22,828 results match your criteria Helicobacter Pylori Infection


Helicobacter pylori infection and gastrointestinal tract cancer biology: considering a double-edged sword reflection.

Cell Mol Life Sci 2019 Apr 20. Epub 2019 Apr 20.

Department of Medicine, Second Medical Clinic, Ippokration Hospital, Aristotle University of Thessaloniki, 8 Fanariou St, Byzantio, 551 33, Thessaloniki, Macedonia, Greece.

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http://dx.doi.org/10.1007/s00018-019-03106-4DOI Listing

Rapidly decreasing prevalence of Helicobacter pylori among Japanese children and adolescents.

J Infect Chemother 2019 Apr 16. Epub 2019 Apr 16.

Department of Public Health, Aichi Medical University School of Medicine, Japan. Electronic address:

Background: The secular trend in the prevalence of Helicobacter pylori (H. pylori) infection among children and adolescents in Japan has not been well documented.

Materials And Methods: We reviewed all relevant literature published between 1991 and 2017, focusing on the relationship between the prevalence of H. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.02.016DOI Listing

Risks of substance uses, alcohol flush response, Helicobacter pylori infection and upper digestive tract diseases-An endoscopy cross-sectional study.

Kaohsiung J Med Sci 2019 Apr 18. Epub 2019 Apr 18.

Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

This study examines the effects of environmental hazards, including tobacco, alcohol/alcohol flush response, areca nut, and Helicobacter pylori (H pylori) infection on upper digestive diseases. This is a multi-hospital-based endoscopy-survey cross-sectional study. Subjects were received upper endoscopies in outpatient clinics at four hospitals in Taiwan between 2008 and 2013. Read More

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http://dx.doi.org/10.1002/kjm2.12071DOI Listing

Novel Insights of Lymphomagenesis of -Dependent Gastric Mucosa-Associated Lymphoid Tissue Lymphoma.

Cancers (Basel) 2019 Apr 17;11(4). Epub 2019 Apr 17.

Cancer Research Center, National Taiwan University College of Medicine, Taipei 100, Taiwan.

Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is the most common subtype of gastric lymphoma. Most gastric MALT lymphomas are characterized by their association with the (HP) infection and are cured by first-line HP eradication therapy (HPE). Several studies have been conducted to investigate why most gastric MALT lymphomas remain localized, are dependent on HP infection, and show HP-specific intratumoral T-cells (e. Read More

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http://dx.doi.org/10.3390/cancers11040547DOI Listing

Reconciliation of Recent Helicobacter pylori Treatment Guidelines in a Time of Increasing Resistance to Antibiotics.

Gastroenterology 2019 Apr 15. Epub 2019 Apr 15.

Department of Gastroenterology, Hepatology and infectious diseases, Otto-von-Guericke University, Magdeburg, Germany, and Ludwig Maximilian University Clinic, Med. Clinic II, Muenchen, Germany.

Increasing resistance to antibiotics, worldwide, has adverse effects on the effectiveness of standard therapies to eradicate Helicobacter pylori infection. We reviewed guidelines developed by expert groups in Europe, Canada, and the United States for the treatment of Helicobacter pylori infection. We compared the recommendations of these guidelines, reconciled them, and addressed the increasing resistance of H pylori to antibiotic therapy regimens. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193570
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http://dx.doi.org/10.1053/j.gastro.2019.04.011DOI Listing
April 2019
3 Reads

Bacterial glycosyltransferase-mediated cell-surface chemoenzymatic glycan modification.

Nat Commun 2019 Apr 17;10(1):1799. Epub 2019 Apr 17.

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA.

Chemoenzymatic modification of cell-surface glycan structures has emerged as a complementary approach to metabolic oligosaccharide engineering. Here, we identify Pasteurella multocida α2-3-sialyltransferase M144D mutant, Photobacterium damsela α2-6-sialyltransferase, and Helicobacter mustelae α1-2-fucosyltransferase, as efficient tools for live-cell glycan modification. Combining these enzymes with Helicobacter pylori α1-3-fucosyltransferase, we develop a host-cell-based assay to probe glycan-mediated influenza A virus (IAV) infection including wild-type and mutant strains of H1N1 and H3N2 subtypes. Read More

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http://www.nature.com/articles/s41467-019-09608-w
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http://dx.doi.org/10.1038/s41467-019-09608-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470217PMC
April 2019
1 Read
10.742 Impact Factor

Helicobacter pylori and hematological disorders.

