38,713 results match your criteria Hemangiomas Hepatic
BMC Ophthalmol 2018 Dec 13;18(1):321. Epub 2018 Dec 13.
Department of Ophthalmology, Eye and ENT Hospital, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
Background: Changes in retinal fluid patterns associated with circumscribed choroidal hemangioma (CCH) have not been investigated yet. A long-term follow-up study was performed to evaluate the changes of retinal fluid patterns and treatment responses.
Methods: We retrospectively reviewed medical records of all CCH patients diagnosed between November 2005 and March 2017. Read More
MAbs 2018 Dec 12:1-19. Epub 2018 Dec 12.
a UltraHuman Limited, Codebase , Edinburgh , UK.
Monoclonal anti-programmed cell death 1 (PD1) antibodies are successful cancer therapeutics, but it is not well understood why individual antibodies should have idiosyncratic side-effects. As the humanized antibody SHR-1210 causes capillary hemangioma in patients, a unique toxicity amongst anti-PD1 antibodies, we performed human receptor proteome screening to identify nonspecific interactions that might drive angiogenesis. This screen identified that SHR-1210 mediated aberrant, but highly selective, low affinity binding to human receptors such as vascular endothelial growth factor receptor 2 (VEGFR2), frizzled class receptor 5 and UL16 binding protein 2 (ULBP2). Read More
Biomed Microdevices 2018 Dec 6;20(4):100. Epub 2018 Dec 6.
Department of Pharmaceutical Science and Experimental Therapeutics, University of Iowa College of Pharmacy, 115 South Grand Avenue, Iowa City, IA, 52242, USA.
Topical beta-blocker formulations are commonly used to treat infantile hemangiomas (IHs); however, the skin concentrations and drug permeation through the skin have not been quantified. Microneedles (MNs) may increase local skin concentrations, which could further enhance lesion clearance and improve dosing regimens. The objective of this study was to quantify skin concentrations and drug permeation of two beta-blockers, propranolol and timolol, in vitro after application to intact skin and skin pretreated with solid MNs of two lengths. Read More
Int J Surg Pathol 2018 Dec 6:1066896918817148. Epub 2018 Dec 6.
1 Istanbul University, Istanbul, Turkey.
In this article, we present a case of anastomosing hemangioma that shows cystic change. The tumor was a unilocular cystic lesion consisting of 2 distinct layers. The inner layer was composed of a proliferation of capillary-sized blood vessels resembling red pulp of the spleen. Read More
Indian J Surg Oncol 2018 Dec 18;9(4):624-628. Epub 2018 May 18.
1Department of Histopathology, Sir Ganga Ram Hospital, Rajender Nagar, New Delhi, India.
Extragonadal germ cell tumors are most commonly encountered in the anterior mediastinum. The presence of sarcomatous malignancies in these tumors is a rare phenomenon that adversely impacts patient prognosis because of poor response to conventional cisplatin-based chemotherapy. Even more unusual is the presence of florid benign somatic proliferations that overshadow the germ cell component, often resulting in misdiagnosis and inappropriate management. Read More
J Cardiol Cases 2014 Jul 17;10(1):16-18. Epub 2014 May 17.
Shahid Beheshti University of Medical Sciences, Iran.
Cardiac hemangiomas account for less than 2% of primary cardiac tumors. They can present with palpitation, arrhythmia, right ventricular outflow tract obstruction, pseudoangina, and in more extreme cases sudden death. Our case report presents a 41-year-old man with atypical chest pain, who had a normal heart examination, electrocardiogram, and an unremarkable family and medical history. Read More
Ophthalmology 2018 Dec 8. Epub 2018 Dec 8.
Memorial Sloan-Kettering Cancer Center, New York, NY; Weill Cornell Medical Center, New York, NY.
Purpose: GNAQ mutations have been identified in port wine stains (both syndromic and non-syndromic) and melanocytic ocular neoplasms. This study investigates the presence of GNAQ mutations in diffuse- (those associated with Sturge-Weber syndrome (SWS)) and solitary choroidal hemangiomas.
