6,380 results match your criteria Hellenic journal of cardiology : HJC = Hell?nik? kardiologik? epithe?r?s?[Journal]


Should we abandon the term〝lone atrial fibrillation〞?

Hellenic J Cardiol 2019 Apr 17. Epub 2019 Apr 17.

(a)Heart Center, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P. R. China. Electronic address:

Characterized by lack of evidence of structural heart disease or any secondary causes of atrial fibrillation (AF), "lone AF" used to represent a unique subtype of AF among the young individuals who were under the age of 60. Despite the longstanding definition has been proposed for years, the diagnostic criteria for "lone AF" remain ambiguous. As more contributing factors causing AF are recognized gradually, the validity of the term of 'lone AF' is in question. Read More

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http://dx.doi.org/10.1016/j.hjc.2019.04.005DOI Listing

The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents.

Antioxidants (Basel) 2019 Apr 18;8(4). Epub 2019 Apr 18.

Department of Applied Sciences, Northumbria University, Newcastle Upon Tyne NE1 8ST, UK.

Many studies have shown evidence in support of the beneficial effects of phytochemicals in preventing chronic diseases, including cancer. Among such phytochemicals, sulphur-containing compounds (e.g. Read More

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http://dx.doi.org/10.3390/antiox8040106DOI Listing

The mitral valve in hypertrophic cardiomyopathy: a three-dimensional transesophageal study.

Hellenic J Cardiol 2019 Apr 16. Epub 2019 Apr 16.

1st Department of Cardiology, Hippokratio Hospital, Medical School University of Athens, 114, Vas. Sophias Av., GR11527, Athens, Greece. Electronic address:

Background: It is reported that the mitral valve (MV) in hypertrophic cardiomyopathy (HCM) has structural abnormalities.

Purpose: To assess the MV in HCM patients using Three-Dimensional Transesophageal Echocardiography (3DTEE).

Methods: Transthoracic and 3DTEE studies focused on the mitral valve were performed prospectively in 21 HCM patients with obstruction (Group I), 37 HCM patients without obstruction (Group II) and 28 controls (Group III). Read More

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http://dx.doi.org/10.1016/j.hjc.2019.04.004DOI Listing

Latitudinal variation in soil nematode communities under climate warming-related range-expanding and native plants.

Glob Chang Biol 2019 Apr 19. Epub 2019 Apr 19.

Netherlands Institute of Ecology, PO Box 50, 6700 AB, Wageningen, Netherlands.

Current climate change has led to latitudinal and altitudinal range expansions of numerous species. During such range expansions, plant species are expected to experience changes in interactions with other organisms, especially with belowground biota that have a limited dispersal capacity. Nematodes form a key component of the belowground food web as they include bacterivores, fungivores, omnivores and root herbivores. Read More

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http://dx.doi.org/10.1111/gcb.14657DOI Listing

A single enzyme PCR-RFLP assay targeting V1-V3 region of 16S rRNA gene for direct identification of Alicyclobacillus acidoterrestris from other Alicyclobacillus species.

J Appl Genet 2019 Apr 19. Epub 2019 Apr 19.

Department of Food Science and Human Nutrition, Faculty of Foods, Biotechnology and Development, Laboratory of Microbiology and Biotechnology of Foods, Agricultural University of Athens, Iera Odos 75, 11855, Athens, Greece.

Alicyclobacillus acidoterrestris is considered to be one of the most important target microorganisms in quality control of heat-processed acidic foods. This species can cause spoilage by forming spores with very high heat resistance; however, no gas production or visible changes occur in the contaminated product during storage. Thus, the differentiation of A. Read More

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http://dx.doi.org/10.1007/s13353-019-00498-8DOI Listing

Detection of tetrodotoxins in juvenile pufferfish Lagocephalus sceleratus (Gmelin, 1789) from the North Aegean Sea (Greece) by an electrochemical magnetic bead-based immunosensing tool.

Food Chem 2019 Aug 29;290:255-262. Epub 2019 Mar 29.

IRTA, Ctra. Poble Nou, km 5.5, 43540 Sant Carles de la Ràpita, Tarragona, Spain. Electronic address:

Two small Lagocephalus sceleratus juveniles were captured in picarel targeting catches from North Aegean Sea (Greece) in the autumn of 2017. An electrochemical immunosensing tool using magnetic beads as immobilisation support was developed and applied to the rapid screening of tetrodotoxins (TTXs), potent neurotoxins that constitute a food safety hazard when present in seafood. This tool revealed the presence of TTXs in both individuals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03088146193064
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http://dx.doi.org/10.1016/j.foodchem.2019.03.148DOI Listing
August 2019
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Epidemiology of Taenia saginata taeniosis/cysticercosis: a systematic review of the distribution in central and western Asia and the Caucasus.

