3,796 results match your criteria Heatstroke


Risk perception of heat related disorders on the workplaces: a survey among health and safety representatives from the autonomous province of Trento, Northeastern Italy.

J Prev Med Hyg 2020 Mar 2;61(1):E48-E59. Epub 2020 Apr 2.

ASST di Cremona; Direzione Medica di Presidio, Cremona (Italy).

Introduction: This study will investigate knowledge, attitude and practices towards heat-related health issues in a sample of safety representatives from Northern Italy (H&SRs).

Methods: A cross-sectional questionnaire survey was conducted in 2016-2017 among 298 H&SR. Knowledge status was measured both in general but as well and focusing on first-aid issues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15167/2421-4248/jpmh2020.61.1.727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225649PMC

Mesenchymal Stem Cells Provide Neuroprotection by Regulating Heat Stroke-Induced Brain Inflammation.

Front Neurol 2020 5;11:372. Epub 2020 May 5.

Department of Critical Care Medicine, General Hospital of the Chinese People's Liberation Army, Beijing, China.

Heat stroke (HS) is the most acute type of heat illness accompanied with serious central nervous system (CNS) dysfunction. Despite the pathological process being clearly studied, effective treatment is deficient. Currently, mesenchymal stem cells (MSCs) have been demonstrated to have neuroprotective effects as there are no old ones. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fneur.2020.00372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232542PMC

High ambient temperature in summer and risk of stroke or transient ischemic attack: A national study in Israel.

Environ Res 2020 May 20;187:109678. Epub 2020 May 20.

School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel. Electronic address:

Objective: To examine whether high ambient temperature and diurnal temperature range during the summer are associated with risk of stroke/transient ischemic attack (TIA).

Methods: A time-stratified case-crossover study design was conducted. The study sample comprised all individuals aged ≥50 years who had a stroke/TIA reported to the Israeli National Stroke Registry between 2014 and 2016 during the summer season. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envres.2020.109678DOI Listing

Pediatric Heatstroke Fatalities Caused by Being Left in Motor Vehicles.

Pediatr Emerg Care 2020 May 28. Epub 2020 May 28.

KidsAndCars.org, Philadelphia, PA.

Objectives: Fatalities due to being left in motor vehicles is an important cause of pediatric mortality. Few studies in the medical literature focus on this topic. This study aims to describe the circumstances surrounding these deaths, to determine their geographic distribution, and to evaluate the legal consequences for those responsible. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PEC.0000000000002115DOI Listing

Hydration and Cooling Strategies for Paralympic Athletes : Applied Focus: Challenges Athletes May Face at the Upcoming Tokyo Paralympics.

Curr Nutr Rep 2020 May 29. Epub 2020 May 29.

United States Olympic & Paralympic Committee, 1 Olympic Plaza, Colorado Springs, CO, 80909, USA.

Purpose Of Review: Effective thermoregulation is paramount for optimizing athletic performance and minimizing the risk of heat illness when exercising, especially in hot conditions. Para-athletes can face unique challenges in regard to thermoregulation and hydration, especially when travel is involved.

Recent Findings: For example, athletes with spinal cord injuries (SCI) have an impaired ability to thermoregulate due to a decreased sweat rate and ability to dissipate heat, thus making vigorous activity in the heat a challenge. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13668-020-00317-1DOI Listing

Variations in the TRPV1 gene are associated to exertional heat stroke.

J Sci Med Sport 2020 May 18. Epub 2020 May 18.

CHU Grenoble Alpes IBP, Génétique Moléculaire : Maladies Héréditaires et Oncologie, France; Grenoble Institute of Neurosciences, Inserm U1216, Cellular Myology and Pathology, Grenoble Alpes, University, Grenoble, France.

Objectives: Exertional Heat Stroke (EHS) is one of the top three causes of sudden death in athletes. Extrinsic and intrinsic risk factors have been identified but the genetic causes still remain unclear. Our aim was to identify genes responsible for EHS, which is a necessary step to identify patients at risk and prevent crises. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsams.2020.04.018DOI Listing

Heat stress induces RIP1/RIP3-dependent necroptosis through the MAPK, NF-κB, and c-Jun signaling pathways in pulmonary vascular endothelial cells.

