J Heart Lung Transplant 2022 May 20. Epub 2022 May 20.
Toronto Lung Transplant Program, Latner Thoracic Research Laboratories, University Health Network, Toronto, Ontario, Canada; Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada; Division of Respirology, Department of Medicine, University of Toronto, 27 King's College Cir, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, 27 King's College Cir, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, 27 King's College Cir, Toronto, Ontario, Canada. Electronic address:
Background: Lung transplant recipients experience episodes of immune-mediated acute lung allograft dysfunction (ALAD). ALAD episodes are a risk factor for chronic lung allograft dysfunction (CLAD), the major cause of death after lung transplantation. Our objective was to determine key cellular elements in dysfunctional lung allografts, with a focus on macrophages. Read More