159,565 results match your criteria Hemostatic Disorders Nonplatelet


Bleeding characteristics and management of minor surgeries in rare bleeding disorders: report from a Turkish Pediatric Hematology Center.

Turk J Pediatr 2020 ;62(4):584-593

Division of Pediatric Hematology, Department of Pediatric, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.

Background And Objectives: In this retrospective report the aim was to present the experience about bleeding characteristics and management of minor surgeries in rare bleeding disorders (RBDs).

Methods: Twenty-six patients were included; with Factor (F) V, FV+VIII, VII, FXI deficiency and afibrinogenemia. Six of the patients were asymptomatic. Read More

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http://dx.doi.org/10.24953/turkjped.2020.04.008DOI Listing
January 2020

Innate immune receptors in platelets and platelet-leukocyte interactions.

J Leukoc Biol 2020 Aug 10. Epub 2020 Aug 10.

Laboratory of Immunothrombosis, Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil.

Platelets are chief cells in hemostasis. Apart from their hemostatic roles, platelets are major inflammatory effector cells that can influence both innate and adaptive immune responses. Activated platelets have thromboinflammatory functions linking hemostatic and immune responses in several physiological and pathological conditions. Read More

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http://dx.doi.org/10.1002/JLB.4MR0620-701RDOI Listing

Characterization, antibiofilm and biocompatibility properties of chitosan hydrogels loaded with silver nanoparticles and ampicillin: an alternative protection to central venous catheters.

Colloids Surf B Biointerfaces 2020 Jul 29;196:111292. Epub 2020 Jul 29.

Posgrado en Ciencias Farmacobiológicas, Facultad de Ciencias Químicas (FCQ), Universidad Autónoma de San Luis Potosí (UASLP), Av. Dr. Manuel Nava No. 6 Zona Universitaria, CP 78210, San Luis Potosí, S.L.P., Mexico; Centro de Investigación en Ciencias de la Salud y Biomedicina, UASLP, Sierra Leona No. 550, Lomas, CP 28210, San Luis Potosí, S.L.P., Mexico. Electronic address:

The purpose of this study was to generate novel chitosan hydrogels (CHs) loaded with silver nanoparticles (AgNPs) and ampicillin (AMP) to prevent early formation of biofilms. AgNPs and CHs were characterized by UV-Vis, DLS, TEM, rheology, FT-IR, Raman, and SEM. The antibiofilm effect of the formulations was investigated against four multidrug-resistant and extensively drug-resistant pathogens using a colony biofilm, a high cell density and gradients model. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.111292DOI Listing

A polymer-based systemic hemostatic agent.

Sci Adv 2020 Jul 31;6(31):eaba0588. Epub 2020 Jul 31.

John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

Uncontrolled noncompressible hemorrhage is a major cause of mortality following traumatic injuries in civilian and military populations. An injectable hemostat for point-of-care treatment of noncompressible hemorrhage represents an urgent medical need. Here, we describe an injectable hemostatic agent via polymer peptide interfusion (HAPPI), a hyaluronic acid conjugate with a collagen-binding peptide and a von Willebrand factor-binding peptide. Read More

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http://dx.doi.org/10.1126/sciadv.aba0588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394519PMC

Dieulafoy Lesion: Predictive Factors of Early Relapse and Long-Term Follow-Up.

GE Port J Gastroenterol 2020 Jul 17;27(4):237-243. Epub 2020 Jan 17.

Gastroenterology Department, Coimbra Hospital and Universitary Centre, E.P.E., Coimbra, Portugal.

Introduction: The Dieulafoy lesion (DL) is a rare cause of gastrointestinal bleeding. Advances in the endoscopy field have allowed an increased rate of detection and therapeutic efficacy. However, doubts remain about the most effective hemostatic approach, the affecting variables of therapeutic failure, and early relapse, as well as in the long-term follow-up. Read More

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http://dx.doi.org/10.1159/000504720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383276PMC

Domestic donkey bite of genitalia: an unusual etiology of penile glans amputation in Burkina Faso (case report and literature review).

Pan Afr Med J 2020 12;36:13. Epub 2020 May 12.

Division of Urology, Souro Sanou University Teaching Hospital, Bobo-Dioulasso, Burkina Faso.

