80,077 results match your criteria Hemolytic Anemia


Nephrotic syndrome associated with primary atypical hemolytic uremic syndrome.

J Bras Nefrol 2020 Aug 10. Epub 2020 Aug 10.

University Corporation Antonio Jose de Sucre, Sincelejo, Sucre, Colombia.

Primary atypical hemolytic-uremic syndrome is a rare disease characterized by non-immune microangiopathic hemolytic anemia, thrombocytopenia, and renal dysfunction; it is related to alterations in the regulation of the alternative pathway of complement due to genetic mutations. The association with nephrotic syndrome is unusual. We present here a pediatric patient diagnosed with primary atypical hemolytic-uremic syndrome associated with nephrotic syndrome who responded to eculizumab treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/2175-8239-JBN-2020-0050DOI Listing

Anesthetic considerations for patients with the Kasabach-Merritt phenomenon.

Paediatr Anaesth 2020 Aug 10. Epub 2020 Aug 10.

Department of Anesthesiology, Perioperative and Pain Medicine, Texas Children's Hospital, Houston, Texas, USA.

The Kasabach-Merritt phenomenon is a rare, life threatening condition characterized by a consumptive coagulopathy resulting in thrombocytopenia, hypofibrinogenemia, hemolytic anemia, and clotting factor deficiencies(1)with mortality rates as high as 30%(1). The Kasabach-Merritt phenomenon is a consumptive coagulopathy that can accompany certain highly vascular tumors which often present during the neonatal period and may involve the head and neck potentially obstructing the airway. However, treatment of coagulopathy can increase tumor burden and should be carefully considered. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pan.13992DOI Listing

Atypical Hemolytic Uremic Syndrome Associated With Clostridium Difficile Infection.

Cureus 2020 Jul 5;12(7):e9005. Epub 2020 Jul 5.

Internal Medicine, Sheikh Zayed Hospital, Lahore, PAK.

Atypical hemolytic uremic syndrome (aHUS), defines as non-Shiga toxin HUS, is thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, consumptive thrombocytopenia, and renal impairment. aHUS is associated with high morbidity and mortality, necessitating the need for an early diagnosis to limit target organ damage. Mutations or autoantibodies against specific complement factors over-activate the complement system forming microthrombi. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.9005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402547PMC

A Rare Case of Acquired Hemolytic Anemia and Pancytopenia Secondary to Pernicious Anemia.

Case Rep Oncol 2020 May-Aug;13(2):783-788. Epub 2020 Jul 2.

Department of Hematology, National Centre for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.

The commonest etiologies of new-onset pancytopenia are congenital bone marrow failure syndromes, marrow space-occupying lesions, infections, and peripheral destruction. Nutritional deficiencies, including folate and vitamin B12, can occasionally cause pancytopenia. We report a 48-year-old gentleman who presented with a 1-week history of dizziness and upper gastrointestinal bleeding. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000507981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383151PMC

Sirolimus is effective for primary relapsed/refractory autoimmune cytopenia: a multicenter study.

Exp Hematol 2020 Aug 6. Epub 2020 Aug 6.

Department of Hematology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

Autoimmune cytopenia includes autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP) and Evans syndrome (ES) caused by abnormal activation of autoimmunity, and shows a considerable refractory/relapse rate. To evaluate the efficacy and toxicities of sirolimus on primary relapsed/refractory autoimmune cytopenia, 45 patients with primary relapsed/refractory AIHA, ES or ITP were collected from October 2016 to January 2019 in 2 institutions, with 3 pediatric patients and 42 adult patients. The median age at diagnosis was 31 (1-84) years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exphem.2020.08.001DOI Listing

Red blood cell alloimmunization prevalence and hemolytic disease of the fetus and newborn in Israel: A retrospective study.

Transfusion 2020 Aug 8. Epub 2020 Aug 8.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Hemolytic disease of the fetus and newborn (HDFN) is a severe form of anemia caused by maternal antibodies against fetal red blood cells (RBC) that can cause intrauterine and perinatal morbidity and mortality. The prevalence and specificities of alloantibodies among Israeli pregnant women and clinical outcomes for their fetuses and newborns are unknown.

