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J Ophthalmol 2019 17;2019:9481902. Epub 2019 Mar 17.

Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Thailand.

Purpose: To report characteristics and visual results in patients with PDR-associated complications following pars plana vitrectomy (PPV) in a tertiary center over an eight-year period.

Methods: Medical records of diabetic retinopathy patients receiving PPV between January 2007 and December 2014 for PDR-related complications were reviewed.

Results: A total of 890 consecutive PDR patients were included in the study. Read More

J Ophthalmol 2019 17;2019:7918237. Epub 2019 Mar 17.

Cukurova University, School of Medicine, Department of Ophthalmology, Adana, Turkey.

Background: With the advances in surgical tools, simultaneous removal of cataract associated with vitreoretinal disorders is gaining popularity. This combined surgery offers several advantages besides limitations. The aim of this study is to assess the outcome and complications of phacoemulsification combined with pars plana vitrectomy (PPV). Read More

J Emerg Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Background: Ocular point-of-care ultrasound (POCUS) is a fast and safe non-invasive procedure used to evaluate the structural integrity and pathology of the eye. Ocular POCUS can be used for evaluation of posterior chamber and orbital pathology, including retinal detachment, vitreous detachment or hemorrhage, foreign body, lens dislocation, and increased intracranial pressure.

Discussion: The purpose of this brief communication is to describe a technique for conducting an ocular POCUS that may in some cases be easier and more comfortable by adjusting the position of the sonographer relative to the patient. Read More

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):e125-e127

A 67-year-old female presented with vitreous hemorrhage and sub-internal limited membrane (ILM) hemorrhage in her right eye associated with ruptured retinal arterial macroaneurysm. During pars plana vitrectomy, intraoperative optical coherence tomography aided in the diagnosis of a small macular hole previously obscured by the sub-ILM hemorrhage. Nonexpansile gas was placed followed by postoperative prone positioning, and the hole closed successfully. Read More

Ophthalmologe 2019 Apr 17. Epub 2019 Apr 17.

Klinik für Augenheilkunde, Universitätsmedizin Göttingen, Göttingen, Deutschland.

Background: Sutured scleral fixation of an artificial posterior chamber lens is a frequently used method for the treatment of eyes with poor or absent capsular support; however, the complication profile is often considered unfavorable.

Objective: To analyze the postoperative complication profile.

Methods: In this monocentric and retrospective analysis of a consecutive case series of patients with standardized sutured scleral fixation of a posterior chamber lens between 2007 and 2017, the documented complications were categorized as a permanent threat to visual acuity, such as endophthalmitis, choroidal hemorrhage, retinal detachment and clinically relevant but without a permanent threat to visual acuity, such as hemorrhage and hypotension. Read More

Ocul Surf 2019 Apr 12. Epub 2019 Apr 12.

Centro de Oftalmología Barraquer, Barcelona, Spain; Institut Universitari Barraquer, Universitat Autònoma de Barcelona, Barcelona, Spain; Universitat Internacional de Catalunya, Barcelona, Spain.

Purpose: To compare anatomical and functional results between three types of keratoprosthesis (KPro) in chemical injury and autoimmune disease.

Methods: 70 clinically comparable cases were included as follows: Boston KPro Type 1 25 eyes, osteo-odonto-keratoprosthesis (OOKP) 23 eyes, Tibial bone KPro 22 eyes. Survival times for anatomical and functional success were evaluated with Kaplan-Meier estimations and Log-rank tests. Read More

Zhonghua Yan Ke Za Zhi 2019 Apr;55(4):294-301

Beijing Key Laboratory of Vision Loss and Restoration, Ministry of Education, Department of Ophthalmology, People's Hospital, Peking University, Beijing 100044, China.

