6,110 results match your criteria Hellenic journal of cardiology : HJC = Hell?nik? kardiologik? epithe?r?s?[Journal]


Epidemiology of Taenia saginata taeniosis/cysticercosis in the Russian Federation.

Parasit Vectors 2018 Dec 14;11(1):636. Epub 2018 Dec 14.

Section of Epidemiology, Vetsuisse Faculty, University of Zurich, 8057, Zurich, Switzerland.

Background: Russia is traditionally an endemic area for Taenia saginata infection, where a programme for the prevention of infection has been implemented for sixty years. This paper aims, therefore, to review the recent epidemiology data of Taenia saginata infection in the Russian Federation.

Methods: We undertook a systematic review of published and grey literature, and official data for information on the incidence, prevalence and distribution of Taenia saginata taeniosis and cysticercosis in the Russian Federation between 1st January 1991 and 31st December 2017. Read More

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December 2018

Relapsed and De Novo Metastatic HER2-positive Breast Cancer Treated With Trastuzumab: Tumor Genotypes and Clinical Measures Associated With Patient Outcome.

Clin Breast Cancer 2018 Nov 5. Epub 2018 Nov 5.

Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece; Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background: We examined tumor genotype characteristics of human epidermal growth factor receptor 2 (HER2)-positive relapsed (R-) and de novo (dn-) metastatic breast cancer (MBC) in trastuzumab-treated patients who were previously not exposed to this agent.

Materials And Methods: We analyzed genotypes obtained upon deep sequencing from 113 HER2-positive primary tumors from 69 patients with R-MBC and 44 patients with dn-MBC.

Results: Mutations were observed in 90 (79. Read More

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November 2018

The Impact of Stress on Pressure Ulcer Wound Healing Process and on the Psychophysiological Environment of the Individual Suffering from them.

Med Arch 2018 Nov;72(5):362-366

Nursing Program and Postgraduate program Contemporary Nursing, University of Nicosia, Nicosia, Cyprus.

Introduction: The occurrence of a pressure ulcer constitutes a major psychological and physiological burden and it has been linked with a reduced quality of life and increased stress of the individual.

Objective: The main objective was to investigate the impact that stress has on pressure ulcer healing process and on the psychophysiological environment of the individual suffering from them.

Method: The scientific literature was reviewed through Cinahl, Pub-med, EBSCO, Medline and Google scholar. Read More

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November 2018

Breast Cancer Risk After Recent Childbirth: A Pooled Analysis of 15 Prospective Studies.

Ann Intern Med 2018 Dec 11. Epub 2018 Dec 11.

National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina (C.R.W., D.P.S.).

Background: Parity is widely recognized as protective for breast cancer, but breast cancer risk may be increased shortly after childbirth. Whether this risk varies with breastfeeding, family history of breast cancer, or specific tumor subtype has rarely been evaluated.

Objective: To characterize breast cancer risk in relation to recent childbirth. Read More

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December 2018
1 Read
17.810 Impact Factor

Recellularization potential of small diameter vascular grafts derived from human umbilical artery.

Biomed Mater Eng 2018 Dec 4. Epub 2018 Dec 4.

Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, 4 Soranou Ephessiou Street, Athens 115 27, Greece.

Background: The primary therapeutic strategy in cardiovascular disease is the coronary artery bypass surgery, which involves the use of small diameter vascular grafts ( <6 mm). Human umbilical arteries could be used as a source for the development of these grafts.

Objective: The aim of this study was the decellularization of human umbilical arteries and the evaluation of their recellularization potential. Read More

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December 2018

Methodological issues in a prospective study on plasma concentrations of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort.

Environ Res 2018 Nov 23;169:417-433. Epub 2018 Nov 23.

Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Catalonia, Spain; Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. Electronic address:

Background: The use of biomarkers of environmental exposure to explore new risk factors for pancreatic cancer presents clinical, logistic, and methodological challenges that are also relevant in research on other complex diseases.

Objectives: First, to summarize the main design features of a prospective case-control study -nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort- on plasma concentrations of persistent organic pollutants (POPs) and pancreatic cancer risk. And second, to assess the main methodological challenges posed by associations among characteristics and habits of study participants, fasting status, time from blood draw to cancer diagnosis, disease progression bias, basis of cancer diagnosis, and plasma concentrations of lipids and POPs. Read More

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November 2018

The posterior portion of the ilium as a sex indicator: A validation study.

Forensic Sci Int 2018 Nov 11. Epub 2018 Nov 11.

