804 results match your criteria Heavy Chain Disease Gamma


Heavy Lifting: Nomenclature and Novel Therapy for Gamma Heavy Chain Disease and Other Heavy Chain Disorders.

Clin Lymphoma Myeloma Leuk 2020 Mar 6. Epub 2020 Mar 6.

Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH.

Heavy chain disorders are rare B-cell disorders and include heavy chain disease, heavy chain deposition disease, and heavy chain amyloidosis. These disorders share the pathognomonic finding of a truncated immunoglobulin heavy chain without an associated light chain in the serum or urine in the case of heavy chain disease or in the tissues in the case of heavy chain deposition disease and heavy chain amyloidosis but are clinically distinct entities. The clinical recognition and systematic approaches to these disorders are challenging because of the rarity of the diseases, lack of consensus on treatment approaches, and minimal data with novel therapy. Read More

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http://dx.doi.org/10.1016/j.clml.2020.02.020DOI Listing

Performance of anti-CD19 chimeric antigen receptor T cells in genetically defined classes of chronic lymphocytic leukemia.

J Immunother Cancer 2020 Mar;8(1)

Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic

Background: While achieving prolonged remissions in other B cell-derived malignancies, chimeric antigen receptor (CAR) T cells still underperform when injected into patients with chronic lymphocytic leukemia (CLL). We studied the influence of genetics on CLL response to anti-CD19 CAR T-cell therapy.

Methods: First, we studied 32 primary CLL samples composed of 26 immunoglobulin heavy-chain gene variable ()-unmutated (9 -mutated, 8 -mutated, and 9 without mutations in , , or ) and 6 -mutated samples without mutations in the above-mentioned genes. Read More

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http://dx.doi.org/10.1136/jitc-2019-000471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206910PMC

Antigen-Based Nano-Immunotherapy Controls Parasite Persistence, Inflammatory and Oxidative Stress, and Cardiac Fibrosis, the Hallmarks of Chronic Chagas Cardiomyopathy, in A Mouse Model of Infection.

Vaccines (Basel) 2020 Feb 21;8(1). Epub 2020 Feb 21.

Department of Microbiology and Immunology, The University of Texas Medical Branch (UTMB), Galveston, TX 77555-1070, USA.

Chagas cardiomyopathy is caused by (). We identified two candidate antigens (TcG2 and TcG4) that elicit antibodies and T cell responses in naturally infected diverse hosts. In this study, we cloned and in a nanovector and evaluated whether nano-immunotherapy (referred as nano2/4) offers resistance to chronic Chagas disease. Read More

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http://dx.doi.org/10.3390/vaccines8010096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157635PMC
February 2020

Gamma Heavy Chain Disease - Diagnostic Challenges in an Unusual Case and a Brief Synopsis of the Current Literature.

Clin Lab 2020 Jan;66(1)

Background: Gamma heavy chain disease is a disorder characterized by the production of truncated heavy chains without associated light chains. Clinical manifestations differ greatly. Thus far no standard treatment has been formulated. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2019.190623DOI Listing
January 2020

Identification of gamma heavy chain disease using MALDI-TOF mass spectrometry.

Clin Biochem 2020 Mar 26;77:57-61. Epub 2019 Dec 26.

Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, 327 E. 64th St., New York, NY 10065, USA.

We describe the use of MALDI-TOF mass spectrometry in the analysis of a suspected case of gamma heavy chain disease. The patient had an abnormal serum immunofixation result where a monoclonal gamma heavy chain band was present without a corresponding light chain. Analysis by MALDI-TOF mass spectrometry revealed large peaks in the spectrum following IgG-specific purification. Read More

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http://dx.doi.org/10.1016/j.clinbiochem.2019.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046309PMC

Gamma heavy chain disease (γ-HCD) as iatrogenic immunodeficiency- associated lymphoproliferative disorder: Possible emergent subtype of rheumatoid arthritis-associated γ-HCD.

J Clin Exp Hematop 2019 ;59(4):196-201

Gamma heavy chain disease (γ-HCD) is a rare B-cell neoplasm that produces a truncated immunoglobulin γ-heavy chain lacking the light chain. The clinical features of γ-HCD are heterogeneous, resembling different types of B-cell lymphomas. Although rheumatoid arthritis (RA) is one of the common underlying diseases of γ-HCD, the therapeutic modality for RA has changed greatly in recent years; therefore, γ-HCD as iatrogenic immunodeficiency-associated lymphoproliferative disorder (LPD) should be taken into consideration. Read More

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http://dx.doi.org/10.3960/jslrt.19025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954170PMC
January 2019

Heart non-specific effector CD4 T cells protect from postinflammatory fibrosis and cardiac dysfunction in experimental autoimmune myocarditis.

Basic Res Cardiol 2019 12 20;115(1). Epub 2019 Dec 20.

Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland.

