776 results match your criteria Heavy Chain Disease Gamma


Ferulic acid regulates muscle fiber type formation through the Sirt1/AMPK signaling pathway.

Food Funct 2018 Dec 18. Epub 2018 Dec 18.

Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, P. R. China.

Ferulic acid (FA) is a polyphenolic compound of plant cell walls. Several recent studies demonstrated that polyphenolic compounds could regulate muscle fiber type formation. In this study, we investigated the effect of FA on muscle fiber type formation and also explored its molecular mechanism in mouse C2C12 myotubes. Read More

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http://dx.doi.org/10.1039/c8fo01902aDOI Listing
December 2018

A Unique Human Immunoglobulin Heavy Chain Variable Domain-Only CD33 CAR for the Treatment of Acute Myeloid Leukemia.

Front Oncol 2018 22;8:539. Epub 2018 Nov 22.

Lentigen, A Miltenyi Biotec Company, Gaithersburg, MD, United States.

Acute myeloid leukemia (AML) remains a challenging pediatric and adult disease. Given the elevated expression of the CD33 antigen on leukemic blasts, therapeutic approaches to AML now feature the approved antibody drug conjugate (Mylotarg, GO) and investigational CART cell approaches incorporating CD33-binding domains derived from humanized scFvs. We designed a functional chimeric antigen receptor utilizing a human targeting sequence, derived from a heavy chain variable domain, termed CAR33VH. Read More

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http://dx.doi.org/10.3389/fonc.2018.00539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262782PMC
November 2018
1 Read

Effects of repetitive transcranial magnetic stimulation on ER stress-related genes and glutamate, γ-aminobutyric acid and glycine transporter genes in mouse brain.

Biochem Biophys Rep 2019 Mar 12;17:10-16. Epub 2018 Nov 12.

Clinical Immunology, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

Repetitive transcranial magnetic stimulation (rTMS) is an emerging therapy for the treatment of psychiatric disorders. However, the mechanisms underlying the therapeutic effects of rTMS are still unclear, limiting its optimisation. Lasting effects suggest changes in disease-related genes, so we conducted gene chip and qRT-PCR analyses of genes associated with psychiatric diseases in the mouse brain at various times following 1, 20, 30 or 40 days of rTMS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24055808173017
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http://dx.doi.org/10.1016/j.bbrep.2018.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234257PMC
March 2019
7 Reads

Correlation between chronic venous ulcer exudate proteins and clinical profile: A cross-sectional study.

J Proteomics 2019 Feb 24;192:280-290. Epub 2018 Sep 24.

Graduate Program in Tropical Diseases, Botucatu Medical School (FMB), Sao Paulo State University (UNESP), Botucatu, Sao Paulo, Brazil; Center for the Study of Venoms and Venomous Animals (CEVAP), Sao Paulo State University (UNESP), Botucatu, Sao Paulo, Brazil. Electronic address:

Chronic venous ulcers affect the quality of life of patients around the world. The aims of this study were to identify the proteins expressed in chronic venous ulcer exudates, to categorize them according to their roles and to correlate them with the clinical and epidemiological aspects of the disease. The study population consisted of 37 ulcers from 28 patients, and the inflammatory exudates of these thirty-seven ulcers were subjected to tryptic digestion and mass spectrometry analysis. Read More

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http://dx.doi.org/10.1016/j.jprot.2018.09.009DOI Listing
February 2019
8 Reads

Arginine promotes skeletal muscle fiber type transformation from fast-twitch to slow-twitch via Sirt1/AMPK pathway.

J Nutr Biochem 2018 Nov 1;61:155-162. Epub 2018 Sep 1.

Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China. Electronic address:

This study investigated the effect of arginine on skeletal muscle fiber type transformation in mice and in C2C12 myotubes. Our data showed that dietary supplementation of arginine in mice significantly up-regulated the slow myosin heavy chain (MyHC), troponin I-SS, sirtuin1 (Sirt1) and peroxisome proliferator activated receptor-γ coactivator-1α (PGC-1α) protein expressions, as well as significantly down-regulated the fast MyHC protein expression. In C2C12 myotubes, arginine significantly increased the protein level of slow MyHC and the number of slow MyHC-positive cells, as well as significantly decreased the protein level of fast MyHC and the number of fast MyHC-positive cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09552863183044
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http://dx.doi.org/10.1016/j.jnutbio.2018.08.007DOI Listing
November 2018
13 Reads

Identify Cross Talk Between Circadian Rhythm and Coronary Heart Disease by Multiple Correlation Analysis.

J Comput Biol 2018 Dec 19;25(12):1312-1327. Epub 2018 Sep 19.

2 Department of Nephrology, Fujian Provincial Hospital, Fujian Medical University , Fuzhou, China .

Disorder in circadian rhythm has been revealed as a risk factor for coronary heart disease. Several studies in molecular biology established a gene interaction network using coronary heart susceptibility genes and the circadian rhythm pathway. However, cross talk between genes was mostly discovered in single gene pairs. Read More

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http://dx.doi.org/10.1089/cmb.2017.0254DOI Listing
December 2018
1 Read

Two Cases of -Heavy Chain Disease and a Review of the Literature.

Authors:
I Ramasamy Z Rudzki

Case Rep Hematol 2018 12;2018:4832619. Epub 2018 Aug 12.

