41,894 results match your criteria Hematological Oncology[Journal]


Non-GVHD ocular complications after hematopoietic cell transplantation: expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT.

Biol Blood Marrow Transplant 2018 Dec 3. Epub 2018 Dec 3.

Department of Ophthalmology, Hospital Universitario Puerta de Hierro, Madrid, Spain.

Non-graft-versus-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Complications discussed in this review include cataracts, glaucoma, ocular infections, ocular involvement with malignancy, ischemic microvascular retinopathy, central retinal vein occlusion, retinal hemorrhage, retinal detachment and ocular toxicities associated with medications. Read More

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December 2018
5 Reads

Polysaccharide from a Tunisian red seaweed Chondrus canaliculatus: Structural characteristics, antioxidant activity and in vivo hemato-nephroprotective properties on maneb induced toxicity.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Laboratory of Enzyme engineering and Microbiology, National Engineering School in Sfax, University of Sfax, B.P. 1173, 3038 Sfax, Tunisia. Electronic address:

The present study aims to investigate the physicochemical and the structural features of polysaccharide isolated from the red marine macro alga Chondrus canaliculatus (C.C.P) using FT-IR, gel filtration high-pressure chromatograph, HPLC-FID and solid state C NMR analysis. Read More

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December 2018

Hematological evaluation of free-living golden-headed lion tamarins (Leontopithecus chrysomelas) from an Urban Atlantic Forest.

J Med Primatol 2018 Dec 6. Epub 2018 Dec 6.

Departamento de Patologia e Clínica Veterinária, Universidade Federal Fluminense, Niteroi, RJ, Brazil.

Background: The Atlantic Forest where the animals were captured is surrounded by residences, so this close contact could favor the presence of disease-transmitting pathogens, putting the local population at risk. For these and other factors, it is important to perform laboratory tests enabling the performance of important diagnoses.

Methods: Blood samples of 268 golden-headed lion tamarins (Leontopithecus chrysomelas) inhabiting an Atlantic Forest area in Rio de Janeiro, Brazil, were processed for accessing age and sex influence in hematological parameters and to establish normative hematology values. Read More

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December 2018
1 Read

Association between serum 25(OH)D and hematological markers of erythropoiesis: the curse of large numbers, the treachery of p value.

Eur J Pediatr 2018 Dec 5. Epub 2018 Dec 5.

Epidemiology and Statistics Office, Research Unit, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.

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December 2018
1 Read

Vascular density and inflammatory infiltrate in primary oral squamous cell carcinoma and after allogeneic hematopoietic stem cell transplantation.

Ann Hematol 2018 Dec 5. Epub 2018 Dec 5.

Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Piazza Giulio Cesare, 11, 70124, Bari, Italy.

Hematopoietic stem cell transplantation (HSCT) recipients have been reported to have an increased risk of chronic graft versus host disease (cGVHD) and hematological and solid cancers. Oral manifestations are the first signs of cGVHD observed in the majority of patients, and oropharyngeal cancer is the most frequent secondary malignancy occurred after HSCT. In this study, we have evaluated the inflammatory infiltrate cell content and correlated with the vascular density in patients affected by primary oral squamous cell carcinoma (OSCC) from previous healthy controls and OSCC after cGVHD. Read More

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December 2018
1 Read

Pernicious Anemia Presented with Isolated Nominal Dysphasia in Type Ill Polyglandular Failure Female Patient.

Cureus 2018 Sep 14;10(9):e3306. Epub 2018 Sep 14.

Medicine, Xavier University School of Medicine, Oranjestad, ABW.

Pernicious anemia (also known as Biermer's disease) is an autoimmune atrophic gastritis which predominantly affects the fundus of the stomach. It results in a deficiency of vitamin B12 (cobalamin) as it affects the normal process of absorption in the ileum. The pernicious anemia is characterized by a wide range of hematological and neurological features. Read More

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September 2018

The Efficacy and Safety of Anti-epidermal Growth Factor Receptor Monoclonal Antibodies in Nasopharyngeal Carcinoma: Literature-based Meta-analyses.

J Cancer 2018 31;9(23):4510-4520. Epub 2018 Oct 31.

Department of Radiation Oncology, Sun Yat-sen University Cancer Centre; State Key Laboratory of Oncology in South China; Collaborative Innovation Centre of Cancer Medicine; Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China.