Biochem Biophys Res Commun 2020 May 26. Epub 2020 May 26.

Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address:

Necroptosis represents a newly defined form of regulated necrosis and participates in various human inflammatory diseases. It remains unclear whether necroptosis is presented in heatstroke-induced lung injury. We show that heat stress(HS) triggered an significant upregulation of receptor-interacting protein 1 (RIP1) and mixed lineage kinase domain-like protein (MLKL) expression in a time-dependent manner, without a significant change of receptor-interacting protein 3 (RIP3). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2020.04.150DOI Listing

Impact of Severe Pulmonary Hypertension on Right Heart Hemodynamics and Outcomes Following Cardiac Transplantation: A Single Center Experience.

J Heart Lung Transplant 2020 Apr 30;39(4S):S289. Epub 2020 Mar 30.

Cardiac Surgery, Sant'Orsola Malpighi Hospital, Bologna, Italy.

Purpose: The prognostic impact of pulmonary hypertension (PH) is debated as well as the trend of pulmonary hemodynamic variables after heart transplantation (HTx). We investigated the impact of preoperative PH on postoperative survival and on the evolution of right heart hemodynamics (RHH) after HTx.

Methods: We reviewed the records of 431 consecutive HTx recipients, divided in a non-PH group (270 pts) and a PH group (161 pts). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.healun.2020.01.640DOI Listing

Decompression Surgery, Fabric Masks, Heat Stroke, e-Cigarette Use.

Authors:

Am Fam Physician 2020 Jun;101(11):648

View Article

Download full-text PDF

Source

Assessment of computed tomography perfusion software in predicting spatial location and volume of infarct in acute ischemic stroke patients: a comparison of Sphere, Vitrea, and RAPID.

J Neurointerv Surg 2020 May 26. Epub 2020 May 26.

Biomedical Engineering, University at Buffalo-The State University of New York, Buffalo, New York, USA

Background: CT perfusion (CTP) infarct and penumbra estimations determine the eligibility of patients with acute ischemic stroke (AIS) for endovascular intervention. This study aimed to determine volumetric and spatial agreement of predicted RAPID, Vitrea, and Sphere CTP infarct with follow-up fluid attenuation inversion recovery (FLAIR) MRI infarct.

Methods: 108 consecutive patients with AIS and large vessel occlusion were included in the study between April 2019 and January 2020 . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/neurintsurg-2020-015966DOI Listing

Expression profiles of genes associated with inflammatory responses and oxidative stress in lung after heat stroke.

Biosci Rep 2020 May 21. Epub 2020 May 21.

The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background: HS is a physically dysfunctional illness caused by hyperthermia. Lung, as the important place for gas-exchange and heat-dissipation organ, is often firstly to be injured. Lung injury caused by HS impairs the ventilation function of lung, which will subsequently cause damage to other tissues and organs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BSR20192048DOI Listing

Years of life lost with premature death due to ambient temperatures in a southwest plateau region of China: a cause-specific and individual characteristics stratified mortality study.

Int J Biometeorol 2020 May 20. Epub 2020 May 20.

Department of Preventive Medicine, Shantou University Medical College, Shantou, 515041, Guangdong, China.

We aimed to explore whether there were cold and heat temperature adverse effects on years of life lost (YLL) for non-accidental mortality in Yuxi, a southwest plateau region of China. From data for 89,467 non-accidental deaths over an 8-year study period, we used a general linear regression model combined with a distributed lag non-linear model to assess the burden of disease non-accidental mortality due to ambient temperature with the YLL indicator. We estimated the mean YLL change per 1 °C decrease from the 25th to 1st percentile mean temperature as the cold effect and per 1 °C increase from the 75th to 99th percentile as the heat effect. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00484-020-01912-1DOI Listing
May 2020
3.246 Impact Factor

Preventing necroptosis by scavenging ROS production alleviates heat stress-induced intestinal injury.

Int J Hyperthermia 2020 ;37(1):517-530

Academy of Orthopedics, Guangdong Province, Guangdong Provincial Key Laboratory of Bone and Joint Degenerative Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.

