36,940 results match your criteria Helicobacter Pylori Infection

Rates and Risk Factors for Interval Gastric Cancers at Screening Gastroscopy.

Turk J Gastroenterol 2021 Feb;32(2):194-202

Department of Internal Medicine, Hanyang University School of Medicine, Seoul, South Korea.

Backgrounds/aims: Interval gastric cancers (GCs) can be encountered during screening gastroscopy. This study investigated the rate of interval GCs and their risk factors.

Materials And Methods: We retrospectively investigated subjects who underwent screening gastroscopy from 2005 to 2017 in a university hospital and were diagnosed with GC. Read More

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February 2021

Association between Toll-like receptor gene polymorphisms and risk of Helicobacter pylori infection: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 May;100(18):e25729

Graduate School, Guangxi University of Chinese Medicine.

Background: There were many case-control studies performed the association between TLRs gene polymorphisms and the correlation of Helicobactor pylori infection, these results were inconformity. Therefore, a comprehensive meta-analysis was performed to evaluate the TLRs gene polymorphism and susceptibility to H. pylori infection. Read More

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Treatment Approach of Refractory : A Comprehensive Review.

J Prim Care Community Health 2021 Jan-Dec;12:21501327211014087

Mayo Clinic, Jacksonville, FL, USA.

is the most common infection in the world and is associated with gastrointestinal and extra-gastrointestinal manifestations, including peptic ulcer disease, gastrointestinal bleeding, and lymphoproliferative disorders. Despite being discovered less than half a century ago, antibiotic resistance, exacerbated by medication non-adherence and inefficacy of proton pump inhibitors, has grown substantially, explaining the rising incidence of refractory infection. In this review, we discuss risk factors, treatment options, surveillance and follow-up, as well as emerging therapies for refractory . Read More

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Randomized, double-blind, placebo-controlled clinical trial on the usefulness of probiotic Lactobacillus reuteri in bismuth-containing quadruple eradication therapy for infection with Helicobacter pylori.

Rev Esp Enferm Dig 2021 May 5. Epub 2021 May 5.

Aparato Digestivo, Hospital Virgen Macarena, España.

Introduction: The primary goal of this study was to compare gastrointestinal symptom reduction in patients on bismuth-containing quadruple eradication therapy supplemented with Lactobacillus reuteri strains (DSM 17938 and ATCC PTA 6475) or placebo.

Materials And Methods: This was randomized, double-blind, parallel-arm, placebo-controlled clinical trial. Patients received first-line an eradication regimen based on bismuth subcitrate potassium, metronidazole, tetracycline hydrochloride (three-in-one capsules), and omeprazole 40 mg twice a day for ten days, plus a probiotic or placebo tablet for 30 days. Read More

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Helicobacter pylori eradication improves motor fluctuations in advanced Parkinson's disease patients: A prospective cohort study (HP-PD trial).

PLoS One 2021 4;16(5):e0251042. Epub 2021 May 4.

Faculty of Medicine, Department of Internal Medicine, Gastroenterology Unit, Thammasat University, Pathumthani, Thailand.

Background: Helicobacter pylori (HP) is a bacterium associated with many gastrointestinal (GI) diseases and has shown a high prevalence in Parkinson's disease (PD). As HP-associated GI dysfunction could affect L-dopa (levodopa) absorption, HP eradication might improve the clinical response and decrease motor fluctuations.

Methods: A prospective cohort study was conducted on the clinical symptoms of PD patients with motor fluctuations. Read More

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United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on functional dyspepsia.

United European Gastroenterol J 2021 Apr;9(3):307-331

Gastroenterology Unit, Departmento of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.

Background: Functional dyspepsia (FD) is one of the most common conditions in clinical practice. In spite of its prevalence, FD is associated with major uncertainties in terms of its definition, underlying pathophysiology, diagnosis, treatment, and prognosis.

