2,212 results match your criteria Hemangioblastoma


Optical coherence tomography angiography in assessment of response to therapy in retinal capillary hemangioblastoma and diffuse choroidal hemangioma.

Indian J Ophthalmol 2019 May;67(5):701-703

Department of Vitreo-Retina and Ocular Oncology, Sankara Eye Hospital, Bangalore, Karnataka, India.

In this series, we discuss the role of optical coherence tomography angiography (OCTA) in assessing response to treatment in intraocular vascular tumors. This is a series of two cases: Multiple retinal capillary hemangioblastoma (RCH) treated with laser photocoagulation and diffuse choroidal hemangioma (DCH) with radiotherapy. In large RCH and DCH, optical coherence tomography (OCT) showed significant reduction of subretinal and intraretinal fluid. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1429_18DOI Listing

Retinal capillary hemangioblastoma associated with retinochoroidal coloboma in Von Hippel-Lindau disease.

Indian J Ophthalmol 2019 May;67(5):688-690

Department of Ophthalmology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

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http://dx.doi.org/10.4103/ijo.IJO_1564_18DOI Listing

Clinical analysis of syringomyelia resulting from spinal hemangioblastoma in a single series of 38 consecutive patients.

Clin Neurol Neurosurg 2019 Apr 1;181:58-63. Epub 2019 Apr 1.

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan province, 450052, PR China; Key laboratory of Neurosurgical Diseases, The First Affiliated Hospital of Zhengzhou University, Jianshe East Road, NO 1, Zhengzhou, Henan Province, 450052, PR China. Electronic address:

Objective: Syringomyelia was predominantly caused by Chiari malformation or intramedullary ependymoma. The goal of this study was to identify factors related to clinical outcomes and spinal hemangioblastoma (SH)-induced syringomyelia formation in a single series of patients.

Patient And Methods: Thirty-eight patients with SH were treated with microsurgery from January 2013 to December 2018. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.03.025DOI Listing
April 2019
1 Read

Spontaneous Hyaloidal Contraction and Complex Retinal Detachment in a Patient With Von Hippel-Lindau Syndrome.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):238-241

The authors present an interventional case report of a patient with von Hippel-Lindau (VHL) syndrome who developed simultaneous exudative and combined tractional, rhegmatogenous, and exudative retinal detachment (RD) in the right and left eyes, respectively, following uneventful cryotherapy application of retinal capillary hemangioblastoma (RCH). After pars plana vitrectomy combined with encircling scleral buckling with radial element placement and silicone oil injection, complete retinal reattachment was achieved. The exudative RD of the fellow eye was managed initially with intense topical corticosteroid treatment and subsequent placement of a radial scleral buckle due to the presence of clinically apparent traction. Read More

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http://dx.doi.org/10.3928/23258160-20190401-07DOI Listing

Distal Outflow-related Anterior Inferior Cerebellar Artery Aneurysm in Hemangioblastoma.

World Neurosurg 2019 Apr 12. Epub 2019 Apr 12.

Department of Neurosurgery, SanBo Brain Hospital, Capital Medical University. Electronic address:

Anterior inferior cerebellar artery (AICA) aneurysm is a rare cerebral entity and its presentation in association with a hyper-vascularized tumor is even more exceptional. In this study, we presented a patient with rare coexistent pathologies in combination of a cerebellar hypervascularized tumor with an outflow related AICA aneurysm. A one-stage procedure to remove both lesions was carried out following meticulous discussion with patient. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.023DOI Listing

68Ga DOTATATE PET/CT Versus 18F-FDG PET/CT for Detecting Intramedullary Hemangioblastoma in a Patient With Von Hippel-Lindau Disease.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Nuclear Medicine & Molecular Imaging Department, Imam Reza International University, Mashhad, Iran.

Von Hippel-Lindau disease is an inherited syndrome associated with several benign and malignant tumors such as central nervous system (CNS) hemangioblastoma. Herein, we report a known case of A Von Hippel-Lindau patient with a cerebral hemangioblastoma who was referred for further evaluation because of recent paraparesis. F-FDG PET/CT showed no focal uptake in the thoracic spine, which demonstrated increased Ga DOTATATE activity, owing to overexpression of somatostatin receptors, suggesting spinal cord hemangioblastoma. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002565DOI Listing
April 2019
1 Read

The loss of succinate dehydrogenase B expression is frequently identified in hemangioblastoma of the central nervous system.

Sci Rep 2019 Apr 10;9(1):5873. Epub 2019 Apr 10.

