5,414 results match your criteria Henoch-Schonlein Purpura


Adult-onset IgA vasculitis (Henoch-Schönlein): update on therapy.

Presse Med 2020 Jul 6:104035. Epub 2020 Jul 6.

Department of Biochemical, Experimental and Clinical Sciences "Mario Serio", University of Firenze, and Meyer Children's Hospital, Firenze, Italy. Electronic address:

Immunoglobulin A vasculitis (IgAV, formerly Henoch-Schönlein purpura) is a systemic inflammatory disease affecting small vessels. While it is common and usually benign in childhood, in adults it is rarer has a more severe course. Its main manifestations are cutaneous purpura, arthralgias or arthritis, acute enteritis and glomerulonephritis. Read More

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http://dx.doi.org/10.1016/j.lpm.2020.104035DOI Listing

Purpura-free small intestinal IgA vasculitis complicated by cytomegalovirus reactivation.

BMJ Case Rep 2020 Jul 6;13(7). Epub 2020 Jul 6.

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine Hospital, Osaka-Sayama, Osaka, Japan.

IgA vasculitis (Henoch-Schönlein purpura) affects various organs, including the skin, gastrointestinal (GI) tract, joints and kidneys. Its clinical course typically consists of two phases: initial appearance of purpura and delayed onset of arthralgia, GI symptoms and haematuria. We report the case of an adult patient with IgA vasculitis of the small bowel, without skin involvement, complicated by cytomegalovirus (CMV) enteritis following prednisolone administration. Read More

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http://dx.doi.org/10.1136/bcr-2020-235042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342267PMC

Treatment of Henoch-Schönlein purpura using acupuncture: a case report.

Acupunct Med 2020 Jul 5:964528420929350. Epub 2020 Jul 5.

Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

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http://dx.doi.org/10.1177/0964528420929350DOI Listing

Value of electron microscopy in the pathological diagnosis of native kidney biopsies in children.

Pediatr Nephrol 2020 Jul 3. Epub 2020 Jul 3.

Laboratory of Electron Microscopy, Pathological Center, Peking University First Hospital, No. 8. Xishiku Street, Xi Cheng District, Beijing, 100034, China.

Background: Pediatric native kidney diseases are common worldwide. The pathological diagnosis of kidney lesions is crucial for clinical treatment and prognosis. The aim of the current study was therefore to evaluate the value of electron microscopy (EM) to the final diagnosis of native kidney biopsies in children. Read More

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http://dx.doi.org/10.1007/s00467-020-04681-6DOI Listing

Spectrum of biopsy proven renal diseases in Central China: a 10-year retrospective study based on 34,630 cases.

Sci Rep 2020 Jul 3;10(1):10994. Epub 2020 Jul 3.

Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China.

Chronic kidney diseases have become a major issue worldwide. The spectrum of biopsy proven renal diseases differs between locations and changes over time. It is therefore essential to describe the local epidemiological trends and the prevalence of renal biopsy in various regions to shine new light on the pathogenesis of various renal diseases and provide a basis for further hypothesis-driven research. Read More

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http://dx.doi.org/10.1038/s41598-020-67910-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335090PMC

Gastrointestinal involvement in adult immunoglobulin A vasculitis and its management. Comment on Gastrointestinal involvement in adult IgA vasculitis (Henoch-Schönlein purpura): updated picture from a French multicentre and retrospective series of 260 cases.

Rheumatology (Oxford) 2020 Jul 2. Epub 2020 Jul 2.

Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, SloveniaFaculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

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http://dx.doi.org/10.1093/rheumatology/keaa278DOI Listing

Obesity is associated with severe clinical course in children with Henoch-Schonlein purpura.

Pediatr Nephrol 2020 Jun 29. Epub 2020 Jun 29.

Faculty of Medicine, Department of Pediatric Rheumatology, Dokuz Eylul University, Izmir, Turkey.

Background: We aimed to evaluate the role of obesity on the clinical course and response to treatment in patients with Henoch-Schonlein purpura (HSP).

