4,032 results match your criteria Heatstroke

Update: Heat illness, active component, U.S. Armed Forces, 2020.


MSMR 2021 Apr;28(4):10-15

In 2020, there were 475 incident cases of heat stroke and 1,667 incident cases of heat exhaustion among active component service members. The overall crude incidence rates of heat stroke and heat exhaustion were 0.36 cases and 1. Read More

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Intramuscular hematoma in rhabdomyolysis patients treated with low-molecular-weight heparin: Report of two cases.

World J Clin Cases 2021 Apr;9(12):2838-2844

Department of Critical Care Medicine, Nanping First Hospital Affiliated to Fujian Medical University, Nanping 353000, Fujian Province, China.

Background: Rhabdomyolysis is a serious complication of heat stroke. Unlike that in acute kidney injury, the risk of muscle bleeding in rhabdomyolysis is often ignored and can substantially increase the widespread use of anticoagulants, leading to the formation of intramuscular hematoma.

Case Summary: During the summer, a middle-aged man and an elderly man were diagnosed with heat stroke, rhabdomyolysis, and acute renal impairment. Read More

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Nutritional Considerations to Counteract Gastrointestinal Permeability during Exertional Heat Stress.

J Appl Physiol (1985) 2021 May 6. Epub 2021 May 6.

PepsiCo R&D Life Sciences, Gatorade Sports Science Institute, United Statesgrid.418112.f.

Intestinal barrier integrity and function are compromised during exertional heat stress (EHS) potentially leading to consequences that range from minor gastrointestinal (GI) disturbances to fatal outcomes in exertional heat stroke or septic shock. This mini-review provides a concise discussion of nutritional interventions that may protect against intestinal permeability during EHS and suggests physiological mechanisms responsible for this protection. Although diverse nutritional interventions have been suggested to be protective against EHS-induced GI permeability, the ingestion of certain amino acids, carbohydrates, and fluid per se are potentially effective strategies, whereas evidence for various polyphenols and pre/probiotics is developing. Read More

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Monitoring of the decreased mitochondrial viscosity during heat stroke with a mitochondrial AIE probe.

Anal Bioanal Chem 2021 May 2. Epub 2021 May 2.

Institute of Environmental Science, Shanxi University, Taiyuan, 030006, Shanxi, China.

Heat stroke is a fatal condition which usually results in central nervous system dysfunction, organism damage and even death. The relationship between heat stroke and mitochondria is still relatively unknown due to a lack of suitable tools. Herein, an aggregation-induced emission (AIE) probe CSP, by introducing a pyridinium cation as the mitochondria-targeted group to an AIE active core cyanostilbene skeleton, is highly sensitive to viscosity changes due to the restriction of intramolecular motion (RIM) and inhibition of twisted intramolecular charge transfer (TICT) in high-viscosity systems. Read More

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Compound Climate and Infrastructure Events: How Electrical Grid Failure Alters Heat Wave Risk.

Environ Sci Technol 2021 Apr 30. Epub 2021 Apr 30.

School of Geographical Sciences and Urban Planning, Arizona State University, Tempe, Arizona 85287, United States.

The potential for critical infrastructure failures during extreme weather events is rising. Major electrical grid failure or "blackout" events in the United States, those with a duration of at least 1 h and impacting 50,000 or more utility customers, increased by more than 60% over the most recent 5 year reporting period. When such blackout events coincide in time with heat wave conditions, population exposures to extreme heat both outside and within buildings can reach dangerously high levels as mechanical air conditioning systems become inoperable. Read More

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Ethical dilemmas and validity issues related to the use of new cooling technologies and early recognition of exertional heat illness in sport.

BMJ Open Sport Exerc Med 2021 12;7(2):e001041. Epub 2021 Apr 12.

Centre for Stress and Age Related Disease, University of Brighton, Brighton, UK.