Parasit Vectors 2019 Apr 18;12(1):175. Epub 2019 Apr 18.

Centre of Excellence for Food and Vector-borne Zoonoses, Institute for Medical Research, University of Belgrade, Dr Subotića 4, Belgrade, 11000, Serbia.

Background: The zoonotic parasite Taenia saginata transmits between humans, the definitive host (causing taeniosis), and bovines as the intermediate host (causing cysticercosis). Central and western Asia and the Caucasus have large cattle populations and beef consumption is widespread. However, an overview of the extent of human T. Read More

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http://dx.doi.org/10.1186/s13071-019-3438-3DOI Listing

Resin as Yeast Immobilization Support for Alcoholic Fermentation.

Foods 2019 Apr 17;8(4). Epub 2019 Apr 17.

Food Biotechnology Group, Department of Chemistry, University of Patras, GR-26500 Patras, Greece.

A natural resin retrieved from tree was evaluated as an immobilization carrier of AXAZ-1 cells targeting successive fermentation batches of sugar synthetic mediums. Fermentation times below 54 h were recorded at temperatures 28-14 °C. In total, 147 compounds were detected using gas chromatography-mass spectrometry (GC-MS) analysis, including alcohols, esters, ketones, aldehydes, acids, and terpenes. Read More

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http://dx.doi.org/10.3390/foods8040127DOI Listing

Thermodynamics of force-induced B-DNA melting: Single-strand discreteness matters.

Phys Rev E 2019 Mar;99(3-1):032404

Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, Vasileos Constantinou 48, 116 35 Athens, Greece and Fachbereich Physik, Universität Konstanz, 78457 Konstanz, Germany.

Overstretching of B-DNA is currently understood as force-induced melting. Depending on the geometry of the stretching experiment, the force threshold for the overstretching transition is around 65 or 110 pN. Although the mechanisms behind force-induced melting have been correctly described by Rouzina and Bloomfield [Biophys. Read More

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http://dx.doi.org/10.1103/PhysRevE.99.032404DOI Listing

Leishmania infantum LeIF and its recombinant polypeptides induce the maturation of dendritic cells in vitro: an insight for dendritic cells based vaccine.

Immunol Lett 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Molecular Epidemiology and Experimental Pathology, Institut Pasteur de Tunis, Université Tunis El Manar, 13 Place Pasteur, BP 74, 1002 Tunis-Belvedère, Tunisia. Electronic address:

We previously showed that recombinant Leishmania infantum eukaryotic initiation factor (LieIF) was able to induce the secretion of cytokines IL-12, IL-10 and TNF-α by human monocytes. In this study, we explored in vitro the potential of LieIF to induce phenotypic maturation and functional differentiation of murine bone - marrow derived dendritic cells (BM-DCs). Moreover, in order to identify potential immunnomodulatory regions of LieIF, eight recombinant overlapping protein fragments covering the whole amino acid sequence ofprotein; were constructed and assessed in vitro for their ability to induce maturation of BM-DCs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01652478183041
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http://dx.doi.org/10.1016/j.imlet.2019.04.001DOI Listing
April 2019
1 Read

The Economic Burden of Asthma in Greece: A Cross-Sectional Study.

Appl Health Econ Health Policy 2019 Apr 17. Epub 2019 Apr 17.

EVROSTON LP, Chatzigianni Mexi 5, 115 28, Athens, Greece.

Background: The high prevalence rates of asthma worldwide and the chronic nature of the disease make asthma a major cause of morbidity, imposing a significant socio-economic burden in many countries. Specifically in Greece, the self-reported prevalence of asthma reached 9% in 2017.

Objectives: The objective of this study was to estimate the total management cost of asthma in Greece and its potential determinants. Read More

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http://link.springer.com/10.1007/s40258-019-00469-4
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http://dx.doi.org/10.1007/s40258-019-00469-4DOI Listing
April 2019
2 Reads

Epidemiology of viral infections among children undergoing hematopoietic stem cell transplant: Α prospective single- center study.

Transpl Infect Dis 2019 Apr 16:e13095. Epub 2019 Apr 16.