Study Design And Methods: A retrospective study of women who gave birth between January 1, 2011, and December 31, 2011, was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/trf.15987DOI Listing

Culture-Proven Disseminated and Meningeal Histoplasmosis Presenting as Septic Shock and Autoimmune Hemolytic Anemia in an Infant.

Cureus 2020 Jul 1;12(7):e8945. Epub 2020 Jul 1.

Pediatric Infectious Diseases, Hospital Nacional De Niños "Dr. Carlos Sáenz Herrera", San José, CRI.

Disseminated histoplasmosis is the most common clinical presentation of histoplasmosis in human immunodeficiency virus (HIV) negative infants from Costa Rica and Latin America. Initial presentation as septic shock and autoimmune hemolytic anemia is uncommon. Even more, detection of by culture in peripheral blood and cerebrospinal fluid (CSF) is extremely rare. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.8945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398712PMC

The Relevance of the MCP Risk Polymorphism to the Outcome of aHUS Associated With C3 Mutations. A Case Report.

Front Immunol 2020 16;11:1348. Epub 2020 Jul 16.

Centro de Investigaciones Biológicas Margarita Salas and Ciber de Enfermedades Raras, Madrid, Spain.

Thrombotic microangiopathy (TMA) has different etiological causes, and not all of them are well understood. In atypical hemolytic uremic syndrome (aHUS), the TMA is caused by the complement dysregulation associated with pathogenic mutations in complement components and its regulators. Here, we describe a pediatric patient with aHUS in whom the relatively benign course of the disease confused the initial diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2020.01348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381106PMC

Leaf and root bark extracts of Ziziphus abyssinica Hochst ex. A. Rich (Rhamnaceae) ameliorate hepatic, renal and splenic injuries induced by phenylhydrazine in rats.

J Basic Clin Physiol Pharmacol 2020 Aug 3. Epub 2020 Aug 3.

Department of Pharmacology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.

Objectives Ziziphus abyssinica (ZA) is employed in managing several ailments in Traditional African Medicine. Scientific evaluations are necessary to ascertain the medicinal potential of ZA as a source of new drug molecules. This study investigated the possible therapeutic benefit of ZA leaf (ZAL) and root bark (ZARB) extracts in an experimental model of multi-organ injuries induced by phenylhydrazine (PHZ). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/jbcpp-2020-0111DOI Listing

Pediatric Hypereosinophilia, Liver Disfunction, and Hemolytic Anemia with Autoimmune Differential.

J Appl Lab Med 2020 Apr 30. Epub 2020 Apr 30.

Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jalm/jfaa035DOI Listing

[Successful management of cold agglutinin syndrome developing subsequent to rheumatoid arthritis with immunosuppressive therapy].

Rinsho Ketsueki 2020 ;61(7):740-744

Department of Gastroenterology, Chikamori Hospital.

A 58-year-old man was admitted with shortness of breath in September 2019. He had a severe hemolytic anemia with a high cold agglutinin (CA) titer. He also had arthralgia and finger deformation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11406/rinketsu.61.740DOI Listing
January 2020

Allopurinol: Sorrow to the marrow.

J Family Med Prim Care 2020 May 31;9(5):2511-2513. Epub 2020 May 31.

Department of General Medicine, JJM Medical College, Davanagere, Karnataka, India.

Allopurinol is a xanthine oxidase inhibitor used in management of chronic gout. It acts by reducing the amount of uric acid by inhibiting purine metabolism. A middle-aged hypertensive female who was on allopurinol for 7 months presented with generalized weakness and exertional dyspnea. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jfmpc.jfmpc_249_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380764PMC

Dapsone-Induced Hemolytic Anemia in Multiple Myeloma: Case Report of Various Differential Diagnoses.

Clin Lymphoma Myeloma Leuk 2020 Jul 2. Epub 2020 Jul 2.

Department of Medicine I (Hematology, Oncology, and Stem Cell Transplantation), Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clml.2020.06.021DOI Listing

Primary Human Derived Blood Outgrowth Endothelial Cells: An Appropriate In Vitro Model to Study Shiga Toxin Mediated Damage of Endothelial Cells.

