44,324 results match your criteria Helicobacter Pylori Infection


Chromatographic Analyses, In Vitro Biological Activities, and Cytotoxicity of Cannabis sativa L. Essential Oil: A Multidisciplinary Study.

Molecules 2018 Dec 10;23(12). Epub 2018 Dec 10.

Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.

Due to renewed interest in the cultivation and production of Italian L., we proposed a multi-methodological approach to explore chemically and biologically both the essential oil and the aromatic water of this plant. We reported the chemical composition in terms of cannabinoid content, volatile component, phenolic and flavonoid pattern, and color characteristics. Read More

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December 2018

Association between Helicobacter pylori infection and Sjögren syndrome: A meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13528

First Clinical Medical College of Nanjing Medical University.

Background: Helicobacter pylori has been proved as a risk factor of many diseases. There are some researches trying to find connection between H. pylori and Sjögren syndrome (SS). Read More

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December 2018

Crystal structures of HpSoj-DNA complexes and the nucleoid-adaptor complex formation in chromosome segregation.

Nucleic Acids Res 2018 Dec 14. Epub 2018 Dec 14.

Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 300, Taiwan.

ParABS, an important DNA partitioning process in chromosome segregation, includes ParA (an ATPase), ParB (a parS binding protein) and parS (a centromere-like DNA). The homologous proteins of ParA and ParB in Helicobacter pylori are HpSoj and HpSpo0J, respectively. We analyzed the ATPase activity of HpSoj and found that it is enhanced by both DNA and HpSpo0J. Read More

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December 2018

Genetic analysis of a case of Helicobacter pylori-uninfected intramucosal gastric cancer in a family with hereditary diffuse gastric cancer.

Gastric Cancer 2018 Dec 12. Epub 2018 Dec 12.

Kansai Electric Power Hospital, Osaka, Japan.

Germline mutations in CDH1, encoding E-cadherin, are known to be the causative mechanism of hereditary diffuse gastric cancer (HDGC). We encountered two cases of gastric cancer in a Japanese family with HDGC. A 28-year-old man (Case 1) died of advanced gastric cancer. Read More

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December 2018

Effect of 25-hydroxyvitamin D on Helicobacter pylori eradication in patients with type 2 diabetes.

Wien Klin Wochenschr 2018 Dec 12. Epub 2018 Dec 12.

Department of Endocrinology, Anhui Provincial Hospital, 2300000, Hefei, Anhui Province, China.

Background: Various studies have reported a lower Helicobacter pylori eradication rate and a more frequent reinfection rate in type 2 diabetes mellitus (T2DM). Vitamin D has anti-inflammatory and immunoregulatory activity and the role of the vitamin D receptor (VDR) in the antimicrobial activity against H. pylori has been reported. Read More

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December 2018

Helicobacter pylori prevalence and risk factors among children with celiac disease.

Turk J Gastroenterol 2018 Dec 12. Epub 2018 Dec 12.

Institute of Gastroenterology and Hepatology, Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania.

Background/aims: The relationship between Helicobacter pylori and celiac disease (CD) remains controversial. The aim of this study was to assess the prevalence and risk factors for H. pylori infection among children diagnosed with CD. Read More

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December 2018

Tissue transglutaminase activity in human gastric mucosa according to Helicobacter pylori infection.

Exp Biol Med (Maywood) 2018 Dec 12:1535370218819423. Epub 2018 Dec 12.

3 Department of Medicine, University of Padova, Padova 35121, Italy.

Impact Statement: Tissue transglutaminase (t-TG) is unique among TG enzymes because of its additional role in several physiological and pathological activities, including inflammation, fibrosis, and wound healing. The presence of t-TG has previously been described in the intestine of human and animal models, yet studies on t-TG activity in human gastric mucosa are missing. Helicobacter pylori infection is the major cause of gastritis and peptic ulcers. Read More

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December 2018

Lack of Association between IL-6 Polymorphisms and Haplotypes with Gastric Cancer.

J Cell Biochem 2018 Dec 7. Epub 2018 Dec 7.

Universidade do Sagrado Coração (USC), Bauru, São Paulo, Brazil.

