174,404 results match your criteria Hemostatic Disorders Nonplatelet

Tannic acid-crosslinked O-carboxymethyl chitosan hydrogels for enhanced antibacterial activity and rapid hemostasis.

J Biomater Sci Polym Ed 2022 Aug 11:1-15. Epub 2022 Aug 11.

College of Textiles and Clothing, Qingdao University, Qingdao 266061, Shandong, China.

Bacterial infection and massive blood loss are major challenges for global public health. Herein, a series of tannic acid encapsulated O-carboxymethyl chitosan (CMC) based hydrogels were prepared using a facile approach for both hemorrhage control and effective anti-bacterium. The results indicated that the tannic acid-cosslinked CMC hydrogels had excellent mechanical property, swelling ability as well as great cytocompatibility. Read More

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Fishing for answers to hemostatic and thrombotic disease: Genome editing in zebrafish.

Res Pract Thromb Haemost 2022 Jul 5;6(5):e12759. Epub 2022 Aug 5.

Department of Pediatrics University of Michigan School of Medicine Ann Arbor Michigan USA.

Over the past two decades, the teleost vertebrate (zebrafish) has emerged as a model for hemostasis and thrombosis. At genomic and functional levels, there is a high degree of conservation of the hemostatic system with that of mammals. Numerous features of the fish model offer unique advantages for investigating hemostasis and thrombosis. Read More

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Oxidative stress and the importance of eradication in patients with functional dyspepsia.

Saudi J Gastroenterol 2022 Aug 8. Epub 2022 Aug 8.

Deparment of Gastroenterology, Dicle University School of Medicine, Diyarbakır, Turkey.

Background: To investigage the thiol and disulphide levels in Helicobacter pylori-positive patients with non-ulcer dyspepsia and investigate the change in these levels with eradication therapy.

Methods: This is a prospective observational study. A total of 320 patients diagnosed with dyspepsia according to Rome IV criteria were included in the study. Read More

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Efficacy of topical hemostatic agents in malignancy-related gastrointestinal bleeding: a systematic review and meta-analysis.

Gastrointest Endosc 2022 Aug 6. Epub 2022 Aug 6.

Center for Advanced Therapeutic Endoscopy, Centura Health, Denver, CO, US. Electronic address:

Background And Aims: Despite advances in endoscopic therapies, malignancy-related gastrointestinal (GI) bleeding remains difficult to manage with high rates of treatment failure and rebleeding. Topical hemostatic agents (THA) are easier to apply to the wide bleeding surface of tumors. We conducted this systematic review and meta-analysis to evaluate the efficacy of THAs in malignancy-related GI bleed. Read More

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Novel blood derived hemostatic agents for bleeding therapy and prophylaxis.

Curr Opin Hematol 2022 Aug 4. Epub 2022 Aug 4.

Hoxworth Blood Center, University of Cincinnati Academic Health Center.

Purpose Of Review: Hemorrhage is a major cause of preventable death in trauma and cancer. Trauma induced coagulopathy and cancer-associated endotheliopathy remain major therapeutic challenges. Early, aggressive administration of blood-derived products with hypothesized increased clotting potency has been proposed. Read More

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D-dimer Thresholds to Exclude Pulmonary Embolism among COVID-19 Patients in the Emergency Department: Derivation with Independent Validation.

Clin Appl Thromb Hemost 2022 Jan-Dec;28:10760296221117997

Department of Emergency Medicine, 12267Wayne State University School of Medicine, Detroit, MI, USA.

Objective: To derive and validate a D-dimer cutoff for ruling out pulmonary embolism (PE) in COVID-19 patients presenting to the emergency department (ED).

Methods: A retrospective cohort study was performed in an integrated healthcare system including 22 adult ED's between March 1, 2020, and January 31, 2021. Results were validated among patients enrolled in the RECOVER Registry, representing data from 154 ED's from 26 US states. Read More

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Assessment of the antioxidant, antimicrobial and antibiofilm activities of essential oils for potential application of active chitosan films in food preservation.

