291 results match your criteria Hemoglobinuria Paroxysmal Cold


Donath-Landsteiner test.

Immunohematology 2019 Jan;35(1):3-6

Medical Director of Donor Services, Associate Medical Director of Transfusion Medicine, Houston Methodist Hospital, Department of Pathology and Genomic Medicine, 6565 Fannin Street, MS 205, Houston, TX.

Conclusions: The Donath-Landsteiner (DL) test is a serologic test used to detect the presence of a biphasic hemolysin. This autoantibody is seen in patients with paroxysmal cold hemoglobinuria. The test relies on the characteristic cold binding of an IgG autoantibody with specificity to the P blood group antigen. Read More

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January 2019
6 Reads

Paroxysmal Cold Hemoglobinuria in an Adult with Respiratory Syncytial Virus.

Case Rep Hematol 2018 13;2018:7586719. Epub 2018 Nov 13.

Division of Hematology and Medical Oncology, Department of Medicine, Mount Sinai Beth Israel, Mount Sinai Hospital, New York, NY, USA.

Paroxysmal cold hemoglobinuria (PCH) is a rare form of cold autoimmune hemolytic anemia first discovered in the early 20th century in adults with tertiary syphilis. Today, it is more commonly seen in children as a life-threatening anemia during a viral upper respiratory tract infection (URI). Although respiratory syncytial virus (RSV) has previously been reported to cause PCH in a child, herein we present the first documented case in an adult. Read More

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http://dx.doi.org/10.1155/2018/7586719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257899PMC
November 2018
16 Reads

Case of Donath-Landsteiner haemolytic anaemia in an adult female.

BMJ Case Rep 2018 Nov 8;2018. Epub 2018 Nov 8.

Medicine, Nassau University Medical Center, East Meadow, New York, USA.

Donath-Landsteiner haemolytic anaemia (DLHA), also known as paroxysmal cold haemoglobinuria, is a very rare and difficult condition to diagnose as well as treat. Here, we present a case of a 55-year-old Hispanic woman who presented with severe intravascular haemolytic anaemia in the setting of a viral illness 2 weeks prior to presentation. Direct antiglobulin testing revealed mixed results: positive for either complement, IgG or both on various occasions which led to a battery of tests including the Donath-Landsteiner antibody testing which turned out positive establishing the diagnosis of DLHA. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22647
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http://dx.doi.org/10.1136/bcr-2018-226475DOI Listing
November 2018
18 Reads

Autoimmune hemolytic anemia.

Vnitr Lek Summer 2018;64(5):514-519

Autoimmune hemolytic anemia (AIHA) is caused by auto-antibodies directed against self red blood cell (RBC) surface antigens. A consequence may be an intravascular hemolysis mediated by activated complement or extravascular hemolysis caused by destruction of complex of RBC with autoantibody in spleen and liver. The basic classification subdivides AIHA in primary/idiopathic and secondary with known underlying disease. Read More

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September 2018
12 Reads

Complement Activation and Inhibition in Autoimmune Hemolytic Anemia: Focus on Cold Agglutinin Disease.

Semin Hematol 2018 07 10;55(3):141-149. Epub 2018 Apr 10.

Department of Research and Innovation, Haugesund Hospital, Helse Fonna HF, Haugesund, Norway. Electronic address:

The classical complement pathway and, to some extent, the terminal pathway, are involved in the immune pathogenesis of autoimmune hemolytic anemia (AIHA). In primary cold agglutinin disease (CAD), secondary cold agglutinin syndrome and paroxysmal cold hemoglobinuria, the hemolytic process is entirely complement dependent. Complement activation also plays an important pathogenetic role in some warm-antibody AIHAs, especially when immunoglobulin M is involved. Read More

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http://dx.doi.org/10.1053/j.seminhematol.2018.04.002DOI Listing
July 2018
5 Reads

[Severe haemolytic anaemia and hepatitis in the course of Epstein-Barr virus infection].

