22,690 results match your criteria Helicobacter Pylori Infection


Analysis of core protein clusters identifies candidate variable sites conferring metronidazole resistance in .

Gastroenterol Rep (Oxf) 2019 Feb 2;7(1):42-49. Epub 2019 Jan 2.

The Marshall Centre for Infectious Diseases Research and Training, University of Western Australia, Perth, Western Australia, Australia.

Background: Metronidazole is one of the first-line drugs of choice in the standard triple therapy used to eradicate infection. Hence, the global emergence of metronidazole resistance in poses a major challenge to health professionals. Inactivation of RdxA is known to be a major mechanism of conferring metronidazole resistance in However, metronidazole resistance can also arise in strains expressing functional RdxA protein, suggesting that there are other mechanisms that may confer resistance to this drug. Read More

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http://dx.doi.org/10.1093/gastro/goy048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375344PMC
February 2019

Association of host immunity with infection in recurrent gastric cancer.

Infect Agent Cancer 2019 11;14. Epub 2019 Feb 11.

2Gastroenterology and Hepatology, Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

Background: infection is associated with the incidence of gastric cancer. Endoscopic resection has been developed as a proper technique to treat early stage of gastric cancer. However, some patients develop recurrent gastric cancer within 5 years after endoscopic treatment. Read More

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http://dx.doi.org/10.1186/s13027-019-0221-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371572PMC
February 2019

Duodenal Ulceration following Holmium Laser Lithotripsy.

Case Rep Gastroenterol 2019 Jan-Apr;13(1):12-16. Epub 2019 Jan 10.

Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

The epidemiology of peptic ulcer disease (PUD) has changed considerably in the last several decades. Previously a chronic disease characterized by frequent recurrences with a high rate of surgical interventions, it is now largely a self-limited disease that is medically managed. The role of acid suppression was widely recognized as being important in the pathogenesis of PUD in the 19th century, while it was not until the 1980s and 1990s that the importance of infection was identified. Read More

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http://dx.doi.org/10.1159/000485237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381914PMC
January 2019

The eradication of Helicobacter pylori to prevent gastric cancer: a critical appraisal.

Expert Rev Gastroenterol Hepatol 2019 Jan 13;13(1):17-24. Epub 2018 Nov 13.

f Department of Medicine , Michael E. DeBakey VA Medical Center, and Baylor College of Medicine , Houston , TX , USA.

Introduction: Gastric cancer is one of the top causes of cancer-related death worldwide. How to eliminate gastric cancer is an urgent public-health issue. Areas covered: In this review, we present up-to-date results of studies on gastric cancer prevention through the eradication of Helicobacter pylori and discuss strategies and obstacles for the implementation of population-wide screening and treatment of this pathogen to prevent gastric cancer. Read More

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http://dx.doi.org/10.1080/17474124.2019.1542299DOI Listing
January 2019

Duodenal low-grade inflammation and expression of tight junction proteins in functional dyspepsia.

Neurogastroenterol Motil 2019 Feb 20:e13576. Epub 2019 Feb 20.

Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.

Background: Duodenal changes in functional dyspepsia (FD) might be related to the development of symptoms. However, relationships among low-grade inflammation, Helicobacter pylori infection, and protein expression by tight junctions (TJs) in the duodenum are unclear. We therefore aimed to determine whether duodenal inflammation and genes associated with TJ proteins are associated with FD. Read More

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http://dx.doi.org/10.1111/nmo.13576DOI Listing
February 2019

Characterization of digestive disorders of patients with chronic Chagas disease in Cochabamba, Bolivia.

Heliyon 2019 Feb 7;5(2):e01206. Epub 2019 Feb 7.

Fundación CEADES, Cochabamba, Bolivia.

Background: Chagas disease (CD) is endemic in Latin America and particularly common in Bolivia, but there is little information on the characteristics of chronic digestive involvement.

Objectives: To determine the prevalence and characterize digestive manifestations in chronic CD patients in Cochabamba, Bolivia.

Methods: Eighty-five -seropositive individuals with or without digestive symptoms (G1 group), and fifteen -seronegative patients with similar digestive symptoms to those seen in CD (G2 group) were included in the study. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369243PMC
February 2019

Activation of CD3 T cells by Helicobacter pylori DNA vaccines in potential immunotherapy of gastric carcinoma.

