198,081 results match your criteria Hemoglobin [Journal]


Assessment of Exercise Capacity in Children with Type 1 Diabetes in the Cooper Running Test.

Int J Sports Med 2018 Dec 17. Epub 2018 Dec 17.

Department of Pediatrics, Diabetology, Endocrinology and Nephrology, Medical University of Lodz, Lodz, Poland.

Regular physical activity increases lifespan for those with type 1 diabetes. However, disease-related barriers may deter children from exercise and affect their fitness. This study examined the safety of the Cooper test concerning diabetes-related acute complications in children with type 1 diabetes and their fitness. Read More

View Article
December 2018
4 Reads

Effects of ALAD genotype on the relationship between lead exposure and anthropometry in a Cohort of Mexican children.

Environ Res 2018 Dec 5;170:65-72. Epub 2018 Dec 5.

Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, State University of New York at Buffalo, Buffalo, NY, USA. Electronic address:

Objectives: Lead exposure is associated with children's growth, but this relationship may depend on the presence of susceptibility factors, including genetic variation. Blood lead levels (BLL) differ by ALAD (aminolevulinic acid dehydratase) genotype. We investigated the association between BLL and growth in Mexican first-graders with different ALAD genotypes. Read More

View Article
December 2018

Household air pollution from biomass-burning cookstoves and metabolic syndrome, blood lipid concentrations, and waist circumference in Honduran women: A cross-sectional study.

Environ Res 2018 Dec 10;170:46-55. Epub 2018 Dec 10.

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA. Electronic address:

Background: Household air pollution from cooking with solid fuels affects nearly 3 billion people worldwide and is responsible for an estimated 2.5 million premature deaths and 77 million disability-adjusted life years annually. Investigating the effect of household air pollution on indicators of cardiometabolic disease, such as metabolic syndrome, can help clarify the pathways between this widespread exposure and cardiovascular diseases, which are increasing in low- and middle-income countries. Read More

View Article
December 2018

Long-Term Outcomes Among Patients Discharged From the Hospital With Moderate Anemia: A Retrospective Cohort Study.

Ann Intern Med 2018 Dec 18. Epub 2018 Dec 18.

Kaiser Permanente Northern California, Oakland, California (D.G.M., C.L., P.K., V.X.L., G.J.E.).

Background: Randomized clinical trial findings support decreased red blood cell (RBC) transfusion and short-term tolerance of in-hospital anemia. However, long-term outcomes related to changes in transfusion practice have not been described.

Objective: To describe the prevalence of anemia at and after hospital discharge and associated morbidity and mortality events. Read More

View Article
December 2018
1 Read

Empirically developed dietary inflammatory potential (EDIP) in patients candidate for coronary artery bypass grafting surgery (CABG): Association with metabolic parameters, dietary antioxidant quality score and dietary phytochemical index.

PLoS One 2018 17;13(12):e0208711. Epub 2018 Dec 17.

Department of Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

Aims: It has been suggested that empirically developed dietary inflammatory potential (EDIP) is a diagnostic tool for assessment of inflammatory potential of diet in prediction of risk factors related to chronic disease. In the current work, we examined the association between EDIP with cardio-metabolic risk factors, dietary antioxidant quality score (DAQs), dietary phytochemical index (DPI) and Mediterranean dietary quality index (MEDQI) in patients candidate for CABG.

Materials And Methods: In the current cross-sectional study, the data obtained from Tehran- Heart Center-Coronary Outcome Measurement (THC-COM) study from 454 patients candidate for the CABG were used. Read More

View Article
December 2018
1 Read

The sickle cell trait and end stage renal disease in Salvador, Brazil.

PLoS One 2018 17;13(12):e0209036. Epub 2018 Dec 17.

Instituto Gonçalo Moniz-FIOCRUZ-Bahia, Salvador, Brazil.

Background: Carriers of the sickle cell trait (HbAS) usually remain asymptomatic. However, under conditions of low tissue oxygenation, red blood cell sickling and vascular obstruction may develop. Chronic kidney disease (CKD) can arise from conditions promoting low-oxygen in kidney tissue, which may be aggravated by the presence of the sickle cell trait. Read More

View Article
December 2018
2 Reads

Effect of Endurance Training on Hemoglobin Mass and V˙O2max in Male Adolescent Athletes.

Med Sci Sports Exerc 2018 Dec 14. Epub 2018 Dec 14.

Section for Elite Sport, Swiss Federal Institute of Sport, Magglingen, Switzerland.