Minerva Gastroenterol Dietol 2019 Apr 16. Epub 2019 Apr 16.

Hematology, AOU Città della Scienza e della Salute, Turin, Italy.

Helicobacter pylori (H. pylori) is one of the most common worldwide infection, which can affect adults as children. The prevalence of this bacterium is variable in different countries, depending on various hygienic and socioeconomic conditions and living customs. Read More

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https://www.minervamedica.it/index2.php?show=R08Y9999N00A190
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http://dx.doi.org/10.23736/S1121-421X.19.02580-7DOI Listing
April 2019
2 Reads

Astaxanthin Prevents Decreases in Superoxide Dismutase 2 Level and Superoxide Dismutase Activity in -infected Gastric Epithelial Cells.

J Cancer Prev 2019 Mar 30;24(1):54-58. Epub 2019 Mar 30.

Department of Food and Nutrition, Brian Korea 21 PLUS Project, College of Human Ecology, Yonsei University, Seoul, Korea.

Background: increases production of reactive oxygen species (ROS), which activates inflammatory and carcinogenesis-related signaling pathways in gastric epithelial cells. Therefore, reducing ROS, by upregulating antioxidant enzyme, such as superoxide dismutase (SOD), may be a novel strategy to prevent -associated gastric diseases. Astaxanthin is an antioxidant carotenoid that prevents oxidative stress-induced cell injury. Read More

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http://dx.doi.org/10.15430/JCP.2019.24.1.54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453584PMC

The Interaction of Infection and Type 2 Diabetes Mellitus.

Adv Biomed Res 2019 27;8:15. Epub 2019 Feb 27.

Department of Biochemistry, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

is one of the most common human pathogens that can cause gastrointestinal (GI) disorders, including simple gastritis, gastric ulcer, and malignant gastritis. In some cases, such as immunodeficiency and underlying diseases, it can be problematic as opportunistic infections. Diabetes mellitus (type 2) (T2DM) is one of the H. Read More

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http://dx.doi.org/10.4103/abr.abr_37_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425747PMC
February 2019
1 Read

The Association between Salt and Potential Mediators of the Gastric Precancerous Process.

Cancers (Basel) 2019 Apr 15;11(4). Epub 2019 Apr 15.

Department of Epidemiology, College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Background: The process by which salt affects the gastric precancerous process has not been adequately studied in humans.

Methods: We investigated the effects of salt on gastric inflammation, epithelial damage, the density of infection, and gastric epithelial cell proliferation, all of which may be mediators between salt and gastric precancerous/cancerous lesions. These potential mediators were measured using gastric biopsies as: (a) the density of polymorphonuclear and mononuclear cells (gastric inflammation), (b) mucus depletion (gastric epithelial damage), and (c) the severity of infection. Read More

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https://www.mdpi.com/2072-6694/11/4/535
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http://dx.doi.org/10.3390/cancers11040535DOI Listing
April 2019
1 Read

Gastric Cancer in Northern Canadian Populations: A Focus on Cardia and Non-Cardia Subsites.

Cancers (Basel) 2019 Apr 15;11(4). Epub 2019 Apr 15.

The CANHelp Working Group, University of Alberta, Edmonton, AB T6G 2E1, Canada.

In northern Canada where there is a high prevalence of infection, there is a paucity of information on gastric cancer by the topographical subsites cardia (CGC) and non-cardia (NCGC). Here we describe the incidence of CGC and NCGC, separately, among northern Canadian populations. We used data from the Cancer Incidence in Five Continents Volumes X (CI5X) and XI (CI5XI) to obtain CGC and NCGC incidence for Canada and for Yukon (YT), a northern Canadian territory. Read More

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http://dx.doi.org/10.3390/cancers11040534DOI Listing

Systematic review: Would susceptibility-guided treatment achieve acceptable cure rates for second-line Helicobacter pylori therapy as currently practiced?

Helicobacter 2019 Apr 16:e12584. Epub 2019 Apr 16.

Althaia University Assistance Network of Manresa, Barcelona, Spain.