To investigate the treatment of retinopathy of incontinentia pigmenti by anti-vascular endothelial growth factor. Retrospective study of 5 patients(8 eyes) diagnosed retinopathy of incontinentia pigmenti from 2005 to 2017, including 0 males and 5 females (8 eyes involved) with an average age of 2.4 months(range, 1-5 months). Read More

Zhonghua Yan Ke Za Zhi 2019 Apr;55(4):267-272

Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

To investigate the ocular manifestations of human immunodeficiency virus (HIV) and syphilis coinfection. A retrospective analysis of the ocular manifestations was carried out in 27 patients (54 eyes) diagnosed as syphilis and HIV coinfection by the Department of Infectious Medicine in Peking Union Medical College Hospital during the years of 2006-2017. The research included 26 males and 1 female, aging from 24 to 76 years old, with a mean age of 40. Read More

JAMA Netw Open 2019 Apr 5;2(4):e192162. Epub 2019 Apr 5.

Department of Emergency Medicine, University of California, Irvine.

Importance: Ocular symptoms represent approximately 2% to 3% of all emergency department (ED) visits. These disease processes may progress to permanent vision loss if not diagnosed and treated quickly. Use of ocular point-of-care ultrasonography (POCUS) may be effective for early and accurate detection of ocular disease. Read More

Curr Ophthalmol Rep 2019 Mar 2;7(1):66-72. Epub 2019 Feb 2.

Marina del Rey, CA.

Purpose Of Review: The aim of this review is to summarize developments in the treatment of active polypoidal choroidal vasculopathy (PCV). PCV is associated with a poor visual prognosis as a consequence the condition's hallmark polypoidal dilatation and a branching network resulting in recurrent hemorrhages and serous leakage.

Recent Findings: Recent research has provided new insights into the pathogenesis of PCV. Read More

JAMA Ophthalmol 2019 Apr 11;137(4):e190247. Epub 2019 Apr 11.

Vitreous Retina Macula Consultants of New York, New York.

Arq Bras Oftalmol 2019 Apr 8. Epub 2019 Apr 8.

Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Purpose: To compare the intravitreal concentrations of cellular mediators involved in neurodegeneration, inflammation, and angiogenesis in patients with proliferative diabetic retinopathy and other vitreoretinal diseases.

Methods: A multiplex bead immunoassay was used to measure vitreous levels of pigment epithelium-derived factor, serum amyloid P, C-reactive protein, complement C4, alpha-1 antitrypsin, vascular endothelial growth factor, platelet-derived growth factor-AA, platelet-derived growth factor-BB, interleukin-6, interleukin-8, interleukin-10, tumor necrosis factor alpha and beta in patients undergoing 23-gauge vitrectomy for proliferative diabetic retinopathy and other diagnoses (control group).

Results: We evaluated 55 patients, of whom 24 had proliferative diabetic retinopathy and 31 had other diagnoses including vitreous hemorrhage, retinal detachment, macular hole, and epiretinal membrane. Read More

Ophthalmology 2019 Apr 1. Epub 2019 Apr 1.

Genentech, Inc., South San Francisco, California.

Purpose: To evaluate the safety and efficacy of the Port Delivery System with ranibizumab (PDS) for neovascular age-related macular degeneration (nAMD) treatment.

Design: Phase 2, multicenter, randomized, active treatment-controlled clinical trial.

Participants: Patients diagnosed with nAMD within 9 months who had received ≥ 2 prior anti-vascular endothelial growth factor intravitreal injections and were responsive to treatment. Read More

Ophthalmol Retina 2019 Jan 25;3(1):53-60. Epub 2018 Aug 25.

Department of Ophthalmology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan.

Purpose: To investigate the visual outcomes of patients with traumatic maculopathy and massive subretinal hemorrhage (SRH) after closed-globe injury.

Design: Retrospective, noncomparative, and interventional case series.

Participants: Twenty-four patients with traumatic maculopathy and massive SRH after closed-globe injury. Read More

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1298-1308

Laboratory for Retinal Regeneration, Center for Biosystems Dynamics Research, RIKEN, Kobe, Japan.

Purpose: To report occurrence of acute severe inflammation after surgical implantation of mycoplasma-infected induced pluripotent stem cell-derived RPE (iPS-RPE) cells into the eyes of healthy primates, and determine the immunopathological mechanisms of the inflammation.