Participants: Tissue from 11 patients with the following diagnoses: port wine stain (n = 3), diffuse choroidal hemangioma (n = 1), solitary choroidal hemangioma (n = 6), choroidal nevus (n =1) METHODS: Ten specimens were interrogated with Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT), a hybridization capture-based next-generation sequencing assay for targeted deep sequencing of all exons and selected introns of 468 key cancer genes in formalin-fixed, paraffin-embedded tumors. Read More
Dermatol Ther 2018 Dec 7:e12801. Epub 2018 Dec 7.
Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health.
The field of pediatric dermatology treatment has been rich in new developments. Several recent therapeutic advances in pediatric dermatology have been made. This review will focus on critical approach to the new treatments for several entities encountered in pediatric dermatology. Read More
J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.
Lankenau Institute for Medical Research, Wynnewood, Pennsylvania.
Neovascularization in cancer or retinopathy is driven by pathological changes that foster abnormal sprouting of endothelial cells. Mouse genetic studies indicate that the stress-induced small GTPase RhoB is dispensable for normal physiology but required for pathogenic angiogenesis. In diabetic retinopathy, retinopathy of prematurity (ROP) or age-related wet macular degeneration (AMD), progressive pathologic anatomic changes and ischemia foster neovascularization are characterized by abnormal sprouting of endothelial cells. Read More
Rom J Morphol Embryol 2018 ;59(3):949-953
"Victor Babeş" National Institute for Research and Development in Pathology and Biomedical Sciences, Bucharest, Romania;
Ionizing radiation was used in the past for treatment of several benign cutaneous conditions, and particularly hemangiomas. Even though radiotherapy was generally effective, it significantly augmented the risk for malignancies, resulting in a consequent heavy decline of its use for benign conditions. However, radiation-induced neoplasia is still encountered in adult patients irradiated during childhood or adolescence. Read More
Med Ultrason 2018 Dec;20(4):536-538
Department of Radiology, Interdisciplinary Ultrasound-Center Ludwig-Maximilians-University of Munich - Grosshadern Campus, Munich, Germany.
This case report relates the use of contrast-enhanced ultrasound (CEUS) for the assessment and treatment of a postinterventional cholecystitis, a rare but important complication after transcatheter arterial embolization of a giant hemangioma. Regarding the imaging diagnosis, hemangiomas have specific features allowing a fast recognition by all radiological modalities,and in recent years, especially by CEUS. Read More
Case Rep Urol 2018 6;2018:4259563. Epub 2018 Nov 6.
Urology Department, La Rabta Hospital, Tunis, Tunisia.
Introduction: Paratesticular tumors are rarely observed among scrotal neoplasm. Various types of benign lesions are described. Cavernous hemangioma belongs to uncommon epididymal benign tumors. Read More
Nihon Shokakibyo Gakkai Zasshi 2018 ;115(12):1078-1086
Department of Gastroenterology, Matsushita Memorial Hospital.
We report a rare case of hepatic cholangiolocellular carcinoma (CoCC) with long-term observation. A 73-year-old woman was found to have a solitary hepatic tumor with a diameter of 10mm on dynamic computed tomography (CT), which showed peripheral enhancement in the arterial phase and enhancement retention in the delayed phase. Although it was initially diagnosed as hepatic hemangioma, the follow up examination conducted 16 months later revealed that the tumor had grown to 18mm. Read More
Curr Treat Options Pediatr 2018 Jun 27;4(2):221-236. Epub 2018 Apr 27.
Division of Pediatric Otolaryngology, Department of Surgery, Seattle Children's Hospital and Department of Otolaryngology-Head and Neck Surgery, University of Washington School of Medicine, Seattle, Washington, United States.
Purpose Of Review: This chapter will summarize the most recent literature regarding the current state of medical treatment for vascular anomalies.
