151,936 results match your criteria Hemostatic Disorders Nonplatelet


Expanding Hydrophobically Modified Chitosan Foam for Internal Surgical Hemostasis: Safety Evaluation in a Murine Model.

J Surg Res 2019 Mar 15;239:269-277. Epub 2019 Mar 15.

Regenerative Bioscience Center, University of Georgia, Athens, Georgia. Electronic address:

Background: A novel injectable expanding foam based on hydrophobically modified chitosan (HM-CS) was developed to improve hemostasis during surgeries. HM-CS is an amphiphilic derivative of the natural biopolymer chitosan (CS); HM-CS has been shown to improve the natural hemostatic characteristics of CS, but its internal safety has not been systematically evaluated. The goal of this study was to compare the long-term in vivo safety of HM-CS relative to a commonly used fibrin sealant (FS), TISSEEL (Baxter). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jss.2019.01.060DOI Listing

Clotting factor activity in fresh frozen plasma after thawing with a new radio wave thawing device.

Transfusion 2019 Mar 18. Epub 2019 Mar 18.

Department of Transfusion Medicine and Hemostaseology, University Hospital Erlangen, Friedrich-Alexander-University, Erlangen, Germany.

Background: Massive hemorrhage usually results in rapid need of blood products. Patients in need of fresh frozen plasma (FFP) might benefit from shorter thawing times using a novel radio wave device. So far, only one study on the prototype has been published. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/trf.15246DOI Listing

Effects of cerium oxide nanoparticles on hemostasis: coagulation, platelets and vascular endothelial cells.

J Biomed Mater Res A 2019 Mar 18. Epub 2019 Mar 18.

Center of MicroBioRobotics @SSSA, Fondazione Istituto Italiano di Tecnologia, Viale Rinaldo piaggio 34, 56025 Pontedera (Pisa), Italy.

Cerium oxide nanoparticles (nanoceria, NC) have attracted much attention in biomedicine due to their surface composition that confers interesting redox activities and regenerative properties. Studies have demonstrated that the application of nanoparticles in biomedicine can influence components of hemostatic system, inducing blood clotting, alterations of blood cells, and endothelial cell functions. NC were tested in vitro to assess their hemocompatibility and anti-coagulant, anti-inflammatory and anti-senescence activity in human endothelial cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36669DOI Listing

Initial prospective study of ambulatory mPCNL on upper urinary tract calculi.

Urol J 2019 Mar 18. Epub 2019 Mar 18.

Department of Urology, Guizhou Provincial People's Hospital, Guiyang, Guizhou, P.R.China.

Objective: To explore the feasibility and safety of ambulatory mPCNL (mini percutaneous nephrolithotomy) on upper urinary tract calculi.

Methods: Clinical data of 18 patients received ambulatory mPCNL during Aug. 2017 to Jan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.22037/uj.v0i0.4828DOI Listing

Significant Hyperfibrinolysis in a Patient With Intracardiac Thrombosis: To Give Antifibrinolytics or Not?

Transplant Direct 2019 Mar 22;5(3):e431. Epub 2019 Feb 22.

Department of Anesthesiology, University of Wisconsin Hospitals and Clinics, Madison, WI.

The hemostatic system is a delicate balance between the coagulation, anticoagulation, and fibrinolytic systems and is responsible for preventing both hemorrhage and thrombosis. End stage liver disease is characterized by a rebalanced hemostatic system that is fragile and easily tipped towards either hemorrhage or thrombosis. During an orthotopic liver transplantation, patients are exposed to a wide variety of factors that can shift them from a hypercoagulable state to a hypocoagulable state almost instantaneously. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TXD.0000000000000875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411226PMC

Anesthesia management of arthroscopic ankle arthrodesis for a hemophilia patient after living-donor liver transplantation.

