82,907 results match your criteria Hemolytic Anemia


Murine bone marrow mesenchymal stromal cells have reduced hematopoietic maintenance ability in sickle cell disease.

Blood 2021 Jul 30. Epub 2021 Jul 30.

New York Blood Center, New York, New York, United States.

Sickle Cell Disease (SCD) is characterized by hemolytic anemia, which can trigger oxidative stress, inflammation, and tissue injury that contributes to disease complications. Bone marrow mesenchymal stromal cells (MSCs) tightly regulate hematopoietic stem cell (HSC) homeostasis in health and disease but their functionality in SCD remains unclear. We identified for the first time murine SCD MSCs to have altered gene signatures, reduced stem cell properties, and increased oxidative stress, due in part to hemolysis. Read More

View Article and Full-Text PDF

Protective effect of Beta vulgaris roots supplementation on anemic phenylhydrazine-intoxicated rats.

Environ Sci Pollut Res Int 2021 Jul 28. Epub 2021 Jul 28.

Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt.

Anemia is a public health problem that affects many people worldwide. Beetroot (Beta vulgaris) is a plant supposed to have many healthy features. The present study was done to evaluate the anti-anemic effect of beetroot supplement on anemia induced by phenylhydrazine in albino rats. Read More

View Article and Full-Text PDF

Therapeutic lessons from transfusion in pregnancy-effect on hematological parameters and coagulation profile.

Am J Blood Res 2021 15;11(3):303-316. Epub 2021 Jun 15.

ICMR-National Institute of Pathology, Safdarjung Hospital Campus Ansari Nagar, New Delhi, India.

Introduction: Transfusion is commonly done in clinical indications and complications arising due to Anemia, shock, blood loss, thrombocytopenia due to any cause, ineffective erythropoiesis. Pregnancy is a physiological condition characterized by Anemia, fluid overload, hypercoagulable state, and antifibrinolytic condition, which can cause various reactions that could be anticipated during a blood transfusion. With an aim to understand the effects of transfusions on hematological parameters in pregnancy. Read More

View Article and Full-Text PDF

Hyperhomocysteinemia-related lung disease and hemolytic anemia with bone marrow features masquerading as myelodysplasia.

Am J Blood Res 2021 15;11(3):266-270. Epub 2021 Jun 15.

Department of Laboratory Medicine, Uji-Tokushukai Medical Center Uji, Kyoto, Japan.

Hyperhomocysteinemia is linked to TMA-related clinical symptoms such as apparent thromboembolism, microangiopathic hemolytic anemia (MAHA), and various types of end-organ damage due to microvascular thrombi; this is because high plasma levels of homocysteine impair the vascular endothelium. However, the association between hyperhomocysteinemia and pulmonary involvement is unclear. Here, we describe a 63-year-old male who was hospitalized with respiratory failure and MAHA with MDS-like features in the bone marrow. Read More

View Article and Full-Text PDF

Rare hereditary nonspherocytic hemolytic anemia caused by a novel homozygous mutation, c.301C > A, (Q101K), in the AK1 gene in an Indian family.

BMC Med Genomics 2021 Jul 28;14(1):191. Epub 2021 Jul 28.

Department of Haematogenetics, ICMR-National Institute of Immunohaematology, Indian Council of Medical Research, 13th Floor, New Multistorey Building, KEM Hospital Campus, Parel, Mumbai, 400012, India.

Background: Adenylate kinase (AK) deficiency is a rare red cell enzymopathy associated with moderate to severe congenital nonspherocytic hemolytic anemia, along with mental and psychomotor retardation (in exceptional cases). Only ten mutations have been detected in the AK1 gene to date. In this study, we aimed to diagnose the unexplained issue of haemolytic anaemia and offer antenatal screening to the family. Read More

View Article and Full-Text PDF

Acute ST-Segment Elevation Myocardial Infarction as Initial Presentation of Atypical Hemolytic-Uremic Syndrome.

JACC Case Rep 2021 Apr 3;3(4):561-565. Epub 2021 Mar 3.

Department of Pulmonary and Critical Care Medicine, University of Southern California, Los Angeles, California, USA.