Anti-epidermal growth factor receptor monoclonal antibodies (anti-EGFR mAbs), such as cetuximab and nimotuzumab have been used in the treatment of nasopharyngeal carcinoma (NPC), yet their efficacy and safety are undetermined. : We performed two meta-analyses based on systematic searches of PubMed, EMBASE, the Cochrane Library and SinoMed: comparison 1 (standard therapy plus mAbs vs. standard therapy) and comparison 2 (radiotherapy plus concurrent mAbs vs. Read More

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October 2018
1 Read

Detection of Exon 12 and 14 Mutations in Janus Kinase 2 Gene Including a Novel Mutant in V617F Negative Polycythemia Vera Patients from Pakistan.

J Cancer 2018 21;9(23):4341-4345. Epub 2018 Oct 21.

Cancer and Medical Genetics, CAMS-A, King Saud Bin Abdulaziz University for Health Sciences & King Abdullah International Medical Research Centre (KAIMRC), King Abdulaziz Medical City, National Guard Health Affairs, Al Ahsa, Saudi Arabia.

The most frequently reported genetic aberration among polycythemia vera (PV) patients is a gain of function mutation V617F in exon 14 of Janus kinase 2 (JAK2) gene. However in many investigations, V617F negative PV patients have been reported to harbor mutations in JAK 2 exon 12. We investigated 24 patients with PV (diagnosed following 2016 WHO guidelines) to detect V617F mutation through allele specific PCR. Read More

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October 2018
2 Reads

ABPS: An R Package for Calculating the Abnormal Blood Profile Score.

Front Physiol 2018 21;9:1638. Epub 2018 Nov 21.

Bioinformatics Core Facility, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.

The Abnormal Blood Profile Score (ABPS) is used to identify blood doping in sport. It combines seven hematological markers, including hemoglobin level, reticulocytes percent, and haematocrit level, using two different machine learning algorithms in order to create a single score that has a better ability to identify doping than each parameter taken alone. The resulting score allows the detection of several types of doping using a single score and is part of the current Athlete Biological Passport program managed by World Anti-Doping Agency (WADA). Read More

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November 2018
2 Reads

Iron Dysregulation and Dormant Microbes as Causative Agents for Impaired Blood Rheology and Pathological Clotting in Alzheimer's Type Dementia.

Front Neurosci 2018 16;12:851. Epub 2018 Nov 16.

Department of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa.

Alzheimer's disease and other similar dementias are debilitating neurodegenerative disorders whose etiology and pathogenesis remain largely unknown, even after decades of research. With the anticipated increase in prevalence of Alzheimer's type dementias among the more susceptible aging population, the need for disease-modifying treatments is urgent. While various hypotheses have been put forward over the last few decades, we suggest that Alzheimer's type dementias are triggered by external environmental factors, co-expressing in individuals with specific genetic susceptibilities. Read More

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November 2018
2 Reads

Treatment of Epstein-Barr virus associated central nervous system diseases after allogeneic hematopoietic stem cell transplantation with intrathecal donor lymphocyte infusion.

Bone Marrow Transplant 2018 Dec 5. Epub 2018 Dec 5.

Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, 450008, Zhengzhou, China.

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective measure for the treatment of hematological disease. With the progress and widespread use of allo-HSCT, Epstein-Barr virus (EBV) related central nervous system (CNS) diseases have gotten more and more attention because of its poor prognosis and overall survival. Since currently there is no standard treatment for patients with EBV-associated CNS diseases and reported therapies are heterogeneous with mixed results, we attempted to develop a novel therapeutic method. Read More

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December 2018
2 Reads

The Role of Glucocorticoid Receptor Signaling in Bladder Cancer Progression.

Cancers (Basel) 2018 Dec 4;10(12). Epub 2018 Dec 4.

Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA.

Previous preclinical studies have indicated that the activation of glucocorticoid receptor signaling results in inhibition of the growth of various types of tumors. Indeed, several glucocorticoids, such as dexamethasone and prednisone, have been prescribed for the treatment of, for example, hematological malignancies and castration-resistant prostate cancer. By contrast, the role of glucocorticoid-mediated glucocorticoid receptor signaling in the progression of bladder cancer remains far from being fully understood. Read More

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December 2018

Gestational Diabetes Mellitus in a Tertiary Care Hospital of Kolkata, India: Prevalence, Pathogenesis and Potential Disease Biomarkers.

Exp Clin Endocrinol Diabetes 2018 Dec 3. Epub 2018 Dec 3.

Department of Life Sciences, Presidency University, Kolkata, India.

