76,661 results match your criteria Hemolytic Anemia


Frequency and causes of anemia in Lymphoma patients.

Pak J Med Sci 2019 Jan-Feb;35(1):61-65

Dr. Neelam Siddiqui, MRCP, FRCP, CCST (Medical Oncology), Consultant Oncologist, Department of Medical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.

Objective: Purpose of this study was to find out frequency of anemia and its causes in newly diagnosed treatment naive lymphoma patients.

Methods: We retrospectively studied all lymphoma patients (> 18 years age) diagnosed and treated at Shaukat Khanum Memorial Cancer Hospital and Research Centre, from January 2016 till January 2017. The data was collected from electronic Hospital Information System. Read More

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http://dx.doi.org/10.12669/pjms.35.1.91DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408630PMC

Unusually Low Serum Alkaline Phosphatase Activity in a Patient with Acute on Chronic Liver Failure and Hemolysis.

EJIFCC 2019 Mar 1;30(1):99-105. Epub 2019 Mar 1.

Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India.

A 28-year-old male with acute on chronic liver failure (ACLF) and hepatic encephalopathy had deranged liver function with curiously low level (0-15 IU/L) of serum alkaline phosphatase (ALP). Peripheral smear examination suggested hemolytic anemia. The finding of persistent low ALP, after ruling out pre-analytical causes, in ACLF has been reported in Wilson's disease (WD) with/ without autoimmune hemolytic anemia (AIHA). Read More

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Outcomes and treatment strategies for autoimmunity and hyperinflammation in patients with RAG deficiency.

J Allergy Clin Immunol Pract 2019 Mar 12. Epub 2019 Mar 12.

Division of Allergy and Immunology, Massachusetts General Hospital for Children, Boston, MA, USA. Electronic address:

Background: While autoimmunity and hyperinflammation secondary to recombinase activating gene (RAG) deficiency have been associated with delayed diagnosis and even death, our current understanding is limited primarily to small case series.

Objective: Understand the frequency, severity, and treatment responsiveness of autoimmunity and hyperinflammation in RAG deficiency.

Methods: In reviewing the literature and our own database, we identified 85 patients with RAG deficiency, reported between 2001 and 2016, and compiled the largest case series to date of 63 patients with prominent autoimmune and/or hyperinflammatory pathology. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.02.038DOI Listing

Severe Fetal Hemolysis and Cholestasis Due to High-Titer Maternal IgG Anti-A Antibodies.

Pediatrics 2019 Mar 14. Epub 2019 Mar 14.

Department of Experimental Immunohematology, Sanquin, Amsterdam, Netherlands.

ABO blood group incompatibility between mother and fetus can lead to hemolytic disease of the fetus and newborn (HDFN). We present the first case of severe O/A HDFN associated with extremely high-titer (1:32 000) immunoglobulin G anti-A antibodies in a Cameroon mother. Cord blood analysis revealed severe fetal hemolytic anemia and conjugated hyperbilirubinemia. Read More

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http://pediatrics.aappublications.org/lookup/doi/10.1542/ped
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http://dx.doi.org/10.1542/peds.2018-2859DOI Listing
March 2019
2 Reads

The tolerability of single low dose primaquine in glucose-6-phosphate deficient and normal falciparum-infected Cambodians.

BMC Infect Dis 2019 Mar 12;19(1):250. Epub 2019 Mar 12.

Mahidol Oxford Tropical Medicine Research unit (MORU), 420/60 Rajvithi Road, Bangkok, 10400, Thailand.

Background: The WHO recommends single low-dose primaquine (SLDPQ, 0.25 mg/kg body weight) in falciparum-infected patients to block malaria transmission and contribute to eliminating multidrug resistant Plasmodium falciparum from the Greater Mekong Sub region (GMS). However, the anxiety regarding PQ-induced acute haemolytic anaemia in glucose-6-phosphate dehydrogenase deficiency (G6PDd) has hindered its use. Read More

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http://dx.doi.org/10.1186/s12879-019-3862-1DOI Listing
March 2019
1 Read

[Immuno-hematological follow up of pregnant women].

Rev Prat 2018 May;68(5):541-546

Unité clinique du centre national de référence en hémobiologie périnatale, service de médecine foetale, pôle ORGYNE, hôpital Trousseau, AP-HP, Paris, France.

Immuno-hematological follow up of pregnant women. The goal of immuno-hematological follow-up during pregnancy is to organize maternal transfusion safety and optimal management of fetal and neonatal hemolytic disease, that may result from maternal immunization. This follow-up relies on scheduled antibodies detection following regulation. Read More

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May 2018
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Features, reason for testing, and changes with time of 583 paroxysmal nocturnal hemoglobinuria clones from 529 patients: a multicenter Italian study.

