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Ophthalmic Surg Lasers Imaging Retina 2019 Jan;50(1):42-49

Background And Objective: To compare between trimanual and unimanual vitrectomy in complicated proliferative diabetic retinopathy (PDR).

Patients And Methods: A prospective, non-randomized, comparative study including patients with tractional retinal detachment (TRD), vitreous hemorrhage with TRD, and combined TRD with rhegmatogenous retinal detachment. The patients were allocated into two groups: the unimanual group with three-port vitrectomy and the trimanual group with added fourth sclerotomy, through which the endoillumination probe was guided by the assistant. Read More

JAMA Ophthalmol 2019 Jan 10. Epub 2019 Jan 10.

Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.

Importance: Diabetic retinopathy is the leading cause of blindness in working-age adults. Studies have suggested that statins may reduce the risk of developing diabetic retinopathy.

Objective: To investigate the association between statin therapy and the development of diabetic retinopathy in patients with diabetes and dyslipidemia. Read More

Case Rep Ophthalmol Med 2018 3;2018:9457549. Epub 2018 Dec 3.

Department of Ophthalmology, Drexel University College of Medicine, Philadelphia, PA, USA.

Hyperfractionated cyclophosphamide, vincristine, adriamycin, and dexamethasone (Hyper-CVAD) is an important chemotherapeutic regimen for acute lymphoblastic leukemia (ALL) and non-Hodgkin's lymphoma. We present a case of a 23-year-old male with T-cell ALL and visual acuity of 20/20 in the right eye and 20/25 in the left eye who developed significant changes in his vision after starting Hyper-CVAD therapy. The patient initially presented with cotton wool spots in the fundus shortly after starting the regimen. Read More

Front Bioeng Biotechnol 2018 18;6:199. Epub 2018 Dec 18.

Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States.

The vitreous humor is a fragile, transparent hydrogel situated between the lens and the retina, occupying 80% of the eye's volume. Due to its viscoelastic behavior, the vitreous serves as a mechanical damper for the eye, absorbing impacts, and protecting the lens and retina. The vitreous liquefies with age, which compromises its function as a shock absorber and causes complications including retinal detachment, macular holes, and vitreous hemorrhage. Read More

J Mol Med (Berl) 2019 Jan 7. Epub 2019 Jan 7.

MediCity Research Laboratory, University of Turku, Tykistökatu 6A, 20520, Turku, Finland.

ATP and adenosine are important signaling molecules involved in vascular remodeling, retinal function, and neurovascular coupling in the eye. Current knowledge on enzymatic pathways governing the duration and magnitude of ocular purinergic signaling is incompletely understood. By employing sensitive analytical assays, this study dissected ocular purine homeostasis as a complex and coordinated network. Read More

World Neurosurg 2018 Dec 29. Epub 2018 Dec 29.

Department of Neurosurgery, the First Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, China. Electronic address:

Background: Terson syndrome is a serious complication of subarachnoid hemorrhage includes any intraocular hemorrhage and may result in blurred vision or even blindness. However, it is often overlooked clinically.

Case Description: A 42-year-old man presented with coma due to rupture of a left posterior communicating artery aneurysm. Read More

Clin Ophthalmol 2018 6;12:2519-2534. Epub 2018 Dec 6.

Allergan Plc, Irvine, CA, USA.

Purpose: To evaluate the long-term safety of dexamethasone intravitreal implant (DEX) in patients treated for macular edema associated with retinal vein occlusion (RVO) or noninfectious posterior segment uveitis (NIPSU) in clinical practice.

Patients And Methods: Multicenter (102 sites in France, Germany, Spain, UK), prospective, observational, post-authorization safety study in adult patients treated with DEX. Data collected up to 2 years after enrollment included serious adverse events (SAEs) and adverse events of special interest (AESIs; adverse drug reactions that are considered important risks associated with DEX and listed in the European Union Ozurdex Risk Management Plan). Read More

Int J Retina Vitreous 2018 13;4:46. Epub 2018 Dec 13.

Department of Retina and Vitreous, Aditya Birla Sankara Nethralaya, No. 147, Mukundapur EM By Pass, Near Purva Jadavpur Thana, Kolkata, West Bengal 700099 India.

