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    1 OF 63

    Exertional rhabdomyolysis and heat stroke: Beware of volatile anesthetic sedation.
    World J Crit Care Med 2017 Feb 4;6(1):21-27. Epub 2017 Feb 4.
    Karel Heytens, Department of Anesthesiology, University Hospital Antwerp, 2650 Edegem, Belgium.
    In view of the enormous popularity of mass sporting events such as half-marathons, the number of patients with exertional rhabdomyolysis or exercise-induced heat stroke admitted to intensive care units (ICUs) has increased over the last decade. Because these patients have been reported to be at risk for malignant hyperthermia during general anesthesia, the intensive care community should bear in mind that the same risk of life-threatening rhabdomyolysis is present when these patients are admitted to an ICU, and volatile anesthetic sedation is chosen as the sedative technique. As illustrated by the three case studies we elaborate upon, a thorough diagnostic work-up is needed to clarify the subsequent risk of strenuous exercise, and the anesthetic exposure to volatile agents in these patients and their families. Read More

    CASE-REPORT Dysregulation of gene expression in a patient with depressive disorder after transient ischemic attack confirmed by a neurophysiological neuromarker.
    Genet Mol Res 2017 Feb 16;16(1). Epub 2017 Feb 16.
    Department of Life Sciences, Gdansk University of Physical Education and Sport, Gdańsk, Poland
Cracow Rehabilitation and Orthopedics Center, Cracow, Poland
Laboratory for the Neurobiology of Action Programming, Institute of the Human Brain, Russian Academy of Sciences, St. Petersburg, Russia
Chair of Neuropsychology, Andrzej Frycz Modrzewski University, Cracow, Poland
Center for Cognition and Communication, New York, NY, USA
    The aim of this study was to evaluate dysregulation of gene expression associated with the cellular stress response in a patient with a post-"warning stroke" depressive disorder confirmed by the presence of a neurophysiological neuromarker through the use of quantitative EEG and event-related potentials. The patient was tested for seven genes associated with the stress reaction: HSPA1A, HSPB1, IL6, IL10, CRP, and HSF-1 along with NF-κB, compared to gene expression in health controls. A 54-year-old patient with a past history of schizophrenia (at the age of 20), and of transient ischemic attack (at the age of 53) and depressive disorder confirmed by functional, cognitive, emotional, and affectional diagnostics underwent additional testing for expression of the genes associated with stress response. Read More

    Heat Acclimation Regulates the Autophagy-Lysosome Function to Protect Against Heat Stroke-Induced Brain Injury in Mice.
    Cell Physiol Biochem 2017 Jan 18;41(1):101-114. Epub 2017 Jan 18.
    Background/aims: The mechanisms underlying the protective role of heat acclimation (HA) in heat stroke (HS)-induced brain injury are still unclear. The autophagy-lysosome pathway is known to pay an important role in protecting stressed or diseased cells from death. Nevertheless, whether autophagy and lysosomes are involved in HA-mediated neuroprotection following HS exposure remains unclear. Read More

    Validity of Core Temperature Measurements at 3 Rectal Depths During Rest, Exercise, Cold-Water Immersion, and Recovery.
    J Athl Train 2017 Feb 16. Epub 2017 Feb 16.
    University of Connecticut, Storrs.
    Context:  No evidence-based recommendation exists regarding how far clinicians should insert a rectal thermistor to obtain the most valid estimate of core temperature. Knowing the validity of temperatures at different rectal depths has implications for exertional heat-stroke (EHS) management.