Department of Pathology, Ajou University School of Medicine, Suwon, 16499, Korea.

Succinate dehydrogenase (SDH) is a mitochondrial enzyme that plays an important role in both the Krebs cycle and the electron transport chain. SDH inactivation is associated with tumorigenesis in certain types of tumor. SDH consists of subunits A, B, C and D (SDHA, SDHB, SDHC, and SDHD, respectively). Read More

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http://dx.doi.org/10.1038/s41598-019-42338-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458311PMC

Renal Cell Carcinoma With Hemangioma-Like Features: Diagnostic Implications and Review of the Literature.

Int J Surg Pathol 2019 Apr 8:1066896919840435. Epub 2019 Apr 8.

2 Yonsei University, Seoul, Republic of Korea.

Renal cell carcinoma (RCC) with clear cell morphology may show a prominent delicate vascularity. In this article, we report the morphologic and immunohistochemical features of a clear cell papillary RCC mimicking hemangioblastoma and a clear cell RCC mimicking hemangioma. Case 1 showed tubular and papillary growth of clear cells with distinctive areas of capillary proliferation and admixed stromal-like cells resembling a hemangioblastoma. Read More

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http://dx.doi.org/10.1177/1066896919840435DOI Listing
April 2019
1 Read

A synonymous VHL variant in exon 2 confers susceptibility to familial pheochromocytoma and von Hippel-Lindau disease.

J Clin Endocrinol Metab 2019 Apr 4. Epub 2019 Apr 4.

Division of Hematology and Medical Oncology, Department of Medicine, Mays Cancer Center, UT Health San Antonio, San Antonio, TX, USA.

Context: von Hippel-Lindau disease, comprising renal cancer, hemangioblastoma and/or pheochromocytoma (PHEO) is caused by missense or truncating variants of the VHL tumor suppressor gene, which is involved in degradation of hypoxia inducible factors (HIFs). However, the role of synonymous VHL variants in the disease is unclear.

Objective: We evaluated a synonymous VHL variant in patients with familial PHEO or VHL disease without a detectable pathogenic VHL mutation. Read More

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http://dx.doi.org/10.1210/jc.2019-00235DOI Listing
April 2019
2 Reads

SEGMENTAL DIFFUSE VASCULAR LEAKAGE: A FLUORESCEIN ANGIOGRAPHIC FINDING IN PATIENTS WITH VON HIPPEL-LINDAU DISEASE.

Retin Cases Brief Rep 2019 Mar 28. Epub 2019 Mar 28.

Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Purpose: To describe a novel fluorescein angiographic finding in patients with von Hippel-Lindau disease.

Methods: Retrospective case series of patients diagnosed with retinal capillary hemangioblastoma (RCH) in the setting of von Hippel-Lindau.

Results: We identified six eyes of three patients with von Hippel-Lindau and leaky retinal vessels. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000868DOI Listing
March 2019
1 Read

Hemangioblastoma of the Cerebral Aqueduct Removed via a Sitting, Supracerebellar Intracollicular Approach.

World Neurosurg 2019 Mar 27. Epub 2019 Mar 27.

Center for Minimally Invasive Neurosurgery Prince of Wales Private Hospital Sydney, Australia. Electronic address:

Background: Tumors protruding into the cerebral aqueduct are rare, and tumors arising from within the cerebral aqueduct are rarer still.

Case Description: In this report, we discuss the presentation and clinical outcome of a 65-year-old man who presented to us with symptoms of hydrocephalus. Prior imaging had revealed a small enhancing nodule within the cerebral aqueduct. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.206DOI Listing

Fully endoscopic minimally-invasive tumor resection for cystic cerebellar hemangioblastoma: Technical Note.

World Neurosurg 2019 Mar 25. Epub 2019 Mar 25.

Department of Neurosurgery, the University of Tokyo Hospital, Tokyo, Japan.

Background: von-Hippel Lindau disease (VHL)-related hemangioblastoma is likely to occur in the cerebellum and accompany a cyst. Since multiple hemangioblastomas commonly occur in VHL and multiple surgeries may thus be necessary, a minimally-invasive surgical strategy is of great importance.

Methods: We present two patients with VHL-related hemangioblastomas successfully treated by a fully-endoscopic transcranial approach via a short skin incision and a 2 cm × 2 cm small bony window. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.158DOI Listing

Familial Cavernous Hemangioma.

J Neuroophthalmol 2019 Mar 18. Epub 2019 Mar 18.

