Search our Database of Scientific Publications and Authors

I’m looking for a

    64184 results match your criteria Heart Transplantation

    1 OF 1284

    Biventricular Impella placement via complete venous access.
    Catheter Cardiovasc Interv 2017 May 22. Epub 2017 May 22.
    Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia.
    Impella (Abiomed, Danvers, MA) is an effective option for emergent treatment of critical refractory cardiogenic shock. However, in patients who have inadequate peripheral arterial access, Impella for left ventricular support sometimes requires surgical access, leading to disadvantages for emergent procedures or invasiveness for very sick patients. In addition, Impella for right ventricular support was recently reported to contribute to the management of severe biventricular dysfunction. Read More

    Inhaled pulmonary vasodilator therapy for management of right-ventricular dysfunction after left ventricular assist device placement and cardiac transplantation.
    Pharmacotherapy 2017 May 24. Epub 2017 May 24.
    Clinical Pharmacy Manager, Heart Transplant and Mechanical Circulatory Support; NewYork-Presbyterian Hospital, Columbia University Medical Center, Department of Pharmacy, New York, NY.
    Right ventricular failure (RVF) after cardiac transplant (CTX) or implantation of a continuous-flow left ventricular assist device (CF-LVAD) is associated with significant post-operative morbidity and mortality. A variety of modalities have been used to treat post-operative RVF, including management of volume status, intravenous inotropes and vasodilators, and right-sided mechanical support. Inhaled vasodilator agents are a unique treatment option aimed at minimizing systemic absorption by delivering therapy directly to the pulmonary vasculature. Read More

    7, 8, 3'-Trihydroxyflavone protects H/R-induced apoptosis and induces in vivo growth of human embryonic stem cell-derived cardiomyocytes.
    J Cell Biochem 2017 May 20. Epub 2017 May 20.
    Department of Cardiac Surgical lntensive Care Unit, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China.
    Background: Cellular therapy of human embryonic stem cell-derived cardiomyocytes (hES-CMs) holds great promise for regenerating infarcted cardiac tissues. Yet, the major challenge remains as little cells survived after grafting. In this study, we examined whether treating hES-CMs with 7, 8, 3'-Trihydroxyflavone (THF) may improve hES-CMs developments both in vitro and in vivo. Read More

    Low-flow/low-gradient aortic stenosis-Still a diagnostic and therapeutic challenge.
    Clin Cardiol 2017 May 23. Epub 2017 May 23.
    Department of Cardiology and Pneumology, University Medical Center Göttingen, Germany.
    Aortic stenosis (AS) is the most frequently observed valvular heart disease. During the symptomatic stage, the rate of death increases dramatically, so that a precise diagnostic approach is taken to guide therapeutic options. Of patients with severe AS, 30% to 50% present with low-flow/low-gradient AS (LF/LGAS) status. Read More

    Preoperative cardiac troponin level is associated with all-cause mortality of liver transplantation recipients.
    PLoS One 2017 23;12(5):e0177838. Epub 2017 May 23.
    Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    This study was aimed to evaluate the association between preoperative high-sensitivity cardiac troponin I (hs-cTnI) level and mortality in patients undergoing liver transplantation (LT). From January 2011 to May 2016, preoperative hs-cTnI level was measured in consecutive 487 patients scheduled for LT. Patients with elevated preoperative hs-cTnI were compared with those who had normal level. Read More

    The impact of multidisciplinary care on early morbidity and mortality after heart transplantation.
    Interact Cardiovasc Thorac Surg 2017 May 24. Epub 2017 May 24.
    Service de Cardiologie, Centre Hospitalier Universitaire Vaudois, Université de Lausanne, Lausanne, Switzerland.
    Objectives: The impact of multidisciplinary care on outcome after heart transplantation (HTx) remains unclear.

    Methods: This retrospective study investigates the impact of multidisciplinary care on the primary end point 1-year all-cause mortality (ACM) and the secondary end point mean acute cellular rejection (ACR) grade within the first postoperative year.

