3,519 results match your criteria Heatstroke


Heat stress combined with lipopolysaccharide alter the activity and superficial molecules of peripheral monocytes.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419828891

1 Department of Critical Care Medicine, The Fifth Peoples' Hospital of Dongguan, Dongguan Hospital Affiliated to Jinan University, Dongguan, China.

The purpose of this study was to focus on the underlying relationship between the hyperactivity for the peripheral monocytes and heat stroke by investigating the inflammatory oxidative activity of and the expression of superficial molecules. Peripheral blood samples were collected from 10 healthy adult volunteers. Human blood monocytes were isolated by density gradient centrifugation and sequent adherent culture. Read More

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http://dx.doi.org/10.1177/2058738419828891DOI Listing
February 2019

The association between heat stroke and subsequent cardiovascular diseases.

PLoS One 2019 13;14(2):e0211386. Epub 2019 Feb 13.

Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Background: Recent studies have indicated that several critical illnesses are associated with an increased risk of cardiovascular diseases (CVDs). Nonetheless, studies of the association between heat-related illnesses (HRIs) and subsequent CVDs are still limited. We sought to evaluate whether heat stroke (HS) was associated with an increased CVD incidence. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211386PLOS
February 2019
2 Reads

The Epidemiology and Management of Exertional Heat Illnesses in High School Sports During the 2012/13-2016/17 Academic Years.

J Sport Rehabil 2019 Feb 12:1-24. Epub 2019 Feb 12.

5 Korey Stringer Institute, Department of Kinesiology, University of Connecticut, Storrs, CT.

Context:: Recent data on exertional heat illness (EHI) in high school sports is limited, yet warranted to identify specific settings with the highest risk of EHI.

Objective:: To describe the epidemiology of EHI in high school sports during the 2012/13-2016/17 academic years.

Setting:: Aggregate injury and exposure data collected from athletic trainers working in high school sports in the United States (US). Read More

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https://journals.humankinetics.com/doi/10.1123/jsr.2018-0364
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http://dx.doi.org/10.1123/jsr.2018-0364DOI Listing
February 2019
2 Reads

Is Heat Intolerance State or Trait?

Sports Med 2019 Feb 11. Epub 2019 Feb 11.

Korey Stringer Institute, Department of Kinesiology, University of Connecticut, Storrs, CT, USA.

The existing literature suggests two standpoints in defining heat intolerance, which are heat tolerance as state or trait. The former bases its case in the plasticity of human physiology, where one may gain or lose the adaptations associated with heat acclimatization and the ability to tolerate heat is considered transient. This phenomenon is exemplified in the recovery process of exertional heat stroke (EHS) patients in that victims of EHS are able to eventually regain heat tolerance and return to activity without recurrent episodes of EHS. Read More

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http://dx.doi.org/10.1007/s40279-019-01067-zDOI Listing
February 2019
1 Read

Massive intestinal liquid retention in a case of severe heat stroke.

J Paediatr Child Health 2019 Feb;55(2):248-249

Department of Pediatrics, School of Medicine Institute of Medical, Pharmaceuticaland Health Sciences Kanazawa University, Kanazawa Japan.

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http://doi.wiley.com/10.1111/jpc.14343
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http://dx.doi.org/10.1111/jpc.14343DOI Listing
February 2019
3 Reads

Radial versus femoral vascular access in ST-elevation myocardial infarction: Are the results of femoral operators unfairly represented in observational research?

Am Heart J 2019 Jan 16;210:81-87. Epub 2019 Jan 16.

Institute of Cardiovascular Medicine and Science, Liverpool Heart and Chest Hospital, Liverpool.

Background: Recent randomized controlled trials comparing femoral and radial access in primary percutaneous coronary intervention (PPCI) have shown conflicting results regarding the incidence of major adverse cardiovascular events (MACE) and major bleeding.

Methods: Using data from the HEAT-PPCI trial, we compared the primary efficacy (all-cause mortality, stroke, new myocardial infarction or unplanned repeat revascularization) and safety (major bleeding BARC 3-5) outcomes at 28 days, by final access site used (radial or femoral) and by default operator type. We then assessed outcomes in femoral cases performed by both operator types. Read More

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http://dx.doi.org/10.1016/j.ahj.2018.12.009DOI Listing
January 2019
1 Read
4.463 Impact Factor

Direct Quantification of Rapid and Efficient Single-Stroke Actuation by a Martensitic Transition in a Thermosalient Crystal.

J Am Chem Soc 2019 Feb 14. Epub 2019 Feb 14.

New York University Abu Dhabi , P.O. Box 129188, Abu Dhabi , United Arab Emirates.