Aims: Prevalence of gestational diabetes mellitus (GDM) may vary across a country like India. Risk factors and disease-pathogenesis were also not fully elucidated. This study aimed to examine prevalence of GDM among pregnant women visiting antenatal clinic of a tertiary-care hospital of Kolkata, India; possible mechanism of disease pathogenesis and potency of associated parameters as disease biomarkers were also explored. Read More

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December 2018
11 Reads

Cyclin-dependent protein serine/threonine kinase inhibitors as anticancer drugs.

Authors:
Robert Roskoski

Pharmacol Res 2018 Nov 30. Epub 2018 Nov 30.

Blue Ridge Institute for Medical Research, 3754 Brevard Road, Suite 116, Box 19, Horse Shoe, NC, 28742-8814, United States. Electronic address:

Cyclins and cyclin-dependent protein kinases (CDKs) are important proteins that are required for the regulation and expression of the large number of components necessary for the passage through the cell cycle. The concentrations of the CDKs are generally constant, but their activities are controlled by the oscillation of the cyclin levels during each cell cycle. Additional CDK family members play significant roles in a wide range of activities including gene transcription, metabolism, and neuronal function. Read More

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November 2018

Dimethyl fumarate and vitamin D derivatives cooperatively enhance VDR and Nrf2 signaling in differentiating AML cells in vitro and inhibit leukemia progression in a xenograft mouse model.

J Steroid Biochem Mol Biol 2018 Nov 30. Epub 2018 Nov 30.

Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105 Beer Sheva, Israel. Electronic address:

Acute myeloid leukemia (AML) is one of the deadliest hematological malignancies without effective treatment for most patients. Vitamin D derivatives (VDDs) - active metabolites 1α,25-dihydroxyvitamin D (1,25D2) and 1α,25-dihydroxyvitamin D (1,25D3) and their analogs - are differentiation-inducing agents which have potential for the therapy of AML. However, calcemic toxicity of VDDs limits their clinical use at doses effective against cancer cells in vivo. Read More

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November 2018
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Heterozygous Tsc2 (Tsc2+/-) Mouse Model to Study Induced Renal Cancer in Response to Ionizing Radiation at Low Doses.

Carcinogenesis 2018 Dec 2. Epub 2018 Dec 2.

Department of Pathology, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas USA.

Kidneys are one of the main dose-limiting organs in radio-therapeutic procedures of lower abdomen. Likewise, the threat of exposure of radio-sensitive organs such as kidneys in warfare or radiation accidents among military personal or due to terrorist activities in general public is of increasing concern. These events warrant the need for appropriate animal models to study the acute and chronic effects of low and high dose rate radiation exposures. Read More

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December 2018

E4F1 silencing inhibits the cell growth through cell-cycle arrest in malignant transformed cells induced by hydroquinone.

J Biochem Mol Toxicol 2018 Dec 1:e22269. Epub 2018 Dec 1.

Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, China.

Hydroquinone (HQ), one of the most significant metabolic activation products of benzene in an organism, can cause hematological toxicity, such as acute myeloid leukemia. It is a clear carcinogen that can cause changes in the disorder of cell cycle and cell growth. However, its molecular mechanisms remain unclear. Read More

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December 2018

Dose-dense paclitaxel/carboplatin as neo-adjuvant chemotherapy followed by radical surgery in locally advanced cervical cancer: a prospective phase II study.

Cancer Chemother Pharmacol 2018 Dec 1. Epub 2018 Dec 1.

Gynecologic Oncology Unit, Department of Women and Children Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Purpose: The role of dose-dense schedules in the neo-adjuvant treatment (NACT) of locally advanced cervical cancer (LACC) has been reported. This phase II study investigated activity of dose-dense paclitaxel/platinum before radical surgery (RS) in LACC patients.

Methods: The primary end-point was the rate of optimal pathological response (OPR: pathological complete/microscopic response). Read More

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December 2018

Common fetal hemoglobin variants in Lebanese patients bearing the codon 29 beta gene mutation associated with different thalassemia phenotypes.

Ann Hematol 2018 Nov 30. Epub 2018 Nov 30.

Department of Internal Medicine, American University of Beirut Medical Center, PO Box 11-0236, Beirut, 11072020, Lebanon.

Beta-thalassemia can present with a wide spectrum of phenotypes determined by the coinheritance of α-thalassemia, hereditary persistence of fetal hemoglobin, and polymorphic variants in the BCL11A, HMIP, and HBB clusters. The codon 29 (cd29) mutation in the beta gene has been associated with a broad diversity of thalassemia phenotypes, possibly through genetic modifiers determining the genotype-phenotype relationship. In this study, we evaluated the effect of 10 single nucleotide polymorphisms (SNPs) on β-thalassemia severity in a group of 21 Lebanese patients bearing the cd29 mutation. Read More

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November 2018

The utility of inflammation and platelet biomarkers in patients with acute coronary syndromes.