    Results: This study includes a total 140 HTx recipients (median age: 53. Read More

    Comparison of De Novo versus Upgrade Cardiac Resynchronization Therapy; Focused on the Upgrade for Pacing-Induced Cardiomyopathy.
    Yonsei Med J 2017 Jul;58(4):703-709
    Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Purpose: This study aimed to determine whether upgrade cardiac resynchronization therapy (CRT) shows better outcomes than de novo CRT. To do so, we compared the efficacy of CRT between de novo and upgrade groups, focusing particularly on the effect of upgrade CRT on patients with pacing-induced cardiomyopathy (PiCM).

    Materials And Methods: PiCM was defined as new-onset dilated cardiomyopathy following pacemaker implantation in patients with baseline normal ejection fraction ≥50%. Read More

    Medication self-management skills and cognitive impairment in older adults hospitalized for heart failure: A cross-sectional study.
    SAGE Open Med 2017 23;5:2050312117700301. Epub 2017 Mar 23.
    Section of Heart Failure and Cardiac Transplantation, Tomsich Family Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA.
    Background: Cognitive impairment is highly prevalent among older adults (aged ≥65 years) hospitalized for heart failure and has been associated with poor outcomes. Poor medication self-management skills have been associated with poor outcomes in this population as well. The presence and extent of an association between cognitive impairment and poor medication self-management skills in this population has not been clearly defined. Read More

    Functional consequences of RNA 5' terminal deletions on coxsackievirus B3 RNA replication and ribonucleoprotein complex formation.
    J Virol 2017 May 24. Epub 2017 May 24.
    Center for Virus Research and Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, CA, USA
    Group B coxsackieviruses are responsible for chronic cardiac infections. However, the molecular mechanisms by which the virus can persist in the human heart long after the signs of acute myocarditis have abated are still not completely understood. Recently, coxsackievirus B3 strains with 5' terminal deletions in genomic RNAs were isolated from a patient suffering from idiopathic dilated cardiomyopathy, suggesting that such mutant viruses may be the forms responsible for persistent infection. Read More

    BK virus as a mediator of graft dysfunction following kidney transplantation.
    Curr Opin Organ Transplant 2017 May 22. Epub 2017 May 22.
    aWeill Cornell Medical College, Department of Surgery, J.C. Walter Jr. Center for Transplantation, Houston Methodist Hospital bImmunobiology and Transplant Science Center, Department of Surgery, Houston Methodist Research Institute, Houston, Texas, USA.
    Purpose Of Review: BK virus is a significant risk factor for kidney allograft dysfunction and loss among renal transplant recipients. Currently, there is no proven effective treatment except for the reduction of immunosuppression. In this review, we discuss diagnostic challenges and current treatment options for BK in kidney transplant recipients. Read More

    Molecular Imaging of Acute Cardiac Transplant Rejection: Animal Experiments and Prospects.
    Transplantation 2017 May 19. Epub 2017 May 19.
    1 Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. 2 Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH).
    Acute rejection (AR) remains the biggest challenge during the 1st year after heart transplantation despite advances in immunosuppressive therapy. The early detection and curbing of AR are crucial to the survival of transplant recipients. However, as the gold standard for AR, endomyocardial biopsy has several limitations because of its inherent invasiveness and morbidity. Read More

    Characteristics of Clinically Diagnosed Pediatric Myocarditis in a Contemporary Multi-Center Cohort.
    Pediatr Cardiol 2017 May 23. Epub 2017 May 23.
    Pediatric Cardiology, Primary Children's Hospital, University of Utah, Salt Lake City, UT, USA.
    The objective of this study was to describe a contemporary cohort of pediatric patients hospitalized for clinically suspected myocarditis. A retrospective chart review was performed at seven tertiary pediatric hospitals. Electronic medical records were searched between 2008 and 2012 for patients ≤18 years admitted with an ICD-9 code consistent with myocarditis. Read More

