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JAMA Ophthalmol 2021 May 6. Epub 2021 May 6.

Joslin Diabetes Center, Beetham Eye Institute, Harvard Department of Ophthalmology, Boston, Massachusetts.

Importance: Although there were no differences in mean visual acuity (VA) over 24 weeks after vitrectomy with panretinal photocoagulation (PRP) vs aflibercept in a randomized clinical trial among eyes with vitreous hemorrhage due to proliferative diabetic retinopathy (PDR), post hoc analyses may influence treatment choices.

Objective: To compare exploratory outcomes between treatment groups that may affect treatment choices for patients with vitreous hemorrhage due to PDR.

Design, Setting, And Participants: This post hoc analysis of a randomized clinical trial conducted at 39 DRCR Retina Network sites included adults with vision loss due to PDR-related vitreous hemorrhage for whom vitrectomy was considered. Read More

Turk J Ophthalmol 2021 04;51(2):102-106

İstanbul Retina Institute, İstanbul, Turkey

Objectives: To investigate visual and anatomical outcomes of vitreoretinal surgeries in patients with Eales' disease.

Materials And Methods: In this retrospective study, 22 eyes of 21 patients with vitreous hemorrhage (VH) or tractional retinal detachment (TRD) secondary to Eales' disease who underwent vitreoretinal surgery between January 1997 and December 2015 and had at least 1 year of follow-up were included.

Results: The mean best corrected visual acuity (BCVA) was significantly higher at final visit (0. Read More

Graefes Arch Clin Exp Ophthalmol 2021 Apr 29. Epub 2021 Apr 29.

Department of Ophthalmology, National Taiwan University Hospital, No 7, Chung-Shan S. Rd., Taipei, 100, Taiwan.

Purpose: To report the short-term outcomes of a modified small-incision technique for implantation of scleral-fixated intraocular lenses (IOLs) using Gore-Tex sutures.

Methods: A retrospective, interventional, consecutive case series was conducted. From June 2019 to February 2020, 10 patients underwent small-incision scleral-fixated IOL implantation using Gore-Tex sutures at a tertiary referral center. Read More

Am J Ophthalmol Case Rep 2021 Jun 8;22:101086. Epub 2021 Apr 8.

Erie Retinal Surgery, Erie, PA, 16507, USA.

Purpose: We present a patient with vaso-occlusive retinal vasculitis to summarize this uncommon entity and review the clinical features and management challenges applicable to patients with retinal vasculitis.

Observations: A 76-year-old male presented with sudden-onset severe central vision loss. On examination, vitreous hemorrhage, neovascularization of the optic nerve, peripheral segmental periphlebitis, vessel sclerosis, vascular sheathing, and retinal hemorrhages were observed, and a diagnosis of active vaso-occlusive retinal vasculitis was made. Read More

BMC Ophthalmol 2021 Apr 28;21(1):190. Epub 2021 Apr 28.

Sakura Medical Center, Toho University, 285-8741 Sakura-shi, Chiba, Japan.

Background: The purpose of this study is to evaluate the influence of anti-vascular endothelial growth factor (VEGF) in the appearance or progression of epiretinal membranes (ERMs) in age-related macular degeneration (ARMD) and investigate confounding factors causing ERMs.

Methods: Seventy-six eyes that were treated for more than 36 months from the first anti-VEGF injection were assessed. Binary logistic regression analysis was performed between smoking, lens status, subretinal hemorrhage, posterior vitreous detachment (PVD) status, peripheral retinal degeneration, type of AMD, conditions of contralateral eye, and the number of injections as independent variables and appearance or progression of ERMs during 36 months as dependent variables. Read More

Int J Retina Vitreous 2021 Apr 26;7(1):35. Epub 2021 Apr 26.

Department of Ophthalmology, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, 14048-900, Brazil.

Background: The main purpose of this study is to compare the vitreous hemorrhage (VH) score reduction and visual acuity outcomes in patients with VH secondary to proliferative diabetic retinopathy (PDR) treated with intravitreal injections of bevacizumab (IVB) versus IVB and pars plana vitrectomy (IVB and PPV).

Methods: Patients with VH secondary to PDR were randomized into 2 groups: in Group A, patients were treated with a total of 3 IVB (1.5 mg/0. Read More

J Glaucoma 2021 Apr 23. Epub 2021 Apr 23.

Bernard and Shirlee Brown Glaucoma Research Laboratory, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, NY.

Purpose: To report two unusual cases of optic disc hemorrhage occurring following pharmacologic mydriasis.

