4,287 results match your criteria Heatstroke

The effect of acute intradermal administration of ascorbate on heat loss responses in older adults with uncomplicated controlled hypertension.

Exp Physiol 2022 May 21. Epub 2022 May 21.

Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Canada.

New Findings: What is the central question of this study? Does acute intradermal administration of the antioxidant ascorbate augment local forearm cutaneous vasodilatation and sweating via nitric oxide synthase (NOS)-dependent mechanisms during exercise-heat stress in older adults with uncomplicated controlled hypertension? What is the main finding and its importance? Relative to control site, ascorbate had no effect on forearm cutaneous vascular conductance (CVC) and sweat rate, although CVC was reduced with NOS-inhibition in older adults with hypertension. We showed that acute local administration of ascorbate to forearm skin does not modulate heat loss responses during exercise-heat stress in older adults with hypertension.

Abstract: Nitric oxide synthase (NOS) contributes to the heat loss responses of cutaneous vasodilatation and sweating during exercise. Read More

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Anti-Inflammatory and Anti-Oxidative Effects of Isorhamnetin for Protection Against Lung Injury in a Rat Model of Heatstroke in a Dry-Heat Environment.

Med Sci Monit 2022 May 19;28:e935426. Epub 2022 May 19.

Key Laboratory of The Special Environmental Medicine of Xinjiang, General Hospital of Xinjiang Military Command of The Chinese People's Liberation Army (PLA), Urumqi, Xinjiang, China (mainland).

BACKGROUND Isorhamnetin is a natural flavonoid compound with anti-inflammatory and antioxidant properties. However, its roles in alleviating lung injury associated with heatstroke remain unclear. Therefore, this study aimed to evaluate the protective effects of different isorhamnetin doses on lung injury in heatstroke rat models exposed to a dry-heat environment. Read More

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Spatial Pattern and Land Surface Features Associated with Cloud-to-Ground Lightning in Bangladesh: An Exploratory Study.

Earth Syst Environ 2022 May 12:1-15. Epub 2022 May 12.

School of Design and Built Environment, Curtin University, Kent Street, Bentley, Perth, Western Australia 6102 Australia.

Severe weather events such as lightning appear to be a significant threat to humans and property in South Asia, an area known for intense convective activity directly related to the tropical climate of these areas. The current study was conducted in Bangladesh and examined the association between cloud-to-ground (CG) lightning and ground surface properties, with the aim of improving existing knowledge regarding this phenomenon. GLD360 data from 2015 to 2020 were used to describe the seasonal lightning climatology. Read More

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A Case Report of Subcutaneously Injected Liposomal Cannabidiol Formulation Used as a Compassion Therapy for Pain Management in a Dog.

Front Vet Sci 2022 28;9:892306. Epub 2022 Apr 28.

Laboratory of Membrane and Liposome Research, Department of Biochemistry, Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel.

A 14-year-old intact mixed breed dog (26 kg) was submitted for a novel cannabidiol (CBD) analgesic treatment. The dog was cachectic and had a testicular neoplasia, hip and elbow osteoarthritis and severe cervical pain. Analgesic treatment included canine osteoarthritic supplement, robencoxib and gabapentin. Read More

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Novel Use of Seraph-100™ Blood Purification Therapy in Heat Stroke.

Mil Med 2022 May 16. Epub 2022 May 16.

Internal Medicine, Madigan Army Medical Center, Tacoma, WA 98430, USA.

The Seraph-100™ is a purification filter that blunts cytokine storm, providing a more favorable environment to establish immune homeostasis. We present a novel case of compassionate use of Seraph filter in a young, healthy active duty service member with heat injury-induced massive inflammatory response. The patient is a previously healthy 26-year-old male with altered mental status, tachycardia, fever to 40. Read More

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Global Warming and Its Implications on Nature Tourism at Phinda Private Game Reserve, South Africa.

Int J Environ Res Public Health 2022 Apr 30;19(9). Epub 2022 Apr 30.

Department of Tourism and Integrated Communication, Vaal University of Technology 1, Vanderbijlpark 1900, South Africa.

The past decade recorded the highest number of high impact extreme weather events such as flooding, rainfall events, fires, droughts, and heatwaves amongst others. One of the key features and drivers of extreme weather events has been global warming, with record temperatures recorded globally. The World Meteorological Organization indicated that the 2010-2020 decade was one of the warmest on record. Read More

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High-Fat Diet Impairs Muscle Function and Increases the Risk of Environmental Heatstroke in Mice.

