PLoS One 2021 13;16(5):e0251121. Epub 2021 May 13.
Department of Surgery, Harvard Medical School, The Center for Engineering in Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Several angiogenesis-dependent diseases, including age-related macular degeneration and infantile hemangioma, display differential prevalence among Black, as compared to White individuals. Although socioeconomic status and genetic architecture have been suggested as explaining these differences, we have recently shown that pigment production per se might be involved. For example, we have shown that the extracellular protein fibromodulin is a pro-angiogenic factor highly secreted by melanocytes in White but not Black individuals. Read More