Ann Hematol 2019 Mar 13. Epub 2019 Mar 13.

CEINGE Biotecnologie Avanzate, Naples, Italy.

In this study, we aimed at disclosing the main features of paroxysmal nocturnal hemoglobinuria (PNH) clones, their association with presentation syndromes, and their changes during follow-up. A large-scale, cooperative collection (583 clones from 529 patients) of flow cytometric and clinical data was entered into a national repository. Reason for testing guidelines were provided to the 41 participating laboratories, which followed the 2010 technical recommendations for PNH testing by Borowitz. Read More

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http://dx.doi.org/10.1007/s00277-019-03644-8DOI Listing
March 2019
1 Read

[Blood Transfusion: a Guide to Clinical Decision Making].

Anasthesiol Intensivmed Notfallmed Schmerzther 2019 Mar 13;54(3):194-205. Epub 2019 Mar 13.

Nowadays, management of hemotherapy is regulated in Germany by the transfusion act and several guidelines while the transfusing physician is responsible for correct implementation at the bedside. Indications for blood products have to be carefully adapted to the patient's current clinical situation and pre-existing diseases have to be considered as well. Today, for most perioperative elective surgeries, evidence-based transfusion thresholds for packed red blood cell concentrates (RBC) have been defined and should be considered. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0593-4390
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http://dx.doi.org/10.1055/a-0593-4390DOI Listing
March 2019
2 Reads

Etoricoxib-induced immune hemolytic anemia: first case presenting acute kidney failure.

Transfusion 2019 Mar 13. Epub 2019 Mar 13.

Hospital Italiano de Buenos Aires. Transfusion Medicine Service, Buenos Aires, Argentina.

Background: Etoricoxib is a selective inhibitor of cyclooxygenase 2 used mainly to treat osteoarticular pain. Here, we report the case of a patient who developed acute kidney failure and immune hemolytic anemia after the use of etoricoxib.

Study Design And Methods: An 83-year-old female patient developed immune hemolytic anemia and acute kidney failure after treatment with etoricoxib for articular pain. Read More

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http://dx.doi.org/10.1111/trf.15226DOI Listing

Etiology and Outcomes of Thrombotic Microangiopathies.

Clin J Am Soc Nephrol 2019 Mar 12. Epub 2019 Mar 12.

Service de Néphrologie-hypertension, Dialyses, Transplantation Rénale, Hôpital Bretonneau et hôpital Clocheville,

Background And Objectives: Thrombotic microangiopathies constitute a diagnostic and therapeutic challenge. Secondary thrombotic microangiopathies are less characterized than primary thrombotic microangiopathies (thrombotic thrombocytopenic purpura and atypical hemolytic and uremic syndrome). The relative frequencies and outcomes of secondary and primary thrombotic microangiopathies are unknown. Read More

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http://dx.doi.org/10.2215/CJN.11470918DOI Listing
March 2019
2 Reads

Presentation of hemolytic and hemorrhagic rangeliosis in Cerdocyon thous.

Ticks Tick Borne Dis 2019 Feb 22. Epub 2019 Feb 22.

Laboratório de Diagnóstico em Medicina Veterinária, Universidade de Caxias do Sul, R. Francisco Getúlio Vargas, 1130, Petrópolis, Caxias do Sul, RS, 95070560, Brazil. Electronic address:

Rangeliosis, caused by protozoan Rangelia vitalii, is transmitted by the tick Amblyomma aureolatum. The disease is characterized by hemolytic and hemorrhagic disorder and has been described in dogs and other wild canids. The aim of this study was to compare clinicopathological findings and laboratory results of a Rangelia infection in a crab-eating fox (Cerdocyon thous) with those of canine rangeliosis. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2019.02.010DOI Listing
February 2019
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Identification and functional analyses of disease-associated P4-ATPase phospholipid flippase variants in red blood cells.

J Biol Chem 2019 Mar 8. Epub 2019 Mar 8.

Biochemistry & Molecular Biology, University of British Columbia, Canada.

ATP-dependent phospholipid flippase activity crucial for generating lipid asymmetry was first detected in red blood cell (RBC) membranes, but the P4-ATPases responsible have not been directly determined. Using affinity-based mass spectrometry, we show that ATP11C is the only abundant P4-ATPase phospholipid flippase in human RBCs, whereas ATP11C and ATP8A1 are the major P4-ATPases in mouse RBCs. We also found that ATP11A and ATP11B are present at low levels. Read More

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http://dx.doi.org/10.1074/jbc.RA118.007270DOI Listing
March 2019
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ACVIM consensus statement on the treatment of immune-mediated hemolytic anemia in dogs.

J Vet Intern Med 2019 Mar 7. Epub 2019 Mar 7.

Davies Veterinary Specialists, Manor Farm Business Park, Huntingdon, United Kingdom.