Saudi J Biol Sci 2018 Nov 24;25(7):1263-1271. Epub 2016 Oct 24.

Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, Poland.

Introduction: Thrombotic and inflammatory mechanisms are involved in the pathophysiology of acute coronary syndrome (ACS). The aim of the study was the evaluation of inflammation (white blood cells count/WBC, C-reactive protein/CRP, interleukin-6/IL-6) and platelet (platelet count/PLT, mean platelet volume/MPV, large platelet/LPLT, beta-thromboglobulin/β-TG) biomarkers in the groups of ACS patients depending on the severity of signs and symptoms and compared to controls without coronary artery disease.

Materials And Methods: The study group included 93 patients categorized into 3 subgroups depending on the severity of signs and symptoms of ACS. Read More

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November 2018

Shifting ground and gaps in transfusion support of patients with hematological malignancies.

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):553-560

Laboratory Medicine and Pathobiology (Transfusion Medicine) and Medicine (Clinical Hematology), University Health Network/University of Toronto, Toronto, ON, Canada.

The transfusion support of hematological malignancies considers 2 dimensions: the quantity of what we order (in terms of triggers, doses, targets, and intervals), and the special qualities thereof (with respect to depths of matching and appropriate product modifications). Meanwhile, transfusion-related enhancements in the quantity and quality of life may not be dose dependent but rather tempered by unintended patient harms and system strains from overexposure. Evidence and guidelines concur in endorsing clinically noninferior conservative red blood cell (RBC) transfusion care strategies (eg, triggering at hemoglobin <7-8 g/dL and in single-unit doses for stable, nonbleeding inpatients). Read More

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November 2018

Anticoagulating patients with high-risk acquired thrombophilias.

Authors:
Leslie Skeith

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):439-449

Division of Hematology and Hematological Malignancies, Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, Canada; and Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada.

Antiphospholipid syndrome (APS), heparin-induced thrombocytopenia, and paroxysmal nocturnal hemoglobinuria are 3 acquired thrombophilias that carry a high risk of venous and arterial thromboembolism. Management of these conditions has largely included anticoagulation with a vitamin K antagonist after an initial period of a parenteral anticoagulant, for as long as the thrombotic risk is still present. The available evidence for the use of direct oral anticoagulants (DOACs) is limited and primarily consists of case series and cohort studies, which are summarized in this chapter. Read More

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November 2018

Clinical consequences of clonal hematopoiesis of indeterminate potential.

Authors:
David P Steensma

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):264-269

Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA.

Clonally restricted hematopoiesis is a common aging-associated biological state that predisposes to subsequent development of a hematological malignancy or cardiovascular death. Clonal expansion driven by leukemia-associated somatic mutations, such as , , or , is best characterized, but oligoclonality can also emerge without recognized leukemia-driver mutations, perhaps as a result of stochastic neutral drift. Murine models provide compelling evidence that a major mechanism of increased cardiovascular mortality in the context of clonal hematopoiesis is accelerated atherogenesis driven by inflammasome-mediated endothelial injury, resulting from proinflammatory interactions between endothelium and macrophages derived from circulating clonal monocytes. Read More

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November 2018

Biology-driven developments in the therapy of acute graft-versus-host disease.

Authors:
Robert Zeiser

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):236-241

Department of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, Freiburg University Medical Center, Freiburg, Germany.

Allogeneic hematopoietic cell transplantation is a potentially curative treatment of different hematological malignancies. A major life-threatening complication is acute graft-versus-host disease (GVHD), in particular when the disease becomes steroid refractory. Based on the detection of pathogenic cytokines, chemokines, and T-cell subsets in individuals developing GVHD or experimental GVHD models, different therapeutic strategies have been developed. Read More

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November 2018

Hematological and psychophysiological correlates of anomalous information reception in mediums: A preliminary exploration.

Explore (NY) 2018 Aug 2. Epub 2018 Aug 2.

Windbridge Institute, 1517 N Wilmot Rd #254, Tucson, Arizona, USA.

Context: Modern research with mediums-individuals who regularly experience and report communication from the deceased-includes investigations of mediums' accuracy, psychology, phenomenology, and electrophysiology and the therapeutic potential of mediumship readings for the bereaved. Anecdotal reports imply that chronic medical problems may be a serious concern for mediums.

