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    Heart heat separation.
    J Physiol 2017 May 25. Epub 2017 May 25.
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands.
    The human heart requires a considerable amount of energy (10 W at rest to 100 W during exercise) for basal metabolism, activation processes and work to circulate blood (heart rate × stroke volume × arterial blood pressure). This article is protected by copyright. All rights reserved. Read More

    [Preparation and application of cooling bag for heat stroke in wild field].
    Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2017 May;29(5):479-480
    Department of Critical Care Medicine, the 401st Hospital of PLA, Qingdao 266071, Shandong, China (Li HL, Wang HP); Division of Medical Affairs, the 401st Hospital of PLA, Qingdao 266071, Shandong, China (Lu Q, Li LJ). Corresponding author: Li Lujia, Email:
    Objective: Cooling bag for heat stroke in wild field was invented in order to fulfill rapid cooling for heat stroke in field environment. The cooling bag is composed of the hood, the body cover (which is made up of the anterior portion, the linking, and the posterior portion), the fixed straps, the handles. The length is 200 cm, the regulative width is 60-70 cm, the folding volume is 26 cm × 20 cm × 9 cm, and the weight is 1. Read More

    Different Effects of Cold Stimulation on Reflex and Non-Reflex Components of Poststroke Spastic Hypertonia.
    Front Neurol 2017 28;8:169. Epub 2017 Apr 28.
    Department of Physical Medicine and Rehabilitation, McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.
    Objective: To use an established biomechanical approach to quantify reflex and non-reflex responses from spastic-paretic elbow flexors in response to controlled cold and heat stimulation.

    Methods: Thirteen spastic-hemiplegic stroke subjects were tested in the experiment. The spastic elbow joint was stretched into extension for 50° at two speeds (5°/s and 100°/s) in a customized apparatus. Read More

    Sodium tanshinone IIA sulfonate improves inflammation, aortic endothelial cell apoptosis, disseminated intravascular coagulation and multiple organ damage in a rat heat stroke model.
    Mol Med Rep 2017 May 11. Epub 2017 May 11.
    Department of Emergency, Wuhan General Hospital of Guangzhou Military Command, Wuhan, Hubei 430070, P.R. China.
    The aim of the present study was to investigate the effects of sodium tanshinone IIA sulfonate (STS) on inflammatory responses, aortic endothelial cell apoptosis, disseminated intravascular coagulation (DIC) and multiple organ damage in an animal model of classic heat stroke (CHS). The rats in the heat stroke (HS) and STS‑treated heat stroke (STS‑HS) groups were placed into a pre‑warmed animal temperature controller (ATC) at 35˚C. The moment at which the rectal temperature reached 43. Read More

    Suppression of cognitive function in hyperthermia; From the viewpoint of executive and inhibitive cognitive processing.
    Sci Rep 2017 Mar 7;7:43528. Epub 2017 Mar 7.
    Department of Health Sciences, Faculty of Human Life and Environment, Nara Women's University, Nara, Japan.
    Climate change has had a widespread impact on humans and natural systems. Heat stroke is a life-threatening condition in severe environments. The execution or inhibition of decision making is critical for survival in a hot environment. Read More

    Increased cerebral expressions of MMPs, CLDN5, OCLN, ZO1 and AQPs are associated with brain edema following fatal heat stroke.
    Sci Rep 2017 May 10;7(1):1691. Epub 2017 May 10.
    Department of Forensic Pathology, School of Forensic Medicine, Southern Medical University, Guangzhou, China.
    Human brain samples were collected from 46 autopsy cases, including 23 fatal heat stroke cases and 23 age-matched controls. Nine candidate reference genes (PES1, POLR2A, IPO8, HMBS, SDHA, GAPDH, UBC, B2M, ACTB) were evaluated in the cerebral cortex of 10 forensic autopsy cases (5 heat stroke and 5 controls), using the geNorm module in qBase(plus) software. SDHA, POLR2A, IPO8 and HMBS were identified as the most stable reference genes. Read More