Int J Mol Sci 2022 May 9;23(9). Epub 2022 May 9.

CAST, Center for Advanced Studies and Technology, University G. D'Annunzio of Chieti-Pescara, 66100 Chieti, Italy.

Environmental heat-stroke (HS) is a life-threatening response often triggered by hot and humid weather. Several lines of evidence indicate that HS is caused by excessive heat production in skeletal muscle, which in turn is the result of abnormal Ca leak from the sarcoplasmic reticulum (SR) and excessive production of oxidative species of oxygen and nitrogen. As a high fat diet is known to increase oxidative stress, the objective of the present study was to investigate the effects of 3 months of high-fat diet (HFD) on the HS susceptibility of wild type (WT) mice. Read More

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Experimental study on the protective mechanism of mesenchymal stem cells against central nervous system injury in heat stroke.

Curr Stem Cell Res Ther 2022 May 11. Epub 2022 May 11.

Department of Critical Care Medicine, Chinese PLA General Hospital, Beijing 100853, China.

Background: Heat stroke (HS) is a serious disease accompany with central nervous system (CNS) injury, such as delirium, convulsion, and coma. Currently, mesenchymal stem cells (MSCs) have been demonstrated novel neuroprotective effects, and thereofre it becomes the aim of the present research to explore the neuroprotective effects and mechanisms of MSCs against HS injury.

Methods: HS rat models were induced in a 40℃ and 65% humidity environment until the rectal temperature reached to 42℃. Read More

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Athlete Medical Services at the Marathon and Race Walking Events During Tokyo 2020 Olympics.

Front Sports Act Living 2022 22;4:872475. Epub 2022 Apr 22.

Faculty of Sport Sciences, Waseda University, Saitama, Japan.

Epidemiological data from race walk and marathon events suggest that a high incidence rate of exertional heat illness is associated with high ambient temperature and relative humidity. The 2020 Summer Olympics in Tokyo was no exception, which led the organizing committee to relocate the race walk and marathon competitions to Sapporo, which was predicted to experience much milder heat. Nonetheless, during the Games, Sapporo recorded the highest daytime ambient temperature in the past 97 years, with consecutive days over 30°C from July 22nd to August 7th, 2021. Read More

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Dissecting central post-stroke pain: a controlled symptom-psychophysical characterization.

Brain Commun 2022 5;4(3):fcac090. Epub 2022 Apr 5.

Pain Center, Discipline of Neurosurgery HC-FMUSP, LIM-62, University of São Paulo, São Paulo, Brazil.

Central post-stroke pain affects up to 12% of stroke survivors and is notoriously refractory to treatment. However, stroke patients often suffer from other types of pain of non-neuropathic nature (musculoskeletal, inflammatory, complex regional) and no head-to-head comparison of their respective clinical and somatosensory profiles has been performed so far. We compared 39 patients with definite central neuropathic post-stroke pain with two matched control groups: 32 patients with exclusively non-neuropathic pain developed after stroke and 31 stroke patients not complaining of pain. Read More

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Exertional heat stroke: nutritional considerations.

Exp Physiol 2022 May 6. Epub 2022 May 6.

School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.

New Findings: What is the topic of this review? The potential role of nutrition in exertional heat stroke. What advances does it highlight? Certain nutritional and dietary strategies used by athletes and workers may exert a protective effect the pathophysiological processes of exertional heat stroke, whereas others may be detrimental. While current evidence suggests that some of these practices may be leveraged as a potential countermeasure to exertional heat stroke, further research on injury-related outcomes in humans is required. Read More

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Z-DNA binding protein 1 promotes heatstroke-induced cell death.

Science 2022 05 5;376(6593):609-615. Epub 2022 May 5.

Department of Critical Care Medicine and Hematology, The 3rd Xiangya Hospital, Central South University, Changsha 410000, P.R. China.

Heatstroke is a heat stress-induced, life-threatening condition associated with circulatory failure and multiple organ dysfunctions. If global warming continues, heatstroke might become a more prominent cause of mortality worldwide, but its pathogenic mechanism is not well understood. We found that Z-DNA binding protein 1 (ZBP1), a Z-nucleic acid receptor, mediated heatstroke by triggering receptor-interacting protein kinase 3 (RIPK3)-dependent cell death. Read More

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Early biomarkers for kidney injury in heat-related illness patients: a prospective observational study at Japanese Self-Defense Force Fuji Hospital.