Ugeskr Laeger 2018 Mar;180(10)

Epstein-Barr virus (EBV) is globally prevalent and in adolescents mostly observed as infectious mononucleosis. Abnormal liver blood tests are common, whereas more serious hepatitis is less prevalent. Autoimmune haemolytic anaemia may also occur in the course of this infection. Read More

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March 2018
9 Reads

Diagnostic difficulties in a patient with paroxysmal cold haemoglobinuria and acute kidney injury.

Cent Eur J Immunol 2017 30;42(4):404-406. Epub 2017 Dec 30.

Department of Paediatrics and Nephrology, Medical University of Warsaw, Poland.

Paroxysmal cold haemoglobinuria (PCH) is a form of autoimmune haemolytic anaemia (AIHA) characterised by a sudden onset of haemoglobinuria, either spontaneously or following exposure to cold. In children, it is commonly seen following a viral illness or after immunisation. Diagnosis of PCH is confirmed by a positive Donath Landsteiner (DL) test in which biphasic haemolysins are detected. Read More

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https://www.termedia.pl/doi/10.5114/ceji.2017.72816
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http://dx.doi.org/10.5114/ceji.2017.72816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820980PMC
December 2017
14 Reads

Microangiopathy and acute kidney injury in paroxysmal cold hemoglobinuria: A challenge for management.

Am J Hematol 2018 May 30;93(5):718-721. Epub 2018 Jan 30.

Department of Haematology, Royal Infirmary of Edinburgh, United Kingdom.

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http://dx.doi.org/10.1002/ajh.25038DOI Listing
May 2018
15 Reads

Inflammatory Breast Cancer and Warm Antibody Autoimmune Hemolytic Anemia: A Rare Paraneoplastic Syndrome.

J Investig Med High Impact Case Rep 2017 Oct-Dec;5(4):2324709617740905. Epub 2017 Nov 13.

East Tennessee State University, Johnson City, TN, USA.

Autoimmune hemolytic anemia (AIHA) is a disease process that involves the destruction of red blood cells mediated by the humoral immune system. It can be characterized as a cold agglutinin syndrome, paroxysmal cold hemoglobinuria, and warm, mixed type, and drug-induced AIHA. Although a well-established relationship exists between the presence of AIHA and lymphoproliferative malignancy, AIHA rarely presents in association with solid malignancies. Read More

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http://journals.sagepub.com/doi/10.1177/2324709617740905
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http://dx.doi.org/10.1177/2324709617740905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686882PMC
November 2017
15 Reads

Kids, colds, and complement: paroxysmal cold hemoglobinuria.

Authors:
Laura L Cooling

Transfusion 2017 06;57(6):1332-1335

Department of Pathology, University of Michigan, Ann Arbor, MI.

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http://dx.doi.org/10.1111/trf.14128DOI Listing
June 2017
8 Reads

Recurrent Donath-Landsteiner hemolytic anemia: a pediatric case report.

Transfusion 2017 06 31;57(6):1401-1406. Epub 2017 Mar 31.

Division of Pediatric Hematology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Background: Paroxysmal cold hemoglobinuria (PCH) is a form of autoimmune hemolytic anemia caused by the Donath-Landsteiner antibody (D-L antibody). In children, this is typically a transient immune-mediated hemolysis that follows a viral illness and does not recur. Recurrent acute or chronic PCH due to D-L antibody is very rare. Read More

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http://doi.wiley.com/10.1111/trf.14032
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http://dx.doi.org/10.1111/trf.14032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733778PMC
June 2017
13 Reads

Complementopathies.

Blood Rev 2017 07 6;31(4):213-223. Epub 2017 Feb 6.

Division of Hematology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address:

The complement system is an essential part of the innate immune system that requires careful regulation to ensure responses are appropriately directed against harmful pathogens, while preventing collateral damage to normal host cells and tissues. While deficiency in some components of the complement pathway is associated with increased susceptibility to certain infections, it has also become clear that inappropriate activation of complement is an important contributor to human disease. A number of hematologic disorders are driven by complement, and these disorders may be termed "complementopathies". Read More

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http://dx.doi.org/10.1016/j.blre.2017.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513767PMC
July 2017
49 Reads

The diagnosis and management of primary autoimmune haemolytic anaemia.

