167,138 results match your criteria Hemostatic Disorders Nonplatelet


[Applying Chitosan-Modified Nanoemulsion in Nasal Vaccine Delivery].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Jul;52(4):592-597

Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

Objective: To prepare a chitosan-modified cationic nanoemulsion that could be used to prolong the residence time of nasal vaccines in the nasal cavity and improve the cellular uptake efficiency so as to enhance the immune efficacy of nasal vaccines.

Methods: A nanoemulsion-based vaccine coated with chitosan was prepared, and the particle size, potential, antigen encapsulation efficiency, stability as well as cytotoxicity were examined. The uptake efficiency of vaccine on different cells and the residence time of vaccine in the nasal cavity were measured. Read More

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An international multidisciplinary peer-driven consensus on the optimal use of hemostatic powders in surgical practice.

Updates Surg 2021 Jul 28. Epub 2021 Jul 28.

Department of General Surgery, S. Eugenio Hospital, Piazzale dell'Umanesimo, 10, 00144, Rome, Italy.

Bleeding is a consequence of insufficient hemostasis and excessive bleeding at a surgical site is associated with an increased risk of post-operative infection, transfusion and re-operation, in addition to increased hospital length of stay and costs. Surgeons employ a range of methods to achieve hemostasis, including topical hemostatic agents of differing composition and properties. Hemostatic powders are a sub-group of topical hemostats, which can be used in helping as adjuncts to manage troublesome bleeding in a variety of situations. Read More

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Editorial: Hemostatic Challenges in Pediatric Critical Care Medicine.

Front Pediatr 2021 12;9:697921. Epub 2021 Jul 12.

NHS Blood and Transplant; Oxford University Hospitals NHS Foundation Trust; Radcliffe Department of Medicine and Oxford BRC Haematology Theme, University of Oxford, Oxford, United Kingdom.

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Central Placenta Previa With Coexisting Central Cervical Fibroid in Pregnancy: An Obstetrician's Nightmare.

Cureus 2021 Jun 24;13(6):e15910. Epub 2021 Jun 24.

Obstetrics and Gynecology, Tata Main Hospital, Jamshedpur, IND.

Pregnancy with central placenta praevia and a coexistent cervical fibroid is infrequently encountered in clinical practice. A patient with this unusual combination is a nightmare for any clinician, especially if she presents with obstetric emergencies. In this scenario, there is a high chance of catastrophic obstetric hemorrhage during the peripartum period leading to a fatal outcome. Read More

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sp. nov., isolated from chromium-containing chemical plant soil.

Int J Syst Evol Microbiol 2021 Jul;71(7)

College of Biomass Science and Engineering, Sichuan University, Chengdu 610065, PR China.

A Gram-stain-positive, rod-shaped, aerobic, non-motile, non-sporulating bacterial strain, designated CSA1, was isolated from chromium-containing soil sampled at a chemical plant. Growth of strain CSA1 occurred at pH 6-10 (optimum, pH 7), 15-45 °C (optimum, 30 °C) and in the presence of 0.5-6. Read More

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sp. nov., an epiphytic bacterium isolated from rice root surfaces.

Int J Syst Evol Microbiol 2021 Jul;71(7)

Department of Biology, School of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand.

Two Gram-stain-negative, non-motile, rod-shaped bacterial strains were isolated from the surfaces of rice roots. They were designated as strains 1303 and 1310. Their colonies were circular, entire, opaque, convex and yellow. Read More

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[Application of tranexamic acid in the treatment of intertrochanteric fracture of femur].

Zhongguo Gu Shang 2021 Jul;34(7):601-4

Department of Orthopaedics, Hai'an People's Hospital, Nantong University, Nantong 226600, Jiangsu, China.

Objective: To investigate the application of tranexamic acid in the treatment of intertrochanteric fracture.

Methods: From January 2017 to October 2019, 100 patients with intertrochanteric fracture were randomly divided into observation group (48 cases) and control group(52 cases). All patients received the same surgical treatment. Read More

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sp. nov. and sp. nov., isolated from faeces of Tibetan antelope () and leaves of dandelion (), respectively, on the Qinghai-Tibet Plateau.

Int J Syst Evol Microbiol 2021 Jul;71(7)

Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi 030001, PR China.

In the present study, four bacterial strains, two (S-713 and 406) isolated from faecal samples of Tibetan antelopes and the other two (S-531 and 1598) from leaves of dandelion collected on the Qinghai-Tibet Plateau of PR China, were analysed using a polyphasic approach. All four isolates were aerobic, rod-shaped, non-motile, oxidase-negative, Gram-stain-positive and catalase-positive. According to four phylogenetic trees, strain pairs S-713/406 and S-531/1598 form two independent branches belonging to the genus , and are closest to , , , , and . Read More

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Polymer Network Editing of Elastomers for Robust Underwater Adhesion and Tough Bonding to Diverse Surfaces.