    Objective:  To determine whether rectal temperature (Trec) taken at 4 cm, 10 cm, or 15 cm from the anal sphincter provides the most valid estimate of core temperature (as determined by esophageal temperature [Teso]) during similar stressors an athlete with EHS may experience. Read More

    Inhibition of autophagy blocks cathepsins-tBid-mitochondrial apoptotic signaling pathway via stabilization of lysosomal membrane in ischemic astrocytes.
    Cell Death Dis 2017 Feb 16;8(2):e2618. Epub 2017 Feb 16.
    Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Science; Department of Pharmacology and Laboratory of Cerebrovascular Pharmacology; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, Suzhou, China.
    Our previous study and others have demonstrated that autophagy is activated in ischemic astrocytes and contributes to astrocytic cell death. However, the mechanisms of ischemia-induced autophagy remain largely unknown. In this study, we established a rat's model of permanent middle cerebral artery occlusion (pMCAO) and an in vitro oxygen and glucose deprivation (OGD) model. Read More

    Impacts of extremely high temperature and heatwave on heatstroke in Chongqing, China.
    Environ Sci Pollut Res Int 2017 Feb 13. Epub 2017 Feb 13.
    National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, 7 Panjiayuan Nanli, Beijing, 100021, China.
    Few studies have reported the quantitative association between heat and heatstroke (HS) occurrence, particularly in China. The aim of this study was to quantitatively assess the association between high temperature/heatwave and HS occurrence in Chongqing. The daily HS data from 2009 to 2013 of Chongqing were extracted from Chongqing Center for Disease Control and Prevention. Read More

    Neurologic complications of acute environmental injuries.
    Handb Clin Neurol 2017 ;141:685-704
    Neurological Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address:
    Environmental injuries can result in serious neurologic morbidity. This chapter reviews neurologic complications of thermal burns, smoke inhalation, lightning strikes, electric injury, near drowning, decompression illness, as well as heat stroke and accidental hypothermia. Knowing the pathophysiology and clinical presentation of such injuries is essential to proper management of primary and secondary medical complications. Read More

    Unexpected extrapyramidal symptoms and pulmonary aspergillosis in exertional heatstroke with fulminant liver failure: a case report.
    J Med Case Rep 2017 Feb 10;11(1):37. Epub 2017 Feb 10.
    Critical Care Medicine, Chinese PLA General Hospital, 28th Fuxing Road, Haidian District, Beijing, 100853, China.
    Background: Exertional heatstroke is a life-threatening condition with high mortality because of the rapid progress of multiple organ dysfunction syndrome even if aggressive treatments are initiated rapidly. Mild to moderate hepatic injury is common in exertional heatstroke, while fulminant liver failure is rare. Extrapyramidal symptoms and pulmonary aspergillosis secondary to liver failure induced by exertional heatstroke have never been reported in prior cases. Read More

    Cardiovascular adjustments to heat stress during prolonged exercise.
    J Sports Med Phys Fitness 2017 Feb 8. Epub 2017 Feb 8.
    Exercise, Health & Performance, Faculty of Health Sciences, University of Sydney, Sydney, NSW, Australia.
    Prolonged effort in hot environments is increasing popular in extreme sports. The number of long distance athletes taking part in races in extremely warm condition, as in deserts, is larger than in the past and also the race distances are increased thus. The demanding for the heart function are higher than those challenged in the past only by few athletes and in easier conditions. Read More

    Simple and effective method to lower body core temperatures of hyperthermic patients.
    Am J Emerg Med 2017 Jan 30. Epub 2017 Jan 30.
    CSA Medical, Inc., 91 Hartwell Avenue, Lexington, MA 02421, USA. Electronic address:
    Hyperthermia is a potentially life threatening scenario that may occur in patients due to accompanying morbidities, exertion, or exposure to dry and arid environmental conditions. In particular, heat stroke may result from environmental exposure combined with a lack of thermoregulation. Key clinical findings in the diagnosis of heatstroke are (1) a history of heat stress or exposure, (2) a rectal temperature greater than 40 °C, and (3) central nervous system dysfunction (altered mental state, disorientation, stupor, seizures, or coma) (Prendergast and Erickson, 2014 [1]). Read More

    Evaluation of Various Cooling Systems After Exercise-Induced Hyperthermia.
    J Athl Train 2017 Feb 3. Epub 2017 Feb 3.
    Combat Protection and Performance, Defence Medical and Environmental Research Institute, Singapore.
    Context:  Rapid diagnosis and expeditious cooling of individuals with exertional heat stroke is paramount for survival.

    Objective:  To evaluate the efficacy of various cooling systems after exercise-induced hyperthermia.

