Search Our Scientific Publications & Authors

J Craniofac Surg 2022 Jun 27. Epub 2022 Jun 27.

First Department, Removable Prosthodontics, Faculty of Dental Medicine, UMF Carol Davila, Bucharest, Romania.

Due to high energy content and specific characteristics of dental laser light, this kind of procedure optimizes the outcome on oral cavernous hemangioma removal, diminishing the risks, and complications. Management of a very rare internal cheek cavernous hemangioma presenting a high risk of injury in a patient with chronic acenocoumarol medication and high blood pressure, can be accomplished using diode 810nm laser, in the dental office with predictable results. Protocol complied diode laser, with specific fiber tip, specific power, and operation mode, for 1 minute/1 cm2 irradiated area. Read More

Genes (Basel) 2022 May 27;13(6). Epub 2022 May 27.

Division of Medical Genetics, Fondazione IRCCS-Casa Sollievo della Sofferenza, 71013 Foggia, Italy.

Cerebral cavernous malformations (CCM) are capillary malformations affecting the central nervous system and commonly present with headaches, epilepsy and stroke. Treatment of CCM is symptomatic, and its prevention is limited. CCM are often sporadic but sometimes may be multifocal and/or affect multiple family members. Read More

Oper Neurosurg (Hagerstown) 2022 Jul 20;23(1):e66. Epub 2022 Apr 20.

Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.

STAR Protoc 2022 Jun 9;3(2):101448. Epub 2022 Jun 9.

Vascular Biology Unit, The FIRC Institute of Molecular Oncology Foundation, Milan 20139, Italy.

In the study of cerebral cavernous malformations (CCMs), the quantification of lesion burden is the main parameter for evaluation of disease severity and efficacy of drugs. We describe a reliable and cost-effective protocol to evaluate the number and the size of vascular malformations in the murine brain. This approach is based on histology and confocal imaging and can be performed with standard laboratory equipment. Read More

J Gastrointest Surg 2022 Jun 15. Epub 2022 Jun 15.

Department of Surgery, The Ohio State University Wexner Medical Center, 395 W. 12th Ave., Suite 670, Columbus, OH, USA.

Background: Hepatic hemangiomas (HHs) are benign liver lesions often discovered incidentally on imaging for various unrelated pathologies. We herein review the etiology, classification, diagnostic imaging, and management of HHs.

Methods: A comprehensive systematic review was performed utilizing MEDLINE/PubMed and Web of Science databases, with the end of search date being March 1, 2022, regarding HH diagnosis, imaging, and management. Read More

Front Oncol 2022 26;12:865865. Epub 2022 May 26.

Department of Neurosurgery, Tangdu Hospital, Air Force Medical University, Xi'an, China.

Objective: To improve the diagnosis and treatment of intracranial chondromas (ICDs) by discussing the clinical manifestations and imaging characteristics of ICDs, as well as surgical methods and treatment strategies.

Methods: We retrospectively analyzed 17 patients diagnosed with ICDs who underwent microsurgery or endoscopic transsphenoidal surgery at the Tangdu Hospital of Air Force Military Medical University and the Mianyang Central Hospital from January 2010 to November 2021. Clinical manifestations, imaging examinations, surgical treatments, and prognosis of these patients were analyzed. Read More

BMJ Case Rep 2022 Jun 10;15(6). Epub 2022 Jun 10.

Surgical Oncology, University of Rochester Wilmot Cancer Institute, Rochester, New York, USA

Hepatic cavernous haemangioma is a benign tumour of vascular origin found within the liver. Often incidentally diagnosed, the management of these vascular masses is frequently determined by the size of the mass and symptoms associated with its compression of adjacent structures. Tumours >10 cm are known as giant haemangiomas and are associated with increased risks of compression symptoms, coagulopathies and haemorrhage. Read More

J Surg Case Rep 2022 May 27;2022(5):rjac242. Epub 2022 May 27.

Department of Otolaryngology-Head and Neck Surgery, Daejeon Eulji Medical Center, Eulji University School of Medicine, Daejeon, Republic of Korea.

Cavernous hemangioma of the external auditory canal (EAC) is a rare clinical finding. Endoscopic ear surgery has been successfully applied for various ear pathologies with a wider surgical sight, minimal canal cuts and precise manipulation of soft tissues. We report a case of a 60-year-old woman with hemangioma of EAC which increased in size without treatment for several years. Read More

Clin Case Rep 2022 May 27;10(5):e05905. Epub 2022 May 27.

Hospital for Advanced Medicine and Surgery Kathmandu Nepal.

We present a rare case of a 45-year-old man with abdominal pain and features suggestive of intestinal obstruction. The CT scan of the abdomen demonstrated a large mesenteric mass involving the distal segment of jejunum. Surgical excision of the lesion and histopathological examination revealed the diagnosis of cavernous hemangioma. Read More

Cureus 2022 Apr 30;14(4):e24622. Epub 2022 Apr 30.