Heart of England NHS Trust, Birmingham, UK.

Gamma heavy chain disease (-HCD) is a rare lymphoproliferative disorder characterised by the production of a truncated immunoglobulin heavy chain. Fewer than 200 cases have been reported in the literature. In some cases, -HCD occurs with other lymphoid neoplasms. Read More

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http://dx.doi.org/10.1155/2018/4832619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109557PMC
August 2018
10 Reads

Beyond the TNF-α Inhibitors: New and Emerging Targeted Therapies for Patients with Axial Spondyloarthritis and their Relation to Pathophysiology.

Drugs 2018 Sep;78(14):1397-1418

Department of Medicine, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada.

Axial spondyloarthritis (axSpA) is a complex disease that affects the joints and entheses of axial and peripheral joints, and is associated with inflammation in extra-articular sites such as the gut. Improved knowledge on genetics and immunology has improved treatment options with the availability of treatments targeting tumor necrosis factor-α (TNF-α) and interleukin (IL)-17. However, these agents do not provide clinical benefit for about 40% of patients, and additional therapeutic options are necessary. Read More

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http://dx.doi.org/10.1007/s40265-018-0971-xDOI Listing
September 2018
8 Reads

A novel human cell culture model to study visceral smooth muscle phenotypic modulation in health and disease.

Am J Physiol Cell Physiol 2018 Oct 25;315(4):C598-C607. Epub 2018 Jul 25.

Department of Surgery, Maastricht University , Maastricht , The Netherlands.

Adaptation of the smooth muscle cell (SMC) phenotype is essential for homeostasis and is often involved in pathologies of visceral organs (e.g., uterus, bladder, gastrointestinal tract). Read More

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http://dx.doi.org/10.1152/ajpcell.00167.2017DOI Listing
October 2018
2 Reads

Cutis laxa for diagnosis of γ1-heavy-chain deposition disease: Report of four cases.

J Dermatol 2018 Oct 23;45(10):1211-1215. Epub 2018 Jul 23.

Department of Clinical Immunology, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, INSERM UMRS_1165, Paris Diderot University, Sorbonne Paris Cité, Paris, France.

Heavy-chain deposition disease (HCDD) is characterized by tissue deposits of a truncated monoclonal immunoglobulin heavy-chain (HC) on basement membranes. Diagnosis is usually made on kidney biopsy, showing nodular glomerulosclerosis with HC deposits which can be missed, resulting in delay in diagnosis. We report four γ1-HCDD patients presenting with cutis laxa, hypocomplementemia and hypoalbuminemia. Read More

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http://doi.wiley.com/10.1111/1346-8138.14544
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http://dx.doi.org/10.1111/1346-8138.14544DOI Listing
October 2018
11 Reads

Methotrexate-associated lymphoproliferative disorders with angioimmunoblastic T-cell lymphoma-like features accompanied by gamma-heavy chain disease in a patient with rheumatoid arthritis.

Pathol Int 2018 Jul 10. Epub 2018 Jul 10.

Department of Hematology, Iizuka Hospital, Iizuka, Japan.

Although gamma heavy chain disease (γ-HCD) lesions occasionally morphologically resemble angioimmunoblastic T-cell lymphoma (AITL), no association has been described in detail due to the rarity of the disease. In this report, we present a rare manifestation of methotrexate (MTX)-associated lymphoproliferative disorders (LPDs) with AITL-like features accompanied by γ-HCD in a 75-year-old man with rheumatoid arthritis (RA). A biopsy specimen was evaluated using immunohistochemistry, clonal analyses of immunoglobulin V and T-cell receptor γ gene rearrangements by polymerase chain reaction, and Sanger sequencing for confirmation of the structure of deleted γ-HCD clones. Read More

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http://doi.wiley.com/10.1111/pin.12703
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http://dx.doi.org/10.1111/pin.12703DOI Listing
July 2018
6 Reads

Aberrant expression of LncRNA-MIR31HG regulates cell migration and proliferation by affecting miR-31 and miR-31* in Hirschsprung's disease.

J Cell Biochem 2018 Nov 6;119(10):8195-8203. Epub 2018 Apr 6.

Department of Pediatric Surgery, Children's Hospital of Nanjing Medical University, Nanjing, P.R. China.

Hirschsprung's disease (HSCR) is a birth defect that causes a failure of the enteric nervous system to cover the distal gut during early embryonic development. Evidence shows that long non-coding RNAs (lncRNA) play important roles in HSCR. The MIR31 host gene (MIR31HG), also known as Loc554202, is a long non-coding RNA (lncRNA), which acts as the host gene of (microRNA) miR-31 and miR-31*. Read More

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http://dx.doi.org/10.1002/jcb.26830DOI Listing
November 2018
3 Reads

MD-1, a poly herbal formulation indicated in diabetes mellitus ameliorates glucose uptake and inhibits adipogenesis - an in vitro study.

BMC Complement Altern Med 2018 Apr 2;18(1):113. Epub 2018 Apr 2.

SRU Center for Indian Systems of Medicine - Quality Assurance and Standardization, Central Research Facility, Sri Ramachandra University, Porur, Chennai, India.

