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Retina 2022 Jun;42(6):1103-1110

Division of Ophthalmology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

Purpose: The purpose of this study was to evaluate the prognostic utility of the degree of vitreous attachment for predicting outcomes of vitrectomy for nonclearing vitreous hemorrhage associated with proliferative diabetic retinopathy.

Methods: Medical records of patients who underwent primary vitrectomy for dense nonclearing vitreous hemorrhage secondary to proliferative diabetic retinopathy were examined retrospectively. Eyes were divided into four groups based on the intraoperatively assessed stage of posterior vitreous detachment (PVD), ranging from Stage 0/1 (complete or near-complete vitreoretinal adhesion) to Stage 4 (complete PVD). Read More

Ophthalmol Retina 2022 May 16. Epub 2022 May 16.

California Retina Consultants, Santa Barbara, California.

Purpose: To provide strategies for the management of key ocular adverse events (AEs) that may be encountered with the Port Delivery System with ranibizumab (PDS) in practice, and to provide recommendations that may mitigate such AEs based on clinical trial experience and considerations from experts in the field.

Design: Safety evaluation based on the phase 2 Ladder (NCT02510794) and phase 3 Archway (NCT03677934) trials of the PDS.

Methods: The PDS is a permanent, indwelling, and refillable ocular drug delivery system that requires standardized procedural steps, for its insertion and refill-exchange procedures, which have evolved during the PDS clinical program. Read More

Graefes Arch Clin Exp Ophthalmol 2022 May 19. Epub 2022 May 19.

Department of Ophthalmology, Institute of Vision Research, Severance Hospital, Yonsei University College of Medicine, 50-1, Yonseiro, Seodaemun-gu, Seoul, Republic of Korea.

Purpose: This study aimed to investigate the clinical characteristics of patients with recurrent intraocular lens (IOL) dislocation after scleral-fixated sutured IOL implantation and evaluate the long-term outcomes of scleral re-fixation of IOL.

Methods: The medical records of patients who underwent surgery for IOL dislocation between January 2011 and January 2021 were reviewed. The study included 164 patients (male: 131, female: 33) (176 eyes). Read More

Ophthalmic Surg Lasers Imaging Retina 2022 05 1;53(5):249-256. Epub 2022 May 1.

Objective: To describe the Port Delivery System with ranibizumab implant insertion procedure.

Methods: A surgical procedure based on the clinical trial program in patients with retinal diseases.

Results: An infusion line is placed in the infero-temporal quadrant; a superotemporal quadrant corneal traction suture is recommended. Read More

Eur J Ophthalmol 2022 May 9:11206721221100624. Epub 2022 May 9.

Medical Retina and Vitreoretinal Surgery, University of Pittsburgh School of Medicine, Pittsburg, PA, USA.

Purpose: To compare clinical and imaging features and treatment outcomes between eyes having peripheral polypoidal choroidal vasculopathy (PCV) and macular PCV.

Methods: In this retrospective comparative case series, confirmed cases of peripheral and macular PCV cases on indocyanine green angiography (ICGA) were included. The various demographic features, imaging characteristics and clinical course between cases with peripheral and macular PCV were compared and analysed. Read More

Korean J Ophthalmol 2022 May 6. Epub 2022 May 6.

University of Nebraska Medical Center, Truhlsen Eye Institute, Omaha, NE.

Objective: Various types of trauma can cause retinal hemorrhages (RH) in children, including accidental and non-accidental head trauma. We used animal eyes and a Finite Element (FE) model of the eye to examine stress patterns produced during purely linear and angular accelerations, along with stresses attained during simulated repetitive shaking of an infant.

Methods: Using sheep and primate eyes, sclerotomy windows were created by removing the sclera, choroid, and RPE to expose the retina. Read More

J AAPOS 2022 May 4. Epub 2022 May 4.

Department of Neurology, Perth Children's Hospital, Perth WA Australia; The University of Western Australia.

We present a case of bilateral myelin oligodendrocyte glycoprotein antibody optic neuritis (MOG-ON) with unilateral vitreous hemorrhage in a 6-year-old boy. Multidisciplinary team care, including extensive investigations and prolonged follow-up, excluded alternative causes of vitreous hemorrhage. Early suspicion and diagnosis of MOG-ON led to timely intravenous methylprednisolone treatment, with protracted oral steroid taper, resulting in complete resolution of optic nerve swelling, vitreous hemorrhage, and visual function. Read More

Ther Adv Ophthalmol 2022 Jan-Dec;14:25158414221090099. Epub 2022 Apr 29.