    Wearing graduated compression stockings augments cutaneous vasodilation but not sweating during exercise in the heat.
    Physiol Rep 2017 May;5(9)
    Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba City, Japan
    The activation of cutaneous vasodilation and sweating are essential to the regulation of core temperature during exercise in the heat. We assessed the effect of graduated compression induced by wearing stockings on cutaneous vasodilation and sweating during exercise in the heat (30°C). On two separate occasions, nine young males exercised for 45 min or until core temperature reached ~1. Read More

    [Impact of daily mean temperature, cold spells, and heat waves on stroke mortality a multivariable Meta-analysis from 12 counties of Hubei province, China].
    Zhonghua Liu Xing Bing Xue Za Zhi 2017 Apr;38(4):508-513
    Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University, Wuhan 430071, China.
    Objective: To assess the acute effects of daily mean temperature, cold spells, and heat waves on stroke mortality in 12 counties across Hubei province, China. Methods: Data related to daily mortality from stroke and meteorology in 12 counties across Hubei province during 2009-2012, were gathered. Distributed lag nonlinear model (DLNM) was first used, to estimate the county-specific associations between daily mean temperature, cold spells, heat waves and stroke mortality. Read More

    Strenuous exercise triggers a life-threatening response in mice susceptible to malignant hyperthermia.
    FASEB J 2017 May 2. Epub 2017 May 2.
    Center for Research on Ageing and Translational Medicine (CeSI-MeT), Department of Neuroscience, Imaging, and Clinical Sciences (DNICS), University G. d' Annunzio of Chieti, Chieti, Italy;
    In humans, hyperthermic episodes can be triggered by halogenated anesthetics [malignant hyperthermia (MH) susceptibility] and by high temperature [environmental heat stroke (HS)]. Correlation between MH susceptibility and HS is supported by extensive work in mouse models that carry a mutation in ryanodine receptor type-1 (RYR1(Y522S/WT)) and knockout of calsequestrin-1 (CASQ1-null), 2 proteins that control Ca(2+) release in skeletal muscle. As overheating episodes in humans have also been described during exertion, here we subjected RYR1(Y522S/WT) and CASQ1-null mice to an exertional-stress protocol (incremental running on a treadmill at 34°C and 40% humidity). Read More

    The impact of temperature extremes on mortality: a time-series study in Jinan, China.
    BMJ Open 2017 May 2;7(4):e014741. Epub 2017 May 2.
    School of Public Health, University of Sydney, Sydney, Australia.
    Objective: To investigate the relationship between temperature extremes and daily number of deaths in Jinan, a temperate city in northern China.

    Methods: Data ondaily number of deaths and meteorological variables over the period of 2011-2014 were collected. Cold spells or heat waves were defined as ≥3 consecutive days with mean temperature ≤5th percentile or ≥95th percentile, respectively. Read More

    Clinical and Biochemical Characteristics of Exertional Heat Stroke among Paratroopers in Agra, India.
    J Assoc Physicians India 2017 Feb;65(2):57-61
    Consultant Pathologist, Department of Internal Medicine, Military Hospital, Agra Cantt., Uttar Pradesh.
    Objective: The purpose of this study was to assess the clinical profile, biochemical parameters and outcome in a series of 78 patients of heat stroke admitted and treated in a military hospital in India.

    Methods: This was a prospective study in a military hospital. A total of 78 patients of exertional heat stroke admitted and treated over more than 2 years are reported. Read More

    Short-term heat stress alters redox balance in porcine skeletal muscle.
    Physiol Rep 2017 Apr 28;5(8). Epub 2017 Apr 28.
    Department of Animal Science, Iowa State University, Ames, Iowa
    Heat stress contributes to higher morbidity and mortality in humans and animals and is an agricultural economic challenge because it reduces livestock productivity. Redox balance and associated mitochondrial responses appear to play a central role in heat stress-induced skeletal muscle pathology. We have previously reported increased oxidative stress and mitochondrial content in oxidative muscle following 12 h of heat stress. Read More

    [Risk of exposure to heatstroke in sugarcane workers in São Paulo State, Brazil].
    Cad Saude Publica 2017 Apr 20;33(3):e00211415. Epub 2017 Apr 20.
    Fundação Jorge Duprat Figueiredo de Segurança e Medicina do Trabalho, Campinas, Brasil.
    Environmental heat is an aggravating factor for sugarcane workers, and manual cane cutting is one of the heavy work activities that favor the generation of metabolic heat. This can combine with other precarious working conditions to produce heatstroke, potentially leading to serious complications and even death. The study aimed to quantify the risk of overheating in sugarcane cutters in São Paulo, Brazil. Read More