Baylor College of Medicine (GT), Houston, Texas; Department of Ophthalmology (ATK, BAO, AGL), Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas; The Houston Methodist Research Institute (AGL), Houston Methodist Hospital, Houston, Texas; Departments of Ophthalmology, Neurology, and Neurosurgery (AGL), Weill Cornell Medicine, New York, New York; Department of Ophthalmology (AGL), University of Texas Medical Branch, Galveston, Texas; University of Texas MD Anderson Cancer Center (AGL), Houston, Texas; Texas A and M College of Medicine (AGL), Bryan, Texas; and Department of Ophthalmology (AGL), The University of Iowa Hospitals and Clinics, Iowa City, Iowa.

A 30-year-old woman presented with diplopia after resection of an intracranial cavernous malformation. Fundus examination showed an asymptomatic intraocular cavernous hemangioma of the retina. Clinicians should be aware of the potential coexistence of intraocular and intracranial cavernous malformations; the presence of both should suggest familial etiology. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000778DOI Listing
March 2019
4 Reads

Endoresection utilizing pars plana vitrectomy for benign and malignant intraocular tumors.

Curr Opin Ophthalmol 2019 May;30(3):151-158

Tennessee Retina, Nashville, TN, USA.

Purpose Of Review: Endoresection of intraocular tumors is a complicated procedure utilizing pars plana vitrectomy techniques. Though it has potential downsides and complications, there is potential for this technique in the treatment of malignant and benign intraocular tumors.

Recent Findings: Endoresection has been utilized in some form for the last three decades, but recent advances in vitreoretinal surgery have improved the technique. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000561DOI Listing
May 2019
1 Read

Metastatic Renal Cell Carcinoma to the Brain: A Contemporary Clinicopathologic Analysis With Comparison of Immunohistochemical Profiles to Selected Primary Brain Tumors With Clear Cell Features.

Appl Immunohistochem Mol Morphol 2019 Mar 13. Epub 2019 Mar 13.

Departments of Pathology.

Brain metastases from renal cell carcinoma (RCC) are associated with significant morbidity and mortality. However, there are only few large series in the pathology literature specifically analyzing the clinicopathologic and immunohistochemical features in comparison with primary brain tumors with clear cell features. We identified 34 cases of metastatic RCC to the brain from the Urologic Pathology and Neuropathology files of 2 institutions between 2000 and 2018. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000759DOI Listing
March 2019
1 Read

Characteristics and outcomes in patients with primary intraspinal tumours.

Dan Med J 2019 Mar;66(3)

Introduction: We report a retrospective cohort study aimed at presenting data on incidence, patient char-ac-teristics, tumour type, level of pathology, clinical status before and after surgery and complications in patients with surgically treated primary intraspinal tumours (PIST) in Western Denmark.

Methods: Population-based data were retrieved from hospital files from 1 January 2010 to 31 December 2015.

Results: In total, 78 males and 88 females with PIST were included in the study. Read More

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March 2019
1 Read

Von Hippel Lindau Disease.

J Pediatr 2019 Mar 7. Epub 2019 Mar 7.

Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

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http://dx.doi.org/10.1016/j.jpeds.2019.01.053DOI Listing

Exoscope-Guided (VITOM 3D) Single-Stage Removal of Supratentorial Cavernous Angioma and Hemangioblastoma: 3-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2019 Mar 8. Epub 2019 Mar 8.

Division of Neurosurgery, Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, University of Messina, Messina, Italy.

This video shows an exoscope-guided single-stage resection with 3-dimensional technology of a supratentorial cavernoma and a supratentorial hemangioblastoma during the same surgical procedure. The patient is a 42-yr-old man with a history of generalized tonico-clonic seizures. Contrast-enhanced magnetic resonance (MR) revealed the presence of a left frontal cavernoma and a left T1 non-enhancing hypointese temporal lesion (hemangioblastoma). Read More

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http://dx.doi.org/10.1093/ons/opz010DOI Listing
March 2019
5 Reads

Desmoid tumor after resection of cerebellar hemangioblastoma.

J Neurosurg Sci 2019 Apr;63(2):224-230

Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran.

Desmoid tumors are histologically benign but locally invasive tumors that rarely can occur in the head and neck. In this article, we illustrate a rare case of desmoid tumor formation in intracranial posterior fossa after suboccipital craniotomy for hemangioblastoma. A 43-year-old woman presented with headaches, dizziness, equilibrium disorders, nausea, and vomiting due to a hemangioblastoma in posterior fossa. Read More

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http://dx.doi.org/10.23736/S0390-5616.16.03398-1DOI Listing
April 2019
3 Reads
0.780 Impact Factor

Proton beam radiotherapy (PBR) for the treatment of retinal capillary haemangioblastoma stabilises tumour progression but with poor visual outcomes.

