5,194 results match your criteria Henoch-Schonlein Purpura


Gastrointestinal Biopsy in Henoch-Schönlein Purpura: A Great Diagnostic Contribution.

Eur J Case Rep Intern Med 2017 27;4(9):000662. Epub 2017 Sep 27.

Gastroenterology Department, Farhat Hached Hospital, Sousse, Tunisia.

Henoch-Schönlein purpura is an IgA-mediated immune vasculitis which is characterized by purpuric lesions and osteoarticular, intestinal and sometimes renal manifestations. The histopathological substrate of this entity is leucocytoclastic vasculitis (LCV) with IgA deposits seen on immunohistochemistry. We here report the case of a 27-year-old woman with abdominal pain and cutaneous purpura. Read More

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http://dx.doi.org/10.12890/2017_000662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346849PMC
September 2017
2 Reads

Food-induced IgA Vasculitis (Henoch-Schönlein Purpura).

Eur J Case Rep Intern Med 2018 22;5(2):000774. Epub 2018 Feb 22.

Internal Medicine Department, Hospital Universitario Miguel Servet, Zaragoza, Spain.

Immunoglobulin A (IgA) vasculitis is a rare entity in adults. It can be triggered by allergens such as drugs, food, or insect bites. We present a case of an adult male with a cutaneous IgA vasculitis of palpable purpura after eating canned sardines. Read More

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http://dx.doi.org/10.12890/2017_000774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346936PMC
February 2018

The clinical spectrum of Henoch-Schönlein purpura in children: a single-center study.

Clin Rheumatol 2019 Feb 8. Epub 2019 Feb 8.

Kanuni Sultan Süleyman Research and Training Hospital, Department of Pediatric Rheumatology, University of Health Science, No: 46/1, Kucukcekmece, 34303, Istanbul, Turkey.

Objectives: Henoch-Schönlein purpura (HSP) is the most common vasculitis of children. The aim of this study is to evaluate the demographic and clinic findings of patients with HSP and also to determine predictive factors for assessing the development of gastrointestinal system (GIS) and renal involvement.

Methods: This study was performed prospectively among children with HSP who are under 18 years of age and being followed-up in the Pediatric Rheumatology Unit of Health Sciences University Kanuni Sultan Süleyman Training and Research Hospital between January 2016 and January 2018. Read More

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http://dx.doi.org/10.1007/s10067-019-04460-1DOI Listing
February 2019

Clinical course & management of childhood nephrotic syndrome in Germany: a large epidemiological ESPED study.

BMC Nephrol 2019 Feb 7;20(1):45. Epub 2019 Feb 7.

Department of Radiology, Pediatric Radiology, University Hospital of Bonn, Bonn, Germany.

Background: Nephrotic syndrome (NS) is one of the most frequent occurring chronic kidney diseases in childhood, despite its rarely occurrence in the general population. Detailed information about clinical data of NS (e.g. Read More

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http://dx.doi.org/10.1186/s12882-019-1233-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367765PMC
February 2019
5 Reads

[Adult-onset Henoch-Schönlein purpura mimicking infectious enteritis].

Rinsho Ketsueki 2019 ;60(1):51-56

Department of Pathology, Iwate Medical University.

A 37-year-old male with chief complaints of vomiting, abdominal pain, and diarrhea presented to our hospital in June 2017. A blood test detected increased inflammatory response, and a computed tomography scan showed that wall thickening extended from the terminal ileum to the entire large intestine. Bacterial enteritis was suspected because his household members developed infectious enteritis; however, his symptoms did not improve after antibiotic treatment. Read More

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http://dx.doi.org/10.11406/rinketsu.60.51DOI Listing
January 2019
1 Read

Hemorrhagic Bullous Henoch-Schönlein Purpura: Case Report and Review of the Literature.

Front Pediatr 2018 22;6:413. Epub 2019 Jan 22.

Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany.

Henoch-Schönlein Purpura (HSP) or IgA vasculitis is the most common systemic vasculitis of childhood and may affect skin, joints, gastrointestinal tract, and kidneys. Skin manifestations of HSP are characteristic and include a non-thrombocytopenic palpable purpura of the lower extremities and buttocks. Rarely, HSP may initially present as or evolve into hemorrhagic vesicles and bullae. Read More

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https://www.frontiersin.org/article/10.3389/fped.2018.00413/
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http://dx.doi.org/10.3389/fped.2018.00413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349767PMC
January 2019
9 Reads

From Schönlein-Henoch purpura to IgA-vasculitis: pathogenetic aspects of the disease.

Ter Arkh 2018 Nov;90(10):109-114

I.M. Sechenov First Moscow State Medical University Ministry of Health of Russia (Sechenov University), Moscow, Russia.