    A BAG3 Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy.
    Circulation 2017 Apr 25. Epub 2017 Apr 25.
    Department of Medicine, Division of Cardiology & Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC.
    Background -Critical limb ischemia (CLI) is a manifestation of peripheral artery disease (PAD) that carries significant mortality and morbidity risk in humans, although its genetic determinants remain largely unknown. We previously discovered two overlapping quantitative trait loci (QTL) in mice, Lsq-1 and Civq-1, that affected limb muscle survival and stroke volume following femoral artery or middle cerebral artery ligation, respectively. Here we report that a Bag3 variant (Ile81Met) segregates with tissue protection from hindlimb ischemia (HLI). Read More

    Exertional Heat Illness Among Secondary School Athletes.
    J Sch Nurs 2017 Jan 1:1059840517706104. Epub 2017 Jan 1.
    3 Mathematics and Humanities Department, Carlow University, Pittsburgh, PA, USA.
    Exertional heat illness (EHI) is a leading cause of preventable death among student athletes. While causes and preventative measures for EHI are known, school districts may not be implementing evidence-based practices. This descriptive, exploratory study explored school policies, resources, and practices of coaches in a mid-Atlantic state in the prevention and identification of EHI; 397 responded. Read More

    The Threshold Temperature and Lag Effects on Daily Excess Mortality in Harbin, China: A Time Series Analysis.
    Int J Occup Environ Med 2017 Apr;8(2):85-95
    Department of Epidemiology, Public Health College, Harbin Medical University, Harbin, China.
    Background: A large number of studies have reported the relationship between ambient temperature and mortality. However, few studies have focused on the effects of high temperatures on cardio-cerebrovascular diseases mortality (CCVDM) and their acute events (ACCVDM).

    Objective: To assess the threshold temperature and time lag effects on daily excess mortality in Harbin, China. Read More

    Round Table on Malignant Hyperthermia in Physically Active Populations: Meeting Proceedings.
    J Athl Train 2017 Apr 7;52(4):377-383. Epub 2017 Mar 7.
    Department of Health, Human Performance, and Recreation, University of Arkansas, Fayetteville.
    Context:   Recent case reports on malignant hyperthermia (MH)-like syndrome in physically active populations indicate potential associations among MH, exertional heat stroke (EHS), and exertional rhabdomyolysis (ER). However, an expert consensus for clinicians working with these populations is lacking.

    Objective:   To provide current expert consensus on the (1) definition of MH; (2) history, etiology, and pathophysiology of MH; (3) epidemiology of MH; (4) association of MH with EHS and ER; (5) identification of an MH-like syndrome; (6) recommendations for acute management of an MH-like syndrome; (7) special considerations for physically active populations; and (8) future directions for research. Read More

    Upregulation and phosphorylation of HspB1/Hsp25 and HspB5/αB-crystallin after transient middle cerebral artery occlusion in rats.
    Cell Stress Chaperones 2017 Apr 20. Epub 2017 Apr 20.
    Institute of Anatomy and Cell Biology, University of Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Germany.
    Ischemic stroke leads to cellular dysfunction, cell death, and devastating clinical outcomes. The cells of the brain react to such a cellular stress by a stress response with an upregulation of heat shock proteins resulting in activation of endogenous neuroprotective capacities. Several members of the family of small heat shock proteins (HspBs) have been shown to be neuroprotective. Read More

    Exercise rehabilitation immediately following ischemic stroke exacerbates inflammatory injury.
    Neurol Res 2017 Jun 17;39(6):530-537. Epub 2017 Apr 17.
    a China-America Institute of Neuroscience, Department of Neurology , Luhe Hospital, Capital Medical University , Beijing , China.
    Objectives: The rehabilitative benefits of physical exercise after stroke appear to be contingent upon exercise initiation timing. The present study assessed the hypothesis that very early post-stroke exercise would amplify cellular stress and increases expression of pro-inflammatory mediators, while exercise initiated later would limit the inflammation associated with cerebral ischemia/reperfusion injury.