Cancer Biol Ther 2019 Feb 20:1-11. Epub 2019 Feb 20.

a Department of Oncology , Jinling Hospital, Nanjing University Clinical School of Medicine , Nanjing , China.

Most of gastric carcinoma (GC) is attributed to infection by Helicobacter pylori (H. pylori) but there is increasing evidence that the positive H. pylori status correlates with better prognosis in GC. Read More

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http://dx.doi.org/10.1080/15384047.2019.1579957DOI Listing
February 2019

Increased serum gastrin in patients with different clinical forms of Chagas disease coinfected with Helicobacter pylori.

Rev Inst Med Trop Sao Paulo 2019 Feb 14;61:e7. Epub 2019 Feb 14.

Universidade Federal do Triângulo Mineiro, Instituto de Ciências Biológicas e Naturais, Uberaba, Minas Gerais, Brazil.

Trypanosoma cruzi and Helicobacter pylori (HP) are pathogens that cause chronic diseases and have been associated with hypergastrinemia. The aim of this study was to evaluate the fasting gastrin levels in patients with different clinical forms of Chagas disease (CD), coinfected or not by HP. The enrolled individuals were outpatients attending at the university hospital. Read More

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http://dx.doi.org/10.1590/S1678-9946201961007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376922PMC
February 2019

GASTRIC FUNDIC GLAND POLYPS: CAN HISTOLOGY BE USEFUL TO PREDICT PROTON PUMP INHIBITORS USE?

Arq Gastroenterol 2018 Oct-Dec;55(4):380-384

Universidade Federal de Sergipe, Departamento de Medicina, Aracaju, SE, Brasil.

Background: Fundic gland polyps allegedly increased in frequency in recent decades, and had attracted great attention due to possible association with prolonged proton pump inhibitor therapy. Prolonged use of this drug could cause parietal cell hyperplasia, obstruction of glandular lumen and cystic dilation of the gland.

Objective: This study aims to analyze clinical and pathological features of fundic gland polyps in patients with and without proton pump inhibitor therapy in a selected population from Brazil. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-82DOI Listing

Helicobacter pylori infection and gastric cancer biology: tempering a double-edged sword.

Cell Mol Life Sci 2019 Feb 19. Epub 2019 Feb 19.

Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, 11527, Athens, Greece.

Helicobacter pylori (H. pylori) infection affects an estimated 4.4 billion people globally. Read More

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http://link.springer.com/10.1007/s00018-019-03044-1
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http://dx.doi.org/10.1007/s00018-019-03044-1DOI Listing
February 2019
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-induced DNA Methylation as an Epigenetic Modulator of Gastric Cancer: Recent Outcomes and Future Direction.

Pathogens 2019 Feb 13;8(1). Epub 2019 Feb 13.

Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, University of Sharjah, Sharjah 27272, UAE.

Gastric cancer is ranked fifth in cancer list and has the third highest mortality rate. is a class I carcinogen and a predominant etiological factor of gastric cancer. infection may induce carcinogenesis via epigenetic alterations in the promoter region of various genes. Read More

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http://dx.doi.org/10.3390/pathogens8010023DOI Listing
February 2019

Half-dose clarithromycin-containing bismuth quadruple therapy is effective and economical in treating Helicobacter pylori infection: A single-center, open-label, randomized trial.

Helicobacter 2019 Feb 19:e12566. Epub 2019 Feb 19.

Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: Clarithromycin-containing bismuth quadruple therapy has been recommended as the first-line therapy for H pylori infection in China. However, its expensive cost and high antibiotic-related adverse reactions are always haunting us. To find a safer, more cost-effective, and high eradicative strategy for Helicobacter treatment, we investigated the efficacy of 14-day bismuth quadruple therapy and different doses of clarithromycin in the first-line treatment. Read More

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http://dx.doi.org/10.1111/hel.12566DOI Listing
February 2019

Helicobacter pylori infection increases risk of incident metabolic syndrome and diabetes: A cohort study.

PLoS One 2019 19;14(2):e0208913. Epub 2019 Feb 19.

Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.