Pathology, Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry, IND.

A primary cardiac tumor is sporadic. Most cardiac tumors are benign, with cardiac myxoma being the most common tumor. The incidence of cardiac hemangioma is extremely low. Read More

Cell Mol Life Sci 2022 Jun 4;79(6):340. Epub 2022 Jun 4.

Department of Human Genetics, University Medicine Greifswald and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Fleischmannstraße 43, 17475, Greifswald, Germany.

Cerebral cavernous malformations (CCM) are low-flow vascular lesions prone to cause severe hemorrhage-associated neurological complications. Pathogenic germline variants in CCM1, CCM2, or CCM3 can be identified in nearly 100% of CCM patients with a positive family history. In line with the concept that tumor-like mechanisms are involved in CCM formation and growth, we here demonstrate an abnormally increased proliferation rate of CCM3-deficient endothelial cells in co-culture with wild-type cells and in mosaic human iPSC-derived vascular organoids. Read More

Curr Med Imaging 2022 Jun 2. Epub 2022 Jun 2.

Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Objectives: This study aimed to clarify features of giant cavernous hemangioma (GCH) and liver hemangiomatosis existing simultaneously on gadolinium-ethoxybenzyl-diethylenetriamin pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI).

Methods: A total of 17 patients with reported hepatic hemangiomatosis between 2015 and 2017 were identified retrospectively. All our patients underwent pre-contrast MRI, triphasic (atrial, portal, venous) Gd-EOB-DTPA dynamic enhancement and hepatobiliary phase (20 minutes delayed). Read More

World Neurosurg 2022 May 30;164:323-329. Epub 2022 May 30.

Department of Neurosurgery, "Attikon" University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Primary intraosseous cavernous hemangioma (PICH) is a rare, benign tumor of vascular origin, typically arising in the vertebral body. Its presence in the skull is exceedingly rare, with only a few cases being reported worldwide. We carried out the first systematic review of the literature, covering the epidemiology, clinical and imaging features, management, and prognosis of cranial PICH. Read More

Acta Neuropathol Commun 2022 May 31;10(1):81. Epub 2022 May 31.

Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.

The International Society for the Study of Vascular Anomalies (ISSVA) has defined four vascular lesions in the central nervous system (CNS): arteriovenous malformations, cavernous angiomas (also known as cerebral cavernous malformations), venous malformations, and telangiectasias. From a retrospective central radiological and histopathological review of 202 CNS vascular lesions, we identified three cases of unclassified vascular lesions. Interestingly, they shared the same radiological and histopathological features evoking the cavernous subtype of angioleiomyomas described in the soft tissue. Read More

World J Otorhinolaryngol Head Neck Surg 2022 Mar 31;8(1):25-35. Epub 2022 Mar 31.

Division of Rhinology and Endoscopic Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery University of Washington Seattle Washington USA.

Objective: As exclusively endoscopic endonasal resection of benign orbital tumors has become more widespread, high-quality outcomes data are lacking regarding the decision of when and how to reconstruct the medial orbital wall following resection. The goal of this study was to systematically review pertinent literature to assess clinical outcomes relative to orbital reconstruction practices.

Methods: Data Sources: PubMed, EMBASE, Web of Science. Read More

Clin Case Rep 2022 May 16;10(5):e05875. Epub 2022 May 16.

Faculty of Medicine Mbarara University of Science and Technology Mbarara Uganda.

Cavernous hemangioma (CH) of urinary bladder occurs relatively infrequently, accounting for 0.6% of all bladder tumors. This tumor may occur sporadically or coexist with other benign and malignant vascular lesions. Read More

J Surg Case Rep 2022 May 18;2022(5):rjac230. Epub 2022 May 18.

Division of Cardiothoracic Surgery, The DeWitt Daughtry Department of Surgery, University of Miami, Miami, FL, USA.

Benign vascular tumors of the mediastinum are rare, representing only 0.5% of all mediastinal masses. Given their rare presentation, they are infrequently considered in the workup of a middle mediastinal mass. Read More

Clin Case Rep 2022 May 12;10(5):e05850. Epub 2022 May 12.

Departement of General Surgery Internal Security Forces Hospital Marsa Tunisia.

Primary retroperitoneal cavernous hemangioma is an extremely rare disease in clinical practice. It is classified as a vascular tumor. Only three cases have been reported in the literature. Read More

Eur J Cardiothorac Surg 2022 May 19. Epub 2022 May 19.

Department of Cardiac Surgery, Wuhan Asia Heart Hospital, Wuhan, P.R. China.

J Belg Soc Radiol 2022 25;106(1):17. Epub 2022 Apr 25.

Ibn Sina Teaching hospital, MA.

