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Turk Neurosurg 2018 Oct 17. Epub 2018 Oct 17.

Heinrich-Braun-Clinic.

Aim: In glioblastoma multiforme, the balance between the procoagulant system, anticoagulant system and fibrinolytic system is impaired in favour of hypercoagulability. The aim of this study was to compare glioblastoma multiforme with astrocytoma grade II by subjectively evaluating the levels of prothrombin and biotinylation thrombin, and G protein serum protease activatin receptors, as tissue factors causing hypercoagulation and affecting coagulation.

Material And Methods: Specimens from 35 cases with glioblastoma multiforme and 23 cases with astrocytoma grade II were evaluated immunohistochemically. Read More

Curr Urol Rep 2019 Jan 16;20(1). Epub 2019 Jan 16.

Servicio de Urología, Hospital General Universitario Gregorio Marañón, C/ Doctor Esquerdo, 46, 28007, Madrid, Spain.

Purpose Of Review: To provide the critical elements to effectively manage hemorrhage from vascular injuries sustained during planned urological interventions.

Recent Findings: The frequency of intraoperative vascular injuries is increasing. However, literature concerning the management of iatrogenic operative vascular injuries is scarce. Read More

PLoS One 2019 15;14(1):e0210963. Epub 2019 Jan 15.

Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

The formation of hemostatic plugs at sites of vascular injury crucially involves the multimeric glycoprotein von Willebrand factor (VWF). VWF multimers are linear chains of N-terminally linked dimers. The latter are formed from monomers via formation of the C-terminal disulfide bonds Cys2771-Cys2773', Cys2773-Cys2771', and Cys2811-Cys2811'. Read More

Clin Otolaryngol 2019 Jan 15. Epub 2019 Jan 15.

Department of Otolaryngology, Guy's and St Thomas' Hospital, London, SE1 9RT.

Hemopatch (HE) advanced hemostatic pad composed of collagen and a synthetic, protein-reactive monomer which polymerises on contact with protein containing body fluids such as blood and CSF to seal tissues. HE is readily available which shortens the operating time, and may be manipulated intra-nasally to reconstruct defects of the anterior skull base. Reconstruction using HE reduces the morbidity compared with traditional facia lata graft harvesting techniques. Read More

Med Devices (Auckl) 2019 27;12:1-7. Epub 2018 Dec 27.

Clinic of Gynecology, Obstetrics and Gynecological Oncology, University Hospital for Gynecology, Carl von Ossietzky University, Pius-Hospital Oldenburg, Oldenburg, Germany,

The evolution of minimally invasive surgery has brought forward the appearance of new advances in the course of the most recent couple of years and has introduced energy-based devices. The newest among them today are the ultrasonically activated devices, which are utilized with a great deal of components in-play, including ergonomics and financial aspects amid surgery. The methodology embraced was finding significant investigations through studies from PubMed, Medline and Google Scholar on current ultrasonic dissectors, which are Ethicon's Harmonic Scalpel (ACE), Covidien's Sonicision™ (SNC), Conmed's SonoSurg (SS) and Olympus's Thunderbeat, to describe their efficacy in terms of vessel sealing speed, vessel burst pressure, visibility, operation time and thermal speed. Read More

World J Gastroenterol 2019 Jan;25(1):69-84

Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8655, Japan.

Acute lower gastrointestinal bleeding (LGIB) is a common indication for hospital admission. Patients with LGIB often experience persistent or recurrent bleeding and require blood transfusions and interventions, such as colonoscopic, radiological, and surgical treatments. Appropriate decision-making is needed to initially manage acute LGIB, including emergency hospitalization, timing of colonoscopy, and medication use. Read More

Blood 2019 Jan 14. Epub 2019 Jan 14.

Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia.

Thrombosis with associated inflammation (thromboinflammation) occurs commonly in a broad range of human disorders. It is well recognized clinically in the context of superficial thrombophlebitis (thrombosis and inflammation of superficial veins), however it is more dangerous when it develops in the microvasculature of injured tissues and organs. Microvascular thrombosis with associated inflammation is well recognized in the context of sepsis and ischemia-reperfusion injury, however it also occurs in organ transplant rejection, major trauma, severe burns, the antiphospholipid syndrome, preeclampsia, sickle cell disease and biomaterial-induced thromboinflammation. Read More

World Neurosurg 2019 Jan 11. Epub 2019 Jan 11.

Department of Neurosurgery, New York University School of Medicine, NY, USA.