Recent Findings: Research into the biology of these anomalies has strengthened our understanding of each anomaly and has helped to pave the way for more tailored treatment options involving molecular and/or genetic targets.
Summary: While there is still a role for surgical intervention, medical therapies that target the etiology of vascular anomalies may represent an alternative or adjunctive approach in the management of these lesions. Read More
J Pak Med Assoc 2018 Dec;68(12):1846-1847
Department of Radiology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
Infantile hepatic hemangioma (IHH) historically called "hemangiomaendothelioma" refers to visceral manifestation of infantile hemangioma. The diagnosis of infantile hepatic hemangioma is primarily based on the radiological features. We present a case of 4 month old infant who presented with abdominal distention. Read More
Am J Med 2018 Nov 29. Epub 2018 Nov 29.
Department of Physiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia, Zip code - 50603. Electronic address:
J Stomatol Oral Maxillofac Surg 2018 Nov 29. Epub 2018 Nov 29.
University of Milan, San Paolo Hospital, Department of Maxillo-Facial Surgery, Via A. DiRudinì 8, 20100, Milan, Italy.
Can J Ophthalmol 2018 Dec 3;53(6):e244-e246. Epub 2018 Apr 3.
Pusan National University School of Medicine, Yangsan, South Korea. Electronic address:
J Coll Physicians Surg Pak 2018 Dec;28(12):970-971
Department of Pathology, Khyber Medical College, Peshawar, Pakistan.
A five-day baby girl presented with a large mass involving the right upper and lower eyelid obstructing the visual axis completely. She was treated with intralesional triamcinolone acetonide injection under general anesthesia but no change in size of the tumor was observed. Oral beta blocker, propranolol, 1 mg/kg body weight, was given at three months. Read More
Einstein (Sao Paulo) 2018 Nov 29;16(4):eRC4509. Epub 2018 Nov 29.
Hospital do Servidor Público Estadual "Francisco Morato de Oliveira, São Paulo, SP, Brazil.
Facial nerve hemangioma is a rare and benign vascular tumor, and accounts for 0.7% of intratemporal tumors. We report the second case described in the literature of a facial nerve hemangioma in its tympanic segment. Read More
Australas J Dermatol 2018 Dec 4. Epub 2018 Dec 4.
Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu, China.
Recently, several studies have reported their experience in using oral atenolol in patients with infantile haemangioma (IH), especially as an alternative to propranolol, but the efficacy and safety of oral atenolol has not been evaluated. We searched PubMed (Medline), Central, Embase, Web of Science and EBSCOhost (until May 2018) for the eligible studies reporting more than 10 IH patients who were treated with oral atenolol with detailed original data, including outcomes, regimens and adverse events (AEs). The data was standardised and analysed by using R software with meta-package. Read More
Radiologia 2018 Dec 1. Epub 2018 Dec 1.
Servicio de Radiología, Hospital Universitari Bellvitge, L'Hospitalet de Llobregat, Barcelona, España.
Medicine (Baltimore) 2018 Nov;97(48):e13448
Istituto di Ricovero e Cura a Carattere Scientifico Centro Neurolesi "Bonino-Pulejo".
Rationale: Myotonic dystrophy type 1 (DM1) is an autosomal dominant disease caused by a cytosine, guanine, thymine (CTG) trinucleotide repeat expansion in the non-coding region of dystrophia myotonica protein kinase gene, causing a multisystem involvement. To date, few studies have been performed to evaluate skin features in DM1 patients, but none reported on the possible association between the disease and tongue hemangiomas.
Patients Concerns: We report a case of a 63-year-old woman affected by DM1 and presenting, at the intraoral examination, several swelling and buish lesions occurring on buccal and palatal mucosa, and in the anterior two-thirds and margins of the tongue. Read More
Colloids Surf B Biointerfaces 2018 Nov 12;174:582-586. Epub 2018 Nov 12.