World J Microbiol Biotechnol 2022 Aug 9;38(10):179. Epub 2022 Aug 9.

Université Clermont Auvergne, Clermont Auvergne INP, CNRS, Institut Pascal, 63000, Clermont-Ferrand, France.

In the food industry, the development of microbial biofilms is a serious problem that leads to the contamination and deterioration of food products. To overcome that, our aim consists of searching for natural antimicrobial and non-toxic compounds (essential oils EOs), which might be used alone or adsorbed on natural biopolymer films (chitosan). In this work, the antioxidant activity of eight EOs was evaluated by DPPH radical-scavenging method while their antibacterial activity was determined by diffusion on agar and microdilution methods. Read More

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Generation of cost-effective [email protected] chitosan nanofibrous wound dressing for promoting wound healing.

Biomater Adv 2022 Aug 1:213055. Epub 2022 Aug 1.

MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, PR China. Electronic address:

Herein, we designed and fabricated a [email protected] ([email protected])-decorated chitosan non-woven fabric (M-CNF) hemostatic dressing with super hydrophilic properties for wound repair and regeneration. The M-CNF exhibit excellently wettability characteristics which can rapidly absorb water from blood. Moreover, M-CNF with 15 mg/mL [email protected] (M-CNF-15) show better antibacterial performance, excellent blood-clotting performance, better blood cell and platelet adhesion ability than CNF, displaying both active and passive hemostatic mechanisms to accelerate blood clotting in mouse-liver injury model. Read More

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Balanced hemostatic resuscitation for bleeding pediatric trauma patients: A nationwide quantitative analysis of outcomes.

J Pediatr Surg 2022 Jul 15. Epub 2022 Jul 15.

Division of Trauma, Critical Care, Emergency Surgery, and Burns, Department of Surgery, College of Medicine, University of Arizona, 1501 N. Campbell Ave, Room 5411, P.O. Box 245063, Tucson, AZ 85724, USA. Electronic address:

Background: The administration of balanced component therapy has been associated with improvements in outcomes in adult trauma. There is little to no specific data to guide transfusion ratios in children. The aim of our study is to compare outcomes among different transfusion strategies in pediatric trauma patients. Read More

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Chitosan augments bioactive properties and drought resilience in drought-induced red kidney beans.

Food Res Int 2022 Sep 30;159:111597. Epub 2022 Jun 30.

Division of Plant Pathology, Faculty of Agriculture, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, Main Campus, Chatha, Jammu (J&K), India. Electronic address:

Application of 0.25% chitosan during seed priming or its foliage spray on Phaseolus vulgaris L. grown under restricted irrigations was assessed for its role in the enhancement of bioactive properties like antioxidant potential of dry seed. Read More

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September 2022

Antimicrobial activity of lactoferrin-chitosan-gellan nanoparticles and their influence on strawberry preservation.

Food Res Int 2022 Sep 27;159:111586. Epub 2022 Jun 27.

School of Food Engineering, University of Campinas - UNICAMP, Campinas - SP, Brazil. Electronic address:

Lactoferrin (L), chitosan (C) and gellan (G) nanoparticles were produced by electrostatic complexation, aiming to enhance the antimicrobial characteristics of these compounds. Binary complexes (lactoferrin-gellan and chitosan-gellan) and ternary complexes (lactoferrin-chitosan-gellan) were studied in eight different proportions of biopolymers. The antimicrobial activity of nanoparticles against S. Read More

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September 2022

Immature platelet fraction in rheumatoid arthritis with interstitial lung disease.

Reumatol Clin (Engl Ed) 2022 Aug-Sep;18(7):406-409

Aydin Adnan Menderes University Medical Faculty, Department of Rheumatology, Aydın, Turkey.