Purpose: It is unknown, whether endurance training stimulates hemoglobin mass (Hbmass) and V[Combining Dot Above]O2max increases during late adolescence. Therefore, this study assessed the influence of endurance training on Hbmass, blood volume parameters, and V[Combining Dot Above]O2max in endurance athletes and control subjects from age 16 to 19.

Methods: Hbmass, blood volume parameters, V[Combining Dot Above]O2max and anthropometric parameters were measured in male elite endurance athletes from age 16 to 19 in 6-month intervals (n=10), as well as in age-matched male controls (n=12). Read More

View Article
December 2018

Effective connectivity in subjects with mild cognitive impairment as assessed using functional near-infrared spectroscopy.

Am J Phys Med Rehabil 2018 Dec 14. Epub 2018 Dec 14.

Beijing Key Laboratory of Rehabilitation Technical Aids for Old-Age Disability, National Research Center for Rehabilitation Technical Aids, Beijing, 100176.

Objective: This study aimed to reveal the physiological mechanism in subjects with mild cognitive impairment (MCI) based on effective connectivity (EC) method.

Methods: EC was assessed by dynamic Bayesian inference (DBI) of the oxygenated hemoglobin concentration (Δ[HbO2]) signals measured through functional near-infrared spectroscopy (fNIRS). The Δ[HbO2] signals were recorded from the left prefrontal cortex (LPFC), right prefrontal cortex (RPFC), left motor cortex (LMC), right motor cortex (RMC), left occipital lobe (LOL) and right occipital lobe (ROL) of 26 subjects with MCI (MCI group) and 28 healthy elderly subjects (control group) at resting state. Read More

View Article
December 2018

Prospective associations between cardiac stress, glucose dysregulation and executive cognitive function in Black men: The Sympathetic activity and Ambulatory Blood Pressure in Africans study.

Diab Vasc Dis Res 2018 Dec 17:1479164118816221. Epub 2018 Dec 17.

1 Hypertension in Africa Research Team (HART) and School for Physiology, Nutrition and Consumer Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.

Objective:: Glucose dysregulation is an independent risk factor for cardiovascular and neurodegenerative disease development through synaptic dysfunction resulting in cognitive decline. The aim of this study was to study the interplay between impaired glycaemic metabolism (hyperglycaemia and insulin resistance), cardiac stress (cardiac troponin T and N-terminal brain natriuretic peptide) and executive cognitive function prospectively, in a bi-ethnic sex cohort.

Methods:: Black and White teachers (N = 338, aged 20-63 years) from the Sympathetic activity and Ambulatory Blood Pressure in Africans study were monitored over a 3-year period. Read More

View Article
December 2018

Short-acting insulin analogues versus regular human insulin for adult, non-pregnant persons with type 2 diabetes mellitus.

Cochrane Database Syst Rev 2018 Dec 17;12:CD013228. Epub 2018 Dec 17.

Institute of General Practice, Goethe University, Theodor-Stern-Kai 7, Frankfurt am Main, Hesse, Germany, 60590.

Background: The use of short-acting insulin analogues (insulin lispro, insulin aspart, insulin glulisine) for adult, non-pregnant people with type 2 diabetes is still controversial, as reflected in many scientific debates.

Objectives: To assess the effects of short-acting insulin analogues compared to regular human insulin in adult, non-pregnant people with type 2 diabetes mellitus.

Search Methods: For this update we searched CENTRAL, MEDLINE, Embase, the WHO ICTRP Search Portal, and ClinicalTrials. Read More

View Article
December 2018

For Debate: Paediatric T1DM: DKA is Still a Problem.

Pediatr Endocrinol Rev 2018 Dec;16(2):233-239

Hospital Universitario de Cruces, CIBERDEM, CIBERER, BIOCRUCES, Plaza Cruces s/n, 48903 Bizkaia, Spain, E-mail:

Although the treatment of pediatric patients with T1DM has improved ketoacidosis (DKA) remains a frequent problem.

Objective: To estimate temporal changes in the prevalence of DKA at diagnosis of T1DM and to explore the factors associated with its occurrence.

Methods: Paediatric patients diagnosed at Cruces University Hospital (Spain) since 1997 were included. Read More

View Article
December 2018

Helicobacter pylori eradication improves glycemic control in type 2 diabetic patients with asymptomatic active Helicobacter pylori infection.

J Diabetes Investig 2018 Dec 16. Epub 2018 Dec 16.