A young woman presented with an acute ST-segment elevation myocardial infarction. Her clinical course was complicated by cardiogenic shock and acute renal failure. Work-up revealed thrombocytopenia and hemolytic anemia. Read More

View Article and Full-Text PDF

Red Blood Cell Fragmentation Syndrome After Placement of MitraClip.

JACC Case Rep 2020 Jun 17;2(7):1084-1088. Epub 2020 Jun 17.

Division of Cardiology, University of Colorado School of Medicine, Aurora, Colorado.

An 87-year-old woman with a history of trastuzumab-induced left ventricular dysfunction underwent the MitraClip (Abbott Vascular, Santa Clara, California) procedure for myxomatous mitral regurgitation. She presented a month later with severe intravascular hemolytic anemia, attributed to the MitraClip. She underwent surgical mitral valve replacement and had resolution of hemolysis. Read More

View Article and Full-Text PDF

Transcatheter Aortic Valve Replacement for Aortic Stenosis With Prosthetic Mitral Paravalvular Leak and Hemolytic Anemia.

JACC Case Rep 2020 Nov 18;2(14):2146-2150. Epub 2020 Nov 18.

Department of Cardiac Surgery, National Cerebral and Cardiovascular Center, Osaka, Japan.

This report describes a successful transcatheter aortic valve replacement in an older patient with severe aortic stenosis, mitral paravalvular leak, and associated hemolytic anemia. Transcatheter aortic valve replacement is worth considering as a first-line procedure in this high-risk patient because of its beneficial impact on reducing shear forces at the mitral valve. (). Read More

View Article and Full-Text PDF
November 2020

Transcatheter Repair of Anterior Mitral Leaflet Perforation: Deploy, Retrieve, Redeploy.

JACC Case Rep 2019 Dec 18;1(5):689-693. Epub 2019 Dec 18.

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa.

We describe a case of anterior mitral leaflet perforation successfully treated with the Amplatzer Cribriform device, with resultant hemolytic anemia. The device was retrieved, and perforation occluded with the GORE CARDIOFORM device with resolution of hemolysis. (). Read More

View Article and Full-Text PDF
December 2019

Isolated B-cell lymphopenia and autoimmune hemolytic anemia as a curious combination of findings at the time of advanced Hodgkin lymphoma diagnosis: a pediatric case report.

AME Case Rep 2021 25;5:26. Epub 2021 Jul 25.

Division of Allergy and Immunology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.

Lymphopenia is associated with poor outcome in Hodgkin lymphoma (HL), but the impact of specific cytopenias is unexplored. We report a case of isolated B-cell lymphopenia with HL, EBV infection, and autoimmune hemolytic anemia (AIHA). Our patient is a 19-year-old male without any significant past medical history who presented with two weeks of epigastric abdominal pain, subjective fevers, night sweats, fatigue and a five-pound weight loss. Read More

View Article and Full-Text PDF

Cold agglutinin disease and COVID-19 requiring therapeutic plasma exchange.

BMJ Case Rep 2021 Jul 26;14(7). Epub 2021 Jul 26.

University of Toronto Faculty of Medicine, Toronto, Ontario, Canada

A 70-year-old man with known cold autoimmune haemolytic anaemia was referred to the emergency department with increased shortness of breath on exertion. He had been confirmed positive for non-variant COVID-19 infection 1 week earlier based on nasopharyngeal swab PCR assay. CT thorax demonstrated diffuse patchy bilateral ground glass opacities, consistent with COVID-19 pneumonia. Read More

View Article and Full-Text PDF

Subglottic concretion masquerading as foreign body in a child with β thalassemia major: an airway nightmare!

BMJ Case Rep 2021 Jul 26;14(7). Epub 2021 Jul 26.

Pathology, Army Hospital Research and Referral, New Delhi, India.

Subglottic concretion is a rare and perilous condition usually presenting with existing or impending airway obstruction. Due to long-standing nature of the condition, slow progression of symptoms and rarity of occurrence, the condition is either missed or misdiagnosed. Its resemblance in presentation and symptoms to that of foreign body (FB) bronchus can lead to a diagnostic misadventure. Read More

View Article and Full-Text PDF

Presumed complement-mediated, checkpoint inhibitor-induced, thrombotic microangiopathy in a patient with metastatic melanoma.