Heart-specific CD4 T cells have been implicated in development and progression of myocarditis in mice and in humans. Here, using mouse models of experimental autoimmune myocarditis (EAM) we investigated the role of heart non-specific CD4 T cells in the progression of the disease. Heart non-specific CD4 T cells were obtained from DO11. Read More

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http://dx.doi.org/10.1007/s00395-019-0766-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925074PMC
December 2019
5.414 Impact Factor

Arginine promotes porcine type I muscle fibres formation through improvement of mitochondrial biogenesis.

Br J Nutr 2020 Mar 29;123(5):499-507. Epub 2019 Nov 29.

Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Chengdu, Sichuan611130, People's Republic of China.

The present study aimed to investigate whether arginine (Arg) promotes porcine type I muscle fibres formation via improving mitochondrial biogenesis. In the in vivo study, a total of sixty Duroc × Landrace × Yorkshire weaning piglets with an average body weight of 6·55 (sd 0·36) kg were randomly divided into four treatments and fed with a basal diet or a basal diet supplemented with 0·5, 1·0 and 1·5 % l-Arg, respectively, in a 4-week trial. Results showed that dietary supplementation of 1·0 % Arg significantly enhanced the activity of succinate dehydrogenase, up-regulated the protein expression of myosin heavy chain I (MyHC I) and increased the mRNA levels of MyHC I, troponin I1, C1 and T1 (Tnni1, Tnnc1 and Tnnt1) in longissimus dorsi muscle compared with the control group. Read More

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http://dx.doi.org/10.1017/S000711451900309XDOI Listing

A dendritic cell-targeted chimeric hepatitis B virus immunotherapeutic vaccine induces both cellular and humoral immune responses .

Hum Vaccin Immunother 2020 Apr 26;16(4):779-792. Epub 2019 Nov 26.

Vaccine and Infectious Disease Organization-International Vaccine Centre (VIDO-InterVac), University of Saskatchewan, Saskatoon, SK, Canada.

Chimigen® HBV Immunotherapeutic Vaccine (C-HBV), a recombinant chimeric fusion protein comprising hepatitis B virus (HBV) S1 and S2 surface antigen fragments, Core antigen and a murine monoclonal antibody heavy chain fragment (Fc), was designed and produced in Sf9 insect cells. C-HBV targets the host immune system through specific receptors present on dendritic cells (DCs) which facilitates antigen internalization, processing, and presentation on MHC class I and II to induce both cellular and humoral immune responses against HBV antigens. T cell responses, previously assessed by antigen presentation assays using human peripheral blood mononuclear cell (PBMC)-derived DCs and T cells from uninfected and HBV chronic-infected donors, demonstrated that C-HBV was highly immunogenic. Read More

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http://dx.doi.org/10.1080/21645515.2019.1689081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227651PMC

HDAC4 Controls Muscle Homeostasis through Deacetylation of Myosin Heavy Chain, PGC-1α, and Hsc70.

Cell Rep 2019 10;29(3):749-763.e12

Novartis Institute for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address:

HDAC4, a class IIa histone deacetylase, is upregulated in skeletal muscle in response to denervation-induced atrophy. When HDAC4 is deleted postnatally, mice are partially protected from denervation. Despite the name "histone" deacetylase, HDAC4 demonstrably deacetylates cytosolic and non-histone nuclear proteins. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.09.023DOI Listing
October 2019
1 Read

Identification of New DR5 Agonistic Nanobodies and Generation of Multivalent Nanobody Constructs for Cancer Treatment.

Int J Mol Sci 2019 Sep 27;20(19). Epub 2019 Sep 27.

Faculty of Biological Sciences, Tarbiat Modares University, Teheran 14115-331, Iran.

Current cancer therapeutics suffer from a lack of specificity in targeting tumor cells and cause severe side effects. Therefore, the design of highly specialized drugs comprising antibody derivatives inducing apoptosis in targeted cancer cells is considered to be a promising strategy. Drugs acting on death receptor 5 (DR5) such as DR5 agonist antibodies replacing "TNF-related apoptosis-inducing ligand" (TRAIL) offer feasible opportunities in this direction. Read More

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http://dx.doi.org/10.3390/ijms20194818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801735PMC
September 2019
1 Read

The Adaptome as Biomarker for Assessing Cancer Immunity and Immunotherapy.

Methods Mol Biol 2020 ;2055:369-397

University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

In terms of diagnosing and treating diseases, our adaptive immune system is the "best doctor." It carries out these tasks with unmatched precision, with the help of both T and B cell receptors, our most diverse set of genes, distinguishing one individual from another. It does this by generating autologous extraordinary diversity in the receptors, ranging from 10 to 10 for each chain of the rearranged receptors. Read More

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http://dx.doi.org/10.1007/978-1-4939-9773-2_17DOI Listing
January 2020
1 Read

Gamma-heavy chain monoclonal gammopathy with undetermined significance (MGUS).

J Clin Exp Hematop 2019 Sep 8;59(3):119-123. Epub 2019 Aug 8.