Background: Neurovascular training models include animal models, synthetics, or computer simulation. In vivo models are expensive and require significant resources. Synthetic/computer models do not reflect the elasticity of fresh vessels. Read More

Dermatol Surg 2019 Jan 11. Epub 2019 Jan 11.

Dermatology Service, Memorial Sloan Kettering Cancer Center, Hauppauge, New York.

Background: A diminished-staining artifact is observed in some Mohs frozen sections that are stained in toluidine blue (T-blue). Such an artifact, not yet described in the literature, may interfere with a Mohs surgeon's accurate reading. The authors hypothesize that topical hemostatic agents, aluminum chloride, and Monsel's solution are the causative factors. Read More

J Photochem Photobiol B 2018 Dec 5;191:135-142. Epub 2018 Dec 5.

Henan Joint International Research Laboratory of Drug Discovery of Small Molecules, Huanghe Science & Technology University, Zhengzhou 450063, PR China.

Natured botanical extract has attracted considerable attention recently in the field of skin anti-ultraviolet (UV) radiation. As a medicinal herb, Sophora japonica flower buds contained several components such as flavonoids, isoflavonoids, triterpenes, alkaloids and polysaccharides, which have multiple pharmacological properties except hemostatic agents which have been used in China and Korea for centuries. The purpose of our study was to investigate whether polysaccharide extracted from Sophora japonica L. Read More

Int J Biol Macromol 2019 Jan 9. Epub 2019 Jan 9.

Fujian Provincial Key Laboratory of Polymer Materials, College of Chemistry and Materials Science, Fujian Normal University, Fujian 350007, China. Electronic address:

Chitosan has been made into various hemostats, but their hemostatic efficiency for controlling severe traumatic bleeding is still inadequate. The aim of this work is to make quick hemostats by incorporating mesoporous silica nanoparticles into chitosan. Porous chitosan-silica composite microspheres (CSMS-S) with high hemostatic efficacy were fabricated through a combination of the microemulsion, thermally induced phase separation, and surfactant templating method. Read More

Transfus Apher Sci 2018 Dec 30. Epub 2018 Dec 30.

American Red Cross Holland Laboratory, Rockville, MD, USA. Electronic address:

Platelet transfusions are a life-saving medical intervention used for the treatment of thrombocytopenia or hemorrhage. Extensive research has gone into trying to understand how to store platelets prior to the transfusion event. Much has been learned about storage bag materials, synthetic solutions, and how temperature impacts platelet viability and function. Read More

Pancreatology 2019 Jan 2. Epub 2019 Jan 2.

Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. Electronic address:

Objective: The aim of this study was to evaluate the prognostic value of pre-treatment plasma hemostatic parameters in patients with advanced pancreatic cancer.

Methods: A total of 320 patients diagnosed with advanced pancreatic cancer between January 1, 2011 to December 31, 2015 were enrolled in this retrospective study. The prognostic significance of hemostatic parameters such as prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FBG), platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW) was determined by univariate and multivariate Cox hazard models. Read More

Rev Neurol 2019 Jan;68(2):89-90

Complejo Hospitalario Universitario de Vigo, Vigo, Espana.

Clin Transplant 2019 Jan 12:e13478. Epub 2019 Jan 12.

Department of Anesthesia and Pain Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.

Introduction: Thromboelastography (TEG) is gaining increasing acceptance in liver transplantation (LT) with conventional coagulation tests (CCTs) such as prothrombin time (PT), activated partial thromboplastin time (aPTT), antithrombin III (ATIII), platelet count (PLT) and fibrinogen concentration. The purpose of this study was to evaluate the clinical utility of TEG in LT, and investigate the correlation between TEG and CCT values during each phase of LT.

Materials And Methods: Medical records of patients who underwent deceased donor LT at a single, university hospital between October 2010 and July 2015 were retrospectively reviewed. Read More

Psychosom Med 2019 Jan 10. Epub 2019 Jan 10.

Albert Einstein College of Medicine, Bronx, NY.

Objective: We examined associations among socioeconomic adversity, social resources, and allostatic load in Hispanic/Latino youth, who are at high risk for obesity and related cardiometabolic risks.

Methods: Participants were N=1343 Hispanic/Latino youth (51% male; ages 8-16 years) offspring of Hispanic Community Health Study/Study of Latinos (HCHS/SOL) participants. Between 2012-2014, youth underwent a fasting blood draw and anthropometric assessment, and youth and their enrolled caregivers provided social and demographic information. Read More

Haematologica 2019 Jan 10. Epub 2019 Jan 10.