Background: Susceptibility-guided treatment has been proposed as a way to improve Helicobacter pylori eradication rates. Evidence on its efficacy for rescue therapy is very scarce. The aim of this study was to indirectly assess the applicability and effectiveness of susceptibility-guided treatment by evaluating (a) the rate of acceptance of endoscopy, (b) its success in detecting resistances, and (c) infection cure rates in patients harboring strains found to be susceptible to the antibiotics administered in clinical trials in which the efficacy of second-line treatments was reported. Read More

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http://dx.doi.org/10.1111/hel.12584DOI Listing

Spasmolytic polypeptide-expressing metaplasia associated with higher expressions of miR-21, 155, and 223 can be regressed by Helicobacter pylori eradication in the gastric cancer familial relatives.

Helicobacter 2019 Apr 16:e12578. Epub 2019 Apr 16.

Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan.

Background And Aims: Spasmolytic polypeptide-expressing metaplasia (SPEM) is a preneoplastic gastric cancer lesion related to epigenetic microRNA (miRNA) expression. This study elucidated whether Helicobacter pylori-infected first-degree relatives of patients with gastric cancer (GCF) are susceptible to have SPEM and correlated with miR-21, 155, and 223 expressions. We also validated whether SPEM and these miRNAs can be regressed after H pylori eradication. Read More

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http://dx.doi.org/10.1111/hel.12578DOI Listing
April 2019
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Helicobacter pylori infection, atrophic gastritis, and risk of pancreatic cancer: A population-based cohort study in a large Japanese population: the JPHC Study.

Sci Rep 2019 Apr 15;9(1):6099. Epub 2019 Apr 15.

Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Helicobacter pylori (H. pylori), an established risk factor for gastric cancer, is suggested to also play a role in the development of pancreatic cancer; however, the association remains inconclusive. We examined this association among Japanese men and women. Read More

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http://dx.doi.org/10.1038/s41598-019-42365-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465350PMC
April 2019
1 Read

Eradication Treatment Alters Gut Microbiota and GLP-1 Secretion in Humans.

J Clin Med 2019 Apr 4;8(4). Epub 2019 Apr 4.

Department of Endocrinology and Nutrition, Virgen de la Victoria Hospital (IBIMA), Malaga University, 29010 Malaga, Spain.

Changes in the intestinal microbial community and some metabolic disturbances, including obesity and type2 diabetes, are related. Glucagon-like peptide-1 (GLP-1) regulates glucose homeostasis. Microbiota have been linked to incretin secretion. Read More

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http://dx.doi.org/10.3390/jcm8040451DOI Listing

Association between Dietary Salt Intake and Progression in the Gastric Precancerous Process.

Cancers (Basel) 2019 Apr 3;11(4). Epub 2019 Apr 3.

Department of Epidemiology, College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Gastric cancer is the third leading cause of cancer mortality worldwide. Studies investigating the effect of salt on gastric cancer have mainly used self-reported measures, which are not as accurate as sodium/creatinine ratios because individuals may not know the amount of salt in their food. Using data from a prospective cohort study, we investigated the effect of salt intake on progression to gastric precancerous lesions. Read More

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http://dx.doi.org/10.3390/cancers11040467DOI Listing
April 2019
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The regulatory role of C1q on Helicobacter pylori-induced inflammatory cytokines secretion in THP-1 cells.

Microb Pathog 2019 Apr 12;131:234-238. Epub 2019 Apr 12.

School of Basic Medical Sciences, Binzhou Medical University, Yantai, 264003, China. Electronic address:

C1q, as a LAIR-1 ligand, maintains monocytes quiescence and possess immunosuppressive properties. To understand the roles and molecular mechanisms, C1q mediated inflammation cytokines and several pivotal proteins in THP-1 cells after H. pylori infection were detected. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.017DOI Listing
April 2019
2 Reads

Prevalence and Risk Factors of Infection among Children Aged 1 to 15 Years at Holy Innocents Children's Hospital, Mbarara, South Western Uganda.

J Trop Med 2019 7;2019:9303072. Epub 2019 Mar 7.

Mbarara University of Science and Technology, Faculty of Medicine, Department of Medical Laboratory Sciences, P.O. Box 1410, Mbarara, Uganda.

Background: infection affects more than half of the world's population. The infection is generally acquired during childhood but can remain asymptomatic, with long-term clinical sequelae including gastritis, peptic ulcer disease, and stomach cancer.

Methods: The study was approved by Institutional Review Committee of Mbarara University of Science and Technology. Read More

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http://dx.doi.org/10.1155/2019/9303072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431523PMC
March 2019
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Neutralizing antibodies for Helicobacter pylori urease inhibit bacterial colonization in the murine stomach in vivo.

