3,482 results match your criteria Heatstroke


Liver transplantation in patients with liver failure related to exertional heatstroke.

J Hepatol 2018 Dec 3. Epub 2018 Dec 3.

AP-HP Hôpital Paul-Brousse, Centre Hépato-Biliaire, Liver Intensive Care Unit, Villejuif, F-94800, France; INSERM, Unité 1193, Université Paris-Saclay, Villejuif, F-94800, France; DHU Hepatinov, Villejuif, F-94800, France.

Severe acute liver injury (sALI) is a grave complication of exertional heatstroke (EH). Liver transplantation (LT) may be a therapeutic option, but the criteria for, and timing of transplantation have not been clearly established. The aim of this study was to define the profile of patients who require transplantation in this context. Read More

View Article
December 2018
3 Reads

Dyskinesia-Hyperpyrexia Syndrome in Parkinson's Disease: A Heat Shock-Related Emergency?

Mov Disord Clin Pract 2018 Sep-Oct;5(5):534-537. Epub 2018 Oct 3.

Neurology Service and Stroke Unit, AO Brotzu Hospital Cagliari Italy.

View Article
October 2018

Electrophysiology in diagnosis and management of neuropathic pain.

Rev Neurol (Paris) 2018 Oct 25. Epub 2018 Oct 25.

Inserm U1028, CNRS, UMR5292, central integration of pain (NeuroPain) Lab - Lyon neuroscience research center, université Claude Bernard, 69677 Bron, France; Department of Clinical Neurophysiology, Neurological Institute, Faculty of Medicine, Graduate School of Medical Science, Kyushu University, Fukuoka, 812-8582, Japan.

Electrophysiological techniques demonstrate abnormalities in somatosensory transmission, hence providing objective evidence of 'somatosensory lesion or disease' which is crucial to the diagnosis of neuropathic pain (NP). Since most instances of NP result from damage to thermo-nociceptive pathways (thin fibres and spino-thalamo-cortical systems), specific activation of these is critical to ensure diagnostic accuracy. This is currently achieved using laser pulses or contact heat stimuli, and in a near future probably also with contact cold and intra-epidermal low-intensity currents. Read More

View Article
October 2018

Dexmedetomidine Attenuates Acute Lung Injury Induced by Heatstroke and Improve Outcome.

Shock 2018 Nov 20. Epub 2018 Nov 20.

The Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, P. R. China.

Introduction: Dexmedetomidine (DEX) has been demonstrated to inhibit inflammatory response and protect against multiorgan injury in various scenarios. The objectives of the present study was to ascertain whether DEX is able to attenuate acute lung injury (ALI) under heatstroke (HS), and to explore the underlying mechanism.

Methods: Male C57BL/6 mice were exposed to ambient temperature of 39. Read More

View Article
November 2018
3 Reads

Simultaneous infrared thermal imaging and laser speckle imaging of brain temperature and cerebral blood flow in rats.

J Biomed Opt 2018 Nov;24(3):1-11

Kyoto University, Research and Educational Unit of Leaders for Integrated Medical System, Center for, Japan.

Infrared thermal imaging of brain temperature changes is useful for evaluating cortical activity and disease states, such as stroke. However, the changes depend on a balance between changes in heat generation from metabolism and in heat convection related to blood flow. To discriminate between these effects and gain a clearer understanding of neurovascular metabolic coupling, brain temperature imaging must be improved to measure temperature and blood flow simultaneously. Read More

View Article
November 2018

An experimental investigation of performance and emission of thumba biodiesel using butanol as an additive in an IDI CI engine and analysis of results using multi-objective fuzzy-based genetic algorithm.

Environ Sci Pollut Res Int 2018 Nov 21. Epub 2018 Nov 21.

Department of Production Engineering, National Institute of Technology Agartala, Tripura, 799046, India.

The present work studies the effect of butanol in thumba (Citrullus colocynthis) biodiesel in an IDI CI engine at varying percentages of 5 and 10% in 15 and 10% thumba biodiesel respectively with 80% diesel in each blend. Another blend was introduced with 80% diesel and 20% biodiesel without any additive. The experiment was conducted in a single cylinder four-stroke IDI CI engine at 1500 rpm varying from 25% to full-load (100%) conditions. Read More

View Article
November 2018
2 Reads

Heatstroke.