A 15-years-old boy was admitted in our hospital emergency unit with complaints of injured and hemorrhagic penile glans after donkey bites. The accident occurred during domestic activity with the animal when the boy attempted to guide the donkey. After thorough physical examination, the patient presented a penile glans amputation. Read More

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http://dx.doi.org/10.11604/pamj.2020.36.13.20620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388611PMC

Predictors of surgical management of high grade blunt splenic injuries in adult trauma patients: a 5-year retrospective cohort study from an academic level I trauma center.

Patient Saf Surg 2020 3;14:32. Epub 2020 Aug 3.

Department of Traumasurgery, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands.

Backgrounds: Splenic injury accounts for 40% of all injuries after blunt abdominal trauma. Blunt splenic injury in hemodynamically unstable patients is preferably treated by splenectomy. Nowadays hemodynamically stable patients with low grade splenic injuries are mostly treated by non-operative management (NOM). Read More

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http://dx.doi.org/10.1186/s13037-020-00257-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398213PMC

Thromboembolic events and Covid-19.

Adv Biol Regul 2020 Aug 17;77:100735. Epub 2020 Jun 17.

Inserm U1048 and Université Toulouse III Paul Sabatier, I2MC, 31024, Toulouse Cedex 03, France; Laboratoire d'Hématologie, CHU de Toulouse, 31059, Toulouse, France. Electronic address:

The novel Corona virus infection (Covid-19) first identified in China in December 2019 has rapidly progressed in pandemic leading to significant mortality and unprecedented challenge for healthcare systems. Although the clinical spectrum of Covid-19 is variable, acute respiratory failure and systemic coagulopathy are common in severe Covid-19 patients. Lung is an important target of the SARS-CoV-2 virus causing eventually acute respiratory distress syndrome associated to a thromboinflammatory state. Read More

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http://dx.doi.org/10.1016/j.jbior.2020.100735DOI Listing

Magnesium and Risk of Bleeding Complications From Ventriculostomy Insertion.

Stroke 2020 Aug 10:STROKEAHA120030128. Epub 2020 Aug 10.

Department of Neurology (M.B.M., A.B., A.M.N., E.M.L.), Northwestern University, Chicago, IL.

Background And Purpose: Hemorrhages are a serious complication of brain surgery, and magnesium has shown hemostatic properties in hemorrhagic stroke and non-neurological surgeries. External ventricular drain (EVD) insertion is an advantageous model of emergency neurosurgical hemorrhage risk because it is common, standardized, and the operator is blinded to the outcome during the procedure. We tested the hypothesis that low magnesium is associated with risk of hemorrhagic complications from EVD insertion. Read More

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http://dx.doi.org/10.1161/STROKEAHA.120.030128DOI Listing

VWF/ADAMTS13 imbalance, but not global coagulation or fibrinolysis, is associated with outcome and bleeding in acute liver failure.

Hepatology 2020 Aug 7. Epub 2020 Aug 7.

Surgical Research Laboratory, Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Background And Aims: Recent studies of acute liver failure (ALF) in man and animals have suggested that rebalanced hemostasis occurs, with distinct hypercoagulable features clinically evidenced by a low risk of bleeding. Rodent models have shown a link between intrahepatic microthrombus formation and progression of ALF. We sought to confirm these earlier findings in a large series of well-characterized ALF patients from the Acute Liver Failure Study Group (ALFSG). Read More

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http://dx.doi.org/10.1002/hep.31507DOI Listing

Emicizumab for the treatment of acquired hemophilia A.

Blood 2020 Aug 7. Epub 2020 Aug 7.

Dept. of. Int.Med.I, Div.of Hematology, Vienna, Austria.

Acquired hemophilia A (AHA) is a severe bleeding disorder caused by inhibiting autoantibodies to coagulation factor VIII (FVIII). For hemostatic treatment, bypassing agents, human or porcine FVIII are currently standard of care. Emicizumab is a bispecific, FVIII-mimetic therapeutic antibody, that reduced the annualized bleeding rates in congenital hemophiliacs. Read More

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http://dx.doi.org/10.1182/blood.2020006315DOI Listing

Thromboelastography maximum amplitude predicts short-term mortality in patients with hepatitis B virus-related acute-on-chronic liver failure.

Exp Ther Med 2020 Sep 13;20(3):2657-2664. Epub 2020 Jul 13.

Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, Zhejiang 315010, P.R. China.

Patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) exhibit complex hemostatic defects. Thromboelastography (TEG) can be used to reveal global hemostasis in patients with liver disease; however, little is known about the association between TEG and the outcome of patients with HBV-related ACLF. The present study aimed to investigate the value of TEG for predicting 90 day mortality in patients with HBV-related ACLF. Read More

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http://dx.doi.org/10.3892/etm.2020.8990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401745PMC
September 2020

Platelet Count within the Normal Range at Hospital Admission is Associated with Mortality in Patients with Community-Acquired Pneumonia.