Molecular dynamic crystals conveniently combine flexibility required for mechanical reconfiguration, strength for effective translation of elastic energy, and long-range order of mechanically coupled molecules for rapid conversion of disordered motion (heat) or photons (light) into ordered motion (work). By direct measurement of the actuation force generated by crystals of a thermosalient solid, here we describe the first direct quantification of the work performed and energy conversion that can be accomplished by using dynamic crystals as supramolecular actuators. Upon reversible α-to-γ phase transition, crystals of (phenylazophenyl)palladium hexafluoroacetylacetonate of submillimeter to millimeter size exert forces in the range of 1-100 mN upon longitudinal and lateral expansion. Read More

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http://dx.doi.org/10.1021/jacs.8b12752DOI Listing
February 2019

School Nurses on the Front Lines of Medicine: Emergencies Associated With Sport and Physical Activities: Part 1.

NASN Sch Nurse 2019 Feb 9:1942602X18819223. Epub 2019 Feb 9.

Professor, Departments of Emergency Medicine and Pediatrics, Penn State College of Medicine.

Illness and injury associated with sport and physical activities may occur in the school setting. Although most sport-related illness and injury in students are considered minor emergencies, life- and limb-threatening illnesses or injuries may occur, such as sudden cardiac arrest, heat stroke, status asthmaticus, catastrophic brain or cervical spine injuries, hypoglycemia, blunt chest/abdominal injuries, or extremity fractures requiring surgery. It is important for the school nurse to recognize potential life- and limb-threatening emergencies associated with sport and physical activity, to initiate stabilization of the student with life- and limb-threatening symptoms, and to triage these students to an appropriate level of care (back to the classroom, home with their guardian with follow up at their primary healthcare provider's office, or directly to the closest emergency department via emergency medical services). Read More

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http://dx.doi.org/10.1177/1942602X18819223DOI Listing
February 2019
2 Reads

Enhancement in combustion, performance, and emission characteristics of a diesel engine fueled with diesel, biodiesel, and its blends by using nanoadditive.

Authors:
Suresh Vellaiyan

Environ Sci Pollut Res Int 2019 Feb 6. Epub 2019 Feb 6.

Department of Mechanical Engineering, Haramaya Institute of Technology, Haramaya University, Dire Dawa, Ethiopia.

This article presents the results of investigations carried out to evaluate the improvement in combustion, performance, and emission characteristics of a diesel engine fueled with neat petro-diesel (PD), soybean biodiesel (SB), and 50% SB blended PD (PD50SB) by using carbon nanotube (CNT) as an additive. The acid-alkaline-based transesterification process with sodium hydroxide (NaOH) as a catalyst was applied to derive the methyl ester of SB. A mass fraction of 100 ppm CNT nanoparticle was blended with base fuels by using an ultrasonicator and the physiochemical properties were measured based on EN standards. Read More

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http://dx.doi.org/10.1007/s11356-019-04356-2DOI Listing
February 2019

Ser46 phosphorylation of p53 is an essential event in prolyl-isomerase Pin1-mediated p53-independent apoptosis in response to heat stress.

Cell Death Dis 2019 Feb 4;10(2):96. Epub 2019 Feb 4.

Academy of Orthopedics Guangdong Province, Guangzhou, China.

Heat stroke has increased in frequency worldwide in recent years and continues to have a high morbidity and mortality. Identification of the mechanisms mediating heat stoke is important and necessary. Our preliminary study revealed heat stress (HS)-induced apoptosis of vascular endothelial cells was associated with reactive oxygen species (ROS)-induced p53 translocation into mitochondria. Read More

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http://dx.doi.org/10.1038/s41419-019-1316-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362080PMC
February 2019
1 Read
5.014 Impact Factor

Illness at a Para Athletics Track and Field World Championships under hot and humid ambient conditions.

PM R 2019 Jan 28. Epub 2019 Jan 28.

Medical & Scientific Department, International Paralympic Committee, Bonn, Germany.

Background: Heat related illness, including heat exhaustion and heat stroke, is seen as a major risk for athletes with a physical impairment. With the anticipation of hot and humid conditions at the Para Athletic World Championships 2015, the incidence rate of illness was determined.

Objective: Primary: To survey the illness statistics during the 2015 Para Athletic World Championships and report on any cases of significant heat related illnesses. Read More

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http://dx.doi.org/10.1002/pmrj.12086DOI Listing
January 2019
2 Reads

Protective effect of dihydromyricetin on hyperthermia-induced apoptosis in human myelomonocytic lymphoma cells.

Apoptosis 2019 Jan 25. Epub 2019 Jan 25.