Biomed Res 2019 ;40(2):87-95

Department of Microbiology and Immunology, Nippon Medical School.

Helicobacter pylori (H. pylori) urease is a key protein for persistent infection of the bacteria in the stomach. Although H. Read More

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http://dx.doi.org/10.2220/biomedres.40.87DOI Listing
January 2019

Helicobacter pylori Vacuolating Cytotoxin A Causes Anorexia and Anxiety via Hypothalamic Urocortin 1 in Mice.

Sci Rep 2019 Apr 12;9(1):6011. Epub 2019 Apr 12.

Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Helicobacter pylori (Hp) infection is related to the pathogenesis of chronic gastric disorders and extragastric diseases. Here, we examined the anorexigenic and anxiogenic effects of Hp vacuolating cytotoxin A (VacA) through activation of hypothalamic urocortin1 (Ucn1). VacA was detected in the hypothalamus after peripheral administration and increased Ucn1 mRNA expression and c-Fos-positive cells in the hypothalamus but not in the nucleus tractus solitarius. Read More

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http://dx.doi.org/10.1038/s41598-019-42163-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461611PMC
April 2019
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Combination of Bismuth and Standard Triple Therapy Eradicates Helicobacter pylori Infection in More than 90% of Patients.

Clin Gastroenterol Hepatol 2019 Apr 9. Epub 2019 Apr 9.

- Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid (UAM), and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd). Madrid. SPAIN. Electronic address:

Background & Aims: Due to the poor eradication rates of standard triple therapy, the addition of bismuth salts has been proposed for first-line eradication of Helicobacter pylori. We assessed the effectiveness and safety of the combination of bismuth and the standard, clarithromycin-containing triple therapy in eradication of H pylori infection, using data from a large multi-center registry.

Methods: We performed an interim analysis of data from the European Registry on H pylori Management, a prospective trial registering clinical data and outcomes from infected patients from 27 countries in Europe since 2013. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.03.048DOI Listing
April 2019
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Biological evidence of the relationship between Helicobacter pylori and associated extragastric diseases.

J Cell Biochem 2019 Apr 11. Epub 2019 Apr 11.

Antimicrobial-Resistant Research Center, Iran University of Medical Sciences, Tehran, Iran.

Background: Gram-negative bacterium, Helicobacter pylori is notorious for various pathologies like peptic ulcers, gastritis, functional dyspepsia, and various cancers.

Methods: Systemic effects of its toxins have led scientists' attention toward the extragastric pathologies associated with it. To date, it has been shown to have an effect on almost all the systems in the human body. Read More

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http://dx.doi.org/10.1002/jcb.28681DOI Listing

Gastric Microbiota in -Negative and -Positive Gastritis Among High Incidence of Gastric Cancer Area.

Cancers (Basel) 2019 Apr 10;11(4). Epub 2019 Apr 10.

Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu-City, Oita 879-5593, Japan.

() related chronic gastritis is a well-known major etiological factor for gastric cancer development. However, -negative gastritis (HpN) is not well described. We aimed to examine gastric mucosal microbiota in HpN compared to -positive gastritis (HpP) and -negative non-gastritis group (control). Read More

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http://dx.doi.org/10.3390/cancers11040504DOI Listing
April 2019
1 Read

Infection in Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis.

Gut Liver 2019 Feb 27. Epub 2019 Feb 27.

Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea.

Background/aims: Insufficient systematic reviews were conducted in the previous metaanalyses about the prevalence of infection in patients with chronic kidney disease (CKD). The aim of this study was to evaluate the prevalence of infection in patients with CKD.

Methods: A systematic review of studies that evaluated the prevalence of infection in patients with CKD compared to a control group was performed. Read More

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http://dx.doi.org/10.5009/gnl18517DOI Listing
February 2019
1 Read

ABC Classification Is Less Useful for Older Koreans Born before 1960.

Gut Liver 2019 Feb 27. Epub 2019 Feb 27.

Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.

Background/aims: : In the ABC classification system, group A consists of seronegativesubjects without gastric corpus atrophy. This study aimed to determine the prevalence andcharacteristics of pseudo group A subjects.

Methods: : Group A subjects were identifiedamong consecutive Korean adults who underwent a serum anti-Helicobacter pyloriimmunoglobulin G (IgG) test and pepsinogen (PG) assay on the day of endoscopy. Read More

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http://dx.doi.org/10.5009/gnl18399DOI Listing
February 2019
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The Rationale and Efficacy of Primary and Secondary Prevention in Adenocarcinomas of the Upper Gastrointestinal Tract.