Clin Epidemiol 2020 7;12:711-716. Epub 2020 Jul 7.

Department of Clinical Epidemiology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.

Background: Apart from their hemostatic role, platelets are immune cells that play a role in fighting infections. The presence of thrombocytopenia and thrombocytosis at hospital admission are predictors of mortality in community-acquired pneumonia patients. We hypothesized that variations in platelet counts within the normal range also may be associated with mortality in these patients. Read More

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http://dx.doi.org/10.2147/CLEP.S245067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369307PMC

Central Venous Catheter Insertion in Colorectal Cancer Patients, PICC or PC?

Cancer Manag Res 2020 14;12:5813-5818. Epub 2020 Jul 14.

Center of Oncology, Jiangsu Province Hospital, Nanjing, People's Republic of China.

Purpose: Central venous catheters (CVCs) have been demonstrated as a feasible method for chemotherapy delivery in colorectal cancer patients. The objective of our study was to explore the preference of colorectal cancer patients (89%) in our institution for port catheters (PCs) through comparing the costs and complications between peripherally inserted central venous catheters (PICCs) and PCs.

Methods: Overall, 777 colorectal cancer patients (89%) were eligible for central venous catheter (CVC) insertions from January 1, 2017, to January 1, 2019. Read More

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http://dx.doi.org/10.2147/CMAR.S250410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368562PMC

Ankaferd hemostat (ABS) as a potential mucosal topical agent for the management of COVID-19 syndrome based on its PAR-1 inhibitory effect and oestrogen content.

Med Hypotheses 2020 Jul 31;143:110150. Epub 2020 Jul 31.

Department of Hematology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

COVID-19 due to the SARS-CoV-2 infection is a multi-systemic immune syndrome affecting mainly the lungs, oropharyngeal region, and other vascular endothelial beds. There are tremendous ongoing efforts for the aim of developing drugs against the COVID-19 syndrome-associated inflammation. However, currently no specific medicine is present for the absolute pharmacological cure of COVID-19 mucositis. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.110150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392953PMC

Factor Xa and thrombin induce endothelial progenitor cell activation. The effect of direct oral anticoagulants.

Platelets 2020 Aug 7:1-8. Epub 2020 Aug 7.

Atherothrombosis Research Centre/Laboratory of Biochemistry, Department of Chemistry, University of Ioannina , Ioannina, Greece.

Factor Xa (FXa) and thrombin exert non-hemostatic cellular actions primarily mediated through protease-activated receptors (PARs). We investigated the effect of FXa and thrombin on human late-outgrowth endothelial cells (OECs), a type of endothelial progenitor cells (EPCs), and on human umbilical vein endothelial cells (HUVECs). The effect of direct oral anticoagulants (DOACs), rivaroxaban and dabigatran, was also studied. Read More

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http://dx.doi.org/10.1080/09537104.2020.1802413DOI Listing

Use of thromboelastography to monitor effects of the hemocoagulase on the blood coagulation in patients after thoracic surgery.

Ann Palliat Med 2020 Jul;9(4):2090-2095

Department of Blood Transfusion, The First Affiliated Hospital of Soochow University, Suzhou, China.

Background: Over the past few years, snake venom thrombin-like preparations which possess the advantages of low toxicity, fast onset, and long-lasting efficacy have been commonly used as hemostatic drugs in clinical surgery. However, recently, cases of hypofibrinogenemia and bleeding after using the hemocoagulase have been reported and cannot be ignored. Our study used thromboelastography (TEG) to monitor the hemocoagulase effects of blood coagulation status in patients after thoracic surgery. Read More

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http://dx.doi.org/10.21037/apm-20-1221DOI Listing

[Acquired factor V inhibitor].

Rinsho Ketsueki 2020 ;61(7):791-798

Department of Hematology, Kanazawa University Hospital.

Since acquired factor V inhibitor (FV-INH) has been first reported in Germany in 1955, about 200 cases have been recorded globally. The incidence of FV-INH is extremely low, with a rate of 0.023-0. Read More

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http://dx.doi.org/10.11406/rinketsu.61.791DOI Listing
January 2020

[Acquired hemophilia A].

Authors:
Tazuko Tokugawa

Rinsho Ketsueki 2020 ;61(7):785-790

Division of Hematology, Hyogo College of Medicine.

