38,526 results match your criteria Helicobacter Pylori Infection

A Culture-Based Strategy Is More Cost Effective Than an Empiric Therapy Strategy in Managing Pediatric Infection.

Front Pediatr 2022 3;10:860960. Epub 2022 May 3.

Department of Pediatrics and Institute of Clinical Medicine, National Cheng Kung University Hospital, Medical College, National Cheng Kung University, Tainan, Taiwan.

Background: infection is a major cause of peptic ulcers and gastric cancer. This study aimed to compare the eradication rate and essential costs of culture-based and empiric therapy strategies in treating pediatric infection.

Methods: We retrospectively enrolled patients aged <18 years with a diagnosis of infection who received esophagogastroduodenoscopy at two medical centers in southern Taiwan from 1998 to 2018. Read More

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Is the Presence of Helicobacter Pylori in the Colonic Mucosa, Provocative of Activity in Ulcerative Colitis?

Clin Pathol 2022 Jan-Dec;15:2632010X221096660. Epub 2022 May 12.

Department of Microbiology, College of Science, Agriculture and Modern Technology, Shiraz Branch, Islamic Azad University, Shiraz, Iran.

Background: Epidemiologic studies have shown world-wide increasing incidence of ulcerative colitis (UC) as an autoimmune disease of intestine. In the meantime, gastrointestinal H. Pylori infection is being decreased. Read More

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Prevalence of in Non-Cardia Gastric Cancer in China: A Systematic Review and Meta-Analysis.

Front Oncol 2022 3;12:850389. Epub 2022 May 3.

School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, China.

Non-cardia gastric cancer was significantly associated with () infection. Reducing prevalence was an important prevention strategy for non-cardia gastric cancer. However, national-level data on the prevalence in non-cardia gastric cancer were limited in China. Read More

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Quantification of the Landscape for Revealing the Underlying Mechanism of Intestinal-Type Gastric Cancer.

Chong Yu Jin Wang

Front Oncol 2022 3;12:853768. Epub 2022 May 3.

Department of Chemistry and of Physics and Astronomy, State University of New York at Stony Brook, Stony Brook, NY, United States.

Gastric cancer is a daunting disease with a tragic impact on global health. It is the fourth most common cancer and has become the second most frequent cause of cancer death in recent times. According to the Lauren classification, gastric cancer can be classified into two types: intestinal and diffuse. Read More

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Potential association between bacterial infections and ischemic stroke based on fifty case-control studies: A systematic review and meta-analysis.

New Microbes New Infect 2022 Apr-May;47:100980. Epub 2022 Apr 15.

Department of Microbiology and Virology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran.

Background: Stroke is considered as one of the most important concerns in health care centers around the world. By definition there are two types of stroke including ischemic stroke and hemorrhagic stroke. Approximately three-quarters of stroke cases are ischemic strokes, which occur due to several risk factors such as hypertension, obesity, atherosclerosis, diabetes mellitus, osteoarthritis, and inflammatory responses. Read More

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Induction of FGFR4 by H. pylori via STAT3 with a feedforward activation loop involving SRC signaling in gastric cancer.

Gastroenterology 2022 May 16. Epub 2022 May 16.

Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, 33136, USA; Department of Veterans Affairs, Miami Healthcare System, Miami, Florida, USA. Electronic address:

Background & Aims: Helicobacter pylori (H. pylori) infection is the main risk factor for gastric cancer. The role of Fibroblast Growth Factor Receptors in H. Read More

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1α, 25-Dihydroxyvitamin D3 protects gastric mucosa epithelial cells against -infected apoptosis through a vitamin D receptor-dependent c-Raf/MEK/ERK pathway.

Pharm Biol 2022 Dec;60(1):801-809

Department of Gastroenterology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Context: Due to the resistance of to antibiotics, it is difficult to eradicate this pathogenic bacterium from the host. The role of 1α, 25-dihydroxyvitamin D3 (1,25-D3) in -infected gastric mucosa epithelial cells remains unknown.

Objective: This study investigates the protective property of 1,25-D3 against -infected apoptosis in gastric mucosa epithelial cells and its potential molecular mechanisms. Read More

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December 2022

Nitazoxanide-based therapeutic regimen as a novel treatment for Helicobacter pylori infection in children and adolescents: a randomized trial.

Eur Rev Med Pharmacol Sci 2022 May;26(9):3132-3137

Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Egypt.

Objective: Antibiotic resistance and poor patient compliance with treatment cause Helicobacter pylori to show increased resistance to typical first-line therapeutic regimens. This study aimed to evaluate the efficacy of the new nitazoxanide-based treatment regimens for Helicobacter pylori infection vs. the current metronidazole-based regimens to address the problem of increasing metronidazole resistance. Read More

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Differential expression of metallothionein and p21 in gastric cancer and some precursor lesions.