Immune-mediated hemolytic anemia (IMHA) causes severe anemia in dogs and is associated with considerable morbidity and mortality. Treatment with various immunosuppressive and antithrombotic drugs has been described anecdotally and in previous studies, but little consensus exists among veterinarians as to the optimal regimen to employ and maintain after diagnosis of the disease. To address this inconsistency and provide evidence-based guidelines for treatment of IMHA in dogs, we identified and extracted data from studies published in the veterinary literature. Read More

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http://dx.doi.org/10.1111/jvim.15463DOI Listing
March 2019
1 Read

Sickle cell diseases: What can nuclear medicine offer?

Hell J Nucl Med 2019 Mar 5. Epub 2019 Mar 5.

Nuclear Medicine Unit, Interdisciplinary Department of Medicine, University of Bari "Aldo Moro", Bari, Italy.

Sickle cell disease (SCD) is the best known haemoglobinopathy, caused by a mutation substituting valina for glutamic acid at position 6 of the beta-globin chain of adult hemoglobin A, resulting in hemoglobin S (HbS). The homozygous HbS disease (HbSS), an autosomal recessive disorder, is the most common form and the Mediterranean area, along with sub-Saharian African and India, have the highest prevalence (1%-15%). In particular, Sicily with a prevalence of 2%-5%, is among the most interested regions. Read More

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http://dx.doi.org/10.1967/s002449910950DOI Listing
March 2019
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A Comparison Of Skeletal Age Of Thalassaemic Patients Of 9-15 Years With Chronological Age By Radiography.

J Ayub Med Coll Abbottabad 2018 Oct-Dec;30(Suppl 1)(4):S642-S646

Department of Anatomy, Bacha Khan Medical College, Mardan, Pakistan.

Background: Thalassemia is inherited disorder characterized by haemolytic anaemia, due to complete absence or reduced β-globin chain synthesis, stimulating pathological bone marrow overstimulation and altered erythropoiesis. The change in bone mass ultimately results into miss interpretation of bone age once assed from x-ray radiograph. The aims compare skeletal age of thalassaemic children of 9-15 years with chronological age by x-ray wrist bones. Read More

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March 2019
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Diagnostic and Treatment Challenges of Paroxysmal Nocturnal Hemoglobinuria in Uganda.

Case Rep Hematol 2019 31;2019:7897509. Epub 2019 Jan 31.

Department of Internal Medicine, Mbarara University of Science and Technology (MUST), Mbarara, Uganda.

Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a very rare disorder of the hematopoietic stem cells which is often underdiagnosed. Its incidence is about 5 cases per million inhabitants in a year, and currently, there are only 1610 patients in the International PNH Registry. In this report, we describe a case of PNH in southwestern Uganda. Read More

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http://dx.doi.org/10.1155/2019/7897509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374880PMC
January 2019
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Ceftriaxone-Induced Immune Hemolytic Anemia: In Vitro Reversal with Peptide Inhibitor of Complement C1 (PIC1).

Case Rep Hematol 2019 30;2019:4105653. Epub 2019 Jan 30.

Department of Pediatrics, Eastern Virginia Medical School, 700 West Olney Road, Norfolk, VA 23507, USA.

We report a case of ceftriaxone-induced immune hemolytic anemia in a 10-year-old with chronic active Epstein-Barr virus disease and hemophagocytic lymphohistiocytosis. After chemotherapy, she became febrile and received ceftriaxone. She rapidly developed respiratory failure and anemia. Read More

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http://dx.doi.org/10.1155/2019/4105653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374879PMC
January 2019
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Differential miRNA expression profile and proteome in plasma exosomes from patients with paroxysmal nocturnal hemoglobinuria.

Sci Rep 2019 Mar 5;9(1):3611. Epub 2019 Mar 5.

Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Arrixaca, Murcia, Spain.

Paroxysmal Nocturnal Hemoglobinuria (PNH) is a clonal disease of blood cells caused by the lack of glycosyl phosphatidyl inositol anchored proteins bound to the cell membrane. In consequence, erythrocytes lead to intravascular hemolysis upon complement activation, which promotes high risk of thrombosis, intravascular hemolytic anemia, and bone marrow failure in patients. The mechanisms of thrombosis in PNH are still poorly understood. Read More

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http://dx.doi.org/10.1038/s41598-019-40453-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401143PMC
March 2019
1 Read

Catastrophic Antiphospholipid Syndrome Presenting as Congestive Heart Failure in a Patient with Thrombotic Microangiopathy.

Tex Heart Inst J 2019 02 1;46(1):48-52. Epub 2019 Feb 1.