Methods: Ophthalmic allogeneic transplantation of iPS-RPE cells was performed in the subretina of major histocompatibility complex (MHC)-matched (two eyes) and MHC-mismatched (one eye) healthy cynomolgus monkeys. The clinical course after transplantation was observed using color fundus photography, fluorescence angiography, and optical coherence tomography. Read More

Retin Cases Brief Rep 2019 Mar 28. Epub 2019 Mar 28.

Retina Service, New England Eye Center, Tufts Medical Center, Boston, Massachusetts.

Purpose: To describe 2 cases of multilevel optic disk hemorrhages in adults without a posterior vitreous detachment.

Methods: The findings on clinical examination, color fundus photography, fluorescein angiography, spectral domain optical coherence tomography at presentation and follow-up are presented.

Results: Two patients ages 61 and 49 years presented with unilateral floaters secondary to microscopic vitreous hemorrhage. Read More

Ophthalmol Retina 2019 Feb 20;3(2):140-145. Epub 2018 Sep 20.

Department of Ophthalmology & Vision Science, University of California, Davis, Sacramento, CA.

Objective: To evaluate the outcomes of patients undergoing pneumatic retinopexy (PR) performed by vitreoretinal fellows at 6 academic centers in the United States.

Design: Retrospective, multicenter, consecutive case series.

Participants: 483 patients with primary retinal detachments who underwent PR by 49 vitreoretinal fellows from 6 U. Read More

Acta Diabetol 2019 Mar 25. Epub 2019 Mar 25.

Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan Er Road, Yuexiu District, Guangzhou, Guangdong, China.

Aims: To compare the vitreous levels of chemokines in diabetic patients with and without retinopathy. To find the relationship between stages of diabetic retinopathy (DR) and levels of vitreous chemokines.

Methods: The study involved 20 non-diabetic and 20 diabetic patients without clinical signs of DR (NDR) and 40 diabetic patients with proliferative diabetic retinopathy (PDR). Read More

Ann Emerg Med 2019 Mar 21. Epub 2019 Mar 21.

Department of Emergency Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC. Electronic address:

Study Objective: Traumatic eye injuries are common emergency department presentations worldwide, and diagnosis may be delayed because of concurrent injuries and lack of guidelines in regard to the utility of clinical examination, computed tomography (CT), and point-of-care ultrasonography. In this study, we compare point-of-care ultrasonography with ophthalmologist clinical examination and CT for 6 types of traumatic eye injury.

Methods: We conducted a prospective cohort study evaluating patients with suspected traumatic eye injury who were recruited at an academic medical center in Tabriz, Iran. Read More

Indian J Ophthalmol 2019 Apr;67(4):561-563

Vitreo-Retina and Uvea Services, Sadguru Netra Chikitsalaya, Chitrakoot, Madhya Pradesh, India.

Retinal cavernous hemangiomas is a rare vascular tumor, isolated and non-progressive. This tumor is incidentally diagnosed on fundus examination and visual impairment can be rare presentation from vitreous hemorrhage, pre-retinal traction, hyphema, or macular scarring. The tumor has typical appearance of grape-like clusters of dilated vascular sacs with variable surface gliosis. Read More

Arch Med Sci 2019 Mar 2;15(2):449-456. Epub 2018 Feb 2.

School of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

Introduction: The aim of the study was to investigate the effects of vascular endothelial growth factor (VEGF) concentration in vitreous on postoperative complications after pars plana vitrectomy (PPV).

Material And Methods: Ninety subjects were surgically treated with PPV and followed up for 12 months at the Clinical Centre University Sarajevo, Clinic for Eye Disease. Exclusion criteria were presence of other eye diseases, systemic acute/chronic inflammatory conditions, or malignant neoplasms; previously performed PPV surgery; previously received intravitreal or systemic anti-VEGF therapy. Read More

Graefes Arch Clin Exp Ophthalmol 2019 Mar 20. Epub 2019 Mar 20.

Vitreoretinal Division, King Khaled Eye Specialist Hospital, Al-Oruba Street, 7191, Riyadh, 11462, Kingdom of Saudi Arabia.

Purpose: To provide a focused review of sickle cell retinopathy in the light of recent advances in the pathogenesis, multimodal retinal imaging, management of the condition, and migration trends, which may lead to increased prevalence of the condition in the Western world.