    The Total Artificial Heart in End-Stage Congenital Heart Disease.
    Front Physiol 2017 9;8:131. Epub 2017 May 9.
    Cincinnati Children's Hospital Medical Center, Heart InstituteCincinnati, OH, USA.
    The development of durable ventricular assist devices (VADs) has improved mortality rates and quality of life in patients with end stage heart failure. While the use of VADs has increased dramatically in recent years, there is limited experience with VAD implantation in patients with complex congenital heart disease (CHD), despite the fact that the number of patients with end stage CHD has grown due to improvements in surgical and medical care. VAD use has been limited in patients with CHD and end stage heart failure due to anatomic (systemic right ventricle, single ventricle, surgically altered anatomy, valve dysfunction, etc. Read More

    Giant cell myocarditis presenting with acute heart failure.
    BMJ Case Rep 2017 May 22;2017. Epub 2017 May 22.
    University of Hull, Hull, UK.
    Idiopathic giant cell myocarditis (GCM) is a rare and rapidly progressing form of myocarditis predominantly affecting younger people. We report a case of a 23-year-old athletic patient who presented with features of acute heart failure due to GCM and discuss his management that included a left ventricular assist device as a bridge to transplant. He died immediately following the transplant. Read More

    Rationale and Design of a Clinical Trial to Evaluate the Safety and Efficacy of Intracoronary Infusion of Allogeneic Human CARdiac stEm Cells in Patients with Acute Myocardial Infarction and Left Ventricular Dysfunction: The Randomized Multicenter Double-Blind Controlled CAREMI Trial.
    Circ Res 2017 May 22. Epub 2017 May 22.
    Cardiology, Hospital General Universitario Gregorio Maranon
    Rationale: Stem cell therapy has increased the therapeutic armamentarium in the fight against ischemic heart disease and heart failure (HF). The administration of exogenous stem cells has been investigated in patients suffering an acute myocardial infarction (AMI) with the final aim of salvaging jeopardized myocardium and preventing left ventricular adverse remodeling and functional deterioration. However, phase I and II clinical trials with autologous and "first-generation" stem cells have yielded inconsistent benefits and mixed results. Read More

    Towards the goal of achieving a normal duration and quality of life after Fontan operation: Creation of the International Fontan Interest group (I-FIG), an international collaborative initiative dedicated to improving outcomes.
    Int J Cardiol 2017 May 11. Epub 2017 May 11.
    Fetal Heart Program, Children's Hospital of Philadelphia, Philadelphia, PA, USA. Electronic address:
    A growing population of patients are now surviving the Fontan procedure and face an uncertain future and a clear burden of disease. The best medical therapy and follow-up modalities for these patients have not yet been identified, indications for transplantation are unclear and we have not been successful in mechanically supporting their circulation. There has only been a limited number of trials to address these issues. Read More

    Combined pulmonary and left ventricular support with veno-pulmonary ECMO and impella 5.0 for cardiogenic shock after coronary surgery.
    J Cardiothorac Surg 2017 May 22;12(1):38. Epub 2017 May 22.
    Department of Cardiothoracic Surgery, Zentrum Operative Medizine, University of Würzburg, Oberdürrbacher Str.6, 97080, Würzburg, Germany.
    Background: Mechanical circulatory support is a common practice nowadays in the management of patients after cardiogenic shock due to myocardial infarction. The single or combined use of one or more devices for mechanical support depends not only on the advantage or disadvantage of these devices but also on the timing of use of these devices before the development of multi organ failure. In our case we used more than one tool for mechanical circulatory support during the prolonged and complicated course of our patient with postcardiotomy cardiogenic shock after coronary artery bypass surgery. Read More