Intractable Rare Dis Res 2019 Feb;8(1):56-59

Department of Anesthesia, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Hemophilia is an X-linked recessive inherited coagulation disorder. We report the anesthesia management of a hemophilia patient who underwent arthroscopic ankle arthrodesis after living-donor liver transplantation due to cirrhosis. The 35-year-old male patient with hemophilia B was diagnosed with cirrhosis due to hepatitis C virus at the age of 23 years and underwent biologically-related partial liver transplantation at the age of 29 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5582/irdr.2018.01127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409122PMC
February 2019

Drug-release system of microchannel transport used in minimally invasive surgery for hemostasis.

Drug Des Devel Ther 2019 12;13:881-896. Epub 2019 Mar 12.

Key Laboratory of Molecular Target and Clinical Pharmacology of Guangdong Province, School of Pharmaceutical Sciences, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 511436, China,

Background: Sucrose allyl ether (SAE) containing hemostatic drugs and a photoinitiator was established to treat mild postpartum hemorrhage or long-term continuous abnormal uterine bleeding in minimally invasive surgery (MIS) using a photopolymerization method.

Methods And Results: Real-time infrared spectroscopy and rheological experiments showed that the SAE monomer with shear-thinning characteristics could polymerize rapidly into a transparent membrane. Cytotoxicity experiments in vitro showed that this system could elicit a long-term hemostatic effect. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/DDDT.S180842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420104PMC

Evaluation of Global Hemostatic Assays in Response to Factor VIII Inhibitors.

Clin Appl Thromb Hemost 2019 Jan-Dec;25:1076029619836171

1 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Global hemostatic assays including thromboelastography (TEG), Innovance ETP (endogenous thrombin potential), and Thrombinoscope could measure thrombin generation potential and be useful to guide management of patients with factor VIII (FVIII) inhibitors. However, the performance characteristics of these global assays in the presence of FVIII inhibitors are incompletely characterized. In this study, the normal range of thrombin generation potential was measured in 20 healthy individuals by all 3 assays. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1076029619836171DOI Listing

Thrombin generation test for evaluating hemostatic effects of Brazilian snake venoms.

Toxicon 2019 Mar 14. Epub 2019 Mar 14.

Clinical and Toxicological Department, Faculty of Pharmacy. Federal University of Minas Gerais, Brazil. Electronic address:

Snake venoms as well as their components have been tested worldwide to find new molecules for prophylaxis and treatment of several pathologies or even for diagnostic purposes. It is widely known that snake venoms contain enzymes and non-enzymatic proteins that interfere with hemostasis leading to hemorrhage or even thrombosis. The treatment of snake envenoming and the development of new drugs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxicon.2019.03.012DOI Listing

Wound healing potential of oil extracted from Parrotiopsis jacquemontiana (Decne) Rehder.

J Ethnopharmacol 2019 Mar 14;236:354-365. Epub 2019 Mar 14.

Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address:

Ethnopharmacological Relevance: Oil extracted from Parrotiopsis jacquemontiana stem traditionally used for wound healing, body aches and dermatitis. In this study we have evaluated oil for its phytoconstituents, antioxidant, antimicrobial and wound healing activities.

Methods: Phytochemical characterization of oil was determined by standard qualitative procedures, gas chromatography mass spectrometry technique (GC-MS) and Fourier transform infra-red spectroscopy (FT-IR). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.03.018DOI Listing

"Warning" to postoperative complications when using hemostatic agents!

Acta Neurochir (Wien) 2019 Mar 15. Epub 2019 Mar 15.

Department of Neurosurgery, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00701-019-03864-xDOI Listing
March 2019
1 Read

The Coagulopathy of Acute Type A Aortic Dissection: A Prospective, Observational Study.

J Cardiothorac Vasc Anesth 2019 Feb 11. Epub 2019 Feb 11.

Lund University, Skåne University Hospital, Department of Clinical Sciences, Lund, Department of Cardiothoracic Surgery, Lund, Sweden.

Objective: To evaluate the hemostatic system in patients undergoing surgery for acute type A aortic dissection (ATAAD) compared with those undergoing elective aortic procedures.

Design: This was a prospective, observational study.

Setting: The study was performed at a single university hospital. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10530770193014
Publisher Site
http://dx.doi.org/10.1053/j.jvca.2019.02.013DOI Listing
February 2019
2 Reads

Layperson Ability and Willingness to Use Hemostatic Dressings: A Randomized, Controlled Trial.

