article
October 2018

Defining significant childhood illness and injury in the Emergency Department: a consensus of UK and Ireland expert opinion.

Emerg Med J 2018 Nov 3;35(11):685-690. Epub 2018 Oct 3.

Department of Paediatric Emergency Medicine, Imperial College NHS Trust, London, UK.

Background: Clarifying whether paediatric early warning scores (PEWS) accurately predict significant illness is a research priority for UK and Ireland paediatric emergency medicine (EM). However, a standardised list of significant conditions to benchmark these scores does not exist.

Objectives: To establish standardised significant illness endpoints for use in determining the performance accuracy of PEWS and safety systems in emergency departments (ED), using a consensus of expert opinion in the UK and Ireland. Read More

View Article
November 2018
1 Read

Effect of Montmorillonite powder on intestinal mucosal barrier in children with abdominal Henoch-Schonlein purpura: A randomized controlled study.

Medicine (Baltimore) 2018 Sep;97(39):e12577

Open Laboratory, West China Institute for Women's and Children's Health, Chengdu, Sichuan Province, China.

Background: Our previous studies found that intestinal barrier function has been changed in children with abdominal Henoch-Schonlein purpura (HSP). Montmorillonite has been shown to be protective for digestive tract mucosa.

Objective: The present study aimed to investigate whether Montmorillonite powder could improve the intestinal mucosal barrier function in children with abdominal HSP. Read More

View Article
September 2018
5 Reads

Risk factors for renal involvement and severe kidney disease in 2731 Chinese children with Henoch-Schönlein purpura: A retrospective study.

Medicine (Baltimore) 2018 Sep;97(38):e12520

Department of Pediatrics.

To identify the risk factors for developing renal involvement and severe kidney disease in Chinese childhood Henoch-Schönlein purpura (HSP) patients.This was a retrospective study of 2731 children with HSP diagnosed between 2012 and 2015. We analyzed their demographic data, clinical manifestations, and laboratory tests retrospectively. Read More

View Article
September 2018
4 Reads

Posterior reversible encephalopathy syndrome in immunoglobulin A-associated vasculitis.

Neurol Neurochir Pol 2018 Sep - Oct;52(5):634-635. Epub 2018 Sep 5.

University Children's Hospital, Inselspital, and University of Bern, Bern, Switzerland.

View Article
September 2018
2 Reads

Analysis of seasonal tendencies in pediatric Henoch-Schönlein purpura and comparison with outbreak of infectious diseases.

Medicine (Baltimore) 2018 Sep;97(36):e12217

Department of Pediatrics.

Henoch-Schönlein purpura (HSP) is one of the most common vasculitis in children. This study was aimed at identifying seasonal trends and epidemiologic features of pediatric HSP patients through public data to analyze the correlation of HSP and prevalence of a specific respiratory or enteric virus.We extracted information on pediatric HSP patients categorized into 4 age groups and data on 8 respiratory and 4 enteric viruses were extracted from national data. Read More

View Article
September 2018
2 Reads

A case of Henoch-Schonlein Purpura with dilated coronary arteries.

Pediatr Rheumatol Online J 2018 Sep 4;16(1):54. Epub 2018 Sep 4.

Department of Pediatric Rheumatology, Children's Hospital Colorado, 13123 East 16th Avenue, B311, Aurora, CO, 80045, USA.

Background: Henoch-Schonlein Purpura (HSP) is one of the most common vasculitides of childhood, with 10-20 cases per 100,000 children. It frequently occurs following an infectious trigger and involves IgA and C3 deposition in small vessel walls. HSP is characterized by palpable purpura plus IgA deposition on biopsy, arthritis/arthralgia, renal involvement (hematuria and/or proteinuria), and/or abdominal pain. Read More

View Article
September 2018
7 Reads

Ulcerative colitis in an adult patient mimicking Henoch-Schönlein purpura: A case report.

Medicine (Baltimore) 2018 Aug;97(35):e12036

Rationale: Ulcerative colitis (UC) is one of the chronic inflammatory diseases of the intestinal tract. UC being misdiagnosed as Henoch-Schönlein purpura (HSP) in the elderly has seldom been reported about.

Patient Concerns: A 64-year-old man was admitted to the hospital with petechiae and palpable purpura in lower limbs and abdominal pain for about 1 month. Read More

View Article
August 2018
9 Reads

Vasculitis Pathogenesis: Can We Talk About Precision Medicine?

Front Immunol 2018 14;9:1892. Epub 2018 Aug 14.

Division of Rheumatology, Department of Pediatrics, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Turkey.