Eye (Lond) 2019 Feb 21. Epub 2019 Feb 21.

Liverpool Ocular Oncology Service, St Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, L7 8XP, UK.

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http://dx.doi.org/10.1038/s41433-019-0377-3DOI Listing
February 2019
1 Read

Cauda Equina Syndrome as the first Manifestation of von Hippel-Lindau Disease: A Case Report.

World Neurosurg 2019 Feb 16. Epub 2019 Feb 16.

Department of Orthopedics, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China; Hangzhou Medical College People's Hospital, Hangzhou, Zhejiang, China. Electronic address:

Background: Von-Hippel Lindau (VHL) disease is rare neurocutaneous disorder arising from an inactivating mutation of the VHL gene on chromosome 3p35. The disease is inherited in an autosomal dominant fashion and predominantly involves tissues originating from the ectodermal germ layer. Although hemangioblastomas of retina and cerebellum are the most common clinical features, multiple-organ involvement in the form of renal cell carcinomas, spinal hemangioblastomas, renal cysts, pancreatic cysts have also been reported. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.269DOI Listing
February 2019
6 Reads

Congenital extraneural hemangioblastoma in a lamb.

J Vet Diagn Invest 2019 Mar 17;31(2):263-266. Epub 2019 Feb 17.

Departments of Surgery (Karasu, Kuşçu).

A 1-mo-old Ivesi male lamb was presented with 2 large red masses on the skin of the left ear. The tumors were removed using gentle dissection and submitted for histologic evaluation. The tumors consisted of numerous thin-walled capillaries lined by endothelial cells and nests of stromal cells. Read More

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http://dx.doi.org/10.1177/1040638719830464DOI Listing
March 2019
1 Read

Resection of a cerebellar hemangioblastoma via a minimally invasive tubular approach.

J Clin Neurosci 2019 May 4;63:240-243. Epub 2019 Feb 4.

Department of Neurosurgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address:

Hemangioblastomas are rare benign, highly vascularized tumors occurring in the cerebellum and the spinal cord. They often develop tumor-associated cysts multiple times the size of the solid part of the tumor. Patients with von Hippel-Lindau (VHL) disease typically exhibit multiple tumors with the need of repeated surgeries during their lifetime. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.045DOI Listing
May 2019
1 Read

Gamma Knife Stereotactic Radiosurgery favorably changes the clinical course of hemangioblastoma growth in von Hippel-Lindau and sporadic patients.

J Neurooncol 2019 Feb 7. Epub 2019 Feb 7.

Departments of Neurosurgery, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA.

Purpose: This is the first single-institution study of its size to characterize the treatment impact and to address the question of whether hemangioblastoma treatment with Gamma Knife Stereotactic Radiosurgery (GKRS) in both sporadic and VHL patients changes the characteristic saltatory hemangioblastoma growth pattern.

Methods: The authors reviewed a single-institution tumor registry to identify patients who had received GKRS for hemangioblastomas between January 1st, 1999, and December 31st, 2017.

Results: 15 patients with 101 lesions met search criteria with a median age of first GKRS of 39. Read More

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http://dx.doi.org/10.1007/s11060-019-03118-xDOI Listing
February 2019
2 Reads

Imaging of Vascular Disorders of the Spine.

Radiol Clin North Am 2019 Mar 15;57(2):307-318. Epub 2018 Nov 15.

Neuroradiology Division, Department of Radiology and Imaging Sciences, University of Utah Health Sciences Center, 30 North, 1900 East, #1A071, Salt Lake City, UT 84132-2140, USA.

Vascular disorders of the spine are more rare than cerebral vascular entities but can result in significant morbidity. These lesions frequently demonstrate distinguishing characteristics by imaging that are imperative for the radiologist to recognize to properly guide diagnosis and treatment. We review distinguishing imaging characteristics for spinal vascular malformations, spinal emergencies, and spinal vascular masses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00338389183012
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http://dx.doi.org/10.1016/j.rcl.2018.09.005DOI Listing
March 2019
9 Reads

Dysphagia: an unusual presentation of Von Hippel-Lindau disease.

Postgrad Med J 2019 Jan 30. Epub 2019 Jan 30.

Department of Endocrinology, Post Graduate Institute for Medical Education and Research, Chandigarh, India

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http://dx.doi.org/10.1136/postgradmedj-2018-136033DOI Listing
January 2019
3 Reads

Disseminated central nervous system hemangioblastoma in a patient with no clinical or genetic evidence of von Hippel-Lindau disease-a case report and literature review.