Linköping University, Linköping, Sweden.

As platelet activation is an irreversible and potentially harmful event, platelet stimulatory signaling must be tightly regulated to ensure the filtering-out of inconsequential fluctuations of agonist concentrations in the vascular milieu. Herein, we show that platelet activation via G protein-coupled receptors is gradient-dependent that is determined not only by agonist concentrations but also by how rapidly concentrations change over time. We demonstrate that gradient-dependent inhibition is a common feature of all major platelet stimulatory G protein-coupled receptors, while platelet activation via the non- G protein-coupled receptor glycoprotein VI is strictly concentration-dependent. Read More

BMC Anesthesiol 2019 Jan 10;19(1):10. Epub 2019 Jan 10.

Department of Pediatrics and Adolescent Medicine, University of Erlangen-Nurnberg, Loschgestr. 15, 91054, Erlangen, Germany.

Background: Hemorrhage and blood loss are still among the main causes of preventable death. Global hemostatic assays are useful point-of-care test (POCT) devices to rapidly detect cumulative effects of plasma factors and platelets on coagulation. Thromboelastography (TEG) and Thromboelastometry (ROTEM) are established methods in many anesthesiological departments for guided hemostatic treatment. Read More

Semin Thromb Hemost 2019 Jan 10. Epub 2019 Jan 10.

Department of Haematology and Transfusion Medicine, National Centre of Haemostasis and Thrombosis, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin University Hospital, Martin, Slovakia.

Since the identification of antithrombin deficiency by Egeberg in 1956, ongoing research in prothrombotic defects continues to progress. Interestingly, past research has predominantly focused on coagulation factors and not on other components of the hemostatic system. The possible role of platelet function defects in the development of thrombotic events was suggested for the first time in the late 1970s, when an increased platelet adhesiveness and aggregation after epinephrine (EPI) and adenosine diphosphate (ADP) was found in a group of patients with unexplained transient ischemic attack. Read More

Endoscopy 2019 Jan 10. Epub 2019 Jan 10.

Digestive Disease Center, Department of Internal Medicine, Inha University School of Medicine, Incheon, Republic of Korea.

Background:  A new hemostatic adhesive powder (UI-EWD) has been developed to reduce the high re-bleeding rates associated with the currently available hemostatic powders. The current study aimed to assess the efficacy of UI-EWD as a salvage therapy for the treatment of refractory upper gastrointestinal bleeding (UGIB).

Methods:  A total of 17 consecutive patients who had failed to achieve hemostasis with conventional endoscopic procedures and had undergone treatment with UI-EWD for endoscopic hemostasis in refractory UGIB were prospectively enrolled in the study. Read More

J Card Surg 2019 Jan 10;34(1):50-62. Epub 2019 Jan 10.

Advanced Powder Investigators Group (APIG).

Aims Of The Study: The safety and efficacy of a hemostatic powder (HP) versus a control agent, absorbable gelatin sponge and thrombin (G + T), were assessed, using a validated, quantitative bleeding severity scale.

Methods: Subjects were randomized to receive HP (256 subjects) or G + T (132 subjects) for treatment of minimal, mild, or moderate bleeding at 20 investigational sites. The primary efficacy endpoint was non-inferiority of HP relative to G + T for success at achieving hemostasis within 6 minutes. Read More

J Trauma Acute Care Surg 2019 Jan 8. Epub 2019 Jan 8.

Duke University School of Medicine, Duke University Department of Surgery, Duke University Department of Surgery, Duke University Department of Pediatrics, Duke University Department of Surgery, Duke University Department of Pathology, Duke University Department of Surgery,

Background: Pediatric patients require massive transfusion (MT) in a variety of settings. Multiple studies of adult MT support balanced ratio transfusion to improve outcomes, however it is unclear if these findings can be extrapolated to pediatric populations. The use of balanced transfusion ratios, MT protocols, hemostatic adjuncts, and even the definition of a MT in children are all open questions. Read More

Membranes (Basel) 2019 Jan 8;9(1). Epub 2019 Jan 8.

Agricultural Product Processing Research Institute, Chinese Academy of Tropical agricultural Sciences, Zhanjiang 524001, China.

In this study, the porous composite films of carboxymethyl chitosan/alginate/tranexamic acid were fabricated, with calcium chloride as the crosslinking agent and glycerin as a plasticizer. The composite films were characterized by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. The properties of the composite films, including water absorption, air permeability, and cumulative release rate, were tested. Read More

Gynecol Obstet Invest 2019 Jan 9:1-7. Epub 2019 Jan 9.