Nephrol Dial Transplant 2022 May 2. Epub 2022 May 2.

Department of Nephrology and Endocrinology, National Defense Medical College, Tokorozawa, Saitama, Japan.

Background: Since heatstroke-induced acute kidney injury (AKI) can progress to chronic kidney disease, it would be useful to detect heatstroke-induced AKI and severe heat-related illness in the early phase. We studied the epidemiology of heat-related illness among patients in the Japanese Ground Self-Defense Force and evaluated the relationship between heat-related illness severity and early urinary biomarkers for AKI.

Methods: We enrolled patients who were diagnosed with heat-related illness at Self-Defense Force Fuji Hospital from May 1 to September 30, 2020. Read More

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FoxO1 Silencing Facilitates Neurological Function Recovery in Intracerebral Hemorrhage Mice via the lncRNA GAS5/miR-378a-5p/Hspa5 Axis.

J Stroke Cerebrovasc Dis 2022 Jul 26;31(7):106443. Epub 2022 Apr 26.

Interventional Diagnosis and Treatment Department, The People's Hospital of Kaizhou District, No. 233 Kaizhou Avenue (Middle), Hanfeng Street, Kaizhou District, Chongqing 405400, China. Electronic address:

Objective: Intracerebral hemorrhage (ICH) is the most devastating stroke subtype. Transcription factor Forkhead box O1 (FoxO1) is extensively implicated in cerebral injury. This study investigated the mechanism of FoxO1 in neurological function recovery in ICH mice. Read More

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Cost-effectiveness of Direct Oral Anticoagulant vs. Warfarin Among Atrial Fibrillation Patients With Intermediate Stroke Risk.

Front Cardiovasc Med 2022 11;9:849474. Epub 2022 Apr 11.

Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University, Seoul, South Korea.

Background: Several studies have shown the cost-effectiveness of direct oral anticoagulants (DOACs), compared with warfarin, to prevent atrial fibrillation (AF) related complications. However, few have reported cost-effectiveness of DOACs in AF patients with intermediate stroke risk. Thus, we investigated the cost-effectiveness of DOACs vs. Read More

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Complement Activation in Patients With Heat-Related Illnesses: Soluble CD59 Is a Novel Biomarker Indicating Severity of Heat-Related Illnesses.

Crit Care Explor 2022 Apr 21;4(4):e0678. Epub 2022 Apr 21.

Department of Emergency and Critical Care Medicine, Juntendo University Urayasu Hospital, Urayasu, Japan.

Objectives: Although multiple organ dysfunction syndrome (MODS) is the main cause of death in patients with heat-related illnesses, its underlying pathophysiological mechanism remains elusive. Complement activation is considered one of the main causes of MODS in patients with sepsis and trauma. Considering the pathophysiological similarity of heat related-illnesses with sepsis and trauma, the complement system might be activated in patients with heat-related illnesses as well. Read More

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Thromboelastography maximum amplitude as an early predictor of disseminated intravascular coagulation in patients with heatstroke.

Int J Hyperthermia 2022 ;39(1):605-610

Department of Critical Care Medicine, the 908th Hospital of Chinese Logistical Support Force, Nanchang, China.

Objectives: The aim of this study was to investigate the ability of TEG to predict DIC associated with heatstroke.

Methods: We carried out a retrospective, single-center study of 67 patients with heatstroke admitted to an intensive care unit (ICU) at a comprehensive hospital between July 2016 and August 2021. Conventional coagulation tests (CCTs) and TEG were performed within 2 h of admission in ICU. Read More

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Assessing Molecular Regulation of Vascular Permeability Using a VEGF-Inducible Zebrafish Model.

Luke H Hoeppner

Methods Mol Biol 2022 ;2475:339-350

The Hormel Institute, University of Minnesota, Austin, MN, USA.

Vascular endothelial growth factor (VEGF) stimulates vascular permeability in a variety of human pathologies, such as cancer, ischemic stroke, cardiovascular disease, retinal conditions, and COVID-19-associated pulmonary edema, sepsis, acute lung injury, and acute respiratory distress syndrome. Comprehensive investigation of the molecular mechanisms of VEGF-induced vascular permeability has been hindered by the lack of in vivo models that easily facilitate genetic manipulation studies in real time. To address this need, we generated a heat-inducible VEGF transgenic zebrafish model of vascular permeability. Read More

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Advancements in left ventricular assist devices to prevent pump thrombosis and blood coagulopathy.