Toxins (Basel) 2020 Jul 29;12(8). Epub 2020 Jul 29.

Cell Biology Program, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.

Hemolytic uremic syndrome (HUS) is a rare disease primarily characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. Endothelial damage is the hallmark of the pathogenesis of HUS with an infection with the Shiga toxin (Stx) producing (STEC-HUS) as the main underlying cause in childhood. In this study, blood outgrowth endothelial cells (BOECs) were isolated from healthy donors serving as controls and patients recovered from STEC-HUS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins12080483DOI Listing

Differential red blood cell age fractionation and Band 3 phosphorylation distinguish two different subtypes of warm autoimmune hemolytic anemia.

Transfusion 2020 Aug 4. Epub 2020 Aug 4.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

Warm autoimmune hemolytic anemia (wAIHA) is a blood disorder characterized by the increased destruction of autologous red blood cells (RBCs) due to the presence of opsonizing pathogenic autoantibodies. Preliminary reports published more than three decades ago proposed the presence of two wAIHA subtypes: Type I, in which autoantibodies preferentially recognize the oldest, most dense RBCs; and Type II, characterized by autoantibodies that show no preference.

Study Design And Methods: We evaluated patients having wAIHA for Type I and II subtype using discontinuous Percoll gradient age fractionation and direct antiglobulin test (DAT). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/trf.15911DOI Listing

Two cases of idiopathic steroid-resistant nephrotic syndrome complicated with thrombotic microangiopathy.

BMC Nephrol 2020 Aug 3;21(1):323. Epub 2020 Aug 3.

Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.

Background: Thrombotic microangiopathy (TMA) is a histopathological entity associated with microangiopathic hemolytic anemia, thrombocytopenia, and end-organ ischemic damage. Although TMA is caused by various diseases, there have been few reports regarding children with idiopathic nephrotic syndrome (NS) and TMA. Here we report two 1-year-old infants with steroid-resistant NS (SRNS) who presented with severe hypertension, acute kidney injury (AKI), and TMA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-020-01985-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398381PMC

A cysteine protease of Babesia microti and its interaction with tick cystatins.

Parasitol Res 2020 Aug 1. Epub 2020 Aug 1.

Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China.

Babesiosis is a tick-borne protozoonosis caused by Babesia, which can cause fever, hemolytic anemia, hemoglobinuria, and even death. Babesia microti is a parasite found in rodents and can be pathogenic to humans. In this study, the full-length cDNA of a B. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00436-020-06818-wDOI Listing

Coombs-negative hemolytic anemia and elevated plasma hemoglobin levels in COVID-19.

Ann Hematol 2020 Aug 1. Epub 2020 Aug 1.

Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, 1468 Madison Ave, New York, NY, 10029, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00277-020-04202-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395213PMC

National Trends and Outcomes of Nonautoimmune Hemolytic Anemia in Alcoholic Liver Disease: Analysis of the Nationwide Inpatient Sample.

J Clin Gastroenterol 2020 Jul 29. Epub 2020 Jul 29.

Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN.

Goal: The aim of this study was to determine the burden of nonautoimmune hemolytic anemia (NAHA) in hospitalized patients with coexisting alcoholic liver disease (ALD), identify risk factors for NAHA in ALD and describe the hospitalization outcomes.

Background: ALD can result in structural and metabolic alterations in the red-blood cell membrane leading to premature destruction of erythrocytes and hemolytic anemia of varying severity.

Study: Hospitalized ALD patients with concomitant NAHA were identified in the Nationwide Inpatient Sample database using International Classification of Diseases-9 codes from 2009 to 2014. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MCG.0000000000001383DOI Listing

Common variable immunodeficiency with granulomatous-lymphocytic interstitial lung disease and preceding neurological involvement: a case-report.

BMC Pulm Med 2020 Jul 31;20(1):205. Epub 2020 Jul 31.

Department of Respiratory Medicine, Aintree Chest Centre, Liverpool University Hospitals NHS Foundation Trust, Liverpool, L9 7AL, UK.