The Tokyo 2020 Olympic Games is expected to be among the hottest Games in modern history, increasing the chances for exertional heat stroke (EHS) incidence, especially in non-acclimatised athletes/workers/spectators. The urgent need to recognise EHS symptoms to protect all attendees' health has considerably accelerated research examining the most effective cooling strategies and the development of wearable cooling technology and real-time temperature monitoring. While these technological advances will aid the early identification of EHS cases, there are several potential ethical considerations for governing bodies and sports organisers. Read More

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Endovascular therapy with or without intravenous thrombolysis in acute stroke with tandem occlusion.

J Neurointerv Surg 2021 Apr 28. Epub 2021 Apr 28.

Department of Diagnostic and Therapeutic Neuroradiology, Université de Lorraine, CHRU-Nancy, Nancy, France

Background: Endovascular therapy (EVT) is effective and safe in patients with tandem occlusion. The benefit of intravenous thrombolysis (IVT) prior to EVT in acute tandem occlusion is debatable.

Objective: To compare EVT alone with EVT plus IVT in patients with acute ischemic stroke due to anterior circulation tandem occlusions. Read More

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Lithium beyond psychiatric indications: the reincarnation of a new old drug.

Neural Regen Res 2021 Dec;16(12):2383-2387

University Medical Center Göttingen, Department of Neurology, Göttingen, Germany.

Lithium has been used in the treatment of bipolar disorders for decades, but the exact mechanisms of action remain elusive to this day. Recent evidence suggests that lithium is critically involved in a variety of signaling pathways affecting apoptosis, inflammation, and neurogenesis, all of which contributing to the complex pathophysiology of various neurological diseases. As a matter of fact, preclinical work reports both acute and long-term neuroprotection in distinct neurological disease models such as Parkinson's disease, traumatic brain injury, Alzheimer's disease, and ischemic stroke. Read More

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December 2021

Using logic regression to characterize extreme heat exposures and their health associations: a time-series study of emergency department visits in Atlanta.

BMC Med Res Methodol 2021 Apr 26;21(1):87. Epub 2021 Apr 26.

Department of Biostatistics and Bioinformatics, Emory University, Atlanta, USA.

Background: Short-term associations between extreme heat events and adverse health outcomes are well-established in epidemiologic studies. However, the use of different exposure definitions across studies has limited our understanding of extreme heat characteristics that are most important for specific health outcomes or subpopulations.

Methods: Logic regression is a statistical learning method for constructing decision trees based on Boolean combinations of binary predictors. Read More

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The winter urban heat island: Impacts on cold-related mortality in a highly urbanized European region for present and future climate.

Environ Int 2021 Apr 23;154:106530. Epub 2021 Apr 23.

Climate Change and Health Group, Centre for Radiation Chemical and Environmental Hazards, Public Health England, Chilton, Oxon OX11 0RQ, UK; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham City Hospital, Hucknall Road, NG51PB Nottingham, UK; Heidelberg Institute for Global Health, University of Heidelberg, Im Neuenheimer Feld 130.3, 69120 Heidelberg, Germany.

Exposure to heat has a range of potential negative impacts on human health; hot weather may exacerbate cardiovascular and respiratory illness or lead to heat stroke and death. Urban populations are at increased risk due to the Urban Heat Island (UHI) effect (higher urban temperatures compared with rural ones). This has led to extensive investigation of the summertime UHI and its effects, whereas far less research focuses on the wintertime UHI. Read More

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Thrombotic complications of superficial endovenous ablation: a contemporary review of thermal and non-thermal techniques.

J Cardiovasc Surg (Torino) 2021 Apr 23. Epub 2021 Apr 23.