Worldwide heat stroke incidence has increased in recent years and is associated with high morbidity and mortality. Therefore, it is critical to identify mechanisms that mediate heat stroke. Previous studies suggested that damage to the small intestine may be a major factor in heat stroke-related morbidity and mortality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/02656736.2020.1763483DOI Listing
January 2020

Mechanism of Huang-lian-Jie-du decoction and its effective fraction in alleviating acute ulcerative colitis in mice: Regulating arachidonic acid metabolism and glycerophospholipid metabolism.

J Ethnopharmacol 2020 May 14;259:112872. Epub 2020 May 14.

Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China. Electronic address:

Ethnopharmacological Relevance: Huang-lian-Jie-du decoction (HLJDD) is a traditional Chinese medicine prescription for clearing away heat, purging fire and detoxifying, which can be used to treat sepsis, stroke, Alzheimer's disease and gastrointestinal diseases. Our previous studies have shown that HLJDD can effectively alleviate acute ulcerative colitis (UC) in mice, and its n-butanol fraction (HLJDD-NBA) is the effective fraction. The aim of this study is to further investigate the mechanism of HLJDD and HLJDD-NBA in relieving UC in mice from a holistic perspective. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2020.112872DOI Listing

Estimated and measured core temperature responses to high-intensity warm weather military training: implications for exertional heat illness risk assessment.

Physiol Meas 2020 May 14. Epub 2020 May 14.

Applied Physiology, Institute of Naval Medicine, Alverstokre, Gosport, PO12 2DL, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Objective: Humans avoid overheating through physiological and behavioral mechanisms. However, elite athletes, industrial workers, and military personnel, driven by the tasks at hand, may choose to continue working and face an increased risk of exertional heat illness (EHI). We wanted to examine the efficacy of a new core temperature (Tcr) estimation algorithm in assessing EHI risk. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6579/ab934bDOI Listing

The prognostic value of routine coagulation tests for patients with heat stroke.

Am J Emerg Med 2020 Apr 22. Epub 2020 Apr 22.

Department of Emergency, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Objective: To evaluate the prognostic value of routine coagulation tests for patients with heat stroke.

Methods: This was a multi-center retrospective study. Patients who arrived at the hospital <24 h after the onset of Heat Stroke (HS) were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajem.2020.04.062DOI Listing

Acute Myocardial Infarction among Hospitalizations for Heat Stroke in the United States.

J Clin Med 2020 May 6;9(5). Epub 2020 May 6.

Department of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok 10400, Thailand.

Background: This study aimed to assess the risk factors and impact of acute myocardial infarction on in-hospital treatments, complications, outcomes, and resource utilization in hospitalized patients for heat stroke in the United States.

Methods: Hospitalized patients with a principal diagnosis of heat stroke were identified in the National Inpatient Sample dataset from the years 2003 to 2014. Acute myocardial infarction was identified using the hospital International Classification of Diseases, Ninth Revision (ICD-9), diagnosis of 410. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm9051357DOI Listing

Myricetin against myocardial injury in rat heat stroke model.

Biomed Pharmacother 2020 Jul 1;127:110194. Epub 2020 May 1.

Department of Medical Imaging, The 960th Hospital of Joint Logistics Support Force of PLA, Shandong Province, China. Electronic address:

Background: Heat stroke-induced mortality is rising across the globe. So, the design of prophylactic and/or therapeutic modalities for heat stroke is pressing need. The common plant derived flavonoid exhibits strong anti-oxidant and anti-inflammatory activities; however, its effects in heat stroke remain unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biopha.2020.110194DOI Listing

Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model.

J Thromb Haemost 2020 May 4. Epub 2020 May 4.

Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, MA, USA.

Background: Immune challenge is known to increase heat stroke risk, although the mechanism of this increased risk is unclear.

Objectives: We sought to understand the effect of immune challenge on heat stroke pathology.

Patients/methods: Using a mouse model of classic heat stroke, we examined the impact of prior viral or bacterial infection on hematological aspects of recovery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jth.14875DOI Listing

Prior viral illness increases heat stroke severity in mice.

Exp Physiol 2020 May 2. Epub 2020 May 2.

US Army Research Institute of Environmental Medicine, Thermal Mountain Medicine Division, Natick, MA, USA.