Pediatric Clinic, "P & A Kyriakou" Children's Hospital, National and Kapodistrian University of Athens, Faculty of Nursing, Athens, Greece.

Background: Viral infections are a significant cause of morbidity and mortality in pediatric transplant populations. We analyzed the epidemiology of viral infections in pediatric hematopoietic stem cell transplant (HSCT) patients, including their incidence, associated risk factors, and outcome.

Methods: In a prospective study from September 2011 to September 2015 blood, urine and stool specimens were monitored weekly from transplantation to day 100 or after if clinically suspected, by use of real-time polymerase chain reaction. Read More

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http://dx.doi.org/10.1111/tid.13095DOI Listing
April 2019
1 Read

Genes associated with Parkinson's disease respond to increasing polychlorinated biphenyl levels in the blood of healthy females.

Environ Pollut 2019 Apr 8;250:107-117. Epub 2019 Apr 8.

Department of Toxicogenomics, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands, 6229, ER Maastricht, the Netherlands.

Polychlorinated biphenyls (PCBs) are a class of widespread environmental pollutants, commonly found in human blood, that have been suggested to be linked to the occurrence of sporadic Parkinson's disease (PD). It has been reported that some non-coplanar PCBs accumulate in the brains of female PD patients. To improve our understanding of the association between PCB exposure and PD risk we have applied whole transcriptome gene expression analysis in blood cells from 594 PCB-exposed subjects (369 female, 225 male). Read More

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http://dx.doi.org/10.1016/j.envpol.2019.04.005DOI Listing
April 2019
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In Vivo Phenotyping of Familial Parkinson's Disease with Human Induced Pluripotent Stem Cells: A Proof-of-Concept Study.

Neurochem Res 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Cellular and Molecular Neurobiology - Stem Cells, Department of Neurobiology, Hellenic Pasteur Institute, 127 Vassilissis Sofias Avenue, 11521, Athens, Greece.

Parkinson's disease (PD) is the second most common neurodegenerative disorder. We have previously developed a disease-in-a-dish model for familial PD using induced pluripotent stem cells (iPSCs) from two patients carrying the p.A53T α-synuclein (αSyn) mutation. Read More

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http://dx.doi.org/10.1007/s11064-019-02781-wDOI Listing

High Consistency of Structure-Based Design and X-Ray Crystallography: Design, Synthesis, Kinetic Evaluation and Crystallographic Binding Mode Determination of Biphenyl--acyl-β-d-Glucopyranosylamines as Glycogen Phosphorylase Inhibitors.

Molecules 2019 Apr 3;24(7). Epub 2019 Apr 3.

Department of Biochemistry and Biotechnology, University of Thessaly, Biopolis, 41500 Larissa, Greece.

Structure-based design and synthesis of two biphenyl--acyl-β-d-glucopyranosylamine derivatives as well as their assessment as inhibitors of human liver glycogen phosphorylase (hlGPa, a pharmaceutical target for type 2 diabetes) is presented. X-ray crystallography revealed the importance of structural water molecules and that the inhibitory efficacy correlates with the degree of disturbance caused by the inhibitor binding to a loop crucial for the catalytic mechanism. The in silico-derived models of the binding mode generated during the design process corresponded very well with the crystallographic data. Read More

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http://dx.doi.org/10.3390/molecules24071322DOI Listing

Psychometric Evaluation of the Nine-Item Problematic Internet Use Questionnaire (PIUQ-9) in Nine European Samples of Internet Users.

Front Psychiatry 2019 22;10:136. Epub 2019 Mar 22.

Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary.

The nine-item Problematic Internet Use Questionnaire (PIUQ-9) is a brief self-report screening instrument for problematic internet use. The main objective of the present study was to explore the psychometric properties of the PIUQ-9 among nine different language-based samples of European internet users (Italian, German, French, Polish, Turkish, Hungarian, English, and Greek). The total sample comprised 5,593 internet users (38. Read More

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https://www.frontiersin.org/article/10.3389/fpsyt.2019.00136
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http://dx.doi.org/10.3389/fpsyt.2019.00136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448041PMC
March 2019
1 Read

Data from the cardiac catheterization laboratories in Greece.

Hellenic J Cardiol 2019 Apr 10. Epub 2019 Apr 10.

Dept. of Cardiology, University Hospital of Heraklion, Crete, Greece.