Observation: A 78-year old woman and 60-year old man with primary open angle glaucoma developed optic disc hemorrhages shortly after pupillary dilation.

Conclusion And Importance: Cycloplegia may cause subtle shifts in vitreous and lamina cribrosa position that may result in the formation of optic disc hemorrhages in susceptible glaucomatous eyes. Read More

Injury 2021 Apr 20. Epub 2021 Apr 20.

Ophthalmic research center, Shahid Beheshti university of medical sciences, Tehran, Iran. Electronic address:

Purpose: To evaluate and compare the accuracy of axial versus coronal computerized tomography (CT) scan in detection of open globe injury.

Method: In this retrospective study, records of 61 patients with open and 72 patients with closed globe injury were reviewed. One experienced ophthalmologist and one neuroradiologist read the orbital CT scans and accuracy of the axial and coronal planes in detecting open globe injuries were compared. Read More

Am J Ophthalmol 2021 Apr 22. Epub 2021 Apr 22.

Byers Eye Institute, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, United States; Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States. Electronic address:

Purpose: To examine associations between primary repair, patient characteristics, and rhegmatogenous retinal detachment (RRD) reoperation.

Design: Retrospective cohort study METHODS: We used administrative claims to identify enrollees with incident RRD treatment by laser barricade, pneumatic retinopexy (PR), pars plana vitrectomy (PPV), or scleral buckle (SB) between 2003 and 2016. Analysis excluded patients with less than three years of continuous enrollment, previous RRD diagnosis, or repair. Read More

Eur J Ophthalmol 2021 Apr 23:11206721211012200. Epub 2021 Apr 23.

Moorfields Eye Hospital NHS Foundation Trust, London, UK.

Purpose: To describe the application of a modified Ahmed glaucoma valve (AGV) surgical implantation technique in vitrectomized eyes, in order to minimize the risk of early postoperative hypotony, which leads to hemorrhagic complications.

Materials And Methods: Data of patients implanted with AGV using the surgical technique described were retrospectively reviewed. Inclusion criterion: glaucomatous eyes with previous history of pars plana vitrectomy. Read More

Eur J Ophthalmol 2021 Apr 16:11206721211009179. Epub 2021 Apr 16.

Department of ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Introduction: We report a novel phenotype of mandibular hypoplasia, deafness, and progeroid features with lipodystrophy (MDPL) syndrome with mutation in a Chinese girl.

Case Description: Diabetic retinopathy was detected as the primary manifestation in a Chinese girl with MDPL syndrome carrying a known mutation (c.1812_1814delCTC, p. Read More

PLoS One 2021 15;16(4):e0249898. Epub 2021 Apr 15.

Department of Ophthalmology and Visual Sciences, Yamagata University Faculty of Medicine, Yamagata, Japan.

This study aimed to evaluate the 3-year long-term outcomes of primary Baerveldt glaucoma implant (BGI) surgery for neovascular glaucoma (NVG). We retrospectively evaluated 27 consecutive patients with NVG between November 2013 and November 2017. All the patients were treated with panretinal photocoagulation and pars plana vitrectomy before BGI surgery without anti-vascular endothelial growth factor treatment. Read More

Int Med Case Rep J 2021 7;14:219-222. Epub 2021 Apr 7.

Department of Ophthalmology, Tabuk University, Tabuk, Saudi Arabia.

Purpose: To report the poor visual outcome of ruptured globe caused by camel bites.

Observations: A 48-year-old camel caregiver presented to the emergency department after being bitten by a camel in the left side of his face. Ophthalmic examination revealed a superior scleral wound from 9 to 2 o'clock, about 6 mm from the limbus extending to the equator with prolapse of uveal and vitreous tissues, an opaque cornea, total hyphema, diffuse subconjunctival hemorrhage, and a lower lid laceration involving the lid margin and the nasolacrimal duct. Read More

J Vitreoretin Dis 2021 Jan 30;5(1):68-71. Epub 2020 Sep 30.

Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, 900 NW 17th Avenue, Miami, FL, 33136, USA.

A 13-year old male presented with bilateral intraocular foreign bodies (IOFBs) after a bullet struck his iPhone. The right eye vision was 20/50 and examination disclosed a limbal entry wound at 6:00, dense traumatic cataract, and vitreous hemorrhage. The left eye was 20/40 and an entry wound located roughly 4mm posterior to the limbus was noted. Read More

J Fr Ophtalmol 2021 Apr 7. Epub 2021 Apr 7.