Prehosp Emerg Care 2019 Mar 15:1-11. Epub 2019 Mar 15.

c American Red Cross Scientific Advisory Council , Washington , United States.

Background: The Hartford Consensus and Stop the Bleed Campaign empower the public to stop bleeding. While evidence for civilian tourniquet use is mounting, there is limited evidence regarding the public's ability to use hemostatic dressings. This study seeks to determine if laypeople can apply hemostatic dressings, and which hemostatic dressing they can use most successfully. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10903127.2019.1593566DOI Listing

Hemostatic thrombin-gelatin matrix leading to intracranial cyst formation : case report.

World Neurosurg 2019 Mar 11. Epub 2019 Mar 11.

Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan, No.7, Zhongshan S. Rd., Zhongzheng Dist., Taipei City 10002, Taiwan.

Local hemostatic agents has been used in neurosurgical field for many years; it is safe and efficient with no fatal complication reported in the literature. We routinely used gelatin-thrombin hemostatic agent (Floseal Hemostatic Matrix (Baxter Healthcare Corp, Fremont, CA, USA)) for hemostasis in minimally invasive endoscopic-assisted surgery for more than 500 intracerebral hemorrhage patients. However, two cases with sterile cyst formation were encountered. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2019.03.030DOI Listing

Glial cells maintain synapses by inhibiting an activity-dependent retrograde protease signal.

PLoS Genet 2019 03 14;15(3):e1007948. Epub 2019 Mar 14.

Peptide Biology Laboratories, Salk Institute, La Jolla, CA, United States of America.

Glial cells regulate multiple aspects of synaptogenesis. In the absence of Schwann cells, a peripheral glial cell, motor neurons initially innervate muscle but then degenerate. Here, using a genetic approach, we show that neural activity-regulated negative factors produced by muscle drive neurodegeneration in Schwann cell-deficient mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1007948DOI Listing

Comparison of outcomes in totally tubeless percutaneous nephrolithotomy according to nephrostomy tract sealing with fibrin versus gelatin matrix: a propensity score matching study.

Urolithiasis 2019 Mar 14. Epub 2019 Mar 14.

Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.

To investigate and compare surgical outcomes in totally tubeless percutaneous nephrolithotomy (ttPCNL) patients according to the type of sealant during nephrostomy tract closure, the records of 158 patients who underwent ttPCNL were retrospectively reviewed. Fibrin sealant [Tisseel; n = 107, fibrin-only sealant (FS)] or gelatin matrix hemostatic sealant [FloSeal; n = 51, gelatin matrix sealant (GS)] was applied during tract closure according to surgeon's preference. On the first postoperative day, computed tomography (CT) was scanned for all patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00240-019-01126-0DOI Listing
March 2019
1 Read

The Inflammatory and Hemostatic Cardiovascular Risk Markers During Acute Hyperglycemic Crisis in Type 1 and Type 2 Diabetes.

J Med Biochem 2019 Apr 3;38(2):126-133. Epub 2019 Mar 3.

Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Background: We analyzed cardiovascular inflammatory (C-reactive protein (CRP), interleukin 6 (IL-6)), haemostatic (homocysteine) risk markers in lean and obese patients at admission and acute hyperglicemic crisis (AHC) resolving, involving diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS).

Methods: In that context, we included group A: N = 20 obese, B: N=20 lean patients with DKA; C: N = l0 obese, D: N=10 lean patients with HHS; E: N = 15 obese, F: N=15 lean controls. CRP IL-6, homocysteine were determined by ELISA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2478/jomb-2018-0024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410996PMC
April 2019
1 Read

Acquired von Willebrand Syndrome Associated with Cardiovascular Diseases.

J Atheroscler Thromb 2019 Mar 12. Epub 2019 Mar 12.

Department of Blood Transfusion Medicine, Nara Medical University.

