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J Neurosci Rural Pract 2019 Apr-Jun;10(2):339-341

Department of Neurosurgery, Kasturba Medical College, Manipal Academy of Higher Education, Mangalore, Karnataka, India.

Cavernomas are vascular malformations which are collections of endothelium-lined sinusoids without intervening cerebral parenchyma. Hypothalamic location of cavernoma is extremely rare. We present a case of a 34-year-old male who presented with complaints of recent memory loss and vomiting. Read More

Klin Monbl Augenheilkd 2019 Apr 18. Epub 2019 Apr 18.

Benign orbital neoplasms comprise a wide spectrum of different entities. The origin of the tumours can be epithelial or mesenchymal. Epithelial neoplasms of the orbit originate from the lacrimal gland. Read More

Am J Case Rep 2019 Apr 16;20:525-530. Epub 2019 Apr 16.

Department of Diagnostic Radiology, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico.

BACKGROUND Intraosseous cavernous skull hemangiomas are rare benign vascular tumors that are usually found incidentally on imaging, with an asymptomatic and slow-growing course. We present a case in which the patient had a mass on her forehead for many years, which began to grow rapidly after head trauma. Imaging characteristics play a crucial role in the diagnosis and description of this disease, and in differentiating it from other more common calvarial lesions that may present with a similar clinical picture. Read More

Endoscopy 2019 Apr 12. Epub 2019 Apr 12.

Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Hawaii J Med Public Health 2019 Apr;78(4):128-131

National Cancer Consortium, Walter Reed National Military Medical Center (WRNMMC), Bethesda, MD (WAK).

The majority of giant hepatic cavernous hemangiomas are asymptomatic and can safely be observed. However, when a lesion becomes symptomatic, affecting quality of life or cannot be distinguished from a malignancy, then operative therapy should be considered. We herein present a case of a symptomatic 12cm × 14cm × 17cm "mega" hemangioma (>10cm) of the left hepatic lobe. Read More

J Fr Ophtalmol 2019 Apr 5. Epub 2019 Apr 5.

Service d'ophtalmologie, université catholique de Lille, groupement des hôpitaux de l'institut catholique de Lille, 59000 Lille, France.

HNO 2019 Apr 2. Epub 2019 Apr 2.

Universitätsklinik Köln, Zentrum für Augenheilkunde, Universität zu Köln, Kerpener Straße 62, 50937, Köln, Deutschland.

Optimal treatment of tumors with orbital invasion may exceed the competences of an individual medical specialty and require interdisciplinary cooperation. The aim of this article is to present an interdisciplinary treatment concept based on the examples of intraorbital hemangioma and squamous cell carcinoma of the paranasal sinuses infiltrating the orbit. In addition to a detailed medical history and a complete ophthalmological examination, a detailed imaging technique with standardized echography and tomography methods such as orbital thin-slice CT and/or in many cases MRI is essential for the primary classification of an intraorbital pathology. Read More

Sci Rep 2019 Mar 22;9(1):5018. Epub 2019 Mar 22.

Department of Urology, Daping Hospital, Army Medical University, Chongqing, China.

To investigate the surgical outcomes of vesiculoscopy on refractory hematospermia and ejaculatory duct obstruction (EDO), the clinical data (including pelvic magnetic resonance imaging (MRI) examinations and the long-term effects of endoscopic treatment) from 305 patients were analyzed. Four main etiologic groups were found on MRI. We found that 62. Read More

Indian J Ophthalmol 2019 Apr;67(4):561-563

Vitreo-Retina and Uvea Services, Sadguru Netra Chikitsalaya, Chitrakoot, Madhya Pradesh, India.

Retinal cavernous hemangiomas is a rare vascular tumor, isolated and non-progressive. This tumor is incidentally diagnosed on fundus examination and visual impairment can be rare presentation from vitreous hemorrhage, pre-retinal traction, hyphema, or macular scarring. The tumor has typical appearance of grape-like clusters of dilated vascular sacs with variable surface gliosis. Read More

J Neuroophthalmol 2019 Mar 18. Epub 2019 Mar 18.