Consultant Ophthalmic and Vitreoretinal Surgeon, Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield University Hospitals NHS Foundation Trust, Glossop Road, Sheffield S10 2JF, UK.

Background: Optimal management of non-diabetic vitreous hemorrhage (NDVH) is controversial, and reliability of B-scan ultrasonography in detecting retinal tears (RTs) has been reported to be highly variable by previous literature.

Objectives: To report outcomes of conservative versus surgical management of NDVH and reliability of B-scan ultrasonography in detecting RTs and rhegmatogenous retinal detachment (RRD).

Design: Retrospective observational single-center cohort study. Read More

Eur J Ophthalmol 2022 May 3:11206721221098880. Epub 2022 May 3.

Ophthalmology Unit, 9370University Hospital of Parma, Parma, Italy.

Purpose: To report a case of possible multi-district thromboembolic event involving the eye of a patient with several cardiovascular risk factors, following a second inoculation of SARS-CoV-2 m-RNA based vaccine.

Case-report: A 60-year-old man presented with blurred vision in the left eye lasting 1 month but started within 24 hours from the 2 dose of BNT162b2 vaccine inoculation. He also reported a long-lasting but self-limiting priapism which started about 4 h after the vaccination. Read More

Retina 2022 Apr 22. Epub 2022 Apr 22.

Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, The Ophthalmology Department, Belfast Health and Social Care Trust.

Purpose: To determine effects of baseline characteristics and laser type performed on outcomes in people with proliferative diabetic retinopathy (PDR) undergoing panretinal photocoagulation (PRP).

Methods: Medical records of all consecutive patients with PDR naïve to PRP, identified using an electronic database, evaluated at the Macula Clinic, Belfast Health and Social Care Trust, receiving their first PRP between 1st January 2016 and 30th June 2017, and followed for a minimum of 6 months following stabilization of PDR, were retrospectively reviewed. Outcomes included time to stabilization following PRP, progression of PDR, and mean change in best-corrected visual acuity from baseline to last follow-up. Read More

Diabetes Metab Syndr Obes 2022 26;15:1293-1303. Epub 2022 Apr 26.

Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

Purpose: To compare the clinical features and vitreous biomarkers of proliferative diabetic retinopathy (PDR) between patients with early-onset and late-onset type 2 diabetes mellitus (T2DM).

Materials And Methods: This case-control study analyzed the clinical data of 74 patients with PDR who underwent vitrectomy. The patients were divided into the early-onset (T2DM diagnosis age ≤ 40 years, n = 39) and late-onset (T2DM diagnosis age > 40 years, n = 35) groups. Read More

Am J Case Rep 2022 Apr 29;23:e936266. Epub 2022 Apr 29.

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

BACKGROUND Chronic myelogenous leukemia (CML) is a malignant myeloproliferative neoplasm of pluripotent stem cell origin. Ophthalmic manifestation as an initial presentation in cases of CML is extremely rare. Frequently, ocular lesions in CML are asymptomatic. Read More

Turk J Ophthalmol 2022 04;52(2):125-138

Ankara University Faculty of Medicine, Department of Ophthalmology, Ankara, Turkey

Surgery in intraocular tumors is done for excision/biopsy and the management of complications secondary to the treatment of these tumors. Excision/biopsy of intraocular tumors can be done via fine-needle aspiration biopsy (FNAB), transretinal biopsy (TRB), partial lamellar sclerouvectomy (PLSU), and endoresection. FNAB, TRB, and PLSU can be used in tumors that cannot be diagnosed by clinical examination and other ancillary testing methods. Read More

Am J Ophthalmol 2022 Apr 22. Epub 2022 Apr 22.

Retinal Disorders and Ophthalmic Genetics, Stein Eye Institute, University of California, Los Angeles, CA, USA; Greater Los Angeles VA Healthcare Center, Los Angeles, CA, USA. Electronic address:

Purpose: To summarize all reported cases of Henle fiber layer (HFL) hemorrhage in the absence of subretinal neovascularization (SRNV) in patients with macular telangiectasia type 2 (MacTel2) and to propose a mechanism for the right sided predominance of this unique presentation.