Br J Haematol 2017 02 22;176(3):395-411. Epub 2016 Dec 22.

Department of Haematology, Leeds Teaching Hospitals, Leeds, UK.

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http://dx.doi.org/10.1111/bjh.14478DOI Listing
February 2017
19 Reads

Immune Hemolytic Anemia (Paroxysmal Cold Hemoglobinuria) Preceding Burkitt Lymphoma in a 12-Year-Old Child.

J Pediatr Hematol Oncol 2017 01;39(1):e25-e26

Department of Pediatrics, Beaumont Children's Hospital, Oakland University William Beaumont School of Medicine, Royal Oak, MI.

Autoimmune hemolytic anemia (AIHA) in childhood, including paroxysmal cold hemoglobinuria, is an uncommon, potentially life-threatening disorder. AIHA is a recognized complication of several varieties of lymphoproliferative disorders, including high-grade B-cell lymphoma, but it has not been associated with Burkitt lymphoma in people without an underlying immunodeficiency. When AIHA occurs in association with lymphoproliferative disorders, it may precede or accompany the diagnosis of malignant disease or herald relapse. Read More

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http://dx.doi.org/10.1097/MPH.0000000000000714DOI Listing
January 2017
16 Reads

Paroxysmal cold hemoglobinuria: a difficult diagnosis in adult patients.

Transfusion 2017 01 2;57(1):137-143. Epub 2016 Nov 2.

Department of Medicine, McMaster University.

Background: Paroxysmal cold hemoglobinuria (PCH) is a rare form of autoimmune hemolytic anemia caused by a biphasic (Donath-Landsteiner [DL]) immunoglobulin G autoantibody. Estimates of disease frequency after syphilis are lacking and the diagnostic yield of testing for PCH is uncertain. The objectives of this study were: 1) to describe DL testing practices in Canada, 2) to determine how often a biphasic RBC antibody is detected in adults and children, and 3) to evaluate inter-rater reliability of interpretations of positive DL test results in adults. Read More

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http://dx.doi.org/10.1111/trf.13888DOI Listing
January 2017
21 Reads
3.230 Impact Factor

Occlusive Nonvasculitic Vasculopathy.

Am J Dermatopathol 2017 Sep;39(9):637-662

*Associate Staff of the Department of Dermatology, Department of Dermatology, Hospital Universitario de la Princesa, Universidad Autónoma, Madrid, Spain; †Associate Staff of the Department of Dermatology, Department of Dermatology, Fundación Jiménez Diaz, Universidad Autónoma, Madrid, Spain; ‡Director of Dermatopathology, Department of Dermatology, Hospital Clínico Universitario, Salamanca, Spain; §Director of Dermatopathology, Dermatopathology Research Unit, Medical University of Graz, Graz, Austria; ¶Director of Dermatopathology, Dermatopathologie Laboratory, Friedrichschafen, Germany; and ‖Chairman of the Department of Dermatology, Department of Dermatology, Hospital Clínico Universitario, Salamanca, Spain.

We review the most characteristic clinical and histopathologic findings of the cutaneous manifestations of the occlusive nonvasculitic vasculopathic disorders. Clinically, most of these conditions are characterized by retiform purpura. Histopathologic findings consist of occlusion of the vessel lumina with no vasculitis. Read More

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http://Insights.ovid.com/crossref?an=00000372-201709000-0000
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http://dx.doi.org/10.1097/DAD.0000000000000766DOI Listing
September 2017
91 Reads

Long-term follow-up of non-syphilitic paroxysmal cold hemoglobinuria in an adult.

Ann Hematol 2016 Sep 4;95(9):1547-9. Epub 2016 Jun 4.

Department of Hematology, Rinku General Medical Center, Izumisano, Osaka, Japan.