Background: We aimed to compare the hemostatic effect and perioperative outcomes between internal iliac artery (IIA) and abdominal aorta (AA) balloon occlusions in pernicious placenta previa patients complicated with placenta accrete and underwent cesarean delivery.

Methods: One hundred and twenty-three pernicious placenta previa patients complicated with placenta accrete were retrospectively reviewed. Patients who received IIA or AA occlusions were subsequently divided into the IIA group (n = 71) and AA group (n = 52). Read More

VideoGIE 2019 Jan 23;4(1):5-6. Epub 2018 Nov 23.

Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.

Toxins (Basel) 2019 Jan 7;11(1). Epub 2019 Jan 7.

Escola Superior de Ciências da Saúde, Universidade do Estado do Amazonas, Manaus 69065-001, Brazil.

snakebites usually present systemic bleeding, and the clinical⁻epidemiological and laboratorial factors associated with the development of this manifestation are not well established. In this study, we assessed the prevalence of snakebites with systemic bleeding reported at the , in Manaus, Amazonas State, Brazil, and the clinical⁻epidemiological and laboratorial factors associated with systemic bleeding. This is an observational, cross-sectional study carried out between August, 2013 and July, 2016. Read More

J Thromb Haemost 2019 Jan 7. Epub 2019 Jan 7.

Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

New evidence has stirred up a long-standing but undeservedly forgotten interest in the role of erythrocytes, or red blood cells (RBCs), in blood clotting and its disorders. This review summarizes the most recent research that describes the involvement of RBCs in hemostasis and thrombosis. There are both quantitative and qualitative changes in RBCs that affect bleeding and thrombosis, as well as interactions of RBCs with cellular and molecular components of the hemostatic system. Read More

Semin Hematol 2018 Apr 20;55(2):68-75. Epub 2018 Apr 20.

Department of Pediatrics, Division of Pediatric Hematology/Oncology, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY. Electronic address:

Sickle cell disease is an inherited hemoglobinopathy characterized by hemolytic anemia, frequent painful episodes, poor quality of life, end organ damage and a shortened lifespan. Although the seminal event is the polymerization of the abnormal hemoglobin, the downstream pathophysiology of vaso-occlusion results from heterotypic interactions between the altered, adhesive sickle cell RBCs, neutrophils, endothelium, and platelets. Ischemia reperfusion injury, hemolysis and oxidant damage all contribute to heightened inflammation and activation of the hemostatic system. Read More

J Int Med Res 2019 Jan 7:300060518817408. Epub 2019 Jan 7.

Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Korea.

Objective: To investigate the effect of ascorbic acid (AA) on hemostatic function during living donor liver transplantation (LDLT).

Methods: Blood samples from 21 LDLT recipients were taken within 30 minutes after induction and at 120 minutes after reperfusion. Rotational thromboelastography (TEG) and western blot analysis were used to analyze for fibrinolysis and functional changes in c-Cbl and Cbl-b, respectively. Read More

Gastrointest Endosc 2018 Oct 26. Epub 2018 Oct 26.

Division of Gastroenterology, Royal Alexandra Hospital, Edmonton, Alberta, Canada.

Background And Aims: Acute lower GI bleeding is a frequent cause of hospital admission. The objective of this study was to evaluate the safety and performance of a hemostatic powder (TC-325/Hemospray) in the treatment of nonvariceal lower GI bleeding.

Methods: Patients were enrolled into this prospective, multicenter, single-arm study at 4 tertiary care centers in Canada. Read More

J Oral Maxillofac Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiology, Corlu Government Hospital, Tekirdag, Turkey.

Purpose: Direct oral anticoagulants (DOACs) have many advantages over warfarin regarding periprocedural management for dental extractions. They avoid the need to assess and possibly adjust warfarin therapy to achieve appropriate hemostatic status before and after extraction. The present study evaluated the real-life data regarding quality of life (QoL) and burden for patients with atrial fibrillation receiving long-term treatment with warfarin or DOACs during periprocedural management for dental extraction. Read More

Oral Maxillofac Surg 2019 Jan 4. Epub 2019 Jan 4.

Department of Molecular and Cell Biology, Institute of Biology, Fluminense Federal University, Niterói, RJ, Brazil.

J Orthop Surg Res 2019 Jan 4;14(1). Epub 2019 Jan 4.

Tianjin Institute of Orthopedics in Traditional Chinese and Western Medicine, Tianjin Hospital, NO.155 Munan Road, Tianjin, 300050, China.