Emerging studies have shed light on the association between Helicobacter pylori (HP) infection and cardiometabolic risk. However, there is no evidence to support a causal link for the relationship in the general population. Our aim was to determine whether HP infection is associated with the risks of incident type II diabetes mellitus (DM) in a population-based cohort consisting of adults from the general population. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208913PLOS
February 2019

Epigenetic downregulation of MUC17 by H. pylori infection facilitates NF-κB-mediated expression of CEACAM1-3S in human gastric cancer.

Gastric Cancer 2019 Feb 18. Epub 2019 Feb 18.

Laboratory of Molecular Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, 100142, People's Republic of China.

Background And Aims: Helicobacter pylori invades the mucosal barrier and infects the mucins of gastric epithelial cells. However, whether gastric carcinogenesis caused by H. pylori infection involves the membrane-bound mucins is unclear. Read More

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http://dx.doi.org/10.1007/s10120-019-00932-0DOI Listing
February 2019

Role of abnormal microRNA expression in Helicobacter pylori associated gastric cancer.

Crit Rev Microbiol 2019 Feb 19:1-13. Epub 2019 Feb 19.

a The First laboratory of cancer institute , First Hospital of China Medical University , Shenyang , China.

Epidemiological studies have shown that Helicobacter pylori (HP) infection is a risk factor for gastric cancer (GC). HP infection may induce the release of pro-inflammatory mediators, and abnormally increase the level of reactive oxygen species (ROS), nitric oxide (NO), and cytokines in mucosal epithelial cells of the stomach. However, the specific mechanism underlying the pathogenesis of HP-associated GC is still poorly understood. Read More

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https://www.tandfonline.com/doi/full/10.1080/1040841X.2019.1
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http://dx.doi.org/10.1080/1040841X.2019.1575793DOI Listing
February 2019
2 Reads

Tipping the Scale Toward Gastric Disease: A Host-Pathogen Genomic Mismatch?

Curr Genet Med Rep 2018 Dec 10;6(4):199-207. Epub 2018 Oct 10.

Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.

Purpose Of Review: Chronic infection with infection is necessary but not sufficient to initiate development of intestinal-type gastric adenocarcinoma. It is not clear what additional factors tip the scale from commensal bacteria towards a pathogen that facilitates development of gastric cancer. Genetic variants in both the pathogen and host have been implicated, but neither alone explains a substantial portion of disease risk. Read More

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http://dx.doi.org/10.1007/s40142-018-0153-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373874PMC
December 2018

Alternative eradication regimens for infection in Indonesian regions with high metronidazole and levofloxacin resistance.

Infect Drug Resist 2019 31;12:345-358. Epub 2019 Jan 31.

Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu 879-5593, Japan,

Background: The prevalence of resistance to metronidazole and clarithromycin is high in Indonesia. Moreover, the increasing levofloxacin resistance rates in the absence of bismuth treatment in Indonesia has led to the use of other antibiotics as alternative regimens.

Methods: We determined the minimum inhibitory concentrations (MICs) of five alternative antibiotics for (rifaximin, rifabutin, furazolidone, garenoxacin, and sitafloxacin) using the agar dilution method and assessed mutations associated with antibiotic resistance using next-generation sequencing. Read More

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http://dx.doi.org/10.2147/IDR.S187063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362932PMC
January 2019

Haemorrhagic gastric hyperplastic polyps associated with long-term use of proton pump inhibitor in a case without Helicobacter pylori infection.

J Clin Pharm Ther 2019 Feb 17. Epub 2019 Feb 17.

Department of Gastroenterology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.

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http://dx.doi.org/10.1111/jcpt.12819DOI Listing
February 2019
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Ureido-modified carboxymethyl chitosan-graft-stearic acid polymeric nano-micelles as a targeted delivering carrier of clarithromycin for Helicobacter pylori: Preparation and in vitro evaluation.

Int J Biol Macromol 2019 Feb 14;129:686-692. Epub 2019 Feb 14.

College of Marine Life Sciences, Ocean University of China, 266003 Qingdao, China. Electronic address:

The effect of antibiotics in the stomach for curing Helicobacter pylori infection is hampered by the adverse gastric environment and low bioavailability of the administered drugs. Concerning these challenges, a polymeric nano-micelle was developed. Initially, carboxymethyl chitosan (CMCS) was hydrophobically modified with stearic acid (SA), and the obtained CMCS-g-SA co-polymers was further conjugated with urea to acquire U-CMCS-g-SA co-polymers. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.01.227DOI Listing
February 2019

Circulating CD14CD163CD209 M2-like monocytes are associated with the severity of infection in Helicobacter pylori-positive patients.