BMJ Case Rep 2021 Jul 26;14(7). Epub 2021 Jul 26.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

Immune checkpoint inhibitors (ICIs) are associated with a variety of immune-related adverse events (irAEs), but haematological irAEs are rare. We report a case of presumed complement-mediated thrombotic microangiopathy (CM-TMA) in a 78-year-old man with metastatic melanoma following treatment with ICIs. Following two doses of combination nivolumab and ipilimumab therapy, he developed microangiopathic haemolytic anaemia, thrombocytopenia and increased creatinine. Read More

View Article and Full-Text PDF

A Sri Lankan girl with a new genetic variant in the PKLR gene causing pyruvate kinase deficiency: a case report.

J Med Case Rep 2021 Jul 27;15(1):374. Epub 2021 Jul 27.

Department of Molecular Pathology, Viapath at King's College Hospital, King's College Hospital, London, SE5 9RS, UK.

Background: Erythrocyte pyruvate kinase is expressed under the control of the PKLR gene located on chromosome 1q21. Pyruvate kinase catalyzes the final steps of the glycolytic pathway and creates 50% of the red cell total adenosine triphosphate. Pyruvate kinase deficiency is the commonest glycolytic defect causing congenital non-spherocytic hemolytic anemia inherited in an autosomal recessive trait in which homozygotes and compound heterozygotes are common. Read More

View Article and Full-Text PDF

Hb Calgary (: c.194G>T): A Highly Unstable Hemoglobin Variant with a β-Thalassemia Major Phenotype.

Hemoglobin 2021 Jul 26:1-5. Epub 2021 Jul 26.

National Institute of Health Research (NIHR), Bristol Biomedical Research Centre (BRC), Oxford, UK.

We describe two unrelated patients, both heterozygous for an unstable hemoglobin (Hb) variant named Hb Calgary (: c.194G>T) that causes severe hemolytic anemia and dyserythorpoietic, resulting in transfusion dependence and iron overload. The molecular pathogenesis is a missense variation on the β-globin gene, presumed to lead to an unstable Hb. Read More

View Article and Full-Text PDF

Cytomegalovirus Infection Presenting as Severe Sepsis, Hepatitis, and Autoimmune Hemolytic Anemia in an Immunocompetent Child in Pediatric Intensive Care Unit.

Pediatr Infect Dis J 2021 Jul 22. Epub 2021 Jul 22.

Department of Pediatrics, All India Institute of Medical sciences Nagpur, Maharashtra, India Pediatric Intensivist, Zydus Hospital and Research Centre Ahmedabad, Gujarat, India.

View Article and Full-Text PDF

[Pseudo-thrombotic microangiopathy due to vitamin B12 deficiency in an infant].

Arch Argent Pediatr 2021 Aug;119(4):e326-e329

Unidad 6 de Clínica Pediátrica, Hospital de Niños Ricardo Gutiérrez, Ciudad Autónoma de Buenos Aires, Argentina.

Pseudo-thrombotic microangiopathy, or Moschcowitz syndrome, is a rare manifestation of vitamin B12 deficiency. It is characterized by microangiopathic hemolytic anemia, reticulocytes, and hematimetric indices that can be normal or that might present a mild megaloblastosis, and which are associated with neurological manifestations. Vitamin B12 can be found in animal-based protein foods. Read More

View Article and Full-Text PDF

Diagnostic sensitivity of extended renal and hematologic criteria to define hemolytic uremic syndrome.

Arch Argent Pediatr 2021 Aug;119(4):238-244

Unidad de Nefrología, Hospital General de Niños "Dr. Pedro de Elizalde", Ciudad Autónoma de Buenos Aires, Argentina.