The process of combating neoplasms and mononuclear cells, and during H. pylori infection, several pro-inflammatory and anti-inflammatory cytokines are synthesized. In view of the involvement of the IL-6 law and the presence of H. Read More

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December 2018

Correlation Analysis between Infection Status and Tumor Clinical Pathology as Well as Prognosis of Gastric Cancer Patients.

Iran J Public Health 2018 Oct;47(10):1529-1536

Clinical Laboratory, Pingdu People's Hospital, Pingdu 266700, China.

Background: We aimed to investigate the correlation between infection and the development and prognosis of gastric cancer.

Methods: Retrospective analysis was used to collect 120 paraffin-embedded specimens and 42 paracancerous specimens of gastric cancer patients archived in Department of Pathology, Weihaiwei People's Hospital from 2010-2012. All patients with gastric cancer were followed for 5 years. Read More

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October 2018

Factors Associated with Recurrent Ulcers in Patients with Gastric Surgery after More Than 15 Years: A Cross-Sectional Single-Center Study.

Gastroenterol Res Pract 2018 4;2018:8319481. Epub 2018 Nov 4.

Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy "Iuliu Hațieganu", Louis Pasteur St., No. 6, 400349 Cluj-Napoca, Romania.

Aim: We aimed to establish the independent predictive factors (from infection, biliary reflux, histologic features of the gastric mucosa, drugs, comorbidities, and social habits) for gastric stump ulcer occurrence more than 15 years after surgery.

Methods: 76 patients with previous gastric surgery were included: 21 patients with gastric ulcer (marginal ulcer or ulcer of the rest of the gastric remnant-study group) and 55 controls (nonulcer group).

Results: infection tended to be higher in the control group than in the ulcer group (14. Read More

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November 2018

Unraveling the Novel Protective Effect of Patchouli Alcohol Against -Induced Gastritis: Insights Into the Molecular Mechanism and .

Front Pharmacol 2018 22;9:1347. Epub 2018 Nov 22.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.

Patchouli alcohol (PA), a natural tricyclic sesquiterpene extracted from (Blanco) Benth. (Labiatae), has been found to exhibit anti- and anti-inflammatory properties. In this study, we investigated the protective effect of PA against induced gastritis and , and determined the underlying mechanism. Read More

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November 2018

Gastric Focal Neutrophil Infiltration and Wide Duodenal Gastric Foveolar Metaplasia Are Histologic Discriminative Markers for Crohn's Disease and Behçet's Disease.

Digestion 2018 Dec 12:1-10. Epub 2018 Dec 12.

Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.

Background/aims: Behçet's disease (BD) with intestinal lesions and Crohn's disease (CD) share clinical features. However, no report has compared the 2 diseases with regard to lesions of the upper gastrointestinal tract (UGT). We aimed to evaluate endoscopic and histologic findings of UGT in CD and BD. Read More

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December 2018

HONEY-DERIVED LACTOBACILLUS RHAMNOSUS ALLEVIATES HELICOBACTER PYLORI-INDUCED GASTRO-INTESTINAL INFECTION AND GASTRIC INFLAMMATION IN C57BL/6 MICE: AN IMMUNO-HISTOLOGIC STUDY.

Arq Gastroenterol 2018 Jul-Sep;55(3):279-282

Alborz University of Medical Sciences, Department of Microbiology, Karaj, Iran.

Background: Helicobacter pylori (H. pylori) has been introduced by since 1983 by Marshal and Warren to play the main role in the pathophysiology of gastritis and gastric ulcers. Almost half of the world population1 is infected by H. Read More

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Burden of Infections and Associated Risk Factors among Women of Child Bearing Age in Addis Ababa, Ethiopia.

Int J Chronic Dis 2018 12;2018:5183713. Epub 2018 Nov 12.

Addis Ababa University, College of Health Sciences, Department of Medical Laboratory Sciences, Addis Ababa, Ethiopia.

Background: Early detection and treatment of ( infection in women of child bearing ages may reduce the risk of maternal health disorder. This study was conducted to determine the burden of infections and associated risk factors among women of child bearing ages in Kolfe Keranio Subcity Woreda 9 Health Centers, Addis Ababa, Ethiopia.

Methods: Facility based cross sectional study design was conducted from April to October 2015. Read More

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November 2018

Correlation between Quantitative C-Urea Breath Test and Treatment Success in a Population-Based Cohort.