The blood glycoprotein von Willebrand factor (VWF) plays an important role in hemostasis and thrombosis.VWF is produced and secreted as large multimers by endothelial cells and megakaryocytes. It is then cleaved in a sheer-stress dependent manner by a specific protease, ADAMTS13, into multimers consisting of 2-80 subunits. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5551/jat.RV17031DOI Listing
March 2019
1 Read

Application of a self-assembling peptide matrix prevents esophageal stricture after circumferential endoscopic submucosal dissection in a pig model.

PLoS One 2019 12;14(3):e0212362. Epub 2019 Mar 12.

Department of Gastroenterology, Cochin Hospital, APHP, Paris, France.

Introduction: Circumferential endoscopic submucosal dissection (ESD) allows to treat large esophageal superficial neoplasms, however with a high occurrence of severe esophageal strictures. In a previous work, we demonstrated that the application of a prototype of self-assembling peptide (SAP) matrix on esophageal wounds after a circumferential-ESD delayed the onset of esophageal stricture in a porcine model. The aim of this work was to consolidate these results using the commercialized version of this SAP matrix currently used as a hemostatic agent. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212362PLOS
March 2019
2 Reads

Impact of Marine Exposure on Hemostatic Gauzes Using Thromboelastography.

J Spec Oper Med 2019 ;19(1):89-94

Background: Military forces render emergency care in marine environments, where care for exsanguination is challenging. However, the effect of saltwater on the functionality of hemostatic agents is unknown. In this study, we used thromboelastography (TEG) to quantify the effect of saltwater on the efficacy of five gauze products. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/DOI Listing
January 2019
1 Read

Perioperative Desmopressin for Patients Undergoing Otolaryngologic Procedures: A Systematic Review.

Otolaryngol Head Neck Surg 2019 Mar 12:194599819831288. Epub 2019 Mar 12.

7 Department of Otolaryngology, University of Colorado School of Medicine, Aurora, Colorado, USA.

Objective: Desmopressin (DDAVP) is a hemostatic agent used to manage bleeding in patients with hemostatic disorders, and there is a lack of published data to guide its use during otolaryngology procedures. The objective of this study was to conduct an evidence-based systematic review of the reported uses, efficacy, and adverse effects of DDAVP in the otolaryngology surgical setting.

Data Sources: PubMed, MEDLINE, and EmBase were searched for articles on the use of DDAVP in otolaryngology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0194599819831288DOI Listing
March 2019
1 Read

[The condition of the hemostatic system in acute severe peritonitis during remaxol therapy].

Khirurgiia (Mosk) 2019 (2):65-71

National Research Mordovia State University, Saransk, Russia.

Aim: To evaluate the effectiveness of the Remaxol in the correction of hemostatic system in patients with severe acute peritonitis.

Material And Methods: 52 patients with acute peritonitis of different severity were examined, and divided into 4 groups: I - mild, II - moderate, III - severe. The patients of these groups had treated using standard therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17116/hirurgia201902165DOI Listing
January 2019

Pregnancy-Preserving Laparoscopic Treatment of Acute Hemoperitoneum Following Lutein Cyst Rupture in Early Gestation.

Authors:
Rafał Watrowski

Z Geburtshilfe Neonatol 2019 Mar 7. Epub 2019 Mar 7.

St. Josefskrankenhaus, Teaching Hospital of the University of Freiburg, Department of Gynecology and Obstetrics, Freiburg, Germany.

Acute hemoperitoneum (AHP) in early gestation is commonly treated via laparotomy. A ruptured corpus luteum (CL) cyst is a rare cause of AHP in pregnancy. This case report describes a 33-year-old, hemodynamically stable G2/P1 who presented at 5+5 gestational weeks with an acute abdomen due to ruptured CL cyst (7 cm). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0853-8131DOI Listing
March 2019
3 Reads

Plasma Levels of Vascular Endothelial Growth Factor and Selected Hemostatic Parameters in Association With Treatment Response in Multiple Myeloma.

Clin Appl Thromb Hemost 2019 Jan-Dec;25:1076029618823280

1 Department of Haematology and Transfusion Medicine, National Centre of Haemostasis and Thrombosis, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Kollarova, Martin, Slovakia.