Mol Immunol 2019 Feb 13;108:13-22. Epub 2019 Feb 13.

Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun 130021, China; Key Laboratory of Zoonosis Research, Ministry of Education, The First Hospital, Jilin University, Changchun 130021, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China. Electronic address:

Helicobacter pylori (H. pylori) initiates a robust host immune response and subsequently results in chronic inflammation in the gastric mucosa. This study monitored the circulating monocyte subsets and measured the plasma levels of IL-10 and IL-12 in response to H. Read More

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http://dx.doi.org/10.1016/j.molimm.2019.01.017DOI Listing
February 2019
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Enrichment of CLDN18-ARHGAP fusion gene in gastric cancers in young adults.

Cancer Sci 2019 Feb 16. Epub 2019 Feb 16.

Division of Screening for Molecular Target of Cancer, Graduate School of Medicine, Tohoku University, Sendai, Japan.

Gastric cancer in young adults has been pointed out to comprise a subgroup associated with distinctive clinicopathological features, including an equal gender distribution, advanced disease and diffuse-type histology. Comprehensive molecular analyses of gastric cancers have led to molecular-based classifications and to specific and effective treatment options available. The molecular traits of gastric cancers in young adults await investigations, which should provide a clue to explore therapeutic strategies. Read More

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http://dx.doi.org/10.1111/cas.13967DOI Listing
February 2019
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Update on the Diagnosis and Management of Gastric Intestinal Metaplasia in the USA.

Dig Dis Sci 2019 Feb 15. Epub 2019 Feb 15.

Division of Gastroenterology and Hepatology, University of Virginia, P.O. Box 800708, Charlottesville, VA, 22908, USA.

Gastric intestinal metaplasia (GIM) is a premalignant condition that can lead to intestinal-type gastric adenocarcinoma. It is characterized by a change in the gastric mucosa to a small-intestinal phenotype. Infection with Helicobacter pylori is the most common factor associated with GIM. Read More

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http://dx.doi.org/10.1007/s10620-019-05526-5DOI Listing
February 2019
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A Helicobacter pylori screening and treatment program to eliminate gastric cancer among junior high school students in Saga Prefecture: a preliminary report.

J Gastroenterol 2019 Feb 15. Epub 2019 Feb 15.

Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga-shi, 849-8501, Saga, Japan.

Background: To present the strategies and preliminary findings of the first 3 years after implementing a Helicobacter pylori screening and eradication program to prevent gastric cancer in Saga Prefecture.

Methods: A screening and treatment program to eradicate H. pylori from third-grade junior high students was started in Saga Prefecture in 2016, using local governmental grants. Read More

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http://dx.doi.org/10.1007/s00535-019-01559-9DOI Listing
February 2019
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A 14 day esomeprazole- and amoxicillin-containing high-dose dual therapy regimen achieves a high eradication rate as first-line anti-Helicobacter pylori treatment in Taiwan: a prospective randomized trial.

J Antimicrob Chemother 2019 Feb 14. Epub 2019 Feb 14.

Division of Hepatogastroenterology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.

Background: The first-line eradication rate of standard triple therapy for Helicobacter pylori infection has declined to <80%, and alternative therapies with >90% success rates are needed. Inconsistent eradication rates were reported for proton pump inhibitor- and amoxicillin-containing high-dose dual therapy.

Objectives: We performed a prospective, randomized controlled study to assess the efficacy of esomeprazole- and amoxicillin-containing high-dose dual therapy and investigated the influencing clinical factors. Read More

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http://dx.doi.org/10.1093/jac/dkz046DOI Listing
February 2019
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Meta-analysis of three-in-one single capsule bismuth-containing quadruple therapy for the eradication of Helicobacter pylori.

Helicobacter 2019 Feb 14:e12570. Epub 2019 Feb 14.

Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad Autónoma de Madrid (UAM), Madrid, Spain.