Division of Vascular and Endovascular Surgery, University of California San Francisco-Fresno, Fresno, CA, USA -

Endovenous ablation has become the preferred means to treat superficial venous insufficiency. Ablative technologies have evolved to include a variety of both thermal and nonthermal techniques. The reported thrombotic complications of endovenous heat induced thrombosis (EHIT) and deep venous thrombosis (DVT) associated with thermal techniques are low (<2% overall). Read More

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Preventive Effects of on Heat Stroke in Rats by Sustaining Intestinal Barrier Function and Modulating Gut Microbiota.

Front Microbiol 2021 6;12:630841. Epub 2021 Apr 6.

Department of Emergency, Changhai Hospital, Naval Medical University, Shanghai, China.

Heat stroke (HS) models in rats are associated with severe intestinal injury, which is often considered as the key event at the onset of HS. Probiotics can regulate the gut microbiota by inhibiting the colonization of harmful bacteria and promoting the proliferation of beneficial bacteria. Here, we investigated the preventive effects of a probiotic strain (BL, CMCC 63516) on HS rats as well as its effects on intestinal barrier function and gut microbiota. Read More

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Prehospital management of exertional heat stroke at sports competitions: International Olympic Committee Adverse Weather Impact Expert Working Group for the Olympic Games Tokyo 2020.

Br J Sports Med 2021 Apr 22. Epub 2021 Apr 22.

Marubeni Health Promotion Center, Marubeni Corporation, Chuo-ku, Japan.

Objectives: This document aimed to summarise the key components of exertional heat stroke (EHS) prehospital management.

Methods: Members of the International Olympic Committee Adverse Weather Impact Expert Working Group for the Olympic Games Tokyo 2020 summarised the current best practice regarding the EHS prehospital management.

Results: Sports competitions that are scheduled under high environmental heat stress or those that include events with high metabolic demands should implement and adopt policy and procedures for EHS prehospital management. Read More

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Identification of regulated proteins by epigallocatechin gallate treatment in an ischemic cerebral cortex animal model: a proteomics approach.

J Vet Med Sci 2021 Apr 21. Epub 2021 Apr 21.

Department of Anatomy, College of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University.

Ischemic stroke is a fatal disease that has long-term disability. It induces excessive oxidative stress generation and cellular metabolic disorders, result in tissue damage. Epigallocatechin gallate (EGCG) is a naturally derived flavonoid with strong antioxidant property. Read More

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Roundtable on Preseason Heat Safety in Secondary School Athletics: Heat Acclimatization.

J Athl Train 2021 Apr;56(4):352-361

Springville High School, UT.

Objective: To provide best-practice recommendations for developing and implementing heat-acclimatization strategies in secondary school athletics.

Data Sources: An extensive literature review on topics related to heat acclimatization and heat acclimation was conducted by a group of content experts. Using the Delphi method, action-oriented recommendations were developed. Read More

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Impact of the gut microbiota on heat stroke rat mediated by Xuebijing metabolism.

Microb Pathog 2021 Apr 20;155:104861. Epub 2021 Apr 20.

The First Clinical Medical College, Southern Medical University, Guangzhou, China; Department of Critical Care Medicine, General Hospital of Guangzhou Military Command, Guangzhou, China. Electronic address:

The goal of the present study was to evaluate the fecal microbiome and serum metabolites in Xuebijing (XBJ)-injected rats after heat stroke using 16S rRNA gene sequencing and gas chromatography-mass spectrometry (GC-MS) metabolomics. Eighteen rats were divided into the control group (CON), heat stroke group (HS), and XBJ group. The 16S rRNA gene sequencing results revealed that the abundance of Bacteroidetes was overrepresented in the XBJ group compared to the HS group, while Actinobacteria was underrepresented. Read More

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A novel mouse model of heatstroke accounting for ambient temperature and relative humidity.

J Intensive Care 2021 Apr 16;9(1):35. Epub 2021 Apr 16.

Department of Emergency, Critical Care and Disaster Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan.