Multiple myeloma (MM) is a neoplastic plasma cell disorder characterized by the clonal proliferation of plasma cells in the bone marrow and presence of monoclonal protein in the blood or urine. Diverse hemostatic abnormalities have been reported in patients with myeloma which predispose the patient to bleeding and also thrombosis. The aim of this study was to measure the concentrations of serum levels of vascular endothelial growth factor, D-dimer, and von Willebrand factor in patients with newly diagnosed or relapsed multiple myeloma before treatment, during therapy, and after successful therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1076029618823280DOI Listing
March 2019
2 Reads

Effects of Early Altitude Exposure on the Open Abdomen After Laparotomy in Trauma.

Mil Med 2019 Mar 6. Epub 2019 Mar 6.

Department of Surgery, College of Medicine, University of Cincinnati, Section of General Surgery, OH.

Introduction: While damage control surgery and resuscitation techniques have revolutionized the care of injured service members who sustain severe traumatic hemorrhage, the physiologic and inflammatory consequences of hemostatic resuscitation and staged abdominal surgery in the face of early aeromedical evacuation (AE) have not been investigated. We hypothesized that post-injury AE with an open abdomen would have significant physiologic and inflammatory consequences compared to AE with a closed abdomen.

Materials And Methods: Evaluation of resuscitation and staged abdominal closure was performed using a murine model of hemorrhagic shock with laparotomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/milmed/usz034DOI Listing
March 2019
4 Reads

Platelets compensate for poor thrombin generation in type 3 von Willebrand disease.

Platelets 2019 Mar 5:1-9. Epub 2019 Mar 5.

b Faculty of Medicine , University of Helsinki , Helsinki , Finland.

In type 3 von Willebrand disease (VWD3), the most severe form with absent von Willebrand factor (VWF), the bleeding phenotype is variable. Platelet contribution to the hemostatic defect in VWD3 calls upon further studies. We investigated the contribution of platelets to in vitro thrombin generation (TG) and platelet procoagulant activity in VWD3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09537104.2019.1581922DOI Listing
March 2019
2 Reads

Acute penetrating atherosclerotic ulcer of the ascending aorta.

J Card Surg 2019 Mar 5. Epub 2019 Mar 5.

Cardiac Surgery Department, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina.

A 67-year-old man presented with chest pain. Clinical examination revealed hypertension (160/90 mm Hg). Electrocardiogram indicated no acute coronary syndrome and cardiac enzymes were normal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocs.13999DOI Listing
March 2019
1 Read

Summary and Review of the Abstracts on Hemostasis/Thrombosis Presented at Haematocon 2018, Kochi.

Authors:
Prashant Sharma

Indian J Hematol Blood Transfus 2019 Jan 24;35(1):32-36. Epub 2019 Jan 24.

Department of Hematology, Postgraduate Institute of Medical Education and Research, Level 5, Research Block A, Sector 12, Chandigarh, 160012 India.

The hemostatic pathways involve a complex interplay of a vast array of inherited and acquired factors. Derangements of these pathways lead to several disorders that are complex and challenging not just for laboratory and clinical hematologists but also of concern to public health officials and policy makers. The past decade has seen an increased focus on research in this area with several recent meetings focusing on the diagnosis and management of persons afflicted with these disorders. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12288-019-01076-y
Publisher Site
http://dx.doi.org/10.1007/s12288-019-01076-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369065PMC
January 2019
5 Reads
0.234 Impact Factor

A Network Pharmacology Approach Used to Estimate the Active Ingredients of Moutan Cortex Charcoal and the Potential Targets in Hemorrhagic Diseases.

Biol Pharm Bull 2019 ;42(3):432-441

Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University.

Moutan Cortex charcoal has been used to ameliorate blood heat symptoms and treat pathologic hemorrhage down the ages. Although well known as an agent with the effect of astringency and hemostasis, its active ingredients and action mechanism remain unclear. In the present study, molecular docking technology was employed to screen the potential hemostatic compounds in Moutan Cortex charcoal and their target proteins. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1248/bpb.b18-00756DOI Listing
January 2019

Sickle cell disease: Hemostatic and inflammatory changes, and their interrelation.