Background: To describe the multicolour (MC) imaging characteristics associated with choroidal osteomas (CO) and their secondary complications.

Methods: Retrospective descriptive case series of eleven eyes of ten patients with CO. Findings of multicolour imaging were correlated with visual acuity, clinical features, lesion characteristics and findings from other imaging modalities. Read More

BMC Ophthalmol 2018 Dec 17;18(1):327. Epub 2018 Dec 17.

Department of Ophthalmology and Vision Science, Eye and ENT Hospital of Fudan University, 83 Fenyang Rd, Shanghai, 200031, People's Republic of China.

Background: We present a case of intrusion of a suture knot 15 years after scleral buckling surgery.

Case Presentation: A 62-year-old woman with high myopia had undergone scleral buckling surgery in her left eye 15 years previously for rhegmatogenous retinal detachment. She recently displayed highly elevated intraocular pressure, with hyphema and vitreous hemorrhage. Read More

Yonsei Med J 2019 Jan;60(1):65-72

Division of Cardiology, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Antithrombotic therapy could be related with nuisance bleeding. This study investigated whether vitreous hemorrhage (VH) is associated with specific types of antithrombotic medication in patients with atrial fibrillation (AF).

Materials And Methods: In the Korean National Health Insurance Service National Sample Cohort, we identified 9352 antiplatelet/anticoagulant-treated AF patients. Read More

Retina 2018 Dec 6. Epub 2018 Dec 6.

Vitreous, Retina, Macula Consultants of New York, New York.

Purpose: To investigate the imaging characteristics of early Type 3 neovascularization and propose a new pathophysiologic sequence for early disease.

Methods: Patients were evaluated with a comprehensive ophthalmologic examination to include fundus photography, optical coherence tomography, optical coherence tomography angiography, fluorescein angiography, and volume-rendered optical coherence tomography angiography. Relevant literature was also reviewed. Read More

Int J Retina Vitreous 2018 5;4:44. Epub 2018 Dec 5.

1Vitreous Retina Macula Consultants of New York, 460 Park Ave., New York, NY 10022 USA.

Background: Aneurysmal type 1 neovascularization (AT1) is a term recently introduced to better describe the aneurysmal dilatation that may arise from neovascular lesions, more commonly known as polypoidal choroidal vasculopathy. The proposed term, AT1, includes an expanded clinical spectrum of aneurysmal (polypoidal) lesions observed in both different ethnicities and associated with varied clinical phenotypes.

Case Presentation: A 61-year-old woman of European descent was referred for a new, asymptomatic retinal hemorrhage found on routine examination. Read More

Clin Ophthalmol 2018 14;12:2323-2329. Epub 2018 Nov 14.

Department of Ophthalmology, Toho University Sakura Medical Center, Shimoshizu, Sakura, Japan,

Purpose: To investigate the potential risk factors for neovascular glaucoma (NVG) after vitrectomy in eyes with proliferative diabetic retinopathy.

Subjects And Methods: In this retrospective, observational, comparative study, patients with proliferative diabetic retinopathy who underwent vitrectomy at Toho University Sakura Medical Center between December 2011 and November 2016 and who were followed for ≥12 months after surgery were included. Subject parameters examined included age, glycated hemoglobin (HbA1c), fasting blood glucose, administration of insulin, and estimated glomerular filtration rate. Read More

Retin Cases Brief Rep 2018 Nov 28. Epub 2018 Nov 28.

Department of Ophthalmology, Ministry of Education, Key Laboratory of Vision Loss and Restoration, Peking University Third Hospital, Beijing, China.

Purpose: Optic disk astrocytoma is a rare variant of congenital hamartoma, which is usually associated with tuberous sclerosis complex. Generally, it is stationary but in rare cases, it can show progressive growth and cause severe local complications.

Methods: Clinical-pathologic correlation. Read More

Zhonghua Yan Ke Za Zhi 2018 Dec;54(12):918-922

Tianjin Medical University Eye Hospital, College of Optometry and Ophthalmology, Tianjin Medical University Eye Institute, Tianjin 300384, China.