Division of Endocrinology and Metabolism, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Aims/introduction: Helicobacter pylori infection is associated with insulin resistance and glycemia in nondiabetes. However, the relationship between Helicobacter pylori infection and glycemia in diabetes remains inconclusive. Therefore, we explored the effect of Helicobacter pylori infection status and its eradication on glycemic control and antidiabetic therapy in type 2 diabetes. Read More

View Article
December 2018

Diabetic Ketoacidosis at Diagnosis of Type 1 Diabetes and Glycemic Control over Time: The SEARCH for Diabetes in Youth Study.

Pediatr Diabetes 2018 Dec 17. Epub 2018 Dec 17.

Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Background: The diagnosis of type 1 diabetes (T1D) in youth is often associated with diabetic ketoacidosis (DKA). We aimed to evaluate if the presence of DKA at diagnosis of T1D is associated with less favorable hemoglobin A (HbA1c) trajectories over time.

Methods: The SEARCH for Diabetes in Youth study of 1396 youth aged <20 years with newly diagnosed T1D were followed for up to 13 [median 8 (IQR 6-9)] years post-diagnosis. Read More

View Article
December 2018

Engineered zinc-finger nuclease to generate site-directed modification in the KLF1 gene for fetal hemoglobin induction.

J Cell Biochem 2018 Dec 16. Epub 2018 Dec 16.

Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Elevation of hemoglobin F (HbF) ameliorates symptoms of β-thalassemia, as a common autosomal recessive disorder. In this study, the ability of an engineered zinc-finger nuclease (ZFN) system was assesed to disrupt the KLF1 gene to inhibit the γ to β hemoglobin switching in K562 cells. This study was performed using a second generation integration-deficient lentiviral vector assigned to transient gene targeting. Read More

View Article
December 2018

Cerebral fat embolism syndrome in sickle cell disease without evidence of shunt.

eNeurologicalSci 2019 Mar 22;14:19-20. Epub 2018 Nov 22.

Pennsylvania Hospital, 800 Spruce Street, Philadelphia, PA 19107, USA.

Fat embolism syndrome (FES) is a known complication of sickle cell disease (SCD) that occurs secondary to vaso-occlusive crises, bone marrow infarction, and the subsequent release of fat globules into the venous circulation. Although neurologic involvement is common, the pathophysiology of cerebral fat emboli remains controversial. While fat microemboli can enter the arterial circulation through right-to-left shunts, the systemic release of free fatty acids may also cause indirect endothelial damage and disruption of the blood-brain-barrier. Read More

View Article
March 2019
1 Read

Proteomic Analysis of Hemocytes During Encapsulation of Sporocysts.

Front Immunol 2018 29;9:2773. Epub 2018 Nov 29.

Department of Pathobiological Sciences, University of Wisconsin, Madison, WI, United States.

Circulating hemocytes of the snail , a major intermediate host for the blood fluke , represent the primary immune effector cells comprising the host's internal defense system. Within hours of miracidial entry into resistant strains, hemocytes infiltrate around developing sporocysts forming multi-layered cellular capsules that results in larval death, typically within 24-48 h post-infection. Using an model of hemocyte-sporocyst encapsulation that recapitulates events, we conducted a comparative proteomic analysis on the responses of hemocytes from inbred strains during the encapsulation of primary sporocysts. Read More

View Article
November 2018

Early Detection of Hemodynamic Responses Using EEG: A Hybrid EEG-fNIRS Study.

Front Hum Neurosci 2018 29;12:479. Epub 2018 Nov 29.

School of Mechanical Engineering, Pusan National University, Busan, South Korea.

Enhanced classification accuracy and a sufficient number of commands are highly demanding in brain computer interfaces (BCIs). For a successful BCI, early detection of brain commands in time is essential. In this paper, we propose a novel classifier using a modified vector phase diagram and the power of electroencephalography (EEG) signal for early prediction of hemodynamic responses. Read More

View Article
November 2018

Impact of inflammatory markers on survival in patients with limited disease small-cell lung cancer undergoing chemoradiotherapy.

Cancer Manag Res 2018 30;10:6563-6569. Epub 2018 Nov 30.

Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany,

Background: Systemic inflammation appears to play a role in the progression of numerous solid tumors by promoting tumor proliferation. Our current study aimed to evaluate the role of inflammatory markers in limited disease (LD) small-cell lung cancer (SCLC) patients undergoing thoracic chemoradiotherapy (TCR).