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http://dx.doi.org/10.1016/j.hjc.2019.04.003DOI Listing
April 2019
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Corticosteroids for pericarditis: a warning but don't throw the baby out with the bathwater.

Hellenic J Cardiol 2019 Apr 10. Epub 2019 Apr 10.

First Cardiology Department, Hippokration General Hospital, National and Kapodistrian University of Athens, Greece.

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http://dx.doi.org/10.1016/j.hjc.2019.04.002DOI Listing
April 2019
4 Reads

Biochemical pathways mediated by KLK6 protease in breast cancer.

Mol Oncol 2019 Apr 13. Epub 2019 Apr 13.

Department of Pharmacy, School of Health Sciences, University of Patras, Rion-Patras, 265 04, Greece.

KLK6 is a serine protease normally expressed in mammary tissue, and aberrantly regulated in breast cancer. At physiological levels, KLK6 functions as a suppressor of breast cancer, while its aberrant overexpression (>50-fold higher than normal) is characteristic of a subset of breast cancers and has been linked to accelerated growth of primary breast tumors in SCID mice (Pampalakis et al. Cancer Res 2009). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/1878-0261.12
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http://dx.doi.org/10.1002/1878-0261.12493DOI Listing
April 2019
1 Read

Complete Genome Sequence of Vibrio anguillarum Nontailed Bacteriophage NO16.

Microbiol Resour Announc 2019 Apr 11;8(15). Epub 2019 Apr 11.

Marine Biological Section, University of Copenhagen, Helsingør, Denmark

A rare nontailed virus designated NO16 was isolated against , a major aquaculture pathogen for both fish and shellfish. Here, we announce the 10,594-bp genome sequence of phage NO16 with a 23-gene content. Read More

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http://dx.doi.org/10.1128/MRA.00020-19DOI Listing

Tracing new atherogenic properties of PCSK9. Another insight into the pathogenesis of atherosclerosis "the Minotaur's labyrinth".

Hellenic J Cardiol 2019 Apr 8. Epub 2019 Apr 8.

Second Department of Cardiology, University General Hospital, "Attikon", Athens, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.hjc.2019.04.001DOI Listing

Multi-use of the sea: A wide array of opportunities from site-specific cases across Europe.

PLoS One 2019 11;14(4):e0215010. Epub 2019 Apr 11.

CIBIO - Research Centre in Biodiversity and Genetic Resources/InBIO - Associate Laboratory, University of the Azores, Ponta Delgada, The Azores, Portugal.

The concept of multi-use of the sea has gained popularity in recent years as a result of ocean space (coastal areas and regions with relatively small sea space in particular) becoming increasingly crowded due to the development of the maritime economy. Competing claims for space can be a source of conflict, however this may also lead to mutual benefits for different users when sustainable combinations are sought. Despite increasing European-wide efforts, on-the-ground knowledge and practice of multi-use are still limited. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215010PLOS

Retraction Note to: Juvenile-onset myasthenia gravis: autoantibody status, clinical characteristics and genetic polymorphisms.

J Neurol 2019 Apr 11. Epub 2019 Apr 11.

Department of Clinical Medicine, University of Bergen, Bergen, Norway.

The Joint Editors-in-Chief have retracted this article [1] at the request of the University of Bergen and the Norwegian Board of Health Supervision. Read More

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http://dx.doi.org/10.1007/s00415-019-09292-2DOI Listing

Spatial Variability of Antarctic Surface Snow Bacterial Communities.

Front Microbiol 2019 26;10:461. Epub 2019 Mar 26.

Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University at Newcastle, Newcastle upon Tyne, United Kingdom.

It was once a long-held view that the Antarctic was a pristine environment with low biomass, low biodiversity and low rates of microbial activity. However, as the intensity of scientific investigation has increased, so these views have started to change. In particular, the role and impact of human activity toward indigenous microbial communities has started to come under more intense scrutiny. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00461
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http://dx.doi.org/10.3389/fmicb.2019.00461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443967PMC
March 2019
5 Reads

Mediation analysis of the alcohol-postmenopausal breast cancer relationship by sex hormones in the EPIC Cohort.

Int J Cancer 2019 Apr 10. Epub 2019 Apr 10.

Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69008 Lyon, France.