    Methods: Adult rats were subjected to middle cerebral artery occlusion and subsequently assigned to one of seven groups: one sham injury control group, three stroke groups subjected to exercise initiated after 6, 24 hours, or 3 days of reperfusion, and three stroke groups not subjected to exercise. Read More

    Comparative Efficacy and Safety of Anti-Platelet Agents in Cerebral Ischemic Disease: A Network Meta-Analysis.
    J Cell Biochem 2017 Apr 14. Epub 2017 Apr 14.
    Department of Neurosurgery, Shigatse People's Hospital, Shigatse 857000, Xizang, P.R. China.
    We performed this network meta-analysis (NMA) to enhance the corresponding evidence of the relative efficacy and safety of different anti-platelet agents in cerebral ischemic disease. PubMed and EMBASE were searched systematically for relevant studies. Outcomes were compared using odds ratios (ORs) and 95% credible intervals (CrI). Read More

    Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation.
    Jpn Dent Sci Rev 2017 Feb 27;53(1):18-24. Epub 2016 Jun 27.
    Department of Cellular and Molecular Pharmacology, Division of Basic Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
    Obesity is defined as abnormal or excessive fat accumulation. Chronic inflammation in fat influences the development of obesity-related diseases. Many reports state that obesity increases the risk of morbidity in many diseases, including hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, sleep apnea, and breast, prostate and colon cancers, leading to increased mortality. Read More

    Pro: Heat stress as a potential etiology of Mesoamerican and Sri Lankan nephropathy: a late night consult with Sherlock Holmes.
    Nephrol Dial Transplant 2017 Apr;32(4):598-602
    Epidemics of chronic kidney disease are now recognized in Central America, Mexico, India and Sri Lanka, and there is also some evidence that similar epidemics may be occurring in the USA, Thailand and elsewhere. A common denominator for each location is manually working outside in extremely hot environments. Here we review the evidence that the primary etiology may be heat stress related to repeated subclinical or clinical acute kidney injury that eventually manifests as chronic kidney disease. Read More

    Triggering Receptor Expressed on Myeloid Cells 2, a Novel Regulator of Immunocyte Phenotypes, Confers Neuroprotection by Relieving Neuroinflammation.
    Anesthesiology 2017 Apr 10. Epub 2017 Apr 10.
    From the Departments of Anesthesiology (Q.Z., J.J., S.S., D.Z., L.M., T.J., F.B., L.X.), Orthopedic Surgery (F.L.), and Geriatrics (X.C.), Xijing Hospital, Fourth Military Medical University, Xi'an, China and Department of Anesthesiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China (Q.Z., Q.W.).
    Background: Microglia can not only detrimentally augment secondary injury but also potentially promote recovery. However, the mechanism underlying the regulation of microglial phenotypes after stroke remains unclear.

    Methods: Mice were subjected to middle cerebral artery occlusion for 60 min. Read More

    Variability in Heat Strain in Fully Encapsulated Impermeable Suits in Different Climates and at Different Work Loads.
    Ann Work Expo Health 2017 Mar;61(2):248-259
    TNO CBRN Protection, 2280AA Rijswijk, The Netherlands.
    A major concern for responders to hazardous materials (HazMat) incidents is the heat strain that is caused by fully encapsulated impermeable (NFPA 1991) suits. In a research project, funded by the US Department of Defense, the thermal strain experienced when wearing these suits was studied. Forty human subjects between the ages of 25 and 50 participated in a protocol approved by the local ethical committee. Read More

    The death of Sir Victor Horsley (1857-1916) and his burial in Amarah.
    J Hist Neurosci 2017 Apr 10:1-36. Epub 2017 Apr 10.
    a University of Queensland School of Medicine , Brisbane , Australia.
    Sir Victor Alexander Haden Horsley (1857-1916), the pioneering British neurological surgeon, passed away 100 years ago. He died young in his sixtieth year from the effects of heat stroke while serving as consulting military surgeon to the Mediterranean Expeditionary Force in Amarah, modern-day Iraq, and was buried in the now largely abandoned "Amara War Cemetery." By the time of his death in 1916, Victor Horsley had established himself as one of the most eminent innovators of modern neurological surgery. Read More