Handb Clin Neurol 2018 ;157:531-545

Intensive Care Unit and Experimental Medicine Department, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia. Electronic address:

Heatstroke is an acute medical emergency that is always fatal if left untreated. The diagnosis of heatstroke should be considered in any hyperthermic patient with altered mental status during a heat wave or following vigorous muscle exertion. Heat can damage the structure and function of essential macromolecules, including proteins, membrane lipids, and nucleic acids, and thereby lead to multiple-organ failure, culminating in death. Read More

View Article
January 2018
1 Read

Heat exhaustion.

Handb Clin Neurol 2018 ;157:505-529

Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada; Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba City, Japan.

Heat exhaustion is part of a spectrum of heat-related illnesses that can affect all individuals, although children, older adults, and those with chronic disease are particularly vulnerable due to their impaired ability to dissipate heat. If left uninterrupted, there can be progression of symptoms to heatstroke, a life-threatening emergency. Signs and symptoms of heat exhaustion may develop suddenly or over time. Read More

View Article
January 2018
1 Read

Pyroptosis of HUVECs can be induced by heat stroke.

Biochem Biophys Res Commun 2018 Nov 24;506(3):626-631. Epub 2018 Oct 24.

The First School of Clinical Medicine, Southern Medical University, Guangzhou, China; Department of Intensive Care Unit, General Hospital of Guangzhou Military Command, Key Laboratory of Tropical Trauma Care and Tissue Repair of PLA, Guangzhou, China. Electronic address:

Heat stroke is a serious pathological condition with high mortality. Vascular endothelial cell injury is a key feature in the pathogenesis of heat stroke, but the specific pathophysiological process whereby this occurs is still unclear. Currently, relevant studies are primarily based upon examination of apoptosis. Read More

View Article
November 2018
2 Reads

Interactions between body fluid homeostasis and thermoregulation in humans.

Handb Clin Neurol 2018 ;156:417-429

Department of Sports Medical Sciences, Shinshu University Graduate School of Medicine, Institute for Biomedical Sciences, Shinshu University, Matsumoto, Japan.

Humans are unique in their ability to control body temperature with a large amount of skin blood flow and sweat rate while exercising in an upright position. However, cutaneous vasodilation in the body reduces total peripheral resistance and blood pooling in cutaneous veins decreases venous return to the heart and cardiac filling pressure. In addition, hypovolemia by sweating accelerates the reduction in cardiac filling pressure. Read More

View Article
January 2018
3 Reads

Bone marrow-derived mononuclear cell therapy can attenuate systemic inflammation in rat heatstroke.

Scand J Trauma Resusc Emerg Med 2018 Nov 16;26(1):97. Epub 2018 Nov 16.

Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, 2-15 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Background: This study was performed to gain insights into novel therapeutic approaches for acute systemic inflammation in heatstroke. Bone marrow-derived mononuclear cells (BMMNCs) secrete anti-inflammatory proteins and have protective effects against acute inflammation. Recent evidence suggested that transplantation of BMMNCs can reduce the acute tissue injury caused by regional myocardial reperfusion and the lung dysfunction induced by lipopolysaccharides. Read More

View Article
November 2018
4 Reads

A combined banding method that allows the reliable identification of chromosomes as well as differentiation of AT- and GC-rich heterochromatin.

Chromosome Res 2018 Nov 15. Epub 2018 Nov 15.

Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Russia.

Сonstitutive heterochromatin areas are revealed by differential staining as C-positive chromosomal regions. These C-positive bands may greatly vary by location, size, and nucleotide composition. CBG-banding is the most commonly used method to detect structural heterochromatin in animals. Read More

View Article
November 2018
4 Reads

[Advances in pre-hospital recognition and cooling treatment of exertional heat stroke].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Oct;30(10):1006-1010

Department of ICU, No.401 Hospital of the People's Liberation Army, Qingdao 266071, Shandong, China. Corresponding author: Li Hailing, Email:

Objective: Heat stroke (HS) is a life-threatening illness characterized by an altered level of consciousness with an elevated core body temperature 40 centigrade, which may be further classified as exertional heat stroke (EHS) or classical heat stroke (CHS) according to the etiology of the condition. In recent years, the morbidity of EHS increases year by year. The severity and clinical outcome for an EHS casualty have a strong correlation with the area under the time and temperature curve for heat exposure. Read More

View Article
October 2018
1 Read

Multiple Patients With Heatstroke Air Evacuated by Agreement Concerning Collaboration.