Alcohol consumption is associated with higher risk of breast cancer (BC); however, the biological mechanisms underlying this association are not fully elucidated, particularly the extent to which this relationship is mediated by sex hormone levels. Circulating concentrations of estradiol, testosterone, their free fractions and sex-hormone binding globulin (SHBG), were examined in 430 incident BC cases and 645 matched controls among alcohol-consuming postmenopausal women nested within the European Prospective Investigation into Cancer and Nutrition. Mediation analysis was applied to assess whether individual hormone levels mediated the relationship between alcohol intake and BC risk. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32324
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http://dx.doi.org/10.1002/ijc.32324DOI Listing
April 2019
5 Reads

Mortality attributable to seasonal influenza in Greece, 2013 to 2017: variation by type/subtype and age, and a possible harvesting effect.

Euro Surveill 2019 Apr;24(14)

4th Department of Internal Medicine, Attikon University Hospital, University of Athens Medical School, Athens, Greece.

IntroductionEstimating the contribution of influenza to excess mortality in the population presents substantial methodological challenges.AimIn a modelling study we combined environmental, epidemiological and laboratory surveillance data to estimate influenza-attributable mortality in Greece, over four seasons (2013/14 to 2016/17), specifically addressing the lag dimension and the confounding effect of temperature.MethodsAssociations of influenza type/subtype-specific incidence proxies and of daily mean temperature with mortality were estimated with a distributed-lag nonlinear model with 30 days of maximum lag, separately by age group (all ages, 15-64 and ≥ 65 years old). Read More

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https://www.eurosurveillance.org/content/10.2807/1560-7917.E
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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.14.1800118DOI Listing
April 2019
2 Reads

Global ecological impacts of marine exotic species.

Nat Ecol Evol 2019 Apr 8. Epub 2019 Apr 8.

Red Sea Research Centre, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.

Exotic species are a growing global ecological threat; however, their overall effects are insufficiently understood. While some exotic species are implicated in many species extinctions, others can provide benefits to the recipient communities. Here, we performed a meta-analysis to quantify and synthesize the ecological effects of 76 exotic marine species (about 6% of the listed exotics) on ten variables in marine communities. Read More

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http://dx.doi.org/10.1038/s41559-019-0851-0DOI Listing

Tuning Carbon Dots' Optoelectronic Properties with Polymers.

Polymers (Basel) 2018 Nov 27;10(12). Epub 2018 Nov 27.

Department of Materials Science & Engineering, University of Ioannina, GR-45110 Ioannina, Greece.

Due to their unique properties of photoluminescence, biocompatibility, photostability, ease of preparing, and low cost, carbon dots have been studied extensively over the last decade. Soon after their discovery, it was realized that their main optical attributes may be protected, enhanced, and tuned upon proper surface passivation or functionalization. Therefore, up to date, numerous polymers have been used for these purposes, resulting to higher-quality carbon dots regarding their quantum yield or further emission-related aspects and compared to the primitive, bare ones. Read More

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http://dx.doi.org/10.3390/polym10121312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401920PMC
November 2018

Anatomic Characteristics of the Distal Oblique Bundle of the Interosseous Membrane of the Forearm.

Cureus 2019 Jan 25;11(1):e3964. Epub 2019 Jan 25.

Surgery, Medical School of National and Kapodistrian University of Athens, Athens, GRC.

The distal oblique bundle of the forearm is a structure that has been under vigorous investigation for the past decade. It is part of the distal interosseous membrane (DIOM) and seems to have an important stabilizing effect in the distal radioulnar joint. In this essay, we have tried to summarize the anatomical characteristics of the structure. Read More

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http://dx.doi.org/10.7759/cureus.3964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436668PMC
January 2019

Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development.

Oncotarget 2019 Mar 5;10(19):1760-1774. Epub 2019 Mar 5.

Biomedical Data Science Department, Dartmouth College, Hanover, NH, USA.

The development of cancer is driven by the accumulation of many oncogenesis-related genetic alterations and tumorigenesis is triggered by complex networks of involved genes rather than independent actions. To explore the epistasis existing among oncogenesis-related genes in lung cancer development, we conducted pairwise genetic interaction analyses among 35,031 SNPs from 2027 oncogenesis-related genes. The genotypes from three independent genome-wide association studies including a total of 24,037 lung cancer patients and 20,401 healthy controls with Caucasian ancestry were analyzed in the study. Read More

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http://dx.doi.org/10.18632/oncotarget.26678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442994PMC
March 2019
1 Read
6.359 Impact Factor

Emergence of West Nile virus lineage 2 belonging to the Eastern European subclade, Greece.