To report the clinical outcomes and safety profile of 27G(+) transconjunctival sutureless vitrectomy (TSV) in eyes with posterior segment disease. Prospective, interventional case series. Eyes undergoing 27G(+) TSV for a vitreoretinal surgery indication were included from Dec 2015 to Mar 2016. Read More

J Coll Physicians Surg Pak 2018 Dec;28(12):919-922

Department of Ophthalmology, Mayo Hospital, Lahore, Pakistan.

Objective: To determine the changes in the retinal nerve fiber layer as measured on optical coherence tomography (OCT) after phacoemulsification with intraocular lens implantation.

Study Design: Quasi-experimental study.

Place And Duration Of Study: Department of Ophthalmology, Lahore General Hospital, Lahore, from March 2017 to April 2018. Read More

Am J Ophthalmol Case Rep 2019 Mar 11;13:41-45. Epub 2018 Nov 11.

Retina Department, Asociación para Evitar la Ceguera en México, Hospital "Dr. Luis Sánchez Bulnes" IAP, Mexico City, Mexico.

Purpose: To report a case of occlusive retinal vasculopathy, secondary to hyperhomocysteinemia.

Observations: A 43-year-old male was examined at the retina outpatient clinic due to complaints of bilateral decrease in visual acuity. The patient underwent a comprehensive ophthalmological examination, wide-field fundus photographs and fluorescein angiography, as well as spectral domain optical coherence tomography with enhanced-deep imaging. Read More

Int Med Case Rep J 2018 30;11:293-296. Epub 2018 Oct 30.

Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan,

We experienced a case of sympathetic ophthalmia in a fellow eye after vitrectomy for subretinal hemorrhage related to polypoidal choroidal vasculopathy. A 60-year-old male consulted us for polypoidal choroidal vasculopathy with subretinal hemorrhage in his left eye. The recurrence of massive subretinal hemorrhage refractory to repeated pars plana vitrectomies leads to phthisis bulbi. Read More

Ophthalmic Surg Lasers Imaging Retina 2018 Nov;49(11):893-896

Since the publication of BEAT-ROP in 2011, intravitreal bevacizumab (IVB) has become increasingly common for the treatment of posterior type 1 retinopathy of prematurity (ROP). However, long-term data on the safety and efficacy of IVB for ROP are lacking. Vitreous hemorrhage following bevacizumab injections have been rarely reported in infants with ROP, and the need for treatment of these hemorrhages remains in question. Read More

Eur J Ophthalmol 2018 Nov 14:1120672118811980. Epub 2018 Nov 14.

Department of Ophthalmology, Horngren Family Vitreoretinal Center, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.

Introduction:: To evaluate the adverse event rate following pars plana vitrectomy as a function of surgical start time and the presence of a vitreoretinal fellow.

Methods:: Single-institution retrospective cohort study of patients undergoing pars plana vitrectomy from 1 January 2016 to 31 December 2016 at Stanford University School of Medicine (Palo Alto, CA, USA). Records were reviewed for surgical start time, the presence of vitreoretinal fellow, and postoperative adverse events defined as any finding deviating from the expected postoperative course requiring observation or intervention. Read More

Clin Ophthalmol 2018 23;12:2145-2148. Epub 2018 Oct 23.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL 33136, USA,

Purpose: To report the visual outcomes and complications of scleral fixated intraocular lenses (IOLs) using Gore-Tex suture.

Methods: The current study is a retrospective noncomparative case series including patients who underwent scleral fixation of IOL (Akreos AO60) using Gore-Tex suture from August 2015 to March 2017 at a university teaching center. Primary outcome measures were visual acuity and complications at last follow-up. Read More

Ophthalmic Genet 2018 Dec 8;39(6):754-758. Epub 2018 Nov 8.

a Retinal Consultants , Des Plaines , IL , USA.

Background: Loeys-Dietz syndrome (LDS) is a connective tissue disorder that has phenotypic overlap with Marfan syndrome. In LDS, the aortic root dissections can be more aggressive and occur at a younger age than Marfan syndrome.