Methods: Data charts of children with HSP followed in a tertiary hospital between 2000 and 2018 were reviewed retrospectively. Persistent purpura was defined as skin involvement persisting for ≥ 30 days. Read More

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http://dx.doi.org/10.1007/s00467-020-04672-7DOI Listing

Procalcitonin and C-reactive Protein Levels as Biomarkers to Determine Gastrointestinal Involvement in Adult Henoch-Schönlein Purpura Patients.

Acta Reumatol Port 2020 Jan-Mar;45(1):34-38

Objective: To investigate the association of procalcitonin (PCT) and C-reactive protein (CRP) levels with gastrointestinal (GI) involvement in adult HSP patients.

Method: A retrospective study using clinical data and serum PCT and CRP levels from 121 adult HSP patients was performed.

Results: The proportion of male HSP patients with GI involvement was significantly higher compared to patients without GI involvement. Read More

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Immunoglobulin A vasculitis presenting as terminal ileitis in late adulthood.

J R Coll Physicians Edinb 2020 Jun;50(2):156-158

Department of Renal Medicine, Norfolk and Norwich University Hospital, Colney Lane, Norwich, NR4 7UY, UK, Email:

Adult-onset immunoglobulin (IgA) vasculitis presenting as terminal ileitis is a rare clinical encounter which can mimic inflammatory bowel disease or infectious gastroenteritis. A high index of clinical suspicion is required to reach the correct diagnosis and to implement the appropriate management plans. Herein, we report a case of an elderly female presenting with a short history of abdominal pain, vomiting, bloody diarrhoea, fatigue and reduced appetite. Read More

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http://dx.doi.org/10.4997/JRCPE.2020.216DOI Listing

Multisystemic manifestations of IgA vasculitis.

Clin Rheumatol 2020 Jun 16. Epub 2020 Jun 16.

Department of Chinese Medicine, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, No. 56 Nanlishi Road, Beijing, 100045, China.

Immunoglobulin A vasculitis (IgAV), also known as Henoch-Schönlein Purpura, is one of the most common kind of systemic vasculitis in children, and due to the involvement of small blood vessels throughout the body, this disease can cause a variety of symptoms in different organs. Our aim was to review the data on various systemic manifestations of IgAV. A research of the literature was performed in PubMed database, utilizing the MeSH terms "IgA vasculitis" and "Henoch Schönlein Purpura". Read More

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http://dx.doi.org/10.1007/s10067-020-05166-5DOI Listing

Henoch-schönlein Purpura (HSP) in a patient on Abemaciclib.

Breast 2020 08 2;52:132-133. Epub 2020 Jun 2.

Department of Medical and Surgical Sciences for Children and Adults, Division of Oncology, University Hospital of Modena, Italy.

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http://dx.doi.org/10.1016/j.breast.2020.05.011DOI Listing

Recurrent Henoch-Schönlein Purpura with bullous rash and pulmonary nodules.

Pediatr Rheumatol Online J 2020 May 24;18(1):40. Epub 2020 May 24.

Department of Pediatrics, Duke University Hospital, 2301 Erwin Rd, Durham, NC, 27705, USA.

Background: Henoch-Schönlein purpura (HSP) is the most common vasculitis of childhood. It has a characteristic rash described as palpable purpura that most frequently affects the distal lower extremities and buttocks. HSP rarely presents with bullous rash nor pulmonary nodules. Read More

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http://dx.doi.org/10.1186/s12969-020-00436-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245848PMC

Rituximab in severe immunoglobulin-A vasculitis (Henoch-Schönlein) with aggressive nephritis.

Clin Exp Rheumatol 2020 Mar-Apr;38 Suppl 124(2):195-200. Epub 2020 May 22.

CMID-Nephrology and Dialysis Unit, Center of Research of Rheumatologic, Nephrologic and Rare Diseases, and Coordinating Centre of the Network for Rare Diseases of Piedmont and Aosta Valley, San Giovanni Bosco Hospital and University of Turin, Italy.