    Design:  Crossover study. Read More

    NCAA Football Off-Season Training: Unanswered Prayers…A Prayer Answered.
    J Athl Train 2017 Jan 31. Epub 2017 Jan 31.
    University of Oklahoma, Norman.
    Off-season training in year-round collegiate football is purported to be performance enhancing. Absent principles of exercise physiology, excesses in sport-training regimens pose risk to the participant athletes. Since 2000, 32 National Collegiate Athletic Association (NCAA) football players have died in sport: 26 nontraumatic deaths and 6 traumatic deaths, a ratio of more than 4 nontraumatic deaths for every traumatic death. Read More

    Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood-brain barrier disruption after ischemic brain injury.
    Proc Natl Acad Sci U S A 2017 Feb 30;114(7):E1243-E1252. Epub 2017 Jan 30.
    State Key Laboratory of Medical Neurobiology, Institute of Brain Sciences and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China;
    The damage borne by the endothelial cells (ECs) forming the blood-brain barrier (BBB) during ischemic stroke and other neurological conditions disrupts the structure and function of the neurovascular unit and contributes to poor patient outcomes. We recently reported that structural aberrations in brain microvascular ECs-namely, uncontrolled actin polymerization and subsequent disassembly of junctional proteins, are a possible cause of the early onset BBB breach that arises within 30-60 min of reperfusion after transient focal ischemia. Here, we investigated the role of heat shock protein 27 (HSP27) as a direct inhibitor of actin polymerization and protectant against BBB disruption after ischemia/reperfusion (I/R). Read More

    Heat stroke leading to acute liver injury & failure: A case series from the Acute Liver Failure Study Group.
    Liver Int 2017 Jan 27. Epub 2017 Jan 27.
    Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, TX, USA.
    Background & Aims: In the United States, nearly 1000 annual cases of heat stroke are reported but the frequency and outcome of severe liver injury in such patients is not well described. The aim of this study was to describe cases of acute liver injury (ALI) or failure (ALF) caused by heat stroke in a large ALF registry.

    Methods: Amongst 2675 consecutive subjects enrolled in a prospective observational cohort of patients with ALI or ALF between January 1998 and April 2015, there were eight subjects with heat stroke. Read More

    Effect of ulinastatin, a human urinary protease inhibitor, on heatstroke-induced apoptosis and inflammatory responses in rats.
    Exp Ther Med 2017 Jan 23;13(1):335-341. Epub 2016 Nov 23.
    Department of Neurology, 401 Hospital of Chinese People's Liberation Army, Qingdao, Shandong 266100, P.R.China.
    Ulinastatin has been demonstrated to protect against heatstroke by reducing cerebral ischemia and damage in rats. In order to extend these observations, apoptosis and systemic inflammatory responses were assessed in rats treated with ulinastatin prior to the initiation of heatstroke. Following the onset of heatstroke, histological analysis revealed that the hippocampal tissues displayed edema and damage. Read More

    Assessment of Vascular Stent Heating with Repetitive Transcranial Magnetic Stimulation.
    J Stroke Cerebrovasc Dis 2017 Jan 20. Epub 2017 Jan 20.
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio; Department of Physical Medicine and Rehabilitation, Neurological Institute, Cleveland Clinic Foundation, Cleveland, Ohio. Electronic address:
    Objective: A high proportion of patients with stroke do not qualify for repetitive transcranial magnetic stimulation (rTMS) clinical studies due to the presence of metallic stents. The ultimate concern is that any metal could become heated due to eddy currents. However, to date, no clinical safety data are available regarding the risk of metallic stents heating with rTMS. Read More

    Quercetin protects against heat stroke-induced myocardial injury in male rats: Antioxidative and antiinflammatory mechanisms.
    Chem Biol Interact 2017 Jan 16;265:47-54. Epub 2017 Jan 16.
    Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan, ROC. Electronic address:
    Heat stroke is characterized by hyperthermia, systemic inflammation, and multiple organ failure including arterial hypotension. This definition can be fulfilled by a rat model of heat stroke used in the present study. Anesthetized animals were exposed to heat exposure (43 °C for 70 min) and then returned to room temperature (26 °C) for recovery. Read More