Department of Statistics, Bursa Uludag University, School of Medicine, Bursa, Turkey.

Purpose: To assess the effect of foreign body volume on visual and anatomic outcomes in patients with a posterior segment intraocular foreign body (IOFB).

Methods: Patients were divided into three groups according to the volume of the IOFB; group 1 (n=18 eyes) with IOFBs<2mm, group 2 (n=15 eyes) with 2mm≤IOFBs<6mm, group 3 (n=18 eyes) with IOFBs≥6mm. All eyes underwent pars plana vitrectomy (PPV) for removal of the IOFB. Read More

BMC Ophthalmol 2021 Apr 10;21(1):173. Epub 2021 Apr 10.

Department of Ophthalmology, Westmead Hospital, Corner of Hawkesbury and Darcy Roads, Westmead, Sydney, NSW, 2145, Australia.

Background: To identify prognostic factors determining final visual outcome following open globe injuries.

Methods: Retrospective case series of patients presenting to Westmead Hospital, Sydney, Australia with open globe injuries from 1st January 2005 to 31st December 2017. Data collected included demographic information, ocular injury details, management and initial and final visual acuities. Read More

Int Med Case Rep J 2021 31;14:205-210. Epub 2021 Mar 31.

Division of Plastic Reconstruction, Department of Ear, Nose and Throat, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Introduction: Ophthalmic trauma is defined as injuries affecting the ocular structures, including the globe, eyelid, lacrimal system, and surrounding orbital walls. Blunt trauma acts as the leading cause of injury and it may affect both the anterior and posterior parts of the globe. Prompt diagnosis, early management, and sustained follow-up are mandatory for an optimal outcome. Read More

Clin Transl Oncol 2021 Apr 7. Epub 2021 Apr 7.

Department of Neurosurgery, Desert Regional Medical Center, Palm Springs, CA, USA.

Background: Intra-arterial chemotherapy is a new retinoblastoma treatment associated with high rates of globe salvage that has been widely adopted for primary treatment of retinoblastoma but is less frequently used as secondary treatment for refractory retinoblastoma. This systematic review aims to summarize the reported outcomes of intra-arterial chemotherapy for refractory retinoblastoma.

Methods: We conducted a systematic review of studies published on PubMed, Medline, and Embase from 2011 to 2021 reporting globe salvage rates following intra-arterial chemotherapy for secondary treatment of refractory retinoblastoma. Read More

Eye (Lond) 2021 Apr 6. Epub 2021 Apr 6.

Shanghai Aier Eye Hospital, Shanghai, PR China.

Purpose: To evaluate the efficacy of intravitreal conbercept (IVC) in pars plana vitrectomy (PPV) for patients with proliferative diabetic retinopathy (PDR).

Methods: A meta-analysis of randomized control trials (RCTs) using online databases was performed. The intraoperative outcome measures were the incidence of intraoperative bleeding and endodiathermy application, and the mean surgical time. Read More

Rom J Ophthalmol 2021 Jan-Mar;65(1):76-79

Retina and Vitreous Department, Grupo Oftalmológico Abdala-Figuerola AF, Barranquilla, Colombia.

A 16-year-old male patient presented with a 12-days sudden painless loss of vision in his left eye after diving in a lake. Best corrected visual acuity (BCVA) in the left eye was counting fingers. Anterior segment was unremarkable. Read More

Middle East Afr J Ophthalmol 2020 Oct-Dec;27(4):228-230. Epub 2021 Jan 19.

Department of Ophthalmology, College of Medicine, King Saud University, Jeddah, Saudi Arabia.

Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS), also known as familial retinal arterial macroaneurysm syndrome, is an autosomal recessive disorder associated with many life-threatening complications. The disease is characterized by progressive multiple retinal arterial macroaneurysms, retinal arterial beading, and recurrent vitreous hemorrhage. Here, we describe the first case of RAMSVPS associated with peripheral ischemia evident on ultra-widefield fluorescein angiography. Read More

Am J Ophthalmol Case Rep 2021 Jun 5;22:101053. Epub 2021 Mar 5.

Department of Ophthalmology, Hirosaki University Graduate School of Medicine, 5 Zaifu, Hirosaki, Aomori, Japan.

Purpose: To describe a rare case of racemose hemangioma which developed spontaneous macular macroaneurysm (MA) rupture and vitreaous hemorrhage.