Precision medicine is designing the medical care by taking into account the individual variability for each person. We have tried to address whether the existing data may guide precision medicine in primary systemic vasculitides (PSV). We have reviewed genome-wide association studies (GWAS) data, lessons from monogenic mimics of these diseases, and biomarker studies in immunoglobulin A vasculitis/Henoch-Schönlein purpura, Kawasaki disease, anti-neutrophil cytoplasmic antibody-associated vasculitis, polyarteritis nodosa (PAN), Takayasu arteritis, and Behçet's disease (BD). Read More

View Article
August 2018
2 Reads

[Gastrointestinal bleeding in a Schönlein-Henoch purpura patient].

Aten Primaria 2018 Oct 25;50(8):509-510. Epub 2018 Aug 25.

Servicio de Aparato Digestivo, Hospital Universitario Central de Asturias, Oviedo, España.

View Article
October 2018

Henoch-Schönlein Purpura Presenting With Subcutaneous Edema: A Case Report and a Proposal to Include Subcutaneous Edema as a Diagnostic Criterion.

J Clin Rheumatol 2018 Aug 23. Epub 2018 Aug 23.

Department of Pediatrics Staten Island University Hospital Northwell Health Staten Island, NY

View Article
August 2018
1 Read

[Vasculitides and eosinophilic pulmonary diseases].

Internist (Berl) 2018 09;59(9):898-910

Abt. für Rheumatologie, Immunologie und Rehabilitation, Kantonsspital St. Gallen, St. Gallen, Schweiz.

Eosinophilic granulocytes form peripheral effector cells controlled by Th2 lymphocytes, which cause local cell, tissue, and functional disorders of infiltrated organs via the release of cytotoxic basic proteins and oxygen radicals. Diseases associated with eosinophilia include systemic and organ-related forms. The lungs are involved in eosinophilic granulomatosis with polyangiitis (EGPA, formerly known as Churg-Strauss syndrome), acute and chronic eosinophilic pneumonia, as well as in an organ manifestation in hypereosinophilic syndrome and certain parasitic diseases. Read More

View Article
September 2018
13 Reads

Serum GDIgA1 levels in children with IgA nephropathy and Henoch-Schönlein nephritis.

Cent Eur J Immunol 2018 30;43(2):162-167. Epub 2018 Jun 30.

Department of Paediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.

Introduction: GDIgA1 (galactose deficient IgA1) plays a significant role in the pathogenesis of IgA nephropathy (IgAN) and Henoch-Schönlein nephritis (HSN).

Aim Of The Study: The aim of this study was to assess the relevance of serum GDIgA1 level as a prognostic marker in children with IgAN and HSN.

Material And Methods: 41 children were included to the study group (15 IgAN, 26 HSN) and 22 to the control group. Read More

View Article
June 2018
3 Reads

Clinical impact of endocapillary proliferation according to the Oxford classification among adults with Henoch-Schönlein purpura nephritis: a multicenter retrospective cohort study.

BMC Nephrol 2018 Aug 17;19(1):208. Epub 2018 Aug 17.

Department of Nephrology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Background: Henoch-Schönlein purpura nephritis (HSPN) is a form of small vessel vasculitis associated with purpura and IgA deposition in the glomeruli. The International Study of Kidney Disease in Children (ISKDC) classification predicts renal prognosis in children with HSPN, but not in adults. Additionally, it is not well known whether the Oxford classification 2016 and/or the Japanese Histologic classification (JHC) are associated with renal outcome. Read More

View Article
August 2018
2 Reads

Significance of glomerular fibrinogen deposition in children with Henoch-Schönlein purpura nephritis.

Ital J Pediatr 2018 Aug 16;44(1):97. Epub 2018 Aug 16.

Department of Pathology, Soochow University Affiliated Children's Hospital, Suzhou, Jiangsu, China.

Background: Henoch-Schönlein purpura nephritis (HSPN) is the most common pediatric secondary glomerular disease. This study aimed to investigate the significance of glomerular fibrinogen (Fib) deposition in children with HSPN.

Methods: Eighty-two patients with HSPN were enrolled retrospectively at the Children's Hospital of Soochow University from January 2015 to March 2017. Read More

View Article
August 2018
8 Reads

[Tripterygium glycosides in treatment of henoch-schonlein purpura nephritis: a systematic review of randomized controlled trials].

Zhongguo Zhong Yao Za Zhi 2018 Jul;43(13):2806-2816

Department of Nephrology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China.

To evaluate the clinical efficacy and safety of tripterygium glycosides (TG) in the treatment of henoch-schonlein purpura nephritis(HSPN). Seven English and Chinese databases (up to Nov. 9, 2017), were searched to collect the RCTs on TG for HSPN. Read More

View Article
July 2018
4 Reads

Clinical and Pathological Characteristics of Elderly Japanese Patients with IgA Vasculitis with Nephritis: A Case Series.

Intern Med 2018 Aug 10. Epub 2018 Aug 10.

Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Japan.