Investigation's history and nomenclature's evolution of the IgA-vasculitis are presented in the article. Pathogenesis of the renal and skin damages is discussed in details, particularly abnormalities of the IgA-immunity and systemic endotoxemia. Relevant world's literature is cited. Read More

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http://dx.doi.org/10.26442/terarkh20189010109-114DOI Listing
November 2018
2 Reads

Imaging in small and medium vessel vasculitis.

Int J Rheum Dis 2019 Jan;22 Suppl 1:78-85

Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Vasculitis includes a group of disorders characterized by inflammation of the vessel wall and classified based on the diameter of the predominantly involved vessels. Granulomatosis with polyangiitis, microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis and Henoch-Schonlein purpura are the important entities in the small vessel vasculitis group, while polyarteritis nodosa and Kawasaki disease represent the medium vessel vasculitis group. The clinical manifestations may be non-specific and there may be considerable overlap with the other disorders. Read More

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http://dx.doi.org/10.1111/1756-185X.13390DOI Listing
January 2019
1 Read

Leukocytoclastic vasculitis with late-onset Henoch-Schönlein purpura after trifluridine/tipiracil treatment.

Dermatol Online J 2018 Oct 15;24(10). Epub 2018 Oct 15.

Department of Dermatology, The University of Texas McGovern Medical School, Houston, Texas.

Trifluridine/tipiracil has been approved for the treatment of refractory metastatic colorectal cancer. Adverse effects of this drug combination include leukopenia, neutropenia, fatigue, diarrhea, and vomiting. We present a case of trifluridine/tipiracil-induced leukocytoclastic vasculitis (LCV) with late-onset Henoch-Schönlein purpura (HSP) in a 42-year-old man with metastatic appendiceal cancer. Read More

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October 2018
2 Reads

[Role of hypomethylation of suppressor of cytokine signaling in T helper 17 cell/regulatory T cell imbalance in children with Henoch-Schönlein purpura].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Jan;21(1):38-44

Department of Pediatric Cardiology, Nephrology and Rheumatism, Affliated Hospital of Qingdao University, Qingdao, Shandong 266003, China.

Objective: To investigate the association between suppressor of cytokine signaling (SOCS) hypomethylation and T helper 17 (Th17) cell/regulatory T (Treg) cell imbalance in children with Henoch-Schönlein purpura (HSP) and the immune pathogenesis of HSP.

Methods: A total of 32 children in the acute stage of HSP who were hospitalized from May 2014 to January 2015 were enrolled as subjects, and 28 children who underwent physical examination were enrolled as normal control group. ELISA was used to measure the plasma level of interleukin-6 (IL-6). Read More

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January 2019

Characterization of scrotal involvement in children and adolescents with IgA vasculitis.

Adv Rheumatol 2018 Nov 3;58(1):38. Epub 2018 Nov 3.

Pediatric Rheumatology Unit, Children's Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, SP, Av. Dr. Eneas Carvalho Aguiar, 647 - Cerqueira César, São Paulo, SP, 05403-000, Brazil.

Objective: To characterize scrotal involvement in children and adolescents with IgA vasculitis.

Methods: A cross-sectional retrospective study included 296 IgA vasculitis (EULAR/PRINTO/PRES criteria) patients, 150/296 (51%) were males and assessed by demographic/clinical/laboratory and treatments. Scrotal involvement was defined by the presence of scrotal edema and/or pain/tenderness in physical examination and/or testicular Doppler ultrasound abnormalities. Read More

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http://dx.doi.org/10.1186/s42358-018-0039-3DOI Listing
November 2018

The change of Th17/Treg cells and IL-10/IL-17 in Chinese children with Henoch-Schonlein purpura: A PRISMA-compliant meta-analysis.

Medicine (Baltimore) 2019 Jan;98(3):e13991

Department of Pediatrics.

Background: To date, the relationship of Th17 and Treg cells to Henoch-Schonlein purpura (HSP) in children remains controversial. Therefore, a systematic review and meta-analysis was conducted to reveal the potential role of the Th17 and Treg cells in children in acute stage of HSP.

Methods: PubMed, Embase, Web of Science and China National Knowledge Internet (CNKI) were systematically searched for eligible studies up to November 03, 2017. Read More

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http://dx.doi.org/10.1097/MD.0000000000013991DOI Listing
January 2019
1 Read
5.723 Impact Factor

Differential expression of long non-coding RNA and mRNA in children with Henoch-Schönlein purpura nephritis.

Exp Ther Med 2019 Jan 30;17(1):621-632. Epub 2018 Nov 30.

Department of Pediatrics, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110032, P.R. China.

