73,855 results match your criteria Heart Transplantation


Poor Late Outcomes after Tricuspid Valve Repair in Single Ventricle: The Experience of 103 Patients.

Ann Thorac Surg 2020 Jul 4. Epub 2020 Jul 4.

Department of Cardiac Surgery, Royal Children's Hospital, Melbourne, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Australia; Heart Research, Murdoch Children's Research Institute, Melbourne, Australia. Electronic address:

Background: Outcomes of tricuspid valve repair in single ventricle palliation are poor. We sought to identify the impact of repair technique and primary mechanisms of regurgitation on outcomes following surgery.

Methods: A retrospective review of medical records across four centres undertaking single ventricle palliation in Australia and New Zealand was performed. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.05.070DOI Listing

Post-Transplant Survey to Assess Patient Experiences with Donor-Derived HCV Infection.

Transpl Infect Dis 2020 Jul 7:e13402. Epub 2020 Jul 7.

Department of Medicine, University of California San Diego, La Jolla, USA.

Background: Despite increased utilization of hepatitis C virus infected (HCV+) organs for transplantation into HCV-uninfected recipients, there is lack of standardization in HCV-related patient education/consent and limited data on financial and social impact on patients.

Methods: We conducted a survey on patients with donor-derived HCV infection at our center transplanted between 4/1/2017-11/1/2019 to assess: why patients chose to accept HCV+ organ(s), the adequacy of their pre-transplant HCV education and informed consent process, financial issues related to copays after discharge, and social challenges they faced.

Results: Among 49 patients surveyed, transplanted organs included heart (n=19), lung (n=9), kidney (n=11), liver (n=4), heart/kidney (n=4) and liver/kidney (n=2). Read More

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http://dx.doi.org/10.1111/tid.13402DOI Listing

Heart Transplantation in the Era of the SARS-CoV-2 Pandemic: Is It Safe and Feasible?

Clin Transplant 2020 Jul 7:e14029. Epub 2020 Jul 7.

Cedars-Sinai Smidt Heart Institute, 127 S San Vicente Blvd, Los Angeles, CA, 90048, United States.

As the SARS-CoV-2 pandemic continues to unfold, the number of heart transplants completed in the United States has been declining steadily. The current case series examines the immediate short-term outcomes of 7 heart transplant recipients transplanted during the SARS-CoV-2 pandemic. We hope to illustrate that with proper preparation, planning, and testing, heart transplantation can be continued during a pandemic. Read More

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http://dx.doi.org/10.1111/ctr.14029DOI Listing

Management and tolerability of glecaprevir-pibrentasvir pharmacotherapy in hepatitis C viremic heart and lung transplant recipients.

Clin Transplant 2020 Jul 6:e14030. Epub 2020 Jul 6.

Department of Cardiothoracic Surgery, NYU Langone Health, New York, NY, USA.

We conducted a retrospective review of thoracic transplant recipients (22 heart and 16 lung transplant recipients) prospectively enrolled in a single-center observational study of HCV NAT+ organ transplantation in HCV NAT- recipients. All recipients were treated with 8 weeks of glecaprevir-pibrentasvir (GP) for HCV viremia in addition to standard triple immunosuppression post-transplant. Thoracic transplant recipients of HCV NAT- organs were used as a control (24 heart and 22 lung transplant recipients). Read More

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http://dx.doi.org/10.1111/ctr.14030DOI Listing

Pathogenesis of non-alcoholic fatty liver disease and implications on cardiovascular outcomes in liver transplantation.

Transl Gastroenterol Hepatol 2020 5;5:36. Epub 2020 Jul 5.

University of Tennessee Health Science Center, Memphis, TN, USA.

Along with the obesity epidemic there has been a major increase in non-alcoholic fatty liver disease (NAFLD) prevalence, paralleling a steady increase in cirrhosis of the liver and hepatocellular cancer (HCC) related to NAFLD. Currently, NAFLD (related HCC and cirrhosis) is the second most common cause for liver transplantation (LT) and it is projected to take the top spot in the next 3-5 years. Patients with NAFLD cirrhosis and HCC have a unique set of comorbidities which potentially increases their risk for cardiovascular disease (CVD) and mortality. Read More

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http://dx.doi.org/10.21037/tgh.2019.12.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063524PMC

Cardiorenal Syndrome in Renal Transplant Recipients: Prevalence, Clinical Presentation, Treatment, and Outcome.

Cardiorenal Med 2020 Jul 6:1-7. Epub 2020 Jul 6.

Department of Nephrology, Arterial Hypertension, Dialysis, and Transplantation, University Hospital Center Zagreb, Faculty of Medicine, University of Zagreb, Zagreb, Croatia.

