86,098 results match your criteria Hemolytic Anemia

Practical therapy for primary autoimmune hemolytic anemia in adults.

Clin Exp Med 2022 Aug 18. Epub 2022 Aug 18.

UO di Medicina, Ospedale di Ostuni, via Villafranca SN, Ostuni, BR, Italy.

Background And Aim: Autoimmune hemolytic anemias (AIHA) constitute a rare and heterogeneous group of diseases whose therapy differs according to the type of antibody involved in the genesis of the disease and the existence or not of an identified cause. With the aim of providing a practical guide for the therapy of AIHA, we summarize the emergency therapy and general measures habitually used in all forms of AIHA, as well as the specific treatment of the most frequent primary forms of AIHA: primary warm AIHA and AIHA from cold agglutinin disease (AIHA from CAD). We discuss the dependence of the treatment of the secondary forms on their underlying causes and the changes in the treatment of the primary forms in recent years. Read More

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Systemic Lupus Erythematosus Presenting With Thrombotic Thrombocytopenic Purpura at Onset: A Case Report.

Front Pediatr 2022 1;10:931669. Epub 2022 Aug 1.

Department of Pediatrics, Gunma University Graduate School of Medicine, Maebashi, Japan.

Background: Thrombotic microangiopathy (TMA) is a syndrome associated with hemolytic anemia, thrombocytopenia, and various organ disorders. Thrombotic thrombocytopenic purpura (TTP) is a disease that develops when a disintegrin-like and metalloproteinase with thrombospondin type l motif 13 (ADAMTS13) activity decreases to < 10% of that in normal plasma, causing platelet thrombosis in microvessels throughout the body. Currently, ADAMTS13-deficient TMA is diagnosed as TTP. Read More

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MARTX toxin of Vibrio vulnificus induces RBC phosphatidylserine exposure that can contribute to thrombosis.

Nat Commun 2022 Aug 17;13(1):4846. Epub 2022 Aug 17.

National Research Laboratory of Molecular Microbiology and Toxicology, Department of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Republic of Korea.

V. vulnificus-infected patients suffer from hemolytic anemia and circulatory lesions, often accompanied by venous thrombosis. However, the pathophysiological mechanism of venous thrombosis associated with V. Read More

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Longitudinal proteomics study of serum changes after allogeneic HSCT reveals potential markers of metabolic complications related to aGvHD.

Sci Rep 2022 Aug 17;12(1):14002. Epub 2022 Aug 17.

School of Life Science and Technology, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo, 152-8550, Japan.

Even though hematopoietic stem cell transplantation (HSCT) allows successful treatment for many malignant and non-malignant disorders, its curative potential remains limited by severe side effects, including infections and other transplant-related complications such as graft-versus-host disease (GvHD). This study examined changes in serum proteome via high-performance two-dimensional gel electrophoresis (2-DE) during HSCT to search for diagnostic biomarkers for post-HSCT complications. Longitudinal proteomic analysis revealed proteins related to metabolic complications and hemolytic anemia. Read More

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Risk of hemolysis in Plasmodium vivax malaria patients receiving standard primaquine treatment in a population with high prevalence of G6PD deficiency.

Infection 2022 Aug 17. Epub 2022 Aug 17.

Department of Internal Medicine, Morsani College of Medicine, University of South Florida, 3720 Spectrum Boulevard, Suite 304, Tampa, FL, 33612, USA.

Background: Primaquine is essential for the radical cure of Plasmodium vivax malaria, but it poses a potential danger of severe hemolysis in G6PD-deficient (G6PDd) patients. This study aimed to determine whether primaquine is safe in a population with high G6PD prevalence but lacking G6PD diagnosis capacity.

Methods: In Myanmar, 152 vivax patients were gender- and age-matched at 1:3 for G6PDd versus G6PD-normal (G6PDn). Read More

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[Diagnostic clues in atypical hemolytic uremic syndrome: a case report].

An Sist Sanit Navar 2022 Aug 17;45(2). Epub 2022 Aug 17.

Servicio de Análisis Clínicos. Hospital Universitario de Navarra. Servicio Navarro de Salud-Osasunbidea. Pamplona. España..

Atypical hemolytic uremic syndrome (aHUS) is a clinical entity characterized by non-immune hemolytic anemia, thrombocytopenia and renal failure, in which lesions are mediated by a systemic thrombotic microangiopathy. It is a rare pathology whose origin is a complement system deregulation due to mutations in its genes that lead to uncontrolled activation of C5 and the formation of the membrane attack complex.- Its correct diagnosis allows us to prescribe the treatment based on Eculizumab, a C5 inhibitor. Read More

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Prognosis and Overall Survival of Thalassemia Patients using Semi-Parametric Mixture Cure-Rate Model: a 30-Year Retrospective Cohort Study.