Long non-coding RNAs (lncRNAs) serve an essential role in regulating immunological functions. However, their impact on Henoch-Schönlein purpura nephritis (HSPN), has remained elusive. The present study determined the expression of lncRNAs and mRNAs in the peripheral blood of 6 children with HSPN and recruited 4 healthy children for comparative study. Read More

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http://www.spandidos-publications.com/10.3892/etm.2018.7038
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http://dx.doi.org/10.3892/etm.2018.7038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307475PMC
January 2019
6 Reads

Acute abdominal pain: Henoch-Schönlein purpura case in a young adult, a rare but important diagnosis.

Clin Med (Lond) 2019 Jan;19(1):77-79

Royal Victoria Hospital, Belfast, UK.

Henoch-Schönlein purpura (HSP), also known as IgA vasculitis, is a systemic vasculitis which is the most common vasculitis in children. The incidence in adults varies from 3.4 to 14. Read More

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http://dx.doi.org/10.7861/clinmedicine.19-1-77DOI Listing
January 2019
2 Reads

Direct Immunofluorescence Results of the Skin Biopsy and Frequency of Systemic Involvement in Children with Henoch-Schonlein Purpura.

Fetal Pediatr Pathol 2019 Jan 2:1-6. Epub 2019 Jan 2.

b Department of Pathology , Tehran University of Medical Sciences , Tehran , Iran.

Objective: Henoch-Schonlein purpura (HSP) is a common vasculitis in children that can present with multi-organ involvement. The aim of this study is to investigate the correlation between direct immunofluorescence (DIF) results and the systemic involvements of the HSP in pediatric patients.

Material And Methods: Those HSP patients with leukocytoclastic vasculitis on their biopsies who also had documented immunoglobulin/complement deposition by DIF were included in our study. Read More

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http://dx.doi.org/10.1080/15513815.2018.1552733DOI Listing
January 2019
1 Read

Clinicopathological profile of pediatric renal biopsies at a tertiary care hospital, Pakistan.

Saudi J Kidney Dis Transpl 2018 Nov-Dec;29(6):1403-1409

The Kidney Center, Karachi, Pakistan.

Renal biopsy is an important tool for the diagnosis of acute and chronic glomerular diseases in children. We aimed to analyze the spectrum of clinical indications and histopathological patterns (HPP) in children who underwent renal biopsy (RB). This is a retrospective review of case records of 108 renal biopsies carried out from January 2010 to December 2015 at the Pediatric Nephrology Department, National Institute of Child Health Karachi, Pakistan. Read More

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http://www.sjkdt.org/text.asp?2018/29/6/1403/248290
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http://dx.doi.org/10.4103/1319-2442.248290DOI Listing
December 2018
13 Reads

Henoch-Schonlein purpura in pregnancy: A case report.

Obstet Med 2018 Dec 7;11(4):195-197. Epub 2018 Mar 7.

Internal Medicine Division, Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.

Henoch-Schonlein purpura is a relatively common pediatric vasculitis. Very few cases of Henoch-Schonlein purpura during pregnancy have been described. Henoch-Schonlein purpura is variable in its presentation, from completely benign to possibly catastrophic complications. Read More

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http://dx.doi.org/10.1177/1753495X17745391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295767PMC
December 2018

Acute hemorrhagic edema of infancy: guide to prevent misdiagnosis.

Cutis 2018 Nov;102(5):359-362

Department of Dermatology, Geisinger Health System, Danville, Pennsylvania, USA.

We report the case of a 10-month-old previously healthy boy who presented with acute rash, edema, and low-grade fever in the setting of recent diarrhea. We differentiate between acute hemorrhagic edema of infancy (AHEI) and Henoch-Schönlein purpura (HSP). Read More

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November 2018
8 Reads

Successful treatment of hemorrhagic bullous Henoch-Schonlein purpura with intravenous immunoglobulins.

Pediatr Dermatol 2019 Jan 18;36(1):e34-e36. Epub 2018 Dec 18.

Department of Paediatrics, Santobono-Pausilipon Children's Hospital, Naples, Italy.

Henoch-Schonlein purpura (HSP) is the most common systemic vasculitis in childhood. There is no consensus about the management for isolated cutaneous manifestations in HSP. We describe a case of HSP presenting with severe skin lesions that did not respond to standard therapy with corticosteroids. Read More

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http://dx.doi.org/10.1111/pde.13715DOI Listing
January 2019
1 Read

Late Relapse of Henoch-Schönlein Purpura in an Adolescent Presenting as Severe Gastroduodenitis.

Front Pediatr 2018 20;6:355. Epub 2018 Nov 20.

Pediatric Department, Anna Meyer Children's Hospital, Florence, Italy.

