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Asian Cardiovasc Thorac Ann 2019 Mar 12:218492319836899. Epub 2019 Mar 12.

1 Cardiothoracic Surgery Division, Department of Surgery, Srinagarind Hospital and Queen Sirikit Heart Center of the Northeast, Faculty of Medicine, Khon Kaen University, Thailand.

Cardiac hemangiomas are extremely rare tumors, especially in infants. We present the case of a 4-month-old girl who developed cyanosis due to a large right atrial tumor causing right ventricular inflow obstruction. The patient underwent emergency surgery for tumor resection and recovered uneventfully. Read More

Cureus 2018 Dec 27;10(12):e3784. Epub 2018 Dec 27.

Radiology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, USA.

An intraneural hemangioma is a rare, benign mesodermal lesion. We present a case of a three-year-old female with the inability to straighten her right knee and fullness over the right popliteal fossa for one year. Magnetic resonance imaging (MRI) demonstrated a T2 hyperintense lesion of the popliteal fossa, within the tibial nerve. Read More

BMJ Case Rep 2019 Mar 8;12(3). Epub 2019 Mar 8.

Department of General Surgery, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

Parkes Weber syndrome (PWS) is a rare disorder characterised by arteriovenous (AV) fistula, along with capillary, lymphatic, venous malformations and limb hypertrophy. Stewart-Bluefarb syndrome is a variant of acroangiodermatitis, which is associated with congenital AV malformation/fistulas. It usually begins early in life, unilaterally over lower extremities presenting as violaceous to dusky coloured macules, papules or plaques with tendency to ulcerate. Read More

Arch Bronconeumol 2019 Mar 5. Epub 2019 Mar 5.

Servicio de Anatomía Patológica, Hospital Clínico Universitario de Valladolid, Valladolid, España; Centro de Investigación en Red Enfermedades Respiratorias (CIBERES).

Ophthalmic Plast Reconstr Surg 2019 Mar 4. Epub 2019 Mar 4.

Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: To evaluate the clinical and ultrasonographic response of periocular infantile capillary hemangioma during treatment with oral propranolol.

Methods: Patients with infantile periocular hemangioma and visual or cosmetic concerns were enrolled in this prospective interventional case series. Propranolol was given at a dose of 2 mg/kg per day for at least 6 months. Read More

Br J Neurosurg 2019 Mar 4:1-4. Epub 2019 Mar 4.

a Department of Neuroscience, Neurosurgery , AOU Cittá della Salute e della Scienza di Torino , Turin , Italy.

Background: Almost all of the epidural hemangiomas reported are cavernous hemangiomas. Purely extradural spinal capillary hemangiomas are very rare. Capillary hemangiomas are hamartomatous malformations that result from proliferations of vascular endothelial cells. Read More

Klin Monbl Augenheilkd 2019 Feb 18. Epub 2019 Feb 18.

Today, magnetic resonance imaging (MRI) is considered the diagnostic tool of choice for eye and orbital pathologies. In this article, the MR image characteristics of relevant pathologies are illustrated with case-based examples in the context of clinical findings. Vascular pathologies (such as capillary and cavernous hemangioma), inflammatory diseases (such as endocrine orbitopathy), and neoplasms (such as lymphoma, uveal melanoma, retinoblastoma, and ocular/orbital metastasis) are described. Read More

Surv Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Department of Ophthalmology, University of Washington, WA, USA; Department of Oculoplastic and Reconstructive Surgery, University of Washington, WA, USA. Electronic address:

Infantile hemangiomas (IHs), otherwise known as infantile capillary hemangiomas, strawberry hemangiomas, or strawberry nevi, are non-malignant vascular tumors that commonly affect children. The natural disease course typically involves growth for up to a year followed by regression without treatment over a period of years, with no cosmetic or functional sequelae. Less commonly, however, IHs can become a threat to vision or even life depending on location and size of the lesion. Read More

World Neurosurg 2019 Jan 24. Epub 2019 Jan 24.

Director and Head, Department of Radiology, Fortis Memorial Research Institute, Gurugram, Haryana-122003. Electronic address:

Fetal Pediatr Pathol 2019 Jan 24:1-7. Epub 2019 Jan 24.

a Pathology, DISC , University of Genoa , Genoa , Italy.

Introduction: Hepatic hemangiomas (HH) are benign vascular tumors, and when large, may contribute to fetal morbidity/mortality. Chorangiosis is placental villus capillary hypervascularity, probably linked with fetal hypoxia.

Case Report: We present a macrosomic stillbirth at 39 + 3 weeks of gestation with congestive heart failure (CHF) and myocardial infarction. Read More

Eplasty 2019 7;19:ic1. Epub 2019 Jan 7.