Clin Chim Acta 2019 Feb 27;493:129-137. Epub 2019 Feb 27.

Federal University of São João del-Rei (UFSJ), Dona Lindu Center-West Campus, Sebastião Gonçalves Coelho Street, 400, Chanadour, 35501-296 Divinópolis, MG, Brazil. Electronic address:

Sickle cell disease, the most common genetic blood disorder in the world, has high clinical variability, negatively impacts quality of life and contributes to early mortality. Sickled erythrocytes cause blood flow obstruction, hemolysis, and several hemostatic changes that promote coagulation. These events, in turn, induce chronic inflammation, characterized by elevated plasma levels of pro-inflammatory markers, which aggravates the already unfavorable state of the circulatory system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cca.2019.02.026DOI Listing
February 2019
1 Read

"Warning" to postoperative complications when using hemostatic agents!

Acta Neurochir (Wien) 2019 Mar 1. Epub 2019 Mar 1.

Division of Breast Surgery, Department of Women's and Children's Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Largo A. Gemelli, 8, 00168, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00701-019-03863-yDOI Listing
March 2019
1 Read

Pediatric trauma-related coagulopathy: Balanced resuscitation, goal-directed therapy and viscoelastic assays.

Semin Pediatr Surg 2019 Feb 23;28(1):61-66. Epub 2019 Jan 23.

Department Surgery, Children's Hospital of Oakland, Oakland, CA, United States. Electronic address:

The improved understanding of trauma-induced coagulopathy in adults has led to an evolution in the strategies of damage-control resuscitation. While its impact on the care of pediatric trauma patients is of tremendous interest, the evidence is sparse, and a great deal of research is still needed in this domain. Areas of particular interest include age-related differences in hemostasis and balanced resuscitation, advances in functional coagulation assays and effective adjunctive medications, such as tranexamic acid, for hemorrhage control. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.sempedsurg.2019.01.011DOI Listing
February 2019

Treatment of gastrointestinal bleeding with hemostatic powder (TC-325): a multicenter study.

Surg Endosc 2019 Feb 28. Epub 2019 Feb 28.

Department of Gastrointestinal Endoscopy, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga #15. Col. Sección XVI. Del. Tlalpan., C.P. 14000, Mexico City, Mexico.

Introduction: Hemostatic powder (TC-325) is a new tool for treatment of gastrointestinal bleeding that allows the treatment of large surfaces with active bleeding. The aim was to describe the initial success of TC-325 for the control of GI bleeding.

Materials And Methods: We did a multicenter cohort study with patients admitted to the endoscopy service for GI bleeding. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00464-019-06719-9DOI Listing
February 2019

Endoscopic injection sclerotherapy for pediatric bleeding esophageal varices complicated by gastric vein, main portal vein, splenic mesenteric junction, and splenic vein occlusion: a case report.

BMC Gastroenterol 2019 Feb 28;19(1):37. Epub 2019 Feb 28.

Liver Transplant Program, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.

Background: Endoscopic injection sclerotherapy (EIS) is a life-saving procedure for pediatric patients with bleeding gastric varices (GV) associated with advanced liver cirrhosis and severe portal hypertension. Because of the lack of an endoscopic banding ligation device for pediatric patients, EIS is usually performed for bleeding esophageal varices (EV) in infants with congenital biliary atresia.

Case Presentation: We present a case of a 15-month-old female infant with type I biliary atresia with jaundice (total serum bilirubin, 22. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12876-019-0955-7DOI Listing
February 2019
1 Read

Paris polyphylla 26 triggers G2/M phase arrest and induces apoptosis in HepG2 cells via inhibition of the Akt signaling pathway.

J Int Med Res 2019 Feb 28:300060519826823. Epub 2019 Feb 28.

1 Department of General Surgery, The First Affiliated Hospital, Jinan University, Guangzhou, China.

Objectives: Paris polyphylla 26 (PP-26) is a monomer purified from Paris polyphylla, which has traditionally been used as an antimicrobial, hemostatic, and anticancer agent in China. The anti-proliferation effect and underlying molecular mechanism of PP-26 were investigated in vitro.