New Findings: What is the central question of this study? We hypothesized that prior illness would increase the susceptibility to and severity of heat stroke (HS). What is the main finding and its importance? We provide the first experimental evidence, using a mouse model of HS, that recent viral illness increases the severity of HS. Our data indicate that this effect is not attributable to the exacerbation of hyperthermia but is a consequence of ongoing coagulation and systemic inflammatory reactions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1113/EP088480DOI Listing

Cigarette Smoking Cessation Temporarily Enhances the Release of Phosphorylated-HSP27 from Human Platelets.

Intern Med 2020 Apr 30. Epub 2020 Apr 30.

Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Japan.

Objective Cigarette smoking is a risk factor for arteriopathy, including acute coronary syndrome, stroke and peripheral vascular disease. Thus, cessation is strongly recommended in order to reduce these risks. We recently demonstrated that smoking cessation causes temporary hyper-aggregability of human platelets. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2169/internalmedicine.4000-19DOI Listing

Heat-Related Illness Among Latinx Child Farmworkers in North Carolina: A Mixed-Methods Study.

New Solut 2020 Apr 29:1048291120920571. Epub 2020 Apr 29.

Department of Family and Community Medicine, Wake Forest School of Medicine, Winston-Salem, USA.

Children as young as ten are legally hired for farm work. In North Carolina, many of these hired children are Latinx; they often work long hours during hot and humid summer conditions. Heat-related illness occurs along a continuum of severity ranging from heat cramps and rashes to heat exhaustion and heat stroke, which can be fatal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1048291120920571DOI Listing

Evaluating the effectiveness of labor protection policy on occupational injuries caused by extreme heat in a large subtropical city of China.

Environ Res 2020 Apr 15;186:109532. Epub 2020 Apr 15.

School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China; Shanghai Key Laboratory of Meteorology and Health, Shanghai Meteorological Service, Shanghai, 200030, China; School of Public Health, Zhengzhou University, Zhengzhou, 450001, China. Electronic address:

On March 1, 2012, the Chinese government implemented the Administrative Measures on Heatstroke Prevention (AMHP2012) to combat the occupational health impacts of extreme heat, and reducing occupational injury was one of the main purposes. This study aimed at quantifying the intervention effects of the AMHP2012 on extreme heat-related occupational injuries and subsequent insurance payouts in Guangzhou, China. Data on occupational injuries and insurance payouts were collected from March 1, 2011, to February 28, 2013, from the occupational injury insurance system of Guangzhou. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envres.2020.109532DOI Listing

Update: Heat illness, active component, U.S. Armed Forces, 2019.

Authors:

MSMR 2020 Apr;27(4):4-9

In 2019, there were 507 incident cases of heat stroke and 2,174 incident cases of heat exhaustion among active component service members. The overall crude incidence rates of heat stroke and heat exhaustion were 0.39 cases and 1. Read More

View Article

Download full-text PDF

Source

Paediatric hyperthermia-related deaths while entrapped and unattended inside vehicles: The Canadian experience and anticipatory guidance for prevention.

Paediatr Child Health 2020 Apr 16;25(3):143-148. Epub 2019 Jul 16.

Faculty of Medicine, University of Toronto, Toronto, Ontario.

An average of 37 children die of hyperthermia inside parked vehicles annually in the USA. The majority of cases are due to a caregiver forgetting them (~55%), while ~13% are due to intentionally leaving children unattended and ~28% occur when children climb into unlocked vehicles. The cause of four per cent is unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/pch/pxz087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147705PMC
April 2020
1.545 Impact Factor

A Case of Exertional Heat Stroke Complicated by Hypoxic Hepatitis.

Case Rep Emerg Med 2020 30;2020:8724285. Epub 2020 Mar 30.

Department of General Internal and Emergency Medicine, Buergerspital Solothurn, Solothurn, Switzerland.

Background: Exertional heat stroke is a life-threatening condition often complicated by multiorgan failure. We hereby present a case of a 25-year-old male presenting with syncope after a 10  km run in 28°C outside temperature who developed acute liver failure. . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/8724285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149357PMC

Atypical brain imaging findings associated with heat stroke: A patient with rhabdomyolysis and acute kidney injury: A case report.