Thrombotic microangiopathic syndromes are characterized by thrombus formation leading to microangiopathic hemolytic anemia, thrombocytopenia, and end-organ injury that most often affects the kidney and brain. Patients with thrombotic microangiopathy can also present with cardiac involvement, which has been shown to worsen their prognosis. We describe the case of a 46-year-old woman who presented with acute congestive heart failure as a manifestation of catastrophic antiphospholipid syndrome, which is characterized by rapidly progressing multiorgan involvement. Read More

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http://dx.doi.org/10.14503/THIJ-17-6472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379002PMC
February 2019
2 Reads

[Clinical features and laboratory data analysis of decreased glycosylated hemoglobin related to hemolytic disease].

Zhonghua Xue Ye Xue Za Zhi 2019 Feb;40(2):137-140

Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.

To compare the effects of different hemolytic diseases on the level of glycosylated hemoglobin (HbA(1c)) to further explore the relationship between HbA(1c) and laboratory indexes to disclose implications of HbA(1c) in hemolytic diseases. The distribution of 192 decreased HbA(1c) cases in 4 categories of hemolytic diseases was analyzed. Laboratory indexes related to hemolysis were tested and analyzed in each kind of disease, and relationship between laboratory indexes and HbA(1)c was statistically explored. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2019.02.008DOI Listing
February 2019

[Outcomes of splenectomy in relapsed/refractory autoimmune hemolytic anemia].

Zhonghua Xue Ye Xue Za Zhi 2019 Feb;40(2):132-136

Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.

To evaluate the outcomes of splenectomy in the treatment of relapsed/refractory autoimmune hemolytic anemia (AIHA). Retrospective analysis was performed in 30 cases with relapsed/refractory AIHA who were treated with splenectomy in our hospital. The pre- and post-operative blood routine indexes and responses were followed up. Read More

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http://www.hematoline.com/CN121090201902/1117649.htm
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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2019.02.007DOI Listing
February 2019
3 Reads

Autoimmune Hemolytic Anemia, Erythrophagocytosis and Liver Dysfunction After Cefixime Use for Urinary Tract Infection in a Child.

Indian J Hematol Blood Transfus 2019 Jan 1;35(1):203-204. Epub 2018 Sep 1.

2Department of Intensive Care Unit, Gazi University Medical Faculty, Ankara, Turkey.

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http://dx.doi.org/10.1007/s12288-018-1006-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369064PMC
January 2019
1 Read

Pembrolizumab-induced Autoimmune Hemolytic Anemia and Hemophagocytic Lymphohistiocytosis in Non-small Cell Lung Cancer.

Intern Med 2019 1;58(5):699-702. Epub 2019 Mar 1.

Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan.

We herein report a 78-year old man with squamous cell carcinoma of the lungs treated with pembrolizumab. At 10 days after the administration of pembrolizumab, he showed progressive anemia and increased levels of bilirubin. Because the findings of a direct coombs test and cold hemagglutinin were positive, we diagnosed the patient with autoimmune hemolytic anemia and treated him with prednisolone. Read More

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http://dx.doi.org/10.2169/internalmedicine.1001-18DOI Listing
March 2019
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Letter to the editor: Comments on 'A case of pembrolizumab-induced autoimmune haemolytic anaemia with polymyalgia rheumatica'.

Eur J Cancer 2019 Feb 28;111:59-60. Epub 2019 Feb 28.

Department of Rheumatology, Austin Health, Melbourne, Australia; Department of Medicine, University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1016/j.ejca.2018.11.034DOI Listing
February 2019
1 Read

Seizure as the Presenting Symptom for Atypical Hemolytic Uremic Syndrome.

J Emerg Med 2019 Feb 27. Epub 2019 Feb 27.

Geisel School of Medicine at Dartmouth, Hanover, New Hampshire and Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire.

Background: Atypical hemolytic uremic syndrome (aHUS) is a complement-mediated disease manifesting in thrombocytopenia, microangiopathic hemolytic anemia, and acute kidney injury. It has a higher incidence of extrarenal manifestations, including central nervous system findings like seizure or stroke, pancreatitis, and cardiac manifestations.

Case Report: We present a case of an unimmunized 14-month-old girl presenting with generalized seizure and ultimately diagnosed with aHUS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07364679183122
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http://dx.doi.org/10.1016/j.jemermed.2018.12.034DOI Listing
February 2019
2 Reads

Hematologic Complications of Immune Checkpoint Inhibitors.

Oncologist 2019 Feb 28. Epub 2019 Feb 28.

Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Immune checkpoint inhibitors have improved outcomes for patients with numerous hematological and solid cancers. Hematologic toxicities have been described, but the spectrum, timing, and clinical presentation of these complications are not well understood. We used the World Health Organization's pharmacovigilance database of individual-case-safety-reports (ICSRs) of adverse drug reactions, VigiBase, to identify cases of hematologic toxicities complicating immune checkpoint inhibitor therapy. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0574DOI Listing
February 2019
1 Read

Transient appearance of ring sideroblasts in peripheral blood in the acute phase of secondary hemolytic anemia.