Edinburgh Unit For Forensic Anthropology, School of History, Classics and Archaeology, University of Edinburgh, 4 Teviot Place, EH8 9AG, United Kingdom; Forensic Pathology Division Crete, Hellenic Republic Ministry of Justice and Human Rights, Heraklion, Crete, Greece.

Establishing a biological profile of skeletal remains is a key task of forensic anthropologists. Sex estimation is essential in forensic examination, as other elements of the biological profile, such as age at death or stature, are sex dependent. Visual assessment is considered low-cost and quick, therefore it is a commonly applied method of sex estimation. Read More

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November 2018

Cardiovascular Disease statistics: the Greek reality.

Authors:
Costas Tsioufis

Hellenic J Cardiol 2018 Dec 5. Epub 2018 Dec 5.

National and Kapodistrian University of Athens, First Cardiology Clinic, Medical School, Hippokration Hospital, 114 Vas. Sofias Ave, 11527, Athens, Greece. Electronic address:

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December 2018

Chronic total occlusion: The puzzle is not yet solved.

Hellenic J Cardiol 2018 Dec 5. Epub 2018 Dec 5.

1(st) Cardiology Department, National and Kapodistrian University of Athens University Medical School, Hippokration Hospital, Athens, Greece. Electronic address:

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December 2018

GLP-1 receptor agonists and cardiovascular outcome trials: An update.

Hellenic J Cardiol 2018 Dec 6. Epub 2018 Dec 6.

Diabetes Centre, Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece.

Major cardiovascular (CV) outcome trials with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are currently available. These agonists have proven their CV safety, in harmony with the US Food and Drug Administration (FDA) recommendation for antidiabetic drugs. The potential cardioprotective effect of incretin-based therapies is attributed to their multiple non-glycaemic actions in the CV system, including changes in insulin resistance, weight loss, reduction in blood pressure, improved lipid profile and direct effects on the heart and vascular endothelium. Read More

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December 2018

The effectiveness of biodegradable instrumentation in the treatment of spinal fractures.

Injury 2018 Dec;49(12):2111-2120

Department of Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch, Galveston, TX, USA. Electronic address:

Introduction: A variety of biodegradable implants (screws, rods, plates and cages) are available which are composed of many different biodegradable polymers with varying characteristics. The present review of animal and clinical studies examines the efficacy and safety of biodegradable implants in spinal fracture intervention.

Methods: A review of the literature through March 2018 was performed using PubMed and Cochrane databases. Read More

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December 2018
2 Reads

Reemergence of West Nile Virus Infections in Southern Greece, 2017.

Am J Trop Med Hyg 2018 Dec 10. Epub 2018 Dec 10.

Department of Microbiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Greece experienced the largest European West Nile virus (WNV) outbreak in 2010 since the 1996 Romania epidemic. West Nile virus reemerged in southern Greece during 2017, after a 2-year hiatus of recorded human cases, and herein laboratory findings, clinical features, and geographic distribution of WNV cases are presented. Clinical specimens from patients with clinically suspected WNV infection were sent from local hospitals to the Microbiology Department of Medical School, National and Kapodistrian University of Athens, and were tested for the presence of specific anti-WNV antibodies and WNV RNA. Read More

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December 2018

Mesenchymal stem cells in preclinical cancer cytotherapy: a systematic review.

Stem Cell Res Ther 2018 Dec 7;9(1):336. Epub 2018 Dec 7.

Institute of Biological Research and Biotechnology, National Hellenic Research Foundation (NHRF), Konstantinou 48 Av., 116 35, Athens, Greece.

Mesenchymal stem cells (MSC) comprise a heterogeneous population of rapidly proliferating cells that can be isolated from adult (e.g., bone marrow, adipose tissue) as well as fetal (e. Read More

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December 2018

Validation study of the Functional Assessment Scale for Acute Hamstring injuries in Spanish professional soccer players.

Clin Rehabil 2018 Dec 10:269215518815540. Epub 2018 Dec 10.

1 Centro de Investigación Traslacional en Fisioterapia and Department of Pathology and Surgery, Physiotherapy Area, Miguel Hernandez University, Sant Joan d'Alacant, Spain.

Objective:: To cross-culturally adapt and validate the Functional Assessment Scale for acute hamstring injury for professional Spanish-speaking soccer players.

Design:: Clinical measurement study. Cross-cultural adaptation was conducted following international recommendations. Read More

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December 2018

Impact of short-term traffic-related air pollution on the metabolome - Results from two metabolome-wide experimental studies.

Environ Int 2018 Dec 3;123:124-131. Epub 2018 Dec 3.

