3,367 results match your criteria Hemangiomas Hepatic


Radiomics analysis of contrast-enhanced CT for classification of hepatic focal lesions in colorectal cancer patients: its limitations compared to radiologists.

Eur Radiol 2021 May 10. Epub 2021 May 10.

Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Objective: To evaluate diagnostic performance of a radiomics model for classifying hepatic cyst, hemangioma, and metastasis in patients with colorectal cancer (CRC) from portal-phase abdominopelvic CT images.

Methods: This retrospective study included 502 CRC patients who underwent contrast-enhanced CT and contrast-enhanced liver MRI between January 2005 and December 2010. Portal-phase CT images of training (n = 386) and validation (n = 116) cohorts were used to develop a radiomics model for differentiating three classes of liver lesions. Read More

View Article and Full-Text PDF

[Clinicopathological characteristics of hepatic epithelioid haemangioendothelioma].

Zhonghua Bing Li Xue Za Zhi 2021 May;50(5):511-513

Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

View Article and Full-Text PDF

Cutaneous and hepatic vascular lesions due to a recurrent somatic mutation reveal a pathway for vascular malformation.

HGG Adv 2021 Apr 1;2(2). Epub 2021 Mar 1.

Department of Dermatology, School of Medicine, Yale University, New Haven, CT 06510, USA.

The term "cavernous hemangioma" has been used to describe vascular anomalies with histology featuring dilated vascular spaces, vessel walls consisting mainly of fibrous stromal bands lined by a layer of flattened endothelial cells, and an irregular outer rim of interrupted smooth muscle cells. Hepatic hemangiomas (HHs) and cutaneous venous malformations (VMs) share this histologic pattern, and we examined lesions in both tissues to identify genetic drivers. Paired whole-exome sequencing (WES) of lesional tissue and normal liver in HH subjects revealed a recurrent c. Read More

View Article and Full-Text PDF

A case of diffuse hepatic hemangiomatosis coexistent with giant hemangioma: case report and literature review.

Radiol Case Rep 2021 Jun 17;16(6):1518-1523. Epub 2021 Apr 17.

Body Imaging, Radiology Department, IBERORAD, Barcelona, Spain.

We report a case of hepatic hemangiomatosis coexistent with a giant hepatic hemangioma diagnosed in the context of the study for SARS-CoV-2 infection. Computed tomography showed irregular contours of the left hepatic lobe with a lesion that compromised the whole lobe, with peripheral uptake and a centripetal tendency in the late phase, compatible with bulky cavernous hemangioma, as well as another lesion with the same characteristics in segment VI. Magnetic resonance imaging of the abdomen showed multiple hepatic hemangiomas observed in both lobes involving all segments, some of them smaller than 1 cm, which were hyperintense in the T2-weighted sequences and showed progressive contrast enhancement. Read More

View Article and Full-Text PDF

Primary malignant vascular tumors of the liver in children: Angiosarcoma and epithelioid hemangioendothelioma.

World J Gastrointest Oncol 2021 Apr;13(4):223-230

Department of Paediatric Laboratory Medicine, Hospital for Sick Children, 555 University Ave, Toronto M5G 1X8, Ontario, Canada.

Primary malignant vascular neoplasms of the liver, angiosarcoma and epithelioid hemangioendothelioma, are extremely rare entities in the pediatric population. International Society for the Study of Vascular Anomalies classification system is recommended for the pathologic diagnosis of hepatic vascular lesions in this age group. In this article, we highlight the clinicopathologic characteristics of hepatic angiosarcoma and epithelioid hemangioendothelioma in the pediatric population. Read More

View Article and Full-Text PDF

Chitinase 3-like 1 is a profibrogenic factor overexpressed in the aging liver and in patients with liver cirrhosis.

Proc Natl Acad Sci U S A 2021 Apr;118(17)

Hepatic Pathogenesis Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892;

Older age at the time of infection with hepatitis viruses is associated with an increased risk of liver fibrosis progression. We hypothesized that the pace of fibrosis progression may reflect changes in gene expression within the aging liver. We compared gene expression in liver specimens from 54 adult donors without evidence of fibrosis, including 36 over 40 y old and 18 between 18 and 40 y old. Read More

View Article and Full-Text PDF

Joint segmentation and classification of hepatic lesions in ultrasound images using deep learning.