Clin Lab 2022 Jul;68(7)

Background: Understanding the determinants of long-term overall survival (OS) of thalassemia patients (TPs) is the mainstay of care.

Methods: As a retrospective survey, we assessed the data of 769 TPs who had regular follow-up and blood transfusion for at least 30 years from 1990 - 2019. We utilized semi-parametric proportional hazards mixture cure-rate regression to discover the factors with a significant effect on short- and long-term OS separately. Read More

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study of the effect of high temperature on erythrocytes in sickle cell trait.

Maher M Aljohani

Niger J Clin Pract 2022 Aug;25(8):1318-1323

Department of Pathology, College of Medicine, Taibah University, Al-Madinah Al-Monawarah, Kingdom of Saudi Arabia.

Background: Although, sickle cell trait (SCT) was considered a benign condition with most patients being asymptomatic, however, there is an impressive increase in the number of sudden deaths in the military recruits and athletes, which has led to SCT as a rapidly emerging medical issue. Genetic factors have been extensively investigated in the etiopathogenesis of SCT but, environmental factors have not been studied in depth.

Aims: The main aim of this study was to investigate the effect of high temperature on the red blood cells (RBCs) in those with SCT and compare this to a control group lacking SCT. Read More

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Depression among patient with sickle cell disease: Prevalence and prediction.

Niger J Clin Pract 2022 Aug;25(8):1274-1278

Department of Neuroscience, College of Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.

Background: Depression is a widespread disorder with either an independent or interrelated relationship with chronic disease.

Aim: This study aims to assess depression prevalence and its predictors among patients with sickle cell disease (SCD).

Patients And Methods: This is a cross-sectional study conducted in Saudi Arabia where patients with SCD assessed for having depression through Patient Health Questionnaire (PHQ9). Read More

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Intravenous immunoglobulin in hemolytic disease of the newborn: A moving target in time.

Niger J Clin Pract 2022 Aug;25(8):1262-1268

Department of Neonatology, University of Health Sciences, Zeynep Kamil Maternity and Children's Disease Health Training and Research Center-Istanbul, Turkey.

Background: Alloimmune hemolytic disease of the newborn (AIHDN) results in hemolysis, anemia, hyperbilirubinemia with the potential for brain damage. Intravenous immunoglobulin (IVIG) has been investigated as an alternative low-risk procedure for the treatment of AIHDN in addition to traditional treatment methods such as phototherapy and exchange transfusion (ET).

Aim: To evaluate the effectiveness of IVIG therapy in decreasing ET needs based on risk factors and clinical outcomes. Read More

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Inpatient palliative care use by patients with sickle cell disease: a retrospective cross-sectional study.

BMJ Open 2022 Aug 16;12(8):e057361. Epub 2022 Aug 16.

UTHealth Consortium on Aging; Department of Management, Policy and Community Health, UTHealth School of Public Health, Houston, Texas, USA.

Objective: Sickle cell disease (SCD) is a highly morbid condition notable for recurrent hospitalisations due to vaso-occlusive crises and complications of end organ damage. Little is known about the use of inpatient palliative care services in adult patients with SCD. This study aims to evaluate inpatient palliative care use during SCD-related hospitalisations overall and during terminal hospitalisations. Read More

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Preoperative Transfusion and Surgical Outcomes for Children with Sickle Cell Disease.

J Am Coll Surg 2022 Sep 10;235(3):530-538. Epub 2022 Aug 10.

From the Division of Pediatric Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT.

Background: Current guidelines recommending preoperative transfusion to a hemoglobin level of 9 to 10 g/dL for patients with sickle cell disease (SCD) are based on imperfect evidence. The benefit of preoperative transfusion in children specifically is not known. This study aimed to evaluate whether preoperative RBC transfusion is associated with different rates of sickle cell crisis and surgical complications, compared with no preoperative transfusion, among children with SCD undergoing common abdominal operations. Read More

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September 2022

Atypical Presentation of Babesiosis With Neurological Manifestations as Well as Hematological Manifestations.

Cureus 2022 Jul 13;14(7):e26811. Epub 2022 Jul 13.

Internal Medicine, Einstein Medical Center Montgomery, East Norriton, USA.