Henoch-Schönlein purpura is a systemic vasculitis, commonly affecting children. Gastrointestinal manifestations are observed in 50-75% of patients; it is well known they may occur before skin lesions in about 20% of cases during the first vasculitic episode. Relapses occur in about one third of patients, typically within 4 months from the initial presentation and with milder symptoms. Read More

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https://www.frontiersin.org/article/10.3389/fped.2018.00355/
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http://dx.doi.org/10.3389/fped.2018.00355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256137PMC
November 2018
20 Reads

Henoch-Schönlein Purpura After Living Donor Liver Transplantation: Report of the First Case.

Transplant Proc 2018 Dec 9;50(10):4050-4052. Epub 2018 Mar 9.

Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Henoch-Schönlein purpura (HSP) is a systemic vasculitis affecting the small vessels that mainly presents in children and young adults. It is characterized by tissue deposition of immunoglobulin A (IgA) immune complexes with the classic manifestations of purpura, arthritis, arthralgia, and gastrointestinal and renal involvements. We report a case of HSP nephritis that occurred 2 years after living-donor liver transplantation (LDLT). Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.02.072DOI Listing
December 2018
1 Read

Predisposing factors of childhood Henoch-Schnlein purpura in Anhui province, China.

J Investig Med 2018 Dec 6. Epub 2018 Dec 6.

Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Henoch-Schönlein purpura (HSP) is a common autoimmune vasculitis in childhood. The detailed pathogenesis of HSP is still unclear, whereas several types of predisposing factors have been proved to be the initial step. The objectives of present study were to analyze the distribution of predisposing factors, association of the predisposing factors with clinical manifestations and HSP relapse/recurrence. Read More

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http://jim.bmj.com/lookup/doi/10.1136/jim-2018-000906
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http://dx.doi.org/10.1136/jim-2018-000906DOI Listing
December 2018
6 Reads
1.503 Impact Factor

Henoch-schonlein Purpura Nephritis with Renal Interstitial Lesions.

Open Med (Wars) 2018 27;13:597-604. Epub 2018 Nov 27.

Institute of Pathology, Basic Medical College of Lanzhou University, Lanzhou 730000, Gansu Province, China.

Objective: To investigate the clinical pathology and prognosis & outcome of Henoch-Schonlein purpura nephritis (HSPN) with renal interstitial lesions.

Methods: All 148 patients were analyzed for clinical, renal pathological, and prognostic features. Patients with no, mild, and moderate- severe renal tubulo-interstitial lesions were included in group A, B and C, respectively. Read More

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http://dx.doi.org/10.1515/med-2018-0088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272053PMC
November 2018
4 Reads

[Effect of miR-21 on the expression of interleukin-10 in B cell of patients with Henoch-Schonlein purpura].

Zhonghua Er Ke Za Zhi 2018 Dec;56(12):939-944

Rheumatology & Immunology Department of Shenzhen Children's Hospital, Shenzhen 518038, China.

To investigate the effect of microRNAs (miR)-21 on the expression of interleukin (IL)-10 in B cell of patients with Henoch-Schonlein purpura (HSP). From March 2016 to January 2017, twenty-four children with HSP hospitalized in rheumatology and immunology department of Shenzhen Children's Hospital were enrolled into the study, including 12 males and 12 females. Patients were divided into purpura nephritis group (HSPN, 14 cases) and non-nephritis group (NHSPN, 10 cases). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2018.12.010DOI Listing
December 2018
3 Reads

MEFV gene variants in children with Henoch-Schönlein purpura and association with clinical manifestations: a single-center Mediterranean experience.

Postgrad Med 2019 Jan 12;131(1):68-72. Epub 2018 Dec 12.

a Department of Pediatric Rheumatology , Cukurova University Faculty of Medicine , Adana , Turkey.

Objectives: Henoch-Schönlein purpura (HSP) is characterized by non-thrombocytopenic palpable purpura, abdominal pain, and arthralgia/arthritis. We aimed to describe the clinical presentations of children with HSP in a single center and compare the prevalence of each manifestations between patients with MEFV variants, particularly in exon 10 and those without.

Methods: This cohort retrospectively included 144 HSP (59 females, 85 males) patients without Familial Mediterranean Fever (FMF) symptoms and followed for at least 6 months. Read More

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http://dx.doi.org/10.1080/00325481.2019.1552479DOI Listing
January 2019
8 Reads

Atypical purpura location in a pediatric patient with Henoch-Schönlein purpura: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13294

Department of Laboratory, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Rationale: The presence of purpura is a compulsory criteria for the diagnosis of Henoch-Schönlein purpura (HSP). Typical purpura of HSP is distributed symmetrically over the extensor surfaces of the lower limbs, buttocks, and forearms with the occasional involvement of trunk and face in children. It occurs only involving the bottom of the feet has never been reported. Read More

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http://dx.doi.org/10.1097/MD.0000000000013294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283069PMC
November 2018
9 Reads

Features distinguishing juvenile idiopathic arthritis among children with musculoskeletal complaints.