Gastroenterol Res Pract 2018 13;2018:5439539. Epub 2018 Nov 13.

Division of Gastroenterology, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.

Background: There are continual efforts to identify factors which influence the success of first-line therapy for () infection. The C-urea breath test result (C13-UBT) utilizes urease activity and is a highly accurate diagnostic assay. We aimed to determine whether the magnitude of C13-UBT result is related to treatment success. Read More

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November 2018

Downregulation of miR-146a promotes cell migration in Helicobacter pylori-negative gastric cancer.

J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

microRNAs (miRs) are short noncoding RNAs that post-transcriptionally suppress gene expression. miR-146a acts as an oncogene or a tumor suppressor in various cancers, including gastric cancer, but it is unclear what determines whether miR-146a is oncogenic or tumor suppressive and the molecular mechanisms are still largely unknown. The aim of this study was to investigate the role of miR-146a in gastric cancer, by focusing on its expression in patients who were negative for Helicobacter pylori and its reduced and increased expression effect in vitro. Read More

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December 2018

Influence of colonic dialysis using Gubenxiezhuo on the distribution of gut microflora in uremia rats.

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Nephrology, Minhang Hospital,Fudan University, Shanghai, China.

Objective: This study aimed to explore the underlying function of Gubenxiezhuo dialysis on the distribution of gut microflora uremia.

Methods: A uremia rat model was constructed, and the morphology of renal tissue was determined using the hematoxylin-eosin (H&E) staining. Moreover, the blood samples were collected and the expression of IL-1β, IL-6, and CRP was determined using enzyme-linked immunosorbent assay. Read More

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December 2018

MicroRNA‑146a inhibits the inflammatory responses induced by interleukin‑17A during the infection of Helicobacter pylori.

Mol Med Rep 2018 Dec 5. Epub 2018 Dec 5.

Institute of Cardiovascular Disease, The 960th Hospital of Chinese PLA, Jinan, Shandong 250022, P.R. China.

Helicobacter pylori (H. pylori) infection is the major cause of chronic active gastritis and peptic ulcer disease. Upregulation of IL‑17A is associated with H. Read More

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December 2018

Draft Genome Sequence of Helicobacter cinaedi, Compiled by Direct Whole-Genome Sequencing of a Blood Culture-Positive Isolate in Hong Kong.

Microbiol Resour Announc 2018 Nov 8;7(18). Epub 2018 Nov 8.

Department of Pathology, Hong Kong Sanatorium & Hospital, Hong Kong, China.

Isolation of Helicobacter cinaedi from a positive blood culture requires prolonged and stringent subculture conditions. Direct whole-genome sequencing (WGS) of a positive blood culture may provide timely treatment-associated genetic information. Here, we report a draft genome sequence of H. Read More

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November 2018

Gastric Neuroendocrine Tumor and Duodenal Gastrinoma With Chronic Autoimmune Atrophic Gastritis.

Pancreas 2019 Jan;48(1):131-134

Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York.

Our group observed the first case of synchronous gastric neuroendocrine tumor (NET) and duodenal gastrinoma with autoimmune chronic atrophic gastritis (CAG), in the absence of Helicobacter pylori infection. Demographic, clinical, endoscopic, and pathologic data were abstracted from the electronic medical record at Mount Sinai Hospital from 2013 to 2015. The patient's anonymity was carefully protected, and informed consent was obtained for publication of protected health information. Read More

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January 2019

A novel cysteine carbamoyl-switch is responsible for the inhibition of formamidase, a nitrilase superfamily member.

Arch Biochem Biophys 2018 Dec 5. Epub 2018 Dec 5.

Laboratorio de Estudios Cristalográficos, CSIC-UGR, 18100, Granada, Spain. Electronic address:

Formamidases (EC 3.5.1. Read More

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December 2018

Application of data mining methods to improve screening for the risk of early gastric cancer.

BMC Med Inform Decis Mak 2018 Dec 7;18(Suppl 5):121. Epub 2018 Dec 7.

College of Medical Information Engineering, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.

Background: Although gastric cancer is a malignancy with high morbidity and mortality in China, the survival rate of patients with early gastric cancer (EGC) is high after surgical resection. To strengthen diagnosing and screening is the key to improve the survival and life quality of patients with EGC. This study applied data mining methods to improve screening for the risk of EGC on the basis of noninvasive factors, and displayed important influence factors for the risk of EGC. Read More

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December 2018
1 Read

Is it Necessary to Send the Sleeve Gastrectomy Specimens to Pathology?