Dig Dis 2019 Apr 10:1-13. Epub 2019 Apr 10.

Department of Gastroenterology, Hepatology and Infectious Disease, Otto-von-Guericke University, Magdeburg, Germany.

While the primary risk factor for oesophageal adenocarcinoma (OAC) and its precursor lesion Barrett's oesophagus (BO) is gastro-oesophageal reflux, the infection with Helicobacter pylori (H. pylori) is the dominant risk factor for gastric cancer. Reduction of reflux by dietary measures and proton pump inhibitors has some merits in OAC prevention, and the chemopreventive effect of Aspirin and statins is being widely investigated; however, improved outcome in OAC occurs primarily as the result of secondary prevention. Read More

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http://dx.doi.org/10.1159/000499706DOI Listing
April 2019
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Efficacy of tailored therapy for Helicobacter pylori eradication based on clarithromycin resistance and survey of previous antibiotic exposure: A single-center prospective pilot study.

Helicobacter 2019 Apr 10:e12585. Epub 2019 Apr 10.

Department of Internal medicine, Kyungpook National University Hospital, Daegu, South Korea.

Background: As the prevalence of antibiotic resistance is increasing, the effectiveness of traditional Helicobacter pylori (H pylori) therapies is gradually declining. We aimed to evaluate the efficacy of tailored therapy (dual priming oligonucleotide [DPO]-based multiplex PCR) and previous antibiotic exposure survey predicting for antibiotic resistance.

Materials And Methods: Patients with H pylori infection who did not receive previous treatment were enrolled. Read More

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http://dx.doi.org/10.1111/hel.12585DOI Listing
April 2019
1 Read

Treatment of Gastrointestinal Symptoms and Mood Disorder With Physical Medicine and Supplementation: A Case Report.

Integr Med (Encinitas) 2018 Jun;17(3):53-58

all affiliated with the National University of Natural Medicine in Portland, Oregon.

This report details the naturopathic treatment of a 28-y-old female with a 1 y history of abdominal pain, heartburn, and constipation as well as longstanding anxiety and depression. Clinical evaluation ruled out organic causes of dyspepsia such as peptic ulcer disease, infection, and nonsteroidal anti-inflammatory drugs-induced dyspepsia. Treatment consisting of soft-tissue manipulation, homeopathic prescription, nutritional supplementation, and lifestyle modification greatly improved gastrointestinal and mental-emotional symptoms after 2 wk. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396765PMC
June 2018
1 Read

Association between infection with and platelet indices among school-aged children in central Ethiopia: a cross-sectional study.

BMJ Open 2019 Apr 8;9(4):e027748. Epub 2019 Apr 8.

Department of Biology, Colgate University Division of Natural Sciences and Mathematics, Hamilton, New York, USA.

Objective: Previous clinical studies in adults from developed countries have implicated infections in the development of thrombocytopenia. However, studies in children, particularly those from low-income countries, are unusually scarce. We examined the association between infection and platelet indices in young Ethiopian school children. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027748DOI Listing
April 2019
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A boy with duodenocolic fistula mimicking functional gastrointestinal disorder.

Clin J Gastroenterol 2019 Apr 6. Epub 2019 Apr 6.

Department of Pediatrics, Jichi Medical University, Shimotsuke, Tochigi, Japan.

Duodenocolic fistula (DCF) is a rare disorder defined by the presence of an internal fistula between the duodenum and colon. Colon cancer, Crohn's disease, diverticulum and duodenal ulcer are common causes of DCF, and vomiting and diarrhea are its main symptoms. We report a 14-year-old boy with DCF who had been treated for a functional gastrointestinal disorder (FGID). Read More

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http://dx.doi.org/10.1007/s12328-019-00977-9DOI Listing

Association between Helicobacter pylori infection and nonalcoholic fatty liver disease: a systemic review and meta-analysis.

Eur J Gastroenterol Hepatol 2019 Apr 3. Epub 2019 Apr 3.

Department of Gastroenterology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province.

Although clinical studies have shown possible links of Helicobacter pylori infection with the development of nonalcoholic fatty liver disease (NAFLD), the results remain controversial. The aim of this meta-analysis is to investigate the association between H. pylori infection and NAFLD. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001398DOI Listing
April 2019
3 Reads

Helicobacter pylori infection and nonalcoholic fatty liver disease: Time for large clinical trials evaluating eradication therapy.