Baylor College of Medicine (GT), Houston, Texas; Department of Ophthalmology (ATK, BAO, AGL), Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas; The Houston Methodist Research Institute (AGL), Houston Methodist Hospital, Houston, Texas; Departments of Ophthalmology, Neurology, and Neurosurgery (AGL), Weill Cornell Medicine, New York, New York; Department of Ophthalmology (AGL), University of Texas Medical Branch, Galveston, Texas; University of Texas MD Anderson Cancer Center (AGL), Houston, Texas; Texas A and M College of Medicine (AGL), Bryan, Texas; and Department of Ophthalmology (AGL), The University of Iowa Hospitals and Clinics, Iowa City, Iowa.

A 30-year-old woman presented with diplopia after resection of an intracranial cavernous malformation. Fundus examination showed an asymptomatic intraocular cavernous hemangioma of the retina. Clinicians should be aware of the potential coexistence of intraocular and intracranial cavernous malformations; the presence of both should suggest familial etiology. Read More

Histopathology 2019 Mar 18. Epub 2019 Mar 18.

Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Spinal hemangiomas, though frequent in the vertebrae, are rare in the spinal canal with only slightly over 100 purely epidural cases reported to date, most of them classified as either cavernous or capillary hemangiomas . Papillary hemangiomas are rare tumors that were previously described as distinctive benign cutaneous lesions that appear as solitary bluish papules in the head and neck . We describe the first report of this neoplasm arising in the spinal canal and discuss the cytogenetic findings of this rare, possibly syndromic, disease entity. Read More

Asian Cardiovasc Thorac Ann 2019 Mar 12:218492319836899. Epub 2019 Mar 12.

1 Cardiothoracic Surgery Division, Department of Surgery, Srinagarind Hospital and Queen Sirikit Heart Center of the Northeast, Faculty of Medicine, Khon Kaen University, Thailand.

Cardiac hemangiomas are extremely rare tumors, especially in infants. We present the case of a 4-month-old girl who developed cyanosis due to a large right atrial tumor causing right ventricular inflow obstruction. The patient underwent emergency surgery for tumor resection and recovered uneventfully. Read More

J Neurosurg 2019 Mar 8:1-6. Epub 2019 Mar 8.

1Department of Neurosurgery, Tufts Medical Center, Boston.

OBJECTIVESurgical resection of sphenoid wing tumors and intraorbital pathology carries the dual goal of appropriately treating the target pathology as well as correcting proptosis. Residual proptosis following surgery can lead to cosmetic and functional disability. The authors sought to quantitatively assess the effect of orbital volume before and after reconstruction to determine the optimal strategy to achieve proptosis correction. Read More

Ann Ital Chir 2019 Feb 26;8. Epub 2019 Feb 26.

Hepatocellular adenomas (HA) are benign naturally occurring masses that are rarely reported, and rarely reaching tumor size up to 30 cm. Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and usually caused by cirrhosis and more commonly reported tumors in males. It has been reported that presentations may occur with masses that are often less than 5 cm or rarely more than 10 cm. Read More

Br J Neurosurg 2019 Mar 4:1-4. Epub 2019 Mar 4.

a Department of Neuroscience, Neurosurgery , AOU Cittá della Salute e della Scienza di Torino , Turin , Italy.

Background: Almost all of the epidural hemangiomas reported are cavernous hemangiomas. Purely extradural spinal capillary hemangiomas are very rare. Capillary hemangiomas are hamartomatous malformations that result from proliferations of vascular endothelial cells. Read More

Int Forum Allergy Rhinol 2019 Feb 27. Epub 2019 Feb 27.

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA.

Background: Orbital cavernous hemangiomas (OCH) are the most common adult orbital tumor and represent an ideal index lesion for endonasal orbital tumor surgery. In order to standardize outcomes reporting, an anatomic-based staging system was developed.