Background: Common variable immunodeficiency (CVID) is a group of heterogeneous primary immunodeficiencies characterised by a dysregulated and impaired immune response. In addition to an increased susceptibility to infection, it is also associated with noninfectious autoimmune and lymphoproliferative complications. CVID is rarely associated with neurological complications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01231-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393898PMC

Nephrotic-range proteinuria and central nervous involvement in typical hemolytic uremic syndrome: a case report.

BMC Nephrol 2020 Jul 31;21(1):319. Epub 2020 Jul 31.

Department of Nephrology, Peking Union Medical College Hospital, Beijing, 100730, People's Republic of China.

Background: Hemolytic uremic syndrome (HUS), a common subtype of thrombotic microangiopathy (TMA), is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. Shiga toxin-producing Escherichia coli infection is the most common cause of post-diarrheal HUS. Kidney and central nervous system are the primary target organs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-020-01979-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395335PMC

Spontaneous Retroperitoneal Hemorrhage in Dermatomyositis.

Am J Med 2020 Jul 28. Epub 2020 Jul 28.

Department of Medicine, University of Montreal, Division of General Internal Medicine, Centre Hospitalier de l'Université de Montréal.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjmed.2020.06.038DOI Listing

Association between inosine triphosphatase rs1127354 polymorphisms and ribavirin-induced anaemia and outcome in hepatitis C virus-infected patients: A meta-analysis.

J Clin Pharm Ther 2020 Jul 31. Epub 2020 Jul 31.

Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

What Is Known And Objectives: The association between inosine triphosphatase (ITPA) rs1127354 polymorphisms in HCV-infected patients receiving ribavirin (RBV)-based therapy, and the risk of adverse drug reaction and outcomes is still unclear. A meta-analysis was conducted to summarize and clarify this association systematically.

Methods: A comprehensive search was performed in PubMed, Embase and Web of Sciences, and twenty-two studies were selected from the literature search. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcpt.13232DOI Listing

Peripheral haemophagocytosis: a paediatric series.

Authors:
Anselm C Lee

Br J Haematol 2020 Jul 30. Epub 2020 Jul 30.

Children's Haematology and Cancer Centre, Mount Elizabeth Hospital, Singapore City, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjh.16990DOI Listing

[Lymphadenopathies in patients with rheumatic diseases. Review of 19 cases].

Rev Med Chil 2020 Mar;148(3):320-326

Sección de Reumatología, Servicio de Medicina, Hospital del Salvador, Santiago, Chile.

Background: The presence of multiple lymphadenopathies can be a diagnostic challenge.

Aim: To describe the clinical, laboratory and imaging characteristics of 19 patients with lymphadenopathies of rheumatologic origin.

Material And Methods: Review of medical records of 19 patients aged 16 to 72 years (68%) with lymphadenopathies presumably secondary to a rheumatic disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4067/S0034-98872020000300320DOI Listing

Hypertensive emergency presenting with diffuse alveolar hemorrhaging and thrombotic microangiopathy: A case report and review of the literature.

Clin Nephrol Case Stud 2020 27;8:53-61. Epub 2020 Jul 27.

Department of Nephrology and Rheumatology, Aichi Medical University, Nagakute, Japan.

There are few studies reporting diffuse alveolar hemorrhage (DAH) caused by hypertensive emergency. We describe a 41-year-old man who visited the emergency room with hemoptysis and dyspnea. He had a 5-year history of hypertension, though he had not received any treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5414/CNCS109939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386058PMC

Rituximab-containing therapy for cold agglutinin disease: a retrospective study of 16 patients.

Sci Rep 2020 Jul 29;10(1):12694. Epub 2020 Jul 29.

Department of Haematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.

Cold agglutinin disease (CAD) is a rare form of autoimmune haemolytic anaemia, and because of its rareness, there is no standard treatment for CAD patients. We retrospectively analysed the response to rituximab-containing therapy in CAD patients at our hospital. All patients received rituximab-containing therapy for at least 1 month. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-69465-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391738PMC

Current and Future Perspectives on ADAMTS13 and Thrombotic Thrombocytopenic Purpura.