Helicobacter 2019 Apr 5:e12588. Epub 2019 Apr 5.

Second Medical Clinic, Faculty of Medicine, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Greece.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/hel.12588
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http://dx.doi.org/10.1111/hel.12588DOI Listing
April 2019
3 Reads

Impact factors that modulate gastric cancer risk in Helicobacter pylori-infected rodent models.

Helicobacter 2019 Apr 4:e12580. Epub 2019 Apr 4.

Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Gastric cancer causes a large social and economic burden to humans. Helicobacter pylori (H pylori) infection is a major risk factor for distal gastric cancer. Detailed elucidation of H pylori pathogenesis is significant for the prevention and treatment of gastric cancer. Read More

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http://dx.doi.org/10.1111/hel.12580DOI Listing

Management of Helicobacter pylori infection at the primary care level. The implementation of specific counseling improves eradication rates.

Helicobacter 2019 Apr 5:e12586. Epub 2019 Apr 5.

Service of digestive diseases, Hospital ClínicoUniversitario Lozano Blesa, Zaragoza, Spain.

Background: Management of Helicobacter pylori infection has been expanded from the gastroenterology specialist (GS) to primary care physicians (PCPs), with a large increase in requests for urea breath tests (UBT). Due to the lack of evidence at this level, we evaluated the appropriateness of UBT indications and treatment for H pylori infections between PCPs and GSs and the effect of introducing specific counseling to PCPs.

Materials And Methods: This was a quasi-experimental study. Read More

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http://dx.doi.org/10.1111/hel.12586DOI Listing
April 2019
2 Reads

Helicobacter pylori resistance to clarithromycin and fluoroquinolones in a pediatric population in Turkey: A cross-sectional study.

Helicobacter 2019 Apr 4:e12581. Epub 2019 Apr 4.

Infectious Diseases & Clinical Microbiology Department, Kırıkkale University Medical School, Kırıkkale, Turkey.

Background: Helicobacter pylori antimicrobial resistance is gradually increasing around the world. However, there are a limited number of studies reporting on this issue in the pediatric population. In this study, we aimed to determine H pylori resistance to clarithromycin and fluoroquinolones in the pediatric patients living in Kırıkkale province that were detected with H pylori in gastric biopsies. Read More

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http://dx.doi.org/10.1111/hel.12581DOI Listing

Changes of tight junction and interleukin-8 expression using a human gastroid monolayer model of Helicobacter pylori infection.

Helicobacter 2019 Apr 5:e12583. Epub 2019 Apr 5.

Department of Gastroenterology and Hepatology, Baylor College of Medicine and Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas.

Background: Lack of a model that mirrors Helicobacter pylori-induced gastric mucosal inflammation has hampered investigation of early host-bacterial interactions. We used an ex vivo model of human stomach, gastric epithelial organoid monolayers (gastroid monolayers) to investigate interactions of H pylori infection and the apical junctional complex and interleukin-8 (IL-8) expression.

Method: Morphology of human antral mucosal gastroid monolayers was evaluated using histology, immunohistochemical (IHC) staining, and transmission electron microscopy (TEM). Read More

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http://dx.doi.org/10.1111/hel.12583DOI Listing

-induced matrix metallopeptidase-10 promotes gastric bacterial colonization and gastritis.

Sci Adv 2019 Apr 3;5(4):eaau6547. Epub 2019 Apr 3.

National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, China.

The interaction between gastric epithelium and immune response plays key roles in -associated pathology. We demonstrated a procolonization and proinflammation role of MMP-10 in infection. MMP-10 is elevated in gastric mucosa and is produced by gastric epithelial cells synergistically induced by and IL-22 via the ERK pathway. Read More

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http://advances.sciencemag.org/lookup/doi/10.1126/sciadv.aau
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http://dx.doi.org/10.1126/sciadv.aau6547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447374PMC
April 2019
4 Reads

Prevalence of infection in Sari Northern Iran; a population based study.

Gastroenterol Hepatol Bed Bench 2019 ;12(1):31-37

Associate professor, Department of Biostatistics, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran.

Aim: In this study prevalence rate of and its associated factors have been investigated in urban and rural areas of Sari.

Background: has an important role in gastrointestinal diseases including peptic ulcer and gastric cancer. It is the most common infection in human population worldwide. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441486PMC
January 2019
2 Reads

Epidemiology of gastric cancer: global trends, risk factors and prevention.