Methods: An international, multidisciplinary panel of 23 experts in orbital tumor surgery was formed. Read More

BMC Cancer 2019 Feb 25;19(1):172. Epub 2019 Feb 25.

Department of Radiotherapy, the Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China.

Background: Primary intraosseous cavernous hemangiomas (PICHs) of the skull are extremely rare. To date, diffuse cranial hemangioma of skull has not been reported. In cancer patients, it is often misdiagnosed as metastasis. Read More

J Clin Ultrasound 2019 Feb 22. Epub 2019 Feb 22.

Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Aneurysm of the inferior vena cava is a rare anomaly with a very few reported cases worldwide. We report the case of a 26-years-old man with acute severe abdominal pain and hypovolemic shock following an episode of syncope. Ultrasonography showed a fusiform aneurysmal dilation of the infra-hepatic inferior vena cava (IVC), with a large saccular portion at its posterolateral wall and mural thrombosis. Read More

Klin Monbl Augenheilkd 2019 Mar 18;236(3):321-339. Epub 2019 Feb 18.

Today, magnetic resonance imaging (MRI) is considered the diagnostic tool of choice for eye and orbital pathologies. In this article, the MR image characteristics of relevant pathologies are illustrated with case-based examples in the context of clinical findings. Vascular pathologies (such as capillary and cavernous hemangioma), inflammatory diseases (such as endocrine orbitopathy), and neoplasms (such as lymphoma, uveal melanoma, retinoblastoma, and ocular/orbital metastasis) are described. Read More

World Neurosurg 2019 Feb 13. Epub 2019 Feb 13.

Department of Biotechnology and Life Sciences; Head and Neck Surgery and Forensic Dissection Research Center; Via Guicciardini, 9, Varese, Italy; Department of Otorhinolaryngology, University of Insubria-Varese, ASST Sette Laghi, Via Guicciardini, 9, Varese, Italy.

Backgrounds: Cryoprobe devices are used by ophthalmic and orbital surgeons for the extraction of fluid-filled intraorbital lesions. No series described cryo-dissection via an exclusive transnasal approach. The authors describe two cases of purely endoscopic transnasal removal of intraconal orbital hemangiomas with the aid of a dedicated cryoprobe. Read More

J Craniomaxillofac Surg 2018 Sep 20. Epub 2018 Sep 20.

University of Parma, Department of Maxillo Facial Surgery (Head: Prof. Enrico Sesenna), Italy.

Vascular malformations are often found inside the orbit. Isolated venous malformations (frequently misnamed as cavernous hemangiomas) are the most frequent among these. However, also lymphatic and arteriovenous malformations can affect the orbit. Read More

Stroke 2019 Mar;50(3):738-744

From the Section of Neurosurgery (R.S., T.M., R.L., R.G., N.H., S.P.P., J.K., D.Z., S.B.L., Y.C., K.C., L.S., I.A.A.), Biological Sciences Division, University of Chicago, IL.

Background and Purpose- Previously, murine models Krit1 Msh2 and Ccm2 Trp53 showed a reduction or no effect on cerebral cavernous malformation (CCM) burden and favorable effects on lesional hemorrhage by the robust Rock (Rho-associated protein kinase) inhibitor fasudil and by simvastatin (a weak pleiotropic inhibitor of Rock). Herein, we concurrently investigated treatment of the more aggressive Pdcd10/Ccm3 model with fasudil, simvastatin, and higher dose atorvastatin to determined effectiveness of Rock inhibition. Methods- The murine models, Pdcd10 Trp53 and Pdcd10 Msh2 , were contemporaneously treated from weaning to 5 months of age with fasudil (100 mg/kg per day in drinking water, n=9), simvastatin (40 mg/kg per day in chow, n=11), atorvastatin (80 mg/kg per day in chow, n=10), or with placebo (n=16). Read More

Cureus 2018 Nov 30;10(11):e3663. Epub 2018 Nov 30.