Air Med J 2018 Nov - Dec;37(6):388-391. Epub 2018 Sep 3.

Department of Acute Critical Care Medicine, Shizuoka Hospital, Juntendo University, Shizouka, Japan. Electronic address:

On August 30, 2017, the wet-bulb globe temperature was 30°C. Three female military personnel fell unconscious almost simultaneously around noon after a long-distance march that had started at 6 am. The fire department in Gotenba received a 119 call [at 1:16 PM] and requested dispatch of the eastern Shizuoka doctor helicopter (DH) because it would take about 1 hour from the scene to arrive at our hospital by ground ambulance. Read More

View Article
September 2018
2 Reads

Very Delayed Remote Ischemic Post-conditioning Induces Sustained Neurological Recovery by Mechanisms Involving Enhanced Angioneurogenesis and Peripheral Immunosuppression Reversal.

Front Cell Neurosci 2018 29;12:383. Epub 2018 Oct 29.

Department of Neurology, University Duisburg-Essen Medical School, Essen, Germany.

Ischemic conditioning is defined as a transient and subcritical period of ischemia integrated in an experimental paradigm that involves a stimulus of injurious ischemia, activating endogenous tissue repair mechanisms that lead to cellular protection under pathological conditions like stroke. Whereas ischemic pre-conditioning is irrelevant for stroke treatment, ischemic post-conditioning, and especially non-invasive remote ischemic post-conditioning (rPostC) is an innovative and potential strategy for stroke treatment. Although rPostC has been shown to induce neuroprotection in stroke models before, resulting in some clinical trials on the way, fundamental questions with regard to its therapeutic time frame and its underlying mechanisms remain elusive. Read More

View Article
October 2018
3 Reads

Calpain-2 protects against heat stress-induced cardiomyocyte apoptosis and heart dysfunction by blocking p38 mitogen-activated protein kinase activation.

J Cell Physiol 2018 Nov 11. Epub 2018 Nov 11.

Department of Medicine, Critical Illness Research Center, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada.

Cardiovascular dysfunction is a common complication among heatstroke patients, but its underlying mechanism is unclear. This study was designed to investigate the role of calpain-2 and its downstream signal pathway in heat stress-induced cardiomyocyte apoptosis and heart dysfunction. In cultured primary mouse neonatal cardiomyocytes (MNCs), heat stress (43°C for 2 hr) induced a heat-shock response, as indicated by upregulated heat-shock protein 27 (HSP27) expression and cellular apoptosis, as indicated by increased caspase-3 activity, DNA fragmentation and decreased cell viability. Read More

View Article
November 2018
2 Reads

Determining Maximum Sublimation Rate for a Production Lyophilizer: Computational Modeling and Comparison with Ice Slab Tests.

J Pharm Sci 2018 Nov 8. Epub 2018 Nov 8.

School of Aeronautics and Astronautics, Purdue University, West Lafayette, IN 47907. Electronic address:

Equipment capability is an important factor in scale up and technology transfer for lyophilized pharmaceutical products. Experimental determination of equipment capability limits, such as the maximum sublimation rate at a given chamber pressure, is time intensive for production lyophilizers. Here we present computational fluid dynamics modeling of equipment capability and compare it with experimental data for Minimum Controllable Pressure ice slab sublimation tests in a 23 m shelf area freeze-dryer. Read More

View Article
November 2018
2 Reads

Physiological, biochemical and histopathological changes associated with heatstroke in the Galah (Eolophus roseicapilla) and Rock Dove (Columba livia).

Avian Pathol 2018 Nov 9:1-49. Epub 2018 Nov 9.

b School of Animal & Veterinary Sciences , University of Adelaide , Roseworthy Campus, SA 5371 Australia.

The pathophysiology of heat illnesses in birds has not been well characterised. In this study, we describe the changes in heart rate, respiratory rate, blood biochemistry and histopathological findings in galahs and rock doves after heat exposure under standardized conditions designed to induce heatstroke. Birds in the heat exposed group were exposed to environmental heat stress and compared to control birds. Read More

View Article
November 2018
3 Reads

Differential Expression Pattern of Exosome Long Non-Coding RNAs (lncRNAs) and MicroRNAs (miRNAs) in Vascular Endothelial Cells Under Heat Stroke.

Med Sci Monit 2018 Nov 6;24:7965-7974. Epub 2018 Nov 6.