    Ventricular assist devices for the failing univentricular circulation.
    Expert Rev Med Devices 2017 May 22. Epub 2017 May 22.
    a Department of Cardiac Surgery , The Royal Children's Hospital , Melbourne.
    Introduction: Improved survival following single ventricle palliation has led to a large population of patients with a Fontan circulation, many of whom will eventually develop Fontan failure. Many of these patients will require heart transplantation. However, more than half of these patients have Fontan failure despite preserved ventricular function. Read More

    Naturally Engineered Maturation of Cardiomyocytes.
    Front Cell Dev Biol 2017 5;5:50. Epub 2017 May 5.
    Meinig School of Biomedical Engineering, Cornell UniversityIthaca, NY, USA.
    Ischemic heart disease remains one of the most prominent causes of mortalities worldwide with heart transplantation being the gold-standard treatment option. However, due to the major limitations associated with heart transplants, such as an inadequate supply and heart rejection, there remains a significant clinical need for a viable cardiac regenerative therapy to restore native myocardial function. Over the course of the previous several decades, researchers have made prominent advances in the field of cardiac regeneration with the creation of in vitro human pluripotent stem cell-derived cardiomyocyte tissue engineered constructs. Read More

    Ventricular pacing in single ventricles-A bad combination.
    Heart Rhythm 2017 Jun;14(6):853-857
    Division of Pediatric Cardiology, Lucile Packard Children's Hospital, Stanford University, Palo Alto, California.
    Background: Chronic ventricular pacing (VP) is associated with systolic dysfunction in a subset of pediatric patients with heart block and structurally normal hearts. The effect of chronic VP in congenital heart disease is less well understood, specifically in the single-ventricle (SV) population.

    Objective: To determine the longitudinal effect of VP in SV patients. Read More

    Expansion and Purification Are Critical for the Therapeutic Application of Pluripotent Stem Cell-Derived Myogenic Progenitors.
    Stem Cell Reports 2017 May 18. Epub 2017 May 18.
    Department of Medicine, Lillehei Heart Institute, University of Minnesota, 4-128 CCRB, 2231 6th Street South East, Minneapolis, MN 55455, USA. Electronic address:
    Recent reports have documented the differentiation of human pluripotent stem cells toward the skeletal myogenic lineage using transgene- and cell purification-free approaches. Although these protocols generate myocytes, they have not demonstrated scalability, safety, and in vivo engraftment, which are key aspects for their future clinical application. Here we recapitulate one prominent protocol, and show that it gives rise to a heterogeneous cell population containing myocytes and other cell types. Read More

    Impact of High-Priority Allocation on Lung and Heart-Lung Transplantation for Pulmonary Hypertension.
    Ann Thorac Surg 2017 May 18. Epub 2017 May 18.
    University Paris-Sud, Faculté de Médecine, Université-Paris-Saclay, Le Kremlin-Bicêtre; INSERM UMR_999, Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson; Department of Thoracic and Vascular Surgery and Heart-Lung Transplantation, Hôpital Marie-Lannelongue, Le Plessis Robinson, Paris-Sud University, Paris, France.
    Background: Since 2006 and 2007, patients in France with severe pulmonary hypertension (PH) who are at imminent risk of death, despite optimal treatment in the intensive care unit, are placed on a high-priority list (HPL) for heart-lung transplantation (HLT) or double-lung transplantation (DLT). We assessed the effect of this approach on the waiting list and outcomes after transplantation.

    Methods: We conducted a single-center, retrospective, before-and-after study of consecutive patients with severe group 1, 1', or 4 PH listed for DLT or HLT between 2000 and 2013 (ie, 6 years before and 6 years after HPL implementation). Read More

    Resolution of Mitral Regurgitation With Left Ventricular Assist Device Support.
    Ann Thorac Surg 2017 May 17. Epub 2017 May 17.
    Division of Cardiothoracic Transplantation and Circulatory Support, Texas Heart Institute, Baylor College of Medicine, Houston, Texas.
    Background: Cardiac valve disease is common in patients with end-stage heart failure undergoing left ventricular assist device implantation (LVAD). The aim of this study was to determine if preoperative mitral regurgitation (MR) affects outcomes and hemodynamics in patients after LVAD implantation.