Department of Food and Drug, Parco Area delle Scienze 27/A, Università di Parma, 43124, Parma, Italy. Electronic address:
Background/aims: Infantile hemangioma (IH), the most common benign tumor of childhood, is currently treated with propranolol. The aim of this work was to study in vitro propranolol permeation and skin retention from an original polymeric film, composed of polyvinyl alcohol and an acrylic polymer.
Methods: Propranolol polymeric films were applied in occlusive and non-occlusive conditions, on either full thickness skin or isolated epidermis. Read More
Intern Emerg Med 2018 Nov 29. Epub 2018 Nov 29.
Digestive Endoscopy Unit, Humanitas Research Hospital, Milan, Italy.
Modern medicine provides almost infinite diagnostic and therapeutic possibilities if compared to the past. As a result, patients undergo a multiplication of tests and therapies, which in turn may trigger further tests, often based on physicians' attitudes or beliefs, which are not always evidence-based. The Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO) adhered to the Choosing Wisely Campaign to promote an informed, evidence-based approach to gastroenterological problems. Read More
Am J Case Rep 2018 Nov 30;19:1425-1429. Epub 2018 Nov 30.
Department of Pathology and Laboratory Medicine, University of Miami, Miami, FL, USA.
BACKGROUND Male breast hemangioma is a rare benign neoplasm that is usually excised for definitive diagnosis. CASE REPORT In our case report, we present a male octogenarian with multiple comorbidities who presented with a large palpable mass in his right breast. The diagnostic imaging studies were suggestive of a benign tumor, with a BI-RADS (Breast Imaging Reporting and Data System) score of 3. Read More
Acta Otorrinolaringol Esp 2018 Nov 26. Epub 2018 Nov 26.
Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Introduction And Objective: Oral benign neoplasms (OBNs) exhibit some features that can guide the professionals to the correct diagnosis and best treatment. Through retrospective studies, medical records can be reviewed to better describe a given population and, furthermore, help clinicians in routine practice. In this context, the objective of this paper was to analyze the cases of OBNs of an oral pathology referral department, from 2003 to 2017, in order to better understand their epidemiological and clinicopathological characteristics. Read More
J Neurosurg 2018 Oct 1:1-9. Epub 2018 Oct 1.
OBJECTIVEVon Hippel-Lindau disease (VHL) is a tumor predisposition syndrome characterized by CNS hemangioblastomas (HBs) and clear cell renal cell carcinomas (RCCs) due to hypoxia-inducible factor activation (pseudohypoxia). Because of the lack of effective medical therapies for VHL, HBs and RCCs account for significant morbidity and mortality, ultimately necessitating numerous neurological and renal surgeries. Propranolol is an FDA-approved pan-beta adrenergic antagonist with antitumor effects against infantile hemangiomas (IHs) and possibly VHL HBs. Read More
Oper Neurosurg (Hagerstown) 2018 Nov 28. Epub 2018 Nov 28.
Department of Neurosurgery, Lenox Hill Hospital, Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.
J Ultrasound 2018 Nov 28. Epub 2018 Nov 28.
Department of Imaging, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Proper nomenclature is a major obstacle in understanding and managing vascular anomalies. Often the same term is used for totally different types of lesions or, conversely, the same lesion may be labeled with different terms. Although in recent times there has been a greater understanding of the problems concerning vascular anomalies, episodes of improper use of terminology still remain. Read More
Contact Dermatitis 2018 Nov 28. Epub 2018 Nov 28.
Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy.
Allergic contact dermatitis (ACD) caused by timolol eyedrops is well-known (1, 2) while ACD following its use for infantile hemangiomas has hitherto not been reported. Read More
Oral Radiol 2018 May 23. Epub 2018 May 23.
Department of Oral and Maxillofacial Radiology and Diagnosis, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi Ward, Yokohama, Kanagawa, 230-8501, Japan.
Objective: Vascular malformations occur more rarely in bones than in soft tissue, with 0.5-1.0% of all intraosseous tumors occurring in the mandible. Read More
Oral Radiol 2018 May 27;34(2):179-184. Epub 2017 Mar 27.