Surg Laparosc Endosc Percutan Tech 2018 Dec 4. Epub 2018 Dec 4.

Departments of General Surgery.

Background: Laparoscopic sleeve gastrectomy (LSG) has become more popular among other bariatric procedures. The histopathologic changes in the sleeve gastrectomy specimens have not been widely investigated among the Turkish population.

Objective: The purpose of this study was to delineate these histopathologic findings of the LSG specimens of morbidly obese patients from a single center. Read More

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December 2018
1 Read

Overexpression of IL-11 promotes premalignant gastric epithelial hyperplasia in isolation from germline gp130-JAK-STAT3 driver mutations.

Am J Physiol Gastrointest Liver Physiol 2018 Dec 6. Epub 2018 Dec 6.

Murdoch Childrens Research Institute, Australia.

Expression of the cytokine IL-11 is elevated in human Helicobacter pylori infection and progressively increases with worsening gastric pathology. Additionally, IL-11 is required for tumour development in STAT3 dependent murine models of gastric cancer (GC) and, when administered acutely, causes resolving atrophic gastritis. However, it is unclear whether locally elevated IL-11 ligand expression can, in isolation from oncogenic gp130-JAK-STAT pathway mutations, initiate GC pathogenesis. Read More

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December 2018

Changes in the Distal Esophageal Microbiota in Chinese Patients with Reflux Esophagitis.

J Dig Dis 2018 Dec 5. Epub 2018 Dec 5.

Digestive Department, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Objective: Changes in microbiota structure in the distal esophagus may be associated with the pathogenesis of gastroesophageal reflux disease. The composition of the distal esophageal microbiota between Chinese patients and healthy volunteers was compared through metagenomic high-throughput DNA sequencing and bioinformatic analyses.

Methods: Healthy volunteers (HV) and patients with reflux esophagitis (RE) were enrolled. Read More

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December 2018
7 Reads

Genetic polymorphisms in TLR1, TLR2, TLR4, and TLR10 of Helicobacter pylori-associated gastritis: a prospective cross-sectional study in Thailand.

Eur J Cancer Prev 2019 Jan;28(1):58

School of Surgery, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, Thailand.

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January 2019
1 Read

[Establishment and application of gastric and gastric cancer organoids].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1315-1320

Department of Surgery, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China. Email:

Gastric organoid is the organotypic cultures of gastric stem cells or pluripotent stem cells. Gastric organoid is comprised of all major types of gastric epithelial cells and represent the architecture and function remarkably similar to those of the gastric epithelium, faithfully recapitulating the functional gastric epithelium ex vivo. As ideal basic experimental model, gastric organoid has advantages over animal models and conventional cell model in many aspects. Read More

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November 2018

Role of Acid Suppression in Acid-related Diseases: Proton Pump Inhibitor and Potassium-competitive Acid Blocker.

J Neurogastroenterol Motil 2018 Nov 20. Epub 2018 Nov 20.

Fellowship Training Center and Medical Education Center, Keio University School of Medicine, Tokyo, Japan.

Proton pump inhibitors are commonly utilized for the treatment of gastric acid-related conditions, such as gastroesophageal reflux disease, peptic ulcer disease, and infection, and for the prevention of low-dose aspirin or nonsteroidal anti-inflammatory drug associated peptic ulcers. Vonoprazan is a first-in-class potassium-competitive acid blocker, which has distinct advantages compared to other conventional proton pump inhibitors in terms of the rate and effectiveness at which gastric acid suppression occurs. Due to its strong gastric acid suppression capabilities, vonoprazan serves as an effective drug for the treatment of gastroesophageal reflux disease and infection. Read More

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November 2018
1 Read

FASTBAC-Seq: Functional Analysis of Toxin-Antitoxin Systems in Bacteria by Deep Sequencing.

Methods Enzymol 2018 25;612:67-100. Epub 2018 Sep 25.