Design: Perspective METHODS: Collection, review, and analysis of all cases in the literature and in the authors' databases of HFL hemorrhage in MacTel2, including analysis of baseline and follow up multimodal retinal imaging findings of selected cases. Elucidation of the complex interplay of systemic venous pressure with the deep retinal capillary plexus and hypothesis regarding the right-sided predilection of HFL hemorrhage complicating MacTel2. Read More

Am J Ophthalmol Case Rep 2022 Jun 12;26:101514. Epub 2022 Apr 12.

Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Purpose: To report novel life-threatening coronary and systemic arterial disease associated with Retinal Arterial Macroaneurysms with Supravalvular Pulmonic Stenosis (RAMSVPS) syndrome, previously known as Familial Retinal Arterial Macroaneurysms (FRAM).

Observations: A 29-years old woman with longstanding poor vision in her right eye presented with acute myocardial infarction and subclavian bruit. Her polyangiogram showed peculiar ostial coronary aneurysms, left anterior descending coronary artery stenosis, occlusion of the left subclavian artery, stenosis of both renal arteries, irregularities in the mesenteric artery and tapering of the aorta. Read More

Am J Ophthalmol Case Rep 2022 Jun 12;26:101537. Epub 2022 Apr 12.

Francis I. Proctor Foundation, University of California San Francisco, San Francisco, CA, USA.

Purpose: To describe uveitis-glaucoma-hyphema (UGH) syndrome secondary to a posterior chamber intraocular lens (PCIOL) within the capsular bag in which pathogenic changes to the ciliary body were observed and treated with endocyclophotocoagulation (ECP).

Observations: An 85-year-old woman who had cataract surgery in her right eye four years ago presented with recurrent, unilateral, open-angle, hypertensive uveitis in her right eye. Her presentations were characterized by decreased vision, elevated intraocular pressure, corneal edema, a mixed anterior chamber reaction, and pigmented anterior vitreous cells. Read More

Am J Ophthalmol Case Rep 2022 Jun 10;26:101526. Epub 2022 Apr 10.

Department of Ophthalmology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, 200031, China.

Purpose: To describe a patient in whom a pulsating choroidal vascular lesion was observed during vitrectomy for the treatment of vitreous hemorrhage secondary to polypoidal choroidal vasculopathy (PCV).

Observations: A 67-year-old Chinese male was referred to our department for the treatment of vitreous hemorrhage secondary to PCV in his right eye. PCV was confirmed during surgery, accompanied by extensive vitreous and subretinal hemorrhage, and exudation in the posterior pole and temporal to the fovea. Read More

Front Med (Lausanne) 2022 7;9:855661. Epub 2022 Apr 7.

Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Purpose: This study aimed to evaluate the efficacy and complications of intra-arterial chemotherapy (IAC) as a primary treatment for advanced unilateral retinoblastoma in Chinese patients.

Methods: This study was a retrospective review of patients with advanced unilateral retinoblastoma treated with IAC as the primary treatment. The IAC procedures were performed using a balloon-assisted technique. Read More

Retin Cases Brief Rep 2022 Feb 2. Epub 2022 Feb 2.

Retina Consultants of Orange County, Fullerton, CA, 92835.

Purpose: To describe cases of visually significant vitreous hemorrhage (VH) following dexamethasone (DEX) intravitreal implant in our practice and present two cases which required surgical intervention as well as a case of VH and hypotony following DEX implant. We also describe and illustrate an injection technique which may minimize incidence of these complications.

Methods: Retrospective case series. Read More

BMC Ophthalmol 2022 Apr 19;22(1):178. Epub 2022 Apr 19.

Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, Osaka, Japan.

Background: Diagnostic vitrectomy is an important method for evaluating uveitis, and its diagnostic utility is high regardless of whether the uveitis is infectious or non-infectious. The course of diagnostic vitreous surgery with 27-gauge pars plana vitrectomy and perioperative complications is reported.

Methods: An observational retrospective study of patients who underwent 27-gauge diagnostic vitrectomy due to atypical intraocular inflammation was conducted. Read More

Skinmed 2022 28;20(1):69-71. Epub 2022 Feb 28.

Department of Ophthalmology, Vardhaman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.

A 25-year-old man consulted us with a severe exacerbation of pustular psoriasis for 10 days (Figure 1). The patient had pustular psoriasis for the last 12 years. During his hospital stay, he suffered sudden painless and profound loss of vision in both eyes. Read More

Ther Adv Ophthalmol 2022 Jan-Dec;14:25158414221083366. Epub 2022 Apr 12.