Objectives: Immunoglobulin-A vasculitis (IgAV) is a systemic small-vessel vasculitis in which renal involvement indicates severity of illness, and chronic kidney disease represents the most serious long-term complication. No treatment at present is specifically recommended for IgAV. Recently, rituximab (RTX) has been shown to be effective in case series of adults with IgAV. Read More

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[Expression and significance of follicular helper T cells and galactose-deficient IgA1 in children with Henoch-Schönlein purpura].

Zhongguo Dang Dai Er Ke Za Zhi 2020 May;22(5):473-477

Objective: To study the role of follicular helper T (Tfh) cells and galactose-deficient IgA1 (Gd-IgA1) in the pathogenesis of childhood Henoch-Schönlein purpura (HSP) and the correlation between them.

Methods: A total of 36 children with newly-diagnosed HSP were enrolled. They were divided into two groups: HSP nephritis (HSPN) group with 11 children and non-HSPN group with 25 children according to the presence or absence of HSPN. Read More

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Case of Gut Necrosis in Adult-Onset Immunoglobulin A Vasculitis (Henoch-Schönlein Purpura).

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620925565

Medical College of Georgia at Augusta University, Augusta, GA, USA.

Immunoglobulin A vasculitis (IgAV), formerly known as Henoch-Schönlein purpura, is an immune-mediated small vessel vasculitis characterized by palpable purpura, arthralgia, abdominal pain, and renal disease. It is primarily a childhood disease and usually resolves spontaneously with supportive therapy. Treatment of IgAV in adults is controversial with no clearly established guidelines. Read More

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http://dx.doi.org/10.1177/2324709620925565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243385PMC

Low Back Pain and Swelling as an Atypical Presentation of IgA Vasculitis.

Clin Pract Cases Emerg Med 2020 May 14;4(2):241-243. Epub 2020 Apr 14.

Ohio Valley Medical Center, Department of Emergency Medicine, Wheeling, West Virginia.

Introduction: Immunoglobulin A vasculitis (IgA vasculitis), formerly Henoch-Schonlein purpura, is the most common vasculitis in children.

Case Report: A 6-year-old female presented with low back pain and swelling, difficulty ambulating, and rash two weeks after a respiratory infection. She was approached with a broad differential and ultimately diagnosed with IgA vasculitis. Read More

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http://dx.doi.org/10.5811/cpcem.2019.11.44574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219997PMC

Erythema multiforme in a 14-year-old girl with Henoch-Schönlein purpura and pancolitis: a relationship with mesalazine?

J Dtsch Dermatol Ges 2020 May;18(5):496-498

Institute of Dermatology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

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http://dx.doi.org/10.1111/ddg.14089DOI Listing

The Role of MIF-173G/C Gene Polymorphism in the Susceptibility of Autoimmune Diseases.

Mediators Inflamm 2020 28;2020:7825072. Epub 2020 Apr 28.

Department of Endocrinology and Metabolism, Binzhou Medical University Hospital, 661 Second Huanghe Road, Binzhou 256603, China.

Some certain genetic polymorphisms have been considered to implicate in the pathogenesis and progression of autoimmune diseases and may predispose to an early stage of general autoimmune susceptibility. Recent studies have been conducted to investigate the association between macrophage migration inhibitory factor- (MIF-) 173G/C gene polymorphism and autoimmune diseases; however, the results were not exactly identical. In the present study, a systematic review and meta-analysis of case-control studies was performed to estimate the relationship. Read More

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http://dx.doi.org/10.1155/2020/7825072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204238PMC

Apoptosis inhibitor of macrophage as a biomarker for disease activity in Japanese children with IgA nephropathy and Henoch-Schönlein purpura nephritis.

Pediatr Res 2020 May 14. Epub 2020 May 14.

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

Background: To evaluate the apoptosis inhibitor of macrophage (AIM) deposition patterns on the kidneys of children with IgA nephropathy (IgAN) and Henoch-Schönlein purpura nephritis (HSPN) and to investigate the clinical usefulness of serum and/or urinary AIM levels as biomarkers for the disease activity.