ACS Appl Mater Interfaces 2021 Jul 27. Epub 2021 Jul 27.

State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, 3th Section, South Renmin Road, Wuhou District, Chengdu 610041, China.

Tough adhesives with robust adhesion are desperately needed for biomedical and technological applications. However, it is extremely challenging to engineer tough and durable adhesives that are simple to make yet also exhibit strong underwater adhesion as well as tough bonding to diverse surfaces. Here, we report bioinspired elastomers based on water-immiscible polydiolcitrates, where their tough mechanical properties, robust underwater adhesion (80 kPa), and tough bonding performance (with an interfacial toughness >1000 J m and a shear and tensile strength >0. Read More

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Frequency and Risk Factors of Severe Postoperative Bleeding After Proctological Surgery: A Retrospective Case-Control Study.

Ann Coloproctol 2021 Jul 27. Epub 2021 Jul 27.

Proctologic Surgery, Groupe Hospitalier Diaconesses Croix Saint-Simon, Paris, France.

Purpose: The aim of this study was to assess frequency and risk factors of severe bleeding after proctological surgery requiring hemostatic surgery observed after publication of the French guidelines for anticoagulant and platelet-inhibitor treatment.

Methods: All patients who underwent proctological surgery between January 2012 and March 2017 in a referral center were included. Delay, severity of bleeding, and need for blood transfusion were recorded. Read More

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Recurrent Bleeding After Posthemorrhoidectomy Caused by Factor V Deficiency: A Case Report and Review of the Literature.

Ann Coloproctol 2021 Jul 27. Epub 2021 Jul 27.

Department of Surgery, Chonnam National University Medical School, Gwangju, Korea.

Congenital factor V (FV) deficiency is a rare hemorrhagic disorder that can cause excessive bleeding during and after surgery in the affected patient. This report is the case of a patient who had FV deficiency with recurrent posthemorrhoidectomy bleeding treated with the hemostatic procedure and fresh frozen plasma (FFP) transfusions. A 45-year-old male patient had previously undergone hemorrhoidectomy for multiple hemorrhoids at a local hospital. Read More

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FVIII at the crossroad of coagulation, bone and immune biology: emerging evidence of biological activities beyond hemostasis.

Drug Discov Today 2021 Jul 23. Epub 2021 Jul 23.

Université de Nantes, INSERM, Institut de Cancérologie de l'Ouest, Saint-Herblain 44805, France; University of Sheffield, Department of Oncology and Metabolism, Sheffield, UK. Electronic address:

Hemophilia A is an X-linked hereditary disorder that results from deficient coagulation factor VIII (FVIII) activity, leading to spontaneous bleeding episodes, particularly in joints and muscles. FVIII deficiency has been associated with altered bone remodeling, dysregulated macrophage polarization, and inflammatory processes that are associated with the neoformation of abnormal blood vessels. Treatment based on FVIII replacement can lead to the development of inhibitors that render FVIII concentrate infusion ineffective. Read More

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Highly Absorbent Silk Fibroin Protein Xerogel.

ACS Biomater Sci Eng 2021 Jul 26. Epub 2021 Jul 26.

National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, People's Republic of China.

Highly absorbent polymers have a wide range of applications in biomaterials, agriculture, physiological products of daily uses, and others. Silk fibroin, as a natural biomaterial with excellent biocompatibility and tunable mechanical properties, shows good prospects in the field of biomedicine applications. However, the dried fibroin hydrogel has very low absorbency. Read More

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[Study on the safety and effectiveness of low-dose tranexamic acid in operation of multi-level continuous thoracic ossification of ligament flavum].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Jul;35(7):873-877

Department of Orthopedics, Affiliated Hospital of North Sichuan Medical College, Nanchong Sichuan, 637000, P.R.China.

Objective: To investigate the safety and effectiveness of low-dose tranexamic acid (TXA) in operation of multi-level continuous thoracic ossification of ligament flavum (TOLF).

Methods: A clinical data of 26 patients who underwent operation for multi-level continuous TOLF and met the selection criteria between July 2015 and January 2019 was retrospectively analyzed. Among them, 13 cases (group A) were received intravenous infusion of TXA (10 mg/kg) at 15 minutes before operation, and maintained the infusion at 1 mg/(kg·h) until the end of the operation; 13 cases (group B) were received the same dose of normal saline before and during operation. Read More

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A break-even analysis of tranexamic acid for prevention of periprosthetic joint infection following total hip and knee arthroplasty.

J Orthop 2021 Jul-Aug;26:54-57. Epub 2021 Jul 13.

Tufts Medical Center, Boston, MA, USA.

