- Tomas Ganz
Int J Hematol 2017 Nov 16. Epub 2017 Nov 16.
CHS 52-243, Departments of Medicine and Pathology, David Geffen School of Medicine, University of California, 10833 Le Conte Ave., Los Angeles, CA, 90095, USA.
Iron is an essential trace metal for nearly all infectious microorganisms, and host defense mechanisms target this dependence to deprive microbes of iron. This review highlights mechanisms that are activated during infections to restrict iron on mucosal surfaces, in plasma and extracellular fluid, and within macrophages. Iron overload disorders, such as hereditary hemochromatosis or β-thalassemia, interfere with iron-restrictive host responses, and thereby cause increased susceptibility to infections with microbes that can exploit this vulnerability. Read More