Authors:
Byung Hoon Lee

Radiol Case Rep 2020 May 8;15(5):560-563. Epub 2020 Apr 8.

Department of Radiology, Inje University Ilsan Paik Hospital, Goyang, Gyeonggido, South Korea.

Heat stroke is a serious medical condition that can cause multiple organ dysfunction, including central nervous system damage. The complications of heat stroke occur because of hypoperfusion, an inflammatory response, and thrombosis, resulting in variable imaging findings. This report describes a rare case of rapidly progressive heat stroke with rhabdomyolysis and acute kidney injury in a 53-year-old woman with atypical brain computed tomography and magnetic resonance imaging findings involving the bilateral cerebral cortex and deep gray matter but excluding the cerebellum. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.radcr.2020.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149585PMC

Diagnosis and Management of Heatstroke.

Acta Med Indones 2020 Jan;52(1):90-97

Department of Internal Medicine, Faculty of Medicine, University of Mataram - West Nusa Tenggara General Hospital.

Heatstroke is a life-threatening  and the most severe form of heat-related illnesses, characterized by body temperature >40ºC and central nervous system dysfunction. Heatstroke is classified into Non-Exertional Heatstroke (NEHS) and Exertional Heatstroke (EHS). The pathophysiology of heatstroke involves a combination of direct heat effects on the host, the systemic inflammatory and coagulopathic response. Read More

View Article

Download full-text PDF

Source
January 2020

Astrocyte-derived extracellular vesicles: Neuroreparative properties and role in the pathogenesis of neurodegenerative disorders.

J Control Release 2020 Apr 11;323:225-239. Epub 2020 Apr 11.

Institute for Regenerative Medicine, Department of Molecular and Cellular Medicine, Texas A&M University College of Medicine, College Station, TX, USA. Electronic address:

Extracellular vesicles (EVs) released by neural cells play an essential role in brain homeostasis and the crosstalk between neural cells and the periphery. EVs are diverse, nano-sized vesicles, which transport proteins, nucleic acids, and lipids between cells over short and long expanses and hence are proficient for modulating the target cells. EVs released from neural cells are implicated in synaptic plasticity, neuron-glia interface, neuroprotection, neuroregeneration, and the dissemination of neuropathological molecules. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2020.04.017DOI Listing

Novel Acclimatization and Acclimation Strategies for Hot Climates.

Curr Sports Med Rep 2020 Apr;19(4):142-145

Tripler Army Medical Center, Honolulu, HI.

Exercising in hot, humid temperatures increases the risk for heat-related illnesses, ranging from mild heat edema to severe heat stroke. With increasing globalization in the world of sports, athletes are sometimes expected to compete in unforgiving conditions that expose them to these risks. In an effort to improve exercise capacity and reduce the risk of serious heat injury, many athletes are recommended to undergo heat acclimatization program prior to competing in climates with elevated average temperature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1249/JSR.0000000000000707DOI Listing

Acute phase response to exertional heat stroke in mice.

Exp Physiol 2020 Apr 13. Epub 2020 Apr 13.

Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.

New Findings: What is the central question of this study? Exertional heat stroke is accompanied by a marked inflammatory response. In this study, we explored the time course of acute phase proteins during recovery from severe heat stress in mice and the potential role of skeletal muscles as their source. What is the main finding and its importance? Exertional heat stroke transiently increased expression of acute phase proteins in mouse liver and plasma and depleted liver and plasma fibrinogen, a typical response to severe trauma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1113/EP088501DOI Listing

[Indication of bloodletting therapy based on multi-dimensional evidence assessment].

Zhongguo Zhen Jiu 2020 Apr;40(4):450-4

Institute of Acupuncture and Moxibustion Standardization, Tianjin University of TCM, Tianjin 300193, China.

The indication of bloodletting therapy was determined based on the multi-dimensional evidence assessment, which could provide guidance for the clinical application of bloodletting therapy. The literature of bloodletting therapy was comprehensively collected by retrieval in CNKI, Wanfang and VIP databases (until February 23, 2019), modern books in Library of Tianjing University of TCM and the (Fifth Edition). The disease spectrum of bloodletting therapy was determined by self-designed questionnaire survey e-mailed to relevant experts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.13703/j.0255-2930.20190425-k0004DOI Listing

Systematic review of gender differences in the epidemiology and risk factors of exertional heat illness and heat tolerance in the armed forces.