Materials And Methods: Review of two cases. Read More

Ophthalmic Surg Lasers Imaging Retina 2018 Oct;49(10):e161-e164

Beta-thalassemia (β-thalassemia) minor is characterized by a mutation in one of the two β-globin genes (HBB) that produce the β-globin chains in the hemoglobin molecule. Although other hemoglobinopathies have been frequently associated with retinal disease, there are limited reports of retinal pathology with β-thalassemia minor. We report two patients with β-thalassemia minor presenting with decreased vision, vitreous hemorrhage, and proliferative retinopathy. Read More

Ophthalmic Surg Lasers Imaging Retina 2018 Oct;49(10):e129-e134

Background And Objective: To compare the visual outcome and complications of two different sutureless scleral-fixated intraocular lens (IOL) implantation techniques, that is, intrascleral IOL fixation technique and modified Yamane's technique of scleral fixation of IOL.

Patients And Methods: Patients who underwent scleral fixation of IOL (SFIOL) from June 2015 to February 2017 with more than 6 months of follow-up were examined retrospectively. Improvement in visual acuity (VA), intraocular pressure (IOP) measurements, endothelial cell count, central macular thickness (CMT), and intraoperative/postoperative complications were compared at 6 months follow-up. Read More

Med Hypothesis Discov Innov Ophthalmol 2018 ;7(3):122-125

Department of Ophthalmology, University of Health Sciences, Ankara Ulucanlar Eye Education and Research Hospital, Ankara, Turkey.

Sildenafil is one of the most commonly used drugs for sexual dysfunction or to increase libido, and it regulates endothelial nitric oxide synthase enzyme via selective phosphodiesterase-V inhibition. Sildenafil can be easily obtained without a medical indication or prescription yet it is not considered as a completely safe medication. Hemoptysis and hemorrhagic stroke are some important adverse effects of sildenafil. Read More

BMC Ophthalmol 2018 Oct 30;18(1):283. Epub 2018 Oct 30.

Department of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Lab, 1 Dongjiaominxiang, Dongcheng District, Beijing, 100730, China.

Background: Universal ocular screening of infants is not a standard procedure in children's health care system in China. This pilot study investigated prevalence of ocular abnormalities of 6 weeks-age infants using wide-field digital imaging system.

Methods: Infants aged 6 weeks around were consecutively enrolled in a public hospital between April 2015 and August 2016. Read More

Retina 2018 Oct 23. Epub 2018 Oct 23.

Bausch & Lomb, Inc, Irvine, California.

Purpose: Investigate the effective performance and safety of a new hypersonic vitrector technology.

Methods: Postapproval, prospective, single-arm, noncomparative, open-label study at one clinical site in India.

Indications: macular hole (9/20), vitreous hemorrhage (7/20), vitreomacular traction (3/20), and vitreomacular traction with pseudomacular hole (1/20). Read More

Retina 2018 Oct 22. Epub 2018 Oct 22.

Vitreous Retina Macula Consultants of New York, New York, New York.

Purpose: To describe patterns of hypoautofluorescence in eyes with neovascular age-related macular degeneration occurring after subretinal hemorrhage.

Methods: This was a retrospective descriptive analysis of neovascular age-related macular degeneration eyes presenting with subretinal hemorrhage over the last 5 years that underwent serial multimodal imaging. A review of color fundus photographs, fundus autofluorescence, near-infrared reflectance, and optical coherence tomography was performed at baseline and all available follow-up visits to document the course and evolution of subretinal hemorrhage in these eyes. Read More

Indian J Ophthalmol 2018 Nov;66(11):1640-1642

Department of Textile Technology, Indian Institute of Technology, New Delhi, India.

A 36-year-old male presented with history of injury in the left eye 3 years back with a copper wire. Examination revealed the presence of typical sunflower cataract with golden yellow deposits over the anterior lens capsule with dull glow and old vitreous hemorrhage. Non-contrast computerized tomography revealed retained intraocular foreign body in the pars plana region. Read More

Indian J Ophthalmol 2018 Nov;66(11):1631-1633

Department of Ophthalmology, Grant Medical College and Sir J.J. Group of Hospital, Mumbai, Maharashtra, India.