Background: Platelets have an effect on the hemostatic defense of the lung. Immature platelet fractions (iPF) reflects the number of young platelets containing ribonucleic acid in the circulation and real-time production. Information about their roles in rheumatic diseases is limited and there are no studies on iPF in RA with interstitial lung disease (ILD). Read More

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The Vexing Voyage of Vasopressin: The Consequences of Granting Market Exclusivity to Unapproved Drugs.

Chest 2022 Aug;162(2):433-435

Program On Regulation, Therapeutics, And Law (PORTAL), Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA. Electronic address:

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Surgical outcomes in people with hemophilia A taking emicizumab prophylaxis: experience from the HAVEN 1-4 studies.

Blood Adv 2022 Aug 8. Epub 2022 Aug 8.

Hospital Universitario La Paz, Madrid, Spain.

Many people with hemophilia A (PwHA) undergo surgery in their lifetime, often due to complications of their disease. Emicizumab is the first bispecific monoclonal antibody prophylactic therapy for PwHA, and its efficacy and safety have been previously demonstrated; however, there is a need to build an evidence base on the management of PwHA on emicizumab undergoing surgery. Data from the HAVEN 1-4 phase 3 clinical trials were pooled to provide a summary of all minor and major surgeries in PwHA with or without factor VIII inhibitors who were receiving emicizumab prophylaxis. Read More

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Platelets and tyrosine kinase inhibitors: clinical features, mechanism of action and effects on physiology.

Am J Physiol Cell Physiol 2022 Aug 8. Epub 2022 Aug 8.

Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, United States.

Tyrosine kinase inhibitors (TKIs) have emerged as a promising class of target-directed, small molecule inhibitors used to treat hematologic malignancies, inflammatory diseases, and autoimmune disorders. Recently, TKIs have also gained interest as potential antiplatelet-directed therapeutics that could be leveraged to reduce pathologic thrombus formation and atherothrombotic complications, while minimally affecting platelet hemostatic function. This review provides a mechanistic overview and summarizes the known effects of tyrosine kinase inhibitors on platelet signaling and function, detailing prominent platelet signaling pathways downstream of the glycoprotein VI (GPVI) receptor, integrin αβ, and G-protein couple receptors (GPCRs). Read More

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Mechanism of Enhanced Oral Absorption of a Nano-Drug Delivery System Loaded with Trimethyl Chitosan Derivatives.

Int J Nanomedicine 2022 29;17:3313-3324. Epub 2022 Jul 29.

College of Pharmacy, Guilin Medical University, Guilin, 541199, People's Republic of China.

Introduction: In the previous study, nanoparticles coated with trimethyl chitosan (TMC) derivatives (PPTT-NPs) could promote the oral bioavailability of panax notoginseng saponins (PNS). Herein, we chose PPTT-NPs as a model drug to study the property and mechanism of intestinal absorption in vitro and in vivo.

Methods: The stability of PPTT-NPs was evaluated using simulated gastric fluid and simulated intestinal fluid. Read More

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Meta-Analysis of the Efficacy and Safety of Tranexamic Acid in Spinal Surgery.

Comput Math Methods Med 2022 27;2022:9406497. Epub 2022 Jul 27.

Department of Spinal Surgery, Nanjing Lishui People's Hospital, Nanjing, Jiangsu Province, China.

Objective: The safety and effectiveness of topical tranexamic acid in spinal surgery has not yet been reached, and further research is needed to confirm it. This study is aimed at detecting the effectiveness and safety on the tranexamic acid in spinal surgery.

Methods: The Cochrane Library, PubMed, Embase, CNKI, and other databases were searched. Read More

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Effects of Vitamin C Combined with Growth Inhibitors on Gastrointestinal Bleeding in Cirrhosis.

Contrast Media Mol Imaging 2022 18;2022:5319786. Epub 2022 Jul 18.

Department of Gastroenterology, Xinchang County People's Hospital Affiliated to Wenzhou Medical University, Shaoxing, China.