Authors:
Fei Wang Geng Wang

Blood 2019 Feb;133(9):1000

Peking Union Medical College Hospital.

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http://dx.doi.org/10.1182/blood-2018-09-875013DOI Listing
February 2019
3 Reads

An update on glucose-6-phosphate dehydrogenase deficiency in children from Brazzaville, Republic of Congo.

Malar J 2019 Feb 28;18(1):57. Epub 2019 Feb 28.

Fondation Congolaise pour la Recherche Médicale (FCRM), Brazzaville, Republic of Congo.

Background: Malaria transmission-blocking anti-malarial drugs, such as primaquine, offers an effective strategy for reducing the incidence of falciparum malaria. However, this drug induces haemolytic anaemia among glucose-6-phosphate dehydrogenase (G6PD) deficient individuals. The distribution of G6PD deficiency in Brazzaville, Republic of Congo and the association of G6PD deficiency with haemoglobin levels and blood cell counts were investigated. Read More

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http://dx.doi.org/10.1186/s12936-019-2688-zDOI Listing
February 2019
1 Read

Transient Erythroblastopenia of Childhood: A Review for the Pediatric Emergency Medicine Physician.

Pediatr Emerg Care 2019 Mar;35(3):237-240

Assisstant Professor (Burns), Department of Pediatrics, Division of Pediatric Emergency Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA; Professor of Pediatrics (Woodward), Division Chief of Emergency Medicine, Department of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, WA.

Transient erythroblastopenia of childhood is a form of pure red cell aplasia that is self-limited and occurs in children 4 years old and younger. It is characterized by an absence or a significantly reduced quantity of erythroblasts in the bone marrow without underlying congenital red blood cell abnormalities. Transient erythroblastopenia of childhood should be considered in previously healthy children who present with normocytic anemia and lack of reticulocytosis without evidence of blood loss, hemolysis, or other causes of bone marrow suppression. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001760DOI Listing

Tolerability of erythrocyte ribavirin triphosphate concentrations depends on the ITPA genotype.

Ther Drug Monit 2019 Feb 26. Epub 2019 Feb 26.

Department of Clinical Pharmacy, Center for Clinical Pharmacy and Sciences, School of Pharmacy, Kitasato University.

Background: Ribavirin (RBV) is an antiviral drug that is part of the current standard therapy for chronic hepatitis C (CHC). It is enzymatically converted to ribavirin triphosphate (RTP) that inhibits the activity of viral RNA polymerase, thereby preventing viral replication. However, one of its adverse effects include hemolytic anemia that limits its application. Read More

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http://dx.doi.org/10.1097/FTD.0000000000000626DOI Listing
February 2019

Novel compound heterozygous mutations in the SPTA1 gene, causing hereditary spherocytosis in a neonate with Coombs‑negative hemolytic jaundice.

Mol Med Rep 2019 Feb 8. Epub 2019 Feb 8.

Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.

Hereditary spherocytosis (HS) is a common heterogeneous type of inherited hemolytic anemia characterized by jaundice and splenomegaly. Diagnosis of HS in neonates is considered unreliable, and is generally based on positive family history, spherocytes in peripheral smears, increased osmotic fragility, and jaundice. In the present study, routine laboratory tests, next‑generation sequencing, and Sanger sequencing were applied to diagnose a neonatal patient with Coombs‑negative hemolytic jaundice. Read More

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http://dx.doi.org/10.3892/mmr.2019.9947DOI Listing
February 2019
1 Read

Early Predictors of Renal Dysfunction in Pediatric Patients with Sickle Cell Disease.

Indian J Nephrol 2019 Jan-Feb;29(1):28-33

Department of Medical Microbiology and Immunology, Faculty of Medicine, Tanta University, Egypt.

Sickle cell disease (SCD) is a hereditary hemoglobinopathy characterized by abnormal hemoglobin production which leads to hemolytic anemia and intermittent occlusion of small blood vessels, which further leads to tissue ischemia, chronic organ damage, and organ dysfunction including urinary system. To measure the serum levels of cystatin-C and beta 2 microglobulin in pediatric patients with SCDand to investigate their significance as early biomarkers of glomerular and/or renal tubular dysfunction. This study was conducted among 70 children with SCD and 40 age and sex-matched children as a control group. Read More

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http://dx.doi.org/10.4103/ijn.IJN_40_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375016PMC
March 2019
1 Read

Treatment of Acute Kidney Injury in Hemolythic Uremic Syndrome (TTP).

Med Arch 2018 Dec;72(6):453-455

Clinic of Hemodialysis, Clinical Center University of Sarajevo, Bosnia and Herzegovina.