Introduction: The usual definition of Shiga toxin-producing Escherichia coli hemolytic uremic syndrome (STEC-HUS) is based on the presence of anemia, thrombocytopenia, and elevated serum creatinine levels, with or without proteinuria and/or hematuria. The strict definition only considers elevated serum creatinine levels as a renal criterion. The extended definition maintains flexible renal criteria, although it replaces anemia with hemolysis and considers a sharp drop in platelet count as an indicator of platelet consumption. Read More

View Article and Full-Text PDF

Healthcare resource utilization among patients with cold agglutinin disease in Denmark.

Curr Med Res Opin 2021 Jul 24. Epub 2021 Jul 24.

Bioverativ, a Sanofi company, Waltham, MA, USA.

Objectives: Cold agglutinin disease (CAD) is a rare form of autoimmune hemolytic anemia that may manifest in complement-mediated chronic hemolytic anemia, profound fatigue, and transient agglutination-mediated circulatory symptoms. This study compared the healthcare resource utilization (HRU) of patients with CAD with a matched non-CAD comparison cohort using national Danish health registry data.

Methods: All cases of CAD were identified from January 1, 1999, to June 30, 2016, in the Danish National Patient Registry using International Classification of Diseases, Tenth Revision, discharge diagnosis codes. Read More

View Article and Full-Text PDF

Severe hyperbilirubinemia in a neonate with hereditary spherocytosis due to a ankyrin mutation: A case report.

World J Clin Cases 2021 Jul;9(19):5245-5251

Department of Neonatology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200062, China.

Background: Hereditary spherocytosis (HS) is a common type of hemolytic anemia caused by a red cell membrane disorder. HS type 1 (HS1) is mostly caused by mutations in ankyrin (). Newborns with HS1 usually only exhibit anemia and mild jaundice. Read More

View Article and Full-Text PDF

Case Report: Hodgkin Lymphoma and Refractory Systemic Lupus Erythematosus Unveil Activated Phosphoinositide 3-Kinase-δ Syndrome 2 in an Adult Patient.

Front Pediatr 2021 8;9:702546. Epub 2021 Jul 8.

Pediatric Unit, Istituti di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliero-Universitaria di Bologna, University of Bologna, Bologna, Italy.

Activated phosphoinositide 3-kinase-δ syndrome 2 (APDS2) is a rare primary immune regulatory disorder caused by heterozygous gain of function mutation in the gene encoding PI3Kδ regulatory p85α subunit and resulting in PI3Kδ hyperactivation. Clinical features range from recurrent infections to manifestations of immune dysregulation like autoimmunity, inflammation, systemic lymphoproliferation, and increased risk of cancer. We describe a new dominant mutation causing APDS2 presenting with lymphoma and systemic refractory autoimmunity. Read More

View Article and Full-Text PDF

[Novel PKLR gene mutation related erythropyruvate kinase deficiency: a case report].

Authors:
M Hui M Chen

Zhonghua Nei Ke Za Zhi 2021 Aug;60(8):767-768

Department of Hematology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

View Article and Full-Text PDF

Transplant-associated thrombotic microangiopathy: elucidating prevention strategies and identifying high-risk patients.

Expert Rev Hematol 2021 Jul 23. Epub 2021 Jul 23.

Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Introduction: : Hematopoietic stem cell transplantation-associated thrombotic microangiopathy (TA-TMA) is a severe complication of transplant. TA-TMA is a multifactorial disease where generalized endothelial dysfunction leads to microangiopathic hemolytic anemia, intravascular platelet activation, and formation of microthrombi leading to end-organ injury. It is essential to identify patients at risk for this complication and to implement early interventions to improve TA-TMA associated transplant outcomes. Read More

View Article and Full-Text PDF

Common Variable Immunodeficiency and Autoimmune Diseases: A Retrospective Study of 95 Adult Patients in a Single Tertiary Care Center.

Front Immunol 2021 5;12:652487. Epub 2021 Jul 5.

Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.

Common variable immunodeficiency (CVID) is the most common clinically significant primary immunodeficiency in adulthood, which presents a broad spectrum of clinical manifestations, often including non-infectious complications in addition to heightened susceptibility to infections. These protean manifestations may significantly complicate the differential diagnosis resulting in diagnostic delay and under-treatment with increased mortality and morbidity. Autoimmunity occurs in up to 30% of CVID patients, and it is an emerging cause of morbidity and mortality in this type of patients. Read More

View Article and Full-Text PDF

The impact of body mass index on left ventricular mass index, right ventricular function, and cardiac dimension of children with sickle cell anemia in Enugu City.