Hamostaseologie 2020 Aug 29;40(3):322-336. Epub 2020 Jul 29.

Service d'Hématologie Biologique, Hôpital Lariboisière, and EA3518, Institut de Recherche Saint-Louis, Hôpital Saint Louis, AP-HP.Nord, Université de Paris, Paris, France.

Thrombotic thrombocytopenic purpura (TTP) is a rare, relapsing, and life-threatening disorder with an annual incidence of 10 cases per million people. TTP is a thrombotic microangiopathy characterized by severe thrombocytopenia, microangiopathic hemolytic anemia, and organ ischemia. The disease is caused by a severe deficiency of the enzyme ADAMTS13 (), which can either be acquired, mainly by autoantibodies targeting ADAMTS13, or congenital due to mutations in the gene. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-1171-0473DOI Listing

Thrombotic microangiopathy due to Bothrops erythromelas: a case report in Northeast Brazil.

Rev Inst Med Trop Sao Paulo 2020 24;62:e53. Epub 2020 Jul 24.

Departamento de Medicina Interna, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.

Bothrops erythromelas are serpents that belong to the Viperidae family, which are the main species responsible for human snakebites in Ceara State, Northeast Brazil. Thrombotic microangiopathy (TMA) is an uncommon group of disorders characterized by microangiopathic hemolytic anemia (MAHA), thrombocytopenia and acute kidney injury (AKI), and occurrence after snakebites have been rarely reported. In this report, we described the case of a 57 year-old-man without comorbidities who was bitten by a Bothrops erythromelas on his right ankle. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/s1678-9946202062053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384591PMC

Treatment-associated hemolysis in Kawasaki disease: association with blood-group antibody titers in IVIG products.

Blood Adv 2020 Jul;4(14):3416-3426

Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Amsterdam University Medical Center (UMC), University of Amsterdam, Amsterdam, The Netherlands.

Hemolytic anemia resulting from IV Immunoglobulin (IVIG) treatment can be a serious complication, especially for those with underlying conditions with a high level of inflammation and after administration of high IVIG dosages, such as Kawasaki disease (KD), a multisystem vasculitis affecting young children. This hemolysis is caused by antibodies against blood groups A and B, but the precise mechanism for hemolysis is not known. We performed a single center, partly retrospective, partly prospective study of a cohort of 581 patients who received IVIG for treatment of KD from 2006 to 2013. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/bloodadvances.2020002253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391134PMC

Review of clinical aspects, epidemiology and diagnosis of haemotropic Mycoplasma ovis in small ruminants: current status and future perspectives in tropics focusing on Malaysia.

Trop Anim Health Prod 2020 Jul 26. Epub 2020 Jul 26.

Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia (UPM), 43400, Serdang, Selangor, Malaysia.

Mycoplasma ovis (formerly Eperythrozoon ovis) is an epierythrocytic parasitic bacterium of small ruminants known as haemotropic mycoplasma, which is transmitted mechanically by biting flies and contaminated instruments. Acute mycoplasmosis causes severe haemolytic anaemia and mortality in young animals. At the same time, chronic disease may produce mild anaemia and varying degrees of morbidity depending on several factors, including age, reproductive status, the plane of nutrition, immunological status and the presence of concurrent infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11250-020-02357-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382646PMC

First report of expansion of CD4/CD28 null T-helper lymphocytes in adult patients with idiopathic autoimmune hemolytic anemia.

Hematol Transfus Cell Ther 2020 Jul 16. Epub 2020 Jul 16.

Internal Medicine department, Clinical Hematology and BMT unit (2), faculty of medicine, Ain Shams University, Cairo; Egypt. Electronic address:

CD28 null T helper (T) cells are rare in healthy individuals, but they are increased in various inflammatory and immune-mediated diseases. In this study, we determined the size of the CD4/CD28 null T lymphocyte compartment in the peripheral blood of 40 autoimmune hemolytic anemia (AIHA) patients (idiopathic and secondary) and 20 healthy control subjects, using tri-color flow cytometry. The frequency and absolute count of CD4/CD28 null T helper (T) cells was significantly higher in idiopathic AIHA patients, compared to healthy controls (p = 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.htct.2020.04.010DOI Listing

Molecular heterogeneity of pyruvate kinase deficiency.