Eur Radiol 2021 Apr 21. Epub 2021 Apr 21.

Medical Imaging R&D Group, Health & Medical Equipment Business, Samsung Electronics Co., Ltd., Seoul, Republic of Korea.

Objectives: To develop a convolutional neural network system to jointly segment and classify a hepatic lesion selected by user clicks in ultrasound images.

Methods: In total, 4309 anonymized ultrasound images of 3873 patients with hepatic cyst (n = 1214), hemangioma (n = 1220), metastasis (n = 1001), or hepatocellular carcinoma (HCC) (n = 874) were collected and annotated. The images were divided into 3909 training and 400 test images. Read More

View Article and Full-Text PDF

Superb microvascular imaging technology of ultrasound examinations for the evaluation of tumor vascularity in hepatic hemangiomas.

Ultrasonography 2021 Feb 14. Epub 2021 Feb 14.

Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Purpose: This study aimed to investigate and categorize the diverse features of hepatic hemangiomas on superb microvascular imaging (SMI) in a relatively large prospective study.

Methods: In this prospective study, 70 patients with 92 hepatic hemangiomas were consecutively enrolled. All nodules were radiologically confirmed with the typical imaging features of hepatic hemangiomas on dynamic computed tomography (CT) or magnetic resonance imaging (MRI). Read More

View Article and Full-Text PDF
February 2021

Outcomes of surgery for giant hepatic hemangioma.

BMC Surg 2021 Apr 8;21(1):186. Epub 2021 Apr 8.

Hepatopancreatobiliary Surgery, Department of general surgery, The First Affiliated Hospital of Anhui Medical University, 120# Wanshui Road, Hefei, 230022, Anhui, China.

Background: The surgical indications for liver hemangioma remain unclear.

Methods: Data from 152 patients with hepatic hemangioma who underwent hepatectomy between 2004 and 2019 were retrospectively reviewed. We analyzed characteristics including tumor size, surgical parameters, and variables associated with Kasabach-Merritt syndrome and compared the outcomes of laparoscopic and open hepatectomy. Read More

View Article and Full-Text PDF

Multilocular cystic hemangioma of the liver mimicking mucinous cystic neoplasm.

Yeungnam Univ J Med 2021 Apr 7. Epub 2021 Apr 7.

Department of Surgery, Biomedical Research Institute and Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.

Hepatic hemangiomas infrequently exhibit atypical imaging features, which may cause diagnostic confusion with hepatic malignancies and lead to unnecessary surgery. We report a rare case of multilocular cystic hemangioma of the liver mimicking a mucinous cystic neoplasm of the liver in a 48-year-old female, focusing on computed tomography and magnetic resonance imaging features and their differential diagnosis. Read More

View Article and Full-Text PDF

CXCL12-CXCR4-Mediated Chemotaxis Supports Accumulation of Mucosal-Associated Invariant T Cells Into the Liver of Patients With PBC.

Front Immunol 2021 19;12:578548. Epub 2021 Mar 19.

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

To explore the potential role of CD3CD8CD161 TCRVα7.2 mucosal-associated invariant T (MAIT) cells in the pathogenesis of primary biliary cholangitis (PBC). We enrolled 55 patients with PBC, 69 healthy controls (HCs), and 8 patients with hepatic hemangioma. Read More

View Article and Full-Text PDF

Rapidly involuting congenital hemangioma of the liver in a newborn with incomplete Pentalogy of Cantrell: description of a new association.

J Surg Case Rep 2021 Mar 22;2021(3):rjab047. Epub 2021 Mar 22.

Department of Paediatric and Adolescent Surgery, Medical University of Graz, Graz, Austria.

The perinatal management of newborns with giant omphaloceles requires careful suspicion concerning 'unexpected' associated malformations. We describe a newborn with a combination of incomplete Pentalogy of Cantrell consisting of giant omphalocele, anterior congenital diaphragmatic hernia (CDH) and pericardial absence complicated by a hepatic rapidly involuting congenital hemangioma (RICH). A giant omphalocele was detected prenatally. Read More

View Article and Full-Text PDF

Two hepatic cavernous hemangiomas mimicking colorectal liver metastasis: A rare case report.

Int J Surg Case Rep 2021 Apr 23;81:105817. Epub 2021 Mar 23.