Patients And Methods: We retrospectively analyzed a total number of 350 SCLC patients diagnosed with LD SCLC who received TCR between 1999 and 2017 and had available blood tests within 2 weeks prior to the start of TCR. Read More

View Article
November 2018

Glycated Hemoglobin Level Goal Achievement in Adults With Type 2 Diabetes in Canada: Still Room for Improvement.

Can J Diabetes 2018 Nov 2. Epub 2018 Nov 2.

Li Ka Shing Knowledge Institute of St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Canadian Heart Research Centre, Toronto, Ontario, Canada.

Objectives: To describe the clinical histories and management of adults with type 2 diabetes who were not reaching their target glycated hemoglobin (A1C) levels and to identify barriers to achieving therapeutic goals.

Methods: Practice assessment surveys and practice audits were completed by 88 primary care physicians (PCPs) in the Diabetes Mellitus Assessment of Clinical managemenT In ONtario (DM-ACTION) program and by 56 diabetes specialists in the Diabetes Mellitus IMproving PAtient Care in our communiTies (DM-IMPACT) program. The DM-ACTION audit analyzed data from 1,173 adults with A1C levels ≥7. Read More

View Article
November 2018

SOX7 methylation is an independent prognostic factor in myelodysplastic syndromes.

Pathol Res Pract 2018 Dec 6. Epub 2018 Dec 6.

Laboratory Center, Affiliated People's Hospital of Jiangsu University, Zhenjiang 212002, Jiangsu, PR China; Zhenjiang Clinical Research Center of Hematology, Zhenjiang 212002, Jiangsu, P.R. China; The Key Lab of Precision Diagnosis and Treatment in Hematologic Malignancies of Zhenjiang City, Zhenjiang 212002, Jiangsu, P.R. China. Electronic address:

Objective: SOX7 downregulation caused by its promoter methylation was associated with poor survival in several types of human solid tumors. However, the pattern of SOX7 methylation and its clinical significance are less studied in hematological malignancies. Herein, we evaluated the methylation pattern of SOX7 in myelodysplastic syndrome (MDS) and determined its clinical implication in patients with MDS. Read More

View Article
December 2018
1 Read

Independent and combined effects of improved water, sanitation, and hygiene, and improved complementary feeding, on child stunting and anaemia in rural Zimbabwe: a cluster-randomised trial.

Lancet Glob Health 2019 Jan;7(1):e132-e147

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore MD, USA; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe; Blizard Institute, Queen Mary University of London, London, UK.

Background: Child stunting reduces survival and impairs neurodevelopment. We tested the independent and combined effects of improved water, sanitation, and hygiene (WASH), and improved infant and young child feeding (IYCF) on stunting and anaemia in in Zimbabwe.

Methods: We did a cluster-randomised, community-based, 2 × 2 factorial trial in two rural districts in Zimbabwe. Read More

View Article
January 2019

A hit deconstruction approach for the discovery of fetal hemoglobin inducers.

Bioorg Med Chem Lett 2018 Dec 22;28(23-24):3676-3680. Epub 2018 Oct 22.

GlaxoSmithKline, 1250 South Collegeville Rd., Collegeville, PA 19426, USA.

Beta-hemoglobinopathies such as sickle cell disease represent a major global unmet medical need. De-repression of fetal hemoglobin in erythrocytes is a clinically validated approach for the management of sickle cell disease, but the only FDA-approved medicine for this purpose has limitations to its use. We conducted a phenotypic screen in human erythroid progenitor cells to identify molecules with the ability to de-repress fetal hemoglobin, which resulted in the identification of the benzoxaborole-containing hit compound 1. Read More

View Article
December 2018

Maternal anaemia and maternal, foetal and neonatal outcomes in a prospective cohort study in India and Pakistan.

BJOG 2018 Dec 16. Epub 2018 Dec 16.

Thomas Jefferson University, 130 S 9th St, Philadelphia, PA, 19107, USA.

Objective: To describe the association of maternal anaemia with maternal, foetal and neonatal outcomes.

Design: Prospective cohort study.

Setting: Rural India and Pakistan. Read More

View Article
December 2018

Prognostic models for predicting overall survival in metastatic castration-resistant prostate cancer: a systematic review.

World J Urol 2018 Dec 15. Epub 2018 Dec 15.

UroEvidence@Deutsche Gesellschaft für Urologie, Berlin, Germany.

