Biochim Biophys Acta Mol Basis Dis 2021 Apr 9;1867(7):166142. Epub 2021 Apr 9.
Faculty of Medicine, The University of Queensland, Brisbane, Australia; Gallipoli Medical Research Institute, Greenslopes Private Hospital, Brisbane, Australia; The QIMR Berghofer Medical Research Institute, Brisbane, Australia; Hepatogenomics Research Group, School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane, Australia. Electronic address:
Background & Aims: Iron has been proposed as influencing the progression of liver disease in subjects with non-alcoholic fatty liver disease (NAFLD). We have previously shown that, in the Hfe mouse model of hemochromatosis, feeding of a high-calorie diet (HCD) leads to increased liver injury. In this study we investigated whether the feeding of an iron deficient/HCD to Hfe mice influenced the development of NAFLD. Read More