Introduction: Plasmapheresis is often used as a therapy in the treatment of thrombotic thrombocytopenic purpura (TTP). TTP is manifested in thrombotic microangiopathy, consumed thrombocytopenia, hemolytic anemia and acute kidney injury with HUS development, neurologic dysfunction, and fever.

Case Report: we will present a case of a patient with acute kidney injury and refractory TTP at the beginning of hospitalization, subsequently manifested in secondary nephrotic syndrome. Read More

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https://www.ejmanager.com/fulltextpdf.php?mno=302643874
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http://dx.doi.org/10.5455/medarh.2018.72.453-455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340615PMC
December 2018
6 Reads

Recurrent Non-immune Fetal Hydrops Associated With IPEX Syndrome.

Pediatr Dev Pathol 2019 Feb 27:1093526619834809. Epub 2019 Feb 27.

1 Department of Pathology and Laboratory Medicine, NorthShore University HealthSystem, Evanston, Illinois.

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) is a clinical syndrome associated with mutations in FOXP3 and consequent abnormalities of T regulatory cells. Affected males typically die in infancy or early childhood from a variety of autoimmune conditions. Reports of recurrent pregnancy loss of male fetuses in these families have been accompanied by descriptions of nonimmune fetal hydrops, with or without additional fetal anomalies. Read More

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http://dx.doi.org/10.1177/1093526619834809DOI Listing
February 2019
1 Read

Low Incidence of Hospital-Onset Infection in Sickle Cell Disease.

N Engl J Med 2019 02;380(9):887-888

New York Medical College, Valhalla, NY

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http://dx.doi.org/10.1056/NEJMc1815711DOI Listing
February 2019
1 Read
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Prevalence of autoimmune diseases and clinical significance of autoantibody profile: data from National Institute of Hygiene in Rabat, Morocco.

Hum Immunol 2019 Feb 23. Epub 2019 Feb 23.

Mohammed V University of Rabat, Faculty of sciences, Department of biology, Genomic Center of Human Pathologies, Laboratory of human Pathologies Biology and Faculty of Medicine, Rabat ,Morocco.

Aim: The objective of this study was to explore the prevalence of various autoimmune diseases (AIDs) in a large cohort of patients and to characterize the autoantibody profile in the patients with and without AIDs to confirm the diagnosis and to refine the Moroccan databases.

Patients And Method: Retrospective study was conducted in the Laboratory of autoimmunity National Institute of Hygiene (NIH) of Rabat in Morocco. A total of 3182 consecutive Moroccan patients (2183 females and 999 males) whose sera were tested for 14 autoantibody profile between 2010 and 2016. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.02.012DOI Listing
February 2019
3 Reads

Knowledge Deficit of Sickle Cell Trait Status: Can Nurses Help?

Authors:
Afua O Arhin

Crit Care Nurs Q 2019 Apr/Jun;42(2):198-201

School of Nursing, Fayetteville State University, Fayetteville, North Carolina.

Sickle cell disease and sickle cell trait are identified through universal newborn screening, which has been implemented in all hospitals across the United States since the 1970s. Yet, studies report that only 16% of Americans with sickle cell trait know their status. Despite these striking statistics, there appears to be no standardized methods for reporting positive sickle cell trait results of newborn screening to doctors or families of affected persons. Read More

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http://dx.doi.org/10.1097/CNQ.0000000000000254DOI Listing
March 2019
1 Read

ACVIM consensus statement on the diagnosis of immune-mediated hemolytic anemia in dogs and cats.

J Vet Intern Med 2019 Feb 26. Epub 2019 Feb 26.

Royal Veterinary College, University of London, London, United Kingdom.

Immune-mediated hemolytic anemia (IMHA) is an important cause of morbidity and mortality in dogs. IMHA also occurs in cats, although less commonly. IMHA is considered secondary when it can be attributed to an underlying disease, and as primary (idiopathic) if no cause is found. Read More

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http://doi.wiley.com/10.1111/jvim.15441
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http://dx.doi.org/10.1111/jvim.15441DOI Listing
February 2019
45 Reads

Potentiation of complement regulator factor H protects human endothelial cells from complement attack in aHUS sera.

Blood Adv 2019 Feb;3(4):621-632

Department of Immunopathology, Sanquin Research, and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Mutations in the gene encoding for complement regulator factor H (FH) severely disrupt its normal function to protect human cells from unwanted complement activation, resulting in diseases such as atypical hemolytic uremic syndrome (aHUS). aHUS presents with severe hemolytic anemia, thrombocytopenia, and renal disease, leading to end-stage renal failure. Treatment of severe complement-mediated disease, such as aHUS, by inhibiting the terminal complement pathway, has proven to be successful but at the same time fails to preserve the protective role of complement against pathogens. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018025692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391659PMC
February 2019
2 Reads

The prevalence and prognostic significance of autoimmune cytopenias in a cohort of Egyptian patients with chronic lymphocytic leukemia.