Reiyukai Eiko Masunaga Eye Hospital, Banepa, Nepal.

Background: Spontaneous vitreous hemorrhage is one of the common causes of ocular emergency. There are very few prospective studies on the clinical profile and surgical outcomes for patients with dense vitreous hemorrhage caused by non-diabetic and non-traumatic till date to our knowledge.

Objectives: This study was conducted to better understand the etiologies, clinical profile, surgical outcome, and visual prognosis following pars plana vitrectomy for dense vitreous hemorrhage in adults with non-traumatic and non-diabetic retinopathy. Read More

Front Endocrinol (Lausanne) 2022 29;13:807687. Epub 2022 Mar 29.

Affiliated Hospital of Nantong University, Nantong, China.

Objective: To compare the efficacy and safety of panretinal photocoagulation (PRP) combined with intravitreal anti-vascular endothelial growth factor (anti-VEGF) against PRP monotherapy for diabetic retinopathy (DR).

Methods: We searched Pubmed, Cochrane Library, Web of Science, Embase, and Science Direct Register of Controlled Trials from April 2011 to January 2021 to identify the randomized trials that compared the efficacy and safety between PRP combined with intravitreal anti-VEGF and PRP monotherapy for DR. We searched in the following databases between April 2011 and January 2021: Pubmed, Cochrane Library, Web of Science, Embase, and Science Direct without any restriction of countries or article type. Read More

Cureus 2022 Mar 10;14(3):e23049. Epub 2022 Mar 10.

Ophthalmology, Hospital Sultanah Nur Zahirah, Kuala Terengganu, MYS.

We report a rare case of bilateral Idiopathic Retinitis, Vasculitis, Aneurysms, and Neuroretinitis (IRVAN) with occlusive vasculitis. A 28-year-old female presented with sudden decreased vision in her left eye for three days. Visual acuity in the right eye was 6/6, whereas it was 6/9 in the left eye. Read More

Transl Vis Sci Technol 2022 Apr;11(4):11

Kuwait Specialized Eye Center, Kuwait City, Kuwait.

Purpose: We report a case series demonstrating a novel technique to access the subretinal space through a trans-scleral approach.

Methods: This was a prospective, interventional case series. All 25 cases underwent three-port vitrectomy using CONSTELLATION Vision System (Alcon. Read More

Clin Case Rep 2022 Apr 5;10(4):e05683. Epub 2022 Apr 5.

Department of Ophthalmology Tsukazaki Hospital Himeji Japan.

Retinal arterial macroaneurysm shows rapid vision loss when rupture occurs; therefore, preventive photocoagulation should be considered, if necessary. Read More

Int Med Case Rep J 2022 5;15:141-155. Epub 2022 Apr 5.

Department of Ophthalmology, University of Calabar Teaching Hospital, Calabar, Nigeria.

Purpose: To report incidence, clinical presentation, and treatment outcome of full-thickness macular hole (FTMHs) diagnosed post pars plana vitrectomy.

Methods: We retrospectively reviewed the demographics, best-corrected visual acuity (BCVA), indication for the primary vitrectomy, time to diagnose the secondary FTMH, optical coherence tomographic (OCT) appearance, and treatment outcome of FTMHs, occurring after vitrectomy performed between January 2019 and December 2020.

Results: Six of 523 vitrectomized eyes developed FTMHs, an incidence of 1. Read More

Sci Rep 2022 Apr 8;12(1):5942. Epub 2022 Apr 8.

Research Department, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia.

To explore the demographic profiling, causes, types, complications, management outcomes, and severity of fireworks-inflicted ocular injuries in children in KSA. This is a retrospective study of 115 cases with eye injuries managed at the Emergency Department, of our institution between 2003 and 2019. Demography, clinical features at presentation, mode of management and the Best-corrected visual acuity (BCVA) were evaluated at the last follow up. Read More

Front Med (Lausanne) 2022 22;9:833565. Epub 2022 Mar 22.

Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Purpose: To report a case of primary vitreoretinal lymphoma (PVRL) treated with oral zanubrutinib, who had bilateral intraocular hemorrhage after intravitreal injection of methotrexate (MTX).

Case Report: A 69-year-old Chinese female presented with vision decrease in both eyes. After diagnostic vitrectomy, the patient was diagnosed as PVRL in both eyes, and was treated with intravenous rituximab, oral zanubrutinib and bilateral intravitreal MTX. Read More