Niger J Clin Pract 2021 Jul;24(7):1044-1051

Consultant Community Physician and Lecturer, Enugu State University Teaching Hospital, Enugu State, Nigeria.

Background: Body mass index is a major determinant of cardiac annular valvar dimension and left ventricular mass index in children with sickle cell anemia.

Objectives: The study is aimed at ascertaining the impact of Body Mass Index on Left ventricular mass index, right ventricular function and cardiac dimension of children with sickle cell anemia.

Methods: A case control study in which echocardiographic measurement of cardiac function and structures were ascertained among children with sickle cell anemia compared with hemoglobin AA genotype. Read More

View Article and Full-Text PDF

Adalimumab-Induced Rhupus Syndrome in a Female Patient Affected with Anti-Citrullinated Protein Antibody (ACPA)-Positive Rheumatoid Arthritis (RA): A Case Report and Review of Literature.

Clin Pract 2021 Jul 1;11(3):404-409. Epub 2021 Jul 1.

Primary Care Department, Casa Della Salute "Chiaravalle Centrale", Fragility Outpatient Clinic, Azienda Sanitaria Provinciale di Ca-tanzaro, Chiaravalle, 88064 Catanzaro, Italy.

We report a 38-year-old female patient affected with anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA) who developed mild hemolytic anemia (Hb = 10.5 vs. >12 gr/dL), indolent oral ulceration, ANA (1:1280, homogeneous pattern), and anti-dsDNA antibody positivity following 8 months of therapy with an adalimumab biosimilar (GP2017). Read More

View Article and Full-Text PDF

The wide spectrum of β-thalassaemia intermedia-induced pulmonary hypertension: two case reports on the possible role of specific pulmonary arterial hypertension therapy.

Pulm Circ 2021 Jul-Sep;11(3):20458940211030490. Epub 2021 Jul 6.

2nd Department of Critical Care and Pulmonary Hypertension Clinic, National & Kapodistrian University of Athens, Attikon Hospital, Athens, Greece.

Pulmonary hypertension (PH) development remains a significant cardiovascular complication of haemoglobinopathies, severely affecting the morbidity and mortality of such patients. According to the 5th World Symposium on PH, PH related with chronic haemolytic anaemias is classified in group 5, mainly due to the multifactorial pathophysiology of PH in this patient population. There are no clear guidelines regarding the management of PH in patients with haemoglobinopathies; the use of specific pulmonary arterial hypertension (PAH) therapy in patients with β-thalassaemia and PH is based on data derived from other forms of PH, expert opinion and small series or case reports. Read More

View Article and Full-Text PDF

Diagnosis of Evans syndrome.

Pan Afr Med J 2021 29;38:314. Epub 2021 Mar 29.

Cardiology Department, 417 NIMTS Hospital, Athens, Greece.

This manuscript concerns the case of a patient hospitalized and diagnosed with Evans syndrome. She was hospitalized with signs of thrombocytopenia induced purpura, petechiae, ecchymosis and anemia. She was successfully treated with corticoids and blood transfusions. Read More

View Article and Full-Text PDF

In vitro Immunomodulatory Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells on Peripheral Blood Cells from Warm Autoimmune Hemolytic Anemia Patients.

Acta Haematol 2021 Jul 20:1-9. Epub 2021 Jul 20.

Department of Blood Transfusion, First Medical Center of Chinese PLA General Hospital, Beijing, China.

Introduction: Autoimmune hemolytic anemia is a potentially lethal disease characterized by autoimmune hemolysis. Although human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have been reported as a promising therapy, there is limited evidence regarding warm autoimmune hemolytic anemia (wAIHA) patients. This study aimed to investigate the potential therapeutic effects of hUC-MSCs via immune regulation in wAIHA patients. Read More

View Article and Full-Text PDF