ARNA Laboratory, INSERM U1212, CNRS UMR 5320, University of Bordeaux, Bordeaux, France. Electronic address:

As the number of bacterial genomes and transcriptomes increases, so does the number of newly identified toxin-antitoxin (TA) systems. However, their functional characterization remains challenging, often requiring the use of overexpression vectors that can lead to misinterpretations of in vivo results. To fill this gap, we developed a systematic approach called FASTBAC-Seq (Functional AnalysiS of Toxin-Antitoxin Systems in BACteria by Deep Sequencing). Read More

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September 2018

H. pylori infection induced BMAL1 expression and rhythm disorder aggravate gastric inflammation.

EBioMedicine 2018 Nov 27. Epub 2018 Nov 27.

Department of Microbiology, Key Laboratory for Experimental Teratology of the Chinese Ministry of Education, School of Basic Medical Science, Shandong University, Jinan, Shandong 250012, PR China; Key Laboratory of Infection and Immunity of Shandong Province, School of Basic Medical Science, Shandong University, Jinan, Shandong 250012, PR China; Cancer Research Laboratory, Shandong University, Karolinska Institutet collaborative Laboratory, School of Basic Medical Science, Shandong University, Jinan, Shandong 250012, PR China. Electronic address:

Background: Rhythm abnormalities are crucial for diverse diseases. However, their role in disease progression induced by Helicobacter pylori (H. pylori) remains elusive. Read More

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November 2018

Immunohistochemical Analysis of LGR5 and TROY Expression in Gastric Carcinogenesis Demonstrates an Inverse Trend

Iran Biomed J 2018 Dec 3. Epub 2018 Dec 3.

HPGC Research Group, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.

Background: Two of the Wnt signaling pathway target genes; tumor necrosis factor receptor family member (TROY) and leucine-rich G-protein coupled receptor (LGR5), are involved in the generation and maintenance of gastrointestinal epithelium. A negative modulatory role has recently been assigned to TROY, in this pathway. Here, we have examined their simultaneous expression in gastric carcinogenesis. Read More

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December 2018

Detection of intracellular Helicobacter pylori in Candida. SPP from neonate oral swabs.

Rev Assoc Med Bras (1992) 2018 Oct;64(10):928-935

Universidad de Concepción, Víctor Lamas 1290, casilla 160 C, Concepción, Región del Biobío, Chile.

Background: There is evidence of detection of Helicobacter pylori (H. pylori) in the stool of newborns and in the yeast that colonizes the oral cavity of this age group. However, there is a lack of research to confirm it. Read More

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October 2018
3 Reads
0.915 Impact Factor

Intestinal metaplasia at the gastroesophageal junction is associated with gastroesophageal reflux but not with Helicobacter pylori infection.

Scand J Gastroenterol 2018 Dec 5:1-7. Epub 2018 Dec 5.

a Department of Gastroenterology, Skåne University Hospital , Clinical Sciences Lund, Lund University , Lund , Sweden.

Objective: Studies of the etiology of intestinal metaplasia (IM) at a normal appearing gastroesophageal junction (GEJ) are conflicting as associations with both H. Pylori (HP) infection and gastroesophageal reflux has been reported. The aim of this study was to investigate whether IM at the GEJ is associated with gastroesophageal reflux or HP infection. Read More

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December 2018
1 Read

Clinical features of Helicobacter pylori antibody-positive junior high school students in Nagano Prefecture, Japan.

Helicobacter 2018 Dec 4:e12559. Epub 2018 Dec 4.

Department of Public Health, Aichi Medical University School of Medicine, Aichi, Japan.

Background: Previously, we conducted an epidemiological study screening for Helicobacter pylori antibody positivity among Japanese junior high school students. In this study, we updated the epidemiological data and assessed the clinical features of H pylori antibody-positive junior high school students.

Materials And Methods: We assessed H pylori antibody-positive subjects who were identified between 2012 and 2015 at four junior high schools in Nagano Prefecture, Japan. Read More

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December 2018
1 Read

Isolation of from Gastric Biopsy of Dyspeptic Patients in Ghana and Preliminary Assessment of the Effect of Extract on Its Growth.

J Trop Med 2018 31;2018:8071081. Epub 2018 Oct 31.

Department of Molecular Biology and Biotechnology, School of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, Ghana.