Background: Type 2 Diabetes (T2D) is a polygenic disease requiring a multipronged therapeutic approach. In the current scenario, the use of polyherbals is increasing among the diabetics. MD-1, a poly herbal formulation is constituted as a mixture of six popular anti diabetic herbs, used in the management of Diabetes mellitus (DM). Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-018-2177-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879540PMC
April 2018
9 Reads

Expression analysis of immune genes in goldfish (Carassius auratus) infected with the monogenean parasite Gyrodactylus kobayashii.

Fish Shellfish Immunol 2018 Jun 20;77:40-45. Epub 2018 Mar 20.

Key Laboratory of Aquaculture Disease Control, Ministry of Agriculture, State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, Hubei Province, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.

Heavy infection with the ectoparasite Gyrodactylus kobayashii commonly leads to high mortality of ornamental goldfish Carassius auratus. To understand the underlying mechanisms of goldfish against infection of gyrodactylids, transcription responses of immune-related genes including IL-1β2, TNFα1, TNFα2, IFN-γ, TGFβ, MHC II β, TCRβ1 and complement factor C3 were studied by real-time quantitative PCR analysis. Significant increases of expression of inflammatory genes such as IL-1β2, TNFα1, TNFα2 and TGFβ were detected at days 7 and 14 post-infection (pi). Read More

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http://dx.doi.org/10.1016/j.fsi.2018.03.033DOI Listing
June 2018
2 Reads

Gamma heavy-chain disease accompanied with follicular lymphoma: a case report.

Biochem Med (Zagreb) 2018 Feb;28(1):010802

Clinical Laboratory, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Spain.

Heavy chain diseases (HCD) are B-cell lymphoprolipherative disorders characterized by the production of monoclonal heavy chains without associated light chains. Some cases of gamma-HCD (γ-HCD) are concurrent with other lymphoid neoplasm. The monoclonal component is not always detectable by serum electrophoresis, and often an immunofixation procedure is necessary to detect this component. Read More

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http://dx.doi.org/10.11613/BM.2018.010802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806617PMC
February 2018
4 Reads

Heavy-Chain Diseases and Myeloma-Associated Fanconi Syndrome: an Update.

Mediterr J Hematol Infect Dis 2018 1;10(1):e2018011. Epub 2018 Jan 1.

Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine, University of Bari "Aldo Moro" Medical School, Bari, Italy.

The heavy chain diseases (HCDs) are rare B-cell malignancies characterized by the production of a monoclonal immunoglobulin heavy chain without an associated light chain. There are three types of HCD, defined by the class of immunoglobulin heavy chain produced: IgA (α-HCD), IgG (γ-HCD), and IgM (μ-HCD). Alpha-HCD is the most common and usually occurs as intestinal malabsorption in a young adult from a country of the Mediterranean area. Read More

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http://dx.doi.org/10.4084/MJHID.2018.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760076PMC
January 2018
6 Reads

Gamma heavy chain disease evolving during the progression of chronic lymphocytic leukemia.

Clin Chem Lab Med 2018 May;56(6):e154-e156

Institute of Laboratory Diagnostics, Hospital of the Brothers of St. John of God, Graz, Austria.

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http://dx.doi.org/10.1515/cclm-2017-0891DOI Listing
May 2018
3 Reads
2.960 Impact Factor

Clinicopathologic features of adult EBV-associated B-cell lymphoproliferative disease.

Pathol Res Pract 2018 Feb 16;214(2):207-212. Epub 2017 Dec 16.

Leopoldina Krankenhaus Schweinfurt, Dept. of Pathology, Formerly University of Wuerzburg, Germany. Electronic address:

In the present study, 21 cases of adult/late-onset EBV-associated lymphoproliferative disease (AELPD) with an uncertain malignant potential were investigated with regard to their histomorphology, immunophenotype, clonal rearrangement of the heavy chain (IgH) and T-cell receptor (TCR) genes and clinical course. The cases were histomorphologically reevaluated and assigned to one of three morphological groups: mononucleosis-like, Hodgkin-like, or polymorphous. In addition, cases with or without detectable necrosis were investigated for differences in clinical outcome. Read More

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http://dx.doi.org/10.1016/j.prp.2017.11.021DOI Listing
February 2018
6 Reads

A Case of Proliferative Glomerulonephritis with Monoclonal IgG Deposits That Showed Predominantly Membranous Features.

Case Rep Nephrol 2017 25;2017:1027376. Epub 2017 Oct 25.

Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.

In 2004, the novel category of monoclonal IgG deposition disease has been proposed and termed "proliferative glomerulonephritis with monoclonal IgG deposits" (PGNMID). This disease is characterized by membranoproliferative glomerulonephritis and staining for a single light-chain isotype and gamma heavy-chain subclass. A 76-year-old male who had monoclonal gammopathy was referred to our hospital because of proteinuria. Read More

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http://dx.doi.org/10.1155/2017/1027376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676379PMC
October 2017
9 Reads

Reabsorption of iron into acutely damaged rat liver: A role for ferritins.

World J Gastroenterol 2017 Nov;23(41):7347-7358

Faculty of Life Sciences, The University of Manchester, Manchester M13 9PL, United Kingdom.

Aim: To studied iron metabolism in liver, spleen, and serum after acute liver-damage, in relation to surrogate markers for liver-damage and repair.