Objective This case series aimed to identify the clinical and pathological characteristics of elderly patients (≥60 years) with biopsy-proven IgA vasculitis with nephritis (IgAVN). Methods The clinical and pathological presentation and treatment outcomes were compared between two groups. Patients Patients with IgAVN who were ≥19 years old at the time of their renal biopsy were divided into elderly (≥60 years) and adult (19-59 years) groups. Read More

View Article
August 2018
2 Reads

Is Henoch-Schönlein purpura a susceptibility factor for functional gastrointestinal disorders in children?

Rheumatol Int 2018 Aug 12. Epub 2018 Aug 12.

Department of Pediatric Rheumatology, Cukurova University Faculty of Medicine, Adana, Turkey.

Henoch-Schönlein purpura (HSP), the most common childhood vasculitis is characterized by non-thrombocytopenic palpable purpura, arthritis/arthralgia, abdominal pain and renal involvement. Functional gastrointestinal disorders (FGIDs) are heterogeneous disease spectrum with unclear etiology and include the most common subtypes: functional dyspepsia, irritable bowel syndrome (IBS), functional abdominal pain and functional constipation. Formerly, FGIDs were known as non-organic disorders; however, recent advances revealed that low-grade inflammation may also play a role. Read More

View Article
August 2018
4 Reads

Adult Henolch-Schonlein purpura: multiorgan failure in the setting of a purpuric rash.

BMJ Case Rep 2018 Aug 9;2018. Epub 2018 Aug 9.

Internal Medicine, University of Tennessee at Chattanooga, College of Health Education and Professional Studies, Chattanooga, Tennessee, USA.

We report a 66-year-old man with a history of congestive heart failure, atrial fibrillation on warfarin therapy and chronic kidney disease that presented with acute dyspnoea. He had multiple palpable purpuric lesions on his bilateral lower extremities. Laboratory findings supported acute anaemia with no obvious bleeding source, supratherapeutic international normalised ratio and acute on chronic kidney injury. Read More

View Article
August 2018
3 Reads

MicroRNA expression in the affected skin of adult patients with IgA vasculitis.

Clin Rheumatol 2018 Aug 6. Epub 2018 Aug 6.

Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

IgA vasculitis (IgAV) represents a common systemic vasculitis in pediatric and adult population. Our current knowledge of disease pathogenesis is still very limited, without information on miRNAs in IgAV. The aim of our study was to determine the expression of five pre-selected miRNAs (miRNA-146a-5p, miRNA-148-3p, miRNA-155-5p, miRNA-223-3p, and let-7b) in the affected skin of adult IgAV patients. Read More

View Article

Antiphospholipid antibodies in adult IgA vasculitis: observational study.

Clin Rheumatol 2018 Aug 2. Epub 2018 Aug 2.

Department of Rheumatology, University Medical Centre Ljubljana, Vodnikova cesta 62, 1000, Ljubljana, Slovenia.

We evaluated the occurrence of antiphospholipid antibodies (aPLs) in acute adult IgA vasculitis (IgAV), and potential correlations with IgAV clinical presentation. We determined lupus anticoagulants (LAs) and IgG, IgM, and IgA isotypes of anticardiolipin antibodies (aCL), antibodies against β2-glycoprotein I (aβ2GPI) and against the phosphatidylserine-prothrombin complex (aPS/PT) in prospectively collected, histologically proven IgAV, diagnosed for the first time between January 2013 and February 2018 at our secondary/tertiary rheumatology center. During the 62 months, we determined aPLs in 125 IgAV patients (56. Read More

View Article

A child with arthritis, skin rash, abdominal pain and nephritis: searching beyond Henoch-Schönlein purpura-Answers.

Pediatr Nephrol 2018 Jul 27. Epub 2018 Jul 27.

Pediatric Multi-disciplinary Clinic, University of Florida, 841 Prudential Drive Suite 1900, Jacksonville, FL, 32207, USA.

View Article
July 2018
2 Reads

A child with arthritis, skin rash, abdominal pain and nephritis: searching beyond Henoch-Schönlein purpura-Questions.

Pediatr Nephrol 2018 Jul 27. Epub 2018 Jul 27.

Pediatric Multi-disciplinary Clinic, University of Florida, 841 Prudential drive Suite 1900, Jacksonville, FL, 32207, USA.

View Article
July 2018
1 Read

Clinicopathological features of pediatric renal biopsies in the plateau regions of China.

J Int Med Res 2018 Nov 20;46(11):4539-4546. Epub 2018 Jul 20.

1 Department of Pediatrics, West China Second University Hospital, Sichuan University, Sichuan Province, China.

Objective: This study aimed to analyze the clinicopathological features of pediatric renal biopsies from plateau regions of China.

Methods: Clinicopathological features of pediatric renal biopsies were compared between plateau and non-plateau regions in patients who were admitted to West China Second University Hospital, Sichuan University between April 2001 and March 2017. Patients were children younger than 18 years. Read More

View Article
November 2018
10 Reads
1.090 Impact Factor