Purpose: Despite the commonplace use of tranexamic acid in total joint arthroplasty, much of the current data regarding its cost-effectiveness examines savings directly related to its hemostatic properties, without considering its protective effect against periprosthetic joint infections. Using break-even economic modeling, we calculated the cost-effectiveness of routine tranexamic acid administration for infection prevention in total joint arthroplasty.

Materials And Methods: The cost of intraoperative intravenous tranexamic acid, the cost of revision arthroplasty for periprosthetic joint infections, and the baseline rates of periprosthetic joint infections in patients who did not receive intraoperative tranexamic acid were obtained from the literature and institutional purchasing records. Read More

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The traditional and modern uses of Selaginella tamariscina (P.Beauv.) Spring, in medicine and cosmetic: Applications and bioactive ingredients.

Authors:
Christian Bailly

J Ethnopharmacol 2021 Jul 21;280:114444. Epub 2021 Jul 21.

OncoWitan, Lille (Wasquehal), 59290, France. Electronic address:

Ethnopharmacological Relevance: Extracts of the plant Selaginella tamariscina (P.Beauv.) Spring (spike moss) are used for a long time in Asia, for the treatment of multiple diseases and conditions. Read More

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An Injectable Hybrid Gelatin Methacryloyl (GelMA)/Phenyl Isothiocyanate-Modified Gelatin (Gel-Phe) Bioadhesive for Oral/Dental Hemostasis Applications.

Polymers (Basel) 2021 Jul 20;13(14). Epub 2021 Jul 20.

Department of Chemical Engineering, Feng Chia University, Taichung 40724, Taiwan.

Biomaterials are widely used for effectively controlling bleeding in oral/dental surgical procedures. Here, gelatin methacryloyl (GelMA) was synthesized by grafting methacrylic anhydride on gelatin backbone, and phenyl isothiocyanate-modified gelatin (Gel-Phe) was synthesized by conjugating different gelatin/phenyl isothiocyanate molar ratios (G/P ratios) (i.e. Read More

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PAR2-Induced Tissue Factor Synthesis by Primary Cultures of Human Kidney Tubular Epithelial Cells Is Modified by Glucose Availability.

Int J Mol Sci 2021 Jul 14;22(14). Epub 2021 Jul 14.

Centre for Kidney Disease Research, Translational Research Institute, Faulty of Medicine, The University of Queensland at the Princess Alexandra, Brisbane, QLD 4072, Australia.

Coagulopathies common to patients with diabetes and chronic kidney disease (CKD) are not fully understood. Fibrin deposits in the kidney suggest the local presence of clotting factors including tissue factor (TF). In this study, we investigated the effect of glucose availability on the synthesis of TF by cultured human kidney tubular epithelial cells (HTECs) in response to activation of protease-activated receptor 2 (PAR2). Read More

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Factors Influencing the Antibacterial Activity of Chitosan and Chitosan Modified by Functionalization.

Int J Mol Sci 2021 Jul 12;22(14). Epub 2021 Jul 12.

University of Medicine and Pharmacy "Victor Babeș" Timișoara, 2 Piața Eftimie Murgu, 300041 Timișoara, Romania.

The biomedical and therapeutic importance of chitosan and chitosan derivatives is the subject of interdisciplinary research. In this analysis, we intended to consolidate some of the recent discoveries regarding the potential of chitosan and its derivatives to be used for biomedical and other purposes. Why chitosan? Because chitosan is a natural biopolymer that can be obtained from one of the most abundant polysaccharides in nature, which is chitin. Read More

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Acute monocyte pro inflammatory response predicts higher positive to negative acute phase reactants ratio and severe hemostatic derangement in dengue fever.

Cytokine 2021 Jul 20;146:155644. Epub 2021 Jul 20.

Department of Laboratory Services, GD Hospital and Diabetes Institute, 139A Lenin Sarani, Kolkata 700013, India.

Purpose: The present study was intended to investigate whether monocyte immune activation shapes plasma positive to negative acute phase reactants (APRs) ratio and predicts disease severity in dengue infection.

Methods: Serum level of ferritin, ceruloplasmin and transferrin was measured by means of electrochemiluminescence and immunoturbidimetry, respectively. Gene expression and plasma level for TNF-α, IL-6 and IL1-β was measured by means of RT-qPCR and ELISA. Read More

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sp. nov. and sp. nov., from marine sponges.

Int J Syst Evol Microbiol 2021 Jul;71(7)

College of Biological and Environmental Engineering, Changsha University, Changsha 410022, PR China.

Two novel strains, LHW50502 and LHW51113, were isolated from marine sponges obtained on Xisha Island, Hainan Province, PR China. Rods and cocci, typical characteristics of the genus , were observed. The strains contained -diaminopimelic acid as the diagnostic diamino acid in the cell-wall hydrolysates and galactose, arabinose, ribose and glucose as the whole-cell sugars. Read More

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gen. nov., sp. nov., within the new family fam. nov., and gen. nov., sp. nov., sp. nov., sp. nov. and sp. nov., belonging to the class .