Background: Heatstroke is associated with exposure to high ambient temperature (AT) and relative humidity (RH), and an increased risk of organ damage or death. Previously proposed animal models of heatstroke disregard the impact of RH. Therefore, we aimed to establish and validate an animal model of heatstroke considering RH. Read More

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Correction to: Establishment and effectiveness evaluation of a scoring system for exertional heat stroke by retrospective analysis.

Mil Med Res 2021 Apr 16;8(1):26. Epub 2021 Apr 16.

Department of Critical Care Medicine, The First Medical Centre, Chinese PLA General Hospital, No. 28, Fuxing Road, Haidian District, Beijing, 100853, China.

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Finite-time performance of a single-ion quantum Otto engine.

Phys Rev E 2021 Mar;103(3-1):032144

Department of Physics, Indian Institute of Technology Ropar, Rupnagar, Punjab 140001, India.

We study how a quantum heat engine based on a single trapped ion performs in finite time. The always-on thermal environment acts like the hot bath, while the motional degree of freedom of the ion plays the role of the effective cold bath. The hot isochoric stroke is implemented via the interaction of the ion with its hot environment, while a projective measurement of the internal state of the ion is performed as an equivalent to the cold isochoric stroke. Read More

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The effect of female sex hormones on Hsp27 phosphorylation and histological changes in prefrontal cortex after tMCAO.

Pathol Res Pract 2021 Mar 24;221:153415. Epub 2021 Mar 24.

Anatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. Electronic address:

Background: Female sex hormones are protective factors against many neurological disorders such as brain ischemia. Heat shock protein like HSP27 is activated after tissue injury. The main purpose of the present study is to determine the effect of a combined estrogen / progesterone cocktail on the morphology of astrocytes, neurons and Hsp27 phosphorylation after cerebral ischemia. Read More

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Evidence-Based Heatstroke Management in the Emergency Department.

West J Emerg Med 2021 Feb 26;22(2):186-195. Epub 2021 Feb 26.

University of Colorado School of Medicine, Department of Emergency Medicine, Aurora, Colorado.

Introduction: Climate change is causing an increase in the frequency and intensity of extreme heat events, which disproportionately impact the health of vulnerable populations. Heatstroke, the most serious heat-related illness, is a medical emergency that causes multiorgan failure and death without intervention. Rapid recognition and aggressive early treatment are essential to reduce morbidity and mortality. Read More

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February 2021

A note on the power per mitochondrion and the number of associated active ATP synthases.

Phys Biol 2021 Apr 14. Epub 2021 Apr 14.

Department of Chemistry and Physics, Mount Saint Vincent University, Halifax, Nova Scotia, B3M 2J6, Halifax, Nova Scotia, B3M 2J6, CANADA.

Recent experiments and thermodynamic arguments suggest that mitochondrial temperatures are higher than those of the cytoplasm. A "hot mitochondrion" calls for a closer examination of the energy balance that endows it with these claimed elevated temperatures. As a first step in this effort, we present here a semi-quantitative bookkeeping whereby, in one stroke, a formula is proposed that yields the rate of heat production in a typical mitochondrion and a formula for estimating the number of active ATP synthase molecules per mitochondrion. Read More

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Clinical Spectrum of Pediatric Heat Illness and Heatstroke in a North American Desert Climate.

Pediatr Emerg Care 2021 Apr 9. Epub 2021 Apr 9.

From the Department of Emergency Medicine, University of Nevada, Las Vegas School of Medicine, Las Vegas, NV.

The spectrum of historical features and clinical presentations of heat illness and heatstroke in the pediatric population has received limited focus in the emergency medicine literature. The majority of published cases involve children trapped in closed spaces and adolescent athletes undergoing high-intensity training regimens in geographical regions with moderately high ambient temperatures and high humidity. There has been less research on the potential impact of extreme temperatures and radiant heat that are the hallmarks of the US southwest region. Read More

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lncRNA C2dat2 facilitates autophagy and apoptosis via the miR-30d-5p/DDIT4/mTOR axis in cerebral ischemia-reperfusion injury.