Acta Neurochir (Wien) 2019 Feb 17;161(2):343-349. Epub 2019 Jan 17.

Department of Oncology, Oslo University Hospital, Oslo, Norway.

Background: Hemangioblastomas (HB) are benign tumors of the central nervous system (CNS) that can appear sporadic or as part of von Hippel-Lindau (VHL) disease. It is often curable with surgical resection, but upon relapse, the disease exhibits a treatment-refractory course.

Case Report: A patient treated for sporadic cerebellar HB relapsed 12 years post-surgery. Read More

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http://dx.doi.org/10.1007/s00701-019-03800-zDOI Listing
February 2019
4 Reads

The role of diffusion and perfusion magnetic resonance imaging in differentiation of haemangioblastomas and pilocytic astrocytomas.

Pol J Radiol 2018 10;83:e197-e203. Epub 2018 May 10.

Department of General and Interventional Radiology and Neuroradiology, Wroclaw Medical University, Poland.

Purpose: Haemangioblastomas (HABLs) and pilocytic astrocytomas (PAs) are brain tumours presenting similar appearance and location in conventional magnetic resonance (MR) imaging. The purpose of our study was to determine whether a detailed analysis of diffusion (DWI) and perfusion (PWI) characteristics can be useful in preoperative differentiation of these tumours.

Material And Methods: The study group consisted of biopsy proven six HABLs and six PAs, which underwent preoperative standard MR examinations including PWI and DWI. Read More

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https://www.termedia.pl/doi/10.5114/pjr.2018.75870
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http://dx.doi.org/10.5114/pjr.2018.75870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323599PMC
May 2018
7 Reads

Intermittent Myokymia as a Pointer to Hemangioblastoma of the Cervical Spine: A Case Report.

Case Rep Neurol 2018 Sep-Dec;10(3):338-341. Epub 2018 Dec 4.

REHAB Basel, Clinic for Neurorehabilitation and Paraplegiology, Basel, Switzerland.

Hemangioblastomas represent 3% of all central nervous system (CNS) tumors. The majority of CNS hemangioblastomas are infratentorial, with the cerebellum being the most frequent location, while 13% are found in the brainstem. Symptoms of brainstem hemangioblastomas can be very subtle and might therefore be overlooked or misinterpreted. Read More

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http://dx.doi.org/10.1159/000494878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323388PMC
December 2018
5 Reads

[Magnetic Resonance Imaging Features of the Supratentorial Extra-axial Hemangioblastoma:A Case Report].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2018 Dec;40(6):847-849

Department of Radiology,Hainan Branch of Chinese PLA General Hospital,Sanya,Hainan 572013,China.

We reported a case of supratentorial extra-axial hemangioblastoma diagnosed by magnetic resonance imaging (MRI). As a simple solid mass,this tumor has its unique MRI features due to its tissue structures. Read More

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http://dx.doi.org/10.3881/j.issn.1000-503X.10216DOI Listing
December 2018
1 Read

Intramedullary and intratumoral hemorrhage in spinal hemangioblastoma: Case report and review of literature.

Surg Neurol Int 2018 4;9:250. Epub 2018 Dec 4.

Department of Neurosurgery, Tokyo Metropolitan Police Hospital, Tokyo, Japan.

Background: Intramedullary hemorrhages involving spinal hemangioblastomas are rare. They are frequently associated with devastating neurologic outcomes, despite with emergent surgical intervention. Here, we presented an example of an intramedullary hemorrhage occurring in a spinal hemangioblastoma, where the patient markedly improved with surgery. Read More

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http://dx.doi.org/10.4103/sni.sni_344_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293603PMC
December 2018
4 Reads

Optic Nerve Haemangioblastoma: Signs of Chronicity.

Ocul Oncol Pathol 2018 Nov 23;4(6):370-374. Epub 2018 Feb 23.

Sheffield Ocular Oncology Service, Royal Hallamshire Hospital, Sheffield, United Kingdom.

Optic nerve haemangioblastomas remain exceedingly rare extrinsic tumours of the optic nerve, often associated with von Hippel-Lindau disease. The authors report a 25-year-old female with a slowly progressive unilateral optic nerve lesion, causing reduced vision and bilateral optic tract oedema. A diagnosis of optic nerve haemangioblastoma with piloid gliosis was made histologically after surgical resection. Read More

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http://dx.doi.org/10.1159/000486863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288663PMC
November 2018
2 Reads

Sporadic Hemangioblastoma of the Cavernous Sinus and Meckel's Cave.