Background: Data on the cardiorenal syndrome (CRS) in renal transplant recipients (RTR) are scarce. We investigated the prevalence, clinical presentation, treatment, and outcomes of patients with CRS in our renal transplant cohort.

Methods: Charts and medical records of adult RTR were investigated to identify patients with renal allograft dysfunction and heart failure (HF) with reduced (HFrEF) or preserved (HFpEF) ejection fraction. Read More

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http://dx.doi.org/10.1159/000507728DOI Listing

Hematopoietic stem-cell senescence and myocardial repair - Coronary artery disease genotype/phenotype analysis of post-MI myocardial regeneration response induced by CABG/CD133+ bone marrow hematopoietic stem cell treatment in RCT PERFECT Phase 3.

EBioMedicine 2020 Jul 3;57:102862. Epub 2020 Jul 3.

Reference and Translation Center for Cardiac Stem Cell Therapy, Department Life, Light and Matter and Department of cardiac surgery, University Medicine Rostock, Schillingallee 35, 18055 Rostock, Germany. Electronic address:

Background: Bone marrow stem cell clonal dysfunction by somatic mutation is suspected to affect post-infarction myocardial regeneration after coronary bypass surgery (CABG).

Methods: Transcriptome and variant expression analysis was studied in the phase 3 PERFECT trial post myocardial infarction CABG and CD133 bone marrow derived hematopoetic stem cells showing difference in left ventricular ejection fraction (∆LVEF) myocardial regeneration Responders (n=14; ∆LVEF +16% day 180/0) and Non-responders (n=9; ∆LVEF -1.1% day 180/0). Read More

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http://dx.doi.org/10.1016/j.ebiom.2020.102862DOI Listing

Donors after circulatory death heart trial.

Future Cardiol 2020 Jul 6. Epub 2020 Jul 6.

Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305-5407, USA.

Orthotopic heart transplantation is the gold standard treatment for end-stage heart failure. However, the persistent shortage of available donor organs has resulted in an ever-increasing waitlist and longer waiting periods for transplantation. On the contrary, increasing the number of heart transplants by preserving extended criteria donors and donation after circulatory death hearts with the Organ Care System™ (OCS) Heart System has the potential to provide the gold standard, life-saving treatment to patients with end-stage heart failure. Read More

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http://dx.doi.org/10.2217/fca-2020-0070DOI Listing

Racial disparities and outcomes of left ventricular assist device implantation as a bridge to heart transplantation.

ESC Heart Fail 2020 Jul 6. Epub 2020 Jul 6.

Department of Surgery, Division of Cardiac Surgery, Rutgers Robert Wood Johnson University Hospital, New Brunswick, NJ, USA.

Aims: This study investigated outcomes after continuous flow left ventricular assist device (CF-LVAD) implantation as bridge to heart transplantation (BTT) in advanced heart failure patients stratified by race.

Methods And Results: De-identified data from the United Network for Organ Sharing database was obtained for all patients who had a CF-LVAD as BTT from 2008 to 2018. Patients were stratified into four groups on the basis of ethnicity [Caucasian, African American (AA), Hispanic, and others (Asian, Pacific Islanders, and American Indian)]. Read More

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http://dx.doi.org/10.1002/ehf2.12866DOI Listing

Implantable cardiac defibrillator leads dysfunction after LVAD implantation.

Pacing Clin Electrophysiol 2020 Jul 5. Epub 2020 Jul 5.

Univ Rennes, CHU Rennes, INSERM, LTSI - UMR 1099, Rennes, F-35000, France.

Background: Implantable cardioverter-defibrillator (ICD) lead dysfunction have been reported after left ventricular assist device (LVAD) implantation in limited single-center studies. We aimed to describe and characterize the incidence of ICD lead parameters dysfunction after LVAD implantation.

Methods: Among the 652 patients enrolled in the ASSIST-ICD study, only patients with an ICD prior to LVAD were included (n = 401). Read More

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http://dx.doi.org/10.1111/pace.14004DOI Listing

Differential Role for Activating FcγRIII in Neointima Formation After Arterial Injury and Diet-Induced Chronic Atherosclerosis in Deficient Mice.

Front Physiol 2020 17;11:673. Epub 2020 Jun 17.

Institute for Molecular Cardiovascular Research (IMCAR), University Hospital, RWTH Aachen University, Aachen, Germany.

Atherogenesis and arterial remodeling following mechanical injury are driven by inflammation and mononuclear cell infiltration. The binding of immune complexes (ICs) to immunoglobulin (Ig)-Fc gamma receptors (FcγRs) on most innate and adaptive immune cells induces a variety of inflammatory responses that promote atherogenesis. Here, we studied the role of FcγRIII in neointima formation after arterial injury in atherosclerosis-prone mice and compared the outcome and mechanism to that of FcγRIII in diet-induced "chronic" atherosclerosis. Read More

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http://dx.doi.org/10.3389/fphys.2020.00673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313534PMC

Outcomes after heart transplantation for al compared to attr cardiac amyloidosis.