Methods: A Delphi consensus was initiated with 41 experts from 22 European countries who conducted a literature summary and voting process on 87 statements. Read More

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Engineering L7Ae for RNA-Only Delivery Kill Switch Targeting CMS2 Type Colorectal Cancer Cells.

ACS Synth Biol 2021 May 3. Epub 2021 May 3.

Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China.

The lack of specific-targeting therapy to precisely identify and kill malignant cells while sparing others is a great challenge in colorectal cancer (CRC) treatment. In the era of molecular classification of tumors, CRC has been grouped into four Consensus Molecular Subtypes. Accounting for 37% of all types, the CMS2 group (canonical type) shows distinguishing features: WNT and MYC signaling activation. Read More

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Helicobacter pylori induces gastric cancer via down-regulating miR-375 to inhibit dendritic cell maturation.

Helicobacter 2021 May 3:e12813. Epub 2021 May 3.

School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.

Background: Recent studies and clinical samples have demonstrated that Helicobacter pylori could induce the downregulation of miR-375 in the stomach and promote gastric carcinogenesis. However, whether the immune cells are affected by Helicobacter pylori due to the downregulation of miR-375 is unclear.

Materials And Methods: In this study, we constructed an overexpression and knockdown of miR-375 and Helicobacter pylori infection cell models in vitro. Read More

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Adaptation to the reality of Latin America of the NASPGHAN/ESPGHAN 2016 Guidelines on the Diagnosis, Prevention and Treatment of Helicobacter pylori Infection in Pediatrics.

J Pediatr Gastroenterol Nutr 2021 Apr 28. Epub 2021 Apr 28.

Departamento de Gastroenterología y Nutrición Pediátrica, Escuela de Medicina, Pontificia Universidad Católica de Chile Programa de Microbiología y Micología, ICBM, y Departamento de Pediatría Norte, Facultad de Medicina, Universidad de Chile President LASPGHAN.

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Application of Visual Gene Clip-Based Tailored Therapy for the Eradication of .

Biomed Res Int 2021 10;2021:6150628. Epub 2021 Apr 10.

Department of Gastroenterology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, 518036, China.

Background: eradication with therapies employing a proton pump inhibitor (PPI) and antimicrobial agents is mainly achieved via bacterial susceptibility to antimicrobial agents and the magnitude of acid secretion inhibition. However, annual eradication rates have greatly declined in Mainland China, and therefore, tailored eradication regimens that inhibit acid secretion and employ optimal antimicrobial agents determined based on gene clip testing may improve eradication rates. This study was aimed at evaluating the efficacy of tailored eradication therapy guided by visual gene clip testing for antibiotic resistance and PPI metabolism genotypes. Read More

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Relationship Between Infection and Arteriosclerosis.

Int J Gen Med 2021 23;14:1533-1540. Epub 2021 Apr 23.

Department of Hypertension and Nephrology, NTT Medical Centre, Tokyo, Japan.

It is reported that () infection may be linked to non-digestive tract diseases, such as arteriosclerosis including dyslipidemia, diabetes, obesity, hypertension, and cardiovascular disease. Therefore, we reviewed recent studies available in PubMed dealing with the mechanisms of arteriosclerosis due to infection and the effects of eradication. Conventional studies suggested that infection may increase the risk of arteriosclerosis. Read More

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Heat-killed Helicobacter pylori upregulates NKG2D ligands expression on gastric adenocarcinoma cells via Toll-like receptor 4.

Helicobacter 2021 Apr 29:e12812. Epub 2021 Apr 29.

Faculty of Medicine, Immunology Program, Biomedical Sciences Institute (ICBM), University of Chile, Santiago de Chile, Chile.