Gamma-heavy chain disease (γ-HCD) is a rare B-cell tumor producing truncated IgG lacking the light chain. The clinical features of γ-HCD are heterogeneous, similar to lymphoplasmacytic lymphoma, and most patients have generalized and progressive disease. In some γ-HCD patients, autoimmune diseases are associated. Read More

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http://dx.doi.org/10.3960/jslrt.19008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798140PMC
September 2019
6 Reads

Clonality testing as complementary tool in the assessment of different patient groups with canine chronic enteropathy.

Vet Immunol Immunopathol 2019 Aug 10;214:109893. Epub 2019 Jul 10.

Clinic for Internal Medicine, Department of Companion Animals and Horses, University of Veterinary Medicine Vienna, Austria.

Differentiation between canine chronic enteropathy (CCE) and intestinal lymphoma is a diagnostic challenge as histopathology might fail to yield unequivocal results. Detection of clonal rearrangements of the T-cell-receptor gamma (TCRG) chain and IG heavy chain (IGH) V-J genes offer a useful solution. In this retrospective study, histopathology samples of 35 CCE patients and 7 healthy Beagle dogs underwent clonality testing. Read More

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http://dx.doi.org/10.1016/j.vetimm.2019.109893DOI Listing
August 2019
6 Reads

Transcriptomic profile change, immunological response and disease resistance of Oreochromis niloticus fed with conventional and Nano-Zinc oxide dietary supplements.

Fish Shellfish Immunol 2019 Oct 25;93:336-343. Epub 2019 Jul 25.

Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Zagazig University, Egypt. Electronic address:

The present investigation was performed to evaluate the efficiency of Zinc oxide (ZnO) as a fish feed additive in immunomodulation of Oreochromis niloticus. Fish were fed on ZnO nano-particles (nZnO) and conventional (ZnO) in two concentrations (30 and 60 mg/kg diet), in addition to the control fish which was fed on Zn free diet. After 6° days, the highest survival rate was recorded in the nZnO -supplemented group. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.07.067DOI Listing
October 2019
2 Reads

Butyrate promotes slow-twitch myofiber formation and mitochondrial biogenesis in finishing pigs via inducing specific microRNAs and PGC-1α expression1.

J Anim Sci 2019 Jul;97(8):3180-3192

Institute of Animal Nutrition, Sichuan Agricultural University, and Key Laboratory of Animal Disease-Resistance Nutrition, Ministry of Education, Chengdu, People's Republic of China.

The present study aimed to investigate the influence of dietary butyrate supplementation on muscle fiber-type composition and mitochondrial biogenesis of finishing pigs, and the underlying mechanisms. Thirty-two LY (Landrace × Yorkshire) growing pigs with BW of 64.9 ± 5. Read More

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http://dx.doi.org/10.1093/jas/skz187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667260PMC
July 2019
15 Reads

Reduced expression of apolipoprotein E and immunoglobulin heavy constant gamma 1 proteins in Fuchs endothelial corneal dystrophy.

Clin Exp Ophthalmol 2019 Nov 5;47(8):1028-1042. Epub 2019 Jul 5.

Department of Ophthalmology, Flinders University, Adelaide, South Australia, Australia.

Background: Fuchs endothelial corneal dystrophy (FECD) is a progressive and potentially a sight threatening disease, and a common indication for corneal grafting in the elderly. Aberrant thickening of Descemet's membrane, formation of microscopic excrescences (guttae) and gradual loss of corneal endothelial cells are the hallmarks of the disease. The aim of this study was to identify differentially abundant proteins between FECD-affected and unaffected Descemet's membrane. Read More

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http://dx.doi.org/10.1111/ceo.13569DOI Listing
November 2019
11 Reads
1.953 Impact Factor

Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.

Am J Hum Genet 2019 07 6;105(1):198-212. Epub 2019 Jun 6.

Sorbonne Université, Institut National de la Santé et de la Recherche Médicale U933, Hôpital Trousseau, Paris 75012, France; Assistance Publique-Hôpitaux de Paris, Département de Génétique Médicale, Hôpital Trousseau, Paris 75012, France.

Motile cilia and sperm flagella share an evolutionarily conserved axonemal structure. Their structural and/or functional defects are associated with primary ciliary dyskinesia (PCD), a genetic disease characterized by chronic respiratory-tract infections and in which most males are infertile due to asthenozoospermia. Among the well-characterized axonemal protein complexes, the outer dynein arms (ODAs), through ATPase activity of their heavy chains (HCs), play a major role for cilia and flagella beating. Read More

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http://dx.doi.org/10.1016/j.ajhg.2019.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612517PMC
July 2019
13 Reads

γ Heavy chain disease.

Blood 2019 03;133(12):1382

Sheikh Khalifa Medical City.

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http://dx.doi.org/10.1182/blood-2018-11-887133DOI Listing
March 2019
7 Reads

Myricanol rescues dexamethasone-induced muscle dysfunction via a sirtuin 1-dependent mechanism.

J Cachexia Sarcopenia Muscle 2019 04 21;10(2):429-444. Epub 2019 Feb 21.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, China.