    Development of a method for estimating oesophageal temperature by multi-locational temperature measurement inside the external auditory canal.
    Int J Biometeorol 2017 Apr 8. Epub 2017 Apr 8.
    Midori Anzen Company, Tokyo, Japan.
    We aimed to develop a practical method to estimate oesophageal temperature by measuring multi-locational auditory canal temperatures. This method can be applied to prevent heatstroke by simultaneously and continuously monitoring the core temperatures of people working under hot environments. We asked 11 healthy male volunteers to exercise, generating 80 W for 45 min in a climatic chamber set at 24, 32 and 40 °C, at 50% relative humidity. Read More

    Heat stress induces intestinal injury through lysosome- and mitochondria-dependent pathway in vivo and in vitro.
    Oncotarget 2017 Mar 28. Epub 2017 Mar 28.
    Southern Medical University, Guangzhou, 510515, P.R. China.
    Damage to the small intestine secondary to heat stroke is a major factor in heat stroke-related morbidity and mortality. However, the underlying mechanisms by which heat stroke causes small intestinal lesions and dysfunction remain unclear. To explore the pathogenesis of small intestinal tissue and epithelial cell injury, the SW480 cell heat stress model and the mice heat stroke model were established to mimic heat stroke. Read More

    Evaluation of Diagnostic Codes in Morbidity and Mortality Data Sources for Heat-Related Illness Surveillance.
    Public Health Rep 2017 May/Jun;132(3):326-335. Epub 2017 Apr 5.
    2 Bureau of Epidemiology, Pennsylvania Department of Health, Harrisburg, PA, USA.
    Objectives: The primary objective of this study was to identify patients with heat-related illness (HRI) using codes for heat-related injury diagnosis and external cause of injury in 3 administrative data sets: emergency department (ED) visit records, hospital discharge records, and death certificates.

    Methods: We obtained data on ED visits, hospitalizations, and deaths for Florida residents for May 1 through October 31, 2005-2012. To identify patients with HRI, we used codes from the International Classification of Diseases, Ninth Revision, Clinical Modification ( ICD-9-CM) to search data on ED visits and hospitalizations and codes from the International Classification of Diseases, Tenth Revision ( ICD-10) to search data on deaths. Read More

    Effects of extreme temperatures on cardiovascular emergency hospitalizations in a Mediterranean region: a self-controlled case series study.
    Environ Health 2017 Apr 4;16(1):32. Epub 2017 Apr 4.
    Department of Primary Care and Population Health, University College of London, London, UK.
    Background: Cold spells and heatwaves increase mortality. However little is known about the effect of heatwaves or cold spells on cardiovascular morbidity. This study aims to assess the effect of cold spells and heatwaves on cardiovascular diseases in a Mediterranean region (Catalonia, Southern Europe). Read More

    The effects of a systematic increase in relative humidity on thermoregulatory and circulatory responses during prolonged running exercise in the heat.
    Temperature (Austin) 2016 18;3(3):455-464. Epub 2016 May 18.
    Discipline of Exercise and Sport Science, Faculty of Health Science, The University of Sydney , New South Wales, Australia.
    This study examined the thermoregulatory and circulatory responses, and exercise performance of trained distance runners during exercise in the heat (31°C) at varying relative humidity (RH). In a randomized order, 11 trained male distance runners performed 5 60 min steady-state runs at a speed eliciting 70% of VO2max in RH of 23, 43, 52, 61 and 71%. This was followed immediately with an incremental exercise test to volitional exhaustion. Read More

    Comparison of Whole-Body Cooling Techniques for Athletes and Military Personnel.
    Int J Exerc Sci 2017 1;10(2):294-300. Epub 2017 Mar 1.
    Department of Applied Medicine and Rehabilitation, Indiana State University, Terre Haute, IN, USA.
    The purpose of this study was to evaluate cooling rates of The Polar Life Pod(®), a military protocol and cold water immersion. A randomized, repeated measures design was used to compare three treatment options. Participants exercised in an environmental chamber, where they followed a military march protocol on a treadmill, followed by the application of one of three treatments: Cold water immersion tub (5 - 10 °C), Polar Life Pod® (5 - 10 °C), Ice sheets at onset (5 - 10 °C). Read More