Background: It is unclear which kind of interventional therapy is the best when reducing blood loss in patients prepared for total hip arthroplasty (THA). We performed this network meta-analysis to rank the best intervention arm for blood loss control in THA patients.

Methods: We searched electronic databases about randomized controlled trials (RCTs) to compare three treatments (topical tranexamic acid (TXA), intravenous TXA, and topical fibrin sealant (FS)) versus placebo for the people prepared for THA. Read More

Biomater Sci 2019 Jan 4. Epub 2019 Jan 4.

Joint Department of Biomedical Engineering, North Carolina State University and The University of North Carolina at Chapel Hill, Raleigh, NC 27695, USA. and Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27695, USA.

Native platelets perform several critical functions within the context of wound healing, including participating in initial hemostasis and interacting with fibrin at the wound site to induce clot retraction. Platelet depletion or dysfunction due to trauma or disease can inhibit robust wound healing responses. There has been a focus recently on developing synthetic, non-immunogenic platelet mimetic technologies for the purpose of augmenting hemostatic responses in cases of deficient native platelet functionality. Read More

Ann Biomed Eng 2019 Jan 3. Epub 2019 Jan 3.

Department of Biomedical Engineering, University of Texas, 107 W. Dean Keaton, BME 3.503D, 1 University Station, C0800, Austin, TX, 78712, USA.

Despite advances in the development of materials for cardiovascular devices, current strategies generally lack the thromboresistance of the native endothelium both in terms of efficacy and longevity. To harness this innate hemostatic regulation and improve long-term hemocompatibility, biohybrid devices are designed to promote endothelialization. Much of the research effort to date has focused on the use of extracellular matrix (ECM)-mimics and coatings to promote endothelial cell adhesion and migration with less attention given to the effect of the supported ECM binding events on hemostatic regulation. Read More

Oral Maxillofac Surg 2019 Jan 3. Epub 2019 Jan 3.

Department of Periodontics and Implantology, SDM College of Dental Sciences and Hospital, Sattur, Dharwad, Karnataka, 580009, India.

Arch Gynecol Obstet 2019 Jan 4. Epub 2019 Jan 4.

Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Giza, Egypt.

Purpose: To evaluate the effect of a modified type II radical hysterectomy on maternal morbidities and mortality in cases with abnormally invasive placenta (AIP).

Methods: 63 cases with AIP were managed at one of the largest referral centers in Egypt in a prospective study design. This technique entails devascularization of the uterus laterally on both sides and to clamp the uterus at the lowest possible point just below the level of the placenta while sparing the ureters. Read More

Langenbecks Arch Surg 2019 Jan 3. Epub 2019 Jan 3.

Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

Background: Several modalities exist for the management of hepatic neoplasms. Resection, the most effective approach, carries significant risk of hemorrhage. Blood loss may be corrected with red blood cell transfusion (RBCT) in the short term, but may ultimately contribute to negative outcomes. Read More

Pol J Vet Sci 2018 Dec;21(4):769-778

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Selcuk University, 42003, Konya, Turkey.

Disseminated intravascular coagulation (DIC) is a complex, dynamic and hemostatic disorder which develops secondarily to a disease characterized with an imbalance in the pro-coagulant and anti-coagulant components of hemostasis. The aim of the study is to evaluate hemostatic dysfunc- tion and the DIC syndrome in cattle with displaced abomasum (DA), with using the hematologic analyses and an extensive coagulation profile in the 96 hour-period including before and after surgery. The animal material of the study consisted of 12 dairy cows diagnosed with displaced abomasum (9 LDA and 3 RDA without volvulus) in the 2-4 week period after parturation and with no other post-partum disease. Read More

Int J Hematol 2019 Jan 2. Epub 2019 Jan 2.

Kitakyushu Yahata-Higashi Hospital, Kitakyusyu, Japan.

Rurioctocog alfa (recombinant factor VIII: Advate) is available for the control of bleeding in patients with hemophilia A in Japan. To evaluate the inhibitor development, safety, and efficacy of rurioctocog alfa, a non-interventional and observational postmarketing surveillance was conducted on 352 previously treated Japanese patients aged 1-76 years with ≥ 4 exposure days under the conditions of routine clinical practice. A post-hoc comparison of the mean annualized bleeding rates which required treatment with rurioctocog alfa detected a statistically significant difference (P < 0. Read More

Carbohydr Polym 2019 Mar 26;207:180-190. Epub 2018 Oct 26.

MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China.