Department of Public Health, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

Dihydromyricetin (DMY) is a traditional herbal medicine, with a wide range of biological activities. Extreme hyperthermia (HT) can suppress the immune system; thus, protection of the immune system is beneficial in heat-related diseases, including heatstroke. In our study, we revealed the protective effect of DMY against HT-induced apoptosis and analysed the underlying molecular mechanisms. Read More

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http://dx.doi.org/10.1007/s10495-019-01518-yDOI Listing
January 2019
1 Read

Successful treatment for disseminated intravascular coagulation (DIC) corresponding to phenotype changes in a heat stroke patient.

J Intensive Care 2019 15;7. Epub 2019 Jan 15.

Graduate School of Medicine, Department of Emergency and Critical Care Medicine, Ehime University, Shitsukawa 454, Toon, Ehime 791-0295 Japan.

Background: Heat stroke induces coagulofibrinolytic activation, which leads to life-threatening disseminated intravascular coagulation (DIC). However, treatment strategies for DIC in heat stroke have not yet been established, and also, the time course changes in coagulofibrinolytic markers have not been thoroughly evaluated. We report a severe heat stroke case with DIC who was eventually saved by anti-DIC treatments in accordance with changes in coagulofibrinolytic markers. Read More

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http://dx.doi.org/10.1186/s40560-019-0359-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332900PMC
January 2019
3 Reads

Epidemiology of Exertional Heat Illnesses in National Collegiate Athletic Association Athletes During the 2009-2010 Through 2014-2015 Academic Years.

J Athl Train 2019 Jan 22. Epub 2019 Jan 22.

Department of Exercise and Sport Science, University of North Carolina at Chapel Hill.

Context: Exertional heat illnesses (EHIs) among football athletes have been widely researched, but data examining all collegiate sports are limited.

Objective: To describe the epidemiology of EHI in 25 National Collegiate Athletic Association (NCAA) sports.

Design: Descriptive epidemiology study. Read More

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http://dx.doi.org/10.4085/1062-6050-504-17DOI Listing
January 2019
1 Read

Liver Transplantation for Fulminant Hepatic Failure Due to Heat Stroke: A Case Report.

Transplant Proc 2019 Jan - Feb;51(1):87-89. Epub 2018 Jun 30.

Liver Transplant Unit, Department of Surgery, Hospital Clínico Universitario Virgen de la Arrixaca (Murcia)-IMIB-Arrixaca, Murcia, Spain.

Heat stroke is a condition caused by an excessive increase in body temperature in a relatively short period of time, and is clinically characterized by central nervous system dysfunction, including delirium, seizures, coma, and severe hyperthermia. In this context, the resulting fulminant hepatic failure makes liver transplant the best choice when there are no guarantees of better results with conservative treatment. We present our experience in this case, possible alternative choices, and the current role of liver transplantation in the resolution of fulminant liver failure due to heat stroke. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.03.137DOI Listing
June 2018
2 Reads

Endogenous genetic risk factor for serious heatstroke: the thermolabile phenotype of carnitine palmitoyltransferase II variant.

Acute Med Surg 2019 Jan 1;6(1):25-29. Epub 2018 Oct 1.

Division of Enzyme Chemistry Institute for Enzyme Research Tokushima University Tokushima Japan.

Aim: In serious heatstroke, elevated body temperature (>40°C) is considered the main cause of illness. Mitochondrial carnitine palmitoyltransferase II (CPT II) plays an important role in adenosine triphosphate (ATP) generation from long-chain fatty acids, and its thermolabile phenotype of polymorphisms leads to ATP production loss under high fever. Whether by heatstroke or influenza, high fever suppresses mitochondrial ATP production in patients with the thermolabile phenotype of polymorphisms. Read More

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http://dx.doi.org/10.1002/ams2.373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328901PMC
January 2019
3 Reads

[Two cases of severe occupational heat stroke].

Authors:
X C Xu J X Cao J Y Li

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Nov;36(11):872-873

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2018.11.022DOI Listing
November 2018

Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity.

Elife 2019 Jan 15;8. Epub 2019 Jan 15.

Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States.

The Transient Receptor Potential Vanilloid 1 (TRPV) channel is activated by an array of stimuli, including heat and vanilloid compounds. The TRPV1 homologues TRPV2 and TRPV3 are also activated by heat, but sensitivity to vanilloids and many other agonists is not conserved among TRPV subfamily members. It was recently discovered that four mutations in TRPV2 are sufficient to render the channel sensitive to the TRPV1-specific vanilloid agonist resiniferatoxin (RTx). Read More

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https://elifesciences.org/articles/42756
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http://dx.doi.org/10.7554/eLife.42756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333442PMC
January 2019
6 Reads

Risk of heat illness in men and women: A systematic review and meta-analysis.

Environ Res 2018 Oct 25;171:24-35. Epub 2018 Oct 25.