Arch Virol 2019 Apr 5. Epub 2019 Apr 5.

General Directorate of Public Health and Social Care of Region of Eastern Macedonia and Thrace, Komotini, Greece.

West Nile virus (WNV) emerged in Greece in 2010 and since then human outbreaks occurred every year except 2015 and 2016. An early start and prolonged WNV transmission season was observed in 2018 with a record number of 316 reported cases and 47 fatalities. The Greek WNV strains detected during 2010-2018 clustered within the central European subclade of lineage 2. Read More

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http://dx.doi.org/10.1007/s00705-019-04243-8DOI Listing
April 2019
4 Reads

A Polyphasic Approach for Assessing Eco-System Connectivity Demonstrates that Perturbation Remodels Network Architecture in Soil Microcosms.

Microb Ecol 2019 Apr 5. Epub 2019 Apr 5.

International Hellenic University, 14th km Thessaloniki-N. Moudania, 57001 Thermi, Thessaloniki, Greece.

Network analysis was used to show changes in network attributes by analyzing the relations among the main soil microbial groups in a potted tomato soil inoculated with arbuscular mycorrhizal fungus, treated with low doses of Mentha spicata essential oil, or both, and then exposed to tenfold higher oil addition (stress pulse). Pretreatments were chosen since they can induce changes in the composition of the microbial community. Cellular phospholipid fatty acids (PLFAs) and the activity of six soil enzymes, mainly involved in the N-cycle were measured. Read More

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http://dx.doi.org/10.1007/s00248-019-01367-xDOI Listing
April 2019
1 Read

Association of Notch and Hedgehog Pathway Activation With Prognosis in Early-stage Colorectal Cancer.

Anticancer Res 2019 Apr;39(4):2129-2138

Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece

Background/aim: Early-stage colorectal cancer (CRC) carries a wide range of survival probabilities. Novel biomarkers in this setting are eagerly awaited. Cancer stem cells (CSCs) are considered one of the reasons for treatment failure. Read More

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http://dx.doi.org/10.21873/anticanres.13326DOI Listing

Development and optimization of an underwater in-situ cerium bromide spectrometer for radioactivity measurements in the aquatic environment.

J Environ Radioact 2019 Apr 2;204:12-20. Epub 2019 Apr 2.

National Technical University of Athens, Department of Applied of Mathematic and Physical Sciences, Zografou Campus, Polythechnioupoli, GR-15780, Athens, Greece.

A new medium resolution gamma-ray spectrometer consisting of a cerium bromide (CeBr) crystal (2˝ x 2˝), is developed and optimized for radioactivity measurements in aquatic environments. This apparatus named GeoMAREA (Gamma-ray spectrometer for in-situ Marine Environmental Applications) is designed to control and prevent radio-contaminants in aquatic environments as well as to estimate the variation of natural radionuclides in marine systems for studying oceanographic processes. The system offers activity concentrations in Bq/m for detected gamma-ray emitters in the energy range from 150 to 2600 keV, and can provide sequential continuous monitoring data in a stand-alone mode or it can be integrated in stationary/mobile platforms for (near) real-time applications. Read More

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http://dx.doi.org/10.1016/j.jenvrad.2019.03.021DOI Listing
April 2019
3 Reads

Cardiovascular disease risk status during the years of the financial crisis: The Greek case.

Hellenic J Cardiol 2019 Apr 3. Epub 2019 Apr 3.

Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.

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http://dx.doi.org/10.1016/j.hjc.2019.03.005DOI Listing
April 2019
1 Read

Two-year clinical outcomes of medical therapy vs. revascularization for patients with coronary chronic total occlusion.

Hellenic J Cardiol 2019 Apr 2. Epub 2019 Apr 2.

Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian City, People's Republic of China. Electronic address:

Objectives: There are little data on the long-term clinical outcomes of medical therapy (MT) compared with revascularization in patients with chronic total occlusions (CTOs).

Methods: Between January 2007 and December 2016, a total of 1655 patients with ≥1 CTO were enrolled in our center and were divided into the MT group (n=800) and revascularization group (n=855) according to the initial treatment strategy. Propensity-score matching was also performed to adjust for baseline characteristics. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11099666183057
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http://dx.doi.org/10.1016/j.hjc.2019.03.006DOI Listing
April 2019
2 Reads

Smoker's Paradox In St Elevation Myocardial Infarction: Inflammation Beside Platelets.