Babesiosis is an infectious disease that is typically known to present with fevers, chills, and myalgias; and less commonly with anorexia, headache, nausea, and vomiting. The least common are shortness of breath, sore throat, neck stiffness, emotional lability, photophobia, and dark urine. Even more unusual are severe neurologic manifestations like altered mental status, motor deficits, and ataxia. Read More

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Autoimmune hemolytic anemia as an initial presentation in children with systemic lupus erythematosus: two case reports.

J Int Med Res 2022 Aug;50(8):3000605221115390

Department of Pediatrics, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, No. 261, Huansha Road, Hangzhou, Zhejiang Province People's Republic of China.

We report the cases of two children who presented with autoimmune hemolytic anemia (AIHA) as an initial presentation of systemic lupus erythematosus (SLE). Both patients had a positive Coombs test, anemia, and an increased number of spherocytes in their blood smear. The patient in Case 1 presented with fever, urticarial erythema, facial paresis, AIHA, and leucopenia. Read More

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RS12574989 and haplotype associated with α/β-chain imbalance and population HbA2 reduction.

BMC Med Genomics 2022 Aug 15;15(1):179. Epub 2022 Aug 15.

Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, The Third Affiliated Hospital of Guangzhou Medical University, No. 63 Duobao Road, Guangzhou, 510150, Guangdong, China.

Determining the associated relationship of genotype and phenomenon would benefit the understanding of disease and renew disease intervention means. 14,518 patients who underwent haemoglobin electrophoresis from June 2020 to December 2020 were enrolled in our study, and additional data including sex, age and routine blood examination results were collected. We focused on individuals with normal red blood cell indices and no common thalassemia pathogenic mutation and selected three groups for the following study: the control group (2. Read More

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Endothelial VWF is critical for the pathogenesis of vaso-occlusive episode in a mouse model of sickle cell disease.

Proc Natl Acad Sci U S A 2022 Aug 15;119(34):e2207592119. Epub 2022 Aug 15.

Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.

Vaso-occlusive episode (VOE) is a common and critical complication of sickle cell disease (SCD). Its pathogenesis is incompletely understood. von Willebrand factor (VWF), a multimeric plasma hemostatic protein synthesized and secreted by endothelial cells and platelets, is increased during a VOE. Read More

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[Congenital hemolytic anemia caused by a new mutation of ATP11C gene: a case report].

Zhonghua Xue Ye Xue Za Zhi 2022 Jun;43(6):528

The First Hospital of Hebei Medical University, Shijiazhuang 050030, China.

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[Recent progress in the diagnosis and treatment of cold agglutinin disease].

J Q Liu F K Zhang

Zhonghua Xue Ye Xue Za Zhi 2022 Jun;43(6):524-528

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.

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Safety and efficacy of mitapivat, an oral pyruvate kinase activator, in adults with non-transfusion dependent α-thalassaemia or β-thalassaemia: an open-label, multicentre, phase 2 study.

Lancet 2022 08;400(10351):493-501

Division of Hematology, University of California San Francisco Benioff Children's Hospital, Oakland, CA, USA.

Background: Patients with non-transfusion-dependent thalassaemia (NTDT), although they do not require regular blood transfusions for survival, can still accrue a heavy burden of comorbidities. No approved disease-modifying therapies exist for these patients. We aimed to investigate the safety and efficacy of mitapivat (Agios Pharmaceuticals, Cambridge, MA, USA), a pyruvate kinase activator, in adults with non-transfusion-dependent (NTD) α-thalassaemia or NTD β-thalassaemia. Read More

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An energy booster for thalassaemic red blood cells.

Antonis Kattamis

Lancet 2022 08;400(10351):470-471

Division of Paediatric Haematology-Oncology, First Department of Paediatrics, National and Kapodistrian University of Athens School of Medicine, Athens 11527, Greece. Electronic address:

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Skin ulcers as a complication of short-term use of phenazopyridine in an old man: A case report.

J Infect Chemother 2022 Aug 10. Epub 2022 Aug 10.

Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Introduction: Phenazopyridine is an azo dye, which exerts local anesthetic or analgesic action on urinary tract mucosa through an unknown mechanism. Besides its common complications including orange discoloration of the urine and gastrointestinal problems, it may have rare side effects like hemolytic anaemia, methemoglobinemia, renal failure, and skin changes. We reported a paraplegic man with skin ulcers on scretom and right foot after about 3 days of phenazopyridine use CASE REPORT: A 62-year-old man presented with flesh shaped deep ulcers in lower parts of the body. Read More

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Effectiveness of aspirin vs. clopidogrel in dogs with immune mediated haemolytic anaemia evaluated by serial thromboelastography and platelet mapping.

Vet J 2022 Aug 10:105882. Epub 2022 Aug 10.