Prz Gastroenterol 2019 28;14(1):26-38. Epub 2018 Nov 28.

Hillman Cancer Center, University of Pittsburgh, PA, USA.

Gastric cancer remains one of the most common and deadly cancers worldwide, especially among older males. Based on GLOBOCAN 2018 data, stomach cancer is the 5 most common neoplasm and the 3 most deadly cancer, with an estimated 783,000 deaths in 2018. Gastric cancer incidence and mortality are highly variable by region and highly dependent on diet and infection. Read More

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http://dx.doi.org/10.5114/pg.2018.80001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444111PMC
November 2018

Prevalence of and Its Associated Factors among Healthy Asymptomatic Residents in the United Arab Emirates.

Pathogens 2019 Apr 1;8(2). Epub 2019 Apr 1.

Laboratoire de bactériologie, Hygiène, EA 4331 LITEC, CHU de Poitiers, Université de Poitiers, Poitiers 86000, France.

The United Arab Emirates (UAE) has been under continuous populational influences from Asia, Europe, and Africa, making it an ideal site for epidemiological studies on . However, there has been a paucity of well-designed prevalence studies on from UAE. The aim of this study was to determine the prevalence of and its associated risk factors in the UAE. Read More

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http://dx.doi.org/10.3390/pathogens8020044DOI Listing

Risk and predictors of esophageal and stomach cancers in HIV-infected veterans: A matched cohort study.

J Acquir Immune Defic Syndr 2019 Mar 29. Epub 2019 Mar 29.

Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX.

Background: Evaluate the risks of esophageal and stomach carcinomas in people living with HIV (PLWH) compared with the general population as well as risk factors for these cancers in PLWH.

Setting: Retrospective cohort study in the Veterans Health Administration.

Methods: We compared incidence rates for esophageal and stomach cancers in 44,075 HIV-infected male veterans with those in a matched HIV-uninfected cohort (N=157,705; 4:1 matched on age and HIV-index date). Read More

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http://dx.doi.org/10.1097/QAI.0000000000002038DOI Listing
March 2019
8 Reads

Effect of Helicobacter pylori Treatment on Unexplained Iron Deficiency Anemia.

Perm J 2019 ;23

Department of Adult and Family Medicine, Santa Clara Medical Center, CA.

Background: A large number of patients with iron deficiency anemia have no known cause of their anemia despite a full evaluation. Optimal management and follow-up for this issue is unclear. Results of previous studies have implicated Helicobacter pylori infection as a potential cause of iron deficiency anemia. Read More

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http://dx.doi.org/10.7812/TPP/18-195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443360PMC
January 2019
2 Reads

Are Patients with Perforated Peptic Ulcers Who are Negative for Helicobacter pylori at a Greater Risk?

Surg Infect (Larchmt) 2019 Apr 2. Epub 2019 Apr 2.

1 Department of Surgery, Washington University in Saint Louis, Saint Louis, Missouri.

Background: The link between Helicobacter pylori infection and peptic ulceration is well established. Recent studies have reported a decrease of H. pylori-related peptic ulcer disease; Helicobacter pylori eradication is likely the cause of this decrease. Read More

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http://dx.doi.org/10.1089/sur.2018.249DOI Listing
April 2019
6 Reads

Common variable immunodeficiency syndrome with chronic diarrhoea.

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

Department of Gastroenterology, Medanta-The Medicity, Gurgaon, India.

Common variable immunodeficiency syndrome (CVID) is a heterogeneous disorder characterised by diminished levels of IgG, IgA and/or IgM, and recurrent bacterial infections. Sinopulmonary infections are most commonly reported followed by gastrointestinal (GI) infections. GI tract represents the largest immune organ with abundance of lymphoid cells, its involvement can manifest variably ranging from asymptomatic involvement to florid symptoms and signs. Read More

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http://dx.doi.org/10.1136/bcr-2018-228240DOI Listing
March 2019
1 Read

In Vitro and Activities of Zinc Linolenate, a Selective Antibacterial Agent against .

Antimicrob Agents Chemother 2019 Apr 1. Epub 2019 Apr 1.