Eur Rev Med Pharmacol Sci 2022 May;26(9):3100-3108

Department of Pathology, Department of Hepatology and Gastroenterology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt.

Objective: Gastric cancer (GC) is a heterogeneous disease with molecular diversity between and within tumors; therefore, searching for altered genes within this cancer is mandatory to reach the proper individualized targeted therapy. Expressions of Metallothionein (MT) and p21 are not uniform in various types of cancers and their predictive value in GC is controversial. This study aimed to assess the role of MT and p21 in intestinal-type GC and some of its precursor lesions. Read More

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Rapid and Sensitive Assay of With One-Tube RPA-CRISPR/Cas12 by Portable Array Detector for Visible Analysis of Thermostatic Nucleic Acid Amplification.

Front Microbiol 2022 2;13:858247. Epub 2022 May 2.

Department of Biopharmaceutics, State Key Laboratory of Cancer Biology, Air Force Medical University, Xi'an, China.

() has infected more than half of the world's population and is still a threat to human health. The urea breath test, despite being widely used in clinical diagnosis, still faces huge challenges in the immediate detection of . Thus, a rapid, sensitive, and highly specific point of care diagnosis is particularly important for preventing the further transmission of and for real-time monitoring of the disease in a given population. Read More

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Role of magnifying narrow-band imaging endoscopy for diagnosis of infection and gastric precancerous conditions: Few issues.

World J Gastroenterol 2022 Apr;28(15):1601-1603

Department of Gastroenterology, IMS and SUM Hospital, SOA University, Bhubaneswar 751003, Odisha, India.

Standard endoscopy with biopsy and narrow-band imaging with guided biopsy are techniques for the detection of -related gastritis and precancerous lesions. In this study, the authors compared standard endoscopy and magnified narrow-band imaging (commonly known as NBI-M) in the diagnosis of infections, atrophic gastritis, and intestinal metaplasia. Although the sensitivity of NBI-M is better than standard endoscopy, the diagnostic accuracy did not differ substantially between the diagnostic modalities. Read More

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CTH exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation.

JCI Insight 2022 May 17. Epub 2022 May 17.

Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America.

Macrophages play a crucial role in the inflammatory response to the human stomach pathogen Helicobacter pylori, which infects half of the world's population and causes gastric cancer. Recent studies have highlighted the importance of macrophage immunometabolism in their activation state and function. We have demonstrated that the cysteine-producing enzyme, cystathionine g-lyase (CTH), is upregulated in humans and mice with H. Read More

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Gastrointestinal neoplasia: carcinogenic interaction between bile acids and Helicobacter pylori in the stomach.

J Clin Invest 2022 May;132(10)

Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Bile acids modulate cell functions in health and disease, however, the mechanisms underlying their actions on neoplastic cells in the gastrointestinal (GI) tract remain largely unknown. In this issue of the JCI, Noto et al. comprehensively analyzed how interactions between Helicobacter pylori infection, iron deficiency, and bile acids modulate gastric inflammation and carcinogenesis. Read More

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Helicobacter Pylori Colonization Density is an Important Risk Factor for Eradication Therapy.

J Gastrointestin Liver Dis 2022 May 14. Epub 2022 May 14.

Department of Gastroenterology, Healty Sciences University, Gulhane Training and Research Hospital, Ankara.

Background And Aims: Despite the known risk factors, it is not clear why the same treatment protocol for Helicobacter pylori infection (H. pylori) doesnot show a similar effect in patients with common risk factors. We hypothesized that as the severity of H. Read More

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An Updated Meta-Analysis of the Relationship Between Infection and the Risk of Coronary Heart Disease.

Front Cardiovasc Med 2022 29;9:794445. Epub 2022 Apr 29.

Department of Cardiology, Shanxi Cardiovascular Hospital, Taiyuan, China.

Background: Coronary heart disease (CHD) is one of the leading causes of mortality in the world. Although the traditional risk factors for CHD have been identified, it seems that there are still many CHD cases without these factors. Previous studies have hypothesized that () infection was associated with the risk of CHD. Read More

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Comparison of the Dual Therapy of Ilaprazole-Amoxicillin and the Bismuth Quadruple Therapy of Ilaprazole-Amoxicillin-Furazolidone-Bismuth Glycyrrhizinate for Eradication of .

Front Pharmacol 2022 27;13:771876. Epub 2022 Apr 27.

Department of Gastroenterology, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, China.