Clin Transplant 2020 Jul 5:e14028. Epub 2020 Jul 5.

Center for Advanced Cardiac Care, Division of Cardiology, Columbia College of Physicians & Surgeons, New York, NY, USA.

Light-chain (AL) cardiac amyloidosis (CA) has a worse prognosis than transthyretin (ATTR) CA. In this single-center study, we compared post heart transplant (OHT) survival for AL and ATTR amyloidosis, hypothesizing that these differences would persist post-OHT. Thirty-nine patients with CA (AL, n=18; ATTR, n=21) and 1,023 non-amyloidosis subjects undergoing OHT were included. Read More

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http://dx.doi.org/10.1111/ctr.14028DOI Listing

Generation of functional lungs with pluripotent stem cells.

Allergy 2020 Jul 4. Epub 2020 Jul 4.

Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario "A Gemelli" - IRCCS, University of the Sacred Heart. Rome, Italy.

Millions of people of all ages suffer from chronic respiratory diseases (CRDs), including asthma, respiratory allergies and chronic obstructive pulmonary disease. To date, although significant advances have been made in terms of treatment, end-stage CRDs still remains one of the most frequent causes of death worldwide with a death rate that has been increasing over the past few years. Lung transplantation is the only therapeutic option when other treatments fail. Read More

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http://dx.doi.org/10.1111/all.14485DOI Listing

Dipeptidyl Peptidase-4 Inhibitor Decreases Allograft Vasculopathy Via Regulating the Functions of Endothelial Progenitor Cells in Normoglycemic Rats.

Cardiovasc Drugs Ther 2020 Jul 4. Epub 2020 Jul 4.

Division of Cardiovascular Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Purpose: Chronic rejection induces the occurrence of orthotopic allograft transplantation (OAT) vasculopathy, which results in failure of the donor organ. Numerous studies have demonstrated that in addition to regulating blood sugar homeostasis, dipeptidyl peptidase-4 (DPP-4) inhibitors can also provide efficacious therapeutic and protective effects against cardiovascular diseases. However, their effects on OAT-induced vasculopathy remain unknown. Read More

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http://dx.doi.org/10.1007/s10557-020-07013-wDOI Listing

A Frailty Screening Tool for Patients undergoing Orthotopic Heart Transplant.

Ann Thorac Surg 2020 Jul 2. Epub 2020 Jul 2.

Division of Cardiac Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA. Electronic address:

Background: Although frailty has been previously shown to negatively influence post-operative outcomes, frailty measurements remain undefined and underutilized for patients undergoing orthotopic heart transplantation (OHT). This study aims to derive and validate an OHT frailty screening tool.

Methods: The UNOS database was queried for adults undergoing OHT between 2000 and 2018. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.05.072DOI Listing

Urgently listed lung transplant patients have outcomes similar to those of electively listed patients.

J Thorac Cardiovasc Surg 2020 Apr 21. Epub 2020 Apr 21.

Department of Thoracic and Cardiovascular Surgery, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio; Transplant Institute, Cleveland Clinic, Cleveland, Ohio; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address:

Objectives: To (1) determine outcomes after urgent listing compared with elective listing for lung transplant and (2) compare in-hospital morbidity and mortality, survival, and allograft function in these 2 groups.

Methods: From January 2006 to September 2017, 201 patients were urgently and 1423 electively listed. Among urgently listed patients, 130 subsequently underwent primary lung transplant as did 995 electively listed patients. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2020.02.140DOI Listing

Impact of Early Initiation of Direct-Acting Antiviral Therapy in Thoracic Organ Transplantation from Hepatitis C Virus Positive Donors.

Semin Thorac Cardiovasc Surg 2020 Jul 1. Epub 2020 Jul 1.

Department of Cardiothoracic Surgery, NYU Langone Health, New York, NY.

Thoracic organs from Hepatitis C virus (HCV) positive donors are not commonly used for transplantation. The development of direct-acting antivirals (DAA) for HCV treatment has led to renewed interest in using HCV-positive organs. We evaluated HCV transmission rates, viremia clearance, and short-term outcomes in HCV-negative patients who received HCV-positive thoracic organs at our institution. Read More

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http://dx.doi.org/10.1053/j.semtcvs.2020.06.045DOI Listing

Effect of remote patient management in peritoneal dialysis on hemodynamic and volume control.

Nephrology (Carlton) 2020 Jul 3. Epub 2020 Jul 3.