Background: Natural killer (NK) cells are paramount for immunity against infectious agents and tumors. Their cytokine and cytolytic responses can be mediated by natural killer group 2, member D (NKG2D), an activating receptor whose ligands (NKG2DL) expression is induced in conditions of cell stress and malignant transformation. Since sustained expression of NKG2DL MICA is related to lower survival rates in gastric adenocarcinoma patients, and Helicobacter pylori infection contributes to tumorigenesis; we asked whether H. Read More

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Role in staging and prognostic value of pretherapeutic F-18 FDG PET/CT in patients with gastric MALT lymphoma without high-grade transformation.

Sci Rep 2021 Apr 29;11(1):9243. Epub 2021 Apr 29.

Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

The purpose of this retrospective study was to investigate the role in staging and prognostic value of pretherapeutic fluorine-18-fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET)/computed tomography (CT) in patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma without high-grade transformation (HT). We retrospectively reviewed 115 consecutive patients with histopathologically confirmed gastric MALT lymphoma without HT who underwent pretherapeutic F-18 FDG PET/CT. Kaplan-Meier and Cox proportional-hazards regression analyses were used to identify independent prognostic factors for disease free survival (DFS) among 13 clinical parameters and three PET parameters. Read More

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The Roles of IL-17, IL-21, and IL-23 in the Infection and Gastrointestinal Inflammation: A Review.

Toxins (Basel) 2021 04 28;13(5). Epub 2021 Apr 28.

Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, Indonesia.

Although millions of people have been infected by (), only a small proportion of infected individuals will develop adverse outcomes, ranging from chronic gastritis to gastric cancer. Advanced development of the disease has been well-linked with chronic inflammation, which is significantly impacted by the adaptive and humoral immunity response. From the perspective of cellular immunity, this review aims to clarify the intricate axis between IL-17, IL-21, and IL-23 in -related diseases and the pathogenesis of inflammatory gastrointestinal diseases. Read More

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MicroRNA Changes in Gastric Carcinogenesis: Differential Dysregulation during and EBV Infection.

Genes (Basel) 2021 Apr 19;12(4). Epub 2021 Apr 19.

Medizinische Klinik 2, Helios Universitätsklinikum Wuppertal, 42283 Wuppertal, Germany.

Despite medical advances, gastric-cancer (GC) mortality remains high in Europe. Bacterial infection with () and viral infection with the Epstein-Barr virus (EBV) are associated with the development of both distal and proximal gastric cancer. Therefore, the detection of these infections and the prediction of further cancer development could be clinically significant. Read More

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Outer Membrane Vesicle Production by Represents an Approach for the Delivery of Virulence Factors CagA, VacA and UreA into Human Gastric Adenocarcinoma (AGS) Cells.

Int J Mol Sci 2021 Apr 11;22(8). Epub 2021 Apr 11.

Institute of Molecular Medicine, National Tsing Hua University, Hsinchu 30013, Taiwan.

infection is the etiology of several gastric-related diseases including gastric cancer. Cytotoxin associated gene A (CagA), vacuolating cytotoxin A (VacA) and α-subunit of urease (UreA) are three major virulence factors of , and each of them has a distinct entry pathway and pathogenic mechanism during bacterial infection. can shed outer membrane vesicles (OMVs). Read More

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Indications and Findings of Upper Endoscopies in Males and Females, Are They the Same or Different?

J Clin Med 2021 Apr 11;10(8). Epub 2021 Apr 11.

Soroka University Medical Center, Faculty of Health Sciences, The Institute of Gastroenterology and Hepatology, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel.

Sex and gender can affect the prevalence and prognosis of diseases. Our aim was to assess similarities and differences for males and females who underwent an upper endoscopy, with regards to indications and results. We reviewed all upper endoscopy reports from 2012 to 2016. Read More

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Vegetable Extracts and Nutrients Useful in the Recovery from Infection: A Systematic Review on Clinical Trials.

Molecules 2021 Apr 14;26(8). Epub 2021 Apr 14.

Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy.