University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK. Electronic address:

Background: Heat illness (HI) is a growing global concern; its incidence has risen dramatically across the world in recent years. The individual factors whereby elevated core temperature produces HI are not well-understood. Given known physiological differences between men and women pertaining to temperature regulation, we hypothesized that women would be at increased risk of HI than men. Read More

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http://dx.doi.org/10.1016/j.envres.2018.10.020DOI Listing
October 2018
2 Reads

Modeling Left Atrial Flow, Energy, Blood Heating Distribution in Response to Catheter Ablation Therapy.

Front Physiol 2018 14;9:1757. Epub 2018 Dec 14.

School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.

Atrial fibrillation (AF) is a widespread cardiac arrhythmia that commonly affects the left atrium (LA), causing it to quiver instead of contracting effectively. This behavior is triggered by abnormal electrical impulses at a specific site in the atrial wall. Catheter ablation (CA) treatment consists of isolating this driver site by burning the surrounding tissue to restore sinus rhythm (SR). Read More

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http://dx.doi.org/10.3389/fphys.2018.01757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302108PMC
December 2018
1 Read

Identification of Proteins Differentially Expressed in the Striatum by Melatonin in a Middle Cerebral Artery Occlusion Rat Model-a Proteomic and Approach.

Front Neurosci 2018 10;12:888. Epub 2018 Dec 10.

Division of Applied Life Science (BK 21), College of Natural Science, Gyeongsang National University, Jinju, South Korea.

Ischemic stroke is characterized by permanent or transient obstruction of blood flow, which initiates a cascading pathological process, starting from acute ATP loss to subsequent membrane depolarization, glutamate excitotoxicity, and calcium overload. Melatonin is a potent antioxidant that exerts protective effects in different experimental stroke models. In this study, melatonin effects were demonstrated by a proteomic and approach. Read More

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http://dx.doi.org/10.3389/fnins.2018.00888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295458PMC
December 2018
3 Reads

Individual variations of the human corticospinal tract and its hand-related motor fibers using diffusion MRI tractography.

Brain Imaging Behav 2019 Jan 8. Epub 2019 Jan 8.

Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

The corticospinal tract (CST) is one of the most well studied tracts in human neuroanatomy. Its clinical significance can be demonstrated in many notable traumatic conditions and diseases such as stroke, spinal cord injury (SCI) or amyotrophic lateral sclerosis (ALS). With the advent of diffusion MRI and tractography the computational representation of the human CST in a 3D model became available. Read More

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http://link.springer.com/10.1007/s11682-018-0006-y
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http://dx.doi.org/10.1007/s11682-018-0006-yDOI Listing
January 2019
2 Reads

[Analysis on influencing factors of deaths from severe heat stroke in Shanghai, 2013-2017].

Zhonghua Yu Fang Yi Xue Za Zhi 2019 Jan;53(1):93-96

Institute of health hazard factor monitoring and control, Shanghai Municipal Center for Disease Control and Prevention/Shanghai Institutes of Preventive Medicine, Shanghai 200336, China.

To explore the related factors of death from severe heat stroke in Shanghai from 2013 to 2017. The data of 1 152 patients with severe heat stroke who were divided into survival (1 037) and death (115) groups including gender, age and heat stroke type (heat cramp, heat exhaustion, heat apoplexy and the mixed type) were collected from meteorological bureau and case report system for high temperature heat stroke in Shanghai from 2013 to 2017. Meanwhile, the meteorological data of the onset date of severe heat stroke cases were collected, including maximum temperature, minimum temperature, daily temperature, relative humidity, air pressure, precipitation and wind speed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2019.01.013DOI Listing
January 2019

Precooling, Exertional Heatstroke Risk Factors, and Postexercise Cooling Rates.

Aerosp Med Hum Perform 2019 Jan;90(1):12-17

Precooling (PC) before exercise may help prevent severe hyperthermia and exertional heatstroke (EHS). Before clinicians can advocate PC as an EHS prevention strategy, it must effectively mitigate factors associated with EHS development while not lessening the effectiveness of EHS treatment. Therefore, this study determined if PC affected rectal temperature (T), body heat storage, heart rate (HR), ratings of perceived exertion (RPE), thermal sensation, sweat rate, and postexercise cold-water immersion (CWI) T cooling rates. Read More

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http://dx.doi.org/10.3357/AMHP.5194.2019DOI Listing
January 2019
4 Reads

Molecular Adsorbent Recirculating System Support Followed by Liver Transplantation for Multiorgan Failure From Heatstroke.

Transplant Proc 2018 Dec;50(10):3516-3520

Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland.

Background: Exertional heatstroke is an extremely rare cause of fulminant hepatic failure. Maximal supportive care has failed to provide adequate survival in earlier studies. This is particularly true in cases accompanied by multiorgan failure. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.07.019DOI Listing
December 2018

Suppression of angiotensin II-induced pathological changes in heart and kidney by the caveolin-1 scaffolding domain peptide.