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http://dx.doi.org/10.1007/s00277-016-2717-8DOI Listing
September 2016
13 Reads

Paroxysmal cold hemoglobinuria in a child with RSV: an underrecognized cause of hemolytic anemia.

Am J Emerg Med 2016 Nov 23;34(11):2252.e5-2252.e6. Epub 2016 Apr 23.

Pediatrics, Texas Children's Hospital, 6621 Fannin St, Houston, TX, USA, 77030; Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, USA 77030. Electronic address:

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http://dx.doi.org/10.1016/j.ajem.2016.04.034DOI Listing
November 2016
12 Reads

The role of complement activation in thrombosis and hemolytic anemias.

Transfus Apher Sci 2016 Apr 25;54(2):191-8. Epub 2016 Apr 25.

Department of Medicine, Division of Hematology-Oncology, Weill Cornell Medicine-New York Presbyterian, New York, NY, USA.

Objective: The objective of this study was to describe complement activation in hemostatic and pathologic states of coagulation and in the acquired and congenital hemolytic anemias.

Methods And Results: We review published and emerging data on the involvement of the classic, alternative and lectin-based complement pathways in coagulation and the hemolytic anemias. The alternative pathway in particular is always "on," at low levels, and is particularly sensitive to hyper-activation in a variety of physiologic and pathologic states including infection, autoimmune disorders, thrombosis and pregnancy, requiring tight control predicated on a variety of soluble and membrane bound regulatory proteins. Read More

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http://dx.doi.org/10.1016/j.transci.2016.04.008DOI Listing
April 2016
8 Reads

Role of Complement in Autoimmune Hemolytic Anemia.

Transfus Med Hemother 2015 Sep 7;42(5):303-10. Epub 2015 Sep 7.

Department of Research and Development, Haugesund Hospital, Helse Fonna HF, Haugesund, Norway.

The classification of autoimmune hemolytic anemias and the complement system are reviewed. In autoimmune hemolytic anemia of the warm antibody type, complement-mediated cell lysis is clinically relevant in a proportion of the patients but is hardly essential for hemolysis in most patients. Cold antibody-mediated autoimmune hemolytic anemias (primary cold agglutinin disease, secondary cold agglutinin syndrome and paroxysmal cold hemoglobinuria) are entirely complement-mediated disorders. Read More

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http://dx.doi.org/10.1159/000438964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678321PMC
September 2015
7 Reads

Complement in hemolytic anemia.

Authors:
Robert A Brodsky

Hematology Am Soc Hematol Educ Program 2015 ;2015:385-91

Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.

Complement is increasingly being recognized as an important driver of human disease, including many hemolytic anemias. Paroxysmal nocturnal hemoglobinuria (PNH) cells are susceptible to hemolysis because of a loss of the complement regulatory proteins CD59 and CD55. Patients with atypical hemolytic uremic syndrome (aHUS) develop a thrombotic microangiopathy (TMA) that in most cases is attributable to mutations that lead to activation of the alternative pathway of complement. Read More

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http://dx.doi.org/10.1182/asheducation-2015.1.385DOI Listing
October 2016
8 Reads

Complement in hemolytic anemia.

Authors:
Robert A Brodsky

Blood 2015 Nov 18;126(22):2459-65. Epub 2015 Nov 18.

Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.

Complement is increasingly being recognized as an important driver of human disease, including many hemolytic anemias. Paroxysmal nocturnal hemoglobinuria (PNH) cells are susceptible to hemolysis because of a loss of the complement regulatory proteins CD59 and CD55. Patients with atypical hemolytic uremic syndrome (aHUS) develop a thrombotic microangiopathy (TMA) that in most cases is attributable to mutations that lead to activation of the alternative pathway of complement. Read More

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http://dx.doi.org/10.1182/blood-2015-06-640995DOI Listing
November 2015
60 Reads

[Autoimmune hemolytic anemia in children].

Transfus Clin Biol 2015 Oct-Dec;22(5-6):291-8. Epub 2015 Nov 10.

Laboratoire d'hématologie, hôpital d'Enfants Béchir Hamza de Tunis, Bab Saadoun, 1004 Jabbary, Tunis, Tunisie.