World J Pediatr 2018 Nov 29. Epub 2018 Nov 29.

Division of Rheumatology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.

Background: Musculoskeletal (MSK) complaints in children vary, ranging from benign, self-limited conditions to serious disorders. Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease, initially presenting with MSK complaints. Delayed diagnosis and appropriate treatment have an enormous impact on the long-term outcomes and the level of disability. Read More

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http://dx.doi.org/10.1007/s12519-018-0212-0DOI Listing
November 2018
3 Reads

Cardiovascular, thromboembolic and renal outcomes in IgA vasculitis (Henoch-Schönlein purpura): a retrospective cohort study using routinely collected primary care data.

Ann Rheum Dis 2019 Feb 28;78(2):261-269. Epub 2018 Nov 28.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK.

Background: IgA vasculitis (IgAV, Henoch-Schönlein purpura) is a small-vessel vasculitis most common in children but also occurring in adults. Case series have suggested that IgAV may be associated with cardiovascular disease and venous thromboembolism, but this has not been evaluated in population-based studies. Renal disease and hypertension are possible complications of the disease with unknown incidence. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214142DOI Listing
February 2019
2 Reads

Intussusception as the main manifestation of Schönlein-Henoch purpura in an adult patient.

Gastroenterol Hepatol 2018 Nov 24. Epub 2018 Nov 24.

Servicio de Medicina Interna, Hospital Universitari del Sagrat Cor, Barcelona, España.

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http://dx.doi.org/10.1016/j.gastrohep.2018.09.009DOI Listing
November 2018
1 Read

Rare and striking complication of Henoch-Schönlein purpura.

Arch Dis Child 2018 Nov 23. Epub 2018 Nov 23.

Department of Pediatrics, University Hospitals Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1136/archdischild-2018-316134DOI Listing
November 2018
1 Read

Significance of histological crescent formation in patients with IgA vasculitis (Henoch-Schönlein purpura)-related nephritis: a cohort in the adult Chinese population.

BMC Nephrol 2018 Nov 22;19(1):334. Epub 2018 Nov 22.

National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, People's Republic of China.

Background: IgA vasculitis (IgAV, formerly Henoch-Schönlein purpura) is a type of systemic vasculitis. This study aimed to explore the clinicopathological features, treatment and renal outcomes of adult IgAV-related nephritis (Henoch-Schönlein purpura nephritis) patients with different degrees of crescent formation.

Methods: Adult patients with biopsy-proven IgAV-related nephritis in Nanjing Jinling Hospital were enrolled and divided into three groups as follows: control (no crescents, n = 257), group 1 (crescents < 25%, n = 381), and group 2 (crescents ≥25%, n = 60). Read More

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http://dx.doi.org/10.1186/s12882-018-1117-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249918PMC
November 2018
7 Reads
1.520 Impact Factor

Cord-derived mesenchymal stem cells therapy for liver cirrhosis in children with refractory Henoch-Schonlein purpura: A case report.

Medicine (Baltimore) 2018 Nov;97(47):e13287

Department of Pediatrics, Shandong Provincial Qianfoshan Hospital of Shandong University, Jinan, China.

Rationale: To explore the curative effect of human umbilical cord-derived mesenchymal stem cell (ucMSC) therapy for patients with liver cirrhosis complicated with immune thrombocytopenia and refractory Henoch-Schonlein purpura (HSP).

Patient Concerns: A 12-year-old boy presented to our hospital with an 11-month history of purpura on the skin of both lower limbs accompanied by thrombocytopenia. The patient had a history of repeated swelling and painful dorsum pedis, followed by skin redness. Read More

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http://dx.doi.org/10.1097/MD.0000000000013287DOI Listing
November 2018
14 Reads

Expression of DENDRIN in several glomerular diseases and correlation to pathological parameters and renal failure - preliminary study.

Diagn Pathol 2018 Nov 20;13(1):90. Epub 2018 Nov 20.

Department of Pathology, Forensic medicine and Cytology, University Hospital Centre Split, Split, Croatia.

Background: In glomerular injury dendrin translocates from the slit diaphragm to the podocyte nucleus, inducing apoptosis. We analyzed dendrin expression in IgA glomerulonephritis and Henoch Schönlein purpura (IgAN/HSP) versus in podocytopathies minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS), and compared it to pathohistological findings and renal function at the time of biopsy and the last follow-up.