PLoS One 2018 21;13(12):e0207844. Epub 2018 Dec 21.

Division of Cardiology, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston, South Carolina, United States of America.

Dysregulation of the renin-angiotensin system leads to systemic hypertension and maladaptive fibrosis in various organs. We showed recently that myocardial fibrosis and the loss of cardiac function in mice with transverse aortic constriction (TAC) could be averted by treatment with the caveolin-1 scaffolding domain (CSD) peptide. Here, we used angiotensin II (AngII) infusion (2. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207844PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303044PMC
December 2018
7 Reads

Sanhuang Xiexin decoction promotes good functional outcome in acute ischemic stroke.

Brain Behav 2019 Jan 19;9(1):e01185. Epub 2018 Dec 19.

Department of Endocrinology, Guang'anmen Hospital of China, Academy of Chinese Medical Sciences, Beijing, China.

Objectives: To explore the efficiency and safety of Sanhuang Xiexin decoction in the treatment of acute ischemic stroke (AIS) patients after endovascular intervention examination.

Methods: In this prospective observational study, 121 AIS patients admitted in our hospital were enrolled from January 2012 to December 2015. They were randomly divided into two groups, 61 patients received Sanhuang Xiexin decoction + basic treatment (SX group) and 60 patients received basic treatment (control group). Read More

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http://doi.wiley.com/10.1002/brb3.1185
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http://dx.doi.org/10.1002/brb3.1185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346639PMC
January 2019
10 Reads

Cooling Rates of Hyperthermic Humans Wearing American Football Uniforms When Cold-Water Immersion Is Delayed.

J Athl Train 2018 Dec 18;53(12):1200-1205. Epub 2018 Dec 18.

School of Rehabilitation and Medical Sciences, Central Michigan University, Mount Pleasant.

Context: Treatment delays can be contributing factors in the deaths of American football athletes from exertional heat stroke. Ideally, clinicians begin cold-water immersion (CWI) to reduce rectal temperature (T) to <38.9°C within 30 minutes of collapse. Read More

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http://dx.doi.org/10.4085/1062-6050-398-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365067PMC
December 2018

Data Analytics of a Wearable Device for Heat Stroke Detection.

Sensors (Basel) 2018 Dec 9;18(12). Epub 2018 Dec 9.

Department of Electrical and Electronic Engineering, Chung Cheng Institute of Technology, National Defense University No. 75, Shiyuan Rd., Daxi District, Taoyuan City 33551, Taiwan.

When exercising in a high-temperature environment, heat stroke can cause great harm to the human body. However, runners may ignore important physiological warnings and are not usually aware that a heat stroke is occurring. To solve this problem, this study evaluates a runner's risk of heat stroke injury by using a wearable heat stroke detection device (WHDD), which we developed previously. Read More

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http://dx.doi.org/10.3390/s18124347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308959PMC
December 2018

Response of regulatory T cells to classic heat stroke in mice.

Exp Ther Med 2018 Dec 19;16(6):4609-4615. Epub 2018 Sep 19.

Critical Care Medicine, Chinese PLA General Hospital, Beijing 100853, P.R. China.

Systemic inflammatory response syndrome (SIRS) is an important process associated with the pathogenesis of multiple organ failure resulting from heat stroke (HS). Alterations in the levels of circulating cytokines during the progression of SIRS have been well established. However, only a small number of studies have demonstrated the responses of lymphocytes during HS, and no studies have investigated immune-regulatory cells, such as regulatory T cells (Tregs). Read More

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http://www.spandidos-publications.com/10.3892/etm.2018.6766
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http://dx.doi.org/10.3892/etm.2018.6766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257472PMC
December 2018
5 Reads

Liver transplantation in patients with liver failure related to exertional heatstroke.

J Hepatol 2018 Dec 4. Epub 2018 Dec 4.

AP-HP Hôpital Paul-Brousse, Centre Hépato-Biliaire, Liver Intensive Care Unit, Villejuif F-94800, France; INSERM, Unité 1193, Université Paris-Saclay, Villejuif F-94800, France; DHU Hepatinov, Villejuif F-94800, France.

Background & Aims: Severe acute liver injury is a grave complication of exertional heatstroke. Liver transplantation (LT) may be a therapeutic option, but the criteria for LT and the optimal timing of LT have not been clearly established. The aim of this study was to define the profile of patients who require transplantation in this context. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688278183257
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http://dx.doi.org/10.1016/j.jhep.2018.11.024DOI Listing
December 2018
22 Reads

Electrophysiology in diagnosis and management of neuropathic pain.

Rev Neurol (Paris) 2019 Jan - Feb;175(1-2):26-37. Epub 2018 Oct 26.