Department of Plastic Surgery, Morsani College of Medicine, Tampa, Fla.

J Cutan Pathol 2019 Jan 21. Epub 2019 Jan 21.

Departments of Pathology/Microbiology, Pediatrics and Orthopaedic Surgery, Nebraska Medical Center, Omaha, Nebraska.

Anastomosing hemangioma (AH) is a relatively novel variant of benign vascular tumors originally described in the genitourinary tract. Although AH was subsequently documented in various anatomic locations, a primary AH of the skin has not been reported in the literature. The current case report documents a vascular lesion with histologic features reminiscent of an AH. Read More

Fetal Pediatr Pathol 2019 Jan 19:1-6. Epub 2019 Jan 19.

c Department of Gyneco-Obstetrics, Hospital Habib Bougatfa, Faculty of Medicine of Tunis, University of Tunis El Manar , Tunis , Tunisia.

Background: Congenital cutaneous hemangioma is a benign vascular lesion that is a leading cause of severe hemodynamic compromise in a fetus when it is of significant size and especially in association with arteriovenous malformation.

Case Report: A large cutaneous hemangioma involving the right arm of a 32-week-old male fetus was complicated by fetal hypotrophy, hydrops fetalis and neonatal death. Axillary arteriovenous fistulas and bilateral arterial carotid-subclavian anastomosis were demonstrated at autopsy. Read More

World Neurosurg 2019 Jan 16. Epub 2019 Jan 16.

Department of Neurosurgery, King's College Hospital, London.

Background: Capillary haemangiomata are benign vascular tumours that typically occur in children. They rarely occur in the central nervous system. Intracranial capillary haemangioma in adults are very rare entities with only 18 cases reported in the literature. Read More

J Dermatol 2019 Jan 10. Epub 2019 Jan 10.

National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

J Dermatol 2019 Mar 28;46(3):245-248. Epub 2018 Dec 28.

Pediatric Dermatology Unit, Dana Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Pyogenic granuloma is a benign acquired vascular tumor that affects the skin and mucous membranes, occurring more often in children and young adults. Treatment is often required due to the associated risk of ulceration and bleeding. There are several publications reporting the use of beta-blockers for the treatment of pyogenic granuloma. Read More

In Vivo 2019 Jan-Feb;33(1):251-254

Department of Pathology, Immunology and Laboratory of Medicine, University of Florida College of Medicine, Gainesville, FL, U.S.A.

Pyogenic granuloma (PG) represents a lobular capillary proliferation commonly seen in the skin or oral mucosa. They are rarely reported in the gastrointestinal tract. The mechanism underlying PG pathogenesis is not well understood. Read More

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Neonatology, University of Washington, Seattle, Washington, USA.

A premature twin infant girl was transferred to a level IV neonatal intensive care unit for recurrent bloody stools, anaemia and discomfort with feeds; without radiographic evidence of necrotising enterocolitis. Additional imaging after transfer revealed a large retroperitoneal mass in the region of the pancreas compressing the inferior vena cava and abdominal aorta, raising suspicion for neuroblastoma. Abdominal exploration and biopsy unexpectedly revealed that the lesion was an infantile capillary haemangioma involving the small bowel, omentum, mesentery and pancreas. Read More

Int J Surg Case Rep 2018 24;53:479-482. Epub 2018 Nov 24.

Department of Urology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430079, PR China. Electronic address:

Introduction: Hemangiomas are benign tumor formations of capillaries and blood vessels which are commonly found in various organs. However they are extremely rare in urinary bladder accounting for only 0.6% of all urinary bladder tumors. Read More

MAbs 2019 Jan 12;11(1):26-44. Epub 2018 Dec 12.

a UltraHuman Limited, Codebase , Edinburgh , UK.

Monoclonal anti-programmed cell death 1 (PD1) antibodies are successful cancer therapeutics, but it is not well understood why individual antibodies should have idiosyncratic side-effects. As the humanized antibody SHR-1210 causes capillary hemangioma in patients, a unique toxicity amongst anti-PD1 antibodies, we performed human receptor proteome screening to identify nonspecific interactions that might drive angiogenesis. This screen identified that SHR-1210 mediated aberrant, but highly selective, low affinity binding to human receptors such as vascular endothelial growth factor receptor 2 (VEGFR2), frizzled class receptor 5 and UL16 binding protein 2 (ULBP2). Read More

Int J Surg Pathol 2018 Dec 6:1066896918817148. Epub 2018 Dec 6.