Background: Muscle atrophy and weakness are adverse effects of high dose or the sustained usage of glucocorticoids. Loss of mitochondria and degradation of protein are highly correlated with muscle dysfunction. The deacetylase sirtuin 1 (SIRT1) plays a vital role in muscle remodelling. Read More

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http://dx.doi.org/10.1002/jcsm.12393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463464PMC
April 2019
1 Read

CD24 targeting bi-specific antibody that simultaneously stimulates NKG2D enhances the efficacy of cancer immunotherapy.

J Cancer Res Clin Oncol 2019 May 18;145(5):1179-1190. Epub 2019 Feb 18.

Antibody Engineering Laboratory, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, 154#, Tong Jia Xiang 24, Nanjing, 210009, People's Republic of China.

Purpose: Bi-specific antibody (BsAb) is an emerging novel format of antibody. We aimed to develop the natural killer (NK) cell receptor NK group 2, member D (NKG2D)-mediated, immune surveillance system. In this system, the NKG2D ligand MHC class I-related chain A (MICA) was fused with BsAb, which targeted a cluster of differentiation 24 (CD24), a tumor-initiating cell marker that is over-expressed on hepatocellular carcinoma (HCC). Read More

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http://link.springer.com/10.1007/s00432-019-02865-8
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http://dx.doi.org/10.1007/s00432-019-02865-8DOI Listing
May 2019
9 Reads
3.081 Impact Factor

FcγRIIIA-mediated activation of NK cells by IgG heavy chain complexed with MHC class II molecules.

Int Immunol 2019 04;31(5):303-314

Department of Immunochemistry, Research Institute for Microbial Diseases.

Natural killer (NK) cells are a major FcγRIIIA-expressing lymphocyte population that mediate antibody-dependent cellular cytotoxicity. Although NK cells are critical for immunity against viruses and tumors, they are also activated in the joints of patients with rheumatoid arthritis (RA) and may be involved in disease progression. We previously found that human leukocyte antigen (HLA) class II molecules transport misfolded cellular proteins, such as IgG heavy chain (IgGH), to the cell surface via association with their peptide-binding grooves. Read More

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http://dx.doi.org/10.1093/intimm/dxz010DOI Listing
April 2019
7 Reads
2.536 Impact Factor

Discovery and characterization of potent IL-21 neutralizing antibodies via a novel alternating antigen immunization and humanization strategy.

PLoS One 2019 25;14(1):e0211236. Epub 2019 Jan 25.

Department of Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, United States of America.

Interleukin-21 (IL-21), a member of the common cytokine receptor γ chain (γc) family, is secreted by CD4+ T cells and natural killer T cells and induces effector function through interactions with the IL-21 receptor (IL-21R)/γc complex expressed on both immune and non-immune cells. Numerous studies suggest that IL-21 plays a significant role in autoimmune disorders. Therapeutic intervention to disrupt the IL-21/IL-21R/γc interaction and inhibit subsequent downstream signal transduction could offer a treatment paradigm for these diseases. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211236PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347146PMC
October 2019
38 Reads

Differential expression of serum proteins in multiple myeloma.

Exp Ther Med 2019 Jan 23;17(1):649-656. Epub 2018 Nov 23.

Department of Pharmacology, Chonbuk National University Medical School, Jeonju, Jeonbuk 560-182, Republic of Korea.

The exact cause instigating multiple myeloma (MM) has not been fully elucidated, and the disease has a median survival of 6 months without any treatment. To identify potential biomarkers of MM, serum proteins reflecting alteration in their proteomes were analyzed in 6 patients with MM compared with 6 healthy controls using two-dimensional electrophoresis (2-DE) and matrix-assisted laser desorption/ionization time-of flight mass spectrometry. The most notable differentially expressed proteins were validated by immunoblotting and changes in mRNA expression were evaluated by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Read More

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http://www.spandidos-publications.com/10.3892/etm.2018.7010
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http://dx.doi.org/10.3892/etm.2018.7010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307483PMC
January 2019
21 Reads

Ferulic acid regulates muscle fiber type formation through the Sirt1/AMPK signaling pathway.

Food Funct 2019 Jan;10(1):259-265

Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, P. R. China.

Ferulic acid (FA) is a polyphenolic compound of plant cell walls. Several recent studies demonstrated that polyphenolic compounds could regulate muscle fiber type formation. In this study, we investigated the effect of FA on muscle fiber type formation and also explored its molecular mechanism in mouse C2C12 myotubes. Read More

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http://dx.doi.org/10.1039/c8fo01902aDOI Listing
January 2019
3 Reads

A Unique Human Immunoglobulin Heavy Chain Variable Domain-Only CD33 CAR for the Treatment of Acute Myeloid Leukemia.

Front Oncol 2018 22;8:539. Epub 2018 Nov 22.

Lentigen, A Miltenyi Biotec Company, Gaithersburg, MD, United States.