Methods: Non-systematic focused literature review.

Results: Sickle retinopathy results from aggregation of abnormal hemoglobin in the red blood cells in the retinal microcirculation, leading to reduced deformability of the red blood cells, stagnant blood flow in the retinal precapillary arterioles, thrombosis, and ischemia. Read More

J Ophthalmol 2019 13;2019:5208092. Epub 2019 Feb 13.

Eye Center, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, Jilin 130021, China.

Aim: To describe epidemiologic and clinical characteristics and prognostic factors influencing visual outcome after intraocular foreign bodies (IOFBs) injury.

Methods: Medical records of 370 patients (373 eyes) with IOFBs were reviewed to identify the factors influencing visual acuity by univariate and multivariate analyses.

Results: The majority of patients (97. Read More

Ophthalmic Surg Lasers Imaging Retina 2019 Mar;50(3):e77-e80

Intraocular corticosteroids are used in ophthalmologic conditions such as macular edema secondary to vascular occlusions, diabetes, and uveitis. Infectious ocular diseases must be ruled out before intravitreal corticosteroid implantation. Here, the authors report a case that has been referred to their clinic for surgical treatment due to dense vitreous hemorrhage in the right eye after bilateral intravitreal dexamethasone implantation. Read More

Retina 2019 Feb 15. Epub 2019 Feb 15.

Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts.

Purpose: To determine the preoperative characteristics, intraoperative and postoperative complications, and outcomes of eyes with posteriorly inserted vitreous base.

Methods: In this retrospective, observational, consecutive case series at 2 academic centers, 37 patients were studied who had posteriorly inserted vitreous base noted during vitrectomy. Posteriorly inserted vitreous base was defined as the insertion of the posterior hyaloid membrane being located posterior to the vortex veins. Read More

Am J Ophthalmol 2019 Mar 13. Epub 2019 Mar 13.

University of Michigan, Kellogg Eye Center, Department of Ophthalmology and Visual Sciences.

Purpose: To illustrate that patients with diabetic retinopathy who are treated exclusively with anti-VEGF therapy and have an interruption in treatment may experience marked progression of disease with potentially devastating visual consequences.

Design: Retrospective, multicenter, case series METHODS: Retrospective review of patients treated exclusively with anti-VEGF therapy for proliferative (PDR) or non-proliferative diabetic retinopathy (NPDR), with or without diabetic macular edema (DME), and temporarily lost to follow-up. Baseline disease characteristics, cause and duration of the treatment interruption, and resulting disease progression, complications, and outcomes were assessed. Read More

Diabetes Metab J 2019 Feb 20. Epub 2019 Feb 20.

Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Korea.

Background: To investigate the effects of dipeptidyl peptidase-4 inhibitor (DPP4i) as add-on medications to metformin on progression of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus, compared with sulfonylurea (SU) or thiazolidinedione (TZD).

Methods: We identified 4,447 patients with DPP4i, 6,136 with SU, and 617 with TZD in addition to metformin therapy from the database of Korean National Health Insurance Service between January 2013 and December 2015. Cox proportional hazards regression models were used to calculate hazard ratios (HRs) for DR progression. Read More

Am J Ophthalmol Case Rep 2019 Jun 16;14:39-46. Epub 2019 Feb 16.

Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.

Purpose: To describe new cases of sclopetaria and evaluate the risk factors, management, and visual prognosis of all reported cases in the literature.

Observations: We performed a retrospective, observational case series. This study included six cases (median age 23, interquartile range 33) of sclopetaria. Read More

Medwave 2019 Jan 25;19(1):e7512. Epub 2019 Jan 25.

Proyecto Epistemonikos, Santiago, Chile; Departamento de Oftalmología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Email: Address: Centro Evidencia UC, Pontificia Universidad Católica de Chile, Diagonal Paraguay 476, Santiago, Chile.

Update: This Living FRISBEE (Living FRIendly Summary of the Body of Evidence using Epistemonikos) is an update of the summary published in December 2014.