Int J Syst Evol Microbiol 2021 Jul;71(7)

NAICONS Srl, Viale Ortles 22/4, 20139 Milano, Italy.

The aerobic, Gram-positive, mesophilic strains, Uno17, SOSP1-1, 1-9, 1-30 and 150040, formed mycelia of irregularly branched filaments, produced spores or sporangia, and numerous secondary metabolite biosynthetic gene clusters. The five strains grew at 15-40 °C (optimally at 30 °C) and pH 4.0-8. Read More

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sp. nov., an endophytic bacterium isolated from .

Int J Syst Evol Microbiol 2021 Jul;71(7)

Korean Collection for Type Cultures (KCTC), Biological Resource Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup 56212, Republic of Korea.

An aerobic, Gram-stain-negative, weak-motile, short-rod-shaped bacterial strain, designated JBR3-12, was isolated from halophyte plants, and its taxonomic position was investigated by using a polyphasic taxonomic approach. The strain produced a pink pigment on tryptic soy agar and grew optimally at 25 °C, pH 8 and in the presence of 3 % (w/v) NaCl. Results of phylogenetic analysis based on 16S rRNA gene sequences showed that strain JBR3-12 formed a lineage within the genus and was most closely related to DS-27 (98. Read More

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Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules.

Blood 2021 Jul 22. Epub 2021 Jul 22.

CHU de Quebec, Quebec, Quebec, Canada.

In addition to their hemostatic role, platelets play a significant role in immunity. Once activated, platelets release extracellular vesicles (EVs) formed by budding of their cytoplasmic membranes. Because of their heterogeneity, platelet EVs (PEVs) are thought to perform diverse functions. Read More

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Cryopreservation moderates the thrombogenicity of arterial allografts during storage.

PLoS One 2021 22;16(7):e0255114. Epub 2021 Jul 22.

Department of Vascular and Endovascular Surgery, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.

Introduction: Management of vascular infections represents a major challenge in vascular surgery. The use of cryopreserved vascular allografts could be a feasible therapeutic option, but the optimal conditions for their production and use are not precisely defined.

Aims: To evaluate the effects of cryopreservation and the duration of storage on the thrombogenicity of femoral artery allografts. Read More

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Role of lungs in the hemostasis system (review of literature).

Klin Lab Diagn 2021 Jul;66(7):411-416

Tashkent institute of postgraduate medical education.

The lung tissue contains various hemostatic system elements, which can be released from the lungs, both under physiological and pathological conditions. The COVID-19 pandemic has led to an increase in the number of patients with acute respiratory distress syndrome (ARDS) in intensive care units worldwide. When the lungs are damaged, coagulation disorders are mediated by tissue factor (TF) - factor VIIa (F VIIa), and inhibition of this pathway completely eliminates intrapulmonary fibrin deposition. Read More

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Saliva as new analytical object for D-dimer level determination.

Klin Lab Diagn 2021 Jul;66(7):407-410

A.I. Evdokimov Moscow State University of Medicine and Dentistry Ministry of Health of the Russian Federation.

The amount of D-dimer in the mixed saliva of healthy individuals and patients with comorbidities has been investigated. It has been established that the level of D-dimer in saliva increases with age regardless of pathology. The highest values were found in patients with erosive gastritis. Read More

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Pazopanib for severe bleeding and transfusion-dependent anemia in hereditary hemorrhagic telangiectasia.

Angiogenesis 2021 Jul 22. Epub 2021 Jul 22.

Division of Hematology, Massachusetts General Hospital, Zero Emerson Pl Suite 118, Office 112, Boston, MA, 02114, USA.

Hereditary hemorrhagic telangiectasia (HHT) is a rare angiogenic disorder causing chronic gastrointestinal bleeding, epistaxis, and severe anemia. Pazopanib is an oral multi-kinase angiogenesis inhibitor with promise to treat bleeding in HHT. We analyzed outcomes of HHT patients with the most severe bleeding causing RBC transfusion dependence treated on a predefined institutional pazopanib treatment pathway (with data collected retrospectively). Read More

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sp. nov., isolated from poultry feather waste.

Int J Syst Evol Microbiol 2021 Jul;71(7)

Department of Microbial, Biochemical and Food Biotechnology, University of the Free State, Bloemfontein, Free State, South Africa.

A Gram-stain-negative, rod-shaped, non-motile, non-spore-forming, aerobic, yellow-pigmented bacterium was isolated from chicken feather waste collected from an abattoir in Bloemfontein, South Africa. A polyphasic taxonomy study was used to describe and name the bacterial isolate, strain 1_F178. The 16S rRNA gene sequence analysis and sequence comparison data indicated that strain 1_F178 was a member of the genus and was closely related to (99. Read More

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