MRC/PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Italian Institute for Genomic Medicine (IIGM), Turin, Italy. Electronic address:

Exposure to traffic-related air pollution (TRAP) has been associated with adverse health outcomes but underlying biological mechanisms remain poorly understood. Two randomized crossover trials were used here, the Oxford Street II (London) and the TAPAS II (Barcelona) studies, where volunteers were allocated to high or low air pollution exposures. The two locations represent different exposure scenarios, with Oxford Street characterized by diesel vehicles and Barcelona by normal mixed urban traffic. Read More

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December 2018
5 Reads

Evaluation of the prognostic value of all four HER family receptors in patients with metastatic breast cancer treated with trastuzumab: A Hellenic Cooperative Oncology Group (HeCOG) study.

PLoS One 2018 6;13(12):e0207707. Epub 2018 Dec 6.

Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece.

In the current study, we performed a complete analysis, with four different methods, of all four HER family receptors, in a series of patients with metastatic breast cancer treated with trastuzumab-based regimens and evaluated their prognostic value. Formalin-fixed paraffin-embedded tumor tissue samples were collected from 227 patients, considered to be HER2-positive when assessed at the local laboratories. We evaluated gene amplification, copy number variations (CNVs), mRNA and protein expression of all four HER family members. Read More

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December 2018
2 Reads

Mismatch repair deficiency and aberrations in the Notch and Hedgehog pathways are of prognostic value in patients with endometrial cancer.

PLoS One 2018 6;13(12):e0208221. Epub 2018 Dec 6.

Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece.

The aim of this study was to investigate the prognostic value of the Hedgehog (Gli, Patched-1, Shh, Smo) and Notch (Jag1, Notch2, Notch3) pathway members, in comparison to a panel of proteins (ER, PgR, HER2/neu, Ki67, p53, p16, PTEN and MMR) previously suggested to be involved in the pathogenesis of endometrial cancer, in association with clinical outcome and standard clinicopathological characteristics. A total of 204 patients with histological diagnosis of endometrial cancer treated from 2004 to 2013 were included. The evaluation of protein expression was assessed by immunohistochemistry. Read More

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December 2018
2 Reads

Design of Linear and Cyclic Mutant Analogues of Dirucotide Peptide (MBP) against Multiple Sclerosis: Conformational and Binding Studies to MHC Class II.

Brain Sci 2018 Dec 4;8(12). Epub 2018 Dec 4.

Department of Chemistry, University of Patras, 26500 Patras, Greece.

Background: Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system. MS is a T cell-mediated disease characterized by the proliferation, infiltration, and attack of the myelin sheath by immune cells. Previous studies have shown that cyclization provides molecules with strict conformation that could modulate the immune system. Read More

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December 2018
1 Read

Right ventricular involvement in hypertrophic cardiomyopathy: patterns and implications.

Hellenic J Cardiol 2018 Nov 30. Epub 2018 Nov 30.

Unit of Inherited Cardiovascular Diseases/Heart Center of the Young and Athletes, First Department of Cardiology, Hippokration General Hospital, National and Kapodistrian University of Athens, Greece; National Heart and Lung Institute Imperial College London, London, UK.

Although hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy worldwide, the criteria for its definition and most of the literature concern the left ventricle, confirming the theory that the right ventricle is the neglected one. Right ventricular (RV) involvement includes structural and functional changes with significant impact on clinical presentation and prognosis. The pattern of RV hypertrophy can be variable with possible dynamic obstruction. Read More

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November 2018
1 Read

Long-term changes in the structure of benthic communities: Revisiting a sampling transect in Crete after 24 years.

Mar Environ Res 2018 Nov 16. Epub 2018 Nov 16.

Marine Ecology Laboratory, Department of Biology, University of Crete, GR 70013, Heraklion, Greece; Hellenic Centre for Marine Research Institute of Marine Biology, Biotechnology and Aquaculture, GR 71003, Heraklion, Greece.

A bathymetric transect in the north coast of Crete first studied in 1989, was revisited 24 years later. Identical sampling design, season, techniques and protocols were followed in both studies in order to minimize bias in the long-term comparisons. This comprehensive macrofaunal dataset (4 stations, 2 sampling seasons, 7 replicates in each study) revealed changes in benthic diversity and community composition between the sampling periods. Read More

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November 2018

Vaccination of healthcare workers: is mandatory vaccination needed?

Expert Rev Vaccines 2018 Dec 1. Epub 2018 Dec 1.

d First Department of Pediatrics , National and Kapodistrian University of Athens , Athens , Greece.