Hellenic J Cardiol 2019 Apr 2. Epub 2019 Apr 2.

Coronary Care Unit and Laboratory of Clinical and Experimental Cardiology - Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Molecular Medicine, Unit of Cardiology, University of Pavia, Pavia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.hjc.2019.03.004DOI Listing
April 2019
2 Reads

Patterns in metabolite profile are associated with risk of more aggressive prostate cancer: a prospective study of 3057 matched case-control sets from EPIC.

Int J Cancer 2019 Apr 5. Epub 2019 Apr 5.

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.

Metabolomics may reveal novel insights into the aetiology of prostate cancer, for which few risk factors are established. We investigated the association between patterns in baseline plasma metabolite profile and subsequent prostate cancer risk, using data from 3057 matched case-control sets from the European Prospective Investigation into Cancer and Nutrition (EPIC). We measured 119 metabolite concentrations in plasma samples, collected on average 9. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32314
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http://dx.doi.org/10.1002/ijc.32314DOI Listing
April 2019
1 Read
5.085 Impact Factor

The putative polysaccharide deacetylase Ba0331: cloning, expression, crystallization and structure determination.

Acta Crystallogr F Struct Biol Commun 2019 Apr 3;75(Pt 4):312-320. Epub 2019 Apr 3.

Department of Biotechnology, Agricultural University of Athens, Iera Odos 75, 11855 Athens, Greece.

Ba0331 is a putative polysaccharide deacetylase from Bacillus anthracis, the etiological agent of the disease anthrax, that contributes to adaptation of the bacterium under extreme conditions and to maintenance of the cell shape. In the present study, the crystal structure of Ba0331 was determined at 2.6 Å resolution. Read More

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http://dx.doi.org/10.1107/S2053230X19001766DOI Listing
April 2019
1 Read

Predicting circulating CA125 levels among healthy premenopausal women.

Cancer Epidemiol Biomarkers Prev 2019 Apr 4. Epub 2019 Apr 4.

Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School.

Background: CA125 is the most promising ovarian cancer screening biomarker to date. Multiple studies reported CA125 levels vary by personal characteristics, which could inform personalized CA125 thresholds. However, this has not been well described in premenopausal women. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-1120DOI Listing
April 2019
3 Reads

Collaboration is the future of emergency medicine in Europe.

Eur J Anaesthesiol 2019 May;36(5):379-380

From the Department of Anaesthesiology and Perioperative Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larisa (AC), Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece (AC, TX), School of Medicine, European University Cyprus, Nicosia, Cyprus (TX) and Department of Anaesthesiology, Tzaneio General Hospital, Piraeus, Greece (FP).

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http://dx.doi.org/10.1097/EJA.0000000000000905DOI Listing
May 2019
1 Read

Sulfoaphane - role in aging and neurodegeneration.

Geroscience 2019 Apr 2. Epub 2019 Apr 2.

Departamento de Ciencias de la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, A.P. 55-535, 09340, Mexico City, Mexico.

In the last several years, numerous molecules derived from plants and vegetables have been tested for their antioxidant, anti-inflammatory, and anti-aging properties. One of them is sulforaphane (SFN), an isothiocyanate present in cruciferous vegetables. SFN activates the antioxidant and anti-inflammatory responses by inducing Nrf2 pathway and inhibiting NF-κB. Read More

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http://dx.doi.org/10.1007/s11357-019-00061-7DOI Listing
April 2019
2 Reads

Association of leukocyte DNA methylation changes with dietary folate and alcohol intake in the EPIC study.

Clin Epigenetics 2019 Apr 2;11(1):57. Epub 2019 Apr 2.

Nutritional Epidemiology Group, IARC, Lyon, France.

Background: There is increasing evidence that folate, an important component of one-carbon metabolism, modulates the epigenome. Alcohol, which can disrupt folate absorption, is also known to affect the epigenome. We investigated the association of dietary folate and alcohol intake on leukocyte DNA methylation levels in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Read More

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http://dx.doi.org/10.1186/s13148-019-0637-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444439PMC
April 2019
3 Reads

Wound ballistics of military rifle bullets: an update on controversial issues and associated misconceptions.

J Trauma Acute Care Surg 2019 Apr 1. Epub 2019 Apr 1.

SECRAB Security Research, SE-147 63 Uttran, Sweden.