() is a gram-negative bacterium that colonizes the human stomach. Infection with this microaerophilic bacterium causes gastric and duodenal ulcer. This study sought to isolate , from gastric biopsy samples of dyspeptic patients in Ghana using a 2,3,5-triphenyltetrazolium chloride (TTC) dye incorporated medium method. Read More

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October 2018
1 Read

Association Between ABO Blood Groups and Helicobacter pylori Infection: A Meta-Analysis.

Sci Rep 2018 Dec 4;8(1):17604. Epub 2018 Dec 4.

Department of Biology, Colgate University, 13 Oak Dr, Hamilton, 13346, NY, USA.

There is no consensus among the existing literature on the relationship between ABO blood groups and risk of Helicobacter pylori infection. However, histo-blood group carbohydrates are proposed to influence the risk of acquiring this pathogen via effects on adhesion to the gastric mucosa. The objective of this meta-analysis was to evaluate the association between ABO blood groups and H. Read More

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December 2018
1 Read

Sero-prevalence of Helicobacter pylori CagA immunoglobulin G antibody, serum pepsinogens and haemoglobin levels in adults.

Sci Rep 2018 Dec 4;8(1):17616. Epub 2018 Dec 4.

Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel.

Associations observed of Helicobacter pylori infection with haemoglobin levels are inconsistent. We examined associations of H. pylori sero-prevalence and serum pepsinogens (PGs), as non-invasive markers of atrophic gastritis, with haemoglobin levels. Read More

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December 2018
2 Reads

Combined Gastric and Colorectal Cancer Screening-A New Strategy.

Int J Mol Sci 2018 Dec 3;19(12). Epub 2018 Dec 3.

Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.

Background: Our aim was to evaluate the feasibility of a serological assessment of gastric cancer risk in patients undergoing colonoscopy in countries with low-to-moderate incidence rates.

Methods: Serum samples were prospectively collected from 453 patients (>50 years old) undergoing colonoscopies. Of these, 279 (61. Read More

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December 2018
2 Reads

Helicobacter pylori Infection-Induced Hepatoma-Derived Growth Factor Regulates the Differentiation of Human Mesenchymal Stem Cells to Myofibroblast-Like Cells.

Cancers (Basel) 2018 Nov 30;10(12). Epub 2018 Nov 30.

Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, 100 Tz-You 1st road, Kaohsiung 807, Taiwan.

Hepatoma-derived growth factor (HDGF) plays a critical role in tumor cell proliferation, anti-apoptosis, VEGF expression, lymph node metastasis and poor prognosis in human gastric cancer. Gastric cancer, as one of the most prevalent cancers worldwide, is the second leading cause of cancer-related mortality in the world for the prognosis of gastric cancer is generally poor, especially in patients with advanced stage. () infection causes the chronic inflammation of stomach as well as the development of gastric cancer, with a three to six-fold increased risk of gastric cancer. Read More

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November 2018

Response to Editorial.

Helicobacter 2018 Dec 3:e12558. Epub 2018 Dec 3.

Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging Zoonotic and Infectious Diseases, Centers for Disease Control and Prevention (CDC), Anchorage, Alaska.

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December 2018

Interferon-γ directly induces gastric epithelial cell death and is required for progression to metaplasia.

J Pathol 2018 Dec 3. Epub 2018 Dec 3.

Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA.

Chronic inflammation of the gastric mucosa, often caused by autoimmune gastritis and/or infection with Helicobacter pylori, can lead to atrophy of acid-secreting parietal cells with metaplasia of remaining cells. The histological pattern marks a critical step in the progression from chronic gastritis to gastric cancer, yet underlying mechanism(s) of inflammation-induced cell death of gastric epithelial cells are poorly understood. We investigated direct effects of a type 1 cytokine associated with autoimmunity and infection, interferon-γ (IFN-γ), on gastric epithelial cells. Read More

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December 2018
2 Reads

Multi-omics and temporal dynamics profiling reveal disruption of central metabolism in on bismuth treatment.

Chem Sci 2018 Oct 25;9(38):7488-7497. Epub 2018 Jul 25.

School of Chemistry , Sun Yat-sen University , Guangzhou , 510275 , P. R. China . Email:

Integration of multi-omics enables uncovering cellular responses to stimuli or the mechanism of action of a drug at a system level. Bismuth drugs have long been used for the treatment of infection and their antimicrobial activity was attributed to dysfunction of multiple proteins based on previous proteome-wide studies. Herein, we investigated the response of to a bismuth drug at transcriptome and metabolome levels. Read More

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October 2018
1 Read

Role of a stem-loop structure in transcript stability.