Objective: The aim of this study was two-fold: (I) to systematically investigate the hematological and psychophysiological correlates of anomalous information reception (AIR, the reporting of accurate and specific information about the deceased in the absence of prior knowledge, feedback, or deceptive means) and (II) to compare the reported health issues of mediums and non-mediums. Read More

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Differences in presenting features, outcome and prognostic models in patients with primary myelofibrosis and post-polycythemia vera and/or post-essential thrombocythemia myelofibrosis treated with ruxolitinib. New perspective of the MYSEC-PM in a large multicenter study.

Semin Hematol 2018 Oct 5;55(4):248-255. Epub 2018 Jun 5.

Institute of Hematology "L. and A. Seràgnoli", Sant'Orsola-Malpighi University Hospital, Bologna, Italy.

Recently, the myelofibrosis secondary to PV and ET prognostic model (MYSEC-PM) was introduced to assess prognosis in myelofibrosis (MF) secondary to polycythemia vera and essential thrombocythemia (post-PV and post-ET MF), replacing the International Prognostic Scoring System (IPSS) and/or Dynamic IPSS (DIPSS) that was applied for primary MF (PMF). In a cohort of 421 ruxolitinib (RUX)-treated patients (post-PV and post-ET MF: 44.2%), we evaluated the following: (1) disease phenotype, responses, and toxicity to RUX; and (2) performance of the MYSEC-PM in post-PV or post-ET MF. Read More

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October 2018

Bone Marrow Fibrosis and Early Hematological Response as Predictors of Poor Outcome in Azacitidine Treated High Risk-Patients With Myelodysplastic Syndromes or Acute Myeloid Leukemia.

Semin Hematol 2018 Oct 21;55(4):202-208. Epub 2018 Feb 21.

Hematology department, Hematology Unit, IRCCS Ca' Granda Ospedale Maggiore Policlinico and University of Milan, Milan, Italy.

Azacitidine (AZA) treatment is effective treatment for patients with myeloid disorders, and factors predictive of treatment outcome are under investigation. Little is known about the effect of bone marrow fibrosis on response to AZA therapy. We, retrospectively, evaluated clinical predictors of overall survival (OS) and overall response rate (ORR) for patients treated with AZA in a real-life cohort. Read More

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October 2018

Primary thromboembolic prevention in multiple myeloma patients: An exploratory meta-analysis on aspirin use.

Semin Hematol 2018 Oct 12;55(4):182-184. Epub 2017 Aug 12.

Department of Haematological Medicine, Guy's and St. Thomas' NHS Foundation Trust, London, UK.

Background: Multiple myeloma (MM) is a common hematological disorder, often complicated by venous thromboembolism, especially during treatment with immunomodulatory drugs. Acetylsalicylic acid (ASA) has been extensively used as thromboprophylaxis but its rationale is unclear and the efficacy versus low-molecular weight heparins (LMWH) is still matter of debate. European and American guidelines suggest different approaches and the optimal antithrombotic strategy is yet to be established. Read More

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October 2018

Outcome of invasive mechanical ventilation in cancer patients: Intubate or not to intubate a patient with cancer.

J Crit Care 2018 Nov 15;50:87-91. Epub 2018 Nov 15.

White Memorial Medical Center, Los Angeles, CA, United States.

Purpose: The outcome of cancer patients who undergo mechanical ventilation has been grim. However, it has lately become more promising, creating hesitation when approaching the decision to intubate a cancer patient. Therefore, the main goal was to find some factors that could predict mortality. Read More

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November 2018

Concomitant therapy with direct-acting antivirals and chemoimmunotherapy in HCV-associated diffuse large B-cell lymphoma.

Dig Liver Dis 2018 Nov 3. Epub 2018 Nov 3.

Hepatology Unit, San Giuseppe Hospital, University of Milan, Milan, Italy.

Introduction: The association between hepatitis C virus (HCV) infection and B-cell non-Hodgkin's Lymphomas (NHL) is well established. Antiviral therapy (AVT) is the first-line treatment for HCV-related indolent NHL whereas diffuse large B-cell lymphoma (DLBCL) requires immediate start of chemoimmunotherapy (CIT), usually deferring AVT. However, an early HCV elimination may reduce the risk of CIT-induced liver toxicity and consequent CIT interruption or withdrawal. Read More

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November 2018

Olive leaf tea may have hematological health benefit over green tea.

Clin Nutr 2018 Nov 20. Epub 2018 Nov 20.