Introduction: Proliferative diabetic retinopathy can cause severe vision loss and even blindness if left untreated. Vitrectomy is often required in the treatment of more severe cases. Read More

Ophthalmologe 2019 Feb 27. Epub 2019 Feb 27.

Universitätsklinik und Poliklinik für Augenheilkunde, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Str. 40, 06120, Halle (Saale), Deutschland.

Introduction: Subhyaloidal premacular hemorrhage (SPH) causes a painless acute loss of vision with central scotoma. Typically, it can be caused by vascular retinal diseases or in the context of a Valsalva retinopathy. Ocular trauma is a less common cause of SPH. Read More

BMC Ophthalmol 2019 Feb 26;19(1):61. Epub 2019 Feb 26.

Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai Key Laboratory of Visual Impairmentand Restoration of Fudan University, Shanghai, 200031, China.

Background: To evaluate the efficacy, complications, and clinical characteristics, including the ocular toxicity, of intravitreal melphalan(IVM) treatment for vitreous seeding in Chinese retinoblastoma patients.

Methods: This was a retrospective, non-comparative analysis including 30 consecutive eyes of 23 patients with viable persistent or recurrent vitreous seeding following retinoblastoma treatment. All of the eyes received IVM injections (20-33 μg). Read More

Ocul Immunol Inflamm 2019 Feb 26:1-3. Epub 2019 Feb 26.

a Advanced Eye Centre , Post Graduate Institute of Medical Education and Research , Chandigarh , India.

Background: Klebsiella endogenous endophthalmitis (EE) is commonly seen in patients with hepato-biliary disease and urinary tract infections. Subretinal abscess with vitreous cells is the usual presentation and requires intensive treatment with systemic and intravitreal antibiotics along with prompt vitrectomy. Subretinal hemorrhage surrounding a choroidal mass has not been reported as the presenting feature of endogenous bacterial endophthalmitis. Read More

Indian J Ophthalmol 2019 Mar;67(3):419-423

Department of Vitreoretina, ICARE Eye Hospital and Postgraduate Institute, Noida, U.P, India.

Five Indian patients presenting with unilateral vitreous hemorrhage (VH) underwent pars plana vitrectomy (PPV) and were found to have lesions suggestive of peripheral exudative hemorrhagic chorioretinopathy (PEHCR). All eyes had extensive sub-retinal hemorrhage; three also showed an elevated mass lesion. The temporal retina anterior to the equator was the most commonly affected site. Read More

Ophthalmic Surg Lasers Imaging Retina 2019 02;50(2):e23-e25

Background And Objectives: Ozurdex intravitreal injection is performed via a patented injection device. However, there is a common misconception among ophthalmologists regarding the relation between the speed of applicator button depression and the speed of pellet injection.

Patients And Methods: Six dexamethasone intravitreal implants were injected into a calibrated ex vivo water bath. Read More

Fed Pract 2018 Jun;35(6):38-39

is a Staff Optometrist at the Manchester VA Medical Center in New Hampshire. is Chief of Optometry, and is Chief of Ophthalmology, both at the Providence VA Medical Center in Rhode Island. Dr. Huang and Dr. Mega are adjunct faculty at New England College of Optometry in Boston, Massachusetts. Dr. Greenberg is Professor of Surgery (Ophthalmology) at Warren Alpert Medical School of Brown University in Providence.

Although uncommon, vascular loops should be kept in the differential diagnosis of vitreous hemorrhage, and patients should seek care if experiencing new floaters or visual loss. Read More

Ophthalmologica 2019 Feb 14:1-7. Epub 2019 Feb 14.

Department of Ophthalmology, College of Medicine, Hallym University, Hwaseong, Republic of Korea,

Purpose: To assess treatment efficacy of scleral buckling surgery with wide-field surgical microscope and 27-gauge (G) chandelier illumination for rhegmatogenous retinal detachment (RRD).

Methods: This study is a retrospective chart review of 29 eyes in 29 patients with RRD who underwent scleral buckling surgery with a wide-field surgical microscope and 27-G chandelier illumination fiber inserted into the sclera at the pars plana. Results are expressed as mean ± standard deviation. Read More

Korean J Ophthalmol 2019 Feb;33(1):46-53

Department of Ophthalmology and Visual Science, The Catholic University of Korea College of Medicine, Seoul, Korea.