BMJ Open 2020 Apr 6;10(4):e031825. Epub 2020 Apr 6.

Division of Tropical Health and Medicine, James Cook University, Townsville, Queensland, Australia.

Objectives: This review aimed to describe the epidemiology of all heat-related illnesses in women compared with men in the armed forces and to identify gender-specific risk factors and differences in heat tolerance.

Design: A systematic review of multiple databases (MEDLINE, Emcare, CINAHL, PsycINFO, Informit and Scopus) was conducted from the inception of the databases to 1 April 2019 using the preferred reporting items for systematic review and meta-analysis guidelines.

Eligibility Criteria: All relevant studies investigating and comparing heat illness and heat tolerance in women and men in the armed forces were included in the review. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2019-031825DOI Listing

Individual risk factors associated with exertional heat illness: A systematic review.

Exp Physiol 2020 Apr 6. Epub 2020 Apr 6.

School of Sport, Health and Wellbeing, Plymouth Marjon University, Plymouth, UK.

New Findings: What is the topic of this review? Exertional heat illness (EHI) remains a persistent problem for athletes and individuals. This threat remains despite numerous athletic position statements and occupational guidance policies. This review explores primary evidence that demonstrates a direct association between 'known' risk factors and EHI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1113/EP088458DOI Listing

The Chemical Biology of Ferroptosis in the Central Nervous System.

Authors:
Rajiv R Ratan

Cell Chem Biol 2020 May 2;27(5):479-498. Epub 2020 Apr 2.

Burke Neurological Institute at Weill Cornell Medicine, 785 Mamaroneck Avenue, White Plains, NY 10605, USA. Electronic address:

Over the past five decades, thanatology has come to include the study of how individual cells in our bodies die appropriately and inappropriately in response to physiological and pathological stimuli. Morphological and biochemical criteria have been painstakingly established to create clarity around definitions of distinct types of cell death and mechanisms for their activation. Among these, ferroptosis has emerged as a unique, oxidative stress-induced cell death pathway with implications for diseases as diverse as traumatic brain injury, hemorrhagic stroke, Alzheimer's disease, cancer, renal ischemia, and heat stress in plants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chembiol.2020.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245561PMC

Translating evidence-based practice to clinical practice in Tokyo 2020: how to diagnose and manage exertional heat stroke.

Br J Sports Med 2020 Mar 27. Epub 2020 Mar 27.

Aspetar Orthopaedic and Sports Medicine Hospital, Doha, Qatar.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjsports-2020-102153DOI Listing

RIPC provides neuroprotection against ischemic stroke by suppressing apoptosis via the mitochondrial pathway.

Sci Rep 2020 Mar 24;10(1):5361. Epub 2020 Mar 24.

Department of Neurobiology, Preclinical Medicine Research Center, Southwest Medical University, Luzhou, 646000, China.

Ischemic stroke is a common disease with high morbidity and mortality. Remote ischemic preconditioning (RIPC) can stimulate endogenous protection mechanisms by inducing ischemic tolerance to reduce subsequent damage caused by severe or fatal ischemia to non-ischemic organs. This study was designed to assess the therapeutic properties of RIPC in ischemic stroke and to elucidate their underlying mechanisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-62336-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093414PMC

Sex differences in the response to oxidative and proteolytic stress.

Redox Biol 2020 Apr 9;31:101488. Epub 2020 Mar 9.

Molecular and Computational Biology Program, Department of Biological Sciences, Dornsife College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, CA, USA; Leonard Davis School of Gerontology, Ethel Percy Andrus Gerontology Center, University of Southern California, Los Angeles, CA90089, USA; Department of Biochemistry & Molecular Medicine, Keck School of Medicine of USC, University of Southern California, USA.