Inserm U1028, CNRS, UMR5292, central integration of pain (NeuroPain) Lab - Lyon neuroscience research center, université Claude Bernard, 69677 Bron, France; Department of Clinical Neurophysiology, Neurological Institute, Faculty of Medicine, Graduate School of Medical Science, Kyushu University, Fukuoka, 812-8582, Japan.

Electrophysiological techniques demonstrate abnormalities in somatosensory transmission, hence providing objective evidence of 'somatosensory lesion or disease' which is crucial to the diagnosis of neuropathic pain (NP). Since most instances of NP result from damage to thermo-nociceptive pathways (thin fibres and spino-thalamo-cortical systems), specific activation of these is critical to ensure diagnostic accuracy. This is currently achieved using laser pulses or contact heat stimuli, and in a near future probably also with contact cold and intra-epidermal low-intensity currents. Read More

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http://dx.doi.org/10.1016/j.neurol.2018.09.015DOI Listing
October 2018
2 Reads

Dexmedetomidine Attenuates Acute Lung Injury Induced by Heatstroke and Improve Outcome.

Shock 2018 Nov 20. Epub 2018 Nov 20.

The Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, P. R. China.

Introduction: Dexmedetomidine (DEX) has been demonstrated to inhibit inflammatory response and protect against multiorgan injury in various scenarios. The objectives of the present study was to ascertain whether DEX is able to attenuate acute lung injury (ALI) under heatstroke (HS), and to explore the underlying mechanism.

Methods: Male C57BL/6 mice were exposed to ambient temperature of 39. Read More

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http://Insights.ovid.com/crossref?an=00024382-900000000-9771
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http://dx.doi.org/10.1097/SHK.0000000000001289DOI Listing
November 2018
9 Reads

Simultaneous infrared thermal imaging and laser speckle imaging of brain temperature and cerebral blood flow in rats.

J Biomed Opt 2018 Nov;24(3):1-11

Kyoto University, Research and Educational Unit of Leaders for Integrated Medical System, Center for, Japan.

Infrared thermal imaging of brain temperature changes is useful for evaluating cortical activity and disease states, such as stroke. However, the changes depend on a balance between changes in heat generation from metabolism and in heat convection related to blood flow. To discriminate between these effects and gain a clearer understanding of neurovascular metabolic coupling, brain temperature imaging must be improved to measure temperature and blood flow simultaneously. Read More

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http://dx.doi.org/10.1117/1.JBO.24.3.031014DOI Listing
November 2018
1 Read

An experimental investigation of performance and emission of thumba biodiesel using butanol as an additive in an IDI CI engine and analysis of results using multi-objective fuzzy-based genetic algorithm.

Environ Sci Pollut Res Int 2019 Jan 21;26(3):2281-2296. Epub 2018 Nov 21.

Department of Production Engineering, National Institute of Technology Agartala, Tripura, 799046, India.

The present work studies the effect of butanol in thumba (Citrullus colocynthis) biodiesel in an IDI CI engine at varying percentages of 5 and 10% in 15 and 10% thumba biodiesel respectively with 80% diesel in each blend. Another blend was introduced with 80% diesel and 20% biodiesel without any additive. The experiment was conducted in a single cylinder four-stroke IDI CI engine at 1500 rpm varying from 25% to full-load (100%) conditions. Read More

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http://dx.doi.org/10.1007/s11356-018-3699-yDOI Listing
January 2019
2 Reads

Heatstroke.

Handb Clin Neurol 2018 ;157:531-545

Intensive Care Unit and Experimental Medicine Department, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia. Electronic address:

Heatstroke is an acute medical emergency that is always fatal if left untreated. The diagnosis of heatstroke should be considered in any hyperthermic patient with altered mental status during a heat wave or following vigorous muscle exertion. Heat can damage the structure and function of essential macromolecules, including proteins, membrane lipids, and nucleic acids, and thereby lead to multiple-organ failure, culminating in death. Read More

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http://dx.doi.org/10.1016/B978-0-444-64074-1.00032-XDOI Listing
January 2018
7 Reads

Heat exhaustion.

Handb Clin Neurol 2018 ;157:505-529

Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada; Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba City, Japan.

Heat exhaustion is part of a spectrum of heat-related illnesses that can affect all individuals, although children, older adults, and those with chronic disease are particularly vulnerable due to their impaired ability to dissipate heat. If left uninterrupted, there can be progression of symptoms to heatstroke, a life-threatening emergency. Signs and symptoms of heat exhaustion may develop suddenly or over time. Read More

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http://dx.doi.org/10.1016/B978-0-444-64074-1.00031-8DOI Listing
January 2018
1 Read

Pyroptosis of HUVECs can be induced by heat stroke.