Purpose: Prognostic models are developed to estimate the probability of the occurrence of future outcomes incorporating multiple variables. We aimed to identify and summarize existing multivariable prognostic models developed for predicting overall survival in patients with metastatic castration-resistant prostate cancer (mCRPC).

Methods: The protocol was prospectively registered (CRD42017064448). Read More

View Article
December 2018
1 Read

Correlations of Acute Cerebral Hemorrhage Complicated with Stress Ulcer Bleeding with Acute Physiology and Chronic Health Evaluation (APACHE) II Score, Endothelin (ET), Tumor Necrosis Factor-alpha (TNF-α), and Blood Lipids.

Med Sci Monit 2018 Dec 16;24:9120-9126. Epub 2018 Dec 16.

Department of Gastroenterology, Tai'an Central Hospital, Tai'an, Shandong, China (mainland).

BACKGROUND This study investigated the correlations between acute cerebral hemorrhage complicated with stress ulcer bleeding and corresponding indexes, including the Acute Physiology and Chronic Health Evaluation (APACHE) II score, vascular endothelin-1 (ET-1), tumor necrosis factor-alpha (TNF-α), and blood lipid factors. MATERIAL AND METHODS A total of 53 patients with acute cerebral hemorrhage complicated with stress ulcer bleeding were selected as the observation group and 50 patients with simple acute cerebral hemorrhage were selected as the control group. The APACHE II score and the levels of ET-1, TNF-α, and blood lipid factors, including total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and malondialdehyde (MDA), were detected and the correlations of were analyzed between the 2 groups of patients. Read More

View Article
December 2018

Metformin Affects Heme Function as a Possible Mechanism of Action.

G3 (Bethesda) 2018 Dec 15. Epub 2018 Dec 15.

Stanford University

Metformin elicits pleiotropic effects that are beneficial for treating diabetes, and as well as particular cancers and aging. In spite of its importance, a convincing and unifying mechanism to explain how metformin operates is lacking. Here we describe investigations into the mechanism of metformin action through heme and hemoprotein(s). Read More

View Article
December 2018
1 Read

Bioaccumulation and morphological traits in a multi-generation test with two Daphnia species exposed to lead.

Chemosphere 2018 Dec 7;219:636-644. Epub 2018 Dec 7.

Department of Biology & CESAM, University of Aveiro, 3810-193, Portugal.

Anthropic pressure negatively affects natural environments. Lead (Pb) is a non-essential highly toxic metal that is present in aquatic ecosystems. Two daphnid species from two different latitudes, the temperate Daphnia magna and the tropical Daphnia similis were used as test-organisms to evaluate a long-term Pb exposure. Read More

View Article
December 2018

Reduction of stool bacterial counts and prevention of diarrhea using an oral homeopathic product in newborn lambs.

Microb Pathog 2018 Dec 13. Epub 2018 Dec 13.

Department of Animal Science, Universidade do Estado de Santa Catarina (UDESC), Brazil; Graduate Program in Animal Science, UDESC, Brazil. Electronic address:

Lamb farming is generally a secondary activity for farmers, and many breeding systems suffer from management failures that impair production. One reason for decline in performance is enteritis, usually affecting newborn lambs. Enteritis can be fatal, especially in dairy herds. Read More

View Article
December 2018
1 Read

Incidence, Predictors, and Outcome Associations of Dyskalemia in Heart Failure With Preserved, Mid-Range, and Reduced Ejection Fraction.

JACC Heart Fail 2018 Dec 10. Epub 2018 Dec 10.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Objectives: This study investigated 1-year incidence and predictors of dyskalemia (dysK) and its outcome associations in heart failure with preserved ejection fraction (HFpEF), HF with mid-range EF (HFmrEF), and HF with reduced EF (HFrEF).

Background: DysK in real-world HF is insufficiently characterized. Fear of dyskalemia may lead to underuse or underdosing of renin-angiotensin-aldosterone system inhibitors. Read More

View Article
December 2018

Transcatheter aortic valve replacement outcomes in Japan: Optimized CathEter vAlvular iNtervention (OCEAN) Japanese multicenter registry.

Cardiovasc Revasc Med 2018 Dec 4. Epub 2018 Dec 4.

Department of cardiology, Keio University School of Medicine, Tokyo, Japan.

Objectives: We aimed to assess real-world clinical outcomes of transcatheter aortic valve replacement (TAVR) in Japan.