The purpose of this study was to investigate the effect of vitamin C combined with growth inhibitors on serum miR-130a, nitric oxide (NO), and hemostasis in the treatment of upper gastrointestinal bleeding (UGIB) in cirrhosis. Eighty patients with cirrhosis UGIB treated in our hospital from March 2021 to March 2022 were selected and divided into two groups using the random number table method. The control group received growth inhibitor treatment, while the observation group was given vitamin C combined with growth inhibitor treatment for 3 d. Read More

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Antibacterial and Antibiofilm Potency of Menadione Against Multidrug-Resistant S. aureus.

Curr Microbiol 2022 Aug 8;79(9):282. Epub 2022 Aug 8.

Department of Microbiology, Savitribai Phule Pune University, Pune, 411007, Maharashtra, India.

Menadione is an analogue of 1,4-naphthoquinone (1,4-NQ) that possesses enormous pharmaceutical potential. The minimum inhibitory concentration (MIC) of menadione was determined against eighteen pathogens of the ESKAPE category, including thirteen multidrug-resistant (MDR) and five standard strains. From a total of eighteen pathogens, five strains of S. Read More

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Visualizing Endoscopy- Generated Aerosols with Laser Light Scattering.

Gastrointest Endosc 2022 Aug 3. Epub 2022 Aug 3.

Digestive Diseases Branch, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA. Electronic address:

Background & Aims: Upper gastrointestinal (GI) endoscopy is speculated to be an aerosol-generating procedure (AGP). Robust evidence exists for aerosol transmission of SARS-CoV-2. The quality of data available confirming aerosol generation during GI endoscopy is limited. Read More

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Efficacy and safety of fibrinogen concentrate for perioperative prophylaxis of bleeding in adult, adolescent, and pediatric patients with congenital fibrinogen deficiency: FORMA-02 and FORMA-04 clinical trials.

Transfusion 2022 Aug 6. Epub 2022 Aug 6.

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Milan, Italy.

Background: Congenital fibrinogen deficiency (CFD) is a rare coagulation disorder placing patients at increased bleeding risk. Human fibrinogen concentrate (HFC) represents current standard of care for fibrinogen replacement in CFD, however, limited data are available on HFC for prophylactic administration before/during surgery. Here, we report results and dosing considerations for HFC treatment in perioperative bleeding management in adult, adolescent, and pediatric patients with CFD. Read More

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RNA-Seq analysis reveals the important co-expressed genes associated with polyphyllin biosynthesis during the developmental stages of Paris polyphylla.

BMC Genomics 2022 Aug 5;23(Suppl 1):559. Epub 2022 Aug 5.

CAS Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming, 650223, Yunnan, China.

Background: Plants synthesize metabolites to adapt to a continuously changing environment. Metabolite biosynthesis often occurs in response to the tissue-specific combinatorial developmental cues that are transcriptionally regulated. Polyphyllins are the major bioactive components in Paris species that demonstrate hemostatic, anti-inflammatory and antitumor effects and have considerable market demands. Read More

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Efficacy of electrocoagulation hemostasis: a study on the optimal usage of the very-low-voltage mode.

Surg Endosc 2022 Aug 5. Epub 2022 Aug 5.

Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

Background: The very-low-voltage (VLV) mode in electrosurgery can stably and deeply energize tissues even if the local electrical resistance changes with energization. Therefore, in electrosurgical hemostasis, the VLV mode is more reliable than other coagulation modes. In clinical practice, the appropriate use of combined saline drip and blood suction under the VLV mode can further enhance coagulation ability. Read More

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Delayed Hemorrhage Followed by Vertebral Artery Injury during Cervical Anterior Controllable Antedisplacement and Fusion Surgery: Case Report and Literature Review.

Orthop Surg 2022 Aug 5. Epub 2022 Aug 5.

Department of Orthopaedics, Zhejiang Hospital, Hangzhou, China.

Background: Vertebral artery injury (VAI) during cervical spine surgery is rare. Anterior controllable ante-displacement and fusion (ACAF) surgery is a novel technique for treating degenerative cervical spine disorders, especially ossification of the posterior longitudinal ligament. To date, there have been no reports of VAI during cervical ACAF surgery. Read More

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Rapid fabrication of bionic pyrogallol-based self-adhesive hydrogel with mechanically tunable, self-healing, antibacterial, wound healing, and hemostatic properties.