J Neurol Surg Rep 2018 Oct 12;79(4):e98-e102. Epub 2018 Dec 12.

Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama, United States.

 To describe an extremely rare case of sporadic hemangioblastoma (HB) within the cavernous sinus and Meckel's cave with extension to the cerebellopontine angle (CPA) cistern.  A 73-year-old male presented with hearing loss, unilateral ptosis, and facial numbness.  The imaging showed a complex cystic-solid mass centered at the left cavernous sinus and Meckel's cave with extension to the CPA cistern. Read More

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http://dx.doi.org/10.1055/s-0038-1676455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291399PMC
October 2018
1 Read

Magnetic resonance spectroscopy in posterior fossa tumours: the tumour spectroscopic signature may improve discrimination in adults among haemangioblastoma, ependymal tumours, medulloblastoma, and metastasis.

Eur Radiol 2018 Dec 19. Epub 2018 Dec 19.

Department of Radiology, Institut de Diagnòstic per la Imatge (IDI), Centre Bellvitge, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain.

Objectives: Assessing a posterior fossa tumour in an adult can be challenging. Metastasis, haemangioblastoma, ependymal tumours, and medulloblastoma are the most common diagnostic possibilities. Our aim was to evaluate the contribution of magnetic resonance spectroscopy (MRS) in the diagnosis of these entities. Read More

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http://dx.doi.org/10.1007/s00330-018-5879-zDOI Listing
December 2018
3 Reads

Spontaneous Arrest of Sporadic Spinal Hemangioblastoma Growth after Postoperative Nodular Recurrence: Case Report.

Cureus 2018 Sep 28;10(9):e3380. Epub 2018 Sep 28.

Neurosurgery, The Icahn School of Medicine at Mount Sinai, New York, USA.

Hemangioblastomas are rare, slow-growing, highly vascularized tumors of the central nervous system which often occur in the spinal cord. When presenting as sporadic, isolated tumors without Von-Hippel Lindau disease, they are curable through surgery with a low rate of recurrence. Tumor recurrence in these cases is usually associated with prior subtotal resection. Read More

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http://dx.doi.org/10.7759/cureus.3380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263517PMC
September 2018
3 Reads

Repurposing propranolol as an antitumor agent in von Hippel-Lindau disease.

J Neurosurg 2018 Oct 1:1-9. Epub 2018 Oct 1.

1Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.

OBJECTIVEVon Hippel-Lindau disease (VHL) is a tumor predisposition syndrome characterized by CNS hemangioblastomas (HBs) and clear cell renal cell carcinomas (RCCs) due to hypoxia-inducible factor activation (pseudohypoxia). Because of the lack of effective medical therapies for VHL, HBs and RCCs account for significant morbidity and mortality, ultimately necessitating numerous neurological and renal surgeries. Propranolol is an FDA-approved pan-beta adrenergic antagonist with antitumor effects against infantile hemangiomas (IHs) and possibly VHL HBs. Read More

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http://dx.doi.org/10.3171/2018.5.JNS172879DOI Listing
October 2018
3 Reads
3.737 Impact Factor

A novel mutation in the VHL gene in a Chinese family with von Hippel-Lindau disease.

BMC Med Genet 2018 Nov 26;19(1):204. Epub 2018 Nov 26.

Department of Ophthalmology, Chinese PLA General Hospital, Beijing, 100853, China.

Background: Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited cancer syndrome, and VHL is identified as a tumor suppressor gene. The main objective of this study was to identify disease-causing mutations in a Chinese family affected with VHL disease.

Methods: Genomic DNA was extracted from peripheral blood from a Chinese family with VHL. Read More

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https://bmcmedgenet.biomedcentral.com/articles/10.1186/s1288
Publisher Site
http://dx.doi.org/10.1186/s12881-018-0716-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258150PMC
November 2018
13 Reads

A mobile hemangioblastoma of the cauda equina: Case report and review of the literature.

J Spinal Cord Med 2018 Nov 26:1-4. Epub 2018 Nov 26.

a Department of Neurosurgery , The Second Affiliated Hospital of Nanchang University , Nanchang , People's Republic of China.

Context: Cases of migratory spinal tumors have been reported since 1963. Most involve spinal schwannomas, which are benign tumors of the lining of nerve cells. We report a rare case of a mobile spinal hemangioblastoma, which is a type of benign vascular tumor. Read More

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http://dx.doi.org/10.1080/10790268.2018.1547855DOI Listing
November 2018

Risk of radiation-associated intracranial malignancy after stereotactic radiosurgery: a retrospective, multicentre, cohort study.