Tissue adhesion is one of the most common complications after surgery (especially after abdominal surgery), causing notable influences after the damaged tissue has healed. A physical barrier placed between the wound site and the adjacent tissues is a convenient and highly effective technique to minimize or prevent abdominal adhesions. In this work, the N, O-carboxymethyl chitosan/oxidized regenerated cellulose (N, O-CS/ORC) composite gauze was prepared. Read More

Acta Biomater 2018 Dec 29. Epub 2018 Dec 29.

Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin 300071, China. Electronic address:

Wound dressings with multiple functions are required to meet the complexity of the wound healing process. The multifunctionality often leads to an increase in the complexity and difficulty in dressing preparation. To surmount this problem, we used a facile preparation and fabrication process to fabricate a multi-functional dressing by integrating four widely accessible materials: plain gauze, sodium alginate (SA), Ca and Co. Read More

Biomed Res Int 2018 25;2018:7020539. Epub 2018 Nov 25.

Royal Canadian Medical Services, Ottawa, Ontario, and McGill University, Montreal, Quebec, Canada.

Fibrinogen is crucial for the formation of blood clot and clinical outcomes in major bleeding. Both Thromboelastography (TEG) and Rotational Thromboelastometry (ROTEM) have been increasingly used to diagnose fibrinogen deficiency and guide fibrinogen transfusion in trauma and surgical bleeding patients. We conducted a comprehensive and comparative review on the technologies and clinical applications of two typical functional fibrinogen assays using TEG (FF TEG) and ROTEM (FIBTEM) for assessment of fibrinogen level and deficiency, and prediction of transfusion requirement. Read More

Vet Immunol Immunopathol 2019 Jan 24;207:36-45. Epub 2018 Nov 24.

Biology Department, Biosciences Institute, São Paulo State University (UNESP), Avenida 24 A, 1515, 13506-900 Rio Claro, SP, Brazil. Electronic address:

Rhipicephalus sanguineus s. l. is popularly known as the "brown dog tick" since dogs are its preferential hosts, but the species has been reported to parasitize other mammals, including humans, with significant medical-veterinary importance since it transmits several important pathogenic agents during the feeding period. Read More

Zhongguo Zhong Yao Za Zhi 2018 Nov;43(22):4397-4403

Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Science, Wuhan 430074, China.

The plants of Bletilla are one of the groups in Orchidaceae with the highest economic value. As the traditional Chinese medicinal material, Bletillae Rhizoma exhibits excellent efficacy in hemostatic, antibiosis, detumescent, anticancer activities and regenerating tissue to heal wound, which has great development potential. However, Bletillae Rhizoma is mainly collected from wild resources. Read More

Anticancer Res 2019 Jan;39(1):113-118

Department of Surgery, Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada

Background/aim: Desmopressin is a synthetic analogue of the antidiuretic hormone vasopressin. It has recently been demonstrated to inhibit tumor progression and metastasis in breast cancer models. Docetaxel is a chemotherapy agent for castrate-resistant prostate cancer (CRPC). Read More

Anticancer Res 2019 Jan;39(1):17-23

Division of Colorectal Surgery, Department of Surgery, Drexel University, Philadelphia, PA, U.S.A.

The incidence of anal squamous cell carcinoma (ASCC) in the U.S. is increasing, particularly in immunocompromised patients. Read More

Ann Biol Clin (Paris) 2018 Dec 27. Epub 2018 Dec 27.

Service d'hématologie biologique, CHU Pontchaillou, Rennes, France, CIC-Inserm 1414, Université de Rennes 1, France.

Many neutralizing agents of anticoagulant effect of factor Xa or thrombin inhibitors (xabans and dabigatran, respectively) have been developed since the commercialization of direct oral anticoagulants (DOAC) in 2008. Idarucizumab is a specific antidote of dabigatran commercialised since 2016. An antidote of xabans, andexanet-α, was very recently approved by the Food and Drug Administration (FDA). Read More

Arterioscler Thromb Vasc Biol 2019 Jan;39(1):5-6

From the BloodCenter of Wisconsin-Versiti, Milwaukee.

Vet Clin Pathol 2018 Dec;47(4):560-574

Department of Veterinary Clinical Sciences, University of Copenhagen, Frederiksberg, Denmark.

Background: Staphylococcus aureus is an opportunistic pathogen with the ability to form mobile planktonic aggregates during growth, in vitro. The in vivo pathophysiologic effects of S aureus aggregates on host responses are unknown. Knowledge of these could aid in combating infections. Read More