Haematologica 2020 Jul 23. Epub 2020 Jul 23.

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano.

Red cell pyruvate kinase deficiency is the most common glycolytic defect associated with congenital non-spherocytic hemolytic anemia. The disease, transmitted as an autosomal recessive trait, is caused by mutations in the PKLR gene and is characterized by molecular and clinical heterogeneity; anemia ranges from mild or fully compensated hemolysis to life-threatening forms necessitating neonatal exchange transfusions and/or subsequent regular transfusion support; complications include gallstones, pulmonary hypertension, extramedullary hematopoiesis and iron overload. Since identification of the first pathogenic variants responsible for PK deficiency in 1991, more than 300 different variants have been reported, and the study of molecular mechanisms and the existence of genotype-phenotype correlations have been investigated in-depth. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2019.241141DOI Listing

A novel PIEZO1 mutation in a patient with dehydrated hereditary stomatocytosis: a case report and a brief review of literature.

Ital J Pediatr 2020 Jul 23;46(1):102. Epub 2020 Jul 23.

Department of Pediatrics, "Lalla Seràgnoli," Hematology-Oncology Unit, Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 11, 40137, Bologna, Italy.

Background: Dehydrated hereditary stomatocytosis (DHS) or hereditary xerocytosis is a rare, autosomal dominant hemolytic anemia characterized by macrocytosis, presence of stomatocytes and dehydration of red blood cells (RBCs). The dehydration is caused by a defect in cellular cation content. The most frequent expression of the pathology is hemolytic well-compensated anemia with high reticulocyte count, a tendency to macrocytosis, increased mean corpuscular hemoglobin concentration (MCHC) and mild jaundice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13052-020-00864-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379360PMC

Cluster analysis for the identification of clinical phenotypes among antiphospholipid antibody-positive patients from the APS ACTION Registry.

Lupus 2020 Jul 23:961203320940776. Epub 2020 Jul 23.

Barbara Volcker Centre for Women and Rheumatic Disease, Hospital for Special Surgery, Weill Cornell Medicine, New York, USA.

Objective: This study aimed to use cluster analysis (CA) to identify different clinical phenotypes among antiphospholipid antibodies (aPL)-positive patients.

Methods: The Alliance for Clinical Trials and International Networking (APS ACTION) Registry includes persistently positive aPL of any isotype based on the Sydney antiphospholipid syndrome (APS) classification criteria. We performed CA on the baseline characteristics collected retrospectively at the time of the registry entry of the first 500 patients included in the registry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203320940776DOI Listing

Coagulation Status and Venous Thromboembolism Risk in African Americans: A Potential Risk Factor in COVID-19.

Clin Appl Thromb Hemost 2020 Jan-Dec;26:1076029620943671

Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Severe acute respiratory syndrome coronavirus 2 infection (COVID-19) is known to induce severe inflammation and activation of the coagulation system, resulting in a prothrombotic state. Although inflammatory conditions and organ-specific diseases have been shown to be strong determinants of morbidity and mortality in patients with COVID-19, it is unclear whether preexisting differences in coagulation impact the severity of COVID-19. African Americans have higher rates of COVID-19 infection and disease-related morbidity and mortality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1076029620943671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383642PMC

Glucose-6-Phosphate Dehydrogenase Deficiency.

Blood 2020 Jul 23. Epub 2020 Jul 23.

Istituto per Studio, la Prevenzione e la Rete Oncologica (ISPRO), Firenze, Italy.

Glucose 6-phosphate dehydrogenase (G6PD) deficiency is one of the commonest human enzymopathies: it is due to inherited mutations of the X-linked gene G6PD. G6PD deficiency makes red cells highly vulnerable to oxidative damage, and therefore susceptible to hemolysis. Over 200 G6PD mutations are known: about one-half are polymorphic and therefore common in various populations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood.2019000944DOI Listing

Red Cell Membrane Disorders: Structure meets Function.

Blood 2020 Jul 23. Epub 2020 Jul 23.