    Regulation of mRNA following brain ischemia and reperfusion.
    Wiley Interdiscip Rev RNA 2017 Jan 17. Epub 2017 Jan 17.
    Department of Physiology, Wayne State University, Detroit, MI, USA.
    There is growing appreciation that mRNA regulation plays important roles in disease and injury. mRNA regulation and ribonomics occur in brain ischemia and reperfusion (I/R) following stroke and cardiac arrest and resuscitation. It was recognized over 40 years ago that translation arrest (TA) accompanies brain I/R and is now recognized as part of the intrinsic stress responses triggered in neurons. Read More

    Speed and efficiency limits of multilevel incoherent heat engines.
    Phys Rev E 2016 Dec 6;94(6-1):062109. Epub 2016 Dec 6.
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot 7610001, Israel.
    We present a comprehensive theory of heat engines (HE) based on a quantum-mechanical "working fluid" (WF) with periodically modulated energy levels. The theory is valid for any periodicity of driving Hamiltonians that commute with themselves at all times and do not induce coherence in the WF. Continuous and stroke cycles arise in opposite limits of this theory, which encompasses hitherto unfamiliar cycle forms, dubbed here hybrid cycles. Read More

    Heat Maps of Hypertension, Diabetes Mellitus, and Smoking in the Continental United States.
    Circ Cardiovasc Qual Outcomes 2017 Jan;10(1)
    From the Department of Epidemiology (M.S.L., E.B.L.) and Department of Biostatistics (G.H.), School of Public Health, University of Alabama at Birmingham; Department of Epidemiology & Biostatistics and Department of Statistics & Probability, Michigan State University, East Lansing (G.d.l.C.); Universities Space Research Association, NASA Marshall Space Flight Center, Huntsville, AL (M.Z.A.-H.); Division of General Internal Medicine, Weill Department of Medicine, Weill Cornell Medical College, New York, NY (M.M.S.); and Department of Epidemiology and Biostatistics, Drexel University, Philadelphia, PA (L.A.M.).
    Background: Geographic variations in cardiovascular mortality are substantial, but descriptions of geographic variations in major cardiovascular risk factors have relied on data aggregated to counties. Herein, we provide the first description of geographic variation in the prevalence of hypertension, diabetes mellitus, and smoking within and across US counties.

    Methods And Results: We conducted a cross-sectional analysis of baseline risk factor measurements and latitude/longitude of participant residence collected from 2003 to 2007 in the REGARDS study (Reasons for Geographic and Racial Differences in Stroke). Read More

    Chemical composition and antioxidant activities of essential oils from different parts of the oregano.
    J Zhejiang Univ Sci B 2017 Jan.;18(1):79-84
    College of Pharmacy, Hubei University of Traditional Chinese Medicine, Wuhan 430065, China.
    This research was undertaken in order to characterize the chemical compositions and evaluate the antioxidant activities of essential oils obtained from different parts of the Origanum vulgare L. It is a medicinal plant used in traditional Chinese medicine for the treatment of heat stroke, fever, vomiting, acute gastroenteritis, and respiratory disorders. The chemical compositions of the three essential oils from different parts of the oregano (leaves-flowers, stems, and roots) were identified by gas chromatography-mass spectrometry (GC-MS). Read More

    [Investigation of emergency capacities for occupational hazard accidents in silicon solar cell producing enterprises].
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2016 Nov;34(11):819-821
    Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
    Objective: To investigate and analyze the influential factors of occupational hazard acci-dents, emergency facilities and emergency management in Silicon solar cell producing enterprises, then to pro-vide scientific strategies. Methods: The methods of occupationally healthy field investigating, inspecting of ven-tilation effectiveness, setup of emergency program and wearing chemical suit were used. Results: The mainly occupational hazard accidents factors in the process of Silicon solar cell producing included poisoning chemi-cals, high temperature, onizing radiation and some workplaces. Read More