1 Istanbul University, Istanbul, Turkey.

In this article, we present a case of anastomosing hemangioma that shows cystic change. The tumor was a unilocular cystic lesion consisting of 2 distinct layers. The inner layer was composed of a proliferation of capillary-sized blood vessels resembling red pulp of the spleen. Read More

J Coll Physicians Surg Pak 2018 Dec;28(12):970-971

Department of Pathology, Khyber Medical College, Peshawar, Pakistan.

A five-day baby girl presented with a large mass involving the right upper and lower eyelid obstructing the visual axis completely. She was treated with intralesional triamcinolone acetonide injection under general anesthesia but no change in size of the tumor was observed. Oral beta blocker, propranolol, 1 mg/kg body weight, was given at three months. Read More

J Vet Intern Med 2019 Jan 29;33(1):114-123. Epub 2018 Nov 29.

Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan.

Background: Histologic features of pulmonary veno-occlusive disease (PVOD) and pulmonary capillary hemangiomatosis (PCH) have been described in dogs but without a thorough clinical description.

Objectives: To report the clinical features, diagnostics, treatment, and outcome of dogs with histologic evidence of PVOD and PCH.

Animals: Fifteen pet dogs meeting histopathologic criteria of PVOD (occlusive remodeling of small-sized to medium-sized pulmonary veins) or PCH (alveolar capillary proliferation and congestion), or both. Read More

Ophthalmic Res 2019 29;61(2):115-119. Epub 2018 Nov 29.

Retina and Uvea Services, Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi,

Retinal angiomas are rare tumors that develop within the vascular bed of the retina. Their occurrence may be sporadic or as part of the multisystem disorder called von Hippel-Lindau disease. It is well established in literature that retinal angiomas have a natural history of evolving as small aneurysmal dilatations and progressing to vision-threatening retinal detachments. Read More

J AAPOS 2018 Nov 20. Epub 2018 Nov 20.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address:

Racemose hemangioma is a rare, benign vascular malformation. In the episclera, it appears as dilated, tortuous blood vessels that pass from the fornix over the globe surface to the limbal area, without capillary architecture, and then loop backward into the fornix. Fluorescein angiogram reveals the vascular malformation with rapid flow and confirms the episcleral vessels to be large in caliber and with a curvilinear, twisted configuration. Read More

Indian J Otolaryngol Head Neck Surg 2018 Dec 30;70(4):505-509. Epub 2018 Aug 30.

Department of Otorhinolaryngology, Pt. B.D. Sharma, PGIMS, Rohtak, Haryana India.

Twenty five patients of aural polyp who underwent canal wall down mastoidectomy were analysed retrospectively. Histopathological examination revealed cholesteatoma in 22 (88%) patients. However, histopathological diagnosis in 3 of these patients was unusual and rare benign tumors of the middle ear cleft-meningioma, neurilemmoma and capillary hemangioma. Read More

Cardiovasc Pathol 2019 Jan - Feb;38:39-41. Epub 2018 Oct 24.

Department of Pathology, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015-, Paris, France.

We report here a case of capillary vascular malformation developed in a bicuspid aortic valve incidentally detected during valve replacement in a 67-year-old male patient. The International Society for the Study of Vascular Anomalies (ISSVA) classification was used to classify this vascular lesion instead of using the term hemangioma. The differential diagnosis and the literature are reviewed. Read More

J Hand Surg Asian Pac Vol 2018 Dec;23(4):577-580

1 Department of Orthopaedics, Miri General Hospital, Miri, Malaysia.

Pyogenic granuloma, also known as lobular capillary hemangioma, is a benign vascular lesion of the skin or mucous membrane with rapid growth or repetitive trauma. Rarely seen in adult, its management varies and surgical intervention is usually common. We report a case of pyogenic granuloma of the right index finger in a 46-year-old gentleman who presented with painless swelling of the right index finger after a trivial injury. Read More

JAMA Ophthalmol 2019 Jan;137(1):91-95

Vascular Biology Program, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.

Importance: Choroidal hemangiomas are defined by a thickened choroid owing to vessel overgrowth, which may increase the intraocular pressure and lead to glaucoma. Choroidal hemangioma and glaucoma often co-occur in patients with Sturge-Weber syndrome, a rare neurocutaneous disorder characterized by capillary malformations.

Objective: To determine whether the mutation found in most capillary malformations, GNAQ R183Q (c. Read More

Surg Neurol Int 2018 3;9:198. Epub 2018 Oct 3.

Department of Pathology, Santa Rita Hospital, Santa Casa de Misericórdia de Porto Alegre Hospital Complex, Porto Alegre, Brazil.