Introduction: Vaccinations of healthcare workers (HCWs) aim to directly protect them from occupational acquisition of vaccine-preventable diseases (VPDs) and to indirectly protect their patients and the essential healthcare infrastructure. However, outbreaks due to VPDs continue to challenge healthcare facilities and HCWs are frequently traced as sources of VPDs to vulnerable patients. In addition, HCWs were disproportionately affected during the current measles outbreak in Europe. Read More

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December 2018

Exotic Tourist Destinations and Transmission of Infections by Swimming Pools and Hot Springs-A Literature Review.

Int J Environ Res Public Health 2018 Dec 3;15(12). Epub 2018 Dec 3.

Department of Biomedical Sciences, University of West Attica, 12243 Egaleo, Greece.

A growing number of people undertake international travel, and yet faster growth of such travel is expected in the tropics. Information on the hazards presented by pool and hot spring waters in tropical countries is very limited. This review aims to collate available information on pool water quality, alongside data on cases and outbreaks associated with swimming in pools in tropical regions affecting both local populations and travellers. Read More

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December 2018
1 Read

The Role of Tissue Oxygen Tension in Dengue Virus Replication.

Cells 2018 Dec 1;7(12). Epub 2018 Dec 1.

Laboratory of Molecular Virology, Hellenic Pasteur Institute (HPI), 11521 Athens, Greece.

Low oxygen tension exerts a profound effect on the replication of several DNA and RNA viruses. In vitro propagation of Dengue virus (DENV) has been conventionally studied under atmospheric oxygen levels despite that in vivo, the tissue microenvironment is hypoxic. Here, we compared the efficiency of DENV replication in liver cells, monocytes, and epithelial cells under hypoxic and normoxic conditions, investigated the ability of DENV to induce a hypoxia response and metabolic reprogramming and determined the underlying molecular mechanism. Read More

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December 2018

Discovery of common and rare genetic risk variants for colorectal cancer.

Authors:
Jeroen R Huyghe Stephanie A Bien Tabitha A Harrison Hyun Min Kang Sai Chen Stephanie L Schmit David V Conti Conghui Qu Jihyoun Jeon Christopher K Edlund Peyton Greenside Michael Wainberg Fredrick R Schumacher Joshua D Smith David M Levine Sarah C Nelson Nasa A Sinnott-Armstrong Demetrius Albanes M Henar Alonso Kristin Anderson Coral Arnau-Collell Volker Arndt Christina Bamia Barbara L Banbury John A Baron Sonja I Berndt Stéphane Bézieau D Timothy Bishop Juergen Boehm Heiner Boeing Hermann Brenner Stefanie Brezina Stephan Buch Daniel D Buchanan Andrea Burnett-Hartman Katja Butterbach Bette J Caan Peter T Campbell Christopher S Carlson Sergi Castellví-Bel Andrew T Chan Jenny Chang-Claude Stephen J Chanock Maria-Dolores Chirlaque Sang Hee Cho Charles M Connolly Amanda J Cross Katarina Cuk Keith R Curtis Albert de la Chapelle Kimberly F Doheny David Duggan Douglas F Easton Sjoerd G Elias Faye Elliott Dallas R English Edith J M Feskens Jane C Figueiredo Rocky Fischer Liesel M FitzGerald David Forman Manish Gala Steven Gallinger W James Gauderman Graham G Giles Elizabeth Gillanders Jian Gong Phyllis J Goodman William M Grady John S Grove Andrea Gsur Marc J Gunter Robert W Haile Jochen Hampe Heather Hampel Sophia Harlid Richard B Hayes Philipp Hofer Michael Hoffmeister John L Hopper Wan-Ling Hsu Wen-Yi Huang Thomas J Hudson David J Hunter Gemma Ibañez-Sanz Gregory E Idos Roxann Ingersoll Rebecca D Jackson Eric J Jacobs Mark A Jenkins Amit D Joshi Corinne E Joshu Temitope O Keku Timothy J Key Hyeong Rok Kim Emiko Kobayashi Laurence N Kolonel Charles Kooperberg Tilman Kühn Sébastien Küry Sun-Seog Kweon Susanna C Larsson Cecelia A Laurie Loic Le Marchand Suzanne M Leal Soo Chin Lee Flavio Lejbkowicz Mathieu Lemire Christopher I Li Li Li Wolfgang Lieb Yi Lin Annika Lindblom Noralane M Lindor Hua Ling Tin L Louie Satu Männistö Sanford D Markowitz Vicente Martín Giovanna Masala Caroline E McNeil Marilena Melas Roger L Milne Lorena Moreno Neil Murphy Robin Myte Alessio Naccarati Polly A Newcomb Kenneth Offit Shuji Ogino N Charlotte Onland-Moret Barbara Pardini Patrick S Parfrey Rachel Pearlman Vittorio Perduca Paul D P Pharoah Mila Pinchev Elizabeth A Platz Ross L Prentice Elizabeth Pugh Leon Raskin Gad Rennert Hedy S Rennert Elio Riboli Miguel Rodríguez-Barranco Jane Romm Lori C Sakoda Clemens Schafmayer Robert E Schoen Daniela Seminara Mitul Shah Tameka Shelford Min-Ho Shin Katerina Shulman Sabina Sieri Martha L Slattery Melissa C Southey Zsofia K Stadler Christa Stegmaier Yu-Ru Su Catherine M Tangen Stephen N Thibodeau Duncan C Thomas Sushma S Thomas Amanda E Toland Antonia Trichopoulou Cornelia M Ulrich David J Van Den Berg Franzel J B van Duijnhoven Bethany Van Guelpen Henk van Kranen Joseph Vijai Kala Visvanathan Pavel Vodicka Ludmila Vodickova Veronika Vymetalkova Korbinian Weigl Stephanie J Weinstein Emily White Aung Ko Win C Roland Wolf Alicja Wolk Michael O Woods Anna H Wu Syed H Zaidi Brent W Zanke Qing Zhang Wei Zheng Peter C Scacheri John D Potter Michael C Bassik Anshul Kundaje Graham Casey Victor Moreno Goncalo R Abecasis Deborah A Nickerson Stephen B Gruber Li Hsu Ulrike Peters