    Methods: From March 2006 through May 2015, 238 consecutive patients underwent LVAD implantation. Read More

    Evaluation of the SIPAT instrument to assess psychosocial risk in heart transplant candidates: A retrospective single center study.
    Heart Lung 2017 May 17. Epub 2017 May 17.
    Department of Medicine, Division of Cardiology, University of California Los Angeles, 100 Medical Plaza, Suite 630E, Los Angeles, CA, 90095, USA.
    Objectives: We evaluated the reliability of the Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT) in heart transplant (HT) recipients and explored its usefulness in predicting post-transplant outcomes.

    Background: Pre-transplant psychosocial and behavioral risk is associated with post-transplant clinical outcomes. SIPAT is a risk assessment tool created for pre-transplant psychosocial evaluation. Read More

    CCN3 Regulates Macrophage Foam Cell Formation and Atherosclerosis.
    Am J Pathol 2017 Jun;187(6):1230-1237
    Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio; Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio. Electronic address:
    Recent studies implicate the Cyr61, CTGF, Nov (CCN) matricellular signaling protein family as emerging players in vascular biology, with NOV (alias CCN3) as an important regulator of vascular homeostasis. Herein, we examined the role of CCN3 in the pathogenesis of atherosclerosis. In response to a 15-week high-fat diet feeding, CCN3-deficient mice on the atherosclerosis-prone Apoe(-/-) background developed increased aortic lipid-rich plaques compared to control Apoe(-/-) mice, a result that was observed in the absence of alterations in plasma lipid content. Read More

    Cytomorphology review of 100 newly diagnosed lower-risk MDS patients in the European LeukemiaNet MDS (EUMDS) registry reveals a high inter-observer concordance.
    Ann Hematol 2017 May 20. Epub 2017 May 20.
    Department of Haematology, Oncology and Clinical Immunology, Universitätsklinik Düsseldorf, Düsseldorf, Germany.
    The European LeukemiaNet MDS (EUMDS) registry is collecting data of myelodysplastic syndrome (MDS) patients belonging to the IPSS low or intermediate-1 category, newly diagnosed by local cytologists. The diagnosis of MDS can be challenging, and some data report inter-observer variability with regard to the assessment of the MDS subtype. In order to ensure that correct diagnoses were made by the participating centres, blood and bone marrow slides of 10% of the first 1000 patients were reviewed by an 11-person panel of cytomorphologists. Read More

    Thyroid hormone biosynthesis machinery is altered in the ischemic myocardium: An epigenomic study.
    Int J Cardiol 2017 May 11. Epub 2017 May 11.
    Cardiocirculatory Unit, Health Research Institute of La Fe University Hospital (IIS La Fe), Valencia, Spain. Electronic address:
    Background: Abnormal thyroid hormone (TH) metabolism is significantly associated with impaired left ventricular (LV) function and death. Although TH was traditionally thought to be produced exclusively by the thyroid gland, an increasing number of studies report TH production in other tissues. Based on these findings, we evaluated whether the genes required for TH biosynthesis are expressed in the human heart, and whether their expression is altered in patients with ischemic cardiomyopathy (ICM) and is related to epigenetic variations. Read More

    Pulmonary function tests do not predict mortality in patients undergoing continuous-flow left ventricular assist device implantation.
    J Thorac Cardiovasc Surg 2017 Apr 11. Epub 2017 Apr 11.
    Division of Cardiothoracic Surgery, University of Washington Medical Center, Seattle, Wash.
    Objectives: To investigate the effect of pulmonary function testing on outcomes after continuous flow left ventricular assist device implantation.