    Evaluation of the correlation between severity of acquired idiopathic generalized anhidrosis and quality of life scores.
    J Dermatol 2017 Mar 22. Epub 2017 Mar 22.
    Department of Dermatology, Tokyo Medical and Dental University, Tokyo, Japan.
    Symptoms of acquired idiopathic generalized anhidrosis (AIGA) include heat retention and/or heat stroke due to the effects of the disorder on the perspiration ability of the whole body under thermal environmental changes or exercise. Additionally, cholinergic urticaria can also occur in these patients. AIGA has a major impact on everyday life. Read More

    Wearing graduated compression stockings augments cutaneous vasodilation in heat-stressed resting humans.
    Eur J Appl Physiol 2017 May 20;117(5):921-929. Epub 2017 Mar 20.
    Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8574, Japan.
    Purpose: We investigated whether graduated compression induced by stockings enhances cutaneous vasodilation in passively heated resting humans.

    Methods: Nine habitually active young men were heated at rest using water-perfusable suits, resulting in a 1.0 °C increase in body core temperature. Read More

    American football and fatal exertional heat stroke: a case study of Korey Stringer.
    Int J Biometeorol 2017 Mar 17. Epub 2017 Mar 17.
    Department of Kinesiology, Korey Stringer Institute, University of Connecticut, Storrs, CT, 06269, USA.
    On August 1, 2001, Korey Stringer, a Pro Bowl offensive tackle for the Minnesota Vikings, became the first and to date the only professional American football player to die from exertional heat stroke (EHS). The death helped raise awareness of the dangers of exertional heat illnesses in athletes and prompted the development of heat safety policies at the professional, collegiate, and interscholastic levels. Despite the public awareness of this death, no published study has examined in detail the circumstances surrounding Stringer's fatal EHS. Read More

    Oesophageal heat exchangers with a diameter of 11mm or 14.7mm are equally effective and safe for targeted temperature management.
    PLoS One 2017 14;12(3):e0173229. Epub 2017 Mar 14.
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Cologne, Kerpener Straße 62, Cologne, Germany.
    Background: Targeted temperature management (TTM) is widely used in critical care settings for conditions including hepatic encephalopathy, hypoxic ischemic encephalopathy, meningitis, myocardial infarction, paediatric cardiac arrest, spinal cord injury, traumatic brain injury, ischemic stroke and sepsis. Furthermore, TTM is a key treatment for patients after out-of-hospital cardiac-arrest (OHCA). However, the optimal cooling method, which is quick, safe and cost-effective still remains controversial. Read More

    Hypothermia decreased the expression of heat shock proteins in neonatal rat model of hypoxic ischemic encephalopathy.
    Cell Stress Chaperones 2017 May 11;22(3):409-415. Epub 2017 Mar 11.
    Department of Pediatrics, Kyung Hee University School of Medicine, Seoul, South Korea.
    Hypothermia (HT) is a well-established neuroprotective strategy against neonatal hypoxic ischemic encephalopathy (HIE). The overexpression of heat shock proteins (HSP) has been shown to provide neuroprotection in animal models of stroke. We aimed to investigate the effect of HT on HSP70 and HSP27 expression in a neonatal rat model of HIE. Read More

    Hemostatic abnormalities in dogs with naturally occurring heatstroke.
    J Vet Emerg Crit Care (San Antonio) 2017 May 8;27(3):315-324. Epub 2017 Mar 8.
    Koret School of Veterinary Medicine, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 76100, Israel.
    Objective: To investigate hemostatic analyte abnormalities and their association with mortality in dogs with naturally occurring heatstroke.

    Design: Prospective observational study.

    Setting: University teaching hospital. Read More

    Wearable deep body thermometers and their uses in continuous monitoring for daily healthcare.
    Conf Proc IEEE Eng Med Biol Soc 2016 Aug;2016:177-180
    This paper introduces noninvasive deep body thermometers suitable for continuous deep body temperature (DBT) measurement. On the basis of their features, they were used in DBT monitoring for daily healthcare. A thermometer based on the dual-heat-flux method (T_DHFM), and an aural canal thermistor (ACT), were used in two studies of daily healthcare. Read More

    RECAST (Remote Ischemic Conditioning After Stroke Trial): A Pilot Randomized Placebo Controlled Phase II Trial in Acute Ischemic Stroke.
    Stroke 2017 May 6;48(5):1412-1415. Epub 2017 Mar 6.
    From the Department of Vascular Medicine, Division of Medical Sciences and GEM, School of Medicine (T.J.E., A.H., S.O., R.D.), Centre for Analytical Bioscience, School of Pharmacy (D.A.B., S.S.), and Stroke Trials Unit, Division of Clinical Neuroscience, School of Medicine (N.S., P.M.B.), University of Nottingham, United Kingdom.
    Background And Purpose: Repeated episodes of limb ischemia and reperfusion (remote ischemic conditioning [RIC]) may improve outcome after acute stroke.