Nat Genet 2018 Dec 3. Epub 2018 Dec 3.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0. Read More

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December 2018
8 Reads
29.352 Impact Factor

First evidence of ingested plastics by a high commercial shrimp species (Plesionika narval) in the eastern Mediterranean.

Mar Pollut Bull 2018 Nov 28;136:472-476. Epub 2018 Sep 28.

Hellenic Centre for Marine Research, Institute of Marine Biological Resources and Inland Waters, 46.7km Athens-Sounio, Anavissos, attiki 19013, Greece.

This study provides the first evidence of nylon filament occurrence in the stomach of an economically important target shrimp species in the Mediterranean Sea, Plesionika narval (Fabricius, 1787). Samples were collected monthly from November 2014 to October 2015 from shallow (10-30 m) and deeper waters (150-170 m). The occurrence of plastics in the stomachs of the Narwal shrimp was 5. Read More

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November 2018

Floating plastics in Adriatic waters (Mediterranean Sea): From the macro- to the micro-scale.

Mar Pollut Bull 2018 Nov 22;136:341-350. Epub 2018 Sep 22.

Mediterranean Information Office for Environment, Culture and Sustainable Development (MIO-ECSDE), Greece.

Macro- and microplastics abundances were determined in the Adriatic Sea following the MSFD TG10 protocol. The studied areas included populated gulfs, river outlets and offshore waters in five Adriatic countries. The use of small ships enabled us to detect small sized plastics (2. Read More

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November 2018

Water temperature modifies the acute stress response of European sea bass, Dicentrarchus labrax L. (1758).

J Therm Biol 2018 Dec 13;78:84-91. Epub 2018 Sep 13.

University of Crete, Department of Biology, 70013 Heraklion, Greece.

The effects of water temperature (15, 20 and 25 °C) on the stress response of European sea bass, Dicentrarchus labrax, were studied. Blood and water samples were collected prior and at 0.5, 1, 2, 4 and 8 h post-stress for hormonal and biochemical analysis. Read More

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December 2018

Impact of the uncontrolled leakage of leachate from a municipal solid waste landfill on soil in a cultivated-calcareous environment.

Waste Manag 2018 Dec 16;82:51-61. Epub 2018 Oct 16.

West Azarbaijan Agricultural Researches Center and Natural Resources, Urmia, Islamic Republic of Iran.

The heavy metal pollution generated by landfill leachate becomes increasingly concerning due to its potential to impact human health through the food chain. In the present study, the accumulation and potential health risk of heavy metals (Zn, Cu, Cd, Pb, and Ni) were investigated in a calcareous soil -wheat system affected by an uncontrolled landfill leachate. The results showed soils were significantly enriched by both the available and total fractions of the metals in the sequences of Zn > Pb > Ni > Cd > Cu and Cd > Zn > Ni > Pb > Cu, respectively. Read More

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December 2018
3 Reads

Risk prediction for estrogen receptor-specific breast cancers in two large prospective cohorts.