Acquired hemophilia A (AHA) is a bleeding disorder due to the autoantibody (inhibitor) production targeting blood coagulation factor VIII. It is characterized by a sudden onset, and it often causes extensive and severe bleeding in soft tissue. The incidence of AHA is 1. Read More

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http://dx.doi.org/10.11406/rinketsu.61.785DOI Listing
January 2020

"Gas Embolism after Hydrogen Peroxide Use during Spine Surgery: A Case Report and Literature Review".

World Neurosurg 2020 Aug 3. Epub 2020 Aug 3.

Department of Spine surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China. Electronic address:

Background: As an irrigant, an antiseptic and a hemostatic agent, hydrogen peroxide (HO) is widely used in surgical treatment, but it has been surrounded by persistent controversy. Fatal or near-fatal embolic events caused by HO have been reported sporadically in spine surgery.

Case Description: In this report, we present an 87-year-old man who underwent lumbar instrumentation removal and debridement consequent to surgical site infection (SSI) in a prone position. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.07.210DOI Listing

Elucidation of the active ingredients of against hemorrhage based on network pharmacology and tail snipping model in mice.

Pharmazie 2020 Aug;75(8):381-384

College of Pharmaceutical Sciences and Chinese Medicine, Southwest University, Chongqing; ; Email:

This study aimed to elucidate the active ingredients of (LH), the overground part of (Benth.) Kudo, against hemorrhage based on network pharmacology and tail snipping model in mice. A total of 118 hemorrhage-related target genes were identified by retrieving public databases, and 39 genes were identified as the hub genes of hemorrhage based on protein-protein interaction and module analyses. Read More

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http://dx.doi.org/10.1691/ph.2020.0507DOI Listing

Incidence of Bleeding and Thrombosis in Patients with Liver Disease.

Semin Thromb Hemost 2020 Aug 5. Epub 2020 Aug 5.

Liver Intensive Therapy Unit, Institute of Liver Studies, King's College Hospital, London, United Kingdom.

Historically, liver disease has been associated with a bleeding tendency. Global hemostatic assays have demonstrated that hemostasis is overall rebalanced, in both acute liver failure and chronic liver disease. It is now recognized that many bleeding events in chronic liver disease are mediated by portal hypertension rather than an underlying hemostatic defect. Read More

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http://dx.doi.org/10.1055/s-0040-1714205DOI Listing

Anticoagulant Management and Synthesis of Hemostatic Proteins during Machine Preservation of Livers for Transplantation.

Semin Thromb Hemost 2020 Aug 5. Epub 2020 Aug 5.

Section of HPB Surgery and Liver Transplantation, Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Liver transplantation remains the only curative treatment for patients with end-stage liver disease. Despite a steadily increasing demand for suitable donor livers, the current pool of donor organs fails to meet this demand. To resolve this discrepancy, livers traditionally considered to be of suboptimal quality and function are increasingly utilized. Read More

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http://dx.doi.org/10.1055/s-0040-1715452DOI Listing

Prognostic value of repeated thromboelastography measurement for favorable neurologic outcome during targeted temperature management in out-of-hospital cardiac arrest survivors.

Resuscitation 2020 Aug 2. Epub 2020 Aug 2.

Department of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. Electronic address:

Background: Cardiac arrest can activate blood coagulation, which clinically manifests as obstruction of the microcirculation and multiple organ dysfunction. Thromboelastography (TEG) provides a rapid and comprehensive assessment of hemostatic processes, but there are limited data on the use of sequential TEG values during targeted temperature management (TTM) in out-of-hospital cardiac arrest (OHCA) survivors. The aim of this study was to investigate the prognostic value of coagulopathy assessed by repeated TEG to predict neurologically intact survival. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2020.07.019DOI Listing

Continuous production of uniform chitosan beads as hemostatic dressings by a facile flow injection method.

J Mater Chem B 2020 Aug 4. Epub 2020 Aug 4.

Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, Virginia 23219, USA. and Department of Pharmaceutics, Virginia Commonwealth University, Richmond, Virginia 23298, USA and Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298, USA.