    Methods: A total of 263 and 239 patients, respectively, had tests of forced expiratory volume in 1 second and diffusing capacity of the lungs for carbon monoxide preoperatively for left ventricular assist device implantations between July 2005 and September 2015. Kaplan-Meier analysis and multivariable Cox regressions were performed to evaluate mortality. Read More

    Transplantation of human villous trophoblasts preserves cardiac function in mice with acute myocardial infarction.
    J Cell Mol Med 2017 May 19. Epub 2017 May 19.
    Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
    Over the past decade, cell therapies have provided promising strategies for the treatment of ischaemic cardiomyopathy. Particularly, the beneficial effects of stem cells, including bone marrow stem cells (BMSCs), endothelial progenitor cells (EPCs), mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs), have been demonstrated by substantial preclinical and clinical studies. Nevertheless stem cell therapy is not always safe and effective. Read More

    Progress in the Presence of Failure: Updates in Chronic Systolic Heart Failure Management.
    Curr Treat Options Cardiovasc Med 2017 Jul;19(7):50
    Mayo Clinic Phoenix, 5777 East Mayo Blvd, Phoenix, AZ, 85054, USA.
    Opinion Statement: The therapeutic heart failure armamentarium has evolved from drugs to transplantation to devices through further understanding of its complex pathophysiology and pathogenesis. Current medications capitalize on our evolving understanding of the sympathetic and renin-angiotensin-aldosterone systems that subsequently promote both beneficial and maladaptive responses that ultimately yield a decrease in cardiac function. Despite these advancements, the prevalence of heart failure continues to rise and carries a significant burden on our patients and health care system. Read More

    Splenic abcesses as infectious complication following implantation of left ventricular asssist device - case report.
    Pol Przegl Chir 2017 Feb;89(1):61-65
    Klinika Chirurgii Ogólnej, Onkologicznej i Metabolicznej, Instytut Hematologii i Transfuzjologii w Warszawie Kierownik: prof. dr hab. Andrzej B. Szczepanik.
    Left ventricular assist device (LVAD) is one of the modern management therapies in patients with advanced heart failure, and it serves as a bridge to heart transplantation or even as destination therapy. However, it is burdened with a high risk of thromboembolic, hemorrhagic, and infectious complications despite prophylactic management. Splenic abscesses, as septic complications following implantation of mechanical ventricular support, have not yet been described in the literature. Read More

    High pre-ischemic fatty acid levels decrease cardiac recovery in an isolated rat heart model of donation after circulatory death.
    Metabolism 2017 Jun 15;71:107-117. Epub 2017 Mar 15.
    Department of Cardiovascular Surgery, Inselspital, Bern University Hospital, University of Bern, Switzerland. Electronic address:
    Rationale: Donation after circulatory death (DCD) could improve cardiac graft availability. However, strategies to optimize cardiac graft recovery remain to be established in DCD; these hearts would be expected to be exposed to high levels of circulatory fat immediately prior to the inevitable period of ischemia prior to procurement.

    Objective: We investigated whether acute exposure to high fat prior to warm, global ischemia affects subsequent hemodynamic and metabolic recovery in an isolated rat heart model of DCD. Read More

    Mesenchymal Stem Cell Migration and Proliferation Are Mediated by Hypoxia-Inducible Factor-1α Upstream of Notch and SUMO Pathways.
    Stem Cells Dev 2017 May 18. Epub 2017 May 18.
    1 Regenerative Medicine and Heart Transplantation Unit, Instituto de Investigación Sanitaria La Fe , Valencia, Spain .
    Mesenchymal stem cells (MSCs) are effective in treating several pathologies. We and others have demonstrated that hypoxia or hypoxia-inducible factor 1 alpha (HIF-1α) stabilization improves several MSC functions, including cell adhesion, migration, and proliferation, thereby increasing their therapeutic potential. To further explore the mechanisms induced by HIF-1α in MSCs, we studied its relationship with Notch signaling and observed that overexpression of HIF-1α in MSCs increased protein levels of the Notch ligands Jagged 1-2 and Delta-like (Dll)1, Dll3, and Dll4 and potentiated Notch signaling only when this pathway was activated. Read More