Lancet Oncol 2019 Jan 22;20(1):159-164. Epub 2018 Nov 22.

Department of Neurosurgery, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health System, New York University, New York, NY, USA. Electronic address:

Background: A major concern of patients who have stereotactic radiosurgery is the long-term risk of having a secondary intracranial malignancy or, in the case of patients with benign tumours treated with the technique, the risk of malignant transformation. The incidence of stereotactic radiosurgery-associated intracranial malignancy remains unknown; therefore, our aim was to estimate it in a population-based study to assess the long-term safety of this technique.

Methods: We did a population-based, multicentre, cohort study at five international radiosurgery centres (Na Homolce Hospital, Prague, Czech Republic [n=2655 patients]; Ruber International Hospital, Madrid, Spain [n=1080], University of Pittsburgh Medical Center, Pittsburgh, PA, USA [n=1027]; University of Virginia, Charlottesville, VA, USA [n=80]; and NYU Langone Health System, New York, NY, USA [n=63]). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14702045183065
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http://dx.doi.org/10.1016/S1470-2045(18)30659-4DOI Listing
January 2019
21 Reads

A Rare Complication of Endovascular Embolization: Extruded Onyx on Trigeminal Nerve.

J Neurol Surg B Skull Base 2018 Dec 25;79(Suppl 5):S422-S423. Epub 2018 Sep 25.

Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States.

 To demonstrate a rare complication of endovascular tumor embolization with onyx.  Operative video.  Department of neurological surgery in a university hospital. Read More

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http://dx.doi.org/10.1055/s-0038-1669972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240439PMC
December 2018
15 Reads

A case report on cystic meningioma in cerebellopontine angle and recommendations for management.

Medicine (Baltimore) 2018 Nov;97(46):e13179

Department of Neurosurgery, West China Hospital, Sichuan University.

Rationale: Cystic meningioma located at the cerebellopontine angle (CPA) is an extremely rare occurrence. It is frequently misdiagnosed preoperatively. Little is known about the clinical features and outcome of this rare disease. Read More

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http://dx.doi.org/10.1097/MD.0000000000013179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257460PMC
November 2018
3 Reads

Retromedullary Hemangioblastoma Mimicking a Posterior Inferior Cerebellar Artery Aneurysm: Case Report and Literature Review.

World Neurosurg 2019 Feb 4;122:165-170. Epub 2018 Nov 4.

Texas A&M College of Medicine, Temple, Texas, USA; Department of Neurosurgery, Baylor Scott and White Health, Temple, Texas, USA. Electronic address:

Background: Hemangioblastomas (HBMs) are benign vascular neoplasms that most commonly arise within the cerebellum. Although other vascular lesions should be considered in the differential diagnosis, HBMs rarely resemble aneurysms on neuroimaging and only 1 case of a cerebellar HBM mimicking a posterior fossa aneurysm has been reported. Here we describe a retromedullary HBM that masqueraded as a distal posterior inferior cerebellar artery (PICA) medullary branch aneurysm. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183249
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http://dx.doi.org/10.1016/j.wneu.2018.10.188DOI Listing
February 2019
17 Reads

Surgical Treatment of Vascular Intramedullary Spinal Cord Lesions.

Cureus 2018 Aug 16;10(8):e3154. Epub 2018 Aug 16.

Neurosurgery, University of Miami Miller School of Medicine, Miami, USA.

Background Vascular lesions represent a rare subset of intramedullary spinal cord pathology and consist of cavernous malformations (CM), hemangioblastomas, and arteriovenous malformations (AVM). These lesions are each unique and the literature pertaining to their surgical management is largely limited to retrospective case series and case reports. Objectives To evaluate the surgical management of each of these lesions with special attention to postoperative functional status. Read More

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https://www.cureus.com/articles/11906-surgical-treatment-of-
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http://dx.doi.org/10.7759/cureus.3154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191006PMC
August 2018
14 Reads

A Rare Case of Giant Solid Hemangioblastoma Accompanied with Hemophilia Type A.

NMC Case Rep J 2018 Oct 13;5(4):95-97. Epub 2018 Sep 13.

Department of Neurosurgery, Kurashiki Central Hospital, Kurashiki, Okayama, Japan.