Autoimmune hemolytic anemia is a rare condition in children which differs from the adult form. It is defined by immune-mediated destruction of red blood cells caused by autoantibodies. Characteristics of the autoantibodies are responsible for the various clinical entities. Read More

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http://dx.doi.org/10.1016/j.tracli.2015.10.002DOI Listing
November 2016
9 Reads

[Hemolytic anemias and vitamin B12 deficieny].

Dtsch Med Wochenschr 2015 Aug 25;140(17):1302-10; quiz 1311-2. Epub 2015 Aug 25.

Hämato-onkologische Schwerpunktpraxis, Herrsching.

Hemolytic anemias consist of corpuscular, immun-hemolytic and toxic hemolytic anemias. Within the group of corpuscular hemolytic anemias, except for the paroxysmal nocturnal hemoglobinuria (PNH), all symptoms are caused by underlying heredetiary disorders within the red blood cell membran (hereditary spherocytosis), deficiencies of red cell enzymes (G6PDH- and pyrovatkinase deficiency) or disorders in the hemoglobin molecule (thalassaemia and sickle cell disease). Immune-hemolytic anemias are acquired hemolytic anemias and hemolysis is caused by auto- or allo-antibodies which are directed against red blood cell antigens. Read More

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http://dx.doi.org/10.1055/s-0041-103562DOI Listing
August 2015
18 Reads

Paroxysmal cold hemoglobinuria due to an IgA Donath-Landsteiner antibody.

Pediatr Blood Cancer 2015 Nov 5;62(11):2044-6. Epub 2015 Jun 5.

Department of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Paroxysmal cold hemoglobinuria (PCH) is an autoimmune hemolytic anemia (AIHA) characterized by the presence of a Donath-Landsteiner (D-L) antibody. PCH occurs most commonly in young children and is associated with acute, often self-limited hemolytic anemia. The D-L antibody is classically a biphasic IgG anti-P autoantibody identified by the D-L test. Read More

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http://dx.doi.org/10.1002/pbc.25591DOI Listing
November 2015
16 Reads

Paroxysmal cold hemoglobinuria.

Hematol Oncol Clin North Am 2015 Jun 7;29(3):473-8. Epub 2015 Mar 7.

Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine, Suite 4500, 301 building 4940 Eastern Ave, Baltimore, MD 21224, USA.

Paroxysmal cold hemoglobinuria is a rare cause of autoimmune hemolytic anemia predominantly seen as an acute form in young children after viral illnesses and in a chronic form in some hematological malignancies and tertiary syphilis. It is a complement mediated intravascular hemolytic anemia associated with a biphasic antibody against the P antigen on red cells. The antibody attaches to red cells at colder temperatures and causes red cell lysis when blood recirculates to warmer parts of the body. Read More

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http://dx.doi.org/10.1016/j.hoc.2015.01.004DOI Listing
June 2015
13 Reads

Red blood cell destruction in autoimmune hemolytic anemia: role of complement and potential new targets for therapy.

Biomed Res Int 2015 29;2015:363278. Epub 2015 Jan 29.

Department of Immunology and Transfusion Medicine, Haugesund Hospital, Helse Fonna, P.O. Box 2170, 5504 Haugesund, Norway.

Autoimmune hemolytic anemia (AIHA) is a collective term for several diseases characterized by autoantibody-initiated destruction of red blood cells (RBCs). Exact subclassification is essential. We provide a review of the respective types of AIHA with emphasis on mechanisms of RBC destruction, focusing in particular on complement involvement. Read More

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http://dx.doi.org/10.1155/2015/363278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326213PMC
November 2015
16 Reads

Case report: paroxysmal cold hemoglobinuria presenting during pregnancy.

BMC Hematol 2015 13;15. Epub 2015 Feb 13.

Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA USA.

Background: Paroxysmal cold hemoglobinuria is caused by a biphasic IgG autoantibody that triggers complement-mediated intravascular hemolysis. Paroxysmal cold hemoglobinuria has not previously been reported to occur in association with pregnancy.