Acute myeloid leukemia (AML) remains a challenging pediatric and adult disease. Given the elevated expression of the CD33 antigen on leukemic blasts, therapeutic approaches to AML now feature the approved antibody drug conjugate (Mylotarg, GO) and investigational CART cell approaches incorporating CD33-binding domains derived from humanized scFvs. We designed a functional chimeric antigen receptor utilizing a human targeting sequence, derived from a heavy chain variable domain, termed CAR33VH. Read More

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http://dx.doi.org/10.3389/fonc.2018.00539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262782PMC
November 2018
17 Reads

An inducible knockout of Dicer in adult mice does not affect endurance exercise-induced muscle adaptation.

Am J Physiol Cell Physiol 2019 02 12;316(2):C285-C292. Epub 2018 Dec 12.

Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo , Tokyo , Japan.

The contractile and metabolic properties of adult skeletal muscle change in response to endurance exercise. The mechanisms of transcriptional regulation in exercise-induced skeletal muscle adaptation, including fiber-type switching and mitochondrial biogenesis, have been investigated intensively, whereas the role of microRNA (miRNA)-mediated posttranscriptional gene regulation is less well understood. We used tamoxifen-inducible Dicer1 knockout (iDicer KO) mice to reduce the global expression of miRNAs in adult skeletal muscle and subjected these mice to 2 wk of voluntary wheel running. Read More

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http://dx.doi.org/10.1152/ajpcell.00278.2018DOI Listing
February 2019
16 Reads

Effects of repetitive transcranial magnetic stimulation on ER stress-related genes and glutamate, γ-aminobutyric acid and glycine transporter genes in mouse brain.

Biochem Biophys Rep 2019 Mar 12;17:10-16. Epub 2018 Nov 12.

Clinical Immunology, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

Repetitive transcranial magnetic stimulation (rTMS) is an emerging therapy for the treatment of psychiatric disorders. However, the mechanisms underlying the therapeutic effects of rTMS are still unclear, limiting its optimisation. Lasting effects suggest changes in disease-related genes, so we conducted gene chip and qRT-PCR analyses of genes associated with psychiatric diseases in the mouse brain at various times following 1, 20, 30 or 40 days of rTMS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24055808173017
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http://dx.doi.org/10.1016/j.bbrep.2018.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234257PMC
March 2019
11 Reads

Correlation between chronic venous ulcer exudate proteins and clinical profile: A cross-sectional study.

J Proteomics 2019 02 24;192:280-290. Epub 2018 Sep 24.

Graduate Program in Tropical Diseases, Botucatu Medical School (FMB), Sao Paulo State University (UNESP), Botucatu, Sao Paulo, Brazil; Center for the Study of Venoms and Venomous Animals (CEVAP), Sao Paulo State University (UNESP), Botucatu, Sao Paulo, Brazil. Electronic address:

Chronic venous ulcers affect the quality of life of patients around the world. The aims of this study were to identify the proteins expressed in chronic venous ulcer exudates, to categorize them according to their roles and to correlate them with the clinical and epidemiological aspects of the disease. The study population consisted of 37 ulcers from 28 patients, and the inflammatory exudates of these thirty-seven ulcers were subjected to tryptic digestion and mass spectrometry analysis. Read More

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http://dx.doi.org/10.1016/j.jprot.2018.09.009DOI Listing
February 2019
43 Reads

Arginine promotes skeletal muscle fiber type transformation from fast-twitch to slow-twitch via Sirt1/AMPK pathway.

J Nutr Biochem 2018 11 1;61:155-162. Epub 2018 Sep 1.

Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China. Electronic address:

This study investigated the effect of arginine on skeletal muscle fiber type transformation in mice and in C2C12 myotubes. Our data showed that dietary supplementation of arginine in mice significantly up-regulated the slow myosin heavy chain (MyHC), troponin I-SS, sirtuin1 (Sirt1) and peroxisome proliferator activated receptor-γ coactivator-1α (PGC-1α) protein expressions, as well as significantly down-regulated the fast MyHC protein expression. In C2C12 myotubes, arginine significantly increased the protein level of slow MyHC and the number of slow MyHC-positive cells, as well as significantly decreased the protein level of fast MyHC and the number of fast MyHC-positive cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09552863183044
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http://dx.doi.org/10.1016/j.jnutbio.2018.08.007DOI Listing
November 2018
18 Reads

Identify Cross Talk Between Circadian Rhythm and Coronary Heart Disease by Multiple Correlation Analysis.

J Comput Biol 2018 12 19;25(12):1312-1327. Epub 2018 Sep 19.

2 Department of Nephrology, Fujian Provincial Hospital, Fujian Medical University , Fuzhou, China .

Disorder in circadian rhythm has been revealed as a risk factor for coronary heart disease. Several studies in molecular biology established a gene interaction network using coronary heart susceptibility genes and the circadian rhythm pathway. However, cross talk between genes was mostly discovered in single gene pairs. Read More

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http://dx.doi.org/10.1089/cmb.2017.0254DOI Listing
December 2018
8 Reads

Two Cases of -Heavy Chain Disease and a Review of the Literature.

Authors:
I Ramasamy Z Rudzki

Case Rep Hematol 2018 12;2018:4832619. Epub 2018 Aug 12.