Department of Critical Care Medicine, Guangzhou School of Clinical Medicine, Southern Medical University (Guangzhou General Hospital of Guangzhou Military Region), Guangzhou, Guangdong, China (mainland).

BACKGROUND Heat stroke is a life-threatening disease which is characterized by a high body temperature and multiple organ dysfunction syndrome. Vascular endothelial cell injury is a main feature of heat stroke. Little is known about the long noncoding RNA (lncRNA) and microRNA (miRNA) expression alternation in endothelial cell exosomes related to heat stroke. Read More

View Article
November 2018
11 Reads

Methylenecyclopropyl glycine, not pesticide exposure as the primary etiological factor underlying hypoglycemic encephalopathy in Muzaffarpur, India.

Toxicol Lett 2018 Oct 30;301:34-41. Epub 2018 Oct 30.

Food Toxicology Laboratory, Food, Drug and Chemical Toxicology Group, CSIR - Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31 Mahatma Gandhi Marg, Lucknow, India. Electronic address:

Some districts of Bihar, especially Muzzaffarpur district, have been known to be affected by annual outbreak, called locally as Acute Encephalitis Syndrome (AES) which became one of the major health concerns in Bihar, due to its high fatality and complications. Several hypotheses like bat virus, heat stroke, pesticide exposure and the presence of a compound - methylenecyclopropyl glycine (MCPG) in Litchi have been proposed by different investigators for AES. When the investigators examined the symptoms, signs and the epidemiological data, bat virus and heat stroke hypothesis were ruled out. Read More

View Article
October 2018
3 Reads

Carotid chemoreceptors have a limited role in mediating the hyperthermia-induced hyperventilation in exercising humans.

J Appl Physiol (1985) 2018 Nov 1. Epub 2018 Nov 1.

University of Tsukuba, Faculty of Health and Sport Sciences, Japan.

Hyperthermia causes hyperventilation at rest and during exercise. We previously reported that carotid chemoreceptors partly contribute to the hyperthermia-induced hyperventilation at rest. However, given that a hyperthermia-induced hyperventilation markedly differs between rest and exercise, the results obtained at rest may not be representative of the response in exercise. Read More

View Article
November 2018
2 Reads

Association between ambient temperature and mortality risk and burden: time series study in 272 main Chinese cities.

BMJ 2018 Oct 31;363:k4306. Epub 2018 Oct 31.

National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Xicheng District, Beijing 100050, China

Objectives: To examine the association between temperature and cause specific mortality, and to quantify the corresponding disease burden attributable to non-optimum ambient temperatures.

Design: Time series analysis.

Setting: 272 main cities in China. Read More

View Article
October 2018
8 Reads

Evaluating the impact of solar radiation on pediatric heat balance within enclosed, hot vehicles.

Temperature (Austin) 2018 23;5(3):276-292. Epub 2018 May 23.

School of Geographical Sciences and Urban Planning, Arizona State University, Tempe, AZ.

Pediatric deaths due to children being left in hot cars remain a significant yet preventable public health concern. The current study aims to demonstrate the influence of vehicle type, time of day, and solar exposure (sun or shade) on the energy balance and core temperature (T) of a hypothetical two-year old boy left in a vehicle on a hot day. Cabin temperatures and relative humidity were collected within six enclosed vehicles under sun or full shade in Tempe, Arizona. Read More

View Article

Dexmedetomidine preserves the endothelial glycocalyx and improves survival in a rat heatstroke model.

J Anesth 2018 Dec 29;32(6):880-885. Epub 2018 Oct 29.

Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, 431-3192, Japan.

Purpose: Heatstroke causes systemic inflammation, followed by vascular endothelial damage. The normal vascular endothelium is coated by endothelial glycocalyx (EGCX). Dexmedetomidine (DEX) has an anti-inflammatory effect, but there has been little investigation on the influence of heatstroke on EGCX and the effect of DEX on this condition. Read More

View Article
December 2018
1 Read

A random forest model to predict heatstroke occurrence for heatwave in China.

Sci Total Environ 2019 Feb 2;650(Pt 2):3048-3053. Epub 2018 Oct 2.

National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China. Electronic address:

Extreme heat events have recently become more frequent and represent an increasing risk of damage to public health. However, the existing prediction of heatwave related health effects has limited representativeness and verification. Our study addressed the prediction of heatstroke occurrences based on three years' data of typical cities of hot temperature in China, and examined the importance ranks of model parameters including meteorological and socioeconomic status (SES) factors. Read More

View Article
February 2019
2 Reads

Heat Sepsis Precedes Heat Toxicity in the Pathophysiology of Heat Stroke-A New Paradigm on an Ancient Disease.