Department of Nephrology Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy.

Aim: Reduced treatment compliance in patients with peritoneal dialysis facilitates the development of fluid overload and as a result increased blood pressure and vascular stiffness in the long term. We aimed to evaluate blood pressure change and antihypertensive needs of patients within one year after changeover to remote monitoring automated peritoneal dialysis (RM-APD) and compare the effect of RM-APD and continuous ambulatory peritoneal dialysis (CAPD) on peripheral and central hemodynamic parameters, volume status of patients and antihypertensive drug needs.

Methods: This was an observational and cross-sectional study. Read More

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http://dx.doi.org/10.1111/nep.13751DOI Listing

Health-Related Quality of Life of Heart Transplant Recipients Living in a Developing Country.

Transplant Proc 2020 Jun 30. Epub 2020 Jun 30.

School of Medicine, Federal University of Minas Gerais, Professor Alfredo Balena Avenue, 190, 30.130-100, Belo Horizonte, Minas Gerais, Brazil; University Hospital of the Federal University of Minas Gerais, Professor Alfredo Balena Avenue, 110, 30.130-100, Belo Horizonte, Minas Gerais, Brazil.

Background: Heart transplantation (HT) is the treatment for patients with end-stage heart failure (HF). It is hoped that the procedure increases both survival rates and the level of health-related quality of life (HRQoL), which may, however, be compromised by post-transplant complications. The objective of this study was to analyze the level of HRQoL in HT recipients and considered the influence of variables from social and clinical contexts. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.05.027DOI Listing

Iron overload and its impact on outcome of patients with hematological diseases.

Mol Aspects Med 2020 Jul 1:100868. Epub 2020 Jul 1.

University of Leipzig Medical Center, Medical Department I - Hematology and Cell Therapy, Hemostaseology, Germany.

Systemic iron overload (SIO) is a common challenge in patients with hematological diseases and develops as a result of ineffective erythropoiesis, multiple red blood cell (RBC) transfusions and disease-specific therapies. Iron homeostasis is tightly regulated as there is no physiological pathway to excrete iron from the body. Excess iron is, therefore, stored in tissues like liver, heart and bone marrow and can lead to progressive organ damage. Read More

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http://dx.doi.org/10.1016/j.mam.2020.100868DOI Listing

Current state of kidney utilization in multiorgan transplants.

Curr Opin Organ Transplant 2020 Jun 30. Epub 2020 Jun 30.

Department of Surgery, Division of Hepatobiliary, Pancreas, and Abdominal Organ Transplant, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Purpose Of Review: In the United States, the leading indication for kidney transplant is primary kidney dysfunction arising from chronic hypertension and diabetes. However, an increasing indication for kidney transplantation is secondary kidney dysfunction in the setting of another severe organ dysfunction, including pancreas, liver, heart, and lung disease. In these settings, multiorgan transplantation is now commonly performed. Read More

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http://dx.doi.org/10.1097/MOT.0000000000000777DOI Listing

Quality of economic evaluations of ventricular assist devices: A systematic review.

Int J Technol Assess Health Care 2020 Jun 18:1-8. Epub 2020 Jun 18.

Pharmacy Department, Georges Pompidou European Hospital, AP-HP, 20 Rue Leblanc, 75015Paris, France.

Objective: Because of a lack of suitable heart donors, alternatives to transplantation are required. These alternatives can have high costs. The aim of this study was to perform a systematic review of cost-effectiveness studies of ventricular assist devices (VADs) and to assess the level of evidence of relevant studies. Read More

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http://dx.doi.org/10.1017/S0266462320000409DOI Listing

PAPA spectrum disorders.

G Ital Dermatol Venereol 2020 Jul 2. Epub 2020 Jul 2.

Department of Medical-Surgical Pathophysiology and Transplantation, University of Milan, Milan, Italy -

Pyogenic arthritis, pyoderma gangrenosum (PG) and acne (PAPA) syndrome is an autosomal dominant autoinflammatory syndrome due to mutations in proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1) gene and presenting with cutaneous and articular manifestations. Other autoinflammatory syndromes caused by mutations in PSTPIP1 gene or characterized by clinical findings overlapping with those found in PAPA syndrome have been recently included in the group of PAPA spectrum disorders. These disorders are PASH (PG, acne and hidradenitis suppurativa [HS]), PAPASH (PASH associated with pyogenic sterile arthritis), PsAPASH (PASH combined with psoriatic arthritis [PsA], PASS (PG, acne, ankylosing spondylitis, with or without HS), PAC (PG, acne and ulcerative colitis [UC]) and PAMI syndrome (PSTPIP1-associated myeloid-related-proteinemia inflammatory syndrome). Read More

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http://dx.doi.org/10.23736/S0392-0488.20.06629-8DOI Listing

Haemophagocytic lymphohistiocytosis after heart transplantation: a case report.