Department of General Surgery, Colorectal Surgery Section, King Fahad Specialist Hospital-Dammam, Dammam, Saudi Arabia.

Introduction: Hepatic cavernous hemangioma (HCH) is a common benign lesion of the liver. The radiological features of HCH can resemble those of hepatic malignancies such as metastatic liver cancer, which make the preoperative definitive diagnosis difficult.

Presentation Of Case: We report the case of a 77-year-old woman who presented with a 2-month history of abdominal pain and per rectum fresh bleeding. Read More

View Article and Full-Text PDF

Association of tumor size and internal echo pattern with coagulopathy associated with hepatic hemangioma.

Mol Clin Oncol 2021 Apr 26;14(4):83. Epub 2021 Feb 26.

Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8504, Japan.

Little is known concerning causal factors associated with the size and echogenicity of hepatic hemangiomas. The aim of the present study was to investigate the associations between tumor size and echo pattern and coagulation factors, and to elucidate the growth pattern of hemangiomas. In 214 consecutive patients with hepatic hemangiomas, ultrasonography was performed to determine total tumor number, size, echogenicity and location, and serum laboratory tests for liver function and coagulation factors were carried out. Read More

View Article and Full-Text PDF

Post-resection prognosis of patients with hepatic epithelioid hemangioendothelioma.

Ann Surg Treat Res 2021 Mar 26;100(3):137-143. Epub 2021 Feb 26.

Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: Epithelioid hemangioendothelioma (EHE) is a rare borderline vascular tumor. This retrospective, single-center study evaluated the outcomes of hepatic resection (HR) in patients with hepatic EHE.

Methods: Over the 10-year period from 2009 to 2018, 11 patients with hepatic EHE underwent HR, accounting for 0. Read More

View Article and Full-Text PDF

Successful Management of Massive Congenital Hepatic Hemangioma and Systemic Hypertension With Sirolimus.

J Pediatr Hematol Oncol 2021 May 5. Epub 2021 May 5.

Department of Pediatrics, Chonnam National University Children's Hospital Department of Pediatrics, Chonnam National University Medical School Department of Radiology, Chonnam National University Hospital, Gwangju Department of Pediatrics Department of Pathology, Chonnam National University Hwasun Hospital, Hwasun, Korea.

Congenital hepatic hemangioma (CHH) is a common benign vascular tumor of the liver, seen in infancy. The clinical manifestations vary from incidental findings to life-threatening complications. The authors present here a case of an infant with massive CHH who developed systemic hypertension because of compression of the right renal artery by the CHH and did not respond to other lines of treatment. Read More

View Article and Full-Text PDF

Quantitative analysis of gadoxetic acid-enhanced MRI for the differential diagnosis of focal liver lesions: Comparison between estimated intralesional gadoxetic acid retention by T1 mapping and conventional processing methods.

Eur J Radiol 2021 May 1;138:109620. Epub 2021 Mar 1.

Department of Diagnostic Radiology, Saitama Medical University International Medical Center, 350-1298, Yamane 1397-1, Hidaka, Saitama, Japan.

Purpose: To compare the estimated quantity of intratumor gadoxetic acid retention using T1 mapping of gadoxetic acid-enhanced magnetic resonance imaging (MRI) versus conventional processing methods for the differential diagnosis of focal liver lesions.

Methods: Seventy patients with hepatic lesions (colorectal metastasis (CRM) [n = 28], hepatocellular carcinoma (HCC) [n = 20], hemangioma [n = 12], and intrahepatic cholangiocarcinoma (ICC) [n = 10]) underwent gadoxetic acid-enhanced MRI, including pre- and post-contrast T1-weighted imaging and T1 mapping. Quantitative analyses included the lesion-to-liver signal intensity ratio (SIR) on hepatobiliary phase images, the pre- and post-contrast lesion T1 value difference (ΔT1 [ms]), and the lesion retention index (LRI [%]), which was the estimated intralesional gadoxetic acid retention calculated on pre- and post-contrast T1 maps using a two-compartment pharmacokinetic model. Read More

View Article and Full-Text PDF

Liver Tumors in Pediatric Patients.

Surg Oncol Clin N Am 2021 Apr;30(2):253-274

Division Pediatric Surgery, Cincinnati Children's Hospital and Medical Center, 3333 Burnet Ave, Cincinnati, Ohio 45229, USA.