Biomater Adv 2022 May 17;136:212765. Epub 2022 Mar 17.

College of Materials Engineering, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China; National Forestry & Grassland Administration Key Laboratory for Plant Fiber Functional Materials, Fuzhou 350108, PR China; Guangxi Key Laboratory of Clean Pulp & Papermaking and Pollution Control, College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, PR China. Electronic address:

Hydrogels are functional materials that are similar to human skin and have received much attention in recent years for biomedical applications. However, the preparation of nontoxic, highly adhesive, and antimicrobial hydrogels in an efficient way remains a great challenge. Inspired by adhesive mussel foot proteins (mfps) which consist of abundant catecholic amino acids and lysine (Lys) residues, gallic acid-modified ε-poly-L-lysine (EPL/GA) was synthesized, and an active functional monomer (AA-EPL/GA) was then created through a reaction with acrylic acid (AA). Read More

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Electrostatic self-assembly approach in the deposition of bio-functional chitosan-based layers enriched with caffeic acid on Ti-6Al-7Nb alloys by alternate immersion.

Biomater Adv 2022 May 4;136:212791. Epub 2022 Apr 4.

AGH University of Science and Technology, Faculty of Materials Science and Ceramics, A. Mickiewicza Av. 30, 30 059 Kraków, Poland. Electronic address:

Tailoring surface properties by layer-by-layer (LBL) deposition directed on the construction of complex multilayer coatings with nanoscale precision enables the development of novel structures and devices with desired functional properties (i.e., osseointegration, bactericidal activity, biocorrosion protection). Read More

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Expandable, biodegradable, bioactive quaternized gelatin sponges for rapidly controlling incompressible hemorrhage and promoting wound healing.

Biomater Adv 2022 May 29;136:212776. Epub 2022 Mar 29.

Department of Intensive Care, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325011, China. Electronic address:

Designing expandable sponges with biodegradability and effective antibacterial properties are the urgent challenge for incompressible hemorrhage and wound healing. In the present investigation, based on quaternized gelatin (QG) and oxidized dextran (OD), a series of expandable sponges (ODQG) with high-water absorption capacity and robust mechanical properties were prepared. ODQG had good biodegradability in vitro and in vivo, and had inherent antibacterial activity (90% for E. Read More

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In-situ formable dextran/chitosan-based hydrogels functionalized with collagen and EGF for diabetic wounds healing.

Biomater Adv 2022 May 25;136:212773. Epub 2022 Mar 25.

Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, PR China. Electronic address:

Delayed or non-healing skin wounds causing gangrene or even amputation, greatly threats diabetic patients lives. Herein, a bioactive, in-situ formable hydrogel based wound dressing was designed through simple Schiff base reaction. Oxidized dextran (OD) and carboxyethyl chitosan (CEC) were crosslinked together and applied as the main porous framework of hydrogel. Read More

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UiO-66 metal-organic framework as a double actor in chitosan scaffolds: Antibiotic carrier and osteogenesis promoter.

Biomater Adv 2022 May 18;136:212757. Epub 2022 Mar 18.

Erciyes University, Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, 38039 Kayseri, Turkey; Erciyes University Genome and Stem Cell Center, 38039 Kayseri, Turkey.

Metal-organic frameworks (MOFs) have recently emerged as a useful class of nanostructures with well-suited characteristics for drug delivery applications, due to the high surface area and pore size for efficient loading. Despite their use as a nano-carrier for controlled delivery of various types of drugs, the inherent osteo-conductive properties have stolen a great attention as a growing area of investigation. Here, we evaluated the double function of UiO-66 MOF structure as a carrier for fosfomycin antibiotic and also as an osteogenic differentiation promoter when introduced in 3D chitosan scaffolds, for the first time. Read More

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