    Reactive oxygen species mediate heat stress-induced apoptosis via ERK dephosphorylation and Bcl-2 ubiquitination in human umbilical vein endothelial cells.
    Oncotarget 2016 Dec 25. Epub 2016 Dec 25.
    Southern Medical University, Guangzhou 510515, P.R. China. Department of Intensive Care Unit, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, P.R. China.
    Heat stress can induce the mitochondrial apoptotic pathway in HUVEC cells, indicating that apoptosis may be a prominent pathological feature of heat stroke, however, little is known about the precise mechani sms involved in it. In this study, we describe the apoptotic effect of intense heat stress on HUVEC cells and our investigation of its underlying mechanisms. Treatment of cells with intense heat stress induced production of reactive oxygen species (ROS) and a concomitant increase in activation of the mitochondrial apoptotic pathway. Read More

    CAERvest® - a novel endothermic hypothermic device for core temperature cooling: safety and efficacy testing.
    Int J Occup Saf Ergon 2017 Feb 2:1-11. Epub 2017 Feb 2.
    a Centre for Sport and Exercise Science and Medicine (SeSAME), Environmental Extremes Laboratory , University of Brighton , UK.
    Introduction: Cooling of the body is used to treat hyperthermic individuals with heatstroke or to depress core temperature below normal for neuroprotection. A novel, chemically activated, unpowered cooling device, CAERvest®, was investigated for safety and efficacy.

    Methods: Eight healthy male participants (body mass 79. Read More

    Climate change, heat, and mortality in the tropical urban area of San Juan, Puerto Rico.
    Int J Biometeorol 2016 Dec 15. Epub 2016 Dec 15.
    Laboratory of Atmospheric Sciences, University of Puerto Rico-Carolina Campus, P.O. Box 4800, Carolina, 00984-4800, Puerto Rico.
    Extreme heat episodes are becoming more common worldwide, including in tropical areas of Australia, India, and Puerto Rico. Higher frequency, duration, and intensity of extreme heat episodes are triggering public health issues in most mid-latitude and continental cities. With urbanization, land use and land cover have affected local climate directly and indirectly encouraging the Urban Heat Island effect with potential impacts on heat-related morbidity and mortality among urban populations. Read More

    Heat stroke with bimodal rhabdomyolysis: a case report and review of the literature.
    J Intensive Care 2016 1;4:71. Epub 2016 Dec 1.
    Department of Acute Critical Care Medicine, Shizuoka Hospital, Juntendo University, Tokyo, Japan ; 1129 Nagaoka, Izunokuni City, Shizuoka 410-2295 Japan.
    Background: Severe heat stroke tends to be complicated with rhabdomyolysis, especially in patients with exertional heat stroke. Rhabdomyolysis usually occurs in the acute phase of heat stroke. We herein report a case of heat stroke in a patient who experienced bimodal rhabdomyolysis in the acute and recovery phases. Read More

    Differential Interstrain Susceptibility to Vertebrobasilar Dolichoectasia in a Mouse Model.
    AJNR Am J Neuroradiol 2016 Dec 15. Epub 2016 Dec 15.
    From the Department of Radiology (Y.-Q.Z., H.X., D.D., D.F.K., R.K.), Mayo Clinic, Rochester, Minnesota; Department of Radiology (Y.-Q.Z.), Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China; and Department of Pathology (H.X.), Shanghai East Hospital, Medical School of Shanghai Tongji University, Shanghai, China.
    Background And Purpose: Vetebrobasilar dolichoectasia is characterized by arterial elongation, dilation, and tortuosity and leads to high risks of ischemic stroke. Our aim was to investigate the differential susceptibility to elastase-induced vertebrobasilar dolichoectasia induction in 2 different mouse strains.