Neurological Surgery, University of Louisville School of Medicine, Louisville, USA.

Cavernous hemangiomas with an intrasellar extension are very rare, generally benign lesions that manifest by the compression of nearby structures. The presenting symptoms usually range from visual disturbances to an endocrine imbalance. Occasional extension into the cavernous sinus has been reported, which can cause cranial nerve compression. Read More

World Neurosurg 2019 Feb 5. Epub 2019 Feb 5.

Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China.

Background: Cavernous sinus hemangiomas (CSHs) are rare vascular tumors. Stereotactic radiosurgery is an effective treatment for small CSHs. The optimal treatment for giant CSHs is controversial. Read More

J Neurosurg Sci 2019 Feb 4. Epub 2019 Feb 4.

UOC Neurochirurgia, AO San Camillo-Forlanini, Rome, ITALY.

BMC Urol 2019 Jan 31;19(1):13. Epub 2019 Jan 31.

Department of Urology, First Affiliated Hospital of Sun Yat-sen university, Guangzhou, 510080, China.

Background: Diagnosis of urethral cavernous hemangioma (UCH) is very rare. It can be easy to misdiagnose and mistreat due to its atypical clinical manifestations and a lack of relevant knowledge. The study is to explore the diagnosis, differential diagnosis, and treatment of UCH. Read More

J Mol Neurosci 2019 Mar 30;67(3):467-471. Epub 2019 Jan 30.

Department of Neurology, West China Hospital, Sichuan University, Guo Xuexiang #37, Chengdu, 610041, China.

Cerebral cavernous malformation (CCM) is a congenital vascular anomaly that predominantly involves the central nervous system (CNS). CCM occurs in either a sporadic or an inherited form; the latter is called familial cerebral cavernous malformation (FCCM). FCCM has an autosomal dominant transmission with incomplete penetrance and variable clinical expression that is associated with germline mutations in the CCM1/KRIT1, CCM2/MGC4607, and CCM3/PDCD10 genes. Read More

Curr Opin Neurol 2019 Apr;32(2):237-245

Department of Neurology, Jefferson Comprehensive Epilepsy Center.

Purpose Of Review: MRI-guided stereotactic laser interstitial thermal therapy (LiTT) has been utilized in the surgical treatment of discrete, small epileptogenic lesions. This review summarizes the current literature and addresses the clinical application of this technique.

Recent Findings: LiTT has the potential to reduce the morbidity and discomfort of epilepsy surgery. Read More

Fetal Pediatr Pathol 2019 Feb 19;38(1):85-90. Epub 2019 Jan 19.

c Department of Gyneco-Obstetrics, Hospital Habib Bougatfa, Faculty of Medicine of Tunis, University of Tunis El Manar , Tunis , Tunisia.

Background: Congenital cutaneous hemangioma is a benign vascular lesion that is a leading cause of severe hemodynamic compromise in a fetus when it is of significant size and especially in association with arteriovenous malformation.

Case Report: A large cutaneous hemangioma involving the right arm of a 32-week-old male fetus was complicated by fetal hypotrophy, hydrops fetalis and neonatal death. Axillary arteriovenous fistulas and bilateral arterial carotid-subclavian anastomosis were demonstrated at autopsy. Read More

Acta Cardiol 2019 Jan 16:1-2. Epub 2019 Jan 16.

c Department of Thoracic and Vascular Surgery , Antwerp University Hospital , Edegem (Antwerp) , Belgium.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Nov;43(11):1246-1250

Department of Geriatrics Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To determine the etiologies and risk factors of intracerebral hemorrhage in young people.
 Methods: A total of 401 young patients with intracerebral hemorrhage were enrolled, and they were assigned into a 20-29 , a 30-39, and a 40-45 age group. The differences of various etiologies and risk factors among the three groups were analyzed. Read More

J Clin Neurosci 2019 Apr 4;62:231-234. Epub 2019 Jan 4.