    Methods: We performed a pilot blinded placebo-controlled trial in patients with acute ischemic stroke, randomized 1:1 to receive 4 cycles of RIC within 24 hours of ictus. The primary outcome was tolerability and feasibility. Read More

    Combined metabolic and transcriptional profiling identifies pentose phosphate pathway activation by HSP27 phosphorylation during cerebral ischemia.
    Neuroscience 2017 May 6;349:1-16. Epub 2017 Mar 6.
    Department of Neurosurgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
    The metabolic pathophysiology underlying ischemic stroke remains poorly understood. To gain insight into these mechanisms, we performed a comparative metabolic and transcriptional analysis of the effects of cerebral ischemia on the metabolism of the cerebral cortex using middle cerebral artery occlusion (MCAO) rat model. Metabolic profiling by gas-chromatography/mass-spectrometry analysis showed clear separation between the ischemia and control group. Read More

    APOA5 Gene Polymorphisms and Cardiovascular Diseases: Metaprediction in Global Populations.
    Nurs Res 2017 Mar/Apr;66(2):164-174
    Yen-Chun Lin, PhD, RN, is Assistant Professor, School of Nursing, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC. Veronica Nunez, DNP, RN, FNP-BC, is Nurse Practitioner, Vascular Surgery, Los Angeles County-University of Southern California Medical Center. Robin Johns, PhD, RN, is Associate Professor, Department of Physiological and Technological Nursing, College of Nursing, Augusta University, Georgia. S. Pamela K. Shiao, PhD, RN, FAAN, is Associate Dean for Nursing Research, Professor, and E. Louise Grant Chair, College of Nursing; Graduate Faculty, Graduate School; Faculty, Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University.
    Background: Apolipoprotein A5 (APOA5) 1131 is one of the most investigated gene polymorphisms in association with cardiovascular diseases (CVD) for its roles in epigenetics pathways.

    Objectives: The major objective of this metaprediction study was to comprehensively examine the association of polymorphism risk subtypes of APOA5 1131 gene and potential contributing factors of CVD risks in global populations.

    Methods: This study is a meta-analysis to determine APOA5 gene polymorphisms as risk factors for CVDs. Read More

    Relationship between serum anti-heat shock protein 27 antibody levels and obesity.
    Clin Biochem 2017 Feb 22. Epub 2017 Feb 22.
    Metabolic syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
    Background: Heat shock protein 27 (HSP27) is an intracellular molecular chaperone that is expressed at high levels following the exposure of cells to environmental stressors such as heat, toxins, and free radicals. High levels of HSP antigens and antibody titers have been reported in several conditions including cardiovascular disease and cancers. We measured serum anti-HSP27 antibody levels in 993 subjects and assessed the associations between serum anti-HSP27 antibody levels and demographic characteristics including coronary risk factors. Read More

    Impact of climate change on heat-related mortality in Jiangsu Province, China.
    Environ Pollut 2017 May 22;224:317-325. Epub 2017 Feb 22.
    Department of Environmental Health Sciences, Program in Climate and Health, Mailman School of Public Health, Columbia University, New York, NY, USA. Electronic address:
    A warming climate is anticipated to increase the future heat-related total mortality in urban areas. However, little evidence has been reported for cause-specific mortality or nonurban areas. Here we assessed the impact of climate change on heat-related total and cause-specific mortality in both urban and rural counties of Jiangsu Province, China, in the next five decades. Read More