Authors:
Chin Leong Lim

Antioxidants (Basel) 2018 Oct 25;7(11). Epub 2018 Oct 25.

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.

Heat stroke (HS) is an ancient illness dating back more than 2000 years and continues to be a health threat and to cause fatality during physical exertion, especially in military personnel, fire-fighters, athletes, and outdoor laborers. The current paradigm in the pathophysiology and prevention of HS focuses predominantly on heat as the primary trigger and driver of HS, which has not changed significantly for centuries. However, pathological and clinical reports from HS victims and research evidence from animal and human studies support the notion that heat alone does not fully explain the pathophysiology of HS and that HS may also be triggered and driven by heat- and exercise-induced endotoxemia. Read More

View Article
October 2018
4 Reads

Liver Injury Associated with Sporting Activities.

Semin Liver Dis 2018 Nov 24;38(4):357-365. Epub 2018 Oct 24.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.

Exertional heat stroke most commonly develops following prolonged levels of aerobic activity in a warm or humid environment. Hypoperfusion of the vital organs along with activation of the inflammasome can lead to progressive and potentially fatal multiorgan failure including acute liver failure. In the United States, herbal and dietary supplements that are marketed to improve performance, strength, and weight loss are increasingly being used by both amateur and professional athletes. Read More

View Article
November 2018
3 Reads

The added effects of heatwaves on cause-specific mortality: A nationwide analysis in 272 Chinese cities.

Environ Int 2018 Dec 20;121(Pt 1):898-905. Epub 2018 Oct 20.

School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai 200032, China; Key Laboratory of Reproduction Regulation of National Population and Family Planning Commission, Shanghai Institute of Planned Parenthood Research, Institute of Reproduction and Development, Fudan University, Shanghai 200032, China.. Electronic address:

Background: The evidence was limited and inconclusive about the added effects of heatwaves, especially in developing countries.

Objective: To evaluate the added effects of heatwaves on cause-specific mortality in China.

Methods: We designed a nationwide time-series analysis based on daily data from 272 main Chinese cities to from 2013 to 2015. Read More

View Article
December 2018
12 Reads

Rhabdomyolysis of Unknown Etiology - Initial Suspicion and Detection on 99mTc-MDP Skeletal Scintigraphy.

J Assoc Physicians India 2018 Jan;66(1):84

Department of Medicine, Vijaya Diagnostic Centre, Visakhapatnam, Andhra Pradesh.

The classical bone scan findings of Rhabdomyolysis is presented in this illustration. A 60 year old female patient with complaints of low backache and bilateral lower limbs weakness over 1 year was referred for whole body skeletal status evaluation. Whole body skeletal scintigraphy undertaken 3 hrs after I. Read More

View Article
January 2018
4 Reads

Occupational fatal injuries associated with mobile hand-fed wood chippers.

Am J Ind Med 2018 Dec 16;61(12):978-985. Epub 2018 Oct 16.

Bureau of Occupational Health and Injury Prevention, New York State Department of Health, Albany, New York.

Background: Workers are killed every year in wood chipper-related incidents despite the repeated hazard warnings. In-depth, comprehensive, and up-to-date studies are needed to identify causal, risk, and contributing factors and assess the current control measures so that an effective and proactive prevention approach can be developed.

Methods: Cases were identified from four online databases and manually reviewed to characterize and categorize the fatal events. Read More

View Article
December 2018
9 Reads

Possible fatal hyperthermia involving drug abuse in a vehicle: case series.

Forensic Sci Int 2018 Nov 29;292:e20-e24. Epub 2018 Sep 29.

DIMEC, University of Bologna, Department of Medical and Surgical Sciences, 40126 Bologna, Italy.

Major interplaying causes of heat stroke (HS) and fatal hyperthermia are climate, physical activity, artificial extreme ambient temperatures, confinement in a small compartment, and effects of drugs and chemicals, combined with predispositions and complications. A common and unfortunate cause of HS is vehicular hyperthermia (VH) death. Hyperthermia in a vehicle is a type of environmental thermal disorder, involving victim's susceptibility, confinement with restraint, and possible influences of drugs and poisons, including exhaust gas containing complex fumes, carbon dioxide and monoxide. Read More

View Article
November 2018
1 Read

Association between heat stroke and ischemic heart disease: A national longitudinal cohort study in Taiwan.