In this work, we developed a facile flow injection method to fabricate chitosan beads of uniform size in a continuous manner and assessed their properties as hemostatic dressings. Chitosan was dissolved into the ionic liquid 1-ethyl-3-methylimidazolium acetate (EMIM Ac) to form a solution, and then the chitosan/EMIM Ac solution was flow injected into ethanol to form beads of uniform size. The formed chitosan beads were obtained following the exchange of ethanol solvent with water and freeze-drying. Read More

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http://dx.doi.org/10.1039/d0tb01462aDOI Listing

Results of a randomised controlled trial between an ORC collagen hemostatic agent and a carrier-bound fibrin sealant.

J Visc Surg 2020 Jul 31. Epub 2020 Jul 31.

Department of Oral and Maxillofacial Surgery/Plastic Surgery, University Medicine Greifswald, Walther-Rathenau Str. 42a, 17475 Greifswald, Germany. Electronic address:

Introduction: Despite ongoing optimisation of surgical techniques, hemostasis continues to be a fundamental challenge in many operations today. This randomised controlled trial compared the efficacy of a new hemostatic agent made of oxidised regenerated cellulose and collagen (ORC-Coll) with that of a conventional carrier-bound fibrin sealant (CBFS).

Methods: Hemostasis was investigated representatively in the case of post-thyroidectomy bleeding from the resection surface. Read More

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http://dx.doi.org/10.1016/j.jviscsurg.2020.06.015DOI Listing

Laboratory features of severe vs. non-severe COVID-19 patients in Asian populations: a systematic review and meta-analysis.

Eur J Med Res 2020 Aug 3;25(1):30. Epub 2020 Aug 3.

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Background: More severe cases of COVID- 19 are more likely to be hospitalized and around one-fifth, needing ICU admission. Understanding the common laboratory features of COVID-19 in more severe cases versus non-severe patients could be quite useful for clinicians and might help to predict the model of disease progression. This systematic review and meta-analysis aimed to compare the laboratory test findings in severe vs. Read More

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http://dx.doi.org/10.1186/s40001-020-00432-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396942PMC

Nationwide analysis of whole blood hemostatic resuscitation in civilian trauma.

J Trauma Acute Care Surg 2020 Aug;89(2):329-335

From the Division of Trauma, Critical Care, Emergency Surgery, and Burns, Department of Surgery, College of Medicine, University of Arizona, Tucson, Arizona.

Introduction: Renewed interest in whole blood (WB) resuscitation in civilians has emerged following its military use. There is a paucity of data on its role in civilians where balanced component therapy (CT) resuscitation is the standard of care. The aim of this study was to assess nationwide outcomes of using WB as an adjunct to CT versus CT alone in resuscitating civilian trauma patients. Read More

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http://dx.doi.org/10.1097/TA.0000000000002753DOI Listing

Management of delayed bleeding after endoscopic mucosal resection of large colorectal polyps: a retrospective multi-center cohort study.

Endosc Int Open 2020 Aug 21;8(8):E1052-E1060. Epub 2020 Jul 21.

Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands.

 Delayed bleeding (DB) is the most frequent major adverse event after endoscopic mucosal resection (EMR) of large non-pedunculated colorectal polyps (LNPCPs). Evidence-based guidelines for management of DB are lacking. We aimed to evaluate the clinical presentation, treatment and outcome of patients with DB and to determine factors associated with hemostatic therapy. Read More

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http://dx.doi.org/10.1055/a-1192-3816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373661PMC

COVID-19, neutrophil extracellular traps and vascular complications in obstetric practice.

J Perinat Med 2020 Aug 3. Epub 2020 Aug 3.

Department of Obstetrics and Gynecology, I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

An issue of the novel coronavirus infection spreading is currently in the first place among others in the list of the international medical community. Due to lack of information, conflicting research findings, multicomponent effect of the virus on the body host, as well as various consequences that the virus triggers in the body, now every medical specialty does study the viral attack pathogenesis. Recent months showed that vascular complications are the most severe in the Coronavirus Disease 2019 (COVID-19) and are the main cause of death in the patients. Read More

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http://dx.doi.org/10.1515/jpm-2020-0280DOI Listing

Thromboelastography for prediction of hemorrhagic transformation in patients with acute ischemic stroke.

Am J Emerg Med 2020 May 23;38(9):1772-1777. Epub 2020 May 23.

Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea; Department of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. Electronic address:

Background: Thromboelastography (TEG) provides a rapid assessment of the hemostatic processes of a patient in emergency settings. There are limited data on TEG as a predictive tool for hemorrhagic transformation in patients with acute ischemic stroke. We investigated whether TEG values on admission could predict hemorrhagic transformation in patients with acute ischemic stroke. Read More

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http://dx.doi.org/10.1016/j.ajem.2020.05.052DOI Listing

Evaluation of Oral Factor Xa inhibitor-associated Extracranial Bleeding Reversal with Andexanet alfa.