The present study aims to compare the safety and efficacy of an amoxicillin/ilaprazole regimen with a bismuth quadruple regimen as the first-line treatment for eradicating () infection. This was an open-label, randomized, single-center study involving 450 patients with untreated infection who were randomly assigned to an Ilaprazole-amoxicillin-furazolidone-bismuth glycyrrhizinate (IAFB) quadruple therapy group for 14 days, a bismuth quadruple therapy group for 10 days, or Ilaprazole-amoxicillin (IA) dual therapy group for 14 days. The 13C urea breath test determined that had been eliminated 4-6 weeks after treatment. Read More

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Beyond the gastric epithelium - the paradox of Helicobacter pylori-induced immune responses.

Curr Opin Immunol 2022 May 12;76:102208. Epub 2022 May 12.

Department of Biosciences and Medical Biology, University of Salzburg, Austria; Cancer Cluster Salzburg (CCS), Austria. Electronic address:

Chronic infections are typically characterized by an ineffective immune response to the inducing pathogen. While failing to clear the infectious microbe, the provoked inflammatory processes may cause severe tissue damage culminating in functional impairment of the affected organ. The human pathogen Helicobacter pylori is a uniquely successful Gram-negative microorganism inhabiting the gastric mucosa in approximately 50% of the world's population. Read More

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MNPmApp: An image analysis tool to quantify mononuclear phagocyte distribution in mucosal tissues.

Cytometry A 2022 May 15. Epub 2022 May 15.

Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT.

Mononuclear phagocytes (MNPs) such as dendritic cells and macrophages perform key sentinel functions in mucosal tissues and are responsible for inducing and maintaining adaptive immune responses to mucosal pathogens. Positioning of MNPs at the epithelial interface facilitates their access to luminally-derived antigens and regulates MNP function through soluble mediators or surface receptor interactions. Therefore, accurately quantifying the distribution of MNPs within mucosal tissues as well as their spatial relationship with other cells is important to infer functional cellular interactions in health and disease. Read More

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Engineering a novel immunogenic chimera protein utilizing bacterial infections associated with atherosclerosis to induce a deviation in adaptive immune responses via Immunoinformatics approaches.

Infect Genet Evol 2022 May 11:105290. Epub 2022 May 11.

USERN Office, Babol University of Medical Sciences, Babol, Iran; Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Immunoregulation Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Electronic address:

Recent studies have established the role of bacteria including Streptococcus pneumoniae, Helicobacter pylori, Chlamydia pneumonia, Mycobacterium tuberculosis, and Porphyromonas gingivalis in the development of atherosclerosis. These bacteria contribute to plaque formation via promoting Th1 immune responses and speeding up ox-LDL formation. Hence, we employed computational reverse vaccinology (RV) approaches to deviate immune response toward Th2 via engineering a novel immunogenic chimera protein. Read More

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Antibodies towards TVLLPVIFF Amino Acid Sequence of TNF Receptor Induced by in Patients with Coronary Heart Disease.

J Clin Med 2022 May 1;11(9). Epub 2022 May 1.

Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Łódź, Banacha 12-16, 90-237 Lodz, Poland.

Background: Molecular mimicry between (Hp) and the host components resulting in induction of cross-reacting antibodies has been suggested as accessory mechanism in the development of coronary heart disease (CHD). A potential target for antibodies induced during Hp infection by the components of these bacteria might be amino acid sequence TVLLPVIFF (P1) of tumor necrosis factor receptor (TNFR), which is exposed on vascular endothelium and immunocompetent cells, driving inflammation.

Aim: To examine whether anti-P1 IgG are induced during Hp infection in CHD patients. Read More

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Infection in a Pediatric Population from Romania: Risk Factors, Clinical and Endoscopic Features and Treatment Compliance.

J Clin Med 2022 Apr 26;11(9). Epub 2022 Apr 26.

Faculty of Medicine, "Titu Maiorescu" University of Medicine, 67A Gheorghe Petrascu Str., 031593 Bucharest, Romania.

Background And Objectives: The aim of this study was to investigate the association between positivity with specific symptoms, risk factors and endoscopic patterns among the pediatric population in northeastern Romania.

Materials And Methods: A prospective study was performed in 18 months on 185 children aged 6-18 years with an indication for upper digestive endoscopy. Demographic, anamnestic, symptomatic, endoscopic and histologic data were recorded. Read More

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Increased Risk to Develop Hypertension and Carotid Plaques in Patients with Long-Lasting Gastritis.

J Clin Med 2022 Apr 19;11(9). Epub 2022 Apr 19.

Dipartimento di Scienze Mediche, Chirurgiche e Sperimentali, University of Sassari, Viale San Pietro 8, 07100 Sassari, Italy.

infection has been reported to be positively associated with hypertension, although with conflicting results. In this study, the relationship between infection and hypertension, as well as atherosclerotic carotid lesions, was analyzed.