Background: Data are limited concerning procedural safety and valve performance following TAVR in Japanese. A program by an on-site proctor and procedure screening system was applied during TAVR introduction. Read More

View Article
December 2018

[Hemodialysis performance in Center East Tunisia: Compliance and adequacy of biological tests (PHCET study 2014)].

Rev Epidemiol Sante Publique 2018 Dec 12. Epub 2018 Dec 12.

Unité de recherche « Mesure de performance hospitalière : UR12 SP36 », Direction des systèmes d'information, CHU Sahloul, Sousse, Tunisie.

Background: Determining the performance level of hemodialysis facilities, including an evaluation of biological tests, is a prerequisite for quality assessment of these healthcare structures.

Objective: The purpose of this work was to evaluate the compliance and adequacy of biological tests performed in 2014 in Center-East Tunisia hemodialysis units.

Methods: Data were collected using an analysis grid for 15 biological indicators including 11 process items and four results items used to determine the compliance and adequacy rates respectively. Read More

View Article
December 2018

Glycated Hemoglobin and Outcomes of Heart Failure (from Get With the Guidelines-Heart Failure).

Am J Cardiol 2018 Dec 3. Epub 2018 Dec 3.

Division of Cardiology, Ahmanson-UCLA Cardiomyopathy Center, University of California, Los Angeles, California. Electronic address:

Glycated hemoglobin (HbA) is a risk factor for new onset heart failure (HF). There is however a paucity of data evaluating its association with outcomes in patients with established HF. We assessed the relation of HbA with outcomes among hospitalized HF patients. Read More

View Article
December 2018

Efficacy and safety of partial splenic embolization for hypersplenism in pre- and post-liver transplant patients: A 16-year comparative analysis.

Clin Imaging 2018 Nov 27;54:71-77. Epub 2018 Nov 27.

Department of Radiology, Division of Vascular and Interventional Radiology, Columbia University Medical Center, 177 Fort Washington Ave, Milstein Hospital - 4 Hudson North, New York, NY 10032, United States of America.

Purpose: To report the effect of partial splenic embolization (PSE) on hematological indices and the procedure's safety in pre- and post-liver transplant (LT) patients.

Materials And Methods: A single-center retrospective study evaluating all patients who underwent PSE over a 16-year period was performed. Inclusion criteria were splenomegaly confirmed by imaging and at least one of the following cytopenias: hemoglobin ≤10 g/dL, WBC count ≤1500 μL, or platelet count ≤100,000 μL. Read More

View Article
November 2018
2 Reads

Exercise and insulin resistance in type 2 diabetes mellitus: A systematic review and meta-analysis.

Ann Phys Rehabil Med 2018 Dec 13. Epub 2018 Dec 13.

576104 Manipal, Karnataka, India. Electronic address:

Background: Insulin resistance is a determining factor in the pathophysiology of type 2 diabetes mellitus (T2DM). Exercise is known to improve insulin resistance, but a systematic review of the literature is lacking.

Objective: This systematic review and meta-analysis focused on identifying evidence for the effectiveness of a structured exercise intervention program for insulin resistance in T2DM. Read More

View Article
December 2018
3 Reads

Comparison of fatigue, pain and depression in patients with advanced kidney disease and cancer - symptom burden and clusters.

J Pain Symptom Manage 2018 Dec 12. Epub 2018 Dec 12.

Department of Surgery, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA.

Context: While symptom clusters have been studied in the context of cancer, few data exist in chronic and end stage kidney disease (CKD/ESKD) patients.

Objectives: To (1) characterize and compare symptom cluster phenotypes in patients with advanced CKD, ESKD and cancer, and (2) explore predictors of symptom clusters.

Methods: We conducted secondary data analysis of three prospective studies in which pain, depression, and fatigue were assessed in patients with stage 4-5 CKD, ESKD and gastrointestinal (GI) cancer. Read More

View Article
December 2018

Effects of proton pump inhibitors on severe haematotoxicity induced after first course of pemetrexed/carboplatin combination chemotherapy.

J Clin Pharm Ther 2018 Dec 15. Epub 2018 Dec 15.

Laboratory of Applied Therapeutics, Center for Education & Research on Clinical Pharmacy, Showa Pharmaceutical University, Tokyo, Japan.

What Is Known And Objective: Pemetrexed/carboplatin combination chemotherapy has shown efficacy as a first-line treatment for advanced non-small-cell lung cancer. However, severe haematotoxicity is often observed during this combination chemotherapy. Some studies have suggested that concomitant drugs may be the risk factors for severe adverse events. Read More

View Article
December 2018
1 Read

Comparative effectiveness and harms of long-acting insulins for Type 1 and Type 2 diabetes: a systematic review and meta-analysis.