J Thromb Haemost 2020 Aug 1. Epub 2020 Aug 1.

Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, Massachusetts, USA.

Introduction: A reversal agent for factor Xa (FXa) inhibitors, andexanet alfa, was FDA approved without extensive study of clinical effectiveness, due to an overwhelming demand for FXa inhibitor reversal. In this study, we aimed to describe patient selection, clinical effectiveness, and safety of FXa inhibitor reversal with andexanet alfa in patients presenting with extracranial bleeding.

Methods: Consecutive patients who received andexanet alfa for reversal of FXa inhibitor-associated extracranial hemorrhage were identified. Read More

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http://dx.doi.org/10.1111/jth.15031DOI Listing

Advances in the management of coagulopathy in acute promyelocytic leukemia.

Thromb Res 2020 Jul;191 Suppl 1:S63-S67

Hospital Universitario y Politécnico La Fe, Valencia, Spain.

Since the introduction of all-trans retinoic acid and, more recently, arsenic trioxide into the therapy of acute promyelocytic leukemia (APL), significant improvements in patient outcomes have been achieved, and this disease has become the most curable subtype of acute myeloid leukemia. However, while primary leukemia resistance has virtually disappeared, a sizable fraction of APL patients still die before or during induction therapy. Hemorrhagic death still remains the major problem during this early phase of treatment and, to a lesser extent, deaths due to infection, differentiation syndrome and other causes. Read More

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http://dx.doi.org/10.1016/S0049-3848(20)30399-6DOI Listing

Hemostatic biomarkers in occult cancer and cancer risk prediction.

Thromb Res 2020 Jul;191 Suppl 1:S37-S42

Department of Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy; University of Milan Bicocca, School of Medicine, Italy.

Cancer patients present with abnormalities of coagulation tests, reflecting a hypercoagulable state, often asso- ciated with a high incidence of thrombotic complications and poor disease prognosis. Different degrees of blood clotting abnormalities are described in diverse cancers, depending on tumor types and stage. The mechanisms of hemostasis that are critically involved in thrombosis are also implicated in tumor progression, angiogenesis, and metastatic spread. Read More

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http://dx.doi.org/10.1016/S0049-3848(20)30395-9DOI Listing

Cancer-associated thrombosis in pediatric patients.

Thromb Res 2020 Jul;191 Suppl 1:S22-S25

The Israeli National Hemophilia Center and Thrombosis Unit and Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer, Israel; Sackler School of Medicine, Tel Aviv University, Israel. Electronic address:

Childhood malignancy and especially acute lymphoblastic leukemia are increasingly associated with thromboembolism. The etiology of pediatric cancer associated thrombosis is multifactorial and may reflect a tumor mass effect, tumor thrombi, alterations of the hemostatic system, treatment-related hazards (e.g. Read More

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http://dx.doi.org/10.1016/S0049-3848(20)30392-3DOI Listing

The thrombin-inflammation axis in cancer progression.

Thromb Res 2020 Jul;191 Suppl 1:S117-S122

Cancer and Blood Diseases Institute, The Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address:

The last half century of cancer research has seen an explosion in our understanding of the complex interplay between cancer cells and host-derived factors critical for cancer progression. Two important host-derived arms that are part of this complex interplay are the inflammatory immune compartment and the hemostatic system. Chronic pathological inflammation is a major factor in the development of multiple common malignancies, including adenocarcinomas of the colon, pancreas, prostate and breast. Read More

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http://dx.doi.org/10.1016/S0049-3848(20)30408-4DOI Listing

Coagulation signaling and cancer immunotherapy.

Thromb Res 2020 Jul;191 Suppl 1:S106-S111

Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Mainz, Germany.

The last decades have delineated many interactions of the hemostatic system with cancer cells that are pivotal for cancer-associated thrombosis, angiogenesis and metastasis. Expanding evidence shows that platelets, the tissue factor pathway, and proteolytic signaling involving protease-activated receptors (PARs) are also central players in innate and adaptive immunity. Recent studies in immune-competent mice have uncovered new immune-evasive roles of coagulation signaling networks in the development and growth of different preclinical tumor models. Read More

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http://dx.doi.org/10.1016/S0049-3848(20)30406-0DOI Listing

[Blood-saving technologies in extensive liver resections].