The surgical removal of giant solid hemangioblastoma involves a high risk of perioperative bleeding and requires attentive hemostasis. Here, we present a case of a giant solid hemangioblastoma accompanied with hemophilia which was previously undiagnosed. A 35-year-old man without any past medical history was admitted with diplopia and ocular motility disorder. Read More

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https://www.jstage.jst.go.jp/article/nmccrj/5/4/5_cr.2018-00
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http://dx.doi.org/10.2176/nmccrj.cr.2018-0062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187256PMC
October 2018
5 Reads

Hemangioblastoma of the optic nerve.

Surv Ophthalmol 2019 Mar - Apr;64(2):175-184. Epub 2018 Oct 13.

Sheffield Ocular Oncology Service, Royal Hallamshire Hospital, Sheffield, UK.

Optic nerve hemangioblastoma is a rare tumor that is usually unilateral and most commonly occurs in the context of von Hippel-Lindau disease. Differential diagnosis is based on clinical history and imaging. Magnetic resonance imaging with gadolinium enhancement is the most useful imaging modality as it can reveal flow voids and an absence of dural attachment, differentiating optic nerve hemangioblastoma from other more commonly encountered optic nerve tumors. Read More

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http://dx.doi.org/10.1016/j.survophthal.2018.10.002DOI Listing
February 2019
4 Reads

Pathological features of paraganglioma in the lumbar spinal canal: A case report.

Medicine (Baltimore) 2018 Oct;97(41):e12586

Department of Pathology, China-Japan Union Hospital of Jilin University.

Introduction: This study aims to investigate the pathological features of a patient with paraganglioma in the lumbar spinal canal.

Case Presentation: The patient was 36 years old male with electrical pain in the waist and buttock which occurred intermittently, and was not relieved under oral use of analgesics. Immunohistochemical staining was performed to diagnose the disease. Read More

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http://dx.doi.org/10.1097/MD.0000000000012586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203573PMC
October 2018
3 Reads

Peripheral retinal nonperfusion using widefield imaging with von Hippel-Lindau disease.

Int J Retina Vitreous 2018 3;4:36. Epub 2018 Oct 3.

3Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, 840 Walnut Street, 14th Floor, Philadelphia, PA 19107 USA.

Background: To describe a case of von Hippel-Lindau disease with peripheral retinal nonperfusion.

Case Presentation: A 66-year-old female with known cerebellar and midbrain hemangioblastomas was evaluated for a retinal hemangioblastoma in the right eye. She underwent widefield fluorescein angiography, which showed hyperfluorescence localized to the hemangioblastoma surrounded by peripheral retinal nonperfusion in the same quadrant. Read More

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http://dx.doi.org/10.1186/s40942-018-0139-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168996PMC
October 2018
1 Read

The Application of FLOW 800 ICG Videoangiography Color Maps for Neurovascular Surgery and Intraoperative Decision Making.

World Neurosurg 2019 Feb 5;122:e186-e197. Epub 2018 Oct 5.

Department of Neurological Surgery, Goodman Campbell Brain and Spine and Indiana University, Indianapolis, Indiana, USA. Electronic address:

Background: Indocyanine green (ICG) videoangiography can assess cerebral blood flow, but results are primarily qualitative. FLOW 800 software measures fluorescence dynamics and creates a semiquantitative color delay map for assessment of relative sequence of blood flow within the vasculature.

Methods: We retrospectively reviewed 23 consecutive patients for whom FLOW 800 ICG videoangiography was used. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.195DOI Listing
February 2019
2 Reads

Hemangioblastomatosis-associated negative-pressure hydrocephalus managed with improvised shunt.

J Clin Neurosci 2018 Dec 1;58:226-228. Epub 2018 Oct 1.

National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA. Electronic address:

Low-pressure hydrocephalus (LPH) is a rare clinical diagnosis, characterized by neurologic decline and ventriculomegaly that persists despite normal to low intracranial pressure. LPH is typically managed by negative-pressure drainage via ventriculostomy, followed by low-resistance shunt insertion. We present the case of a middle-aged man with a history of hemangioblastomatosis who had spontaneous subarachnoid hemorrhage. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868183059
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http://dx.doi.org/10.1016/j.jocn.2018.08.028DOI Listing
December 2018
14 Reads

[Relevance of histopathological diagnosis in the treatment of brainstem lesions in adults].

Medicina (B Aires) 2018 ;78(5):305-310

División Neurocirugía, Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Argentina.

Brainstem tumors are uncommon beyond childhood. Controversies arise regarding the need of histological diagnosis in this eloquent area of the brain, weighting the benefits of a reliable diagnosis against the disadvantages of invasive procedures. There are scant publications about the surgical management of brainstem tumors in adults, all of them involving small retrospective cohorts. Read More

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January 2018
4 Reads