Eur J Intern Med 2018 Oct 5. Epub 2018 Oct 5.

Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Center for the Prevention and Treatment of Heat Stroke, Tri-Service General Hospital, Taipei, Taiwan. Electronic address:

The purpose of this study is to determine the relationship between heat stroke and ischemic heart disease (IHD), in a nationwide population using a longitudinal approach. We retrospectively examined the data from the National Health Insurance Research Database (NHIRD) in Taiwan, for patients examined between 2000 and 2013. In total, 628 patients with a heat stroke episode were enrolled and matched with 1256 patients without any history of a heat stroke episode by propensity score matching at a ratio of 1:2. Read More

View Article
October 2018
1 Read

Moxibustion-Simulating Bipolar Radiofrequency Suppresses Weight Gain and Induces Adipose Tissue Browning via Activation of UCP1 and FGF21 in a Mouse Model of Diet-Induced Obesity.

Evid Based Complement Alternat Med 2018 10;2018:4737515. Epub 2018 Sep 10.

College of Korean Medicine, Dongguk University, 32 Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 10326, Republic of Korea.

Background: Obesity is a pathological condition associated with various diseases including diabetes, stroke, arthritis, infertility, and heart disease. Moxibustion is widely used to prevent and manage obesity in traditional Asian medicine. We tested our hypothesis that moxibustion-simulating bipolar radiofrequency (M-RF) can suppress total body and white adipose tissue (WAT) weight gain via induction of WAT browning in a mouse model of diet-induced obesity (DIO). Read More

View Article
September 2018
7 Reads

Combustion, performance, and emission analysis of diesel engine fueled with water-biodiesel emulsion fuel and nanoadditive.

Environ Sci Pollut Res Int 2018 Nov 28;25(33):33478-33489. Epub 2018 Sep 28.

Department of Mechanical Engineering, Karunya University, Coimbatore, India.

The present study is aimed to analyze the combustion, performance, and emission characteristics of water-emulsified soybean biodiesel fueled diesel engine with alumina nanoadditive and the results compared with conventional diesel fuel (BD). Experiments were conducted in a single-cylinder, four-stroke, variable compression ratio, and natural aspirated diesel engine with an eddy current dynamometer at a constant speed of 1500 rpm. Water-soybean biodiesel emulsion fuel was prepared using a mechanical agitator, in which the water concentration was limited to 10%, whereas soybean biodiesel (SB) and surfactant concentrations were 89% and 1% by volume respectively. Read More

View Article
November 2018
8 Reads

Proteomic identification of hippocalcin and its protective role in heatstroke-induced hypothalamic injury in mice.

J Cell Physiol 2018 Sep 7. Epub 2018 Sep 7.

Department of Critical Care Medicine, General Hospital of Guangzhou Military Command, Guangzhou, China.

Heatstroke is a devastating condition that is characterized by severe hyperthermia and central nervous system dysfunction. However, the mechanism of thermoregulatory center dysfunction of the hypothalamus in heatstroke is unclear. In this study, we established a heatstroke mouse model and a heat-stressed neuronal cellular model on the pheochromocytoma-12 (PC12) cell line. Read More

View Article
September 2018
2 Reads

Small Heat Shock Proteins, Amyloid Fibrils, and Nicotine Stimulate a Common Immune Suppressive Pathway with Implications for Future Therapies.

Cold Spring Harb Perspect Med 2018 Sep 24. Epub 2018 Sep 24.

Department of Neurology, Stanford University School of Medicine, Stanford, California 94305-5316.

The α7 nicotinic acetylcholine receptor (α7nAChR) is central to the anti-inflammatory function of the vagus nerve in a physiological mechanism termed the inflammatory reflex. Studies on the inflammatory reflex have been instrumental for the current development of the field of bioelectronic medicine. An independent investigation of the biological role of αB-crystallin (HspB5), the most abundant gene transcript present in active multiple sclerosis lesions in human brains, also led to α7nAChR. Read More

View Article
September 2018
14 Reads

Calycosin-7-O-β-D-glucoside reduces myocardial injury in heat stroke rats.

J Formos Med Assoc 2018 Sep 20. Epub 2018 Sep 20.

Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan; Department of Intensive Care Medicine, Chi Mei Medical Center, Tainan, Taiwan. Electronic address:

Background/purpose: Calycosin-7-O-β-D-glucoside (CG), a calycosin derivative compound derived from Astragali Radix, has protective effect against ischemia/reperfusion injury as well as bacterial endotoxin-induced vascular cell injury. In the present study, we ascertained whether CG could reduce myocardial injury in heatstroke rats.

Methods: Heat stroke was induced by exposing anaesthetized rats to heat stress (43 °C for 70 min). Read More

View Article
September 2018
4 Reads

Malignant hyperthermia, environmental heat stress, and intracellular calcium dysregulation in a mouse model expressing the p.G2435R variant of RYR1.

Br J Anaesth 2018 Oct 10;121(4):953-961. Epub 2018 Aug 10.

Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Molecular Biosciences, School of Veterinary Medicine, University of California at Davis, Davis, CA, USA; Leeds Institute of Biomedical & Clinical Sciences, University of Leeds, Leeds, UK. Electronic address:

Background: The human p.G2434R variant of the RYR1 gene is most frequently associated with malignant hyperthermia (MH) in the UK. We report the phenotype of a knock-in mouse that expresses the RYR1 variant p. Read More

View Article
October 2018
4 Reads

Evaluation of a Novel Classification of Heat-Related Illnesses: A Multicentre Observational Study (Heat Stroke STUDY 2012).

Int J Environ Res Public Health 2018 09 8;15(9). Epub 2018 Sep 8.

Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan.

The Japanese Association for Acute Medicine Committee recently proposed a novel classification system for the severity of heat-related illnesses. The illnesses are simply classified into three stages based on symptoms and management or treatment. Stages I, II, and III broadly correspond to heat cramp and syncope, heat exhaustion, and heat stroke, respectively. Read More

View Article
September 2018
1 Read

Targeted Temperature Management: Peltier's Element-Based Focal Brain Cooling Protects Penumbra Neurons from Progressive Damage in Experimental Cerebral Ischemia.

Ther Hypothermia Temp Manag 2018 Sep 8. Epub 2018 Sep 8.

4 Department of Anesthesiology, Kurume University School of Medicine , Kurume, Japan .

Targeted temperature management (TTM), or therapeutic hypothermia, is one of the most potent neuroprotective approaches after ischemic and traumatic brain injuries. TTM has been applied clinically with various methods, but effective achievement and maintenance of the target temperature remain challenging. Furthermore, timing of cooling and target body and brain temperature to optimize effectiveness for neuroprotection and to minimize side effects are yet to be standardized. Read More

View Article
September 2018
1 Read

Characterization of heat shock protein 27 in extracellular vesicles: a potential anti-inflammatory therapy.

FASEB J 2018 Sep 6:fj201800987R. Epub 2018 Sep 6.

Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Previously, we reported that elevated serum levels of heat shock protein 27 (HSP27) are predictive of a lower risk of having a heart attack, stroke, or death from cardiovascular disease. Moreover, augmenting HSP27 (or the murine ortholog, HSP25) attenuated experimental atherogenesis, reduced inflammation, and lowered cholesterol levels. Recently, we noted that HSP27 activates NF-κB via TLR-4, resulting in attenuation of plaque inflammation; however, the precise anti-atherosclerosis mechanisms mediated by extracellular HSP27 are incompletely understood. Read More

View Article
September 2018
1 Read

Personal risk factors associated with heat-related illness among new conscripts undergoing basic training in Thailand.

PLoS One 2018 4;13(9):e0203428. Epub 2018 Sep 4.

Department of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok, Thailand.

Cases of exertional heat stroke have been reported every year during basic training for Royal Thai Army (RTA) conscripts. Prevention is an important strategy to reduce the incidence of heat-related illnesses. We conducted a study to identify potential indicators for the prevention and monitoring of heat-related illnesses among military conscripts undergoing basic training in Thailand. Read More

View Article
September 2018
9 Reads

Heatwave and mortality in 31 major Chinese cities: Definition, vulnerability and implications.

Sci Total Environ 2019 Feb 26;649:695-702. Epub 2018 Aug 26.

State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. Electronic address:

Few data are available on the health impacts of heatwaves in China, and in particular, the heatwave definition and vulnerable populations remain to be identified. We collected data on daily maximum temperature and mortality from 31 Chinese capital cities during 2007-2013. A Poisson regression model allowing for over-dispersion was applied to estimate the short-term effects of heatwaves on mortality in hot season (May-September). Read More

View Article
February 2019
13 Reads
4.100 Impact Factor

Management of exertional heat stroke.