Methods: Immunohistochemical study was performed in the kidneys of 37 patients with IgAN and 10 patients with HSPN. Serum and urinary AIM levels in the patients and 20 healthy controls (HCs) were quantified by enzyme-linked immunosorbent assay. Read More

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http://dx.doi.org/10.1038/s41390-020-0951-1DOI Listing

Activation of Complement System in Henoch-Schönlein Purpura Nephritis.

Fetal Pediatr Pathol 2020 May 13:1-8. Epub 2020 May 13.

Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

We studied the association between Henoch-Schönlein purpura nephritis (HSPN) and complement system activation. We retrospectively reviewed the pathologic findings and medical records of 35 children and 12 adults with HSPN and compared the differences according to C4d positivity in three groups consisting of total 47 patients, 35 pediatric and 12 adult patients, respectively. C4d staining of renal biopsy was additionally performed at the time of diagnosis or retrospectively using archival biopsy material. Read More

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http://dx.doi.org/10.1080/15513815.2020.1761914DOI Listing
May 2020
0.398 Impact Factor

Comparison of clinicopathological features and prognosis between IgA nephropathy and purpura nephritis in adults with diffuse endocapillary proliferation: a single-center cohort study.

Ann Palliat Med 2020 May 26;9(3):795-804. Epub 2020 Apr 26.

Department of Nephrology (Key Laboratory of Management of Kidney Disease in Zhejiang Province), Guangxing Hospital Affiliated to Zhejiang Chinese Medical University (Hangzhou Hospital of Traditional Chinese Medicine), Hangzhou 310007, China.

Background: Clinical manifestations and histological lesions of IgA nephropathy and Henoch-Schönlein purpura nephritis (HSPN) are different, but related, and are also correlated with the renal outcomes. This study aimed to compare the features of immunoglobulin A nephropathy (IgAN) and HSPN in adult patients with diffuse endocapillary proliferation (DEP) lesions aiming to clarify the differences and relationships in the clinicopathological findings and outcome.

Methods: Twelve patients with DEP-IgAN and 10 patients with DEP-HSPN were enrolled. Read More

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http://dx.doi.org/10.21037/apm.2020.04.04DOI Listing

Henoch-Schönlein Purpura in Children: An Updated Review.

Curr Pediatr Rev 2020 May 7. Epub 2020 May 7.

Pediatric Institute, Kuala Lumpur General Hospital, Kuala Lumpur. Malaysia.

Background: Henoch-Schönlein purpura (HSP) is an IgA-mediated systemic small-vessel vasculitis with a predilection for the skin, gastrointestinal tract, joints, and kidneys. It is the most common form of systemic vasculitis in children.

Objective: To familiarize physicians with the etiopathogenesis, etiology, clinical manifestations, evaluation, and management of children with Henoch-Schönlein purpura. Read More

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http://dx.doi.org/10.2174/1573396316666200508104708DOI Listing

IgA vasculitis with nephritis in children.

Adv Clin Exp Med 2020 Apr;29(4):513-519

Chair and Department of Pediatrics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Poland.

Immunoglobulin A vasculitis (IgAV), formerly known as Henoch-Schönlein purpura (HSP), is the most common form of systemic vasculitis in children. Although the first case of IgAV was described more than 200 years ago, its etiology still remains unclear. Nephrological symptoms are observed in 30-50% of children during the course of the disease, and in up to 91% of cases within 6 weeks of the onset of the first symptoms. Read More

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http://dx.doi.org/10.17219/acem/112566DOI Listing

IgA vasculitis and anti-GBM disease: two ends of a spectrum of immune complex vasculitis.

Authors:
Alan D Salama

Rheumatology (Oxford) 2020 May;59(Supplement_3):iii118-iii122

UCL Department of Renal Medicine, Royal Free Hospital, London, UK.

Two immune complex vasculitides, IgA vasculitis (IgAV) and anti-GBM disease, represent polar extremes with regard to our understanding of disease pathogenesis, standardized management protocols and outcomes. This report compares our current approach to these uncommon entities in adults. Both diseases demonstrate degrees of small vessel necrosis and glomerular crescent formation. Read More

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http://dx.doi.org/10.1093/rheumatology/kez540DOI Listing

Childhood vasculitis.