Dengue is a mosquito-borne infection endemic in the tropical and subtropical regions of the world. Classic dengue fever is a self-limiting, influenza-like illness transmitted by Aedes aegypti mosquito. Ophthalmic manifestations though rare can involve both the anterior and posterior segments and are usually associated with the thrombocytopenic state. Read More

JAMA Ophthalmol 2018 Dec;136(12):1391-1397

Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia.

Importance: Adding a laser-induced chorioretinal anastomosis (L-CRA) to current treatments for central retinal vein occlusion (CRVO) may improve outcomes and lessen therapy burdens.

Objective: To determine the 2-year efficacy of intravitreal ranibizumab with an L-CRA vs ranibizumab alone for patients with macular edema caused by CRVO.

Design, Setting, And Participants: In this randomized clinical trial conducted at a single university clinic from March 2012 to June 2015, 58 participants with macular edema caused by CRVO were randomized 1:1 to either an L-CRA or sham procedure at baseline. Read More

J Fr Ophtalmol 2018 Nov 17;41(9):852-856. Epub 2018 Oct 17.

Centre hospitalier Lucien-Hussel-Vienne, montée du Dr Chapuis, 38200 Vienne, France; Centre pôle vision Val d'Ouest, Clinique du Val d'Ouest, 39, chemin de-la-Vernique, 69130 Ecully, France. Electronic address:

Purpose: To assess the feasibility and acceptability of outpatient care without next-day examination for patients undergoing retinal surgery.

Methods: Patients undergoing ambulatory vitreoretinal surgery between November 2013 and February 2016 at the Vienna medical center were included in this retrospective study. The age, comorbidities, indication, surgical technique and type of anesthesia used, symptoms, intraocular pressure and biomicroscopic examination data at the D0, D7 and M1 visits were recorded. Read More

J Med Case Rep 2018 Oct 17;12(1):310. Epub 2018 Oct 17.

Opticlass, Coriolan Brediceanu no. 29, Timisoara, Romania.

Background: Eales' disease is a difficult to treat idiopathic form of retinal vasculitis. We present such a case with peculiar epidemiology in which the only efficient therapeutic approach in order to maintain functional vision was repeated intravitreal dexamethasone implants (Ozurdex®). To the best of our knowledge this is the first report of this kind in the literature. Read More

Curr Eye Res 2018 Oct 12:1-7. Epub 2018 Oct 12.

a Department of Ophthalmology , Gachon University Gil Hospital , Incheon , Korea.

Purpose: To demonstrate the advantages and efficacy of an air-perfused membrane dissection to control intraoperative bleeding in 23-gauge sutureless vitrectomy for proliferative diabetic retinopathy with severe fibrovascular membranes. Meterials and Methods: A prospective, consecutive, interventional case series of 15 eyes that underwent air-perfused diabetic vitrectomy (air vitrectomy group) for removal of the membranes was compared with a retrospective, membrane-matched case series of 10 eyes that underwent conventional diabetic vitrectomy (conventional vitrectomy group). The main outcome measures were real vitrectomy time, intraoperative and postoperative complications, and anatomic and functional successes at the final examination. Read More

Retina 2018 Oct 8. Epub 2018 Oct 8.

Retina and Vitreous Department, Institut Català de Retina, Barcelona, Spain.

Purpose: To compare outcomes in dense vitreous hemorrhage versus mild vitreous hemorrhage due to nontraumatic posterior vitreous detachment.

Methods: We compared 315 eyes, divided into 2 patient groups, one with dense and the other with mild vitreous hemorrhage. The main outcome measures were final mean best-corrected visual acuity, number of retinal tears, number of retinal detachments, and the number of pars plana vitrectomy and/or scleral buckle surgeries. Read More

Curr Eye Res 2018 Oct 9:1-6. Epub 2018 Oct 9.

a Department of Retina Center , Affiliated Eye Hospital of Wenzhou Medical University , Hangzhou , Zhejiang Province , China.

Purpose: To evaluate the feasibility and utility of intraoperative optical coherence tomography (iOCT) during pars plana vitrectomy (PPV) surgery for dense vitreous hemorrhage (VH).