Department of Oral and Maxillofacial Surgery, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, 56000, Kuala Lumpur, Malaysia.
The most conspicuous element of Gorham's disease is its radiographic features, wherein massive disappearance of the mandible is observed. We report a case of an adolescent boy with massive osteolysis of the mandible in whom the diagnosis of Gorham's disease was made. A 14-year-old boy was referred to the Department of Oral and Maxillofacial Surgery, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, for the management of a massive mandibular deformity. Read More
Oral Radiol 2018 Sep 4;34(3):224-228. Epub 2017 Sep 4.
Department of Radiology, The Nippon Dental University Niigata Hospital, 1-8 Hamaura-cho, Chuo-ku, Niigata, Niigata, 951-8580, Japan.
Objectives: The aim of this study was to investigate the usefulness of diffusion-weighted magnetic resonance imaging (DWI) in oral and maxillofacial lesions, especially the utility of apparent diffusion coefficient (ADC) maps for differential diagnosis of these lesions.
Methods: Fifty-seven patients who underwent magnetic resonance imaging for diagnosis of oral and maxillofacial lesions were included in this prospective study. DWI was performed on a 1. Read More
World Neurosurg 2018 Nov 24. Epub 2018 Nov 24.
Fluminense Federal University.
J Int Med Res 2018 Nov 26:300060518809589. Epub 2018 Nov 26.
1 Department of Pathology, Chungbuk National University Hospital, Cheongju, Korea.
Bone hemangioma accounts for approximately 1% of all bone neoplasms and commonly occurs in the vertebral body and skull. However, costal hemangiomas are extremely rare. We herein present a case involving a 52-year-old woman with a hemangioma in the third rib and review 29 cases of rib hemangiomas available in the literature. Read More
J Exp Ther Oncol 2018 Nov;12(4):291-294
MBBS student, Hind Institute of Medical Sciences, Lucknow, U.P, India.
Objective: A telangiectatic granuloma is a localized reactive lesion associated with prolonged irritation to the soft tissues. It may be misdiagnosed as a vascular malformation, hemangiomas, angiosarcomas, etc; as clinical presentation of the lesions resembles each other. Here, we present a case of asymptomatic swelling in the maxilla of a 17-year old female patient. Read More
J Craniofac Surg 2018 Nov 20. Epub 2018 Nov 20.
Division of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital, Kagawa.
Hemangiomas are benign vascular soft tissue tumors, which most frequently occur in the skin or subcutaneous tissue. Intramuscular hemangiomas typically occur in the trunk and extremities and less frequently in the head and neck. Among these, those occurring in the temporalis muscle are extremely rare. Read More
Br J Pharmacol 2018 Nov 24. Epub 2018 Nov 24.
Department of Biology, University of Pisa, Pisa, Italy.
Stress plays a role in tumorigenesis through catecholamines acting at β-adrenoceptors including β1-, β2- and β3-adrenoceptors and the use of β-adrenoceptor antagonists seems to counteract tumor growth and progression. Preclinical evidence and meta-analysis data demonstrate that melanoma shows a positive response to β-adrenoceptor blockers and in particular to propranolol acting mainly at β1- and β2-adrenoceptors. Although evidence suggesting that β3-adrenoceptors may play a role as a therapeutic target in infantile hemangiomas has been recently reviewed, a comprehensive analysis of the available data from preclinical studies supporting a possible role of β3-adrenoceptors in melanoma was not available. Read More
J AAPOS 2018 Nov 20. Epub 2018 Nov 20.
Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address:
Racemose hemangioma is a rare, benign vascular malformation. In the episclera, it appears as dilated, tortuous blood vessels that pass from the fornix over the globe surface to the limbal area, without capillary architecture, and then loop backward into the fornix. Fluorescein angiogram reveals the vascular malformation with rapid flow and confirms the episcleral vessels to be large in caliber and with a curvilinear, twisted configuration. Read More
Arch Plast Surg 2018 Nov 15;45(6):517-524. Epub 2018 Nov 15.
Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Yonsei University College of Medicine, Seoul, Korea.
Background: Infantile hemangioma (IH) is a common vascular tumor in pediatric patients, and is commonly treated with propranolol. We describe our experiences with dosage, response to treatment, and side effects in 23 IH patients treated with propranolol.
Methods: For this nonrandomized comparative cohort study, the authors enrolled 23 patients treated with propranolol. Read More
Indian J Otolaryngol Head Neck Surg 2018 Dec 30;70(4):505-509. Epub 2018 Aug 30.
Department of Otorhinolaryngology, Pt. B.D. Sharma, PGIMS, Rohtak, Haryana India.
Twenty five patients of aural polyp who underwent canal wall down mastoidectomy were analysed retrospectively. Histopathological examination revealed cholesteatoma in 22 (88%) patients. However, histopathological diagnosis in 3 of these patients was unusual and rare benign tumors of the middle ear cleft-meningioma, neurilemmoma and capillary hemangioma. Read More
Asian J Neurosurg 2018 Oct-Dec;13(4):1292-1294
Department of Pathology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.
We report a case of biopsy-proven retrobulbar lymphangioma in a 14-year-old girl. She presented with chief complaints of swelling in the left eye for 2 months. The patient underwent imaging evaluation and it was diagnosed as cavernous hemangioma, radiologically. Read More
Asian J Neurosurg 2018 Oct-Dec;13(4):1222-1224
Department of Neurosurgery, El Manar-Tunis university, Faculty of Medicine of Tunis, National Institute of neurology, Tunis, Tunisia.
Cavernous hemangioma of the orbit (CHO) is a benign slow-growing lesion of intracanal space. Bilateral orbital cavernous hemangiomas are extremely rare, so that only a few cases have been reported in scientific literature. A 54-year-old patient presented a 1-year history of impaired visual acuity of the left eye. Read More
BMC Surg 2018 Nov 20;18(1):103. Epub 2018 Nov 20.
Department of Clinical and Experimental Medicine, Unit of General Surgery 2, University of Sassari, Sassari, Italy.
Background: Adrenal cavernous hemangiomas are very rare benign tumors that usually present as incidental findings on abdominal imaging. Preoperative differential diagnosis from other benign or malignant adrenal neoplasms may be challenging.
Case Presentation: A 70-year old man was referred for an 8-cm abdominal mass incidentally discovered on a contrast-enhanced computed tomography (CT) performed to investigate a pulmonary nodule. Read More
Acta Orthop Belg 2018 Mar;84(1):105-107
We assessed the results of percutaneous vertebroplasty treatment of painful vertebral hemangiomas in 110 patients, with a three years follow-up. 110 patients with painful vertebral hemangiomas were treated by percutaneous vertebroplasty. The patients were diagnosed by MRI and observed for 3 years after surgery. Read More
Eur Radiol 2018 Nov 19. Epub 2018 Nov 19.
Department of Radiology, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul, 110-744, Republic of Korea.
Purpose: To determine the effects of different reconstruction algorithms on histogram and texture features in different targets.
Materials And Methods: Among 3620 patients, 480 had normal liver parenchyma, 494 had focal solid liver lesions (metastases = 259; hepatocellular carcinoma = 99; hemangioma = 78; abscess = 32; and cholangiocarcinoma = 26), and 488 had renal cysts. CT images were reconstructed with filtered back-projection (FBP), hybrid iterative reconstruction (HIR), and iterative model reconstruction (IMR) algorithms. Read More
Pathol Oncol Res 2018 Nov 19. Epub 2018 Nov 19.
Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
Hemangioma is a vascular neoplasm and one of the most common benign tumors. The pathogenesis of hemangioma has not been fully understood. CIZ1 (Cip1-interacting zinc finger protein 1) is a nuclear protein and the binding partner of p21. Read More