Heart of England NHS Trust, Birmingham, UK.

Gamma heavy chain disease (-HCD) is a rare lymphoproliferative disorder characterised by the production of a truncated immunoglobulin heavy chain. Fewer than 200 cases have been reported in the literature. In some cases, -HCD occurs with other lymphoid neoplasms. Read More

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http://dx.doi.org/10.1155/2018/4832619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109557PMC
August 2018
26 Reads

Beyond the TNF-α Inhibitors: New and Emerging Targeted Therapies for Patients with Axial Spondyloarthritis and their Relation to Pathophysiology.

Drugs 2018 Sep;78(14):1397-1418

Department of Medicine, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada.

Axial spondyloarthritis (axSpA) is a complex disease that affects the joints and entheses of axial and peripheral joints, and is associated with inflammation in extra-articular sites such as the gut. Improved knowledge on genetics and immunology has improved treatment options with the availability of treatments targeting tumor necrosis factor-α (TNF-α) and interleukin (IL)-17. However, these agents do not provide clinical benefit for about 40% of patients, and additional therapeutic options are necessary. Read More

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http://dx.doi.org/10.1007/s40265-018-0971-xDOI Listing
September 2018
13 Reads

A novel human cell culture model to study visceral smooth muscle phenotypic modulation in health and disease.

Am J Physiol Cell Physiol 2018 10 25;315(4):C598-C607. Epub 2018 Jul 25.

Department of Surgery, Maastricht University , Maastricht , The Netherlands.

Adaptation of the smooth muscle cell (SMC) phenotype is essential for homeostasis and is often involved in pathologies of visceral organs (e.g., uterus, bladder, gastrointestinal tract). Read More

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http://dx.doi.org/10.1152/ajpcell.00167.2017DOI Listing
October 2018
12 Reads

Cutis laxa for diagnosis of γ1-heavy-chain deposition disease: Report of four cases.

J Dermatol 2018 Oct 23;45(10):1211-1215. Epub 2018 Jul 23.

Department of Clinical Immunology, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, INSERM UMRS_1165, Paris Diderot University, Sorbonne Paris Cité, Paris, France.

Heavy-chain deposition disease (HCDD) is characterized by tissue deposits of a truncated monoclonal immunoglobulin heavy-chain (HC) on basement membranes. Diagnosis is usually made on kidney biopsy, showing nodular glomerulosclerosis with HC deposits which can be missed, resulting in delay in diagnosis. We report four γ1-HCDD patients presenting with cutis laxa, hypocomplementemia and hypoalbuminemia. Read More

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http://doi.wiley.com/10.1111/1346-8138.14544
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http://dx.doi.org/10.1111/1346-8138.14544DOI Listing
October 2018
21 Reads

Methotrexate-associated lymphoproliferative disorders with angioimmunoblastic T-cell lymphoma-like features accompanied by gamma-heavy chain disease in a patient with rheumatoid arthritis.

Pathol Int 2018 Jul 10. Epub 2018 Jul 10.

Department of Hematology, Iizuka Hospital, Iizuka, Japan.

Although gamma heavy chain disease (γ-HCD) lesions occasionally morphologically resemble angioimmunoblastic T-cell lymphoma (AITL), no association has been described in detail due to the rarity of the disease. In this report, we present a rare manifestation of methotrexate (MTX)-associated lymphoproliferative disorders (LPDs) with AITL-like features accompanied by γ-HCD in a 75-year-old man with rheumatoid arthritis (RA). A biopsy specimen was evaluated using immunohistochemistry, clonal analyses of immunoglobulin V and T-cell receptor γ gene rearrangements by polymerase chain reaction, and Sanger sequencing for confirmation of the structure of deleted γ-HCD clones. Read More

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http://doi.wiley.com/10.1111/pin.12703
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http://dx.doi.org/10.1111/pin.12703DOI Listing
July 2018
28 Reads

Myeloid peroxisome proliferator-activated receptor gamma deficiency aggravates myocardial infarction in mice.

Atherosclerosis 2018 07 5;274:199-205. Epub 2018 May 5.

Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Ninth People's Hospital, School of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200125, China. Electronic address:

Background And Aims: Agonists of peroxisome proliferator-activated receptor gamma (Pparγ) have been demonstrated to reduce the risk of myocardial infarction (MI) in clinical trials and animal experiments. However, the cellular and molecular mechanisms are not completely understood. We aimed to reveal the functions of myeloid Pparγ in MI and explore the potential mechanisms in this study. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.05.005DOI Listing
July 2018
94 Reads

Aberrant expression of LncRNA-MIR31HG regulates cell migration and proliferation by affecting miR-31 and miR-31* in Hirschsprung's disease.

J Cell Biochem 2018 11 6;119(10):8195-8203. Epub 2018 Apr 6.

Department of Pediatric Surgery, Children's Hospital of Nanjing Medical University, Nanjing, P.R. China.