    Materials And Methods: Elastase (25 mU) was injected into the cisterna magna in C57BL/6J (n = 36) and 129/SvEv (SV129) (n = 36) mice. Read More

    Association Between Exercise-Induced Hyperthermia and Intestinal Permeability: A Systematic Review.
    Sports Med 2016 Dec 10. Epub 2016 Dec 10.
    Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, 6627 Avenida Antônio Carlos, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
    Background: Prolonged and strenuous physical exercise increases intestinal permeability, allowing luminal endotoxins to translocate through the intestinal barrier and reach the bloodstream. When recognized by the immune system, these endotoxins trigger a systemic inflammatory response that may affect physical performance and, in severe cases, induce heat stroke. However, it remains to be elucidated whether there is a relationship between the magnitude of exercise-induced hyperthermia and changes in intestinal permeability. Read More

    Neuroprotection of hypoxic postconditioning against global cerebral ischemia through influencing posttranslational regulations of heat shock protein 27 in adult rats.
    Brain Pathol 2016 Dec 9. Epub 2016 Dec 9.
    Institute of Neurosciences and the Second Affiliated Hospital of Guangzhou Medical University, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Collaborative Innovation Center for Neurogenetics and Channelopathies, Guangzhou, 510260, China.
    We previously reported that hypoxic postconditioning (HPC) ameliorated hippocampal neuronal death induced by transient global cerebral ischemia (tGCI) in adult rats. However, the mechanism of HPC-induced neuroprotection is still elusive. Notably, heat shock protein 27 (Hsp27) has recently emerged as a potent neuroprotectant in cerebral ischemia. Read More

    Unique cytokine and chemokine responses to exertional heat stroke in mice.
    J Appl Physiol (1985) 2017 Feb 1;122(2):296-306. Epub 2016 Dec 1.
    Department of Applied Physiology and Kinesiology, College of Health and Human Performance, The University of Florida; and
    In heat stroke, cytokines are believed to play important roles in multiorgan dysfunction and recovery of damaged tissue. The time course of the cytokine response is well defined in passive heat stroke (PHS), but little is known about exertional heat stroke (EHS). In this study we used a recently developed mouse EHS model to measure the responses of circulating cytokines/chemokines and cytokine gene expression in muscle. Read More

    Cooling Effectiveness of a Modified Cold-Water Immersion Method After Exercise-Induced Hyperthermia.
    J Athl Train 2016 Nov 22;51(11):946-951. Epub 2016 Nov 22.
    University of Arkansas, Fayetteville.
    Context:  Recommended treatment for exertional heat stroke includes whole-body cold-water immersion (CWI). However, remote locations or monetary or spatial restrictions can challenge the feasibility of CWI. Thus, the development of a modified, portable CWI method would allow for optimal treatment of exertional heat stroke in the presence of these challenges. Read More

    Heat stroke internet searches can be a new heatwave health warning surveillance indicator.
    Sci Rep 2016 Nov 21;6:37294. Epub 2016 Nov 21.
    Mailman School of Public Health, Columbia University, New York, USA.
    The impact of major heatwave shocks on population morbidity and mortality has become an urgent public health concern. However, Current heatwave warning systems suffer from a lack of validation and an inability to provide accurate health risk warnings in a timely way. Here we conducted a correlation and linear regression analysis to test the relationship between heat stroke internet searches and heat stroke health outcomes in Shanghai, China, during the summer of 2013. Read More

    Patient-specific CFD models for intraventricular flow analysis from 3D ultrasound imaging: Comparison of three clinical cases.
    J Biomech 2017 Jan 11;50:144-150. Epub 2016 Nov 11.
    IBiTech-bioMMeda, ELIS Department, Ghent University, Ghent, Belgium.
    Background: As the intracardiac flow field is affected by changes in shape and motility of the heart, intraventricular flow features can provide diagnostic indications. Ventricular flow patterns differ depending on the cardiac condition and the exploration of different clinical cases can provide insights into how flow fields alter in different pathologies.