Biochem Biophys Res Commun 2018 Nov 24;506(3):626-631. Epub 2018 Oct 24.

The First School of Clinical Medicine, Southern Medical University, Guangzhou, China; Department of Intensive Care Unit, General Hospital of Guangzhou Military Command, Key Laboratory of Tropical Trauma Care and Tissue Repair of PLA, Guangzhou, China. Electronic address:

Heat stroke is a serious pathological condition with high mortality. Vascular endothelial cell injury is a key feature in the pathogenesis of heat stroke, but the specific pathophysiological process whereby this occurs is still unclear. Currently, relevant studies are primarily based upon examination of apoptosis. Read More

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http://dx.doi.org/10.1016/j.bbrc.2018.10.051DOI Listing
November 2018
16 Reads

Interactions between body fluid homeostasis and thermoregulation in humans.

Handb Clin Neurol 2018 ;156:417-429

Department of Sports Medical Sciences, Shinshu University Graduate School of Medicine, Institute for Biomedical Sciences, Shinshu University, Matsumoto, Japan.

Humans are unique in their ability to control body temperature with a large amount of skin blood flow and sweat rate while exercising in an upright position. However, cutaneous vasodilation in the body reduces total peripheral resistance and blood pooling in cutaneous veins decreases venous return to the heart and cardiac filling pressure. In addition, hypovolemia by sweating accelerates the reduction in cardiac filling pressure. Read More

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http://dx.doi.org/10.1016/B978-0-444-63912-7.00025-4DOI Listing
January 2018
9 Reads

Bone marrow-derived mononuclear cell therapy can attenuate systemic inflammation in rat heatstroke.

Scand J Trauma Resusc Emerg Med 2018 Nov 16;26(1):97. Epub 2018 Nov 16.

Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, 2-15 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Background: This study was performed to gain insights into novel therapeutic approaches for acute systemic inflammation in heatstroke. Bone marrow-derived mononuclear cells (BMMNCs) secrete anti-inflammatory proteins and have protective effects against acute inflammation. Recent evidence suggested that transplantation of BMMNCs can reduce the acute tissue injury caused by regional myocardial reperfusion and the lung dysfunction induced by lipopolysaccharides. Read More

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https://sjtrem.biomedcentral.com/articles/10.1186/s13049-018
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http://dx.doi.org/10.1186/s13049-018-0566-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240199PMC
November 2018
12 Reads

A combined banding method that allows the reliable identification of chromosomes as well as differentiation of AT- and GC-rich heterochromatin.

Chromosome Res 2018 Dec 15;26(4):307-315. Epub 2018 Nov 15.

Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Russia.

Сonstitutive heterochromatin areas are revealed by differential staining as C-positive chromosomal regions. These C-positive bands may greatly vary by location, size, and nucleotide composition. CBG-banding is the most commonly used method to detect structural heterochromatin in animals. Read More

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http://link.springer.com/10.1007/s10577-018-9589-9
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http://dx.doi.org/10.1007/s10577-018-9589-9DOI Listing
December 2018
8 Reads

[Advances in pre-hospital recognition and cooling treatment of exertional heat stroke].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Oct;30(10):1006-1010

Department of ICU, No.401 Hospital of the People's Liberation Army, Qingdao 266071, Shandong, China. Corresponding author: Li Hailing, Email:

Objective: Heat stroke (HS) is a life-threatening illness characterized by an altered level of consciousness with an elevated core body temperature 40 centigrade, which may be further classified as exertional heat stroke (EHS) or classical heat stroke (CHS) according to the etiology of the condition. In recent years, the morbidity of EHS increases year by year. The severity and clinical outcome for an EHS casualty have a strong correlation with the area under the time and temperature curve for heat exposure. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2018.010.021DOI Listing
October 2018
2 Reads

Multiple Patients With Heatstroke Air Evacuated by Agreement Concerning Collaboration.

Air Med J 2018 Nov - Dec;37(6):388-391. Epub 2018 Sep 3.

Department of Acute Critical Care Medicine, Shizuoka Hospital, Juntendo University, Shizouka, Japan. Electronic address:

On August 30, 2017, the wet-bulb globe temperature was 30°C. Three female military personnel fell unconscious almost simultaneously around noon after a long-distance march that had started at 6 am. The fire department in Gotenba received a 119 call [at 1:16 PM] and requested dispatch of the eastern Shizuoka doctor helicopter (DH) because it would take about 1 hour from the scene to arrive at our hospital by ground ambulance. Read More

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http://dx.doi.org/10.1016/j.amj.2018.07.026DOI Listing
September 2018
3 Reads

Very Delayed Remote Ischemic Post-conditioning Induces Sustained Neurological Recovery by Mechanisms Involving Enhanced Angioneurogenesis and Peripheral Immunosuppression Reversal.