Observations: A 29-year-old healthy asian female visited our hospital and a racemose hemangioma was found in the left eye. At presentation, the best corrected visual acuity (BCVA) was 30/20 in her left eye. Read More

BMC Ophthalmol 2021 Mar 9;21(1):129. Epub 2021 Mar 9.

Ophthalmology Department, Third Medical Center of PLA General Hospital, No. 69, Yongding Road, Haidian District, Beijing, China.

Background: To evaluate the efficacy and outcomes of one-way surgical technique for the treatment of vitreous hemorrhage post vitrectomy on proliferative diabetic retinopathy (PDR) patients.

Methods: This retrospective case series include 47 PDR patients who had vitrectomy with balanced saline solution tamponade and have developed vitreous hemorrhage without significant absorption. The one-way air-fluid exchange procedure which involves the application of a 0. Read More

World J Clin Cases 2021 Mar;9(8):2001-2007

Department of Ophthalmology, The Fourth Affiliated Hospital of Nantong University/The First People's Hospital of Yancheng, Yancheng 224000, Jiangsu Province, China.

Background: To report the possible reasons for needle perforation and complications related to perforation, as well as the clinical management of subretinal hemorrhage (SRH) during retrobulbar injection.

Case Summary: A 65-year-old female was scheduled to undergo pars plana vitrectomy (PPV) in her left eye for rhegmatogenous retinal detachment (RRD). During retrobulbar anesthesia, needle perforation of the globe occurred. Read More

Evid Based Complement Alternat Med 2021 5;2021:6642600. Epub 2021 Mar 5.

Department of Ophthalmology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510020, China.

Background: Compound Xueshuantong capsule (CXC) and Hexuemingmu tablet (HXMMT) are two important Chinese patent medicines (CPMs) frequently used to treat proliferative diabetic retinopathy (PDR), especially when complicated with vitreous hemorrhage (VH). However, a network pharmacology approach to understand the therapeutic mechanisms of these two CPMs in PDR has not been applied.

Objective: To identify differences in the active ingredients between CXC and HXMMT and to comparatively predict and further analyze the molecular targets shared by these CPMs and PDR. Read More

Ophthalmology 2021 Apr;128(4):616

Associated Retinal Consultants PC, Royal Oak, Michigan.

Am J Ophthalmol Case Rep 2021 Jun 2;22:101041. Epub 2021 Mar 2.

Retina Institute of The Carolina and Macular Degeneration Center, Charlotte, NC, USA.

Purpose: To present a case of a patient with human immunodeficiency virus (HIV) disease and Kikuchi-Fujimoto disease (KFD) who presented with a unique pattern of retinopathy.

Observations: A 7-year-old Taiwanese girl with HIV disease who was recently diagnosed with KFD had a sudden onset of blurry vision in both eyes one month after her KFD systemic symptoms had relatively resolved. Ophthalmic examination showed decreased visual acuity in both eyes (OU). Read More

Int J Retina Vitreous 2021 Mar 16;7(1):21. Epub 2021 Mar 16.

Department of Ophthalmology, Faculdade de Medicina Do ABC, Avenida Principe de Gales, 821, Santo André, SP, 0906065, Brazil.

Background: To report four cases with interesting anatomical presentations of multilayer macular hemorrhages with preretinal hemorrhage possibly preventing subretinal involvement of the macular area.

Cases Presentation: Observational study of four patients presenting with macular hemorrhages.

Results: Four patients with multilayer macular hemorrhage due to different causes, presented with a halo-shaped submacular hemorrhage coincident with the preretinal hemorrhage borders. Read More

Int Med Case Rep J 2021 3;14:139-144. Epub 2021 Mar 3.

Ophthalmology Unit, Department of Surgery, Abia State University Teaching Hospital, Aba, Abia State, Nigeria.

Introduction: Chronic renal failure (CRF) is a multi-systemic disease affecting different organ systems of the body. Ocular manifestations of chronic renal disease include squint, subconjunctival hemorrhage, vitreous hemorrhage, neovascular glaucoma, cataracts and retinal detachment. These result in visual impairment or blindness. Read More

Eur J Ophthalmol 2021 Mar 11:11206721211000648. Epub 2021 Mar 11.

Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun, Jilin, China.

Purpose: To describe surgical management and establish visual outcomes of open globe injury (OGI) in pediatric patients requiring vitrectomy.

Methods: Forty-eight eyes of 48 pediatric patients underwent vitrectomy for OGI with secondary vitreoretinal complications in the eye center of Jilin University were included. Characteristics of patients, details of ocular examination and operation, presenting and final visual acuity were recorded. Read More