    [Bipressil® : first single-pill combination of bisoprolol and perindopril arginine].
    Rev Med Liege 2017 May;72(5):260-265
    GIGA Cardiovascular Sciences, Heart Valve Clinic. Université de Liège.
    In patients suffering from systemic arterial hypertension, coronary artery disease, or heart failure, beta-blockers and angiotensin-convertase enzyme inhibitors play a major therapeutic and preventive role. Coronary artery disease remains the leading cause of mortality in industrialized countries. Unless adapted preventive strategy, notably pharmacological interventions, cardiovascular events in these patients remain high. Read More

    Role of Transient Receptor Potential Channels in Heart Transplantation: A Potential Novel Therapeutic Target for Cardiac Allograft Vasculopathy.
    Med Sci Monit 2017 May 18;23:2340-2347. Epub 2017 May 18.
    Department of Physiology, Dalian Medical University, Dalian, China (mainland).
    Heart transplantation has evolved as the criterion standard therapy for end-stage heart failure, but its efficacy is limited by the development of cardiac allograft vasculopathy (CAV), a unique and rapidly progressive form of atherosclerosis in heart transplant recipients. Here, we briefly review the key processes in the development of CAV during heart transplantation and highlight the roles of transient receptor potential (TRP) channels in these processes during heart transplantation. Understanding the roles of TRP channels in contributing to the key procedures for the development of CAV during heart transplantation could provide basic scientific knowledge for the development of new preventive and therapeutic approaches to manage patients with CAV after heart transplantation. Read More

    QT prolongation is associated with increased mortality in end stage liver disease.
    World J Cardiol 2017 Apr;9(4):347-354
    Sun Moon Kim, Bennet George, Brian Delisle, Yousef Darrat, Gustavo Morales, Samy-Claude Elayi, Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY 40509, United States.
    Aim: To determine the prevalence of QT prolongation in a large series of end stage liver disease (ESLD) patients and its association to clinical variables and mortality.

    Methods: The QT interval was measured and corrected for heart rate for each patient, with a prolonged QT cutoff defined as QT > 450 ms for males and QT > 470 ms for females. Multiple clinical variables were evaluated including sex, age, serum sodium, international normalized ratio, creatinine, total bilirubin, beta-blocker use, Model for End-Stage Liver Disease (MELD), MELD-Na, and etiology of liver disease. Read More

    Emergency HeartWare Ventricular Assist Device (HVAD) exchange due to pump thrombosis using minimally invasive technique.
    Kardiochir Torakochirurgia Pol 2017 Mar 31;14(1):76-78. Epub 2017 Mar 31.
    Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, SMDZ in Zabrze, Medical University of Silesia in Katowice, Silesian Centre for Heart Diseases, Zabrze, Poland.
    Left ventricular assist device (LVAD) thrombosis remains a dreadful complication of mechanical circulatory support, with an incidence of 8-12% depending on the pump type and patient's comorbidities. Fibrinolysis may be considered early in pump thrombosis, but when contraindicated a pump exchange remains the only alternative. This short report documents an emergency LVAD exchange in a 55-year-old man who underwent LVAD (HeartWare Inc) implantation in 2013 as a bridge to transplantation. Read More

    Ischaemic preconditioning - Current knowledge and potential future applications after 30 years of experience.
    Adv Med Sci 2017 May 13;62(2):307-316. Epub 2017 May 13.
    Intensive Cardiac Therapy Clinic, Department of Invasive Cardiology and Electrocardiology, Medical University, Lodz, Poland.
    Ischaemic preconditioning (IPC) phenomenon has been known for thirty years. During that time several studies showed that IPC provided by brief ischaemic and reperfusion episodes prior to longer ischaemia can bestow a protective effect to both preconditioned and also remote organs. IPC affecting remote organs is called remote ischaemic preconditioning. Read More