The most recent advance in the care of children diagnosed with hepatoblastoma and hepatocellular carcinoma is the Pediatric Hepatic International Tumor Trial, which opened to international enrollment in 2018. It is being conducted as a collaborative effort by the pediatric multicenter trial groups in North America, Europe, and the Far East. This international effort was catalyzed by a new unified global risk stratification system for hepatoblastoma, an international histopathologic consensus classification for pediatric liver tumors, and a revised 2017 collaborative update of the PRE-Treatment EXTent of disease radiographic based staging system. Read More

View Article and Full-Text PDF

Indocyanine green fluorescence imaging-guided laparoscopic right posterior hepatectomy.

Surg Endosc 2021 Mar 8. Epub 2021 Mar 8.

Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.

Background: Laparoscopic right posterior hepatectomy is considered difficult on the basis of the surgery difficulty scoring system. In this study, we evaluated the safety and effectiveness of the technical application of indocyanine green (ICG) fluorescence imaging-guided laparoscopic right posterior hepatectomy.

Methods: Twenty-six patients who underwent ICG fluorescence imaging-guided laparoscopic right posterior hepatectomy at Hepatobiliary and Pancreatic Surgery Department of Zhongnan Hospital, Wuhan University, from June 2018 to December 2019, were included. Read More

View Article and Full-Text PDF

Pediatric Primary Hepatic Tumors: Diagnostic Considerations.

Diagnostics (Basel) 2021 Feb 18;11(2). Epub 2021 Feb 18.

Rainbow Babies and Children's Hospital-Department of Pediatric Hematology and Oncology, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.

The liver is the third most common site of abdominal tumors in children. This review article aims to summarize current evidence surrounding identification and diagnosis of primary hepatic tumors in the pediatric population based upon clinical presentation, epidemiology, and risk factors as well as classical imaging, histopathological, and molecular diagnostic findings. Readers will be able to recognize the features and distinguish between benign and malignant hepatic tumors within different age groups. Read More

View Article and Full-Text PDF
February 2021

Proton beam therapy for a giant hepatic hemangioma: A case report and literature review.

Clin Transl Radiat Oncol 2021 Mar 3;27:152-156. Epub 2021 Feb 3.

Department of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.

Background: Hepatic hemangiomas are benign tumors with a favorable prognosis, but giant hepatic hemangiomas can cause abdominal symptoms and are indicated for treatment. Most cases are treated with surgery, but radiotherapy has also been used. However, to date, there have been no reports of proton beam therapy for a hepatic hemangioma. Read More

View Article and Full-Text PDF

Laparoscopic versus open surgery in the treatment of hepatic hemangioma: A meta-analysis.

Authors:
He Jien Li Xiaohua

Medicine (Baltimore) 2021 Feb;100(8):e24155

Department of Radiotherapy, Baoji Central Hospital, China.

Background: The aim of this study was to systematically evaluate and compare the effectiveness and safety of laparoscopic versus open resection (LR vs OR) in the treatment of hepatic hemangioma.

Methods: We searched PubMed, the Cochrane Library, Web of Science, Medline, EMBASE, and the Chinese Biomedicine Database from January 2000 to April 2020 for studies comparing the outcomes of laparoscopic versus open surgery in hepatic hemangioma treatment.

Results: Based on the preset criteria, 12 randomized clinical trials (RCTs) and 12 observational clinical studies (OCSs) were selected for analysis. Read More

View Article and Full-Text PDF
February 2021

Metastatic neuroblastoma masquerading as infantile hemangioma in a 4-month-old child.

Pediatr Blood Cancer 2021 May 28;68(5):e28920. Epub 2021 Feb 28.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Introduction: Diffuse liver lesions in an infant have a differential diagnosis including infantile hemangioma (IH), which is common in the first year of life, and neuroblastoma (NBL) which presents at a median age of 18 months.

Results: We describe the case of a 4-month-old girl with a known superficial/deep IH who presented with new axillary nodules and hepatosplenomegaly, initially suspected to reflect IH but later determined to be widely metastatic NBL.

Conclusion: Hepatic IH and metastatic NBL can present similarly. Read More

View Article and Full-Text PDF

Combining On-Table Embolization with Immediate Resection to Safely Excise Giant Hepatic Hemangiomas.