Purpose: To investigate the risk factors of diabetic nephropathy in patients with diabetic retinopathy requiring panretinal photocoagulation (PRP) and the visual prognosis.

Methods: A retrospective review of electronic medical records was conducted at Seoul St. Mary's Hospital, comprising 103 patients with type 2 diabetes mellitus and diabetic retinopathy who underwent PRP from 1996 to 2005. Read More

Medicine (Baltimore) 2019 Feb;98(6):e14354

Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Rationale: Increases in cosmetic laser use have led to recent reports of accidental retinal injuries, most of which are limited to the posterior pole. We report a case of peripheral retinal injury caused by a 1064-nm Nd:YAG: neodymium-doped yttrium aluminum garnet.

Patient Concerns: A 27-year-old Asian woman was admitted with scotoma symptoms in her right eye. Read More

J Ophthalmol 2019 2;2019:7464123. Epub 2019 Jan 2.

The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.

Purpose: To investigate the efficacy and safety of combined vitrectomy with tumor resection in the treatment of retinal vasoproliferative tumors (RVPT).

Methods: Retrospective study. RVPT patients who underwent vitreous surgery at the Eye Hospital of Wenzhou Medical University from January 2011 to July 2017 were included. Read More

Asia Pac J Ophthalmol (Phila) 2019 Feb 4. Epub 2019 Feb 4.

Department of Radiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Purpose: To study the safety and efficacy of intra-arterial chemotherapy (IAC) as a treatment for intraocular retinoblastoma in Thailand.

Design: Retrospective, interventional case series.

Methods: In this study, IAC was performed as primary or secondary treatment for patients with intraocular retinoblastoma using melphalan with or without additional topotecan or carboplatin. Read More

Ophthalmology 2019 Jan 31. Epub 2019 Jan 31.

Department of Ophthalmology, Oakland University William Beaumont School of Medicine, Associated Retinal Consultants, Royal Oak, Michigan. Electronic address:

Purpose: To report the structural and functional outcomes of autologous neurosensory retinal transplant for closure of refractory large macular holes (MHs).

Design: Multicenter, retrospective, consecutive case series.

Participants: A total of 41 eyes of 41 patients with a full-thickness MH refractory to prior vitrectomy with internal limiting membrane (ILM) peel and tamponade. Read More

Pediatr Emerg Care 2019 Jan 29. Epub 2019 Jan 29.

From the Departments of Ophthalmology, and.

Objectives: The aim of this study was to compare the role of computed tomography (CT) in the diagnosis of open-globe trauma and intraocular foreign body (IOFB) in pediatric and adult age groups.

Methods: Medical records of cases with open-globe trauma at Inonu University Hospital's Ophthalmology Emergency Service were retrospectively evaluated. Preoperative orbital CT images of the cases obtained at emergency services and their clinical and/or surgical findings were compared in pediatric and adult groups. Read More

J Ophthalmol 2018 27;2018:9250425. Epub 2018 Dec 27.

Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, 270 Xueyuan Road, Wenzhou, Zhejiang Province 325027, China.

Purpose: To report a new technique for sutureless intrascleral fixation of three-piece foldable intraocular lenses (IOLs) using 25-gauge trocars.

Methods: We performed this technique on patients with insufficient posterior capsule support. Seventeen eyes from 15 patients with aphakia, dislocated IOL, or subluxated crystalline lens undergoing posterior chamber sutureless implantation of an IOL were studied. Read More

Medicine (Baltimore) 2019 Jan;98(4):e14271

Department of Ophthalmology, Osaka Medical College, Takatsuki-City, Osaka, Japan.

Rationale: We experienced 2 cases of retinal detachment (RD) with giant tears located in the intermediate periphery of the fundus. In this case report, we investigated the clinical characteristics in these 2 cases.

Patient Concerns And Diagnoses: Case 1 involved a 63-year-old male, who became aware of metamorphopsia and decreased visual acuity (VA) in his left eye. Read More

Int J Retina Vitreous 2019 15;5. Epub 2019 Jan 15.