    Propofol-based anaesthesia versus sevoflurane-based anaesthesia for living donor kidney transplantation: results of the VAPOR-1 randomized controlled trial.
    Br J Anaesth 2017 May;118(5):720-732
    Department of Anaesthesiology.
    Background: Kidney transplantation is associated with harmful processes affecting the viability of the graft. One of these processes is associated with the phenomenon of ischaemia-reperfusion injury. Anaesthetic conditioning is a widely described strategy to attenuate ischaemia-reperfusion injury. Read More

    Epicardial cardioverter-defibrillator implantation in a 4-month-old infant bridged to heart transplantation.
    Interact Cardiovasc Thorac Surg 2017 May 16. Epub 2017 May 16.
    Pediatric Cardiology Unit, Grande Ospedale Metropolitano Niguarda, Milan, Italy.
    Implantable cardioverter-defibrillator (ICD) is the gold standard therapy for the prevention of sudden cardiac death. Nevertheless, ICD placement in the paediatric population is still limited because of several technical difficulties. Several implantation techniques have been proposed but experience in infants with very low weight and less than 6 months is very limited. Read More

    Report from the American society of transplantation conference on donor heart selection in adult cardiac transplantation in the U.S.
    Am J Transplant 2017 May 16. Epub 2017 May 16.
    University of Utah, Salt Lake City, Utah.
    Cardiac transplantation remains the only definitive treatment for end-stage heart failure. Transplantation rates are limited by a shortage of donor hearts. This shortage is magnified because many hearts are discarded due to strict selection criteria and concern for regulatory reprimand for less than optimal post-transplant outcomes. Read More

    Application of Decellularized Tissue Scaffolds in Ovarian Tissue Transplantation.
    Methods Mol Biol 2017 May 17. Epub 2017 May 17.
    Innovation Institute for Fertility Preservation and In Vitro Fertilization, New York, NY, USA.
    In tissue engineering, decellularized scaffolds have been proved to have remarkable capacity to promote regeneration in various organs such as kidney, heart, lung, and liver. Marrying the field of cryobiology and reproductive medicine resulted in considerable progress and breakthroughs, which led to the emergence of ovarian tissue cryopreservation and transplantation as a promising option for fertility preservation. Here we describe an innovative application of decellularized tissue scaffolds as a regenerative platform for reconstruction of ovarian grafts for auto-transplantation. Read More

    Adaptive Pump Speed Algorithms to Improve Exercise Capacity in Patients Supported with a Left-Ventricular Assist Device.
    Stud Health Technol Inform 2017 ;236:235-240
    OFFIS - Institute for Information Technology, Oldenburg, Germany.
    For the treatment of terminal heart failure, the therapy with left-ventricular assist devices has already been established. In the systems used today, pump speed does not adjust during physical activity so that cardiac output and exercise capacity remain markedly limited. It is the aim of this study to develop an automatic pump speed control based on filling pressure values in order to improve exercise capacity and quality of life in these patients. Read More

    Should subcutaneous implantable cardioverter-defibrillators be implanted in patients who are candidates for continuous flow left ventricular assist device?
    Eur J Intern Med 2017 May 12. Epub 2017 May 12.
    Cardiac Surgery and Heart Transplantation Unit, Department for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), Palermo, Italy.

    Mitral Regurgitation Grading in the Operating Room: A Systematic Review and Meta-analysis Comparing Preoperative and Intraoperative Assessments During Cardiac Surgery.
    J Cardiothorac Vasc Anesth 2017 Feb 13. Epub 2017 Feb 13.
    Department of Anesthesia and Intensive Care, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), Palermo, Italy.
    Objective: To assess differences in mitral regurgitation (MR) grade between the preoperative and the intraoperative evaluations.

    Design: Systematic review and meta-analysis of 6 observational studies found from MEDLINE and EMBASE.

    Setting: Cardiac surgery. Read More

    1 OF 1284