Case Presentation: We report a case of an 18 year old female who presented in early pregnancy with acute hemolytic anemia and a positive Donath-Landsteiner antibody test. Read More

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http://dx.doi.org/10.1186/s12878-015-0023-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334594PMC
February 2015
9 Reads

Serological findings in a child with paroxysmal cold haemoglobinuria.

Case Rep Med 2014 9;2014:316010. Epub 2014 Oct 9.

Hematology Department, Hematopoietic Transplant and Cellular Therapy Unit, Virgen de la Arrixaca Clinical University Hospital, IMIB-Arrixaca, University of Murcia, Carretera Madrid-Cartagena, s/n, El Palmar, 30120 Murcia, Spain.

PCH is a rare autoimmune hemolytic anemia (AIHA) but is one of the most common causes of AIAH in children. For the diagnosis, it is important to perform the appropriate methods of serological investigation and show the typical biphasic reaction. This is a case report of a child who presented with features of haemolysis and was diagnosed with PCH of this way. Read More

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http://dx.doi.org/10.1155/2014/316010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209786PMC
November 2014
16 Reads

Treatment of autoimmune hemolytic anemias.

Haematologica 2014 Oct;99(10):1547-54

U.O. Ematologia, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy

Autoimmune hemolytic anemia (AIHA) is a relatively uncommon disorder caused by autoantibodies directed against self red blood cells. It can be idiopathic or secondary, and classified as warm, cold (cold hemagglutinin disease (CAD) and paroxysmal cold hemoglobinuria) or mixed, according to the thermal range of the autoantibody. AIHA may develop gradually, or have a fulminant onset with life-threatening anemia. Read More

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http://dx.doi.org/10.3324/haematol.2014.114561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181250PMC
October 2014
19 Reads

Two case studies and a review of paroxysmal cold hemoglobinuria.

Lab Med 2014 ;45(3):253-8; quiz e92

Indiana Blood Center, Indianapolis, Indiana;

Paroxysmal cold hemoglobinuria (PCH) is an acquired hemolytic anemia caused by immunoglobulin G (IgG) antibodies that sensitize red blood cells (RBCs) at cold temperatures by fixing complement to the RBCs causing intravascular hemolysis on rewarming. PCH usually appears in young children as recurrent high fevers, chills, and passage of red-brown urine. The diagnostic test for PCH is the Donath-Landsteiner test, an in vitro assay for biphasic hemolysis. Read More

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http://dx.doi.org/10.1309/LMWD51B2KIFSBLBJDOI Listing
May 2016
14 Reads

Haemolytic anaemia--PNH type II cells presenting a diagnostic dilemma.

BMJ Case Rep 2014 Jun 4;2014. Epub 2014 Jun 4.

Department of Cardiology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.

A 28-year-old man presented with a history of intermittent haematuria over the past 10 years usually following fever episodes and requiring blood transfusions during the episodes. History of any thrombotic complications, chest pain or erectile dysfunction was not forthcoming. Examination revealed severe pallor with mild icterus and mild splenomegaly. Read More

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http://dx.doi.org/10.1136/bcr-2014-204174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054514PMC
June 2014
13 Reads

Diagnostic and therapeutic challenges of primary autoimmune haemolytic anaemia in children.

Arch Dis Child 2014 Jul 5;99(7):668-73. Epub 2014 Mar 5.

Autoimmune haemolytic anaemias (AIHAs) are extracorpuscular haemolytic anaemias produced by antierythrocyte autoantibodies which cause a shortened red blood cell life span. There are several reasons why the diagnosis and treatment of AIHAs in children represent a bigger challenge than in adult patients, including the presence of particular AIHA types, the uncertainty of serological tests and the limited clinical experience. All these facts have added up to a poor understanding and management of some topics in childhood AIHA. Read More

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http://dx.doi.org/10.1136/archdischild-2013-305748DOI Listing
July 2014
8 Reads

Paroxysmal cold hemoglobinuria caused by an IgM-class Donath-Landsteiner antibody.