Eur Heart J Case Rep 2020 Jun 3;4(3):1-4. Epub 2020 May 3.

Department of Transplant Institute, Sahlgrenska University Hospital, SE-413 25, Gothenburg, Sweden.

Background: Haemophagocytic lymphohistiocytosis (HLH) is an uncommon but serious systemic inflammatory response with high mortality rates. It can be triggered by malignancy or infectious agents, often in the context of immunosuppression. Literature covering HLH in heart transplantation (HTx) is scarce. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319853PMC

Idiopathic endomyocardial fibrosis in a Western European: a case report.

Eur Heart J Case Rep 2020 Jun 1;4(3):1-5. Epub 2020 Jun 1.

Cardiology Department, Reims University Hospital, Avenue du Général Koenig, 51092 Reims, France.

Background: Endomyocardial fibrosis (EMF) is a rare cause of restrictive cardiomyopathy, mainly found in tropical/subtropical country. Endomyocardial fibrosis causes severe congestive symptoms and may lead to end-stage heart failure.

Case Summary: A French Caucasian 44-year-old man without noticeable medical history and who had never travelled outside of France was hospitalized for a first episode of acute heart failure revealing an atypical appearance of the left ventricle. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319822PMC

The attitude of kidney transplant recipients towards elective arteriovenous fistula ligation.

PLoS One 2020 2;15(7):e0234931. Epub 2020 Jul 2.

Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wrocław, Poland.

Background: Arteriovenous fistulas (AVF) are a source of various complications. Among previously hemodialyzed kidney transplant recipients (KTxR), the AVF may persist over time. The patients' decisions whether to ligate the functioning AVF may be prompted by many factors. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234931PLOS

Vaccination coverage of recommended vaccines and determinants of vaccination in at-risk groups.

Hum Vaccin Immunother 2020 Jul 2:1-8. Epub 2020 Jul 2.

Leuven University Vaccinology Center , Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.

Upon exposure to vaccine-preventable diseases, certain individuals are at increased risk for complications due to preexisting diseases, age or immunosuppressive treatment. Vaccination against influenza, pneumococcal disease and hepatitis B (for some groups) is advised in addition to standard vaccination against diphtheria, tetanus and pertussis. We estimated the vaccination coverage and determinants of recommended vaccinations in patients with diabetes mellitus type 1 (n = 173) and type 2 (n = 177), chronic kidney disease (CKD) (n = 138), heart failure (n = 200), chronic obstructive pulmonary disease (COPD) (n = 187), HIV (n = 201) or solid organ transplantation (SOT) (n = 201) in a monocentric study. Read More

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http://dx.doi.org/10.1080/21645515.2020.1763739DOI Listing

Solid Organ Transplantation During the COVID-19 Pandemic.

Front Immunol 2020 16;11:1392. Epub 2020 Jun 16.

Department of Kidney Transplantation, The Second Xiangya Hospital of Central South University, Changsha, China.

Since December 2019, the ongoing coronavirus disease 2019 (COVID-19) pandemic has significantly affected solid organ transplantation (SOT) worldwide and has become a threat to the lives of SOT recipients. Here, we have reviewed, condensed, and organized the available information on COVID-19 to provide recommendations to transplant healthcare workers. Our review of reported cases shows that the symptoms of SOT patients with COVID-19 are similar to those of the normal population, but their severity and outcomes are worse. Read More

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http://dx.doi.org/10.3389/fimmu.2020.01392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308422PMC

The biological age of the heart is consistently younger than chronological age.

Sci Rep 2020 Jul 1;10(1):10752. Epub 2020 Jul 1.

Lifelab Program, Consorzio Per La Ricerca Sanitaria-CORIS, Veneto Region, Via Giustiniani 2, 35128, Padua, Italy.

Chronological age represents the main factor in donor selection criteria for organ transplantation, however aging is very heterogeneous. Defining the biological aging of individual organs may contribute to supporting this process. In this study we examined the biological age of the heart [right (RA)/left atrium (LA)] and peripheral blood leucocytes in the same subject, and compared these to assess whether blood mirrors cardiac biological aging. Read More

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http://dx.doi.org/10.1038/s41598-020-67622-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329913PMC

Heterotopic Porcine Cardiac Xenotransplantation in the Intra-Abdominal Position in a Non-Human Primate Model.

Sci Rep 2020 Jul 1;10(1):10709. Epub 2020 Jul 1.

University of Maryland School of Medicine, Department of Surgery, Baltimore, MD, USA.