J Gastrointest Surg 2021 Feb 25. Epub 2021 Feb 25.

Creticos Cancer Center at Advocate Illinois Masonic Medical Center, Chicago, IL, USA.

The management of symptomatic giant hepatic hemangiomas (> 10 cm) varies in the literature. Multiple interventional approaches have been described including surveillance, embolization, enucleation, and resection based on tumor size, location, relationship to vascular and biliary structures, and the quality and quantity of the functional liver remnant. Resection is often performed as a last resort due to the risk of major hemorrhage. Read More

View Article and Full-Text PDF
February 2021

Cholangiocarcinoma - Part 2, Tumoral and Nontumoral Mimics and Imaging Features Helpful in Differentiation.

Curr Probl Diagn Radiol 2021 Feb 7. Epub 2021 Feb 7.

Department of Diagnostic Radiology, Khoo Teck Puat Hospital, Singapore, Republic of Singapore. Electronic address:

Each of the 3 morphological subtypes of cholangiocarcinoma has a different set of imaging differentials. Emulators of mass-forming cholangiocarcinoma include other primary and secondary hepatic malignancies, benign tumors and tumor-like mimics such as abscess, hemangioma and confluent hepatic fibrosis. Benign inflammatory biliary strictures constitute the major differential of periductal-infiltrative type and intraductal calculi are the main consideration for intraductal-growth type. Read More

View Article and Full-Text PDF
February 2021

Clinical Characteristics and Prognostic Factors in Pediatric Vascular Tumors.

Pediatric Health Med Ther 2021 16;12:43-53. Epub 2021 Feb 16.

Division of Hematology/Oncology, Department of Pediatrics, Phramongkutklao Hospital and Phramongkutklao College of Medicine, Bangkok, Thailand.

Background: The most common type of vascular tumors reported among children is hemangioma. The determinant factors to predict clinical outcomes among those patients were not well studied.

Objective: The study aimed to explore clinical characteristics and treatment approaches as well as associated prognostic factors of vascular tumors specifically in a pediatric population. Read More

View Article and Full-Text PDF
February 2021

Evaluation of the Effect of Patient Preparation Using Castor Oil on ADC Value of Focal Liver Lesion.

Int J Gen Med 2021 16;14:469-474. Epub 2021 Feb 16.

University of Sulaimani, College of Medicine, Department of Surgery-Diagnostic Imaging Unit, Sulaymaniyah, Kurdistan Region, Iraq.

Purpose: To estimate the role of patient preparation using castor oil on the ADC value of focal liver lesion.

Patients And Methods: Retrospective case-control study over more than two years. Magnetic resonance imaging (MRI) scan, including diffusion-weighted imaging (DWI) of the upper abdomen performed for 87 cases and 71 controls in patients with focal hepatic hemangiomas. Read More

View Article and Full-Text PDF
February 2021

Spontaneous intracapsular hemorrhage of a giant hepatic cavernous hemangioma: a rare case report and literature review.

BMC Gastroenterol 2021 Feb 23;21(1):84. Epub 2021 Feb 23.

Department of Hepatobiliary Surgery, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, People's Republic of China.

Background: Hepatic cavernous hemangioma is the most common type of benign liver tumor. Although ruptures and hemorrhages of hepatic hemangioma are rare complications, they are associated with high mortality. Most practitioners only pay more attention to abdominal hemorrhages caused by the rupture of hepatic hemangiomas. Read More

View Article and Full-Text PDF
February 2021

Bland Embolization of Benign Liver Tumors: Review of the Literature and a Single Center Experience.

J Clin Med 2021 Feb 9;10(4). Epub 2021 Feb 9.

Division of Vascular and Interventional Radiology, Mayo Clinic Arizona, Phoenix, AZ 85054, USA.

Transarterial embolization has shown promise as a safe, effective, and less invasive treatment modality for benign liver lesions (hemangioma, focal nodular hyperplasia (FNH), and hepatic adenoma (HA)) with fewer complications compared to surgical intervention. There is no consensus regarding the most appropriate embolization material(s) for the treatment of benign liver tumors. The purpose of this study was to review the current literature regarding the transarterial embolization of benign liver tumors and to share our single center experience. Read More

View Article and Full-Text PDF
February 2021