Hematol Oncol Stem Cell Ther 2019 Feb 20. Epub 2019 Feb 20.

The Hematology Unit, Oncology Center, Mansoura University, Mansoura, Egypt. Electronic address:

Objective/background: The impact of autoimmune cytopenias (AICs) on the chronic lymphocytic leukemia (CLL) clinical course and its prognostic significance remain a matter of controversial debate. This could be due to exclusion of patients with cytopenia from most clinical trials for this particular complication and the lack of standard diagnostic criteria and treatment approaches. We herein evaluate the prevalence and the prognostic significance of AICs among patients with CLL. Read More

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http://dx.doi.org/10.1016/j.hemonc.2019.01.004DOI Listing
February 2019
2 Reads

Efficacy of L-carnitine on ribavirin-induced hemolytic anemia in patients with hepatitis C virus infection.

Clin Mol Hepatol 2019 Feb 25. Epub 2019 Feb 25.

Division of Gastroenterology and Hepatology, Third Department of Internal Medicine, Nara Medical University, Nara, Japan.

Background/aims: L-carnitine not only alleviates hyperammonemia and reduces muscle cramps in patients with liver cirrhosis, but also improves anemia in patients with chronic hepatitis and renal dysfunction. This study prospectively evaluated the preventative efficacy of L-carnitine supplementation against hemolytic anemia during antiviral treatment using ribavirin in patients with hepatitis C virus (HCV)-related chronic liver disease.

Methods: A total of 41 patients with chronic hepatitis were consecutively enrolled in this study. Read More

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http://dx.doi.org/10.3350/cmh.2018.0070DOI Listing
February 2019
2 Reads

Interactions of an Anti-Sickling Drug with Hemoglobin in Red Blood Cells from a Patient with Sickle Cell Anemia.

Bioconjug Chem 2019 Feb 28. Epub 2019 Feb 28.

Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research , Food and Drug Administration (FDA) , Silver Spring , Maryland 20993 , United States.

The pathophysiology associated with sickle cell disease (SCD) includes hemolytic anemia, vaso-occlusive events, and ultimately end organ damage set off by the polymerization of deoxygenated hemoglobin S (HbS) into long fibers and sickling of red blood cells (RBCs). One approach toward mitigating HbS polymerization is to pharmacologically stabilize the oxygenated (R) conformation of HbS and thereby reduce sickling frequency and SCD pathology. GBT440 is an α-subunit-specific modifying agent that has recently been reported to increase HbS oxygen binding affinity and consequently delay in vitro polymerization. Read More

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http://dx.doi.org/10.1021/acs.bioconjchem.9b00130DOI Listing
February 2019
4 Reads

Treatment of Chemotherapy-Induced Thrombotic Microangiopathy with Eculizumab in a Patient with Metastatic Breast Cancer.

Case Rep Oncol 2019 Jan-Apr;12(1):1-6. Epub 2019 Jan 3.

Dialysis Center Ludwigsburg, Ludwigsburg, Germany.

The unexpected occurrence of thrombotic microangiopathy (TMA), characterised by microangiopathic haemolytic anaemia and thrombocytopenia, in a patient with cancer requires urgent diagnosis and appropriate management. TMA in patients with metastatic cancer can be a manifestation of the malignancy itself or a therapeutic complication. Distinguishing the cause of TMA is complicated but clinically important to initiate appropriate treatment of metastatic cancer and avoid potential drug toxicity. Read More

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http://dx.doi.org/10.1159/000495031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381888PMC
January 2019
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Clinical and laboratory features of autoimmune hemolytic anemia associated with immune checkpoint inhibitors.

Am J Hematol 2019 Feb 20. Epub 2019 Feb 20.

Division of Renal Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

Immune checkpoint inhibitors (ICPis) are a novel class of immunotherapeutic agents that have revolutionized the treatment of cancer; however, these drugs can also cause a unique spectrum of autoimmune toxicity. Autoimmune hemolytic anemia (AIHA) is a rare, but often severe, complication of ICPis. We identified 14 patients from nine institutions across the United States who developed ICPi-AIHA. Read More

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http://dx.doi.org/10.1002/ajh.25448DOI Listing
February 2019
3 Reads

Spontaneous Tumor Lysis Syndrome as Presenting Sign of Metastatic Prostate Cancer.

Cureus 2018 Dec 8;10(12):e3706. Epub 2018 Dec 8.

Hematology, Thomas Jefferson University Hospital, Philadelphia, USA.