Authors:
Seza Ozen Erdal Sag

Rheumatology (Oxford) 2020 May;59(Supplement_3):iii95-iii100

Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, Turkey.

Vasculitis is a challenging disease for paediatricians. Certain vasculitides are quite common in children whereas others are much rarer compared with adults. The most common vasculitides in childhood are IgA-associated vasculitis (Henoch-Schönlein purpura) and Kawasaki disease, which are usually self-limiting vasculitides although children do develop complications as a result. Read More

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http://dx.doi.org/10.1093/rheumatology/kez599DOI Listing
May 2020
4.475 Impact Factor

Protocol for a randomized multicenter study for isolated skin vasculitis (ARAMIS) comparing the efficacy of three drugs: azathioprine, colchicine, and dapsone.

Trials 2020 Apr 28;21(1):362. Epub 2020 Apr 28.

Divison of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA.

Background: Skin-limited forms of vasculitis, while lacking systemic manifestations, can persist or recur indefinitely, cause pain, itch, or ulceration, and be complicated by infection or scarring. High-quality evidence on how to treat these conditions is lacking. The aim of this comparative effectiveness study is to determine the optimal management of patients with chronic skin-limited vasculitis. Read More

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http://dx.doi.org/10.1186/s13063-020-04285-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189702PMC

Adult-Onset Immunoglobulin A Vasculitis.

ACG Case Rep J 2020 Mar 16;7(3):e00306. Epub 2020 Mar 16.

Flint Gastroenterology Associates, Grand Blanc, MI.

Immunoglobulin A vasculitis (IgAV), formerly Henoch-Schönlein purpura vasculitis, is a vasculitis commonly seen in children and only rarely described in adult patients. IgAV can present as arthralgia, rash, discolored urine, acute kidney injury, and gastrointestinal symptoms. We present a case of a 56-year-old man who presented with 1 month of worsening abdominal pain followed by a bilateral lower extremity rash. Read More

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http://dx.doi.org/10.14309/crj.0000000000000306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162119PMC

A cross-sectional analysis of clinicopathologic similarities and differences between Henoch-Schönlein purpura nephritis and IgA nephropathy.

PLoS One 2020 23;15(4):e0232194. Epub 2020 Apr 23.

Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.

Introduction: Recent studies noted that Henoch-Schönlein purpura nephritis (HSPN) and IgA nephropathy (IgAN) share the feature of galactose-deficient IgA1 (Gd-IgA1)-oriented pathogenesis, although there are distinct clinical differences. We aimed to clarify the clinicopathologic differences between these 2 diseases.

Methods: We cross-sectionally analyzed adult patients with HSPN (n = 24) or IgAN (n = 56) who underwent renal biopsy (RB) between 2008 and 2018 at Showa University Hospital. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232194PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179927PMC

Clostridioides difficile infection in a patient with immunoglobulin A vasculitis: a triggering factor or a rare complication of the disease? A case-based review.

Rheumatol Int 2020 Jun 21;40(6):997-1000. Epub 2020 Apr 21.

Evangelismos General Hospital, 45-47 Ipsilantou Str, Athens, Greece.

IgA vasculitis, formerly known as Henoch-Schonlein purpura (HSP), is the most common form of systemic vasculitis in children and is characterized by inflammation of the small vessels with typical deposition of IgA immune complexes. It is a leukocytoclastic type of vasculitis and is characterized by a tetrad of clinical manifestations: non-thrombocytopenia or coagulopathy-induced palpable purpura, arthritis, or arthralgia, gastrointestinal, and renal involvement. The exact cause of IgA vasculitis is not known yet, although infections, vaccinations and insect bites have been implicated in the appearance of the disease. Read More

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http://dx.doi.org/10.1007/s00296-020-04586-5DOI Listing

A Case of Adult-onset Henoch-Schönlein Purpura Triggered by Fire Ants.

Cureus 2020 Mar 20;12(3):e7341. Epub 2020 Mar 20.