Khirurgiia (Mosk) 2020 (7):111-118

Petrovsky Russian Research Center of Surgery, Moscow, Russia.

The researches devoted to blood-saving technologies in extensive liver resections are analyzed in the manuscript. Resection of three and more liver segments is effective method of surgical treatment of various focal liver lesions. Surgical (anatomical resection with hilar glissonean access, Pringle maneuver, modern technical equipment, etc. Read More

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http://dx.doi.org/10.17116/hirurgia2020071111DOI Listing
January 2020

Surgiflo may have a potential impact on the healing process in cricotracheal resection anastomosis.

Clin Otolaryngol 2020 Jul 31. Epub 2020 Jul 31.

Department of Otorhinolaryngology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Objectives: To evaluate the role of thrombin based hemostatic agent Surgiflo® (Ethicon, Somerville, USA) in improving the outcome of cricotracheal resection anastomosis.

Design: Randomized controlled clinical trial.

Setting: Otorhinolaryngology Department, Mansoura University Hospitals, Egypt. Read More

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http://dx.doi.org/10.1111/coa.13614DOI Listing

The Roles of GRKs in Hemostasis and Thrombosis.

Int J Mol Sci 2020 Jul 28;21(15). Epub 2020 Jul 28.

Cardeza Foundation for Hematologic Research, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Along with cancer, cardiovascular and cerebrovascular diseases remain by far the most common causes of death. Heart attacks and strokes are diseases in which platelets play a role, through activation on ruptured plaques and subsequent thrombus formation. Most platelet agonists activate platelets via G protein-coupled receptors (GPCRs), which make these receptors ideal targets for many antiplatelet drugs. Read More

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http://dx.doi.org/10.3390/ijms21155345DOI Listing

Platelet Dysfunction Diseases and Conditions: Clinical Implications and Considerations.

Adv Ther 2020 Jul 29. Epub 2020 Jul 29.

Department of Anesthesiology, LSU Health Shreveport, Shreveport, LA, USA.

Introduction: Platelet diseases and dysfunction are taught early in medical school to all future physicians. Understanding of the coagulation cascade and hemostatic mechanisms has allowed for targeted pharmacological therapies that have been significantly impactful in clinical practice. Platelets are an early participant in hemostasis physiologically and under pathophysiological states. Read More

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http://dx.doi.org/10.1007/s12325-020-01453-4DOI Listing

Wireless Ultrasound Surgical System with Enhanced Power and Amplitude Performances.

Sensors (Basel) 2020 Jul 27;20(15). Epub 2020 Jul 27.

Department of Medical IT Convergence Engineering, Kumoh National Institute of Technology, 350-27 Gumi-daero, Gumi 39253, Korea.

A wireless ultrasound surgical system (WUSS) with battery modules requires efficient power consumption with appropriate cutting effects during surgical operations. Effective cutting performances of the ultrasound transducer (UT) should be produced for ultrasound surgical knives for effective hemostasis performance and efficient dissection time. Therefore, we implemented a custom-made UT with piezoelectric material and re-poling process, which is applied to enhance the battery power consumption and output amplitude performances of the WUSS. Read More

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http://dx.doi.org/10.3390/s20154165DOI Listing

Can We Measure the Individual Prothrombotic or Prohemorrhagic Tendency by Global Coagulation Tests?

Hamostaseologie 2020 Aug 29;40(3):364-378. Epub 2020 Jul 29.

Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Bonn, Germany.

Hemostasis is a complex process in which abnormalities can cause shifts toward prothrombotic or prohemorrhagic states resulting in thrombosis or bleeding, respectively. Several coagulation tests may be required to characterize these defects but may yet not always reflect a patient's true hemostatic capacity. Thus, global coagulation tests aiming to simulate the coagulation process in vitro instead of measuring single components thereof are certainly of interest to assess prothrombotic or prohemorrhagic tendencies. Read More

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http://dx.doi.org/10.1055/a-1153-5824DOI Listing

Understanding and Preventing Placenta-Mediated Pregnancy Complications.

Hamostaseologie 2020 Aug 29;40(3):356-363. Epub 2020 Jul 29.

Department of Haematology, School of Medicine, University College Dublin, Rotunda Hospital and Mater University Hospital, Irish Network for VTE Research (INViTE), Dublin, Ireland.