Although frequent, the coexistence of diffuse hepatic hemangiomatosis (DHH) with giant cavernous hemangioma (GCH) should be mentioned clearly and communicated to the referring physician for an appropriate management. Read More

Int J Mol Sci 2022 Apr 30;23(9). Epub 2022 Apr 30.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Cerebral cavernous malformation (CCM) is a cerebromicrovascular disease that affects up to 0.5% of the population. Vessel dilation, decreased endothelial cell-cell contact, and loss of junctional complexes lead to loss of brain endothelial barrier integrity and hemorrhagic lesion formation. Read More

J Gastrointest Oncol 2022 Apr;13(2):787-791

Department of Interventional Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.

Background: Computed tomography (CT) is a common imaging technique for diagnosis of liver tumors. However, the intensity similarity on non-contrast CT images is small, making it difficult for radiologists to visually identify hepatic cavernous hemangioma (HCH) and hepatocellular carcinoma (HCC). Recently, convolutional neural networks (CNN) have been widely used in the study of medical image classification because more discriminative image features can be extracted than the human eye. Read More

Front Med (Lausanne) 2022 25;9:872824. Epub 2022 Apr 25.

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.

Background: Surgery is the mainstay treatment for patients with symptomatic intramedullary spinal cavernous hemangioma (ISCH), however the time of surgical intervention remains controversial. In this study, we proposed emergency rescue surgery (ERS) for patients in deteriorative type. The prognostic factors of patients with ISCH after microsurgery and the clinical effect of ERS were analyzed. Read More

Abdom Radiol (NY) 2022 Jul 10;47(7):2453-2461. Epub 2022 May 10.

Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, 1053 Carling Avenue, C1 Radiology, Ottawa, ON, K1Y 4E9, Canada.

Objective: To compare diagnostic accuracy of washout (WO)-CT to chemical shift (CS)-MRI + T2W adrenal MRI Calculator (T2W-Calculator) to diagnose adrenal adenoma in indeterminate adrenal masses.

Methods: This retrospective, cross-sectional, non-inferiority study evaluated 40 consecutive indeterminate adrenal masses; each with WO-CT and MRI. Two blinded radiologists independently evaluated in mixed order: pre-contrast attenuation (Hounsfield Units, HU) and absolute WO ([Peak. Read More

J Neurosurg 2022 Apr 29:1-9. Epub 2022 Apr 29.

Objective: Giant cerebral cavernous malformations (GCCMs) are rare vascular malformations. Unlike for tumors and aneurysms, there is no clear definition of a "giant" cavernous malformation (CM). As a result of variable definitions, working descriptions and outcome data of patients with GCCM are unclear. Read More

Neurol India 2022 Mar-Apr;70(2):822-823

Departments of Neurological Surgery, Juntendo University Urayasu Hospital, Urayasu, Chiba.

Neurol India 2022 Mar-Apr;70(2):563-573

Department of Neurosurgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Background: The challenges associated with surgeries of cavernous sinus (CS) lesions have shifted the management trend towards upfront gamma knife radiosurgery (GKRS). Although GKRS is effective in arresting the progression of certain small residual/recurrent lesions, its efficacy in alleviating neurological deficits is less evident. Furthermore, GKRS without establishing the histopathological diagnosis, at times can be detrimental. Read More

J Radiol Case Rep 2022 Mar 1;16(3):15-22. Epub 2022 Mar 1.

Anatomical Pathology Department, Faculty of Medicine, Universitas Airlangga, Indonesia.

Intramedullary cavernous angioma is a rare vascular malformation compared to cerebral cavernous malformation. The incidence of cavernous angioma is about 3 - 5% of all central nervous system lesions, 5 - 12% of all spinal vascular lesions, and 1% of all intramedullary lesions in pediatric patients. Although intramedullary cavernous angioma has the same histological picture as cerebral cavernous angioma, the natural history, and surgical approach are different from cerebral cavernous angioma. Read More

Neurocirugia (Astur : Engl Ed) 2022 May-Jun;33(3):135-140

Department of Neurosurgery, 401 General Military Hospital of Athens, Kanellopoulou & Mesogeion Avenue, 11527 Athens, Greece.

Skull vault hemangiomas are benign vascular tumours of the calvaria that are usually asymptomatic or present as firm, painless lumps. We present a case of a 59-year-old female with a giant intraosseous calvarial hemangioma that was admitted in our department with a palpable mass over the left frontoparietal region, personality changes and impaired emotional and cognitive functions. The patient was treated with a two-step approach involving endovascular and surgical treatment, and suffered two rare, but recognized complications, a contrecoup intracerebral haemorrhage and valproate-induced stupor and parkinsonism. Read More

Surg Neurol Int 2022 31;13:123. Epub 2022 Mar 31.

Department of Neurosurgery, Sapienza University of Rome, Rome, Italy.

Background: Cavernous angiomas, also referred to as cavernous hemangiomas or cavernomas (CMs), are vascular malformative benign neoplasms that may develop in any part of the central nervous system. Spinal CMs are uncommon (overall incidence rate of 0.04-0. Read More