Alliance for Research on the Mediterranean and North Africa (ARENA), University of Tsukuba, Tsukuba, Japan; Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan. Electronic address:

Olive leaf extracts are rich in several polyphenols having potential health benefits. We conducted the current parallel-group randomized controlled trial to compare the effects of long-term consumption of olive leaf tea (OLT) and green tea (GT) on hematological parameters in 31 female volunteers aged between 40 and 70 years of old. We found that RBC count, hemoglobin, and hematocrit were increased significantly in the OLT group than those of in the GT group at 6 and 12 weeks of intervention. Read More

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November 2018

The impact of NF-κB signaling on pathogenesis and current treatment strategies in multiple myeloma.

Blood Rev 2018 Nov 23. Epub 2018 Nov 23.

Babak Myeloma Group, Department of Pathological Physiology, Masaryk University, Brno, Czech Republic. Electronic address:

Multiple myeloma, which ranks as the second most common hematological malignancy, is known for its great genetic heterogeneity. One pathway, however, stands out in this diverse group. NF-κB pathway is one of the most important pathways in multiple myeloma not only for its role in pathogenesis, but also for its importance in various treatment strategies. Read More

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November 2018

[Regulation of the Megakaryocyte Development and the Platelet Production--Review].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Dec;26(6):1876-1880

Department of Pediatrics, Affiliated Hospital of Southwest Medical University, Pediatric Hematological Tumor PI Laboratory, Luzhou 646000, Sichuan Province, China E-mail:

The main physiological function of megakaryocytes is the production of platelets, whose development, maturation and platelet production are a complex regulatory process, and are involved in many factors. In recent years it was found that the lung is also the main site of megakaryocyte-producing platelets in addition to bone marrow. Based on the findings of recent years, this review summarizes the process of megakaryocyte development, maturation and platelet production, with emphasis on the analyzing the regulatory effects of apoptotic factors, miRNA, thrombopoietin and its receptors, interleukins, transcription factors and their corresponding signal pathways on platelet production. Read More

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December 2018

[Potential Value of Cancer-Associated Fibroblasts in Hematological Malignancies--Review].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Dec;26(6):1872-1875

Department of Hematology, The Affiliated Hospital of Guizhou Medical University, Guiyang 550001, Guizhou Province, China E-mail:

Cancer-associated fibroblasts (CAF), as one of the most important components of tumor microenvironment, which plays important role in tumorigenesis, development, infiltration and metastasis of cancers. In a variety of solid tumors, CAF can even determine the fate of tumor cells. In view of its pivotal role in promoting tumor progression, CAF has recently become a therapeutic target for a variety of tumors. Read More

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December 2018

[Study on Immunophenotypes and Gene of Acute Lymphoblastic Leukemia--Review].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Dec;26(6):1831-1835

Hematology Oncology Center, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing Key Laboratory of Hematological Diseases and Tumor Molecular Classification, National Key Discipline of Pediatrics, Beijing 100045, China.

Transplantation-associated thrombotic microangiopathy (TA-TMA) is one of the fatal complications of hematopoietic stem cell transplantation(HSCT). The pathogenesis of TA-TMA has not been fully elucidated. The latest researches show that the abnormal activation of the complement system may lead to widespread endothelial injury which may play an important role in the pathogenesis of this disease. Read More

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December 2018

Audit of toxic effects of body paint in the Tiger dancers (Hulivesha) of Mangalore, India: an investigational study.

Cutan Ocul Toxicol 2018 Dec 2:1-26. Epub 2018 Dec 2.

h Father Muller Research Centre, Kankanady , Mangalore , India 575002.

Introduction: Tiger dancing or Hulivesha, where the volunteers paint their bare body like a tiger and dance is a ritual during the Navaratri festival in Mangalore, India. There are no scientific studies done with the hulivesha dancers at all and therefore we investigated the adverse effects of painting body like a tiger and dancing in the volunteers.

Objective/aim: In this study we investigated the clinicohematological effects of topical application of lead containing paint and dancing for three consecutive days in these dancers to ascertain the toxic effects of whole body painting and dancing. Read More

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December 2018

[Invasive Fusariosis: Report of Three Cases in Peru].

Rev Peru Med Exp Salud Publica 2018 Jul-Sep;35(3):523-526

Hospital Nacional Guillermo Almenara. Lima, Perú.

Fusarium species are a group of fungi that cause superficial infections, locally invasive and disseminated disease, which occur mainly in immunocompromised hosts, and occasionally in immunocompetent individuals. We present three cases that show three different clinical forms of Fusarium spp. disease that affected different types of patients (patients with hematological malignancy, chronic kidney disease in peritoneal dialysis and post-surgical for osteoarticular pathology), each with its own characteristics that merit discussion. Read More

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October 2017
1 Read

Review of a three-year study on the dental care of onco-hematological pediatric patients.