Background: Hemangiomas are benign vascular malformations that can involve the spine. Pure epidural hemangiomas are rare and represent only 4% of all epidural lesions. Most hemangiomas are of the cavernous type; the capillary variant is atypical, and only ten cases have been reported in the literature. Read More

BMC Ophthalmol 2018 Oct 26;18(1):277. Epub 2018 Oct 26.

Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, China.

Background: The present study reported a case of juxtapapillary retinal capillary hemangioma (JRCH) that was successfully treated by two sessions of full-fluence photodynamic treatment (PDT) with good visual outcome.

Case Presentation: A 19-year-old male patient presented progressive deterioration of the vision of right eye due to the presence of exudative macular detachment associated with JRCH. The best-corrected visual acuity (BCVA) had decreased from 1. Read More

BJR Case Rep 2018 1;4(2):20170022. Epub 2017 Nov 1.

Department of Diagnostic Radiology, Institute of Biomedical and Health Sciences,Hiroshima University, Minami-ku, Hiroshima, Japan.

Anastomosing haemangioma is a rare subtype of capillary haemangioma. Pathologically, anastomosing haemangioma presents with anastomosing sinusoidal capillary-sized vessels in an architecture reminiscent of the splenic parenchyma. Its anastomosing architecture pathologically can lead to concern for angiosarcoma. Read More

Indian J Ophthalmol 2018 Nov;66(11):1644-1646

Department of Ophthalmology, Little Flower Hospital and Research Centre, Angamaly, Kerala, India.

Moyamoya disease (MMD) is a chronic progressive, occlusive cerebrovascular disease in the circle of Willis and the feeding arteries. Morning glory disc anomaly (MGDA) is characterized by an abnormal excavated optic disc with radial emergence of blood vessels from the rim of the disc. We describe a case of moyamoya syndrome (MMS), a rare entity among Indian ethnicity, associated with MGDA and regressed facial capillary hemangiomas, which are relatively less reported presentations of MMD. Read More

Turk J Pediatr 2018 ;60(2):188-190

Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Sepaskhah M, Hajizadeh J, Sari-Aslani F, Jowkar F. Tufted angioma arising at the site of hepatitis B vaccination: A case report. Turk J Pediatr 2018; 60: 188-190. Read More

Ocul Oncol Pathol 2018 Sep 23;4(2):100-106. Epub 2017 Aug 23.

Oxford Eye Hospital, Oxford University Hospital NHS Foundation Trust, University of Oxford, Oxford, UK.

Background: Infantile capillary hemangiomas (IHs) affect approximately 4-5% of infants. The systemic nonselective β-adrenergic antagonist, propranolol, has become the standard first-line treatment for severe IHs. The topical β-antagonist, timolol maleate, has also demonstrated efficacy and safety in treating superficial and some deep capillary hemangiomas. Read More

Case Rep Otolaryngol 2018 18;2018:7413918. Epub 2018 Sep 18.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, Saudi Arabia.

In the present case report, we describe a 33-year-old pregnant woman in the third trimester with a history of recurrent epistaxis leading to frequent visits to the emergency department. Each episode of epistaxis was managed by anterior nasal packing. During endoscopic examination, a left nasal mass was seen. Read More

Pediatr Dermatol 2019 Jan 15;36(1):125-131. Epub 2018 Oct 15.

Department of Dermatology, Hospital Clinico Universitario, Valencia, Spain.

Background/objectives: Infantile hemangiomas (IH) with minimal or arrested growth (MAG) constitute a distinctive subset of IH based on their clinical characteristics and natural history. They are often confused with capillary malformations.

Methods: A retrospective observational study has been carried out in which clinical and perinatal characteristics have been evaluated in all IH-MAG evaluated in our Dermatology Department in a 5-year period (January 2013-December 2017). Read More

Clin Neuropathol 2019 Jan/Feb;38(1):33-37

Filar lipomas are a subtype of spinal lipomas wherein adipose tissue accumulation is restricted to the filum terminale. Embryologically, filar lipomas are considered to occur because of the failure of secondary neurulation, although the precise mechanism is not yet completely understood. Involvement of ectopic mesodermal, ectodermal, and endodermal tissues in spinal lipomas has been occasionally reported, and the origin of these ectopic tissues has been supposed to be migration of pluripotent tissues, which exist during secondary neurulation. Read More

BMJ Case Rep 2018 Oct 7;2018. Epub 2018 Oct 7.

Department of Cardiovascular Radiology & Endovascular Interventions, All India Institute of Medical Sciences, New Delhi, India.

J Am Acad Dermatol 2019 Feb 5;80(2):493-499. Epub 2018 Oct 5.

University of California, San Francisco, California.