Background: Bismuth-containing quadruple therapy has been suggested as first-line and rescue alternative for Helicobacter pylori eradication. Our objective was to perform a meta-analysis evaluating the efficacy and safety of single capsule Pylera (bismuth, metronidazole, and tetracycline) plus a proton-pump inhibitor (PPI) in any line of treatment.

Methods: Studies were selected up to October 2018. Read More

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http://dx.doi.org/10.1111/hel.12570DOI Listing
February 2019
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Helicobacter pylori infection as a risk factor for serum bilirubin change and less favourable lipid profiles: a hospital-based health examination survey.

BMC Infect Dis 2019 Feb 14;19(1):157. Epub 2019 Feb 14.

Department of Endocrinology, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.

Background: Helicobacter pylori infection is associated with several extragastric conditions including dyslipidemia and metabolic syndrome. This study aimed to investigate additional metabolic parameters associated with H. pylori infection in a Chinese population. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3787-8DOI Listing
February 2019
5 Reads

High dose dual therapy versus bismuth quadruple therapy for Helicobacter pylori eradication treatment: A systematic review and meta-analysis.

Medicine (Baltimore) 2019 Feb;98(7):e14396

Department of Gastroenterology, Sichuan Academy of Science & Sichuan Provincial People's Hospital, University of Electronic Science and Technology, Chengdu, China.

Aim: The aim of this study was to perform a systematic review and meta-analysis on high-dose dual therapy (HDDT) versus bismuth quadruple therapy (BQT) for Helicobacter pylori infection.

Methods: Comparing HDDT to BQT were identified from PubMed, EMBASE, Cochrane library, CNKI, and Wanfang databases in Chinese up to March 2018. Statistical analyses were conducted using Review Manager 5. Read More

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http://dx.doi.org/10.1097/MD.0000000000014396DOI Listing
February 2019

Effects of Ankaferd Hemostat on Helicobacter pylori strains and antibiotic resistance

Turk J Med Sci 2019 Feb 11;49(1):347-355. Epub 2019 Feb 11.

Background/aim: Ankaferd hemostat (ABS; Ankaferd blood stopper, İstanbul, Turkey) is a folkloric medicinal plant extract. The aim of this study was to determine the effect of Ankaferd hemostat (ABS) on the fate of Helicobacter pylori strains. The study also aims to determine alterations in the antimicrobial resistance of three different H. Read More

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http://dx.doi.org/10.3906/sag-1807-206DOI Listing
February 2019
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Helicobacter pylori and nutrition: a bidirectional communication.

Minerva Gastroenterol Dietol 2019 Feb 12. Epub 2019 Feb 12.

Unit of Dietetics and Clinical Nutrition, Città della Salute e della Scienza, Turin, Italy.

Helicobacter pylori (HP) is a gram negative flagellated pathogen acid-resistant bacterium; it belongs to the order Campylobacterales that is wide spread all over the world, infecting more than 50% of the world population. HP infection is etiologically associated with non-atrophic and atrophic gastritis, peptic ulcer and with 3 to 6-fold increased relative risk for developing gastric adenocarcinoma and mucosa-associated lymphoid tissue (MA LT) lymphoma. For this reason HP is recognized by the World Health Organization as a Class I human carcinogen. Read More

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https://www.minervamedica.it/index2.php?show=R08Y9999N00A190
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http://dx.doi.org/10.23736/S1121-421X.19.02568-6DOI Listing
February 2019
3 Reads

Treatment of Helicobacter pylori infection in Piedmont: new preliminary data on prescription attitudes.

Minerva Gastroenterol Dietol 2019 Feb 12. Epub 2019 Feb 12.

Department of Surgical Sciences, University of Turin, Turin, Italy -

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http://dx.doi.org/10.23736/S1121-421X.19.02550-9DOI Listing
February 2019
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Helicobacter pylori infection and Parkinson's disease.

Authors:
Giovanni C Actis

Minerva Gastroenterol Dietol 2019 Feb 11. Epub 2019 Feb 11.

The Medical Center Practice Office, Turin, Italy -

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http://dx.doi.org/10.23736/S1121-421X.19.02554-6DOI Listing
February 2019

Autoantibodies to a specific peptide epitope of human Hsp60 (ATVLA) with homology to Helicobacter pylori HspB in H. pylori-infected patients.