Methods: Rats received intraperitoneal injection of the hepatotoxin thioacetamide (TAA), and were sacrificed regularly between 1 and 96 h thereafter. Serum levels of transaminases and iron were measured using conventional laboratory assays. Read More

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http://dx.doi.org/10.3748/wjg.v23.i41.7347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685841PMC
November 2017
2 Reads

Fish oil omega-3 polyunsaturated fatty acids attenuate oxidative stress-induced DNA damage in vascular endothelial cells.

PLoS One 2017 9;12(11):e0187934. Epub 2017 Nov 9.

Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.

Objective: Omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), likely prevent cardiovascular disease, however their mechanisms remain unclear. Recently, the role of DNA damage in atherogenesis has been receiving considerable attention. Here, we investigated the effects of EPA and DHA on DNA damage in vascular endothelial cells to clarify their antiatherogenic mechanisms. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187934PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679535PMC
December 2017
4 Reads

Selective intrathecal enrichment of G1m1-positive B cells in multiple sclerosis.

Ann Clin Transl Neurol 2017 10 27;4(10):756-761. Epub 2017 Sep 27.

Department of Immunology and Transfusion Medicine Faculty of Medicine University of Oslo and Oslo University Hospital Rikshospitalet Oslo Norway.

Immunoglobulin gamma (IgG) heavy chain genes are associated with susceptibility to multiple sclerosis (MS) and IgG levels in the cerebrospinal fluid (CSF). However, how these variants are implicated in disease mechanisms remains unknown. Here, we show that proliferating plasmablasts expressing the G1m1 allotype of IgG1 are selectively enriched in CSF of G1m1/G1m3 heterozygous MS patients, whereas plasmablasts expressing either G1m1 or G1m3 are evenly distributed in blood. Read More

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http://dx.doi.org/10.1002/acn3.451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634349PMC
October 2017
4 Reads

Contribution of Extracellular Matrix and Signal Mechanotransduction to Epithelial Cell Damage in Inflammatory Bowel Disease Patients: A Proteomic Study.

Proteomics 2017 Dec 29;17(23-24). Epub 2017 Nov 29.

Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.

This study utilizes 2D-DIGE (difference gel etrophoresis), isotope-coded protein labeling and biochemical assays to characterize protein alteration in ulcerative colitis (UC) and Crohn's disease (CD) in human epithelial cell and mucosal biopsies in inflammatory bowel disease (IBD)-affected patients. The aim of this study is to identify the key molecular signatures involved in epithelial cell structure of IBDs. In non-inflamed UC (QUC) keratins, vimentin, and focal adhesion kinase (7) increased, whereas vinculin and de-tyrosinated α-tubulin decreased; inflammation (IUC) exacerbated molecular changes, being collagen type VI alpha 1 chain (COL6A1), tenascin-C and vimentin increased. Read More

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http://doi.wiley.com/10.1002/pmic.201700164
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http://dx.doi.org/10.1002/pmic.201700164DOI Listing
December 2017
17 Reads

Melatonin protects against the pathological cardiac hypertrophy induced by transverse aortic constriction through activating PGC-1β: In vivo and in vitro studies.

J Pineal Res 2017 Oct 16;63(3). Epub 2017 Aug 16.

Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Melatonin, a circadian molecule secreted by the pineal gland, confers a protective role against cardiac hypertrophy induced by hyperthyroidism, chronic hypoxia, and isoproterenol. However, its role against pressure overload-induced cardiac hypertrophy and the underlying mechanisms remains elusive. In this study, we investigated the pharmacological effects of melatonin on pathological cardiac hypertrophy induced by transverse aortic constriction (TAC). Read More

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http://doi.wiley.com/10.1111/jpi.12433
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http://dx.doi.org/10.1111/jpi.12433DOI Listing
October 2017
30 Reads

Brain injury with systemic inflammation in newborns with congenital heart disease undergoing heart surgery.

Exp Ther Med 2017 Jul 22;14(1):228-238. Epub 2017 May 22.

Division of Pediatric Cardiology, Department of Pediatrics, Cohen Children's Medical Center of New York at Northwell Health, New Hyde Park, NY 11040, USA.

The potential role of systemic inflammation on brain injury in newborns with congenital heart disease (CHD) was assessed by measuring levels of central nervous system (CNS)-derived proteins in serum prior to and following cardiac surgery. A total of 23 newborns (gestational age, 39±1 weeks) with a diagnosis of CHD that required cardiac surgery with cardiopulmonary bypass (CPB) were enrolled in the current study. Serum samples were collected immediately prior to surgery and 2, 24 and 48 h following CPB, and serum levels of phosphorylated neurofilament-heavy subunit (pNF-H), neuron-specific enolase (NSE) and S100B were analyzed. Read More

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http://dx.doi.org/10.3892/etm.2017.4493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488503PMC
July 2017
14 Reads

Restoration of pharyngeal dilator muscle force in dystrophin-deficient (mdx) mice following co-treatment with neutralizing interleukin-6 receptor antibodies and urocortin 2.

Exp Physiol 2017 09 6;102(9):1177-1193. Epub 2017 Aug 6.

Department of Physiology, Trinity Biomedical Sciences Institute, Trinity College Dublin, The University of Dublin, Dublin, Ireland.