Sex differences in diseases involving oxidative and proteolytic stress are common, including greater ischemic heart disease, Parkinson disease and stroke in men, and greater Alzheimer disease in women. Sex differences are also observed in stress response of cells and tissues, where female cells are generally more resistant to heat and oxidative stress-induced cell death. Studies implicate beneficial effects of estrogen, as well as cell-autonomous effects including superior mitochondrial function and increased expression of stress response genes in female cells relative to male cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.redox.2020.101488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212483PMC

The influence of climate change on human cardiovascular function.

Arch Environ Occup Health 2020 Mar 23:1-9. Epub 2020 Mar 23.

Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, Belgrade, Serbia.

Climate change is considered to have great impact on human health. The heat waves have been associated with excess morbidity and mortality of cardiovascular diseases (CVD) across various populations and geographic locations. Important role in the heat-induced cardiovascular damage has endothelial dysfunction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/19338244.2020.1742079DOI Listing

Gadolinium labelled nanoliposomes as the platform for MRI theranostics: in vitro safety study in liver cells and macrophages.

Sci Rep 2020 Mar 16;10(1):4780. Epub 2020 Mar 16.

Veterinary Research Institute, Brno, Czech Republic.

Gadolinium (Gd)-based contrast agents are extensively used for magnetic resonance imaging (MRI). Liposomes are potential nanocarrier-based biocompatible platforms for development of new generations of MRI diagnostics. Liposomes with Gd-complexes (Gd-lip) co-encapsulated with thrombolytic agents can serve both for imaging and treatment of various pathological states including stroke. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-60284-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075985PMC

Effects of Ibuprofen during Exertional Heat Stroke in Mice.

Med Sci Sports Exerc 2020 Mar 13. Epub 2020 Mar 13.

Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL.

Intestinal injury is one of the most prominent features of organ damage in exertional heat stroke (EHS). However, whether damage to the intestine in this setting is exacerbated by ibuprofen (IBU), the most commonly used NSAID in exercising populations, is not well understood.

Purpose: We hypothesized that IBU would exacerbate intestinal injury, reduce exercise performance and increase susceptibility to heat stroke. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1249/MSS.0000000000002329DOI Listing

Therapeutic Hypothermia Protects Against Heat Stroke-Induced Arterial Hypotension via Promoting Left Ventricular Performance in Rats.

Int J Med Sci 2020 10;17(4):525-535. Epub 2020 Feb 10.

Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan 73657, Taiwan.

We aimed to ascertain whether therapeutic hypothermia (TH) acts as cardioprotective management for heat stroke (HS). Adult male rats under general anesthesia were exposed to whole-body heating (43°C for 70 min) to induce HS. Rats with HS displayed hyperthermia (core body temperature 42°C vs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.39745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053305PMC
February 2020

Beyond Heat Stress: Intestinal Integrity Disruption and Mechanism-Based Intervention Strategies.

Nutrients 2020 Mar 11;12(3). Epub 2020 Mar 11.

Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands.

The current climate changes have increased the prevalence and intensity of heat stress (HS) conditions. One of the initial consequences of HS is the impairment of the intestinal epithelial barrier integrity due to hyperthermia and hypoxia following blood repartition, which often results in a leaky gut followed by penetration and transfer of luminal antigens, endotoxins, and pathogenic bacteria. Under extreme conditions, HS may culminate in the onset of "heat stroke", a potential lethal condition if remaining untreated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu12030734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146479PMC

Advanced Artificial Electronic Skin Based pH Sensing System for Heatstroke Detection.

ACS Sens 2020 04 12;5(4):911-916. Epub 2020 Mar 12.

Micro/Nano Technology Center, Tokai University, 4-1-1 Kitakaname, Hiratsuka, Kanagawa 259-1292, Japan.

Heatstroke is a serious illness that can potentially damage many victims every year. Many intelligent physical sensors have been developed to prevent heatstroke fatalities. However, it remains a challenge to fabricate skin-adhesive, small, and low-cost sensors for heatstroke detection to overcome the weaknesses of the physical sensors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acssensors.0c00207DOI Listing

Performance of quick sequential organ failure assessment (qSOFA) score for prognosis of heat-related hospitalized patients.

Heart Lung 2020 Mar 3. Epub 2020 Mar 3.

Department of Infectious Diseases and Hepatology, The Second Hospital of Shandong University, Jinan 250033, China. Electronic address:

Background: Heat-related illnesses pose significant threats to human health.