APMIS 2019 Mar;127(3):139-149

Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland.

Helicobacter pylori (Hp) may initiate autoimmunity as a result of molecular mimicry. The aim of this study was to compare the level of IgG antibodies to a specific epitope (P1 peptide) of human heat shock protein (Hsp)60 homologous to Hp Hsp60 (HspB) in the sera of healthy donors (HD), patients with Hp-related gastritis or coronary heart disease (CHD), uninfected or with Hp infection confirmed by rapid urease test, histological examination (dyspeptic patients) the C urea breath test ( C UBT), and anti-Hp antibodies (healthy donors, CHD patients). The Anti-P1 IgG induction by Hp was verified by adsorption of sera with these bacteria and by experimental immunization of Caviae porcellus with Hp. Read More

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http://doi.wiley.com/10.1111/apm.12925
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http://dx.doi.org/10.1111/apm.12925DOI Listing
March 2019
4 Reads

N-acetylcysteine as an adjuvant therapy for Helicobacter pylori eradication.

Cochrane Database Syst Rev 2019 Feb 12;2:CD012357. Epub 2019 Feb 12.

Department of Evidence-Based Medicine, Intensive Care, Gastroenterology, Petrópolis Medical School, Av Barao do Rio Branco, 1003, Petrópolis, RJ, Brazil, 25680-120.

Background: Helicobacter pylori (H pylori) is one of the most common pathogens to establish and cause infection in human beings, affecting about 50% of the world's population. Prevalence may be as high as 83% in Latin American countries and as low as 17% in North America. Approximately 20% of infected people will manifest disease; people at high risk include those who live in low- and middle-income countries with poor sanitary conditions, since the mechanism of transmission seems to be oral-oral or faecal-oral (mostly during infancy). Read More

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http://dx.doi.org/10.1002/14651858.CD012357.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370586PMC
February 2019
6 Reads

Correlation between macrophage migration inhibitory factor and autophagy in Helicobacter pylori-associated gastric carcinogenesis.

PLoS One 2019 11;14(2):e0211736. Epub 2019 Feb 11.

Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul, South Korea.

The role of macrophage migration inhibitory factor (MIF) and autophagy in gastric cancer is not clear. We determined H. pylori infection status of the subjects and investigated the expression of MIF and autophagy markers (Atg5, LC3A and LC3B) in human gastric tissue at baseline. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211736PLOS
February 2019
1 Read
3.234 Impact Factor

Association between atrial fibrillation and Helicobacter pylori.

Clin Res Cardiol 2019 Feb 8. Epub 2019 Feb 8.

Department of Cardiothoracic Surgery, Cardiovascular Research Institute Maastricht -CARIM, Maastricht University Medical Centre, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.

The connection between atrial fibrillation (AF) and H. pylori (HP) infection is still matter of debate. We performed a systematic review and metanalysis of studies reporting the association between AF and HF. Read More

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http://dx.doi.org/10.1007/s00392-019-01418-wDOI Listing
February 2019
1 Read

Rifabutin-Based Rescue Therapy for Eradication: A Long-Term Prospective Study in a Large Cohort of Difficult-to-Treat Patients.

J Clin Med 2019 Feb 6;8(2). Epub 2019 Feb 6.

Unit of Gastroenterology, Molinette Hospital, 10123 Turin, Italy.

The most commonly used regimens fail to eradicate () infection in 5⁻10% of patients. Those not cured with treatments based on amoxicillin, clarithromycin, nitroimidazoles, fluoroquinolones, bismuth or tetracycline have no other conventional options thereafter. In this prospective long-term monocentric study, patients who failed to eradicate following treatment with all conventional antibiotics were included. Read More

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http://dx.doi.org/10.3390/jcm8020199DOI Listing
February 2019
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Helicobacter pylori infection alters gastric and tongue coating microbial communities.

Helicobacter 2019 Feb 7:e12567. Epub 2019 Feb 7.

The Traditional Chinese Medicine Hospital of Shijiazhuang Affiliated to Hebei University of Chinese Medicine, Shijiazhuang, China.