Methods: The effects of PP-26 on various tumor cells were detected by MTT assay. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0300060519826823DOI Listing
February 2019
1 Read

Efficacy of aminocaproic acid in the control of bleeding after total knee and hip arthroplasty: A systematic review and meta-analysis.

Medicine (Baltimore) 2019 Mar;98(9):e14764

Medical College of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu Province, China.

Background: To assess the effectiveness and safety of intravenous aminocaproic acid for blood management after total knee and hip arthroplasty.

Methods: Electronic databases: PubMed (1950.1-2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014764DOI Listing
March 2019
1 Read

In situ injectable hyaluronic acid/gelatin hydrogel for hemorrhage control.

Mater Sci Eng C Mater Biol Appl 2019 May 9;98:628-634. Epub 2019 Jan 9.

Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.. Electronic address:

Tissue sealants are used for hemorrhage control which is imperative in many surgical procedures. It is a highly challenging task to obtain the ideal tissue sealant. Only a few commercially tissue sealants are available to be used for internal tissue or organ hemorrhage control. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.msec.2019.01.034DOI Listing
May 2019
1 Read

Assessment of neonatal, cord, and adult platelet granule trafficking and secretion.

Platelets 2019 Feb 27:1-11. Epub 2019 Feb 27.

e The Hemophilia Center , Oregon Health & Science University , Portland , OR , USA.

Despite the transient hyporeactivity of neonatal platelets, full-term neonates do not display a bleeding tendency, suggesting potential compensatory mechanisms which allow for balanced and efficient neonatal hemostasis. This study aimed to utilize small-volume, whole blood platelet functional assays to assess the neonatal platelet response downstream of the hemostatic platelet agonists thrombin and adenosine diphosphate (ADP). Thrombin activates platelets via the protease-activated receptors (PARs) 1 and 4, whereas ADP signals via the receptors P2Y and P2Y as a positive feedback mediator of platelet activation. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/09537104.2019.1
Publisher Site
http://dx.doi.org/10.1080/09537104.2019.1573314DOI Listing
February 2019
4 Reads

Ontogeny of platelet function.

Blood Adv 2019 Feb;3(4):692-703

Walter Brendel Centre of Experimental Medicine, Biomedical Center and University Hospital of Ludwig-Maximilians University Munich, Martinsried, Germany.

Although the hemostatic potential of adult platelets has been investigated extensively, regulation of platelet function during fetal life is less clear. Recent studies have provided increasing evidence for a developmental control of platelet function during fetal ontogeny. Fetal platelets feature distinct differences in reactive properties compared with adults. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/bloodadvances.2018024372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391674PMC
February 2019
1 Read

Preparation and evaluation of Bletilla striata polysaccharide/graphene oxide composite hemostatic sponge.

Int J Biol Macromol 2019 Feb 23;130:827-835. Epub 2019 Feb 23.

College of Pharmacy, Southwest Minzu University, Chengdu 610041, China. Electronic address:

Uncontrolled bleeding is an important cause of military and civilian casualties. GO has received more attention in the field of hemostasis. However, pure GO has various limitation in application due to its potential thrombosis, hemolytic and cytotoxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2019.02.137DOI Listing
February 2019
2 Reads

Outcomes of operative vaginal delivery managed by residents under supervision and attending obstetricians: a prospective cross-sectional study.

Am J Obstet Gynecol 2019 Feb 23. Epub 2019 Feb 23.

Inserm CIC 1413, Nantes University Hospital, Nantes, France.

Background: To assess both severe maternal and neonatal mortality and morbidity after attempted operative vaginal deliveries by residents under supervision and by attending obstetricians.

Study Design: Secondary analysis of a five-year prospective study with cross-sectional analysis including 2192 women with live singleton term fetuses in vertex presentation who underwent an attempted operative vaginal delivery in a tertiary care university hospital. Obstetricians who attempted or performed an operative vaginal delivery were classified into two groups according to their level of experience: attending obstetricians (who had 5 years or more of experience) and obstetric residents (who had less than 5 years of experience) under the supervision of an attending obstetrician. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajog.2019.02.044DOI Listing
February 2019
1 Read

Educating Parents About Vitamin K in the Newborn Using Knowles' Theory of Adult Learning Principles as a Framework.