Clinics (Sao Paulo) 2018 Dec 3;73:e721. Epub 2018 Dec 3.

Instituto da Crianca (ICr), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

The aim of this study was to provide an updated review of dental procedures undertaken at the dental unit of the Onco-hematology service of the Instituto da Criança at the Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (ICr/HC-FMUSP). We retrospectively reviewed 565 of 1902 medical and dental records of patients diagnosed with onco-hematological diseases who were seen in a 3-year study (January 2015 to December 2017). We assessed data regarding population characteristics, onco-hematological diagnosis and dental procedures performed. Read More

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December 2018
2 Reads

Real-world treatment outcomes in multiple myeloma: Multicenter registry results from Finland 2009-2013.

PLoS One 2018 5;13(12):e0208507. Epub 2018 Dec 5.

Janssen Cilag AB, Solna, Sweden.

Outcomes for patients with multiple myeloma (MM) have improved with the advent of novel therapies, however, real-world evidence of outcomes in clinical practice is scarce. We conducted a multi-center registry study to build a reliable picture of treatment and patient outcomes in Finland. The aim of this study was also to understand any methodological challenges in assessing treatment outcomes using disease registry data. Read More

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December 2018
1 Read

Aberrant histone modifications induced by mutant ASXL1 in myeloid neoplasms.

Int J Hematol 2018 Dec 5. Epub 2018 Dec 5.

Division of Cellular Therapy, Advanced Clinical Research Center, Division of Stem Cell Signaling, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 1088639, Japan.

An epigenetic modulator Additional sex combs-like 1 (ASXL1) is recurrently mutated in myeloid neoplasms such as myelodysplastic syndromes (MDS), acute myeloid leukemia (AML) and myeloproliferative neoplasms (MPNs). ASXL1 mutations are also frequently detected in clonal hematopoiesis with indeterminate potential (CHIP), which is the clonal expansion of premalignant hematopoietic cells without any evidence of hematological malignancies. Thus, understanding the roles of ASXL1 in hematopoiesis and myeloid neoplasms is a clinically crucial issue. Read More

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December 2018

Identification of Deregulated Signaling Pathways in Jurkat Cells in Response to a Novel Acylspermidine Analogue-N-Erucoyl Spermidine.

Epigenet Insights 2018 27;11:2516865718814543. Epub 2018 Nov 27.

Biochemistry Department, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

Natural polyamines such as putrescine, spermidine, and spermine are crucial in the cell proliferation and maintenance in all the eukaryotes. However, the requirement of polyamines in tumor cells is stepped up to maintain tumorigenicity. Many synthetic polyamine analogues have been designed recently to target the polyamine metabolism in tumors to induce apoptosis. Read More

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November 2018

Peripheral Lymphocytes of Patients with Inflammatory Bowel Disease Have Altered Concentrations of Key Apoptosis Players: Preliminary Results.

Biomed Res Int 2018 1;2018:4961753. Epub 2018 Nov 1.

Department of Medical Biochemistry, Wroclaw Medical University, 50-368 Wroclaw, Poland.

Notwithstanding uncertain pathogenesis of inflammatory bowel disease (IBD), deregulation of adaptive immunity is paramount for the development of inflammation. Essential role in the resolution of inflammation is played by apoptosis, deregulated in lymphocytes isolated from inflamed intestine. Despite IBD being a systemic disease, little is known about apoptosis of peripheral lymphocytes. Read More

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November 2018
1 Read

Evaluation of antiproteinuric and hepato-renal protective activities of propolis in paracetamol toxicity in rats.

Nutr Res Pract 2018 Dec 23;12(6):535-540. Epub 2018 Nov 23.

Laboratory Physiology-Pharmacology & Environmental Health, Faculty of Sciences Dhar El Mehraz, University Sidi Mohamed Ben Abdallah, Fez 30000, Morocco.

Background/objectives: Propolis has a rich source of bioactive compounds and has renal and hepatic protective properties. The purpose of this study was to investigate the beneficial effect of hydro-ethanolic extract of propolis against paracetamol-induced liver damage and impairment of kidney function, as well as hematological changes in rats.

Materials And Methods: Six groups of rats were used; the first group was served as a control; the second and third groups were treated by propolis extract at a dose of 50 and 100 mg/kg. Read More

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December 2018

[Red blood cell distribution width is a independent prognostic indicator for mortality in patients with HBV related acute-on-chronic liver failure].