() infections affect almost half of the world's population, with gradually increasing incidence in developed countries. Eradication of may provide significant benefits to the affected individual by healing a number of gastrointestinal and extra-digestive disorders. But due to increased microbial resistance and lack of patient adherence to the therapy, the eradication rate of is below 80% with current pharmacological therapies. Read More

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Role of Bacterial and Viral Pathogens in Gastric Carcinogenesis.

Cancers (Basel) 2021 Apr 14;13(8). Epub 2021 Apr 14.

Department of Surgery, University of Miami, Miami, FL 33136, USA.

Gastric cancer (GC) is one of the deadliest malignancies worldwide. In contrast to many other tumor types, gastric carcinogenesis is tightly linked to infectious events. Infections with () bacterium and Epstein-Barr virus (EBV) are the two most investigated risk factors for GC. Read More

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The Role of Formyl Peptide Receptors in Permanent and Low-Grade Inflammation: Infection as a Model.

Int J Mol Sci 2021 Apr 2;22(7). Epub 2021 Apr 2.

Department of Microbiology and Molecular Medicine, University of Geneva Medical School, 1211 Genèva, Switzerland.

Formyl peptide receptors (FPRs) are cell surface pattern recognition receptors (PRRs), belonging to the chemoattractant G protein-coupled receptors (GPCRs) family. They play a key role in the innate immune system, regulating both the initiation and the resolution of the inflammatory response. FPRs were originally identified as receptors with high binding affinity for bacteria or mitochondria N-formylated peptides. Read More

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Upper Gastrointestinal Lesions during Endoscopy Surveillance in Patients with Lynch Syndrome: A Multicentre Cohort Study.

Cancers (Basel) 2021 Apr 1;13(7). Epub 2021 Apr 1.

Department of Hepatogastroenterology and Digestive Oncology, Trousseau University Hospital, CHU de Tours, CEDEX 09, 37044 Tours, France.

Background: Patients with Lynch syndrome are at increased risk of gastric and duodenal cancer. Upper gastrointestinal endoscopy surveillance is generally proposed, even though little data are available on upper gastrointestinal endoscopy in these patients. The aim of this retrospective study was to evaluate the prevalence and incidence of gastrointestinal lesions following upper gastrointestinal endoscopy examination in Lynch patients. Read More

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Ultrasonographic assessment of femoral cartilage thickness in patients with Helicobacter pylori infection.

Int J Clin Pract 2021 Apr 29:e14276. Epub 2021 Apr 29.

Department of Gastroenterology, Sancaktepe Şehit Prof Dr Ilhan Varank Training and Research Hospital, Istanbul, Turkey.

Objectives: Helicobacter pylori is a major cause of gastritis and a potential trigger of inflammatory disease. The effect of H pylori infection on distal femoral cartilage has yet to be evaluated. The aim of this study was to evaluate femoral cartilage thickness in patients with H pylori infection and to find whether this infection affects femoral cartilage thickness. Read More

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Dysbiotic gut microbiota in inflammatory rosacea patients: another clue towards the existence of a brain-gut-skin axis.

Br J Dermatol 2021 Apr 29. Epub 2021 Apr 29.

Dermatology Department, Ramon y Cajal University Hospital, University of Alcala, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.

Rosacea is a chronic inflammatory disease that primarily affects young and middle-aged Caucasian women. Its etiology is multifactorial and appears to be determined by genetic predisposition, alteration of the neurovascular and immune response, as well as an altered dialogue with the microbiota. Additionally, the disease has been linked to gastrointestinal disorders such as Helicobacter pylori infection or small intestine bacterial overgrowth and even neurological disorders such as Parkinson's disease, revealing the existence of a brain-gut-skin axis. Read More

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Helicobacter pylori infection as a potential favorable factor for immune checkpoint inhibitor therapy for gastric cancer.

Invest New Drugs 2021 Apr 29. Epub 2021 Apr 29.

Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230000, China.