Pediatr Int 2013 Oct;55(5):664-6

Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Yoshida, Japan.

We report on a 4-year-old boy who developed paroxysmal cold hemoglobinuria (PCH) following the first dose of a seven-valent pneumococcal conjugate vaccine. He was admitted because of dark urine after exposure to cold air. Laboratory tests indicated anemia, increased serum indirect bilirubin and lactate dehydrogenase, and decreased serum haptoglobin. Read More

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http://dx.doi.org/10.1111/ped.12110DOI Listing
October 2013
27 Reads

[Cold agglutinin disease -  no response to glucocorticoids and rituximab, what treatment is best for the 3rd line of therapy? Case report and review of the literature].

Vnitr Lek 2013 Sep;59(9):828-40

Acquired autoimmune haemolytic anaemia is divided according to the characteristics of immunoglobulin causing haemolysis. The most frequent are haemolytic anaemia with thermal antibodies. They bind to erythrocytes and initiate their destruction in the reticuloendothelial system cells, leading to extravascular haemolysis. Read More

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September 2013
9 Reads

Visceral leishmaniasis presenting with paroxysmal cold haemoglobinuria.

Blood Transfus 2014 Jan 3;12 Suppl 1:s141-3. Epub 2013 Jul 3.

Department of Cellular Biotechnologies and Haematology, Division of Haematology, "Sapienza" University, Rome, Italy.

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http://dx.doi.org/10.2450/2013.0034-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934238PMC
January 2014
11 Reads

Case report on a child with paroxysmal cold haemoglobinuria.

Indian J Hematol Blood Transfus 2012 Jun 31;28(2):112-3. Epub 2011 Jul 31.

Faculty of Medicine, University of Sri Jayawardenapura, Gangodawila, Nugegoda, Sri Lanka.

PCH is one of the most common causes of acute AIHA in young children, although it affects patients of all ages. In children it is commonly seen following a viral illness or after immunization. Donath Landsteiner test is the diagnostic test. Read More

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http://dx.doi.org/10.1007/s12288-011-0094-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332278PMC
June 2012
9 Reads

Paroxysmal cold hemoglobinuria: a case report.

Immunohematology 2012 ;28(4):118-23

Department of Medical Laboratory, Imaging and Radiologic Sciences, Georgia Health Sciences University, Augusta, GA 30909, USA.

A 15-month-old white male child was admitted to the pediatric intensive care unit with symptoms of upper respiratory tract infection, increased somnolence, pallor, jaundice, fever, and decreased activity level. The purpose of this case study is to report the clinical findings associated with the patient's clinical symptoms and differential laboratory diagnosis. Read More

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June 2013
23 Reads

Florid erythrophagocytosis on the peripheral smear.

J Lab Physicians 2012 Jan;4(1):59-61

Department of Hematology, Apollo Hospitals, 21, Greams Lane, Off Greams Road, Chennai, Tamil Nadu, India.

Erythrophagocytosis is a relatively rare observation on blood smears. It has been reported in auto immune hemolytic anemias and sporadically in few other conditions. Here, we report a case of florid erythrophagocytosis with severe anemia following a viral infection in an 18-year-old girl. Read More

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http://dx.doi.org/10.4103/0974-2727.98679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425271PMC
January 2012
7 Reads

Erythrophagocytosis by neutrophils in paroxysmal cold haemoglobinuria.

Eur J Haematol 2012 Oct 2;89(4):371. Epub 2012 Aug 2.

Department of Laboratorial Haematology, Centro Hospitalar do Porto, Oporto, Portugal.

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http://dx.doi.org/10.1111/j.1600-0609.2012.01829.xDOI Listing
October 2012
14 Reads

A case study of a child with chronic hemolytic anemia due to a Donath-Landsteiner positive, IgM anti-I autoantibody.

Pediatr Blood Cancer 2012 Nov 2;59(5):953-5. Epub 2012 May 2.

Division of Transfusion Medicine, Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland, USA.