    Methods: In this study, we applied a patient-specific computational fluid dynamics model of the left ventricle and mitral valve, with prescribed moving boundaries based on transesophageal ultrasound images for three cardiac pathologies, to verify the abnormal flow patterns in impaired hearts. Read More

    Core Temperature in Service Members With and Without Traumatic Amputations During a Prolonged Endurance Event.
    Mil Med 2016 Nov;181(S4):61-65
    Department of Rehabilitation, Walter Reed National Military Medical Center, Bethesda, MD 20889.
    Introduction: Service members with traumatic amputations may be at an increased risk of elevated core body temperature, since their ability to dissipate heat may decrease with the reduction in body surface area (BSA) after injury. Elevated core temperature can impair physical performance during combat operations potentially putting the service members and their teams at risk. The purpose of this study was to compare core temperature between individuals with and without amputations during a prolonged endurance event. Read More

    Bowel Ischemia from Heat Stroke: A Rare Presentation of an Uncommon Complication.
    Case Rep Med 2016 20;2016:5217690. Epub 2016 Oct 20.
    Department of Gastroenterology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA.
    A healthy 27-year-old female presented to the hospital after she collapsed an hour into her first marathon run on a hot humid day. On presentation, she was hyperthermic, encephalopathic, tachycardic, and hypotensive. On admission, she was found to have lactic acidosis, rhabdomyolysis, and acute kidney injury and was treated with cold normal saline and cooling blankets. Read More

    Scaling the low-shear pulsatile TORVAD for pediatric heart failure.
    ASAIO J 2016 Nov 9. Epub 2016 Nov 9.
    * Windmill Cardiovascular Systems, Austin, Texas † Division of Cardiovascular Medicine, University of Texas Medical School at Houston and The Memorial Hermann Heart and Vascular Institute, Houston, Texas ‡ Department of Mechanical Engineering, University of Texas at Austin, Austin, Texas.
    This article provides an overview of the design challenges associated with scaling the low-shear pulsatile TORVAD ventricular assist device (VAD) for treating pediatric heart failure. A cardiovascular system model was used to determine that a 15 ml stroke volume device with a maximum flow rate of 4 L/min can provide full support to pediatric patients with body surface areas between 0.6 to 1. Read More

    Application of an innovative technique for unilateral ovariectomy in dairy cows.
    Vet Rec 2016 Nov 5;179(18):463. Epub 2016 Sep 5.
    Department of Emergency and Organ Transplantation, University of Bari 'Aldo Moro', Strada p.le per Casamassima, km 3, 70010 Valenzano, Bari, Italy.
    This report describes an innovative unilateral ovariectomy technique for the surgical treatment of follicular cysts in dairy cows. Five cows, with a diagnosis of follicular cysts, were submitted to unilateral ovariectomy via a paralumbar fossa approach, in standing position. The linear cutter proved useful for clamping the ovary, stapling the vessels and cutting in one stroke, thus reducing surgery times. Read More

    A bibliometric analysis of exertional heat stroke research in Web of Science.
    Mil Med Res 2016 20;3:31. Epub 2016 Oct 20.
    Department of Critical Care Medicine, Chinese PLA General Hospital, Beijing, 100853 China.
    Background: Exertional heat stroke is a fatal condition and remains a health problem. This paper evaluates the publication trend regarding exertional heat stroke research between 1996 and 2015 using a bibliometric method.

    Method: Articles regarding exertional heat stroke research published between 1996 and December 2015 were searched for in the SCI-EXPANDED database of Web of Science. Read More

    Mesenchymal stem cell-based treatments for stroke, neural trauma, and heat stroke.
    Brain Behav 2016 Oct 3;6(10):e00526. Epub 2016 Aug 3.
    Department of Medical Research Chi Mei Medical Center Tainan Taiwan.
    Background: Mesenchymal stem cell (MSC) transplantation has been reported to improve neurological function following neural injury. Many physiological and molecular mechanisms involving MSC therapy-related neuroprotection have been identified.