J Anat 2022 Apr 20. Epub 2022 Apr 20.

Tissue Engineering Research Group (TERG), Department of Anatomy and Regenerative Medicine, RCSI University of Medicine and Health Sciences, Dublin 2, Dublin, Ireland.

Mechanical circulatory support (MCS) devices, such as left ventricular assist devices (LVADs) are very useful in improving outcomes in patients with advanced-stage heart failure. Despite recent advances in LVAD development, pump thrombosis is one of the most severe adverse events caused by LVADs. The contact of blood with artificial materials of LVAD pumps and cannulas triggers the coagulation cascade. Read More

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A mouse model of exertional heatstroke-related acute kidney injury.

Ann Transl Med 2022 Mar;10(6):276

Department of Critical Care Medicine, The First Medical Centre, Chinese People's Liberation Army General Hospital, Beijing, China.

Background: Acute kidney injury (AKI) is a common complication of exertional heat stroke (EHS) with a complex pathogenesis. We established a stable mouse model of EHS-related AKI (EHS-AKI).

Methods: C57BL/6 male mice were divided into 6 groups: Saline Control group, Glycerol Control group, Saline + Sham heat exercise (SHE) group, Saline + Heat exercise (HE) group, Glycerol + SHE group, and Glycerol + HE group. Read More

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Immune Cells Characteristics and Their Prognostic Effects in Exertional Heatstroke Patients: A Retrospective Cohort Study.

Front Med (Lausanne) 2022 1;9:867774. Epub 2022 Apr 1.

Department of Critical Care Medicine, General Hospital of Southern Theater Command of PLA, Guangzhou, China.

Background: Exertional heatstroke (EHS) remains a major problem for those who take strenuous physical activity. Inflammation and immune dysfunction were thought to be crucial to the pathophysiological process of heatstroke. The present study was aimed to investigate the dynamic changes of the immune cells in patients with EHS and determine their prognostic effects to provide the clinical evidence of the above process. Read More

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Climatic influences on cardiovascular diseases.

World J Cardiol 2022 Mar;14(3):152-169

School of Medicine, University of Bologna, Bologna 40126, Italy.

Classical risk factors only partially account for variations in cardiovascular disease incidence; therefore, also other so far unknown features, among which meteorological factors, may influence heart diseases (mainly coronary heart diseases, but also heart failure, arrhythmias, aortic dissection and stroke) rates. The most studied phenomenon is ambient temperature. The relation between mortality, as well as cardiovascular diseases incidence, and temperature appears graphically as a ''U'' shape. Read More

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In Silico Identification and Mechanism Exploration of Active Ingredients against Stroke from An-Gong-Niu-Huang-Wan (AGNHW) Formula.

Oxid Med Cell Longev 2022 5;2022:5218993. Epub 2022 Apr 5.

Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.

An-Gong-Niu-Huang-Wan (AGNHW) is a well-known formula for treating cerebrovascular diseases, with roles including clearing away heat, detoxification, and wake-up consciousness. In recent years, AGNHW has been commonly used for the treatment of ischemic stroke, but the mechanism by which AGNHW relieves stroke has not been clearly elucidated. In the current study, we developed a multiple systems pharmacology-based framework to identify the potential antistroke ingredients in AGNHW and explore the underlying mechanisms of action (MOA) of AGNHW against stroke from a holistic perspective. Read More

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Catheter ablation for persistent atrial fibrillation with left ventricular systolic dysfunction: Who is the best candidate?

Pacing Clin Electrophysiol 2022 May 22;45(5):629-638. Epub 2022 Apr 22.

Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Background: Tachycardia-induced cardiomyopathy is poorly recognized pre-ablation. It remains unclear of better patient selection and timing for catheter ablation in persistent atrial fibrillation (PerAF) with heart failure (HF).

Methods: Consecutive patients with PerAF and left ventricular ejection fraction (LVEF) <50% referred for AF ablation were retrospectively included. Read More

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Cold allodynia is correlated to paroxysmal and evoked mechanical pain in complex regional pain syndrome (CRPS).