Methods: Twenty males and 13 females with median of age 35 years (min-max: 3-76) who underwent percutaneous renal biopsy and had diagnosis of glomerular disease (GD) were included in this retrospective study. Read More

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http://dx.doi.org/10.1186/s13000-018-0767-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247684PMC
November 2018
39 Reads

Immunoglobulin A Nephropathy and Immunoglobulin A Vasculitis.

Pediatr Clin North Am 2019 02;66(1):101-110

Department of Pediatrics, Medical University of South Carolina, 96 Jonathan Lucas Street, 428 CSB, MSC 608, Charleston, SC 29425, USA. Electronic address:

Henoch-Schönlein purpura nephritis and immunoglobulin A nephropathy are common glomerulopathies in the pediatric population that deserve special attention. In some cases the primary care provider can follow the patient but others need more intensive management. Delaying this treatment can lead to worse morbidity. Read More

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http://dx.doi.org/10.1016/j.pcl.2018.08.008DOI Listing
February 2019
2 Reads

Recurrent Henoch Schönlein purpura without renal involvement successfully treated with methotrexate.

Scott Med J 2018 Nov 19:36933018809816. Epub 2018 Nov 19.

5 Professor, Department of Pediatric Rheumatology, Cukurova University Faculty of Medicine, Turkey.

Introduction: Henoch Schönlein purpura is characterised by palpable purpura, abdominal pain, arthritis/arthralgia, often with a self-limiting course. Herein, we report a patient with recurrent Henoch Schönlein purpura and severe gastrointestinal involvement, successfully treated with methotrexate.

Case Presentation: A 12-year-old boy was admitted to our department with palpable purpura, abdominal pain and arthralgia. Read More

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http://dx.doi.org/10.1177/0036933018809816DOI Listing
November 2018
11 Reads

Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study.

Kidney Int Rep 2018 Nov 3;3(6):1373-1384. Epub 2018 Aug 3.

Department of Medicine, Division of Nephrology, Columbia University College of Physicians and Surgeons, New York, New York, USA.

Introduction: The Cure Glomerulonephropathy Network (CureGN) is a 66-center longitudinal observational study of patients with biopsy-confirmed minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, or IgA nephropathy (IgAN), including IgA vasculitis (IgAV). This study describes the clinical characteristics and treatment patterns in the IgA cohort, including comparisons between IgAN versus IgAV and adult versus pediatric patients.

Methods: Patients with a diagnostic kidney biopsy within 5 years of screening were eligible to join CureGN. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24680249183017
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http://dx.doi.org/10.1016/j.ekir.2018.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224619PMC
November 2018
12 Reads

Rituximab treatment for chronic steroid-dependent Henoch-Schonlein purpura: 8 cases and a review of the literature.

Pediatr Rheumatol Online J 2018 Nov 14;16(1):71. Epub 2018 Nov 14.

Department of Pediatrics, Division of Rheumatology, University of Alabama at Birmingham, 1600 7th Ave S, CPPN G10, Birmingham, AL, 35233, USA.

Background: Henoch-Schonlein purpura (HSP) is a small vessel vasculitis that is characterized by non-thrombocytopenic purpura, abdominal pain, arthritis, and glomerulonephritis. Typically, HSP is self-limited requiring only supportive care, but more severe cases may require corticosteroid (CS) treatment. Rarely, a subset of these patients has persistent rash, arthritis, abdominal involvement, or renal disease despite treatment with CS, or has disease recurrence on CS tapering. Read More

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https://ped-rheum.biomedcentral.com/articles/10.1186/s12969-
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http://dx.doi.org/10.1186/s12969-018-0285-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236882PMC
November 2018
25 Reads

CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease.

Am J Kidney Dis 2019 Feb 9;73(2):218-229. Epub 2018 Nov 9.

Center for Translational Science, Children's National Health System, Washington, DC.

Rationale & Objectives: Glomerular diseases, including minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and immunoglobulin A (IgA) nephropathy, share clinical presentations, yet result from multiple biological mechanisms. Challenges to identifying underlying mechanisms, biomarkers, and new therapies include the rarity of each diagnosis and slow progression, often requiring decades to measure the effectiveness of interventions to prevent end-stage kidney disease (ESKD) or death.

Study Design: Multicenter prospective cohort study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02726386183093
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http://dx.doi.org/10.1053/j.ajkd.2018.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348011PMC
February 2019
18 Reads

Steroid- and immunosuppressant-based protocol of Henoch-Schönlein purpura nephritis without angiotensin inhibitors in the acute phase: case series with correlation to histology.

Minerva Pediatr 2018 Nov 7. Epub 2018 Nov 7.