Background: The proliferative phase of infantile hemangiomas (IHs) is usually complete by 9 months of life. Late growth beyond age 3 years is rarely reported.

Objective: To describe the demographic and clinic characteristics of a cohort of patients with late growth of IH, defined as growth in a patient >3 years of age. Read More

Radiologia 2019 Jan - Feb;61(1):4-15. Epub 2018 Oct 3.

University of Virginia Health System, Department of Radiology and Medical Imaging, 1215 Lee Street, Charlottesville, Virginia, USA; University of Missouri Health System, Department of Radiology, One Hospital Dr, Columbia, Missouri, USA.

Vascular malformations and tumors, also known as "vascular anomalies", comprise an extensive variety of lesions involving all parts of the body. Knowledge of their classification and imaging characteristics is paramount. Whereas hemangiomas are benign vascular tumors, characterized by cellular proliferation and hyperplasia; vascular malformations are not real tumors and characteristically exhibit normal endothelial turnover. Read More

Pathol Res Pract 2018 Nov 20;214(11):1885-1891. Epub 2018 Sep 20.

Department of Pathology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China. Electronic address:

Background: Solitary pulmonary capillary hemangioma (SPCH) is an extraordinarily rare capillary derived mesenchymal neoplasm. Although routine morphology and immunohistochemistry are adequate for the diagnosis of classical SPCH in surgical specimens, true gross appearance identification of most tumor themselves and diagnosis for some exceptional cases are still very difficult. Furthermore, preoperative imaging and frozen diagnosis remain a challenge. Read More

Lung Cancer 2018 Oct 11;124:227-232. Epub 2018 Aug 11.

Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Objectives: Solitary pulmonary capillary hemangioma (SPCH) is a rare lung tumor typically presenting as pure or part-solid ground-glass nodules (GGNs) on computed tomography (CT), which clinically resembles early lung cancer.

Materials And Methods: In addition to 10 recently diagnosed patients with SPCH, 71 benign lung nodules that were surgically resected between January 2013 and December 2017 were reviewed by thoracic pathologists to identify any previously unrecognized SPCH cases. Finally, 6 tumors (8. Read More

Turk J Gastroenterol 2018 07;29(4):520-521

Department of Digestive Diseases, Huashan Hospital, Fudan University.

G Ital Dermatol Venereol 2018 Oct;153(5):685-691

Unit of Dermatology and Sexually-Trasmitted Diseases, P. Giaccone University Hospital, University of Palermo, Palermo, Italy.

Targetoid hemosiderotic hemangioma represents an uncommon, distinctive, benign lympho-vascular lesion, with a variable clinical appearance, typically occurs in the lower limbs and trunk. Most patients are in their 20's or 30's. We describe three dermoscopic cases followed by the review of the literature. Read More

Radiol Case Rep 2018 Oct 18;13(5):1058-1062. Epub 2018 May 18.

King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.

Capillary hemangiomas are rare benign vascular lesions, commonly found on scalp, face, chest, or back of a neonate or infant. Hemangiomas of the central nervous system are very rare lesions. There are only a few cases of intracranial capillary hemangioma (ICH) arising in adults reported in the literature. Read More

Int J Ophthalmol 2018 18;11(9):1521-1527. Epub 2018 Sep 18.

Department of Ophthalmology, Technical University of Munich, Munich 81675, Germany.

Aim: To describe retinal findings of various imaging modalities in acute retinal ischemia.

Methods: Fluorescein angiography (FA), spectral domain optical coherence tomography (SD-OCT), OCT-angiography (OCT-A) and fundus autofluorescence (FAF) images of 13 patients (mean age 64y, range 28-86y) with acute retinal ischemia were evaluated. Six suffered from branch arterial occlusion, 2 had a central retinal artery occlusion, 2 had a combined arteriovenous occlusions, 1 patient had a retrobulbar arterial compression by an orbital haemangioma and 2 patients showed an ocular ischemic syndrome. Read More

Pediatr Dermatol 2018 Nov 14;35(6):e378-e381. Epub 2018 Sep 14.

Department of Pathology, Institut Imagine, APHP, Hôpital Universitaire Necker-Enfants Malades, Université Paris Descartes - Sorbonne Paris Cité, Paris, France.

Verrucous hemangioma or verrucous venous malformation is a superficial venous malformation frequently misdiagnosed as a lymphatic malformation because of its classical hyperkeratotic appearance. Clinical characteristics of VVM were studied in patients with a histologically confirmed VVM, and validated in a prospective study of 18 patients. VVM was made of separated vascular elements with irregular shape, in a linear disposition, with variable thickness and keratosis. Read More