    Attempts to minimize nitrogen oxide emission from diesel engine by using antioxidant-treated diesel-biodiesel blend.
    Environ Sci Pollut Res Int 2017 Apr 23;24(10):9305-9313. Epub 2017 Feb 23.
    Centre for Energy Sciences, Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, 50603, Kuala Lumpur, Malaysia.
    The study represents a comprehensive analysis of engine exhaust emission variation from a compression ignition (CI) diesel engine fueled with diesel-biodiesel blends. Biodiesel used in this investigation was produced through transesterification procedure from Moringa oleifera oil. A single cylinder, four-stroke, water-cooled, naturally aspirated diesel engine was used for this purpose. Read More

    Exertional rhabdomyolysis and heat stroke: Beware of volatile anesthetic sedation.
    World J Crit Care Med 2017 Feb 4;6(1):21-27. Epub 2017 Feb 4.
    Karel Heytens, Department of Anesthesiology, University Hospital Antwerp, 2650 Edegem, Belgium.
    In view of the enormous popularity of mass sporting events such as half-marathons, the number of patients with exertional rhabdomyolysis or exercise-induced heat stroke admitted to intensive care units (ICUs) has increased over the last decade. Because these patients have been reported to be at risk for malignant hyperthermia during general anesthesia, the intensive care community should bear in mind that the same risk of life-threatening rhabdomyolysis is present when these patients are admitted to an ICU, and volatile anesthetic sedation is chosen as the sedative technique. As illustrated by the three case studies we elaborate upon, a thorough diagnostic work-up is needed to clarify the subsequent risk of strenuous exercise, and the anesthetic exposure to volatile agents in these patients and their families. Read More

    CASE-REPORT Dysregulation of gene expression in a patient with depressive disorder after transient ischemic attack confirmed by a neurophysiological neuromarker.
    Genet Mol Res 2017 Feb 16;16(1). Epub 2017 Feb 16.
    Department of Life Sciences, Gdansk University of Physical Education and Sport, Gdańsk, Poland
Cracow Rehabilitation and Orthopedics Center, Cracow, Poland
Laboratory for the Neurobiology of Action Programming, Institute of the Human Brain, Russian Academy of Sciences, St. Petersburg, Russia
Chair of Neuropsychology, Andrzej Frycz Modrzewski University, Cracow, Poland
Center for Cognition and Communication, New York, NY, USA
    The aim of this study was to evaluate dysregulation of gene expression associated with the cellular stress response in a patient with a post-"warning stroke" depressive disorder confirmed by the presence of a neurophysiological neuromarker through the use of quantitative EEG and event-related potentials. The patient was tested for seven genes associated with the stress reaction: HSPA1A, HSPB1, IL6, IL10, CRP, and HSF-1 along with NF-κB, compared to gene expression in health controls. A 54-year-old patient with a past history of schizophrenia (at the age of 20), and of transient ischemic attack (at the age of 53) and depressive disorder confirmed by functional, cognitive, emotional, and affectional diagnostics underwent additional testing for expression of the genes associated with stress response. Read More

    Heat Acclimation Regulates the Autophagy-Lysosome Function to Protect Against Heat Stroke-Induced Brain Injury in Mice.
    Cell Physiol Biochem 2017 18;41(1):101-114. Epub 2017 Jan 18.
    Background/aims: The mechanisms underlying the protective role of heat acclimation (HA) in heat stroke (HS)-induced brain injury are still unclear. The autophagy-lysosome pathway is known to pay an important role in protecting stressed or diseased cells from death. Nevertheless, whether autophagy and lysosomes are involved in HA-mediated neuroprotection following HS exposure remains unclear. Read More

    Validity of Core Temperature Measurements at 3 Rectal Depths During Rest, Exercise, Cold-Water Immersion, and Recovery.
    J Athl Train 2017 Apr 16;52(4):332-338. Epub 2017 Feb 16.
    University of Connecticut, Storrs.
    Context:   No evidence-based recommendation exists regarding how far clinicians should insert a rectal thermistor to obtain the most valid estimate of core temperature. Knowing the validity of temperatures at different rectal depths has implications for exertional heat-stroke (EHS) management.

    Objective:   To determine whether rectal temperature (Trec) taken at 4 cm, 10 cm, or 15 cm from the anal sphincter provides the most valid estimate of core temperature (as determined by esophageal temperature [Teso]) during similar stressors an athlete with EHS may experience. Read More

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