Methods: A retrospective, consecutive, interventional case series. A total of 68 dense VH patients (71 eyes) were enrolled, and the patients were divided into two groups. Read More

Int Ophthalmol 2018 Oct 4. Epub 2018 Oct 4.

Department of Ophthalmology, Nihon University Hospital, 1-6 Surugadai, Kanda, Chiyodaku, Tokyo, 101-8309, Japan.

Purpose: To compare postoperative outcomes of 27-gauge (G) and 25-G vitrectomy conducted as day surgery for proliferative diabetic retinopathy (PDR).

Methods: One hundred eighty-five consecutive PDR patients (185 eyes) who underwent primary vitrectomy (27-G in 64 eyes, 25-G in 121 eyes) were analyzed.

Results: The 27-G and 25-G groups did not differ significantly in preoperative Early Treatment Diabetic Retinopathy Study (ETDRS) score, age, or preoperative intraocular pressure. Read More

J Contemp Brachytherapy 2018 Aug 31;10(4):347-359. Epub 2018 Aug 31.

Intraocular Tumor Unit, Hospital Universitario de Valladolid, Valladolid.

Purpose: To assess the influence of the radiobiological doses, tumor, and treatment features on retinopathy, cataracts, retinal detachment, optic neuropathy, vitreous hemorrhage, and neovascular glaucoma at the authors' institution after brachytherapy for posterior uveal melanoma.

Material And Methods: Medical records of 243 eyes with uveal melanoma, treated by iodine brachytherapy between 1996 and 2016 at a single center were analyzed. Clinical and radiotherapy data were extracted from a dedicated database. Read More

Neuropediatrics 2018 Sep 20. Epub 2018 Sep 20.

Department of Neonatology, UCL EGA Institute for Women's Health (IfWH), University College London, London, United Kingdom.

Background And Aim:  Perinatal HI (hypoxia-ischemia)-related visual defects including blindness are known to be associated with ischemic lesions in intracerebral visual pathways and ischemic retinal damage (IRD). Intraocular hemorrhages (IOH) such as retinal hemorrhage (RH), which may result from perinatal HI, can cause IRD by various mechanisms. We aimed to evaluate the early retinal findings in neonates with moderate-to-severe neonatal encephalopathy (NE) who underwent TH and its relationship between coagulation status, amplitude-integrated electroencephalography (aEEG) patterns, and magnetic resonance imaging-magnetic resonance spectroscopy (MRI-MRS) findings. Read More

J Ophthalmol 2018 29;2018:3212740. Epub 2018 Aug 29.

Department of Vitreo-Retinal Services, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, 1 Anna Nagar, Madurai, Tamil Nadu 625020, India.

Aim: This paper aims at evaluating refractive outcome and complication profile of sutureless, glueless, flapless, intrascleral fixation of intraocular lens (SFIOL) in pediatric population.

Methods: This retrospective study included patients ≤18 years of age who underwent SFIOL for ectopia lentis. Details obtained included preoperative uncorrected visual acuity (UCVA), cycloplegic refraction, and best-corrected visual acuity (BCVA); intraoperative complications; and postoperative UCVA, cycloplegic refraction, and BCVA and complications. Read More

Int J Ophthalmol 2018 18;11(9):1550-1554. Epub 2018 Sep 18.

Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute, Ophthalmology College of Tianjin Medical University, Tianjin 300384, China.

Diabetic retinopathy (DR) is one of the most important types of diabetic microangiopathy, which is a specific change of fundus lesions and is one of the most serious complications of diabetes. When DR develops to proliferative DR, the main factors of decreasing vision, and even blindness, include retinal detachment and vitreous hemorrhage caused by contraction of blood vessels by fiber membrane. Recent studies reported that the formation of fiber vascular membrane is closely related to retinal fibrosis. Read More

Ophthalmic Surg Lasers Imaging Retina 2018 Sep;49(9):e83-e88

The authors report three cases of persistent fetal vasculature (PFV) presenting with an atypical peripheral fibrovascular stalk. A 5-month-old with congenital exotropia with a vitreous hemorrhage in the right eye underwent vitrectomy, and a mid-peripheral vitreal vascular stalk was visualized within the area of hemorrhage. The second case is of an 8-year-old with two fetal vascular remnants in the right eye: (1) a stalk superotemporally extending from the pars plana to the mid-peripheral retina that was associated with a retinal break and (2) a focal lens opacity. Read More