Objective: Infection with Helicobacter pylori (H pylori), especially cytotoxin-associated gene A-positive (CagA+) strains, has been associated with various gastrointestinal and extragastric diseases. The aim of this study was to characterize H pylori-induced alterations in the gastric and tongue coating microbiota and evaluate their potential impacts on human health.

Design: The gastric mucosa and tongue coating specimens were collected from 80 patients with chronic gastritis, and microbiota profiles were generated by 16S rRNA gene sequencing. Read More

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http://doi.wiley.com/10.1111/hel.12567
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http://dx.doi.org/10.1111/hel.12567DOI Listing
February 2019
3 Reads

Intraluminal therapy for Helicobacter pylori infection.

J Gastroenterol Hepatol 2019 Feb 8. Epub 2019 Feb 8.

Division of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan.

Background And Aim: Several strategies have been proposed to increase the eradication rate of Helicobacter pylori. However, the widespread increasing resistance rates to current multiple-dose oral antibiotics therapies call for alternative therapeutic approaches. We aim to develop a novel intraluminal therapy for Helicobacter pylori infection (ILTHPI). Read More

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http://dx.doi.org/10.1111/jgh.14627DOI Listing
February 2019
2 Reads

Helicobacter pylori infection in children: an overview of diagnostic methods.

Eur J Clin Microbiol Infect Dis 2019 Feb 7. Epub 2019 Feb 7.

Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Islamic Republic of Iran.

Children differ from adults regarding Helicobacter pylori (H. pylori) infection in many terms. H. Read More

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http://link.springer.com/10.1007/s10096-019-03502-5
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http://dx.doi.org/10.1007/s10096-019-03502-5DOI Listing
February 2019
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Comparison the cost-efficacy of furazolidone-based versus clarithromycin-based quadruple therapy in initial treatment of Helicobacter pylori infection in a variable clarithromycin drug-resistant region, a single-center, prospective, randomized, open-label study.

Medicine (Baltimore) 2019 Feb;98(6):e14408

Department of Gastroenterology and Hepatology.

Helicobacter pylori (Hp) drug resistant rate to clarithromycin (CLA) has increased to 20% to 50%, which cause concerns regarding its effectiveness in eradicating Hp, we aim to evaluate the cost-effectiveness of CLA-based versus furazolidone (FZD)-based quadruple therapy, and assess factors that affect anti-Hp efficacy.One hundred eighty-five patients were enrolled in this single-center, prospective, randomized, open-label study. In FZD group, 92 patients were treated with FZD plus esomeprazole, bismuth potassium citrate, and amoxicillin for 14 days. Read More

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http://dx.doi.org/10.1097/MD.0000000000014408DOI Listing
February 2019
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Helicobacter pylori infection and risk of salmonella infection.

Medicine (Baltimore) 2019 Feb;98(6):e14335

Hepatology, Gastroenetrology and Infectious Diseases Department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh.

Helicobacter pylori (H pylori) infection is the most frequent infection worldwide and it has been postulated that it predisposes to multiple enteric pathogens and diarrheal diseases. Salmonella infection is common in tropical and under developed communities and is associated with wide range of diseases from gastroenteritis to typhoid fever. This study aimed at detecting the impact of H pylori infection on the incidence of salmonella infections. Read More

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http://dx.doi.org/10.1097/MD.0000000000014335DOI Listing
February 2019
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Helicobacter pylori infection promotes autophagy through Nrf2-mediated heme oxygenase upregulation in human gastric cancer cells.

Biochem Pharmacol 2019 Feb 4. Epub 2019 Feb 4.

Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul 08826, South Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Sciences and Technology, Seoul National University, Seoul 08826, South Korea; Cancer Research Institute, Seoul National University, Seoul 03080, South Korea. Electronic address:

It has been reported that Helicobacter pylori (H. pylori) infection is one of the primary causes of gastritis and peptic ulcer diseases. More than 50% of the world's population is supposed to be infected by this bacterium. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.02.003DOI Listing
February 2019
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Phyto anti-biofilm elicitors as potential inhibitors of .

3 Biotech 2019 Feb 25;9(2):53. Epub 2019 Jan 25.

Department of Water and Health Faculty of Life Sciences, JSS Academy of Higher Education & Research, Sri Shivarathreeshwara Nagara, Mysore, Karnataka 570 015 India.