Diabetes Obes Metab 2018 Dec 15. Epub 2018 Dec 15.

Pacific Northwest Evidence-based Practice Center Oregon Health & Science University, Portland, Oregon.

Aims: To review evidence comparing benefits and harms of long-acting insulins in Type 1 and 2 diabetes.

Methods: MEDLINE and two Cochrane databases were searched through February 2018. Two authors selected studies meeting inclusion criteria and assessed their quality. Read More

View Article
December 2018

No overlap between IgG4-related disease and microscopic polyangiitis and granulomatosis with polyangiitis despite elevated serum IgG4 at diagnosis: a retrospective monocentric study.

Clin Rheumatol 2018 Dec 14. Epub 2018 Dec 14.

Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.

Objectives: We investigated whether elevated serum IgG4 at the time of diagnosis of microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) may be associated with concurrent IgG4-related disease (IgG4-RD) in immunosuppressive drug-naïve patients.

Methods: We retrospectively reviewed the medical records of 46 MPA and GPA patients with results on serum IgG4 and histology at diagnosis. Elevated serum IgG4 was defined as IgG4 > 135 mg/dL. Read More

View Article
December 2018

Out-of-home informal support important for medication adherence, diabetes distress, hemoglobin A1c among adults with type 2 diabetes.

J Behav Med 2018 Dec 14. Epub 2018 Dec 14.

Department of Family Medicine, University of Michigan, Ann Arbor, MI, USA.

Adults with type 2 diabetes mellitus (T2DM) often receive self-management support from adult children, siblings or close friends residing outside of their home. However, the role of out-of-home support in patients' self-management and well-being is unclear. Patients (N = 313) with HbA1c > 7. Read More

View Article
December 2018
1 Read

Spasticity and preservation of skeletal muscle mass in people with spinal cord injury.

Spinal Cord 2018 Dec 14. Epub 2018 Dec 14.

Department of Rehabilitation Medicine, College of Medicine, Seoul National University, Seoul, Korea.

Study Design: Cross-sectional OBJECTIVE: To investigate the association between skeletal muscle mass and spasticity in people with spinal cord injury (SCI).

Setting: Tertiary level hospital in Seoul, Korea METHODS: Spasticity was evaluated in 69 participants with SCI using the spasticity sum score (SSS), Penn Spasm Frequency Scale (PSFS), and Spinal Cord Assessment Tool for Spastic Reflexes (SCATS). Skeletal muscle mass was measured using a dual-energy X-ray absorptiometry scanner, and skeletal muscle index was calculated by dividing skeletal muscle mass by height squared. Read More

View Article
December 2018

Supported self-management for people with type 2 diabetes: a meta-review of quantitative systematic reviews.

BMJ Open 2018 Dec 14;8(12):e024262. Epub 2018 Dec 14.

Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK.

Objectives: Self-management support aims to give people with chronic disease confidence to actively manage their disease, in partnership with their healthcare provider. A meta-review can inform policy-makers and healthcare managers about the effectiveness of self-management support strategies for people with type 2 diabetes, and which interventions work best and for whom.

Design: A meta-review of systematic reviews of randomised controlled trials (RCTs) was performed adapting Cochrane methodology. Read More

View Article
December 2018
1 Read

Informed shared decision-making programme for patients with type 2 diabetes in primary care: cluster randomised controlled trial.

BMJ Open 2018 Dec 14;8(12):e024004. Epub 2018 Dec 14.

Health Sciences and Education, University of Hamburg, Hamburg, Germany.

Objective: To translate an informed shared decision-making programme (ISDM-P) for patients with type 2 diabetes from a specialised diabetes centre to the primary care setting.

Design: Patient-blinded, two-arm multicentre, cluster randomised controlled trial of 6 months follow-up; concealed randomisation of practices after patient recruitment and acquisition of baseline data.

Setting: 22 general practices providing care according to the German Disease Management Programme (DMP) for type 2 diabetes. Read More

View Article
December 2018

Indigenous health worker support for patients with poorly controlled type 2 diabetes: study protocol for a cluster randomised controlled trial of the Mana Tū programme.

BMJ Open 2018 Dec 14;8(12):e019572. Epub 2018 Dec 14.

Te Kupenga Hauora Māori, University of Auckland, Auckland, New Zealand.