Ichinomiya Medical Treatment & Habilitation Center, Ichinomiya-city, Aichi, Japan -

Background: The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines suggest initially using angiotensin-converting-enzyme inhibitors (ACE-Is) and/or angiotensin receptor blockers (ARBs) to treat Henoch-Schönlein purpura nephritis (HSPN). However, these guidelines might overlook the potential benefits of aggressive therapy. Therefore, we evaluated the efficacy of an HSPN protocol that primarily uses steroids and immunosuppressants, without ACE-Is or ARBs. Read More

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https://www.minervamedica.it/index2.php?show=R15Y9999N00A181
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http://dx.doi.org/10.23736/S0026-4946.18.05324-0DOI Listing
November 2018
14 Reads

Correlation between endocapillary proliferative and nephrotic-range proteinuria in children with Henoch-Schönlein purpura nephritis.

Pediatr Nephrol 2018 Nov 10. Epub 2018 Nov 10.

Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA.

Background: The endocapillary proliferative (EP) lesion is not included in the International Study of Kidney Disease in Children (ISKDC) pathological classification of Henoch-Schönlein purpura nephritis (HSPN). The main objective of the study was to determine the pathological importance of EP in the development of proteinuria in children with Henoch-Schönlein purpura nephritis (HSPN).

Methods: The pathological features of 148 HSPN children with nephrotic-range proteinuria were investigated retrospectively. Read More

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http://link.springer.com/10.1007/s00467-018-4134-9
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http://dx.doi.org/10.1007/s00467-018-4134-9DOI Listing
November 2018
11 Reads
2.860 Impact Factor

Acute renal insufficiency and pancreatitis in a child with atypical Henoch-Schönlein purpura: efficacy of a single dose of cyclophosphamide.

J Int Med Res 2018 Nov 5:300060518800864. Epub 2018 Nov 5.

1 University Department Pro.Sa.M.I. "G. D'Alessandro", University of Palermo, Palermo, Italy.

A 9-year-old boy with petechiae on the legs and abdominal pain was unsuccessfully treated with steroids. He was admitted to our hospital for the onset of fever, ecchymosis, and arthralgia. Skin lesions suggested vasculitis, but they were not typical of Henoch-Schönlein purpura. Read More

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http://journals.sagepub.com/doi/10.1177/0300060518800864
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http://dx.doi.org/10.1177/0300060518800864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300931PMC
November 2018
7 Reads

A 19-year old man with IgA vasculitis after vaccination.

Braz J Infect Dis 2018 Sep - Oct;22(5):442-444. Epub 2018 Oct 30.

UTHealth - McGovern Medical School, Division of Infectious Diseases, Department of Internal Medicine, Houston, United States; UTHealth - McGovern Medical School, Center for Antimicrobial Resistance and Microbial Genomics (CARMiG) and Division of Infectious Diseases, Houston, United States; UTHealth - School of Public Health, Center for Infectious Diseases, Houston, United States; Universidad El Bosque, Centro Internacional de Genómica Microbiana, Unidad de Genética Molecular y Resistencia Antimicrobiana, Bogota, Colombia. Electronic address:

A 19-year-old patient who mistakenly received two doses of influenza vaccine 10 days before presentation, was admitted with malaise, weakness, and a purpuric non-blanching rash most prominent on the ankles followed by abdominal pain and hematochezia 72h later. The diagnosis of influenza vaccine-related Henoch-Schonlein vasculitis was made. This complication, although rare, is the most common vasculitis related to immunization. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14138670183056
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http://dx.doi.org/10.1016/j.bjid.2018.09.004DOI Listing
January 2019
17 Reads

Clinical significance of serum and mesangial galactose-deficient IgA1 in patients with IgA nephropathy.

PLoS One 2018 2;13(11):e0206865. Epub 2018 Nov 2.

Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.

Introduction: Galactose-deficient IgA1 (Gd-IgA1) is a critical pathogenic factor for IgA nephropathy (IgAN), but its value as a disease-specific biomarker remains controversial. We aimed to clarify the clinical significance of Gd-IgA1 in patients with IgAN.

Methods: We retrospectively reviewed 111 patients who were diagnosed with IgAN based on the findings of renal biopsies (RB) at Showa University Hospital since 2007. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206865PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214568PMC
November 2018
9 Reads

[Expression and significance of endothelial microparticles in children with Henoch-Schönlein purpura].

Zhongguo Dang Dai Er Ke Za Zhi 2018 Oct;20(10):831-834

Children's Hospital of Zhengzhou University/Children's Hospital of Henan Province/Zhengzhou Children's Hospital/Zhengzhou Children's Critical Medical Key Laboratory, Zhengzhou 450000, China.

Objective: To study the expression and significance of endothelial microparticles (EMPs) in children with Henoch-Schönlein purpura (HSP).