() infection is a global public health concern. Due to its high adaptability in various adverse environments (temperature, pH, adhesion, phenotypic forms), targeting the bacterium is quite challenging. Moreover, due to its high persistence, decreased patience compliance and emerging antibiotic resistance, researchers have been forced to search for novel candidates with lesser or no side effects. Read More

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http://dx.doi.org/10.1007/s13205-019-1582-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349266PMC
February 2019
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Magnitude of Helicobacter pylori and associated risk factors among symptomatic patients attending at Jasmin internal medicine and pediatrics specialized private clinic in Addis Ababa city, Ethiopia.

BMC Infect Dis 2019 Feb 6;19(1):118. Epub 2019 Feb 6.

Department of medical laboratory Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: More than 50% of the people are infected worldwide with H. pylori which causes significant public health morbidity and mortality. The distribution is quite different from country to country. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3753-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364427PMC
February 2019
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Comparative analysis of glutathione transferase genetic polymorphism, Helicobacter pylori and Epstein-Barr virus between the tumor area and the proximal and distal resection margins of gastric cancer.

Rev Col Bras Cir 2019 Jan 31;46(1):e2068. Epub 2019 Jan 31.

Universidade Federal do Rio de Janeiro, Departamento de Patologia, Rio de Janeiro, RJ, Brasil.

Objective: to compare the polymorphism of the Glutathione S-transferase theta 1 (GSTT1) and Glutathione S-transferase mu 1 (GSTM1) genes from the tumor area with the proximal and distal margins of stomach specimens resected from patients with gastric cancer, and to investigate the presence of Epstein-Barr virus (EBV) DNA and Helicobacter pylori.

Methods: we prospectively collected tissue specimens from the tumor area and from the proximal and distal resection margins of the stomachs of ten patients with gastric adenocarcinoma who underwent gastrectomy with D2 lymphadenectomy, and submitted these specimens to DNA extraction. We compared the tumor area with the proximal and distal margins of the resected stomachs for polymorphism of GSTT1 and GSTM1 genes and investigated the presence of EBV-DNA and H. Read More

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http://dx.doi.org/10.1590/0100-6991e-20192068DOI Listing
January 2019
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The evaluation of nasal mucociliary clearance in patients with Helicobacter pylori infection.

J Laryngol Otol 2019 Feb 6:1-4. Epub 2019 Feb 6.

Department of Otorhinolaryngology,Kanuni Sultan Süleyman Training and Research Hospital,Istanbul,Turkey.

Objective: This study aimed to examine nasal mucociliary clearance time in patients with Helicobacter pylori infection.

Methods: Fifty patients who were newly diagnosed with H pylori infection using gastric biopsy in the gastroenterology out-patient clinic, and 50 age- and gender-matched healthy adults who were admitted to the otorhinolaryngology out-patient clinic, were included in this study. After an otorhinolaryngological examination (anterior rhinoscopy and nasal endoscopic examination), the nasal mucociliary clearance time of each subject was calculated using the saccharine test. Read More

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http://dx.doi.org/10.1017/S0022215119000136DOI Listing
February 2019

Peptic Ulcer Disease: A Brief Review of Conventional Therapy and Herbal Treatment Options.

J Clin Med 2019 Feb 3;8(2). Epub 2019 Feb 3.

Department of Pharmacology and Biochemistry, Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia.

Peptic ulcer is a chronic disease affecting up to 10% of the world's population. The formation of peptic ulcers depends on the presence of gastric juice pH and the decrease in mucosal defenses. Non-steroidal anti-inflammatory drugs (NSAIDs) and infection are the two major factors disrupting the mucosal resistance to injury. Read More

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http://dx.doi.org/10.3390/jcm8020179DOI Listing
February 2019
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Gastric infection perturbs human oral microbiota.

PeerJ 2019 28;7:e6336. Epub 2019 Jan 28.

The Marshall Centre for Infectious Diseases Research and Training, University of Western Australia, Crawley, Western Australia, Australia.

Background: We investigated the effects of gastric infection on the daytime and overnight human oral microbiota.

Methods: Twenty four volunteers were recruited. Ten tested positive for infection by the Carbon-14 Urea Breath Test, and the rest were negative. Read More

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http://dx.doi.org/10.7717/peerj.6336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354663PMC
January 2019