Objectives: (1) To evaluate the use of qSOFA score for prognosis of heat-related hospitalized patients; and (2) identify other predictors for patient prognosis.

Methods: Using 28-day mortality as the primary endpoint, a retrospective, observational study of patients hospitalized between June 2013 and September 2018 was conducted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hrtlng.2020.02.040DOI Listing

Severe Acute Liver Injury Related to Heat Stroke.

Eur J Case Rep Intern Med 2020 1;7(2):001382. Epub 2020 Jan 1.

Intensive Care Department, Unidade de Saúde Local de Matosinhos, Portugal.

Heat stroke (HS) is a life-threatening condition characterized by hyperthermia and multiple organ failure. Mild to moderate hepatocellular injury is a well-documented complication but severe liver injury and acute liver failure are rare. There are neither established criteria nor optimal timing for liver transplantation and conservative management seems to be the cornerstone treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12890/2020_001382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050967PMC
January 2020

Biochemical recovery from exertional heat stroke follows a 16-day time course.

PLoS One 2020 4;15(3):e0229616. Epub 2020 Mar 4.

Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States of America.

Background: The aim of this study was to characterize the time-resolved progression of clinical laboratory disturbances days-following an exertional heat stroke (EHS). Currently, normalization of organ injury clinical biomarker values is the primary indicator of EHS recovery. However, an archetypical biochemical recovery profile following EHS has not been established. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229616PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055888PMC
March 2020
3.234 Impact Factor

The efficacy of antibiotics in reducing morbidity and mortality from heatstroke - A systematic review.

J Therm Biol 2020 Feb 3;88:102509. Epub 2020 Jan 3.

Centre for Human Performance, Exercise and Rehabilitation (CHPER), Division of Sport, Health and Exercise Sciences, Brunel University London, Kingston Lane, Uxbridge, UB8 3PH, UK. Electronic address:

Severe hyperthermia, for example, classical heatstroke or exertional heatstroke from heatwaves or exercise respectively, or from drug ingestion or other non-infective pyrogens, is associated with a high mortality and morbidity, which may be chronic or permanent. Abolition of lipopolysaccharide, from gram-negative intestinal bacteria translocating into the systemic circulation via an intestinal wall rendered permeable from the hyperthermia, reduces the adverse effects, suggesting that antibiotics against the intestinal bacteria may have a similar effect. A systematic review searching Embase, MEDLINE and PubMed from the earliest date available until 2019 was conducted, according to PRISMA guidelines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtherbio.2020.102509DOI Listing
February 2020

Significant Quantitative Differences in Orexin Neuronal Activation After Pain Assessments in an Animal Model of Sickle Cell Disease.

Front Mol Biosci 2020 31;7. Epub 2020 Jan 31.

Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, United States.

Sickle cell disease is a hemoglobinopathy that causes sickling of red blood cells, resulting in vessel blockage, stroke, anemia, inflammation, and extreme pain. The development and treatment of pain, in particular, neuropathic pain in sickle cell disease patients is poorly understood and impedes our progress toward the development of novel therapies to treat pain associated with sickle cell disease. The orexin/hypocretin system offers a novel approach to treat chronic pain and hyperalgesia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmolb.2020.00005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025496PMC
January 2020

Prognostic Factors Associating with Pro-oxidant-antioxidant Balance; Neutrophils to Lymphocytes Ratio, Vitamin D, Heat Shock Protein 27, and Red Cell Distribution Width.

Arch Med Res 2020 Apr 26;51(3):261-267. Epub 2020 Feb 26.

Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; International UNESCO Center for Health Related Basic Sciences and Human Nutrition, Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Background: Several chronic diseases are mediated by oxidative stress. Oxidative stress affects cell morphology and function and is associated with alterations in the serum protein component. In the current study, we analyzed four individual prognostic factors associating with serum Pro-Oxidant-Antioxidant Balance (PAB): neutrophil to lymphocyte ratio (NLR), Vitamin D, anti-heat shock protein 27 (anti-hsp27) antibody titer, and red blood cell distribution width (RDW) to evaluate them as the potential prognostic markers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcmed.2020.02.006DOI Listing
April 2020
2.406 Impact Factor