Cincinnati Children's Hospital Medical Center and University of Cinicinnati, Cincinnati, Ohio, United States.

The mature red blood cell (RBC) is lacking a nucleus and organelles characteristic of most cells, but it is elegantly structured to perform the essential function of delivering oxygen and removing carbon dioxide from all other cells while enduring the shear stress imposed by navigating small vessels and sinusoids. Over the past several decades the efforts of biochemists, cell and molecular biologists, and hematologists have provided an appreciation of the complexity of RBC membrane structure, while studies of the RBC membrane disorders have offered valuable insights into structure-function relationships. Within the last decade advances in genetic testing and its increased availability have made it possible to substantially build upon this foundational knowledge. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood.2019000946DOI Listing

Management of Pyruvate Kinase Deficiency in Children and Adults.

Blood 2020 Jul 23. Epub 2020 Jul 23.

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Pyruvate Kinase Deficiency (PKD) is an autosomal recessive enzyme defect of the glycolytic pathway that causes congenital, non-spherocytic hemolytic anemia.  The diagnosis and management of patients with PKD can be challenging due to difficulties in the diagnostic evaluation and the heterogeneity of clinical manifestations, ranging from fetal hydrops and symptomatic anemia requiring lifelong transfusions to fully compensated hemolysis.  Current treatment approaches are supportive and include transfusions, splenectomy, and chelation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood.2019000945DOI Listing

Management of Non-criteria Manifestations in Antiphospholipid Syndrome.

Curr Rheumatol Rep 2020 Jul 22;22(9):51. Epub 2020 Jul 22.

First Department of Propaedeutic Internal Medicine, Joint Rheumatology program, Medical School, 'Laiko' Hospital, National and Kapodistrian University of Athens, 17 Agiou Thoma Street., 11527, Athens, Greece.

Purpose Of The Review: To review the available evidence on the management of a variety of non-criteria manifestations in antiphospholipid syndrome (APS), including valvular disease, alveolar hemorrhage, thrombocytopenia, hemolytic anemia, APS nephropathy, skin ulcers, livedo reticularis, cognitive dysfunction, and epilepsy.

Recent Findings: Current treatment relies on low-level evidence and mainly on expert consensus due to the rarity and the heterogeneity of non-criteria APS manifestations and the diversity in management approaches. Conventional anticoagulation and/or antiplatelet APS treatment do not adequately control most of non-criteria manifestations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11926-020-00935-2DOI Listing

Thrombotic Thrombocytopenic Purpura: Revisiting a Miss and an Inevitable Consequence.

Cureus 2020 Jul 19;12(7):e9283. Epub 2020 Jul 19.

Internal Medicine, Saint Peter's University Hospital/Rutgers University, New Brunswick, USA.

Thrombotic thrombocytopenic purpura (TTP) is typically characterized by the symptomatic pentad of fever, thrombocytopenia, microangiopathic hemolytic anemia, neurologic abnormalities, and renal failure. Atypical TTP is the diagnosis used to describe the subset of patients with TTP who present with symptoms that deviate from the classic pentad. We report a case an 86-year-old woman who presented to the emergency department complaining of chest pain for one day. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.9283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372183PMC

Drug-Induced Immune Hemolytic Anemia due to Amoxicillin-Clavulanate: A Case Report and Review.

Cureus 2020 Jun 17;12(6):e8666. Epub 2020 Jun 17.

Internal Medicine, University of Pittsburgh Medical Center (UPMC) Pinnacle, Harrisburg, USA.

Drug-induced immune hemolytic anemia (DIIHA) is a rare cause of anemia. It is often difficult to distinguish from other causes of hemolytic anemia, thereby delaying diagnosis and treatment. Antibiotics, including penicillins and cephalosporins, are the drugs most often implicated in the development of DIIHA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.8666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370667PMC

Ceftriaxone-Induced Immune Hemolytic Anemia.

Cureus 2020 Jun 17;12(6):e8660. Epub 2020 Jun 17.

Internal Medicine, Ascension Health, Milwaukee, USA.