Aging (Albany NY) 2021 Apr 4;13(8):11315-11335. Epub 2021 Apr 4.

Henan Provincial Engineering Laboratory of Insects Bio-Reactor, Nanyang Normal University, Nanyang 473000, China.

Cerebral ischemia-reperfusion injury (CIRI) is an important pathophysiological process of ischemic stroke associated with various physiological and pathological processes, including autophagy and apoptosis. In this study, we examined the role and mechanism of long noncoding RNA CAMK2D-associated transcript 2 (C2dat2) in regulating CIRI and . C2dat2 up-regulation facilitated neuronal autophagy and apoptosis induced by CIRI. Read More

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Accidental hypothermia: Factors related to a prolonged hospital stay - A nationwide observational study in Japan.

Am J Emerg Med 2021 Mar 29;47:169-175. Epub 2021 Mar 29.

Department of Critical Care and Emergency Medicine, Tokyo Women's Medical University, Japan; Japan Association of Acute Medicine Heatstroke and Hypothermia Surveillance Committee, Tokyo, Japan.

Background: The incidence of accidental hypothermia (AH) is low, and the length of hospital stay in patients with AH remains poorly understood. The present study explored which factors were related to prolonged hospitalization among patients with AH using Japan's nationwide registry data.

Methods: The data from the Hypothermia STUDY 2018, which included patients ≥18 years old with a body temperature ≤ 35 °C, were obtained from a multicenter registry for AH conducted at 89 institutions throughout Japan, collected from December 1, 2018, to February 28, 2019. Read More

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Biallelic hypomorphic mutations in HEATR5B, encoding HEAT repeat-containing protein 5B, in a neurological syndrome with pontocerebellar hypoplasia.

Eur J Hum Genet 2021 Apr 6. Epub 2021 Apr 6.

Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.

HEAT repeats are 37-47 amino acid flexible tandem repeat structural motifs occurring in a wide variety of eukaryotic proteins with diverse functions. Due to their ability to undergo elastic conformational changes, they often serve as scaffolds at sites of protein interactions. Here, we describe four affected children from two families presenting with pontocerebellar hypoplasia manifest clinically with neonatal seizures, severe intellectual disability, and motor delay. Read More

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Multi-system neurological disorder associated with a CRYAB variant.

Neurogenetics 2021 May 3;22(2):117-125. Epub 2021 Apr 3.

Department of Neurology, Genetics, Hadassah Medical Organization and Faculty of Medicine, Hebrew University, Jerusalem, Israel.

We report a multiplex family with extended multisystem neurological phenotype associated with a CRYAB variant. Two affected siblings were evaluated with whole exome sequencing, muscle biopsy, laser microdissection, and mass spectrometry-based proteomic analysis. Both patients and their mother manifested a combination of early-onset cataracts, cardiomyopathy, cerebellar ataxia, optic atrophy, cognitive impairment, and myopathy. Read More

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Evaluation of cytokines and structural proteins to analyze the pathology of febrile central nervous system disease.

Leg Med (Tokyo) 2021 Mar 16;51:101864. Epub 2021 Mar 16.

Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka 545-8585, Japan; Forensic Autopsy Section, Medico-legal Consultation and Postmortem Investigation Support Center, c/o Department of Legal Medicine, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno, Osaka 545-8585, Japan. Electronic address:

This study was designed to examine the pathophysiological differences in interleukin (IL) and structural protein levels between central nervous system (CNS) disorders associated with heat stroke and CNS stimulants. We measured the concentrations of IL-6, IL-8, neuron-specific enolase (NSE), and myelin basic protein (MBP) in blood and cerebrospinal fluid (CSF) from 87 autopsy cases. In addition, to examine changes in each marker, we cultured nerve cells at 40 °C as a heat stroke model and administered 4-aminopyridine and ephedrine in cultured cells as a CNS stimulant model. Read More

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