Surgery, Beaumont Hospital, Dearborn, USA.

Adult-onset IgA vasculitis, also known as Henoch-Schönlein purpura (HSP), is a rare disease that often presents with a non-blanchable, purpuric rash and can simultaneously affect the gastrointestinal, renal and musculoskeletal systems. The etiology of HSP is unknown. It can be triggered by any entity that creates an immunological insult, including medications, infections and vaccines. Read More

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http://dx.doi.org/10.7759/cureus.7341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164697PMC

A case of Henoch-Schönlein purpura associated with scrub typhus.

BMC Infect Dis 2020 Apr 17;20(1):286. Epub 2020 Apr 17.

Division of Infectious Diseases, Department of Internal Medicine, Inha University College of Medicine, 7-206, Shinheung-Dong, Jung-Gu, Incheon, 22332, Republic of Korea.

Background: Henoch-Schönlein purpura (HSP) may be caused by several allergens. However, to date, HSP caused by Orientia tsutsugamushi has not been reported. Here, we report an unusual rash with features of HSP caused by Orientia tsutsugamushi. Read More

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http://dx.doi.org/10.1186/s12879-020-05001-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165380PMC

Intramuscular Hematoma as a Manifestation of IgA Vasculitis.

Pediatrics 2020 May 14;145(5). Epub 2020 Apr 14.

Eastern Virginia Medical School and Children's Hospital of The King's Daughters, Norfolk, Virginia.

We describe an atypical pediatric case of immunoglobulin A vasculitis (IgAV), also referred to as Henoch-Schönlein purpura, in which formation of spontaneous hematoma of the paraspinal muscles developed. Spontaneous or unprovoked hematomas rarely occur in IgAV. These manifestations have not been described specifically in the pediatric literature as coinciding with IgAV. Read More

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http://dx.doi.org/10.1542/peds.2019-1668DOI Listing

The renal reality of adult Henoch-Schönlein purpura.

Authors:
Warren R Heymann

J Am Acad Dermatol 2020 Jun 9;82(6):1303-1304. Epub 2020 Apr 9.

Cooper Medical School of Rowan University, Marlton, New Jersey. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.03.104DOI Listing

Henoch-Schönlein Purpura Presenting in Association With Neuroblastoma: A Case Report.

Front Pediatr 2020 28;8:77. Epub 2020 Feb 28.

Division of Pediatric Rheumatology, University of Minnesota, Minneapolis, MN, United States.

Henoch-Schönlein purpura (HSP) is a common systemic vasculitis affecting children. It is managed in the outpatient setting and rarely associated with malignancy. We present a case of neuroblastoma in a 7-year-old boy diagnosed after suspected HSP. Read More

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http://dx.doi.org/10.3389/fped.2020.00077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093007PMC
February 2020

Active Surveillance of Adverse Events Following Human Papillomavirus Vaccination: Feasibility Pilot Study Based on the Regional Health Care Information Platform in the City of Ningbo, China.

J Med Internet Res 2020 Jun 1;22(6):e17446. Epub 2020 Jun 1.

Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing, China.

Background: Comprehensive safety data for vaccines from post-licensure surveillance, especially active surveillance, could guide administrations and individuals to make reasonable decisions on vaccination. Therefore, we designed a pilot study to assess the capability of a regional health care information platform to actively monitor the safety of a newly licensed vaccine.

Objective: This study aimed to conduct active surveillance of human papillomavirus (HPV) vaccine safety based on this information platform. Read More

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http://dx.doi.org/10.2196/17446DOI Listing

Gastrointestinal involvement in adult IgA vasculitis (Henoch-Schönlein purpura): updated picture from a French multicentre and retrospective series of 260 cases.

Rheumatology (Oxford) 2020 Mar 24. Epub 2020 Mar 24.

Université Paris Descartes.

Objectives: To describe the clinical presentation, treatments and prognosis of gastrointestinal (GI) involvement in adult IgA vasculitis (IgAV).