Heterotopic cardiac transplantation in the intra-abdominal position in a large animal model has been essential in the progression of the field of cardiac transplantation. Our group has over 10 years of experience in cardiac xenotransplantation with pig to baboon models, the longest xenograft of which survived over 900 days, with rejection only after reducing immunosuppression. This article aims to clarify our approach to this model in order to allow others to share success in long-term survival. Read More

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http://dx.doi.org/10.1038/s41598-020-66430-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329828PMC

Cardiopulmonary exercise testing in chronic heart failure patients treated with beta-blockers: Still a valid prognostic tool.

Int J Cardiol 2020 Apr 11. Epub 2020 Apr 11.

Heart Failure Unit, Cardiology Department, Polichirurgico Hospital G. Da Saliceto, Piacenza, Italy.

Background: The advent of beta-blockers (BBs) has revolutionized the treatment of heart failure due to left ventricular dysfunction (HFrEF), as these drugs increase survival and reduce hospitalization without a significant impact on exercise tolerance. In this new prognostic scenario, the predictive role of cardiopulmonary exercise testing (CPET) has been questioned.

Aim: To evaluate the predictive value of CPET and "traditional" derived and calculated risk parameters in HFrEF patients on BBs. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.04.020DOI Listing

Regression of Atherosclerosis in ApoE-/- Mice Via Modulation of Monocyte Recruitment and Phenotype, Induced by Weekly Dosing of a Novel "Cytotopic" Anti-Thrombin Without Prolonged Anticoagulation.

J Am Heart Assoc 2020 Jul 2;9(13):e014811. Epub 2020 Jul 2.

Department of Inflammation Biology School of Immunology and Microbial Sciences King's College London, Guy's Hospital London United Kingdom.

Background Anticoagulants induce atherosclerosis regression in animal models but exploiting this clinically is limited by bleeding events. Here we test a novel thrombin inhibitor, PTL060, comprising hirulog covalently linked to a synthetic myristoyl electrostatic switch to tether to cell membranes. Methods and Results ApoE-/- mice were fed chow or high-fat diets, before transplantation of congenic aortic segments or injection of PTL060, parental hirulog, control saline, or labeled CD11b positive cells. Read More

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http://dx.doi.org/10.1161/JAHA.119.014811DOI Listing

Plant-Dominant Low-Protein Diet for Conservative Management of Chronic Kidney Disease.

Nutrients 2020 06 29;12(7). Epub 2020 Jun 29.

Division of Nephrology, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA.

Chronic kidney disease (CKD) affects >10% of the adult population. Each year, approximately 120,000 Americans develop end-stage kidney disease and initiate dialysis, which is costly and associated with functional impairments, worse health-related quality of life, and high early-mortality rates, exceeding 20% in the first year. Recent declarations by the World Kidney Day and the U. Read More

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http://dx.doi.org/10.3390/nu12071931DOI Listing
June 2020
3.148 Impact Factor

Chagas Disease Infection Reactivation after Heart Transplant.

Trop Med Infect Dis 2020 Jun 29;5(3). Epub 2020 Jun 29.

Department of Surgery, School of Medicine, Federal University of Minas Gerais (UFMG), Av. Alfredo Balena 190, Belo Horizonte CEP 30130-110, MG, Brazil.

Chagas disease, caused by a infection, is one of the main causes of heart failure in Latin America. It was originally a health problem endemic to South America, predominantly affecting residents of poor rural areas. With globalization and increasing migratory flows from these areas to large cities, the immigration of chronically-infected people to developed, non-endemic countries has occurred. Read More

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http://dx.doi.org/10.3390/tropicalmed5030106DOI Listing

Post Heart Transplantation Coronary Artery Fistula and Coronary Artery Aneurysm Successfully Managed With the Implantation of Covered Stents.

J Invasive Cardiol 2020 Jul;32(7):E191-E192

Schulich Medicine & Dentistry Western University, London Health Sciences Centre, St. Joseph's Health Care, London, Canada.

Coronary-to-cardiac chamber fistulae and coronary aneurysms are potential complications after heart transplantation. In the setting of exercise intolerance and large fistulae at major coronary vessels, covered stents may provide an effective interventional strategy. Read More

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Heart and kidney transplant: should they be combined or subsequent?

ESC Heart Fail 2020 Jun 30. Epub 2020 Jun 30.

Department of Medicine, University of Wisconsin Hospital and Clinics, Madison, WI, USA.

Aims: End-stage heart failure patients often present with severe kidney failure and have limited treatment options. We compared the clinical characteristics and outcomes among end-stage heart and kidney failure patients who underwent combined heart and kidney transplant (HKTx) with those who underwent kidney transplant after heart transplant (KAH).