Placenta-mediated pregnancy complications are clinically important conditions and include preeclampsia, placental abruption, intrauterine growth restriction, and late fetal loss. Pathophysiology is complex, and may be linked to prothrombotic disorders such as antiphospholipid syndrome, whose understanding is still evolving. In this narrative review, we will present the latest evidence to better understand hemostatic mechanisms of preeclampsia, as well as in women with placenta-mediated pregnancy complications and inherited thrombophilia or antiphospholipid antibodies. Read More

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http://dx.doi.org/10.1055/a-1184-8388DOI Listing

Predictors of Mortality in Adults Admitted with COVID-19: Retrospective Cohort Study from New York City.

West J Emerg Med 2020 Jul 8;21(4):779-784. Epub 2020 Jul 8.

BronxCare Health System, Department of Medicine, Affiliated with Icahn School of Medicine at Mount Sinai, Bronx, New York.

Introduction: Rapid spread of coronavirus disease 2019 (COVID-19) in the United States, especially in New York City (NYC), led to a tremendous increase in hospitalizations and mortality. There is very limited data available that associates outcomes during hospitalization in patients with COVID-19.

Methods: In this retrospective cohort study, we reviewed the health records of patients with COVID-19 who were admitted from March 9-April 9, 2020, to a community hospital in NYC. Read More

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http://dx.doi.org/10.5811/westjem.2020.6.47919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390589PMC

[Effect of Xingnaojing Injection in treatment of cerebral hemorrhage based on Tabu search algorithm:a real world study].

Zhongguo Zhong Yao Za Zhi 2020 Jul;45(14):3316-3323

School of Statistics, Renmin University of China Beijing 100872, China.

In this study, Tabu search algorithm was used to analyze the effect of Xingnaojing Injection in the treatment of cerebral hemorrhage in the real world. Through the analysis of the results, the therapies based on the pathogeny of cerebral hemorrhage were screened out: Xingnaojing Injection+hemostatic drugs for promoting blood circulation and removing stasis. Cerebral hemorrhage complicated with brain edema: combined with mannitol or mannitol+aescin. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200314.502DOI Listing

[Complex network analysis of combination medication of patients with kidney malignant tumor based in real world].

Zhongguo Zhong Yao Za Zhi 2020 Jul;45(14):3299-3306

Navy PLA General Hospital Beijing 100048, China.

Kidney malignant tumor is a type of primary renal cell carcinoma, and mainly refers to renal cancer. The incidence of kidney cancer and the number of hospital cases in China have been increasing. Based on the clinical medicine information of patients in the hospital information system(HIS) database of 37 hospitals in China, the combined medication of patients with kidney malignant tumor were analyzed by Tabu search algorithm, so as to analyze the combined medication of patients with kidney malignant tumor in real world. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200314.501DOI Listing

Bipolar-current needle-knife with a water jet function (Jet B-knife) shortens the procedure time of endoscopic submucosal dissection for colorectal tumors.

Surg Endosc 2020 Jul 28. Epub 2020 Jul 28.

Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan.

Background: Endoscopic submucosal dissection (ESD) is a technically difficult and time-consuming procedure for the treatment of large colorectal tumors. In Japan, the ball-tip bipolar-current needle-knife (BB-knife) has been used in ESD as a safe device that minimizes the damage to deeper tissues of colorectal neoplasms. In May 2012, a BB-knife combined with a water jet function (Jet B-knife) was newly developed. Read More

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http://dx.doi.org/10.1007/s00464-020-07832-wDOI Listing

To Clot or Not: HELLP Syndrome and Disseminated Intravascular Coagulation in an Eclamptic Patient with Intrauterine Fetal Demise.

Case Rep Anesthesiol 2020 7;2020:9642438. Epub 2020 Jul 7.

Department of Anesthesiology and Perioperative Medicine, Penn State Health Milton S. Hershey Medical Center, 500 University Dr., Mailcode H187, Hershey, PA 17033, USA.

A 39-year-old G2P1001 female presented from an outside hospital following an eclamptic seizure in the setting of HELLP syndrome. This condition was complicated by intrauterine fetal demise and disseminated intravascular coagulation, which required an emergent cesarean section. We report the work-up and intraoperative and postoperative management of this complex patient with multiple medical needs. Read More

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http://dx.doi.org/10.1155/2020/9642438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364204PMC

Should we pursue high obliteration rate or high hemostatic rate in the therapy of gastric varices?

Authors:
Gin-Ho Lo

Endoscopy 2020 Aug 28;52(8):709. Epub 2020 Jul 28.

Department of Medical Research, E-DA Hospital, School of Medicine for International Students, I-Shou University, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1055/a-1167-8274DOI Listing