Ophthalmic Surg Lasers Imaging Retina 2018 Sep;49(9):e44-e51

Background And Objective: To evaluate the correlation between pars plana incision and transient hypotony after silicone oil removal in aphakic eyes PATIENTS AND METHODS:Twenty-two patients with aphakia and a high degree of myopia with silicone oil tamponade were recruited for this prospective study and randomly scheduled to two groups for silicone oil removal: 3.5-mm corneal incision with suture corneal or 20-gauge pars plana incision with suture. Intraocular pressure (IOP) was measured and fundus and anterior structure were examined preoperatively on the first, third, and seventh postoperative day and at 1 month after surgery. Read More

Ophthalmic Genet 2018 Dec 17;39(6):749-753. Epub 2018 Sep 17.

a Departments of Ophthalmology , Mayo Clinic , Rochester , MN , USA.

Background: To report a 68-year-old female with an autosomal-dominant vitreoretinochoroidopathy (ADVIRC) phenotype associated with a subretinal hemorrhage (SRH) and novel BEST1 pathogenic variation p.Met571Thr.

Materials And Methods: The patient was assessed by fundus photography, fluorescence and indocyanine green angiography, spectral-domain optical coherence tomography, photopic and scotopic electroretinogram (ERG), and electrooculogram (EOG). Read More

Retina 2018 Sep 7. Epub 2018 Sep 7.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Purpose: To determine whether treatment order affects ophthalmic vascular event rates after intra-arterial chemotherapy (IAC) for retinoblastoma.

Methods: Patients who received IAC as primary or secondary treatment for retinoblastoma from January 2009 to January 2018 were included. All eyes were imaged with fundus photography and fluorescein angiography. Read More

J Curr Ophthalmol 2018 Sep 21;30(3):276-279. Epub 2018 Jun 21.

Manchester Royal Eye Hospital, Manchester University Hospital NHS Foundation Trust, Manchester, UK.

Purpose: To demonstrate the effect of intravitreal bevacizumab (IVB) on the size and vascularity of the fibro-vascular complex with the optical coherence tomography angiography (OCTA) before pars plana vitrectomy (PPV).

Methods: Observational case series of three eyes with active diabetic fibro-vascular complex and tractional retinal detachment (TRD) who underwent IVB (1.25 mg/0. Read More

Drugs Context 2018 13;7:212532. Epub 2018 Aug 13.

Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.

Diabetes is a major cause of visual impairment among working-age adults in the United States. The proliferative form of diabetic retinopathy is associated with severe vision loss (acuity <5/200). The standard treatment in proliferative diabetic retinopathy (PDR) is panretinal photocoagulation (PRP), which is effective but has established side effects such as peripheral visual-field constraints. Read More

Clin Ophthalmol 2018 22;12:1505-1510. Epub 2018 Aug 22.

Children's Hospital and Medical Center, Omaha, NE, USA,

Purpose: Child abuse is a leading cause of death in infants, which is often associated with abusive head trauma (AHT). The purpose of this retrospective analysis was to identify ocular and systemic findings in confirmed cases of AHT and compare them to a group of non-abusive head trauma (NAHT) patients.

Patients And Methods: A retrospective chart review of 165 patients with accidental and non-accidental trauma admitted between 2013 and 2015 to Children's Hospital and Medical Center in Omaha, NE, USA, was performed. Read More

Am J Ophthalmol 2018 Dec 23;196:82-90. Epub 2018 Aug 23.

Retina Service, Department of Ophthalmology, University of California, San Francisco, San Francisco, California, USA.

Purpose: To evaluate trends for rhegmatogenous retinal detachment (RRD) repair and the influence of patient characteristics on repair type in a large US population including children and adults, between 2003 and 2016.

Design: Retrospective cohort study.

Methods: Setting: Administrative claims for beneficiaries in a large nationwide managed-care network, including Medicare Advantage, employer-sponsored, and commercial insurance. Read More