Breast Cancer Res 2018 Dec 3;20(1):147. Epub 2018 Dec 3.

Nutritional Methodology and Biostatistics Group, Nutrition and Metabolism Section, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372, Lyon Cedex 08, France.

Background: Few published breast cancer (BC) risk prediction models consider the heterogeneity of predictor variables between estrogen-receptor positive (ER+) and negative (ER-) tumors. Using data from two large cohorts, we examined whether modeling this heterogeneity could improve prediction.

Methods: We built two models, for ER+ (Model) and ER- tumors (Model), respectively, in 281,330 women (51% postmenopausal at recruitment) from the European Prospective Investigation into Cancer and Nutrition cohort. Read More

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December 2018
1 Read

Polyurethane, epoxy resin and polydimethylsiloxane altered biofilm formation and mussel settlement.

Chemosphere 2018 Nov 20;218:599-608. Epub 2018 Nov 20.

International Research Center for Marine Biosciences, Ministry of Science and Technology, Shanghai Ocean University, Shanghai, China; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, China; National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, China. Electronic address:

In many environments, biofilms are a major mode and an emergent form of microbial life. Biofilms play crucial roles in biogeochemical cycling and invertebrate recruitment in marine environments. However, relatively little is known about how marine biofilms form on different substrata and about how these biofilms impact invertebrate recruitment. Read More

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November 2018
3.340 Impact Factor

Low prevalence of rheumatoid arthritis among patients with pre-existing type 2 diabetes mellitus.

Ann Transl Med 2018 Oct;6(20):399

First Department of Propaedeutic Internal Medicine, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece.

Background: Type 2 diabetes mellitus (T2DM) is a non-autoimmune disease characterized by chronic hyperglycemia and increased non-enzymatic glycation of amino groups. Glycation occurs through a series of events eventually leading to the formation of irreversible "advanced glycation end-products" (AGEs). AGEs may affect the function of long-lived proteins, including cytokines, immunoglobulins and their receptors, resulting in a "less active" immune system. Read More

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October 2018
4 Reads

Gemcitabine Combined with the mTOR Inhibitor Temsirolimus in Patients with Locally Advanced or Metastatic Pancreatic Cancer. A Hellenic Cooperative Oncology Group Phase I/II Study.

Target Oncol 2018 Nov 28. Epub 2018 Nov 28.

Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background: The prognosis of patients with advanced pancreatic cancer is dismal, and there is a need for novel and effective treatments.

Objectives: Tο determine the maximum tolerated dose (MTD) and dose-limiting toxicities (DLTs) of a novel gemcitabine (G) and temsirolimus (T) combination (phase I) and estimate the 6-month progression-free survival (PFS) in patients treated with the T + G combination (phase II).

Patients And Methods: Eligible patients with histologically confirmed inoperable or metastatic pancreatic carcinoma (MPC) were entered into the trial. Read More

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November 2018

The larva of Hydropsyche perseus Malicky 2001, endemic to Kerkyra (Corfu) Island, including a key for the known Hydropsyche larvae of the Greek islands.

Zootaxa 2018 Oct 24;4504(2):296-300. Epub 2018 Oct 24.

Institute of Marine Biological Resources and Inland Waters, Hellenic Centre for Marine Research, 46.7 km Athens-Sounio Av., Anavissos 19013, Greece..

The larva of Hydropsyche perseus Malicky 2001, endemic species of Kerkyra Island (Corfu), Greece, is described for the first time. The diagnostic features of the species are described and illustrated, and some information regarding its ecology is included. In addition, a tabular key for larvae of the known Hydropsyche species of the Greek Islands is provided. Read More

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October 2018

The larvae of Rhyacophila tsurakiana Malicky 1984, Rhyacophila gudrunae Malicky 1972, and Rhyacophila biegelmeieri Malicky 1984, including an update for the larval key to the Greek species of genus Rhyacophila Stephens 1836 (Rhyacophilidae, Trichoptera).

Zootaxa 2018 Oct 29;4508(1):85-100. Epub 2018 Oct 29.

Department of Limnology and Bio-Oceanography, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria..

Based on adults, mature pupae, and larvae sampled at the same sites on mainland Greece and on the Greek islands of Kerkyra (Corfu) and Crete, the previously unknown larval stages of Rhyacophila tsurakiana Malicky 1984, R. gudrunae Malicky 1972, and R. biegelmeieri Malicky 1984 could be associated and identified. Read More

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October 2018
3 Reads

The larva of Rhyacophila palmeni McLachlan 1879 (Trichoptera: Rhyacophilidae) from Greece and Kosovo with notes on ecology and zoogeography including a key to the known Greek Rhyacophila larvae.