Scand J Pain 2022 Apr 18. Epub 2022 Apr 18.

Section of Clinical Neurophysiology, Department of Neurology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

Objectives: Mechanisms of complex regional pain syndrome (CRPS) are still debated. Identifying subgroups of patients have been attempted in the hope of linking clinical findings to possible mechanisms. The aim of the present study was to investigate whether subgroups of CRPS (based on quantitative sensory testing (QST)-results) differed with respect to different characteristics of pain like spontaneous ongoing or paroxysmal pain and mechanical dynamic allodynia. Read More

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Performance and environmental impact assessment of diesel engine operating on high viscous punnai oil-diesel blends.

Environ Sci Pollut Res Int 2022 Apr 14. Epub 2022 Apr 14.

Department of Automobile Engineering, Jain University, Bengaluru, Karnataka, India.

The increasing demand for energy consumption because of the growing population and environmental concerns has motivated the researchers to ponder about alternative fuel that could replace diesel fuel. A new fuel should be cheaply available, clean, efficient, and environmentally friendly. In this paper, the engine operated with neat punnai oil blends with diesel was investigated at various engine load conditions, keeping neat punnai oil and diesel as base fuels. Read More

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Malignant Hyperthermia: A Killer If Ignored.

J Perianesth Nurs 2022 Apr 9. Epub 2022 Apr 9.

Oral and Maxillofacial Surgery Department, Xiangya Stomatology Hospital, Central South University, Changsha, Hunan, China. Electronic address:

Malignant hypothermia (MH) is a potentially fatal hypermetabolic reaction of skeletal muscle. It is an autosomal dominant disorder that generally occurs in people with RYR1, CACNA1S, or STAC3 mutations. And these genetic abnormalities often cause the imperfection of calcium release channels of skeletal muscle. Read More

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Epigenetic responses to heat: From adaptation to maladaptation.

Exp Physiol 2022 Apr 12. Epub 2022 Apr 12.

Laboratory of Environmental Physiology, Faculty of Dentistry, The Hebrew University of Jerusalem, Jerusalem, Israel.

New Findings: What is the topic of this review? This review outlines the history of research on epigenetic adaptations to heat exposure. The perspective taken is that adaptations reflect properties of hormesis, whereby low, repeated doses of heat induce adaptation (acclimation/acclimatization); whereas brief, life-threatening exposures can induce maladaptive responses. What advances does it highlight? The epigenetic mechanisms underlying acclimation/acclimatization comprise specific molecular programmes on histones that regulate heat shock proteins transcriptionally and protect the organism from subsequent heat exposures, even after long delays. Read More

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Store-Operated Ca Entry in Skeletal Muscle Contributes to the Increase in Body Temperature during Exertional Stress.

Int J Mol Sci 2022 Mar 29;23(7). Epub 2022 Mar 29.

CAST, Center for Advanced Studies and Technology & DMSI, Department of Medicine and Aging Sciences, University G. d'Annunzio of Chieti-Pescara, 66100 Chieti, Italy.

Exertional heat stroke (HS) is a hyperthermic crisis triggered by an excessive accumulation of Ca in skeletal muscle fibers. We demonstrated that exercise leads to the formation of calcium entry units (CEUs), which are intracellular junctions that reduce muscle fatigue by promoting the recovery of extracellular Ca via store-operated Ca entry (SOCE). Here, we tested the hypothesis that exercise-induced assembly of CEUs may increase the risk of HS when physical activity is performed in adverse environmental conditions (high temperature and humidity). Read More

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Impact of compression ratio on combustion, performance and exhaust emissions of diesel engine fueled with Undi methyl ester-diesel and Undi ethyl ester-diesel blends.

J Therm Anal Calorim 2022 Apr 6:1-18. Epub 2022 Apr 6.

Department of Mechanical Engineering, National Institute of Technology, Agartala, India.

The current study emphasizes on the influence of nonedible, easily accessible Undi ester blended diesel in single-cylinder, four-stroke, naturally aspirated, direct-injection variable compression ratio diesel engine. All tests were accomplished by varying volumetric proportions of Undi methyl ester (UME) and Undi ethyl ester by 10%, 20%, 30%, 40%, and 50% and compression ratio (CR) from 16:1-20:1. The Undi esters consolidation to diesel, especially enhances brake thermal efficiency (BTE) and decreases brake specific energy consumption (BSEC) of the engine. Read More

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