Hirschsprung's disease (HSCR) is a birth defect that causes a failure of the enteric nervous system to cover the distal gut during early embryonic development. Evidence shows that long non-coding RNAs (lncRNA) play important roles in HSCR. The MIR31 host gene (MIR31HG), also known as Loc554202, is a long non-coding RNA (lncRNA), which acts as the host gene of (microRNA) miR-31 and miR-31*. Read More

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http://dx.doi.org/10.1002/jcb.26830DOI Listing
November 2018
20 Reads

MD-1, a poly herbal formulation indicated in diabetes mellitus ameliorates glucose uptake and inhibits adipogenesis - an in vitro study.

BMC Complement Altern Med 2018 Apr 2;18(1):113. Epub 2018 Apr 2.

SRU Center for Indian Systems of Medicine - Quality Assurance and Standardization, Central Research Facility, Sri Ramachandra University, Porur, Chennai, India.

Background: Type 2 Diabetes (T2D) is a polygenic disease requiring a multipronged therapeutic approach. In the current scenario, the use of polyherbals is increasing among the diabetics. MD-1, a poly herbal formulation is constituted as a mixture of six popular anti diabetic herbs, used in the management of Diabetes mellitus (DM). Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-018-2177-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879540PMC
April 2018
22 Reads

Expression analysis of immune genes in goldfish (Carassius auratus) infected with the monogenean parasite Gyrodactylus kobayashii.

Fish Shellfish Immunol 2018 Jun 20;77:40-45. Epub 2018 Mar 20.

Key Laboratory of Aquaculture Disease Control, Ministry of Agriculture, State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, Hubei Province, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.

Heavy infection with the ectoparasite Gyrodactylus kobayashii commonly leads to high mortality of ornamental goldfish Carassius auratus. To understand the underlying mechanisms of goldfish against infection of gyrodactylids, transcription responses of immune-related genes including IL-1β2, TNFα1, TNFα2, IFN-γ, TGFβ, MHC II β, TCRβ1 and complement factor C3 were studied by real-time quantitative PCR analysis. Significant increases of expression of inflammatory genes such as IL-1β2, TNFα1, TNFα2 and TGFβ were detected at days 7 and 14 post-infection (pi). Read More

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http://dx.doi.org/10.1016/j.fsi.2018.03.033DOI Listing
June 2018
8 Reads

PDGFR-β modulates vascular smooth muscle cell phenotype via IRF-9/SIRT-1/NF-κB pathway in subarachnoid hemorrhage rats.

J Cereb Blood Flow Metab 2019 07 26;39(7):1369-1380. Epub 2018 Feb 26.

1 Department of Physiology and Pharmacology, Loma Linda University, School of Medicine, Loma Linda, CA, USA.

Platelet-derived growth factor receptor-β (PDGFR-β) has been reported to promote phenotypic transformation of vascular smooth muscle cells (VSMCs). The purpose of this study was to investigate the role of the PDGFR-β/IRF9/SIRT-1/NF-κB pathway in VSMC phenotypic transformation after subarachnoid hemorrhage (SAH). SAH was induced using the endovascular perforation model in Sprague-Dawley rats. Read More

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http://journals.sagepub.com/doi/10.1177/0271678X18760954
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http://dx.doi.org/10.1177/0271678X18760954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668513PMC
July 2019
24 Reads

Gamma heavy-chain disease accompanied with follicular lymphoma: a case report.

Biochem Med (Zagreb) 2018 Feb;28(1):010802

Clinical Laboratory, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Spain.

Heavy chain diseases (HCD) are B-cell lymphoprolipherative disorders characterized by the production of monoclonal heavy chains without associated light chains. Some cases of gamma-HCD (γ-HCD) are concurrent with other lymphoid neoplasm. The monoclonal component is not always detectable by serum electrophoresis, and often an immunofixation procedure is necessary to detect this component. Read More

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http://dx.doi.org/10.11613/BM.2018.010802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806617PMC
February 2018
11 Reads

Heavy-Chain Diseases and Myeloma-Associated Fanconi Syndrome: an Update.

Mediterr J Hematol Infect Dis 2018 1;10(1):e2018011. Epub 2018 Jan 1.

Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine, University of Bari "Aldo Moro" Medical School, Bari, Italy.

The heavy chain diseases (HCDs) are rare B-cell malignancies characterized by the production of a monoclonal immunoglobulin heavy chain without an associated light chain. There are three types of HCD, defined by the class of immunoglobulin heavy chain produced: IgA (α-HCD), IgG (γ-HCD), and IgM (μ-HCD). Alpha-HCD is the most common and usually occurs as intestinal malabsorption in a young adult from a country of the Mediterranean area. Read More

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http://dx.doi.org/10.4084/MJHID.2018.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760076PMC
January 2018
18 Reads

Gamma heavy chain disease evolving during the progression of chronic lymphocytic leukemia.

Clin Chem Lab Med 2018 05;56(6):e154-e156

Institute of Laboratory Diagnostics, Hospital of the Brothers of St. John of God, Graz, Austria.

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http://dx.doi.org/10.1515/cclm-2017-0891DOI Listing
May 2018
9 Reads
2.960 Impact Factor

Clinicopathologic features of adult EBV-associated B-cell lymphoproliferative disease.