Zootaxa 2018 Nov 5;4514(1):97-106. Epub 2018 Nov 5.

Institute of Marine Biological Recourses and Inland Waters, Hellenic Centre for Marine Research, 46.7km Athens-Sounio Av., 19013 Anavissos, Attica, Greece..

The larva of Rhyacophila palmeni McLachlan 1879 is described, based on material from Greece and Kosovo. The diagnostic features of the species are discussed and illustrated, and some information on its ecology and distribution are included. In addition, diagnostic characters for larvae of the known Greek Rhyacophila species are provided. Read More

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November 2018

Reproductive factors, exogenous hormone use and risk of B-cell non-Hodgkin lymphoma in a cohort of women from the European Prospective Investigation into Cancer and Nutrition.

Am J Epidemiol 2018 Nov 27. Epub 2018 Nov 27.

Unit of Molecular Epidemiology and Genetics in Infections and Cancer. Cancer Epidemiology Research Programme. Bellvitge Biomedical Research Institute (IDIBELL). Catalan Institute of Oncology.

The role of hormonal factors in lymphoid neoplasms etiology remains unclear. Previous studies have yielded conflicting results, been underpowered to assess many lymphoma subtypes, or lacked detailed information on relevant exposures. Within the European Prospective Investigation into Cancer and Nutrition cohort, we analyzed comprehensive data collected at baseline (1992-2000) on reproductive factors and exogenous hormone use among 343,458 women, including 1,427 incident B-cell non-Hodgkin lymphomas (NHL) and its major subtypes identified after a mean follow-up of 14 years (through 2015). Read More

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November 2018
5 Reads

Prognostic significance of tumor genotypes and CD8+ infiltrates in stage I-III colorectal cancer.

Oncotarget 2018 Nov 2;9(86):35623-35638. Epub 2018 Nov 2.

Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background: We explored the clinical significance of tumor genotypes and immunophenotypes in non-metastatic colorectal cancer (CRC).

Methods: In primary tumors (paraffin blocks) from 412 CRC patients treated with adjuvant chemotherapy, we examined pathogenic mutations (panel NGS; 347 informative); mismatch repair (MMR) immunophenotype (360 informative); and CD8+ lymphocyte density (high - low; 412 informative). The primary outcome measure was disease-free survival (DFS). Read More

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November 2018
1 Read

Acquired Gerbode type defect after bioprosthetic aortic valve replacement.

Hellenic J Cardiol 2018 Nov 21. Epub 2018 Nov 21.

Cardiology Department, Asklepeion Voulas General Hospital, Voula, Athens, Greece.

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November 2018

Orthosteric and/or Allosteric Binding of α-Conotoxins to Nicotinic Acetylcholine Receptors and Their Models.

Mar Drugs 2018 Nov 22;16(12). Epub 2018 Nov 22.

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, 117997 Moscow, Russia.

α-Conotoxins from snails are capable of distinguishing muscle and neuronal nicotinic acetylcholine receptors (nAChRs). α-Conotoxin RgIA and αO-conotoxin GeXIVA, blocking neuronal α9α10 nAChR, are potential analgesics. Typically, α-conotoxins bind to the orthosteric sites for agonists/competitive antagonists, but αO-conotoxin GeXIVA was proposed to attach allosterically, judging by electrophysiological experiments on α9α10 nAChR. Read More

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November 2018
3 Reads
2.853 Impact Factor

Decellularized Human Umbilical Artery Used as Nerve Conduit.

Bioengineering (Basel) 2018 Nov 21;5(4). Epub 2018 Nov 21.

Hellenic Cord Blood Bank, Biomedical Research Foudation Academy of Athens, 4 Soranou Ephessiou Street, 11527 Athens, Greece.

Treatment of injuries to peripheral nerves after a segmental defect is one of the most challenging surgical problems. Despite advancements in microsurgical techniques, complete recovery of nerve function after repair has not been achieved. The purpose of this study was to evaluate the use of the decellularized human umbilical artery (hUA) as nerve guidance conduit. Read More

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November 2018
4 Reads

Physiotherapist perceptions of optimal sitting and standing posture.

Musculoskelet Sci Pract 2018 Nov 17;39:24-31. Epub 2018 Nov 17.

Faculty of Physical Education and Sport Sciences, University of Thessaly, Trikala, Greece.