Spontaneous tumor lysis syndrome is an exceedingly rare manifestation of metastatic prostate cancer. It can masquerade as thrombotic thrombocytopenic purpura (TTP) or complement-mediated hemolytic uremic syndrome (HUS). These entities present with microangiopathic hemolytic anemia, thrombocytopenia, and renal failure, and improve with the initiation of plasma exchange and steroids. Read More

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http://dx.doi.org/10.7759/cureus.3706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373879PMC
December 2018

CD5 B lymphocytes secrete IL-10 rather than TGF-β1 which control the immune response in autoimmune haemolytic anaemia/Evans syndrome.

Autoimmunity 2019 Feb 20:1-9. Epub 2019 Feb 20.

a Department of Hematology , General Hospital Tianjin Medical University , Tianjin , China.

Objective: To investigate the quantity and secretion function of cytokines-secreted CD5 B lymphocytes in Autoimmune Haemolytic Anaemia (AIHA)/Evans syndrome (ES) patients.

Methods: Twenty-five untreated AIHA/ES patients, 28 remission AIHA/ES patients and 25 healthy controls (HCs) were enrolled in this study. The quantity of CD5B lymphocytes which produce interleukin-10 (IL-10) (CD5IL-10) and transforming growth factor (TGF-β1) (CD5TGF-β1) were detected by flow cytometry (FCM). Read More

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http://dx.doi.org/10.1080/08916934.2019.1576644DOI Listing
February 2019
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Rapid and reproducible characterization of sickling during automated deoxygenation in sickle cell disease patients.

Am J Hematol 2019 Feb 19. Epub 2019 Feb 19.

Laboratory of Clinical Chemistry & Hematology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

In sickle cell disease (SCD), sickle hemoglobin (HbS) polymerizes upon deoxygenation, resulting in sickling of red blood cells (RBCs). These sickled RBCs have strongly reduced deformability, leading to vaso-occlusive crises and chronic hemolytic anemia. To date, there are no reliable laboratory parameters or assays capable of predicting disease severity or monitoring treatment effects. Read More

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http://doi.wiley.com/10.1002/ajh.25443
Publisher Site
http://dx.doi.org/10.1002/ajh.25443DOI Listing
February 2019
6 Reads

De novo variants in HK1 associated with neurodevelopmental abnormalities and visual impairment.

Eur J Hum Genet 2019 Feb 18. Epub 2019 Feb 18.

Department of Pediatrics, Columbia University Medical Center, New York, NY, USA.

Hexokinase 1 (HK1) phosphorylates glucose to glucose-6-phosphate, the first rate-limiting step in glycolysis. Homozygous and heterozygous variants in HK1 have been shown to cause autosomal recessive non-spherocytic hemolytic anemia, autosomal recessive Russe type hereditary motor and sensory neuropathy, and autosomal dominant retinitis pigmentosa (adRP). We report seven patients from six unrelated families with a neurodevelopmental disorder associated with developmental delay, intellectual disability, structural brain abnormality, and visual impairments in whom we identified four novel, de novo missense variants in the N-terminal half of HK1. Read More

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http://dx.doi.org/10.1038/s41431-019-0366-9DOI Listing
February 2019
1 Read

Predictable and Unusual Adverse Effects of Immunosuppression in Pediatric Liver Transplant Patients.

Exp Clin Transplant 2019 01;17(Suppl 1):230-233

From the Department of Pediatric Gastroenterology,Gazi University Faculty of Medicine, Ankara, Turkey.

Objectives: Our aim was to determine potentially adverse effects of immunosuppressive protocols after liver transplantation in children.

Materials And Methods: The medical records of 60 children who underwent liver transplant retrospectively analyzed. Corticosteroid, tacrolimus, and mycophenolate mofetil were the primary immunosuppressive agents used in our center. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P81DOI Listing
January 2019
3 Reads

Clinical variability and molecular characterization of Hbs/Gγ (Aγδβ)0-thal and Hbs/HPFH in Indian sickle cell disease patients: AIIMS experience.

Hematology 2019 Dec;24(1):349-352

a Department of Hematology , All India Institute of Medical Sciences , New Delhi , India.

Introduction: In sickle cell disease (SCD) patients, among the predictors of survival, HbF levels play a significant role in lowering the morbidity and mortality. Coinheritance of δβ thalassemia and hereditary persistence of fetal hemoglobin (HPFH) may contribute to variable HbF levels in SCD patients, thus influencing their clinicopathological profile. Such cases are sparsely documented in the literature and thus, we screened the presence of δβ thalassemia and HPFH in 126 cases of SCD with high HbF. Read More

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https://www.tandfonline.com/doi/full/10.1080/16078454.2019.1
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http://dx.doi.org/10.1080/16078454.2019.1579985DOI Listing
December 2019
4 Reads
1.189 Impact Factor