LINT, Facultad de Medicina, Universidad Nacional de Tucumán, Tucumán, Argentina; Chief of Department of Neurological Surgery, Hospital Padilla, Tucumán, Argentina.

A case is reported of a 19-year old patient with a supratentorial giant cavernous malformation (GCM). This was an incidental finding in the context of acute head trauma. Brain computed tomography (CT) scan and magnetic resonance imaging (MRI) revealed a giant supratentorial right mass. Read More

Br J Ophthalmol 2019 Jan 5. Epub 2019 Jan 5.

Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

Purpose: To evaluate the efficacy and safety of multisession gamma knife radiosurgery (GKRS) for orbital apex venous cavernous malformation causing optic neuropathy.

Methods: Retrospective cohort study in a single tertiary institution from January 2007 to December 2016 on patients who underwent multisession GKRS for orbital apex venous cavernous malformations causing optic neuropathy.

Results: There were 12 patients included in our study. Read More

Am Surg 2018 Dec;84(12):e524-e526

World J Gastrointest Oncol 2018 Dec;10(12):516-521

Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.

Background: Hemangioma of the small intestine is a rare vascular malformation. Before the advent of capsule endoscopy (CE) and balloon-assisted enteroscopy (BAE), preoperative diagnosis of this disease was extremely difficult.

Case Summary: In this study, we report a 24-year-old female with a large transmural small bowel cavernous hemangioma, which was diagnosed with CE and BAE preoperatively and removed successfully using minimally invasive surgery. Read More

Urol Case Rep 2019 Mar 15;23:52-54. Epub 2018 Dec 15.

Division of Urology, Department of Surgery, Faculty of Medicine, Universitas Udayana/Sanglah Hospital, Bali, Indonesia.

Urinary hemangiomas are uncommon and can predispose any part of the urinary system. The urethra is infrequently involved and usually affected male urethra. We reported a sixty-three-year-old female patient with intermittent urethral bleeding due to tumor arising at the edge of the urethra. Read More

World Neurosurg 2019 Mar 22;123:371-377. Epub 2018 Dec 22.

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People's Republic of China. Electronic address:

Objective: This meta-analysis is to evaluate the clinical efficacy of gamma knife radiosurgery (GKRS) for treating cavernous malformations.

Methods: PubMed, Ovid Embase, and Ovid Medline electronic databases were searched. The primary outcome is hemorrhage rate and this meta-analysis is performed. Read More

CASE (Phila) 2018 Dec 22;2(6):262-265. Epub 2018 Sep 22.

Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire.

Medicine (Baltimore) 2018 Dec;97(51):e13509

Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University.

Rationale: Cavernous hemangiomas are benign vascular malformations that usually involve the skin, subcutaneous tissue, and liver. Described herein was multiple masses in the lung and liver mimicking metastasis, which was proved to be cavernous hemangiomas histologically.

Patient Concerns: A 78-year-old man with complaint of dizziness for 3 days was referred to the local hospital for medical attention. Read More

Int J Surg Case Rep 2018 24;53:479-482. Epub 2018 Nov 24.

Department of Urology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430079, PR China. Electronic address:

Introduction: Hemangiomas are benign tumor formations of capillaries and blood vessels which are commonly found in various organs. However they are extremely rare in urinary bladder accounting for only 0.6% of all urinary bladder tumors. Read More

J Clin Exp Hepatol 2018 Dec 19;8(4):474-477. Epub 2018 Jul 19.

Icahn School of Medicine at Mount Sinai, Department of Pathology New York, NY, USA 10029-6574.

Sclerosing hemangiomas of the liver are rare benign tumors of the liver. Although hepatic hemangiomas are the most common benign liver tumor, they are mostly cavernous in nature. A hepatic sclerosing hemangioma is defined by presence of fibrosis and hyalinization as a result of degenerative changes in a cavernous hemangioma. Read More

Neurol Sci 2019 Feb 6;40(2):243-251. Epub 2018 Dec 6.