Methods And Results: All patients from 2007-2016 who underwent combined HKTx (n = 715) and those who underwent KAH (n = 130) using the United Network for Organ Sharing database were included. Read More

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http://dx.doi.org/10.1002/ehf2.12864DOI Listing

Combined amiodarone and digitalis therapy before heart transplantation is associated with increased post-transplant mortality.

ESC Heart Fail 2020 Jul 1. Epub 2020 Jul 1.

Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, Heidelberg, 69120, Germany.

Aims: Amiodarone and digitalis are frequently used drugs in patients with heart failure. Both have separately been linked to reduced post-transplant survival, but their combined impact on mortality after HTX remains uncertain. This study investigated the effects of combined amiodarone and digitalis use before HTX on post-transplant outcomes. Read More

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http://dx.doi.org/10.1002/ehf2.12807DOI Listing

Biventricular imaging markers to predict outcomes in non-compaction cardiomyopathy: a machine learning study.

ESC Heart Fail 2020 Jun 30. Epub 2020 Jun 30.

Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 44, São Paulo, 05403-000, Brazil.

Aims: Left ventricular non-compaction cardiomyopathy (LVNC) is a genetic heart disease, with heart failure, arrhythmias, and embolic events as main clinical manifestations. The goal of this study was to analyse a large set of echocardiographic (echo) and cardiac magnetic resonance imaging (CMRI) parameters using machine learning (ML) techniques to find imaging predictors of clinical outcomes in a long-term follow-up of LVNC patients.

Methods And Results: Patients with echo and/or CMRI criteria of LVNC, followed from January 2011 to December 2017 in the heart failure section of a tertiary referral cardiologic hospital, were enrolled in a retrospective study. Read More

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http://dx.doi.org/10.1002/ehf2.12795DOI Listing

Practical Considerations for Solid Organ Transplantation During the COVID-19 Global Outbreak: The Experience from Singapore.

Transplant Direct 2020 Jun 8;6(6):e554. Epub 2020 May 8.

Department of Infectious Diseases, Singapore General Hospital, Singapore.

The current coronavirus disease 2019 (COVID-19) pandemic has not only caused global social disruptions but has also put tremendous strain on healthcare systems worldwide. With all attention and significant effort diverted to containing and managing the COVID-19 outbreak (and understandably so), essential medical services such as transplant services are likely to be affected. Closure of transplant programs in an outbreak caused by a highly transmissible novel pathogen may be inevitable owing to patient safety. Read More

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http://dx.doi.org/10.1097/TXD.0000000000001002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266363PMC

Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine.

Int J Nanomedicine 2020 18;15:4205-4224. Epub 2020 Jun 18.

Department of Chemical Engineering, Northeastern University, Boston, MA 02115, United States.

Cardiovascular diseases are the number one cause of heart failure and death in the world, and the transplantation of the heart is an effective and viable choice for treatment despite presenting many disadvantages (most notably, transplant heart availability). To overcome this problem, cardiac tissue engineering is considered a promising approach by using implantable artificial blood vessels, injectable gels, and cardiac patches (to name a few) made from biodegradable polymers. Biodegradable polymers are classified into two main categories: natural and synthetic polymers. Read More

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http://dx.doi.org/10.2147/IJN.S245936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314574PMC

Transplanted stents: a case report.

BMC Cardiovasc Disord 2020 Jun 30;20(1):312. Epub 2020 Jun 30.

Department of Cardiac Surgery, Medical University Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Background: An optimal donor work-up to exclude preexisting conditions is recommended, but urgency and technical equipment in donor centers must be considered. We report a case of two coronary stents present in the donor heart and the related long-term outcome.

Case Presentation: A 59-year-old European male patient suffering from dilated cardiomyopathy with severely reduced left ventricular function and presenting with NYHA III underwent cardiac transplantation in 2004. Read More

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http://dx.doi.org/10.1186/s12872-020-01597-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325242PMC

Temporal trends and predictors of inhospital death in patients hospitalised for heart failure in Germany.

Eur J Prev Cardiol 2020 Jun 30:2047487320936020. Epub 2020 Jun 30.

Department of Cardiology, University Medical Center Mainz (Johannes Gutenberg-University Mainz), Germany.

Aims: We investigated trends in incidence, case fatality rate, patient characteristics and adverse inhospital events of patients hospitalised for heart failure in Germany.

Methods And Results: The German nationwide inpatient sample (2005-2016) was used for this analysis. Patients hospitalised due to heart failure were selected for analysis. Read More

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http://dx.doi.org/10.1177/2047487320936020DOI Listing

Correction to: A year in review in Minerva Anestesiologica 2019. Critical care.

Minerva Anestesiol 2020 Jun;86(6):688

Division of Anesthesia and General Intensive Care, Department of Medical, Surgical and Experimental Sciences, Sassari University Hospital, University of Sassari, Sassari, Italy, The originally published version of this article is available online at 10.23736/S0375-9393.20.14384-0.