Methods: Clinical records of patients referred to undergo upper endoscopy and gastric biopsy were retrieved. Read More

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Gastric Cancer Pre-Stage Detection and Early Diagnosis of Gastritis Using Serum Protein Signatures.

Molecules 2022 Apr 30;27(9). Epub 2022 Apr 30.

IZKF Core Unit Proteomics, University of Münster, 48149 Münster, Germany.

Background: A gastric cancer (GC) diagnosis relies on histopathology. Endoscopy rates are increasing. infection is a major GC risk factor. Read More

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The Nutraceutical Properties of Sumac ( L.) against Gastritis: Antibacterial and Anti-Inflammatory Activities in Gastric Epithelial Cells Infected with .

Nutrients 2022 Apr 22;14(9). Epub 2022 Apr 22.

Department of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, Italy.

Sumac ( L.) is a spice and medicinal herb traditionally used in the Mediterranean region and the Middle East. Since we previously demonstrated Sumac biological activity in a model of tumor necrosis factor alpha (TNF-α)-induced skin inflammation, the present work is aimed at further demonstrating a potential role in inflammatory disorders, focusing on gastritis. Read More

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Upper Gastrointestinal Cancer and Liver Cirrhosis.

Cancers (Basel) 2022 May 2;14(9). Epub 2022 May 2.

Division of General Surgery, Far Eastern Memorial Hospital, New Taipei City 22060, Taiwan.

The extended scope of upper gastrointestinal cancer can include esophageal cancer, gastric cancer and pancreatic cancer. A higher incidence rate of gastric cancer and esophageal cancer in patients with liver cirrhosis has been reported. It is attributable to four possible causes which exist in cirrhotic patients, including a higher prevalence of gastric ulcers and congestive gastropathy, zinc deficiency, alcohol drinking and tobacco use and coexisting gut microbiota. Read More

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Antibacterial Effects of Bacteriocin PLNC8 against and Its Potential Mechanism of Action.

Foods 2022 Apr 25;11(9). Epub 2022 Apr 25.

College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China.

() is a bacterium that can cause a variety of gastric diseases. Most bacteriocins have gained popularity due to their non-toxic effects on cells and antibacterial effects against a wide range of pathogenic bacteria. In this study, the chemical synthesis of the bipeptide bacteriocin PLNC8 was used to investigate its possible action mechanism against ZJC03 in vitro. Read More

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Helicobacter pylori Infection Mediates Inflammation and Tumorigenesis-Associated Genes Through miR-155-5p: An Integrative Omics and Bioinformatics-Based Investigation.

Curr Microbiol 2022 May 13;79(7):192. Epub 2022 May 13.

Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Helicobacter pylori (H. pylori) is a major human pathogenic bacterium that survives in the gastric mucosa. The aim of this study is to evaluate the expression of the target gene network of miR-155-5p in H. Read More

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Susceptibility of Genetic Variations in Methylation Pathway to Gastric Cancer.

Pharmgenomics Pers Med 2022 4;15:441-448. Epub 2022 May 4.

Clinical Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, People's Republic of China.

Background: DNA methylation in the CpG island is associated with gastric cancer, genetic variations residue in genes involved in methylation pathway could contribute to the occurrence of gastric cancer. Here, we investigated the association between (), genetic variations and gastric cancer risk and patients' survival.

Patients And Methods: We recruited 490 gastric cancer patients and 488 age- and sex-matched healthy controls. Read More

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The Effects of Infection on Gastric Microbiota in Children With Duodenal Ulcer.

Front Microbiol 2022 25;13:853184. Epub 2022 Apr 25.

Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, China.

Background: () infection is the main cause of chronic gastritis and duodenal ulcer in children. Little is known about the effect of on gastric microbiota in children with duodenal ulcer. This study is aimed at the characteristics of gastric microbiota in children with duodenal ulcer on infection. Read More

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Peptic Ulcer and Gastric Cancer: Is It All in the Complex Host-Microbiome Interplay That Is Encoded in the Genomes of "Us" and "Them"?

Front Microbiol 2022 25;13:835313. Epub 2022 Apr 25.

Rajiv Gandhi Centre for Biotechnology, Trivandrum, India.

It is increasingly being recognized that severe gastroduodenal diseases such as peptic ulcer and gastric cancer are not just the outcomes of infection in the stomach. Rather, both diseases develop and progress due to the perfect storms created by a combination of multiple factors such as the expression of different virulence proteins, consequent human immune responses, and dysbiosis in gastrointestinal microbiomes. In this mini review, we have discussed how the genomes of and other gastrointestinal microbes as well as the genomes of different human populations encode complex and variable virulome-immunome interplay, which influences gastroduodenal health. Read More

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