Front Cell Neurosci 2018 29;12:383. Epub 2018 Oct 29.

Department of Neurology, University Duisburg-Essen Medical School, Essen, Germany.

Ischemic conditioning is defined as a transient and subcritical period of ischemia integrated in an experimental paradigm that involves a stimulus of injurious ischemia, activating endogenous tissue repair mechanisms that lead to cellular protection under pathological conditions like stroke. Whereas ischemic pre-conditioning is irrelevant for stroke treatment, ischemic post-conditioning, and especially non-invasive remote ischemic post-conditioning (rPostC) is an innovative and potential strategy for stroke treatment. Although rPostC has been shown to induce neuroprotection in stroke models before, resulting in some clinical trials on the way, fundamental questions with regard to its therapeutic time frame and its underlying mechanisms remain elusive. Read More

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https://www.frontiersin.org/article/10.3389/fncel.2018.00383
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http://dx.doi.org/10.3389/fncel.2018.00383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216109PMC
October 2018
15 Reads

Calpain-2 protects against heat stress-induced cardiomyocyte apoptosis and heart dysfunction by blocking p38 mitogen-activated protein kinase activation.

J Cell Physiol 2018 Nov 11. Epub 2018 Nov 11.

Department of Medicine, Critical Illness Research Center, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada.

Cardiovascular dysfunction is a common complication among heatstroke patients, but its underlying mechanism is unclear. This study was designed to investigate the role of calpain-2 and its downstream signal pathway in heat stress-induced cardiomyocyte apoptosis and heart dysfunction. In cultured primary mouse neonatal cardiomyocytes (MNCs), heat stress (43°C for 2 hr) induced a heat-shock response, as indicated by upregulated heat-shock protein 27 (HSP27) expression and cellular apoptosis, as indicated by increased caspase-3 activity, DNA fragmentation and decreased cell viability. Read More

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http://dx.doi.org/10.1002/jcp.27750DOI Listing
November 2018
2 Reads

Determining Maximum Sublimation Rate for a Production Lyophilizer: Computational Modeling and Comparison With Ice Slab Tests.

J Pharm Sci 2019 Jan 8;108(1):382-390. Epub 2018 Nov 8.

School of Aeronautics and Astronautics, Purdue University, West Lafayette, Indiana 47907. Electronic address:

Equipment capability is an important factor in scale up and technology transfer for lyophilized pharmaceutical products. Experimental determination of equipment capability limits, such as the maximum sublimation rate at a given chamber pressure, is time-intensive for production lyophilizers. Here, we present computational fluid dynamics modeling of equipment capability and compare it with experimental data for minimum controllable pressure ice slab sublimation tests in a 23 m shelf area freeze dryer. Read More

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http://dx.doi.org/10.1016/j.xphs.2018.10.061DOI Listing
January 2019
2 Reads

Physiological, biochemical and histopathological changes associated with heatstroke in the Galah (Eolophus roseicapilla) and Rock Dove (Columba livia).

Avian Pathol 2018 Nov 9:1-49. Epub 2018 Nov 9.

b School of Animal & Veterinary Sciences , University of Adelaide , Roseworthy Campus, SA 5371 Australia.

The pathophysiology of heat illnesses in birds has not been well characterised. In this study, we describe the changes in heart rate, respiratory rate, blood biochemistry and histopathological findings in galahs and rock doves after heat exposure under standardized conditions designed to induce heatstroke. Birds in the heat exposed group were exposed to environmental heat stress and compared to control birds. Read More

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https://www.tandfonline.com/doi/full/10.1080/03079457.2018.1
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http://dx.doi.org/10.1080/03079457.2018.1546824DOI Listing
November 2018
7 Reads

Differential Expression Pattern of Exosome Long Non-Coding RNAs (lncRNAs) and MicroRNAs (miRNAs) in Vascular Endothelial Cells Under Heat Stroke.

Med Sci Monit 2018 Nov 6;24:7965-7974. Epub 2018 Nov 6.

Department of Critical Care Medicine, Guangzhou School of Clinical Medicine, Southern Medical University (Guangzhou General Hospital of Guangzhou Military Region), Guangzhou, Guangdong, China (mainland).

BACKGROUND Heat stroke is a life-threatening disease which is characterized by a high body temperature and multiple organ dysfunction syndrome. Vascular endothelial cell injury is a main feature of heat stroke. Little is known about the long noncoding RNA (lncRNA) and microRNA (miRNA) expression alternation in endothelial cell exosomes related to heat stroke. Read More

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https://www.medscimonit.com/abstract/index/idArt/909983
Publisher Site
http://dx.doi.org/10.12659/MSM.909983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234752PMC
November 2018
17 Reads