This corrects the article DOI:10.23736/S0375-9393.20. Read More

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http://dx.doi.org/10.23736/S0375-9393.20.14856-9DOI Listing

Predicting Heart Rejection Using Histopathological Whole-Slide Imaging and Deep Neural Network with Dropout.

IEEE EMBS Int Conf Biomed Health Inform 2017 Feb 13;2017. Epub 2017 Apr 13.

Dept. of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332.

Cardiac allograft rejection is one major limitation for long-term survival for patients with heart transplants. The endomyocardial biopsy is one gold standard to screen heart rejection for patients that have heart transplantation. However, manual identification of heart rejection is expensive and time-consuming. Read More

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http://dx.doi.org/10.1109/bhi.2017.7897190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324296PMC
February 2017

Rapid resolution of colitis related to immunosuppressive medication after infliximab administration.

Pediatr Transplant 2020 Jun 30:e13754. Epub 2020 Jun 30.

Department of Pediatrics, Levine Children's Hospital, Charlotte, NC, USA.

Immunosuppression is necessary after solid organ transplantation. The non-infectious side effects associated with many of these agents are not well understood. We report a case of colitis, most resembling inflammatory bowel disease, that persisted despite withdrawal of tacrolimus and mycophenolate mofetil and transition to alternative agents. Read More

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http://dx.doi.org/10.1111/petr.13754DOI Listing

Immunosuppressant associated torsades de pointes after acute heart rejection in an 8-year-old boy.

Cardiol Young 2020 Jun 30:1-2. Epub 2020 Jun 30.

Department of Pediatrics, National Taiwan University Children's Hospital, Taipei, Taiwan.

Torsades de pointes is a kind of life-threatening ventricular tachyarrhythmia. We report a case of torsades de pointes in an 8-year-old boy with acute rejection after orthotopic heart transplantation. The causes of torsades de pointes could be either congenital or acquired. Read More

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http://dx.doi.org/10.1017/S1047951120001602DOI Listing

Identification of critical molecular pathways involved in exosome-mediated improvement of cardiac function in a mouse model of muscular dystrophy.

Acta Pharmacol Sin 2020 Jun 29. Epub 2020 Jun 29.

Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.

Duchenne muscular dystrophy (DMD) is a progressive disease characterized by skeletal muscle atrophy, respiratory failure, and cardiomyopathy. Our previous studies have shown that transplantation with allogeneic myogenic progenitor-derived exosomes (MPC-Exo) can improve cardiac function in X-linked muscular dystrophy (Mdx) mice. In the present study we explored the molecular mechanisms underlying this beneficial effect. Read More

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http://dx.doi.org/10.1038/s41401-020-0446-yDOI Listing

Bariatric surgery to achieve transplant in end-stage organ disease patients: A systematic review and meta-analysis.

Am J Surg 2020 Jun 13. Epub 2020 Jun 13.

University of Alabama at Birmingham Schools of Medicine, Department of Surgery, United States.

Background: As obesity prevalence grows, more end-stage organ disease patients will be precluded from transplant. Numerous reports suggest bariatric surgery in end-stage organ disease may help patients achieve weight loss sufficient for transplant listing.

Methods: We performed a systematic review/meta-analysis of studies of bariatric surgery to achieve solid organ transplant listing. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.04.041DOI Listing

Prognostic imaging biomarkers for diabetic kidney disease (iBEAt): study protocol.

BMC Nephrol 2020 Jun 29;21(1):242. Epub 2020 Jun 29.

Department of Imaging, Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.

Background: Diabetic kidney disease (DKD) remains one of the leading causes of premature death in diabetes. DKD is classified on albuminuria and reduced kidney function (estimated glomerular filtration rate (eGFR)) but these have modest value for predicting future renal status. There is an unmet need for biomarkers that can be used in clinical settings which also improve prediction of renal decline on top of routinely available data, particularly in the early stages. Read More

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http://dx.doi.org/10.1186/s12882-020-01901-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323369PMC

Clinical and Operative Determinants of Acute Kidney Injury after Cardiac Surgery.

Cardiorenal Med 2020 Jun 29:1-13. Epub 2020 Jun 29.

International Renal Research Institute of Vicenza, Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy.

Introduction: Cardiac surgery-associated acute kidney injury (CSA-AKI) is associated with increased morbidity and mortality.

Objectives: We aimed to identify potentially modifiable risk factors for CSA-AKI.

Methods: This was asingle-center retrospective cohort study of 495 adult patients undergoing cardiac surgery. Read More

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http://dx.doi.org/10.1159/000507777DOI Listing