Sydney School of Veterinary Science, Faculty of Science, University of Sydney, Sydney, Australia; Department of Veterinary Clinical Sciences, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong, China.

Most dogs with immune mediated haemolytic anaemia (IMHA) are hypercoagulable, as measured by thromboelastography (TEG). Thromboelastography-platelet mapping (TEG-PM) has been used to assess platelet function in human patients treated with aspirin or clopidogrel. The aim of this study was to compare platelet thromboxane A-receptor inhibition (TXARI) and platelet adenosine diphosphate (ADP)-receptor inhibition (ADP-RI) as measured by TEG-PM in dogs with primary IMHA receiving aspirin or clopidogrel to determine if TEG-PM might be useful to monitor treatment. Read More

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Molecular detection of Mycoplasma wenyonii and its closely related hemotropic Mycoplasma sp. in blood-sucking flies from a buffalo farm in Chachoengsao province, Thailand.

Acta Trop 2022 Aug 9;235:106647. Epub 2022 Aug 9.

Animal Vector-Borne Disease Research Unit, Parasitology Unit, Department of Veterinary Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address:

Bovine hemoplasmosis is a disease in buffaloes and cattle caused by hemotropic mycoplasmas or hemoplasmas. Only two bovine hemoplasma species, Mycoplasma wenyonii and Candidatus Mycoplasma haemobos, have been described in several countries. Hemoplasmas induce acute hemolytic anemia or chronic infection, leading to production loss. Read More

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Isolated Respiratory Failure as a Presentation for Early Perinuclear Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

Cureus 2022 Jul 9;14(7):e26698. Epub 2022 Jul 9.

Internal Medicine, Rutgers Health/Trinitas Regional Medical Center, Elizabeth, USA.

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is an autoimmune inflammatory disease that usually affects the small-sized vasculature, most notably of the lungs and kidneys. One of the challenges of suspecting and diagnosing the condition lies in the insidious and unclear symptoms of presentation. In this case report, we discuss the case of a patient who initially presented with solely unclear pulmonary symptoms, without other organ system dysfunction. Read More

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Early-Onset Diabetes Mellitus in Chromosome 8p11.2 Deletion Syndrome Combined With Becker Muscular Dystrophy - A Case Report.

Front Endocrinol (Lausanne) 2022 25;13:914863. Epub 2022 Jul 25.

Department of Endocrinology and Metabolism, Institute of Endocrinology, National Health Commission (NHC) Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China.

Background: Chromosome 8p11.2 includes several key genes in development such as the , , , and genes. Deletion of this fragment causes a contiguous gene syndrome. Read More

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Successful treatment of suspect -induced ARDS in a dog using lung-protective positive-pressure ventilation and neuromuscular blockade.

Clin Case Rep 2022 Aug 9;10(8):e6234. Epub 2022 Aug 9.

Department of Clinical Sciences Cummings School of Veterinary Medicine, Tufts University North Grafton Massachusetts USA.

A mixed breed dog was treated for severe hemolytic anemia secondary to infection. Within 14 hours of hospitalization, the dog developed respiratory distress and hypoxemia. The patient improved with lung-protective mechanical ventilation and neuromuscular blockade. Read More

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Global longitudinal strain for detection of cardiac iron overload in patients with thalassemia: a meta-analysis of observational studies with individual-level participant data.

Cardiovasc Ultrasound 2022 Aug 12;20(1):22. Epub 2022 Aug 12.

Gabriele Monasterio Foundation, Tuscan Region, Pisa, Italy.

Background: Although cardiac magnetic resonance (CMR) is the most reliable tool for assessment of CIO in patients with thalassemia, it is not always readily available. Recent studies have explored the potential of GLS as an alternative for diagnosis of CIO. We aimed to investigate the efficacy of global longitudinal strain (GLS) for detection of cardiac iron level (CIO). Read More

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Methodologies and tools to shed light on erythrophagocytosis.

Biochimie 2022 Aug 8. Epub 2022 Aug 8.

Université de La Réunion, INSERM, UMR 1188 Diabète Athérothrombose Thérapies Réunion Océan Indien (DéTROI), Saint-Denis de La Réunion, France. Electronic address:

Red blood cells (RBC) are the most abundant circulating cell of the human body. RBC are constantly exposed to multiple stresses in the circulation, leading to molecular and structural impairments and death. The physiological process of RBC senescence or ageing is referred to as eryptosis. Read More

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Thalassemia in Thailand.

Hemoglobin 2022 Jan;46(1):53-57

Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand.

Thailand has a population of 66.2 million with 30.0-40. Read More

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January 2022