Background: Assessment of, and advice about, spinal posture is common when people with spinal pain present to physiotherapists. Most descriptions regarding optimal spinal posture have been qualitative in nature.

Objectives: To determine the beliefs of physiotherapists regarding optimal sitting and standing posture. Read More

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November 2018
3 Reads

Noggin levels in nonalcoholic fatty liver disease: the effect of vitamin E treatment.

Hormones (Athens) 2018 Dec 22;17(4):573-579. Epub 2018 Nov 22.

Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Aim: The evaluation of (a) noggin levels in patients with simple steatosis (SS) vs. nonalcoholic steatohepatitis (NASH) vs. controls, and (b) the effect of combined spironolactone plus vitamin E vs. Read More

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December 2018
3 Reads

Knowledge and attitudes of nurses in a major public hospital in Cyprus towards pressure ulcer prevention.

J Tissue Viability 2018 Nov 10. Epub 2018 Nov 10.

European University Cyprus, Cyprus.

Study Aim: The main aim of the study was to identify the knowledge and attitudes of nurses towards pressure ulcer prevention in a major public hospital in Cyprus.

Material And Methods: A descriptive and cross-sectional study design was used to collect the data between December 2014 and February 2015, the sample consisted of n = 102 nurses employed in a major public hospital in Cyprus. Customised and standardised Pressure Ulcer Knowledge Test and an attitudes Likert questionnaire was used to investigate both parameters. Read More

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November 2018
9 Reads

Tiny Rare-Earth Fluoride Nanoparticles Activate Tumour Cell Growth via Electrical Polar Interactions.

Nanoscale Res Lett 2018 Nov 21;13(1):370. Epub 2018 Nov 21.

National Hellenic Research Foundation, Theoretical and Physical Chemistry Institute, 48 Vassileos Constantinou Avenue, 11635, Athens, Greece.

Localised extracellular interactions between nanoparticles and transmembrane signal receptors may well activate cancer cell growth. Herein, tiny LaF and PrF nanoparticles in DMEM+FBS suspensions stimulated tumour cell growth in three different human cell lines (A549, SW837 and MCF7). Size distribution of nanoparticles, activation of AKT and ERK signalling pathways and viability tests pointed to mechanical stimulation of ligand adhesion binding sites of integrins and EGFR via a synergistic action of an ensemble of tiny size nanoparticles (< 10 nm). Read More

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November 2018
3 Reads
2.779 Impact Factor

Personal care products reconnaissance in EVROTAS river (Greece): Water-sediment partition and bioaccumulation in fish.

Sci Total Environ 2019 Feb 2;651(Pt 2):3079-3089. Epub 2018 Oct 2.

Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research of the Spanish Council for Scientific Research IDAEA-CSIC, C/Jordi Girona 18-26, 08034 Barcelona, Spain; Catalan Institute for Water Research (ICRA), Parc Científic i Tecnològic de la Universitat de Girona, C/Emili Grahit, 101 Edifici H2O, 17003 Girona, Spain.

Twenty-six common ingredients of personal care products (PCPs) in water, sediment and fish from the Evrotas River (Greece) were investigated. Water sample analysis revealed the occurrence of twenty PCPs at concentrations ranging from 2.8 to 2031. Read More

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February 2019
3 Reads

Exploring causality of the association between smoking and Parkinson's disease.

Int J Epidemiol 2018 Nov 20. Epub 2018 Nov 20.

School of Public Health, Imperial College London, London, UK.

Background: The aim of this paper is to investigate the causality of the inverse association between cigarette smoking and Parkinson's disease (PD). The main suggested alternatives include a delaying effect of smoking, reverse causality or an unmeasured confounding related to a low-risk-taking personality trait.

Methods: A total of 715 incident PD cases were ascertained in a cohort of 220 494 individuals from NeuroEPIC4PD, a prospective European population-based cohort study including 13 centres in eight countries. Read More

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November 2018
5 Reads

The Beneficial Endophytic Fungus Strain K Alters Tomato Responses Against Spider Mites to the Benefit of the Plant.

Front Plant Sci 2018 6;9:1603. Epub 2018 Nov 6.

Laboratory of Plant and Environmental Biotechnology, Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece.

Beneficial microorganisms are known to promote plant growth and confer resistance to biotic and abiotic stressors. Soil-borne beneficial microbes in particular have shown potential in protecting plants against pathogens and herbivores via the elicitation of plant responses. In this study, we evaluated the role of strain K (FsK) in altering plant responses to the two spotted spider mite in tomato. Read More

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November 2018
3 Reads
3.637 Impact Factor