Infect Immun 2018 Dec 3. Epub 2018 Dec 3.

Department of Medicine, Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN

CagA is a secreted effector protein that contributes to gastric carcinogenesis. Previous studies showed that there is variation among strains in steady-state levels of CagA, and that a strain-specific motif downstream of the transcriptional start site (+59 motif) was associated with both high levels of CagA and premalignant gastric histology. The 5' untranslated region contains a predicted stem-loop-forming structure adjacent to the +59 motif. Read More

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December 2018
2 Reads

Correlation between expression of MMP-9 and MMP-3 in Helicobacter pylori infected patients with different gastroduodenal diseases.

Arab J Gastroenterol 2018 Nov 30. Epub 2018 Nov 30.

Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran. Electronic address:

Background And Study Aims: Helicobacter pylori (H. pylori) has been implicated in the pathogenesis of most important gastro-duodenal diseases, such as gastritis, peptic ulcer disease (PUD) and gastric cancer. H. Read More

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November 2018
1 Read

Gastroparesis and Functional Dyspepsia: A Blurring Distinction of Pathophysiology and Treatment.

J Neurogastroenterol Motil 2018 Dec 3. Epub 2018 Dec 3.

Gastrointestinal Unit, Center of Neuroenteric Health, Massachusetts General Hospital, Harvard Medical School, Boston, USA.

Gastroparesis and functional dyspepsia are 2 of the most common gastric neuromuscular disorders. These disorders are usually confused, having both similarities and differences. The pathophysiology of these disorders involves abnormal gastric motility, visceral hypersensitivity, mucosal inflammation, and various cellular changes. Read More

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December 2018
9 Reads

Utilization Rate of Helicobacter pylori Immunohistochemistry Is Not Associated With the Diagnostic Rate of Helicobacter pylori Infection.

Appl Immunohistochem Mol Morphol 2018 Nov 28. Epub 2018 Nov 28.

Department of Pathology and Cell Biology.

Background: Utilization rates of immunohistochemistry (IHC) for the diagnosis of Helicobacter pylori infection may vary by laboratory and/or pathologists. IHC for H. pylori is not performed routinely in our practice. Read More

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November 2018
1 Read

Recent trends in the prevalence of Helicobacter Pylori in symptomatic children: A 12-year retrospective study in a tertiary centre.

J Pediatr Surg 2018 Nov 6. Epub 2018 Nov 6.

Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China. Electronic address:

Objective: Helicobacter pylori infection is common among Asians. However, evidence in the recent years has demonstrated a decrease in the prevalence of H. pylori infection among children and adults worldwide. Read More

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November 2018
1 Read

The role of integrating conjugative elements in Helicobacter pylori: a review.

J Biomed Sci 2018 Nov 29;25(1):86. Epub 2018 Nov 29.

Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu City, Oita, Japan.

The genome of Helicobacter pylori contains many putative genes, including a genetic region known as the Integrating Conjugative Elements of H. pylori type four secretion system (ICEHptfs). This genetic regions were originally termed as "plasticity zones/regions" due to the great genetic diversity between the original two H. Read More

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November 2018

Helicobacter pylori resistance to current therapies.

Curr Opin Gastroenterol 2019 Jan;35(1):6-13

School of Medicine, Trinity College Dublin, Dublin 2, Ireland.

Purpose Of Review: Helicobacter pylori eradication rates have fallen in recent years, mainly because of the emergence of antibiotic-resistant infections. Indeed the WHO has recently designated clarithromycin-resistant H. pylori infection a high priority for antibiotic resistance research and development. Read More

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January 2019
4 Reads

Helicobacter pylori seroprevalence in Spain: influence of adult and childhood sociodemographic factors.

Eur J Cancer Prev 2018 Nov 26. Epub 2018 Nov 26.

Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP).

Helicobacter pylori (H. pylori) chronic infection causes severe digestive diseases, including gastric cancer, and certain strains entail a higher risk. Risk factors for this infection are still not fully understood. Read More

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November 2018
2 Reads