Introduction: Type 2 diabetes mellitus (T2DM) and its complications are more common among Māori and Pacific people compared with other ethnic groups in New Zealand. Comprehensive and sustained approaches that address social determinants of health are required to address this condition, including culturally specific interventions. Currently, New Zealand has no comprehensive T2DM management programme for Māori or Pacific people. Read More

View Article
December 2018

Oral mucosa pressure ulcers in intensive care unit patients: A preliminary observational study of incidence and risk factors.

J Tissue Viability 2018 Dec 5. Epub 2018 Dec 5.

Urology Ward, Pusan National University Hospital, Busan, South Korea.

Purpose: This study examined the incidence of oral mucosa pressure ulcers (PUs) in intensive care unit (ICU) patients and the relationship between biomechanical and physiological variables in onset of PUs.

Methods: A prospective observational descriptive study design was used. We recruited patients over 18 years of age with endotracheal tube (ETT) insertion in three ICUs in a tertiary hospital in Korea. Read More

View Article
December 2018
1 Read

Effects of lycopene on metabolism of glycolipid in type 2 diabetic rats.

Biomed Pharmacother 2019 Jan 26;109:2070-2077. Epub 2018 Nov 26.

Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, China. Electronic address:

Diabetes is a series of metabolic diseases, which characteristics is hyperglycemia caused by the interruption of insulin action. Lycopene is an antioxidant which has potential anti-diabetic activity but the correlative reports are rare. This study was designed to explore the influence of lycopene on metabolism of glycolipid in type 2 diabetes. Read More

View Article
January 2019

A novel rutin-fucoidan complex based phytotherapy for cervical cancer through achieving enhanced bioavailability and cancer cell apoptosis.

Biomed Pharmacother 2019 Jan 6;109:1181-1195. Epub 2018 Nov 6.

Laboratory of Aquabiotics/Nanoscience, Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, India. Electronic address:

Recent studies on flavonoids forming complexes with macromolecules attract researchers due to their enhanced bioavailability as well as chemo-preventive efficacy. In this study, a flavonoid rutin (Ru) is non-covalently complexed with fucoidan (Fu) using the functional groups to obtain a therapeutic polymeric complex overcoming the limitations of bioavailability of rutin. The prepared novel rutin-fucoidan (Ru-Fu) complex is characterized for spectroscopic features, particle size and distribution analysis by DLS. Read More

View Article
January 2019

Cardiovascular and Metabolic Risk in Women in the First Year Postpartum: Allostatic Load as a Function of Race, Ethnicity, and Poverty Status.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Internal Medicine, UCLA Geffen School of Medicine, Los Angeles, California.

Objective:  Allostatic load (AL) represents multisystem physiological "wear-and-tear" reflecting emerging chronic disease risk. We assessed AL during the first year postpartum in a diverse community sample with known health disparities.

Methods:  The Shriver National Institute for Child Health and Human Development Community Child Health Network enrolled 2,448 predominantly low-income African-American, Latina, and White women immediately after delivery of liveborn infants at ≥20 weeks' gestation, following them over time with interviews, clinical measures, and biomarkers. Read More

View Article
December 2018
1 Read

Prevalence and correlates of anemia among adolescents in Nepal: Findings from a nationally representative cross-sectional survey.

PLoS One 2018 14;13(12):e0208878. Epub 2018 Dec 14.

Department of Paediatrics, the University of Melbourne, Melbourne, Australia.

Anemia is regarded as major public health problem among adolescents in Low and Middle-Income Countries (LMICs) but there is limited primary data in many countries, including Nepal. This study investigated the prevalence and correlates of anemia in a nationally representative sample of adolescents within the 2014 National Adolescent Nutrition Survey in Nepal. A total of 3780 adolescents aged 10 to 19 years were selected from a cross-sectional survey through multi-stage cluster sampling. Read More

View Article
December 2018
1 Read

Iron-associated protein interaction networks reveal the key functional modules related to survival and virulence of Pasteurella multocida.

Microb Pathog 2018 Dec 11;127:257-266. Epub 2018 Dec 11.

Department of Zoology, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand; Omics Center for Agriculture, Bioresources, Food, and Health, Faculty of Science, Kasetsart University (OmiKU), Bangkok, 10900, Thailand. Electronic address:

Pasteurella multocida causes respiratory infectious diseases in a multitude of birds and mammals. A number of virulence-associated genes were reported across different strains of P. multocida, including those involved in the iron transport and metabolism. Read More

View Article
December 2018