Gastric cancer (GC) has the third highest rate of cancer incidence and mortality worldwide. First-line immune checkpoint inhibitor (ICI) therapy for advanced GC led to landmark breakthroughs, but which GC patients are most likely to benefit from ICI therapy needs to be investigated in depth and identified via valuable biomarkers. In this letter, we describe superior outcomes in Asian patients than in North American and European patients treated with ICI therapy, and we speculate that positive H. Read More

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Engineered endolysin-based "artilysins" for controlling the gram-negative pathogen Helicobacter pylori.

AMB Express 2021 Apr 28;11(1):63. Epub 2021 Apr 28.

Wanbang Pharmatech Co., Ltd, Xuzhou, 221004, China.

Helicobacter pylori infection can cause a variety of gastrointestinal diseases. In severe cases, there is a risk of gastric cancer. Antibiotics are often used for clinical treatment of H. Read More

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EPIYA motifs of genotypes and gastrointestinal diseases in the Iranian population: a systematic review and meta-analysis.

New Microbes New Infect 2021 May 16;41:100865. Epub 2021 Mar 16.

Department of Microbiology and Virology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran.

is one of the best risk factors for gastric cancer. Recent studies have examined the relationship between virulence factors, in particular CagA toxin, and the development of gastrointestinal diseases. According to the literature, there is a significant relationship between the polymorphism of -EPIYA motifs and progression to severe clinical outcomes. Read More

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Arq Gastroenterol 2021 Jan-Mar;58(1):39-47

Universidade Federal de Minas Gerais, Faculdade de Medicina, Programa de Pós-Graduação em Ciências Aplicadas à Saúde do Adulto, Belo Horizonte, MG, Brasil.

Background: H. pylori chronic atrophic gastritis is a premalignant lesion, and its staging, according to OLGA and OLGIM systems aims to identify patients at increased risk of developing gastric cancer and optimize their follow-up. GastroPanel®, serum biomarkers panel including pepsinogen I (PGI), pepsinogen II (PGII), Gastrin 17 (G17) and anti- H. Read More

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Helicobacter pylori and colorectal neoplasms: a concise review.

Arq Gastroenterol 2021 Jan-Mar;58(1):114-119

Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, MG, Brasil.

Helicobacter pylori is the main etiological agent of all malignant tumors caused by an infectious disease. It is a major, at times dominant, factor in the pathogenesis of a large spectrum of diseases such as acute and chronic gastritis, gastric and duodenal ulcers, gastric carcinoma, and lymphoma. Epidemiological and experimental studies suggest that H. Read More

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Prevalence, clinical features, and esophagogastroduodenoscopy (EGD) findings of non-Helicobacter pylori Helicobacter infection: A study of 50 cases at a single facility in Japan.

Helicobacter 2021 Apr 27:e12811. Epub 2021 Apr 27.

Department of Internal Medicine, Showainan General Hospital, Komagane, Japan.

Background And Aim: There are only a few reports of non-Helicobacter pylori Helicobacter (NHPH) gastritis in Japanese patients. We aimed to examine its prevalence, clinical features, and esophagogastroduodenoscopy (EGD) findings based on 50 patients encountered in one facility.

Materials And Methods: Subjects were all patients who had undergone gastric mucosal biopsy endoscopically at Kenwakai Hospital for approximately 10 years. Read More

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Evaluation of parameters associated with growth retardation in children with coeliac disease.

J Paediatr Child Health 2021 Apr 28. Epub 2021 Apr 28.

Department of Pharmacology, Bahcesehir University, School of Medicine, Istanbul, Turkey.

Aims: Coeliac disease (CD) is an autoimmune disorder with a prevalence ≤2% that causes an immune reaction to gluten. Growth retardation (GR) generally accompanies CD due to gastrointestinal complications and should be treated as early as possible along with initiation of a gluten-free diet. The aim of this study was to determine the indicators of GR in patients with CD. Read More

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