New Findings: What is the central question of this study? We previously reported impaired upper airway dilator muscle function in the mdx mouse model of Duchenne muscular dystrophy (DMD). Our aim was to assess the effect of blocking interleukin-6 receptor signalling and stimulating corticotrophin-releasing factor receptor 2 signalling on mdx sternohyoid muscle structure and function. What is the main finding and its importance? The interventional treatment had a positive inotropic effect on sternohyoid muscle force, restoring mechanical work and power to wild-type values, reduced myofibre central nucleation and preserved the myosin heavy chain type IIb fibre complement of mdx sternohyoid muscle. Read More

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http://dx.doi.org/10.1113/EP086232DOI Listing
September 2017
15 Reads

Absence of γ-Chain in Keratinocytes Alters Chemokine Secretion, Resulting in Reduced Immune Cell Recruitment.

J Invest Dermatol 2017 10 17;137(10):2120-2130. Epub 2017 Jun 17.

Institute of Immunity and Transplantation, University College London, London, UK; Department of Immunology, Royal Free Hospital Foundation Trust, London, UK. Electronic address:

Loss-of-function mutations in the common gamma (γc) chain cytokine receptor subunit give rise to severe combined immunodeficiency characterized by lack of T and natural killer cells and infant death from infection. Hematopoietic stem cell transplantation or gene therapy offer a cure, but despite successful replacement of lymphoid immune lineages, a long-term risk of severe cutaneous human papilloma virus infections persists, possibly related to persistent γc-deficiency in other cell types. Here we show that keratinocytes, the only cell type directly infected by human papilloma virus, express functional γc and its co-receptors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X173164
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http://dx.doi.org/10.1016/j.jid.2017.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896775PMC
October 2017
29 Reads

Exercise training in Tgα*44 mice during the progression of chronic heart failure: cardiac vs. peripheral (soleus muscle) impairments to oxidative metabolism.

J Appl Physiol (1985) 2017 Aug 18;123(2):326-336. Epub 2017 May 18.

Department of Molecular Medicine, University of Pavia, Pavia, Italy.

Cardiac function, skeletal (soleus) muscle oxidative metabolism, and the effects of exercise training were evaluated in a transgenic murine model (Tgα*44) of chronic heart failure during the critical period between the occurrence of an impairment of cardiac function and the stage at which overt cardiac failure ensues (i.e., from 10 to 12 mo of age). Read More

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http://dx.doi.org/10.1152/japplphysiol.00342.2017DOI Listing
August 2017
11 Reads

Stachydrine ameliorates isoproterenol-induced cardiac hypertrophy and fibrosis by suppressing inflammation and oxidative stress through inhibiting NF-κB and JAK/STAT signaling pathways in rats.

Int Immunopharmacol 2017 Jul 9;48:102-109. Epub 2017 May 9.

College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China; Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing 210023, China; National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing 210023, China. Electronic address:

Cardiac hypertrophy (CH), as one of the major causes of morbidity and mortality in the world, has become an independent and predictive risk factor for adverse cardiovascular events. However, progress in treatment remains sluggish in recent years. Therefore, compounds derived from non-toxic nature plants are urgently needed. Read More

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http://dx.doi.org/10.1016/j.intimp.2017.05.002DOI Listing
July 2017
31 Reads

The clinicopathologic characteristics of kidney diseases related to monotypic IgA deposits.

Kidney Int 2017 03 6;91(3):720-728. Epub 2017 Jan 6.

Department of Nephrology, CHU Poitiers, Centre de référence maladies rares amylose AL et autres maladies par dépôts d'immunoglobulines monoclonales, Poitiers, France; Department of Immunology, National Center for Scientific Research, Joint Research Unit 7276, University of Limoges, Centre de référence maladies rares amylose AL et autres maladies par dépôts d'immunoglobulines monoclonales, Limoges, France.

Monoclonal gammopathy of renal significance (MGRS) regroups renal disorders caused by a monoclonal immunoglobulin without overt hematological malignancy. MGRS includes tubular disorders, glomerular disorders with organized deposits, and glomerular disorders with non-organized deposits, such as proliferative glomerulonephritis with monoclonal IgG deposits. Since glomerular involvement related to monotypic IgA deposits is poorly described we performed retrospective analysis and defined clinico-biological characteristics, renal pathology, and outcome in 19 referred patients. Read More

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http://dx.doi.org/10.1016/j.kint.2016.10.026DOI Listing
March 2017
54 Reads

High-throughput sequencing in acute lymphoblastic leukemia: Follow-up of minimal residual disease and emergence of new clones.

Leuk Res 2017 02 21;53:1-7. Epub 2016 Nov 21.

Univ. Lille, CHU Lille, Department of Hematology, F-59000 Lille, France. Electronic address:

Minimal residual disease (MRD) is known to be an independent prognostic factor in patients with acute lymphoblastic leukemia (ALL). High-throughput sequencing (HTS) is currently used in routine practice for the diagnosis and follow-up of patients with hematological neoplasms. In this retrospective study, we examined the role of immunoglobulin/T-cell receptor-based MRD in patients with ALL by HTS analysis of immunoglobulin H and/or T-cell receptor gamma chain loci in bone marrow samples from 11 patients with ALL, at diagnosis and during follow-up. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01452126163024
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http://dx.doi.org/10.1016/j.leukres.2016.11.009DOI Listing
February 2017
11 Reads

High frequency of clonal IG and T-cell receptor gene rearrangements in histiocytic and dendritic cell neoplasms.