Methods: Data from 260 adults with IgAV included in a French multicentre retrospective survey were analysed. Presentation and outcomes of patients with (GI+) and without (GI-) GI involvement were compared. Read More

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http://dx.doi.org/10.1093/rheumatology/keaa104DOI Listing

Predictive role of neutrophil to lymphocyte ratio and mean platelet volume in Henoch-Schönlein purpura related gastrointestinal and renal involvement.

Arch Argent Pediatr 2020 Apr;118(2):139-142

Department of Pediatric Rheumatology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.

Background: Henoch-Schönlein purpura (HSP) is a systemic small-vessel vasculitis that occurs mainly in children. The aim was to evaluate the blood neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV) in patients with HSP and to investigate the relationship with gastrointestinal and renal involvement.

Methods: Children with HSP and healthy individuals as controls were included. Read More

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http://dx.doi.org/10.5546/aap.2020.eng.139DOI Listing

Urinary proteomics of Henoch-Schönlein purpura nephritis in children using liquid chromatography-tandem mass spectrometry.

Clin Proteomics 2020 12;17:10. Epub 2020 Mar 12.

1Department of Pediatrics, Jinling Hospital, the First School of Clinical Medicine, Southern Medical University, No. 305 Zhongshan East Road, Nanjing, 210002 Jiangsu China.

Background: Henoch-Schönlein purpura nephritis (HSPN) is the principal cause of morbidity and mortality in children with Henoch-Schönlein purpura (HSP). However, the criteria for risk assessment currently used is not satisfactory. The urine proteome may provide important clues to indicate the development of HSPN. Read More

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http://dx.doi.org/10.1186/s12014-020-09274-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066733PMC

Clinical outcome in pediatric refractory gastrointestinal Henoch-Schönlein purpura treated with mycophenolate mofetil.

Eur J Pediatr 2020 Mar 6. Epub 2020 Mar 6.

Department of Pediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510120, People's Republic of China.

The aim of the present study was to investigate the clinical outcome of mycophenolate mofetil in pediatric refractory gastrointestinal (GI) Henoch-Schönlein purpura (HSP). Most of the HSP patients with GI symptoms may benefit from early introduction of glucocorticoid; however, a number of patients still do not achieve remission following the administration of steroids. Therefore, the present study was to investigate the clinical features and the clinical outcome of mycophenolate mofetil in refractory GI HSP. Read More

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http://dx.doi.org/10.1007/s00431-020-03592-wDOI Listing

Uveitis and Henoch-Schönlein purpura: case report and literature review.

Clin Exp Rheumatol 2020 Mar-Apr;38 Suppl 124(2):238. Epub 2020 Mar 5.

Paediatric Rheumatology Unit, Anna Meyer Children's University Hospital, School of Human Health Science, Florence, and Rheumatology Unit, Anna Meyer Children's Hospital, Florence, Neurofarba Department, University of Florence, Italy.

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Effect of intraocular anti-VEGF on cystoid macular edema associated with Henoch-Schonlein purpura-a case report.

BMC Ophthalmol 2020 Feb 28;20(1):79. Epub 2020 Feb 28.

Department of Ophthalmology, Changhai Hospital, Second Military Medical University, Shanghai, China.

Background: To report a bilateral cystoid macular edema associated with Henoch-Schonleinpurpura.

Case Presentation: A 21-year-old man presented a bilateral, painless, and bilateral blurred vision for 5 weeks with visual acuity (VA) of 6/12 on the right eye and 6/48 on the left. FA and OCT showed bilateral cystoid macular edema, and the fundus photograph showed retinal hemorrhages. Read More

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http://dx.doi.org/10.1186/s12886-020-01351-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049220PMC
February 2020

Rare combination of infective endocarditis in a drug abuser with Henoch-Schoenlein purpura.

J Biol Regul Homeost Agents 2020 Feb 28;34(1). Epub 2020 Feb 28.

Clinic for Internal Disease Intermedica, Nis, Serbia.

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http://dx.doi.org/10.23812/19-301-LDOI Listing
February 2020

Epidemiology of 10-year paediatric renal biopsies in the region of southern Croatia.