Nan Fang Yi Ke Da Xue Xue Bao 2018 Nov;38(11):1354-1359

Department of Infectious Diseases, Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.

Objective: To establish a model for predicting the short-term prognosis of patients with HBV-related acute-onchronic liver failure (HBV-ACLF) based on red blood cell distribution width (RDW) and the model for end-stage liver disease (MELD) scores.

Methods: A total of 245 patients with HBV-ACLF were retrospectively analyzed for their clinical data and results of routine hematological tests, liver function, renal function, coagulation test, HBV-DNA, and other indicators at admission. Univariate analysis and binary logistic regression analysis were used to test the short-term risk factors for death of the patients, and the MELD-RDW model was established. Read More

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November 2018

A study of clinical, hematological, and biochemical profiles of patients with dengue viral infections in Northwest Ethiopia: implications for patient management.

BMC Infect Dis 2018 Dec 4;18(1):616. Epub 2018 Dec 4.

Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Dengue is one of the most common arboviral diseases with increased outbreaks annually in tropical and subtropical areas. In Ethiopia, there are no data regarding clinical, hematological and biochemical parameters which are very important in the clinical management of dengue patients. Hence this study was carried out to provide the first baseline data of clinical, hematological and biochemical profiles of patients infected with dengue virus. Read More

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December 2018

ANNALS EXPRESS: Autotaxin and sIL-2R levels in cerebrospinal fluids are useful for the diagnosis of central nervous system invasion caused by hematological malignancies.

Ann Clin Biochem 2018 Dec 4:4563218818197. Epub 2018 Dec 4.

The University of Tokyo.

Background: Invasion of the central nervous system (CNS) by hematological malignancies is diagnosed by cytological analyses of cerebrospinal fluid (CSF) or diagnostic imaging, while quantitative biomarkers for CNS invasion are not available and needed to be developed. Methods; In this study, we measured the levels of autotaxin (ATX) and soluble IL-2 receptor (sIL-2R) in cerebrospinal fluid (CSF) and evaluated their usefulness as biomarkers for CNS invasion.

Results: We observed that both the ATX and sIL-2R levels in CSF were higher in subjects with CNS invasion than in those without, and the CSF levels were independent from the serum levels of these biomarkers. Read More

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December 2018

The reparative effects of human adipose-derived mesenchymal stem cells in the chemotherapy damaged thymus.

Stem Cells Dev 2018 Dec 4. Epub 2018 Dec 4.

The Second Hospital of Hebei Medical University, Hematology, Shijiazhuang, Hebei, China ;

Hematological patients who accept chemotherapy always develop secondary tumor or even die of severe infections. As an important central lymphoid organ, the thymus is frequently damaged during chemotherapy. Previous studies showed that the mesenchymal stem cells (MSCs) can promote the proliferation and repair of epithelial cells in thymus. Read More

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December 2018

The effects of common yarrow (Achillea millefolium Linnaeus), cinnamon (Cinnamomum zeylanicum Blume) and rosemary (Rosemarinus officinalis Linnaeus) hydrosols on the some immunological and hematological parameters of common carp (Cyprinus carpio L., 1758).

Cell Mol Biol (Noisy-le-grand) 2018 Nov 30;64(14):19-24. Epub 2018 Nov 30.

Fisheries Faculty, Munzur University, TR62000, Tunceli, Turkey.

In this study, the effects of some plant hydrosols (distilled plant waters) based upon some hematological parameters and Nitroblue Tetrazolium (NBT) activities in the common carp (Cyprinus carpio Linnaeus, 1758) infected with Yersinia ruckeri were investigated. In the trial, it was utilized totally 200 common carps with 54.3±6. Read More

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November 2018

Salvage and bridging to allogeneic hematopoietic cell transplantation with ponatinib in patients with relapsed or refractory Philadelphia chromosome-positive leukemia.

Int J Hematol 2018 Dec 3. Epub 2018 Dec 3.

Department of Hematology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, Yokohama, 241-8515, Japan.

A single-center retrospective study was performed with consecutive patients who received salvage therapy using ponatinib for the aim of allogeneic hematopoietic cell transplantation (HCT) for relapsed or refractory Ph-leukemia between January 2017 and July 2018. A total of ten patients-seven with Ph-acute lymphoblastic leukemia (ALL) and three with chronic phase (CP)/accelerated phase chronic myeloid leukemia (CML)-were eligible. Eight patients had a history of a single tyrosine kinase inhibitor (TKI) use prior to ponatinib. Read More

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December 2018