Department of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu 211166, China

is a major global pathogen and its infection represents a key factor in the etiology of various gastric diseases including gastritis, peptic ulcers and gastric carcinoma. The efficacy of current standard treatment for infection including two broad-spectrum antibiotics is compromised by toxicity toward gut microbiota and development of drug resistance, which will likely only be resolved through novel and selective antibacterial strategies. Here, we synthesized a small molecule, Zinc linolenate (ZnLla), and investigated its therapeutic potential for the treatment of infection. Read More

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http://aac.asm.org/lookup/doi/10.1128/AAC.00004-19
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http://dx.doi.org/10.1128/AAC.00004-19DOI Listing
April 2019
4 Reads

The effect of synbiotics in improving Helicobacter pylori eradication: A systematic review and meta-analysis.

Complement Ther Med 2019 Apr 9;43:36-43. Epub 2019 Jan 9.

Gastrointestinal & Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences (GUMS), Rasht, Iran; Caspian Digestive Diseases Research Center, Guilan University of Medical Sciences (GUMS), Rasht, Iran. Electronic address:

Background: Helicobacter pylori is a common human infection, presenting in half of the world's population. The failure of the Helicobacter pylori eradication rate necessitates the assessment of new options. The aim of the present meta-analysis was therefore to assess the role of synbiotics in Helicobacter pylori eradication therapy. Read More

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http://dx.doi.org/10.1016/j.ctim.2019.01.005DOI Listing
April 2019
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Time trends in the incidence of esophageal adenocarcinoma, gastric adenocarcinoma, and superficial esophagogastric junction adenocarcinoma.

J Gastroenterol 2019 Mar 29. Epub 2019 Mar 29.

Cancer Control Center, Osaka International Cancer Institute, Osaka, Japan.

Background: In Japan, the incidence of esophageal adenocarcinoma (EAC) and esophagogastric junction (EGJ) adenocarcinoma is expected to increase and that of gastric adenocarcinoma (GAC) is expected to decrease due to Westernization of the diet and the decreasing prevalence of Helicobacter pylori infection. However, few reports about these trends have included the latest data, and no reports about the time trend in the incidence of EGJ adenocarcinoma have focused on the etiologies (gastric cardia adenocarcinoma or EAC, including Barrett's adenocarcinoma). We therefore investigated the time trends in the incidence of these cancers by including the latest data. Read More

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http://dx.doi.org/10.1007/s00535-019-01577-7DOI Listing
March 2019
2 Reads

Development and validation of a prediction rule for estimating gastric cancer risk in the Chinese high-risk population: a nationwide multicentre study.

Gut 2019 Mar 29. Epub 2019 Mar 29.

Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China.

Objective: To develop a gastric cancer (GC) risk prediction rule as an initial prescreening tool to identify individuals with a high risk prior to gastroscopy.

Design: This was a nationwide multicentre cross-sectional study. Individuals aged 40-80 years who went to hospitals for a GC screening gastroscopy were recruited. Read More

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2018-317556
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http://dx.doi.org/10.1136/gutjnl-2018-317556DOI Listing
March 2019
8 Reads

Clinicopathological features of duodenal bulb biopsies and their relationship with upper gastrointestinal diseases.

Ann Diagn Pathol 2019 Feb 10;40:40-44. Epub 2019 Feb 10.

Department of Gastroenterology, Peking University Third Hospital, 49 Rd. Garden, Haidian District, Beijing, PR China.

Aim: To assess the prevalence of the lesions in duodenal bulb mucosa and the relationship between duodenal lesions and upper gastrointestinal diseases, including helicobacter pylori infection.

Methods: Clinical, endoscopic and pathological data of the cases with duodenal bulb and gastric mucosal biopsy from January 2005 to May 2017 were analyzed retrospectively.

Results: A total of 3540 patients were enrolled. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.006DOI Listing
February 2019
2 Reads

Prevalence of Autoimmune Gastritis in Individuals Undergoing Medical Checkups in Japan.

Intern Med 2019 Mar 28. Epub 2019 Mar 28.

Second Department of Internal Medicine, Shimane University Faculty of Medicine, Japan.

Objective Based on both endoscopic findings and serum auto-antibody levels, we determined the prevalence of Autoimmune gastritis (AIG), which has not been previously reported, in individuals who underwent health checkup examinations in Japan. Methods At total of 6,739 subjects (4,288 males, 2,451 females; mean age 52.1 years) underwent an upper GI endoscopic examination as part of an annual medical checkup. Read More

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http://dx.doi.org/10.2169/internalmedicine.2292-18DOI Listing
March 2019
1 Read