BMC Nephrol 2020 Feb 26;21(1):65. Epub 2020 Feb 26.

Department of Pediatrics, University Hospital Centre Split, 21000, Split, Croatia.

Background: Information about renal diseases in children is available from national registries of renal biopsies. Aim of the study was to compare the clinical presentation of glomerular diseases and tubulointerstitial space diseases with pathohistological diagnosis of indicated renal biopsies from pediatric population in the Croatian region of Dalmatia.

Methods: Out of 231 pediatric patients with suspected glomerular and tubulointerstitial diseases, 54 underwent ultrasound-guided renal biopsy at University Hospital of Split. Read More

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http://dx.doi.org/10.1186/s12882-020-01727-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045640PMC
February 2020

Rituximab treatment for IgA vasculitis: A systematic review.

Autoimmun Rev 2020 Apr 13;19(4):102490. Epub 2020 Feb 13.

Conective Tissue Diseases Unit, Department of Internal Medicine, Hospital Clínico Universitario de Salamanca, Salamanca, Spain; Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain; Department of Medicine, Faculty of Medicine, University of Salamanca, Salamanca, Spain. Electronic address:

Background: Immunoglobulin A vasculitis (IgAV) is a systemic small vessel vasculitis for which treatment of severe cases is usually based on glucocorticoids and other conventional immunosuppressive drugs. The role of rituximab for resistant or refractory cases has been explored in isolated case reports and small series.

Aims: To perform a literature review of all pediatric and adult patients with IgAV treated with rituximab (RTX) and to assess disease characteristics, RTX efficacy and safety. Read More

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http://dx.doi.org/10.1016/j.autrev.2020.102490DOI Listing

Safety and Efficacy Evaluation of Traditional Chinese Medicine (Qingre-Lishi-Yishen Formula) Based on Treatment of Regular Glucocorticoid Combined with Cyclophosphamide Pulse in Children Suffered from Moderately Severe Henoch-Schonlein Purpura Nephritis with Nephrotic Proteinuria.

Evid Based Complement Alternat Med 2020 27;2020:3920735. Epub 2020 Jan 27.

Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, National Centre for Children's Health, Beijing 100045, China.

Objective: At present, the most appropriate management of Henoch-Schonlein purpura nephritis (HSPN) with nephrotic-range proteinuria still remains controversial; thus, the purpose of this study is to evaluate safety and efficacy of traditional Chinese medicine (TCM), Qingre-Lishi-Yishen Formula (QLYF), integrated with regular oral glucocorticoid and cyclophosphamide intravenous pulse therapeutic regimen in children suffered from moderately severe HSPN with nephrotic proteinuria.

Methods: From 1 January 2012, to 1 January 2016, totally 150 hospitalized children suffered from HSPN with nephrotic proteinuria were included. All were treated with glucocorticoid and cyclophosphamide, and 100 of them were treated with integrative traditional Chinese decoction QLYF. Read More

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http://dx.doi.org/10.1155/2020/3920735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007748PMC
January 2020

Serosal surface small vessel vasculitis in Henoch-Schonlein purpura.

Pediatr Neonatol 2020 Jan 25. Epub 2020 Jan 25.

Island Hospital, Macalister Road, George Town, 10450, Penang, Malaysia.

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http://dx.doi.org/10.1016/j.pedneo.2020.01.002DOI Listing
January 2020

Beneficial Effects of Qingzixiaoban Granule on Henoch-Schönlein Purpura Nephritis Mice through Inhibiting Immune Complex Deposition and Th2 Immunodeviation.

Evid Based Complement Alternat Med 2019 16;2019:3050248. Epub 2019 Oct 16.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Background: Henoch-Schönlein purpura nephritis (HSPN) is the principal cause of morbidity and mortality in Henoch-Schönlein purpura (HSP). However, there is no absolute consensus for the best management of severe HSPN till now. Qingzixiaoban Granule (QZXB GR), a traditional Chinese medicine formula, has been applied to treat HSP in clinical in China. Read More

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http://dx.doi.org/10.1155/2019/3050248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817923PMC
October 2019