Authors:
William M Adams

Br J Gen Pract 2018 Sep;68(674):415-416

University of North Carolina at Greensboro, US. Email:

View Article
September 2018

Neuroprotective Effects of Heat Shock Protein70.

CNS Neurol Disord Drug Targets 2018 ;17(10):736-742

Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Background & Objective: Heat Shock Proteins (HSPs) increase response to many stresses in cells. Stroke is a neural shock that leads to the destruction of a large number of brain cells, whereas induction and expression of HSPs can decrease the amount of damage, and in some conditions can cure damaged cells. HSP70 family is considered as the most important member of HSPs in normal and stress condition of cells. Read More

View Article
January 2018
5 Reads

Incidence and Characteristics of Bath-related Accidents.

Intern Med 2018 Aug 24. Epub 2018 Aug 24.

Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Japan.

Objectives Bath-related sudden cardiac arrests frequently occur in Japan. This study aimed to describe the actual incidence and characteristics of bath-related accidents, including non-fatal events, and to establish the etiology of bath-related sudden cardiac arrest. Methods This prospective cross-sectional observational study was conducted in Tokyo Metropolis and Saga and Yamagata Prefectures between October 2012 and March 2013. Read More

View Article
August 2018
7 Reads

The Effects of Mouse Recombinant Resistin on mRNA Expression of Proinflammatory and Anti-Inflammatory Cytokines and Heat Shock Protein-70 in Experimental Stroke Model.

J Stroke Cerebrovasc Dis 2018 Nov 16;27(11):3272-3279. Epub 2018 Aug 16.

Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran.

Background: Our recent research showed that resistin has a neuroprotective effect against stroke-induced injury through suppressing apoptosis and oxidative stress. However, the molecular mechanism of neuroprotection of resistin is unclear. This work was designed to examine the effect of mouse recombinant resistin on mRNA expression of Tumor necrosis factor-α (TNF-α), Interleukin-1β (IL-1β), Interleukin-10 (IL-10), Transforming growth factor-β1 (TGF- β1), and Heat shock protein-70 (HSP-70) in mouse model of stroke. Read More

View Article
November 2018
3 Reads
1.990 Impact Factor

Heat Stroke as a Cause of Liver Failure and Evaluation of Liver Transplant.

Exp Clin Transplant 2018 Aug 17. Epub 2018 Aug 17.

Department of Surgery, Division of Organ Transplantation, UMass Memorial Medical Center, University of Massachusetts, Worcester, Massachusetts, USA.

Heat stroke is a multiple organ dysfunction syndrome of poorly understood pathogenesis. Exertional heat stroke with acute liver failure is a rarely reported condition. Liver transplant has been recommended as treatment in cases of severe liver dysfunction; however, there are only 5 described cases of long-term survival after this procedure in patients with heat stroke. Read More

View Article
August 2018
2 Reads

Adjuvant rhubarb alleviates organs dysfunction and inhibits inflammation in heat stroke.

Exp Ther Med 2018 Aug 20;16(2):1493-1498. Epub 2018 Jun 20.

Intensive Care Unit, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China.

The aim of the present study was to investigate the effects of adjuvant rhubarb on the recovery of patients with heat stroke. A total of 85 patients with heat stroke were randomly assigned to two treatment groups: One group receiving conventional treatment for heat stroke (conventional group) and one group receiving rhubarb supplement in addition to conventional treatment (rhubarb group). Liver and kidney function parameters, Acute Physiology and Chronic Health Evaluation (APACHE) II scores, plasma interleukin-6 (IL-6), procalcitonin (PCT), C-reactive protein (CRP) levels and venous white blood cell count (WBC) were analyzed. Read More

View Article
August 2018
2 Reads

Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma.

Nat Commun 2018 08 10;9(1):3209. Epub 2018 Aug 10.

Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, 02114, MA, USA.

Glaucoma is the most prevalent neurodegenerative disease and a leading cause of blindness worldwide. The mechanisms causing glaucomatous neurodegeneration are not fully understood. Here we show, using mice deficient in T and/or B cells and adoptive cell transfer, that transient elevation of intraocular pressure (IOP) is sufficient to induce T-cell infiltration into the retina. Read More

View Article
August 2018
2 Reads