Oncotarget 2016 Nov;7(48):78355-78362

Department of Pathology, National Cancer Center, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

The 2008 World Health Organization (WHO) diagnostic criteria of histiocytic and dendritic cell neoplasms from hematopoietic and lymphoid tissues no longer required the absence of clonal B-cell/T-cell receptor gene rearrangements. It is true that the clonal B-cell/T-cell receptor gene rearrangements have been identified in rare cases of histiocytic and dendritic cell neoplasms, such as those with or following lymphoma/leukemia or in some sporadic histiocytic/dendritic cell sarcomas, but the clonal features of such group of tumor are still not clear. Here we investigated the clonal status of 33 samples including Langerhans cell histiocytosis (LCH), Langerhans cell sarcoma (LCS), follicular dendritic cell sarcoma (FDCS), interdigitating dendritic cell sarcoma (IDCS) and histiocytic sarcoma (HS). Read More

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http://dx.doi.org/10.18632/oncotarget.13058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346644PMC
November 2016
17 Reads

Unravelling the immunopathological mechanisms of heavy chain deposition disease with implications for clinical management.

Kidney Int 2017 02 20;91(2):423-434. Epub 2016 Oct 20.

Department of Immunology, National Center for Scientific Research, Joint Research Unit 7276, University of Limoges, Centre de référence de l'amylose AL et des autres maladies par dépôts d'immunoglobuline monoclonale, Limoges, France.

Randall-type heavy chain deposition disease (HCDD) is a rare disorder characterized by tissue deposition of a truncated monoclonal immunoglobulin heavy chain lacking the first constant domain. Pathophysiological mechanisms are unclear and management remains to be defined. Here we retrospectively studied 15 patients with biopsy-proven HCDD of whom 14 presented with stage 3 or higher chronic kidney disease, with nephrotic syndrome in 9. Read More

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http://dx.doi.org/10.1016/j.kint.2016.09.004DOI Listing
February 2017
78 Reads

Gender differences in the inflammatory cytokine and chemokine profiles induced by binge ethanol drinking in adolescence.

Addict Biol 2017 Nov 4;22(6):1829-1841. Epub 2016 Oct 4.

Department of Molecular and Cellular Pathology of Alcohol, Príncipe Felipe Research Center, Spain.

Heavy binge drinking in adolescence can cause long-term cognitive and behavioral dysfunctions. Recent experimental evidence indicates the participation of immune system activation in the effects of ethanol in the adolescent brain and suggests gender differences. The present study aims to assess plasma cytokine and chemokine levels in male and female adolescents and young adults during acute alcohol intoxication and to correlate these results with the toll-like receptor 4 (TLR4) response. Read More

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http://dx.doi.org/10.1111/adb.12461DOI Listing
November 2017
12 Reads

Proteomic analysis of cerebrospinal fluid for relapsing-remitting multiple sclerosis and clinically isolated syndrome.

Biomed Rep 2016 Jul 28;5(1):35-40. Epub 2016 Apr 28.

Department of Neurology, Faculty of Medicine and University Hospital Hradec Králové, Charles University in Prague, CZ-500 05 Hradec Králové, Czech Republic.

Early diagnosis and treatment of multiple sclerosis (MS) in the initial stages of the disease can significantly retard its progression. The aim of the present study was to identify changes in the cerebrospinal fluid proteome in patients with relapsing-remitting MS and clinically isolated MS syndrome who are at high risk of developing MS (case group) compared to healthy population (control) in order to identify potential new markers, which could ultimately aid in early diagnosis of MS. The protein concentrations of each of the 11 case and 15 control samples were determined using a bicinchoninic acid assay. Read More

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http://dx.doi.org/10.3892/br.2016.668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906564PMC
July 2016
8 Reads

T cell receptor rearrangements in a patient with γ-heavy chain disease: A case report.

Oncol Lett 2016 Jun 4;11(6):4147-4151. Epub 2016 May 4.

Department of Hematology, Luhe Hospital, Capital Medical University, Beijing 101149, P.R. China.

Heavy chain diseases (HCDs) are rare B cell lymphoplasma cell proliferative disorders that are characterized by the production of incomplete monoclonal immunoglobulin (Ig) heavy chains without the associated light chains. γ-HCD (IgG subtype) is a rare subtype, with ~150 cases reported in the literature to date; however, to the best of our knowledge, no reports of T cell receptor (TCR) gene rearrangement in γ-HCD exist in the literature. The present study reports the case of an 81-year-old man with γ-heavy chain disease associated with TCR gene rearrangement, identified in lymph node biopsy and bone marrow aspirate specimens. Read More

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http://dx.doi.org/10.3892/ol.2016.4515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888291PMC
June 2016
9 Reads

Discovery of a gamma heavy chain disease in a patient followed-up for a lymphoplasma cell proliferative disorder.

Ann Biol Clin (Paris) 2016 Jun;74(3):338-40

Laboratoire de biochimie et de biologie moléculaire, Centre hospitalier régional universitaire Trousseau, Tours, France.

Gamma-heavy chains disease is a rare disease, with very few cases described in the literature. It is characterized by the presence of a monoclonal gamma-heavy chain without associated light chain. Its prevalence and prognosis are unknown. Read More

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http://dx.doi.org/10.1684/abc.2016.1149DOI Listing
June 2016
3 Reads

An unusual case of anaplastic lymphoma kinase-positive large B-cell lymphoma in an elderly patient: A case report and discussion.