    Methods: A review is presented of articles that pertain to MSC therapy and diverse brain injuries including stroke, neural trauma, and heat stroke, which were identified using an electronic search (e. Read More

    Phytochemical Screening and Antinociceptive and Antidiarrheal Activities of Hydromethanol and Petroleum Benzene Extract of Microcos paniculata Barks.
    Biomed Res Int 2016 29;2016:3167085. Epub 2016 Sep 29.
    Department of Pharmacy, Jessore University of Science & Technology, Jessore, Bangladesh.
    Introduction. Microcos paniculata is traditionally used for treating diarrhea, wounds, cold, fever, hepatitis, dyspepsia, and heat stroke. Objective. Read More

    Targeting Glial Mitochondrial Function for Protection from Cerebral Ischemia: Relevance, Mechanisms, and the Role of MicroRNAs.
    Oxid Med Cell Longev 2016 29;2016:6032306. Epub 2016 Sep 29.
    Department of Anesthesiology, Perioperative & Pain Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5117, USA.
    Astrocytes and microglia play crucial roles in the response to cerebral ischemia and are effective targets for stroke therapy in animal models. MicroRNAs (miRs) are important posttranscriptional regulators of gene expression that function by inhibiting the translation of select target genes. In astrocytes, miR expression patterns regulate mitochondrial function in response to oxidative stress via targeting of Bcl2 and heat shock protein 70 family members. Read More

    Revised guideline for the diagnosis and treatment of acquired idiopathic generalized anhidrosis in Japan.
    J Dermatol 2016 Oct 24. Epub 2016 Oct 24.
    Department of Dermatology, Tokyo Medical and Dental University, Tokyo, Japan.
    Acquired idiopathic generalized anhidrosis (AIGA) is characterized by an acquired impairment in total body sweating despite exposure to heat or exercise. Severe cases may result in heatstroke. Most cases of AIGA have been reported in Asia, especially in Japan. Read More

    Cardioprotective effects of monocyte locomotion inhibitory factor on myocardial ischemic injury by targeting vimentin.
    Life Sci 2016 Dec 20;167:85-91. Epub 2016 Oct 20.
    Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai, PR China; Department of Pharmacy, Punan Hospital, Pudong New District, Shanghai, PR China. Electronic address:
    Monocyte locomotion inhibitory factor (MLIF), a heat-stable pentapeptide produced by Entamoeba histolytica, has anti-inflammatory function and protective effect on ischemic stroke. In this study, we evaluated the effect of MLIF on myocardial ischemia. Mice were subjected to ischemia/reperfusion by occlusion of the left anterior descending artery (LAD). Read More

    Investigation on the emission quality, performance and combustion characteristics of the compression ignition engine fueled with environmental friendly corn oil methyl ester - Diesel blends.
    Ecotoxicol Environ Saf 2016 Dec 2;134(Pt 2):455-461. Epub 2016 Feb 2.
    Department of Mechanical Engineering, SNS College of Engineering, Coimbatore 641107, India. Electronic address:
    This paper deals with emission quality of diesel engine based on eco toxicological studies with different methods of environmental standard toxicity tests satisfy the Bharath and European emission norms. Based on the emission norms, Corn Oil Methyl Ester (COME) with diesel is tested in a compression ignition engine and the performance and combustion characteristics are discussed. The corn oil was esterified and the property of corn oil methyl ester was within the limits specified in ASTM D 6751-03. Read More

    Delayed vestibulopathy after heat exposure.
    J Neurol 2017 Jan 20;264(1):49-53. Epub 2016 Oct 20.
    Department of Neurology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 173-82 Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, Korea.
    Even though dizziness is a common symptom of heat illness, comprehensive evaluation of the vestibular function has not been available in this potentially life-threatening disorder. Three patients developed vertigo about a week after heat exposure. Evaluation showed bilateral impairments of the vestibulo-ocular reflex during head impulses and the signs of vestibulocerebellar dysfunction that included spontaneous downbeat nystagmus, gaze-evoked nystagmus, and positional downbeat nystagmus. Read More

    Seasonal and Geographic Variation in Adverse Event Reporting.
    Drugs Real World Outcomes 2016 Sep;3(3):297-306
    Pfizer Inc., New York, NY, USA.
    Background: Many illnesses demonstrate seasonal and geographic variations. Pharmacovigilance is unique among public health surveillance systems in terms of the clinical diversity of the events under surveillance. Since many pharmacovigilance signal detection methodologies are geared towards looking for increased frequency of spontaneous adverse drug event (ADE) reporting over variable time frames, seasonality of ADEs may have implications for signal detection. Read More

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