Methods: A total of 100 previously untreated children with HSP were classified to Henoch-Schönlein purpura nephritis (HSPN) group (n=40) and non-nephritis group (n=60). Thirty healthy children who underwent physical examination were enrolled as control group. Read More

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October 2018
1 Read

[Vasculitides and eosinophilic pulmonary diseases].

Z Rheumatol 2018 Dec;77(10):907-922

Abt. für Rheumatologie, Immunologie und Rehabilitation, Kantonsspital St. Gallen, St. Gallen, Schweiz.

Eosinophilic granulocytes form peripheral effector cells controlled by Th2 lymphocytes, which cause local cell, tissue, and functional disorders of infiltrated organs via the release of cytotoxic basic proteins and oxygen radicals. Diseases associated with eosinophilia include systemic and organ-related forms. The lungs are involved in eosinophilic granulomatosis with polyangiitis (EGPA, formerly known as Churg-Strauss syndrome), acute and chronic eosinophilic pneumonia, as well as in an organ manifestation in hypereosinophilic syndrome and certain parasitic diseases. Read More

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http://link.springer.com/10.1007/s00393-018-0561-z
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http://dx.doi.org/10.1007/s00393-018-0561-zDOI Listing
December 2018
14 Reads

Oral microbiota dysbiosis and its association with Henoch-Schönlein Purpura in children.

Int Immunopharmacol 2018 Dec 17;65:295-302. Epub 2018 Oct 17.

Shandong Children's Microbiome Center, Qilu Children's Hospital of Shandong University, Jinan 250022, China; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Chemistry and Environment, Beihang University, Beijing 100191, China; Qingdao Human Microbiome Center, The Affiliated Central Hospital of Qingdao University, Qingdao 266042, China. Electronic address:

Background: The pathogenesis of microbes in allergic diseases has been demonstrated and our previous research indicates that microbiota causing gut disorders in children is associated with Henoch-Schönlein Purpura. However, the role of oral microbiota in Henoch-Schönlein Purpura remains unknown.

Method: A total of 164 children were enrolled, of which 98 were patients with HSP and 66 were healthy children. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769183086
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http://dx.doi.org/10.1016/j.intimp.2018.10.017DOI Listing
December 2018
9 Reads
2.470 Impact Factor

Adult Onset Henoch-Schonlein Purpura associated with a Metastatic Malignancy of Unknown Primary Origin.

Hawaii J Med Public Health 2018 Oct;77(10):243-245

University of Hawai'i Internal Medicine Residency, Honolulu, HI (TP).

The cause of Henoch-Schonlein purpura, or IgA vasculitis, is largely unknown. It has been associated with infections, other rheumatologic triggers, and adverse drug reactions. Rarely, adult Henoch-Schonlein purpura is also associated with solid-tumor malignancies. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176269PMC
October 2018
10 Reads

Magnetic-Guided Capsule Endoscopy in the Diagnosis of Gastrointestinal Diseases in Minors.

Gastroenterol Res Pract 2018 18;2018:4248792. Epub 2018 Sep 18.

Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 197 Second Ruijin Road, Shanghai 200025, China.

Objective: This study aimed at investigating the clinical value of magnetic-guided capsule endoscopy (MGCE) in the diagnosis of gastrointestinal diseases in minors.

Methods: Eighty-four minor patients hospitalized in the pediatric department at Ruijin Hospital between June 2015 and January 2018 were enrolled for this study. Following bowel preparation, all patients underwent MGCE. Read More

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https://www.hindawi.com/journals/grp/2018/4248792/
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http://dx.doi.org/10.1155/2018/4248792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167592PMC
September 2018
12 Reads

[Role of Th17 Cells, Interleukin-17 and Matrix Metalloproteinase-13 in Pathogenesis of Henoch-Schonlein Purpura].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Oct;26(5):1502-1506

Department of Hematology, Chaohu Hospital of Anhui Medical University, Chaohu 238001, Anhui Province, China.E-mail: xhl1999cn

Objective: To explore the immunopathogenesis of Henoch-Schonlein purpara (HSP) by detecting the levels of Th17 cells, IL-17 and matrix metallo proteinase-13 (MMP-13) in peripheral blood and the expression of IL-17 in skin lesions at acate phase of HSP.

Methods: Th17 cell ratio in peripheral blood of HSP group and healthy control group was defected by flow cytometry, the plasma levels of IL-17 and MMP-13 in HSP group and healthy control group were defected by ELISA, and expression level of IL-17 in skin lesion of HSP group and skin tissue of healthy control group was deternined by: immunohistochemistry method.

Results: the ratio of Th17 cells in periphral blood of HSP group (1. Read More

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http://dx.doi.org/10.7534/j.issn.1009-2137.2018.05.041DOI Listing
October 2018