Exp Ther Med 2016 May 2;11(5):1799-1802. Epub 2016 Mar 2.

Department of Pathology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China.

We present an unusual case of anaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma, with rapid clinical progression, which occurred in a 90-year-old male patient. The patient presented with numerous enlarged lymph nodes in the neck and mediastinum. Histopathological analysis of a single lymph node detected diffuse large immunoblastic- or plasmablastic-like tumor cells, which were strongly immunoreactive for ALK in a granular cytoplasmic distribution, but negative for the expression of CD20 and CD79a. Read More

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http://dx.doi.org/10.3892/etm.2016.3129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840756PMC
May 2016
17 Reads

Multiple myeloma and multiple plasmacytomas associated with free gamma heavy chain, free kappa light chain and IgGk paraproteins: an unusual triple gammopathy.

Ann Clin Biochem 2016 Nov 28;53(6):706-711. Epub 2016 Sep 28.

3 Department of Pathology, University of Michigan, Ann Arbor, MI, USA.

Multiple myeloma is a malignant plasma cell dyscrasia that is becoming more prevalent in an increasingly ageing population. It is a complex disease with clinical phases ranging from the premalignant monoclonal gammopathy of undetermined significance to asymptomatic (smouldering) myeloma and then symptomatic myeloma; the latter occasionally terminating in the clonal proliferation of plasma cells outside the bone marrow. We present a patient whose clonally evolved disease from monoclonal gammopathy of undetermined significance to multiple myeloma demonstrated the presence of an unusual combination of monoclonal immunoproteins. Read More

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http://dx.doi.org/10.1177/0004563216646594DOI Listing
November 2016
19 Reads

EBV-associated Peripheral T-Cell Lymphoma of Gastrointestinal Tract Presented With Widespread Chronic Inflammation: A Case Report.

Appl Immunohistochem Mol Morphol 2017 01;25(1):e1-e8

Departments of *Pathology, Anatomy and Cell Biology †Medical Oncology, Sydney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA ‡Clarient Pathology Services, Aliso Viejo, CA.

We report a case of Epstein-Barr virus (EBV)-associated T-cell lymphoma of gastrointestinal (GI) tract from a 70-year-old white woman who initially presented with a widespread GI inflammation and gastric obstruction. Initial biopsies of the GI tract showed severe chronic inflammation in the esophagus, stomach, and the small intestine. Celiac disease and inflammatory bowel disease were ruled out. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000327DOI Listing
January 2017
11 Reads

Identification of novel mutations including a double mutation in patients with inherited cardiomyopathy by a targeted sequencing approach using the Ion Torrent PGM system.

Int J Mol Med 2016 Jun 14;37(6):1511-20. Epub 2016 Apr 14.

Faculty of Life Science and Technology, Research Center for Molecular Medicine in Yunnan Province, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China.

Inherited cardiomyopathy is the major cause of sudden cardiac death (SCD) and heart failure (HF). The disease is associated with extensive genetic heterogeneity; pathogenic mutations in cardiac sarcomere protein genes, cytoskeletal protein genes and nuclear envelope protein genes have been linked to its etiology. Early diagnosis is conducive to clinical monitoring and allows for presymptomatic interventions as needed. Read More

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http://dx.doi.org/10.3892/ijmm.2016.2565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867886PMC
June 2016
14 Reads

Tetanus neurotoxin HCC protein commits T cells to IFN-γ producing cells.

Cell Mol Biol (Noisy-le-grand) 2016 Mar 20;62(3):20-4. Epub 2016 Mar 20.

Tabriz University of Medical Sciences Department of Immunology, Faculty of Medicine Tabriz Iran

A protective response against tetanus toxin and toxoid demands efficient specific T cell and B cell responses. Tetanus neurotoxin (TeNT), a 150 kDa polypeptide, is the main cause of tetanus disease. TeNT consists of two structurally distinct chains, a 50 kDa N-terminal light (L) and a 100 kDa C-terminal heavy (H) chain. Read More

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March 2016
1 Read

System-based proteomic and metabonomic analysis of the Df(16)A mouse identifies potential miR-185 targets and molecular pathway alterations.

Mol Psychiatry 2017 03 22;22(3):384-395. Epub 2016 Mar 22.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.

Deletions on chromosome 22q11.2 are a strong genetic risk factor for development of schizophrenia and cognitive dysfunction. We employed shotgun liquid chromatography-mass spectrometry (LC-MS) proteomic and metabonomic profiling approaches on prefrontal cortex (PFC) and hippocampal (HPC) tissue from Df(16)A mice, a model of the 22q11. Read More

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http://dx.doi.org/10.1038/mp.2016.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322275PMC
March 2017
1 Read

Detection of circulating tumor cells using GeneScan analysis for antigen receptor gene rearrangements in canine lymphoma patients.

J Vet Med Sci 2016 Jun 18;78(5):877-81. Epub 2016 Feb 18.

Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

The presence of circulating tumor cells (CTCs) serves as a prognostic marker and indicator of disease relapse, as well as a means of evaluating treatment efficacy in human and canine lymphoma patients. As an extension of our previous study for the construction of clinically useful GeneScan system, we utilized the GeneScan system for detecting CTCs in canine lymphoma patients. Samples from the primary lesion and peripheral blood mononuclear cells (PBMCs) were obtained from 32 dogs with lymphoma at initial diagnosis. Read More

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http://dx.doi.org/10.1292/jvms.15-0433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905848PMC
June 2016
5 Reads

Gamma Heavy Chain Disease with T-cell Large Granular Lymphocytic Leukemia: A Case Report and Review of the Literature.

Intern Med 2016 15;55(4):399-403. Epub 2016 Feb 15.

Hematology Division, National Hospital Organization Disaster Medical Center, Japan.

Gamma heavy chain disease (gHCD) is a rare lymphoproliferative disorder characterized by the production of a truncated immunoglobulin heavy chain. Although some cases of gHCD are concurrent with other lymphoid neoplasms, few have been reported. We herein present the case of a 73-year-old woman with gHCD and T-cell large granular lymphocytic leukemia. Read More

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http://dx.doi.org/10.2169/internalmedicine.55.5042DOI Listing
August 2016
3 Reads

Increased Expression of Phosphorylated Polo-Like Kinase 1 and Histone in Bypass Vein Graft and Coronary Arteries following Angioplasty.

PLoS One 2016 28;11(1):e0147937. Epub 2016 Jan 28.

Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE, United States of America.

Interventional procedures, including percutaneous transluminal coronary angioplasty (PTCA) and coronary artery bypass surgery (CABG) to re-vascularize occluded coronary arteries, injure the vascular wall and cause endothelial denudation and medial vascular smooth muscle cell (VSMCs) metaplasia. Proliferation of the phenotypically altered SMCs is the key event in the pathogenesis of intimal hyperplasia (IH). Several kinases and phosphatases regulate cell cycle in SMC proliferation. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147937PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731576PMC
July 2016
5 Reads

Cortical PGC-1α-Dependent Transcripts Are Reduced in Postmortem Tissue From Patients With Schizophrenia.

Schizophr Bull 2016 07 17;42(4):1009-17. Epub 2015 Dec 17.

Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL;

The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α) has been linked to multiple neurological and psychiatric disorders including schizophrenia, but its involvement in the pathophysiology of these disorders is unclear. Experiments in mice have revealed a set of developmentally-regulated cortical PGC-1α-dependent transcripts involved in calcium buffering (parvalbumin, PV), synchronous neurotransmitter release (synaptotagmin 2, Syt2; complexin 1, Cplx1) and axonal integrity (neurofilamaent heavy chain, Nefh). We measured the mRNA expression of PGC-1α and these transcripts in postmortem cortical tissue from control and schizophrenia patients and found a reduction in PGC-1α-dependent transcripts without a change in PGC-1α. Read More

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http://dx.doi.org/10.1093/schbul/sbv184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903048PMC
July 2016
12 Reads

Absence of nonhematopoietic MHC class II expression protects mice from experimental autoimmune myocarditis.

Eur J Immunol 2016 Mar 22;46(3):656-64. Epub 2015 Dec 22.

Department of Biochemistry, CIIL, University of Lausanne, Epalinges, Switzerland.

Experimental autoimmune myocarditis (EAM) is a CD4(+) T-cell-mediated model of human inflammatory dilated cardiomyopathies. Heart-specific CD4(+) T-cell activation is dependent on autoantigens presented by MHC class II (MHCII) molecules expressed on professional APCs. In this study, we addressed the role of inflammation-induced MHCII expression by cardiac nonhematopoietic cells on EAM development. Read More

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http://dx.doi.org/10.1002/eji.201545945DOI Listing
March 2016
17 Reads

Significance of detecting IgH and TCRγ gene rearrangements in patients with hemopoietic maligancies by real-time quantitative PCR.

Genet Mol Res 2015 Oct 9;14(4):12168-77. Epub 2015 Oct 9.

Department of Hematology, The Second Affiliated Hospital of Kunming Medical University, Kunming, China.

The aim of our study was to investigate the association of IgH and TCRγ gene rearrangements in hematological malignancies with the disease and clinical application. IgH and TCRγ gene rearrangements were determined in 69 paraffin and bone marrow specimens with SYBR Green I fluorescent dye and RQ-PCR method, including 21 paraffin-embedded tissues of the onset cases and 48 bone marrow samples, representing 15 ALL and 25 AML cases. After chemotherapy, 8 cases were NHL; the 10 cases of the negative control group were healthy people. Read More

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http://dx.doi.org/10.4238/2015.October.9.5DOI Listing
October 2015
2 Reads

Suppression of murine autoimmune myocarditis achieved with direct renin inhibition.

J Cardiol 2016 09 21;68(3):253-60. Epub 2015 Oct 21.

Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.

Background: The renin angiotensin system (RAS) plays an important role in the pathogenesis of cardiovascular diseases and inflammation. Myocarditis is an inflammatory disease of the heart, and the role of the RAS in its pathophysiology is unknown. Because the direct renin inhibitor, aliskiren, is thought to block RAS completely, we investigated the cardioprotective effect of aliskiren in mice with experimental autoimmune myocarditis (EAM). Read More

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http://dx.doi.org/10.1016/j.jjcc.2015.09.008DOI Listing
September 2016
3 Reads