Pathol Res Pract 2018 Feb 16;214(2):207-212. Epub 2017 Dec 16.

Leopoldina Krankenhaus Schweinfurt, Dept. of Pathology, Formerly University of Wuerzburg, Germany. Electronic address:

In the present study, 21 cases of adult/late-onset EBV-associated lymphoproliferative disease (AELPD) with an uncertain malignant potential were investigated with regard to their histomorphology, immunophenotype, clonal rearrangement of the heavy chain (IgH) and T-cell receptor (TCR) genes and clinical course. The cases were histomorphologically reevaluated and assigned to one of three morphological groups: mononucleosis-like, Hodgkin-like, or polymorphous. In addition, cases with or without detectable necrosis were investigated for differences in clinical outcome. Read More

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http://dx.doi.org/10.1016/j.prp.2017.11.021DOI Listing
February 2018
13 Reads

A Case of Proliferative Glomerulonephritis with Monoclonal IgG Deposits That Showed Predominantly Membranous Features.

Case Rep Nephrol 2017 25;2017:1027376. Epub 2017 Oct 25.

Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.

In 2004, the novel category of monoclonal IgG deposition disease has been proposed and termed "proliferative glomerulonephritis with monoclonal IgG deposits" (PGNMID). This disease is characterized by membranoproliferative glomerulonephritis and staining for a single light-chain isotype and gamma heavy-chain subclass. A 76-year-old male who had monoclonal gammopathy was referred to our hospital because of proteinuria. Read More

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http://dx.doi.org/10.1155/2017/1027376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676379PMC
October 2017
23 Reads

Reabsorption of iron into acutely damaged rat liver: A role for ferritins.

World J Gastroenterol 2017 Nov;23(41):7347-7358

Faculty of Life Sciences, The University of Manchester, Manchester M13 9PL, United Kingdom.

Aim: To studied iron metabolism in liver, spleen, and serum after acute liver-damage, in relation to surrogate markers for liver-damage and repair.

Methods: Rats received intraperitoneal injection of the hepatotoxin thioacetamide (TAA), and were sacrificed regularly between 1 and 96 h thereafter. Serum levels of transaminases and iron were measured using conventional laboratory assays. Read More

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http://dx.doi.org/10.3748/wjg.v23.i41.7347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685841PMC
November 2017
8 Reads

Fish oil omega-3 polyunsaturated fatty acids attenuate oxidative stress-induced DNA damage in vascular endothelial cells.

PLoS One 2017 9;12(11):e0187934. Epub 2017 Nov 9.

Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.

Objective: Omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), likely prevent cardiovascular disease, however their mechanisms remain unclear. Recently, the role of DNA damage in atherogenesis has been receiving considerable attention. Here, we investigated the effects of EPA and DHA on DNA damage in vascular endothelial cells to clarify their antiatherogenic mechanisms. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187934PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679535PMC
December 2017
13 Reads

Selective intrathecal enrichment of G1m1-positive B cells in multiple sclerosis.

Ann Clin Transl Neurol 2017 10 27;4(10):756-761. Epub 2017 Sep 27.

Department of Immunology and Transfusion Medicine Faculty of Medicine University of Oslo and Oslo University Hospital Rikshospitalet Oslo Norway.

Immunoglobulin gamma (IgG) heavy chain genes are associated with susceptibility to multiple sclerosis (MS) and IgG levels in the cerebrospinal fluid (CSF). However, how these variants are implicated in disease mechanisms remains unknown. Here, we show that proliferating plasmablasts expressing the G1m1 allotype of IgG1 are selectively enriched in CSF of G1m1/G1m3 heterozygous MS patients, whereas plasmablasts expressing either G1m1 or G1m3 are evenly distributed in blood. Read More

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http://dx.doi.org/10.1002/acn3.451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634349PMC
October 2017
10 Reads

Contribution of Extracellular Matrix and Signal Mechanotransduction to Epithelial Cell Damage in Inflammatory Bowel Disease Patients: A Proteomic Study.

Proteomics 2017 Dec 29;17(23-24). Epub 2017 Nov 29.

Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.

This study utilizes 2D-DIGE (difference gel etrophoresis), isotope-coded protein labeling and biochemical assays to characterize protein alteration in ulcerative colitis (UC) and Crohn's disease (CD) in human epithelial cell and mucosal biopsies in inflammatory bowel disease (IBD)-affected patients. The aim of this study is to identify the key molecular signatures involved in epithelial cell structure of IBDs. In non-inflamed UC (QUC) keratins, vimentin, and focal adhesion kinase (7) increased, whereas vinculin and de-tyrosinated α-tubulin decreased; inflammation (IUC) exacerbated molecular changes, being collagen type VI alpha 1 chain (COL6A1), tenascin-C and vimentin increased. Read More

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http://doi.wiley.com/10.1002/pmic.201700164
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http://dx.doi.org/10.1002/pmic.201700164DOI Listing
December 2017
36 Reads