Ceftriaxone is a commonly used antibiotic in hospitals for the treatment of pneumonia, urinary tract infection, bacteremia, meningitis, skin, and soft tissue infection. It can be associated with common allergic reactions like skin rash, itching, and, rarely, angioedema. Ceftriaxone-induced immune hemolytic anemia (IHA) is a rare and potentially fatal complication if not identified and managed in time. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.8660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370697PMC

A Case of COVID-19 in a Patient with Asymptomatic Hemoglobin D Thalassemia and Glucose-6-Phosphate Dehydrogenase Deficiency.

Am J Case Rep 2020 Jul 22;21:e925788. Epub 2020 Jul 22.

Department of Infectious Diseases, Communicable Disease Center, Hamad Medical Corporation, Doha, Qatar.

BACKGROUND Beta-hemoglobinopathies and glucose-6-phosphate dehydrogenase (G6PD) deficiency are genetic disorders that cause hemolytic anemia when exposed to oxidative stress. Their co-existence is, however, not proven to enhance the severity of anemia. CASE REPORT We report the case of a young man with no known co-morbidities, who came with fever and cough and was diagnosed with COVID-19 pneumonia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/AJCR.925788DOI Listing

Dabigatran-induced chronic progressive immune hemolytic anemia: A case report.

J Stroke Cerebrovasc Dis 2020 Aug 5;29(8):104924. Epub 2020 Jun 5.

Department of Radiotherapy, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Xinglong Road 29, Tianning District, Changzhou 213000, China. Electronic address:

Dabigatran is an orally active direct thrombin inhibitor, initially approved by FDA for the prophylaxis of stroke and systemic embolism in the setting of non-valvular atrial fibrillation (NVAF). Major bleeding is its most common adverse event which is of great concern. However, other types of adverse events such as esophagitis, esophageal ulcer, exanthem and pustular eruptions were reported increasingly in recent years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2020.104924DOI Listing

A Case of Systolic Anterior Motion After Mitral Valve Repair Causing Hemolytic Anemia: Mechanism and Treatment.

Can J Cardiol 2020 Jul 17. Epub 2020 Jul 17.

Division of Cardiothoracic Surgery, UC Davis Medical Center, Sacramento, California, USA.

Hemolytic anemia following mitral valve repair and ring annuloplasty is uncommon compared with mitral valve replacement. A 67-year-old woman, who had undergone mitral valve repair (MVR) with a Duran band, developed hemolytic anemia. Most cases of severe hemolysis after mitral valve repair have undergone re-operation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cjca.2020.07.008DOI Listing

Rhesus-minus phenotype as a predictor of sexual desire and behavior, wellbeing, mental health, and fecundity.

PLoS One 2020 20;15(7):e0236134. Epub 2020 Jul 20.

Department of Philosophy and History of Science, Faculty of Science, Charles University, Prague, Czech Republic.

Background: Since its discovery in the 1930s, the effects of Rh phenotype on human health and wellbeing, with the exception of the effects of Rh-negativity of a mother on the risk of hemolytic anemia of Rh-positive children, has only rarely been studied. In the last few years, however, several studies have shown that Rh-negative subjects have worse health and performance in certain tests than their Rh-positive peers. Nothing is known about the effect of Rh phenotype on the quality of life of subjects as measured by a standard instrument. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0236134PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371180PMC

Naphthalene Toxicity in a Three-Year-Old Child Complicated by Severe Hemolytic Anemia and Mild Methemoglobinemia: A Case Report.

J Emerg Med 2020 Jul 15. Epub 2020 Jul 15.

King Fahad Medical City, Riyadh, Saudi Arabia.

Background: Exposure to naphthalene, which is widely used in mothballs, does not usually produce adverse effects. However, naphthalene can be toxic, especially in individuals with underlying conditions such as glucose-6-phosphate-dehydrogenase (G6PD) deficiency.

Case Report: A 3-year-old boy was brought to our Emergency Department after accidentally ingesting naphthalene mothballs 3 days prior to presentation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jemermed.2020.06.009DOI Listing

IVIg and hemolytic anemia risk: dump the anti-A/B already!

Transfusion 2020 Jul;60(7):1337-1339

Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/trf.15939DOI Listing