In children, paroxysmal cold hemoglobinuria (PCH) is generally considered an acute self-limited autoimmune hemolytic anemia caused by an IgG biphasic auto-anti-P antibody identified by the Donath-Landsteiner (D-L) test. We report a case of a 5-year-old female with a chronic hemolytic anemia. The etiology of the hemolysis appears to be an unusual D-L positive, IgM antibody with specificity for the I antigen. Read More

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http://dx.doi.org/10.1002/pbc.24185DOI Listing
November 2012
11 Reads

Drugs that inhibit complement.

Transfus Apher Sci 2012 Feb 13;46(1):87-92. Epub 2011 Dec 13.

German Red Cross Blood Transfusion Service Baden-Württemberg-Hessia, Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, and University of Ulm, Helmholtzstraße 10, 89081 Ulm, Germany.

The complement system is an important part of the innate immune system. Complement plays a crucial role in the pathophysiology of many disorders. Despite the pivotal role of the complement system, an approved targeted inhibitor of a complement factor became available only recently. Read More

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http://dx.doi.org/10.1016/j.transci.2011.11.012DOI Listing
February 2012
7 Reads

Erythrophagocytosis by neutrophils--a rare morphological phenomenon resulting in acquired haemolytic anaemia?

Int J Lab Hematol 2011 Aug 21;33(4):447-50. Epub 2011 Mar 21.

Department of Clinical Chemistry and Biochemistry, Medical University of Gdansk, Poland.

Erythrophagocytosis by neutrophils is a rare morphological phenomenon described in patients with clonal malignancies of haematopoiesis with myelodysplasia and in some haemolytic conditions including paroxysmal cold haemoglobinuria, haemolysis caused by snake-bite, sickle cell anaemia and other defects of red cells. We describe a female patient who presented with acquired haemolytic anaemia. Erythrophagocytosis was found in around 35% of neutrophils of the peripheral blood. Read More

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http://doi.wiley.com/10.1111/j.1751-553X.2011.01312.x
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http://dx.doi.org/10.1111/j.1751-553X.2011.01312.xDOI Listing
August 2011
19 Reads

Failure of eculizumab to correct paroxysmal cold hemoglobinuria.

Ann Hematol 2011 Aug 26;90(8):989-90. Epub 2010 Nov 26.

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http://dx.doi.org/10.1007/s00277-010-1123-xDOI Listing
August 2011
12 Reads

Recurrence of paroxysmal cold hemoglobinuria in a boy after physical cooling for fever.

J Pediatr Hematol Oncol 2011 Jan;33(1):40-2

Department of Pediatrics, Democritus University of Thrace and University General District Hospital of Alexandroupolis, Thrace, Greece.

Hemolysis and hemoglobinuria after direct exposure to cold has rarely been reported in paroxysmal cold hemoglobinuria (PCH). The authors describe a 2.5-year-old boy with PCH (Donath-Landsteiner autoimmune hemolytic anemia), in whom 16 days after presentation, the hemoglobinuria and hemolysis recurred, when he was subjected to physical cooling, as a means to control fever associated with hospital-acquired croup. Read More

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http://dx.doi.org/10.1097/MPH.0b013e3181f46e77DOI Listing
January 2011
9 Reads

A case of paroxysmal cold haemoglobinuria following chickenpox.

Ceylon Med J 2010 Sep;55(3):96

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September 2010
8 Reads

[Autoimmune hemolytic anemia].

Ther Umsch 2010 May;67(5):229-36

Klinik für Hämatologie, Departement Innere Medizin, UniversitätsSpital, Zürich.

Autoimmune hemolytic Anemia (AIHA) is a uncommon but potentially lethal disorder requiring prompt diagnosis and treatment. Diagnosis is based on clinical and laboratory signs of hemolysis and a positive direct antiglobulin test (DAT). AIHA is classified according to the clinical context (primary or secondary) and the characteristics of the auto-antibody (warm vs. Read More

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http://dx.doi.org/10.1024/0040-5930/a000042DOI Listing
May 2010
6 Reads