The wound ballistics literature contains several misconceptions about the physical effects of penetrating projectiles in tissue and tissue simulants. These can adversely affect the proper management of gunshot injuries, particularly in view of the ongoing threat of terrorist and criminal acts using assault rifles against civilians. The understanding of the wounding effects by military rifle bullets can be founded on the concept of energy transfer to the wound as applied to high-energy missile trauma. Read More

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http://dx.doi.org/10.1097/TA.0000000000002290DOI Listing
April 2019
8 Reads

(Photo)electrocatalysis of molecular oxygen reduction by S-doped graphene decorated with a star-shaped oligothiophene.

Nanoscale 2019 Apr;11(15):7335-7346

Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece.

Heteroatom-doped graphene-based materials attract great interest as non-metal electrocatalysts for the oxygen reduction reaction (ORR). In this work, a straightforward approach was described to prepare nanoensembles of star-shaped oligothiophene 1 supramolecularly immobilized on sulfur-doped graphene sheets (SG). The 1/SG ensemble was comprehensively characterized by Raman and IR spectroscopy and morphologically imaged by HR-TEM, while the loading of 1 onto SG was estimated by TGA under an inert atmosphere. Read More

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http://dx.doi.org/10.1039/c9nr01620aDOI Listing
April 2019
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Insight into the role of chondroitin sulfate E in angiogenesis.

FEBS J 2019 Apr 1. Epub 2019 Apr 1.

Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, Greece.

Chondroitin sulfate E (CS-E) is a glycosaminoglycan containing type-E disaccharide units (sulfated at C-4 and C-6 of N-acetylgalactosamine). CS-E is covalently linked to a core protein to form chondroitin sulfate proteoglycans (PGs) that are secreted or associated with the plasma membrane of several types of cells. CS-E-containing PGs selectively interact with growth factors and chemokines and control various cellular and/or tissue processes. Read More

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http://dx.doi.org/10.1111/febs.14830DOI Listing

DNA damage accumulation, defective chromatin organization and deficient DNA repair capacity in patients with rheumatoid arthritis.

Clin Immunol 2019 Mar 28;203:28-36. Epub 2019 Mar 28.

First Department of Propaedeutic Internal Medicine and Joint Rheumatology Program, National and Kapodistrian University of Athens Medical School, Athens, Greece. Electronic address:

We investigated the DNA damage response and repair network in 18 patients with active rheumatoid arthritis and tested the hypothesis that treatment influences this network. A 3-fold increase of endogenous DNA damage (single- and double-strand breaks) was detected in patient-derived peripheral blood mononuclear cells than controls (alkaline comet assay; mean ± SD Olive Tail Moment of 11.8 ± 7. Read More

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http://dx.doi.org/10.1016/j.clim.2019.03.009DOI Listing
March 2019
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The prognostic value of CHADS-VASc and GRACE risk scores in acute coronary syndrome patients.

Authors:
George Hahalis

Hellenic J Cardiol 2019 Mar 28. Epub 2019 Mar 28.

University Hospital, Division of Cardiology, Rio, Patras, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.hjc.2019.03.003DOI Listing
March 2019
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Plant and sediment properties in seagrass meadows from two Mediterranean CO vents: Implications for carbon storage capacity of acidified oceans.

Mar Environ Res 2019 Mar 18. Epub 2019 Mar 18.

Department of Earth and Marine Sciences, University of Palermo, Via Archirafi 18, 90123, Palermo, Italy; National Inter-University Consortium for Marine Sciences, CoNISMa, Piazzale Flaminio 9, 00196, Roma, Italy.

Assessing the status of important carbon sinks such as seagrass meadows is of primary importance when dealing with potential climate change mitigation strategies. This study examined plant and sediment properties in seagrass meadows (Cymodocea nodosa (Ucria) Asch.) from two high pCO-low pH Mediterranean vent systems, located at Milos (Greece) and Vulcano (Italy) Islands, providing insights on carbon storage potential in future acidified oceans. Read More

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http://dx.doi.org/10.1016/j.marenvres.2019.03.001DOI Listing

HIV incidence among men who have sex with men at a community-based facility in Greece.

Cent Eur J Public Health 2019 Mar;27(1):54-57

Ath Checkpoint, Athens, Greece.

Objective: Men who have sex with men (MSM) are disproportionately affected by HIV in Greece. However, research on HIV incidence in this group is lacking. This study aimed at estimating HIV incidence among MSM in Athens, Greece. Read More

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http://dx.doi.org/10.21101/cejph.a4856DOI Listing
March 2019
1 Read