Crit Care Nurs Q 2019 Apr/Jun;42(2):205-207

Department of Nursing, University of North Carolina at Pembroke.

Parents must make an educated decision regarding vitamin K administration for their infant prior to birth. With an abundance of information available regarding this topic, the nurse needs to guide the parents through this process. Using Knowles' Theory of Adult Learning Principles as a framework can increase the parents' knowledge and assist the nurse in providing thorough information. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CNQ.0000000000000256DOI Listing
March 2019
1 Read

Hemorrhage Control: Lessons Learned From the Battlefield Use of Hemostatic Agents That Can Be Applied in a Hospital Setting.

Authors:
Herman A Allison

Crit Care Nurs Q 2019 Apr/Jun;42(2):165-172

SR-AHEC Family Practice Clinic, Fayetteville, North Carolina.

Uncontrolled blood loss is a major cause of preventable death worldwide. A severe injury can occur anywhere at any time. Controlling blood loss is an important issue for patient care in the hospital setting. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CNQ.0000000000000249DOI Listing
March 2019
1 Read

Device-Induced platelet dysfunction in mechanically assisted circulation increases the risks of thrombosis and bleeding.

Artif Organs 2019 Feb 25. Epub 2019 Feb 25.

Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.

Thrombotic and bleeding complications are the major obstacle for expanding mechanical circulatory support (MCS) beyond the current use. While providing the needed hemodynamic support, those devices can induce damage to blood, particularly, platelets. In this study, we investigated device-induced alteration of three major platelet surface receptors, von Willebrand factor (VWF) and associated hemostatic functions relevant to thrombosis and bleeding. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/aor.13445DOI Listing
February 2019
1 Read

Endothelial Microparticles and Blood Coagulation Activation in Head and Neck Cancer Patients Undergoing Radiotherapy or Radiochemotherapy.

In Vivo 2019 Mar-Apr;33(2):627-632

Department of Oncology, Medical University of Bialystok, Bialystok, Poland.

Background/aim: Endothelial microparticles (EMP) are small vesicles which are released from the endothelium and contribute to blood coagulation activation in various clinical settings. The aim of this study was to examine whether EMP influence blood coagulation activation in cancer patients during radiotherapy/radiochemotherapy (RT/RCT).

Materials And Methods: Sixteen head and neck cancer (HNC) patients undergoing RT/RCT and 10 controls were examined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/invivo.11520DOI Listing
January 2019

The Effect of Haemostatic Dressing Prototypes for the Emergency Services in the Porcine Haemostatic System.

In Vivo 2019 Mar-Apr;33(2):359-363

Department of Surgery and Radiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.

Background/aim: Coagulopathy can develop when hemostatic dressings are used to stop massive bleeding, even in patients without prior history of clotting disorders. The selection of procoagulants, which effectively control bleeding and prevent disseminated intravascular coagulation (DIC) and thrombosis, is a significant challenge. The aim of this study was to evaluate the effect of two prototypes of haemostatic dressing in the porcine haemostatic system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/invivo.11482DOI Listing
December 2018
1 Read

Lyophilizing thrombin powder-based treatment for hemostasis during coil embolization of ruptured cerebral aneurysm: Two case reports.

Interv Neuroradiol 2019 Feb 25:1591019918824866. Epub 2019 Feb 25.

2 Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: Rupture of cerebral aneurysm is an inevitable complication during embolization, followed by subsequent acute subarachnoid hemorrhage or intracranial hematoma, and results in the aggravation of a patient's condition. In particular, for patients who have had a ruptured aneurysm, urgent treatment strategies are required during operation. The most common hemostatic methods seen in clinical practices are as follows: after lowering the blood pressure, we continue to embolize the aneurysms with detachable coils as soon as possible or inject with Glubran/Onyx embolization liquids, as well as use a balloon catheter to temporarily block the blood supply. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1591019918824866DOI Listing
February 2019
1 Read
0.730 Impact Factor