Department of Biomedical and Dental Science and Morphological and Functional Images, University of Messina, Consolare Valeria street 1, 98125, Messina, Italy.

Cerebrovascular malformations include a wide range of blood vessel disorders affecting brain vasculature. Neuroimaging differential diagnosis can result unspecific due to similar phenotypes of lesions and their deep localization. Next-generation sequencing (NGS) platforms simultaneously analyze several hundreds of genes and can be applied for molecular distinction of different phenotypes within the same disorder's macro-area. Read More

Case Rep Urol 2018 6;2018:4259563. Epub 2018 Nov 6.

Urology Department, La Rabta Hospital, Tunis, Tunisia.

Introduction: Paratesticular tumors are rarely observed among scrotal neoplasm. Various types of benign lesions are described. Cavernous hemangioma belongs to uncommon epididymal benign tumors. Read More

Medicine (Baltimore) 2018 Nov;97(48):e13448

Istituto di Ricovero e Cura a Carattere Scientifico Centro Neurolesi "Bonino-Pulejo".

Rationale: Myotonic dystrophy type 1 (DM1) is an autosomal dominant disease caused by a cytosine, guanine, thymine (CTG) trinucleotide repeat expansion in the non-coding region of dystrophia myotonica protein kinase gene, causing a multisystem involvement. To date, few studies have been performed to evaluate skin features in DM1 patients, but none reported on the possible association between the disease and tongue hemangiomas.

Patients Concerns: We report a case of a 63-year-old woman affected by DM1 and presenting, at the intraoral examination, several swelling and buish lesions occurring on buccal and palatal mucosa, and in the anterior two-thirds and margins of the tongue. Read More

Oper Neurosurg (Hagerstown) 2019 May;16(5):E146-E147

Department of Neurosurgery, Lenox Hill Hospital, Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.

Oral Radiol 2019 May 23;35(2):194-197. Epub 2018 May 23.

Department of Oral and Maxillofacial Radiology and Diagnosis, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi Ward, Yokohama, Kanagawa, 230-8501, Japan.

Objective: Vascular malformations occur more rarely in bones than in soft tissue, with 0.5-1.0% of all intraosseous tumors occurring in the mandible. Read More

World Neurosurg 2019 Mar 24;123:156. Epub 2018 Nov 24.

Fluminense Federal University, Rio de Janerio, Brazil.

Resection of lesions in the cavernous sinus remains a challenge to neurosurgeons due to its complex anatomy. This video (Video 1) presents the most relevant landmarks of the cavernous sinus region, helping to understand the surgical anatomy. A 55-year-old female presented with diplopia, partial ptosis, and facial dysesthesia in the left ophthalmic territory. Read More

J Craniofac Surg 2019 Jan;30(1):193-195

Division of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital, Kagawa.

Hemangiomas are benign vascular soft tissue tumors, which most frequently occur in the skin or subcutaneous tissue. Intramuscular hemangiomas typically occur in the trunk and extremities and less frequently in the head and neck. Among these, those occurring in the temporalis muscle are extremely rare. Read More

Asian J Neurosurg 2018 Oct-Dec;13(4):1292-1294

Department of Pathology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.

We report a case of biopsy-proven retrobulbar lymphangioma in a 14-year-old girl. She presented with chief complaints of swelling in the left eye for 2 months. The patient underwent imaging evaluation and it was diagnosed as cavernous hemangioma, radiologically. Read More

Asian J Neurosurg 2018 Oct-Dec;13(4):1222-1224

Department of Neurosurgery, El Manar-Tunis university, Faculty of Medicine of Tunis, National Institute of neurology, Tunis, Tunisia.

Cavernous hemangioma of the orbit (CHO) is a benign slow-growing lesion of intracanal space. Bilateral orbital cavernous hemangiomas are extremely rare, so that only a few cases have been reported in scientific literature. A 54-year-old patient presented a 1-year history of impaired visual acuity of the left eye. Read More