1Department of Ophthalmology, Ribeirão Preto School of Medicine, University of São Paulo, 3900, Bandeirantes Avenue, Ribeirão Prêto, SP 14049-900 Brazil.

Background: The congenital simple hamartoma of the retinal pigment epithelium is a benign lesion and previous observations with noninvasive imaging have detected potential photoreceptor abnormalities and retinal function interplay.

Case Presentation: A 35-year-old woman was found to have an asymptomatic, solitary, circumscribed, pigmented lesion in her left eye. The patient underwent ophthalmic examination including multimodal evaluation with fluorescein angiography, near-infrared reflectance scanning laser ophthalmoscopy, blue autofluorescence, enhanced-depth imaging spectralis B-scan optical coherence tomography (EDI-SBOCT), en face OCT angiography (OCT-A) and microperimetry plus adaptive optics imaging. Read More

Indian J Ophthalmol 2019 Feb;67(2):285-287

Glaucoma Research and Clinical Facility, Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

A 45-year-old diabetic male, with diabetic retinopathy and medically uncontrolled neovascular glaucoma (NVG) underwent intracameral bevacizumab followed by trabeculectomy, with controlled intraocular pressures (IOP) post-operatively, OD: 12 mmHg; OS: 14 mmHg. Patient was referred to hematology, where he was diagnosed as chronic myeloid leukemia (CML) and started on imatinib mesylate. Thereafter, he presented with recurrence of neovascularization and vascularization of the bleb along with OS vitreous hemorrhage at 6 weeks follow-up. Read More

Int J Ophthalmol 2019 18;12(1):51-57. Epub 2019 Jan 18.

Department of Ophthalmology, Ophthalmology & Optometry Center, Peking University People's Hospital, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing 100044, China.

Aim: To evaluate the real-life clinical outcomes of intravitreal injection of conbercept combined rescue therapy for polypoidal choroidal vasculopathy (PCV).

Methods: This was an open label, single center, and interventional study. All enrolled patients were treated initially with three consecutive monthly intravitreal conbercept injections (0. Read More

J Control Release 2019 Feb 17;296:68-80. Epub 2019 Jan 17.

Department of Ophthalmology, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA; Center for Nanomedicine, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA; Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA; Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21231, USA; Departments of Oncology, Neurosurgery, and Pharmacology & Molecular Sciences, The Johns Hopkins University, Baltimore, MD 21231, USA. Electronic address:

Noninfectious uveitis is a potentially blinding ocular condition that often requires treatment with corticosteroids to prevent inflammation-related ocular complications. Severe forms of uveitis such as panuveitis that affects the whole eye often require a combination of topical and either regional or systemic corticosteroid. Regional corticosteroids are currently delivered inside the eye by intravitreal injection (e. Read More

Exp Ther Med 2019 Jan 29;17(1):901-910. Epub 2018 Nov 29.

Department of Ophthalmology, Affiliated Hospital of Qingdao University Medical College, Qingdao, Shandong 266000, P.R. China.

The aim of the present systematic review was to assess the efficacy of laser therapy for ischemic central retinal vein occlusion (CRVO). Relevant studies were retrieved by searching the PubMed, Embase, Chinese Biomedical Literature Database and, Chinese Science and Technology Periodicals databases using a combination of key words, including 'central retinal vein obstruction', 'CRVO', 'laser' and 'panretinal photocoagulation'. The titles, abstracts and full texts were screened by two independent reviewers and studies were selected according to specific inclusion criteria. Read More

Ophthalmic Surg Lasers Imaging Retina 2019 01;50(1):42-49

Background And Objective: To compare between trimanual and unimanual vitrectomy in complicated proliferative diabetic retinopathy (PDR).

Patients And Methods: A prospective, non-randomized, comparative study including patients with tractional retinal detachment (TRD), vitreous hemorrhage with TRD, and combined TRD with rhegmatogenous retinal detachment. The patients were allocated into two groups: the unimanual group with three-port vitrectomy and the trimanual group with added fourth sclerotomy, through which the endoillumination probe was guided by the assistant. Read More