1,407,962 results match your criteria Heart Surgery Forum[Journal]


Ski Mountaineering - Evaluation of a Sports Specific Performance Diagnosis.

Sportverletz Sportschaden 2018 Dec 11;32(4):233-242. Epub 2018 Dec 11.

SozialStiftung Bamberg, Sports Orthopedics, Bamberg.

Ski mountaineering (skimo) has recently gained popularity and established itself as a competition sport. It requires a specific training with a high hypoxic load. Although a variety of sport specific performance test protocols have been developed, a specific method for ski mountaineering (skimo) is pending. Read More

View Article
December 2018
2 Reads

The Influence of Sleep Apnea on 24-hour and Nocturnal ECG and Blood Pressure Parameters in Patients with Acute Heart Failure.

Med Princ Pract 2018 Dec 11. Epub 2018 Dec 11.

Objective: To investigate the influence of sleep apnea on ECG and blood pressure monitoring parameters in patients with acute heart failure (AHF).

Methods: 51 hospitalized patients with AHF (13 women, 38 men, mean age 60.8 years) underwent 24-hour combined monitoring of ECG and blood pressure and sleep apnea testing before discharge. Read More

View Article
December 2018
1 Read

Renal Functions and Prognosis Stratification in Chronic Heart Failure Patients and the Importance of Neutrophil Gelatinase-Associated Lipocalin.

Kidney Blood Press Res 2018 Dec 7;43(6):1865-1877. Epub 2018 Dec 7.

Department of Internal Cardiology Medicine, Faculty Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Background/aims: The rate of incidence and prevalence of acute kidney injury is increasing due to an increased number of patients with heart failure. Therefore it is very pertinent to early detect the level of renal injuries and to make necessary heart failure predictions. Thus the aim of this study is to determine renal functions and prognosis stratification in chronic heart failure patients and importance of Neutrophil Gelatinase-Associated Lipocalin (NGAL), an early diagnostic marker of acute kidney injury, as well as stratification of cardiovascular risk in heart failure patients. Read More

View Article
December 2018

Nomogram Model to Predict Cardiorenal Syndrome Type 1 in Patients with Acute Heart Failure.

Kidney Blood Press Res 2018 Dec 7;43(6):1832-1841. Epub 2018 Dec 7.

Background/aims: Cardiorenal syndrome type 1(CRS1) is a serious clinical condition in patients with acute heart failure (AHF) associated with adverse clinical outcomes. Although several biomarkers for identifying CRS1 have been reported, early and accurate predicting CRS1 still remains a challenge. This study was aimed to develop and validate an individualized predictive nomogram for the risk of CRS1 in patients with AHF. Read More

View Article
December 2018

Cardiovascular toxicity and anxiety-like behavior induced by deltamethrin in zebrafish (Danio rerio) larvae.

Chemosphere 2018 Dec 5;219:155-164. Epub 2018 Dec 5.

State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin, 300071, China. Electronic address:

Deltamethrin is widely used because of its low toxicity and high efficiency. Although its potential toxicity has been reported, its effects on cardiovascular system and motor behavior and its underlying mechanisms have remained unclear. In this study, the effects of deltamethrin on the development, cardiovascular system and motor behavior of zebrafish larvae and their possible mechanisms were evaluated using the transgenic zebrafish Tg (kdrl:mCherry) and Tg(myl7:GFP). Read More

View Article
December 2018

Health utility scores of atopic dermatitis in US adults.

J Allergy Clin Immunol Pract 2018 Dec 8. Epub 2018 Dec 8.

Oregon Health & Science University, Portland, OR.

Background: The impact of atopic dermatitis (AD) on health related quality of life and health utility in the United States adult population is not well-established.

Objectives: To determine the health utilities and quality of life adjusted years (QALYs) lost in adults with vs. without AD among the US population. Read More

View Article
December 2018
1 Read

Developing a quality standard for verbal communication during CABG procedures.

Semin Thorac Cardiovasc Surg 2018 Dec 8. Epub 2018 Dec 8.

Department of Cardio-Thoracic Surgery, Leiden University Medical Center, Leiden.

Objective: Verbal communication during coronary artery bypass graft (CABG) procedures is essential for safe and efficient cardiac surgery, yet sensitive to failure due to a current lack of standardization. The goal of this study was to improve communication during CABG by identifying critical items in verbal interaction between surgeons, anesthetists and perfusionists.

Methods: Based on 6 video recordings, a list was assembled containing items of communication in CABG procedures. Read More

View Article
December 2018

Elevated resting blood pressure augments autonomic imbalance in posttraumatic stress disorder.

Am J Physiol Regul Integr Comp Physiol 2018 Dec 10;315(6):R1272-R1280. Epub 2018 Oct 10.

Renal Division, Department of Medicine, Emory University School of Medicine , Atlanta, Georgia.

Posttraumatic stress disorder (PTSD) is characterized by increased sympathetic nervous system (SNS) activity, blunted parasympathetic nervous system (PNS) activity, and impaired baroreflex sensitivity (BRS), which contribute to accelerated cardiovascular disease. Patients with PTSD also have chronic stress-related elevations in resting blood pressure (BP), often in the prehypertensive range; yet, it is unclear if elevated resting blood pressure (ERBP) augments these autonomic derangements in PTSD. We hypothesized that compared with normotensive PTSD (N-PTSD), those with ERBP (E-PTSD) have further increased SNS, decreased PNS activity, and impaired BRS at rest and exaggerated SNS reactivity, PNS withdrawal, and pressor responses during stress. Read More

View Article
December 2018

Differentiation of Human-Induced Pluripotent Stem Cells to Macrophages for Disease Modeling and Functional Genomics.

Curr Protoc Stem Cell Biol 2018 Dec 10:e74. Epub 2018 Dec 10.

Cardiometabolic Genomics Program, Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, New York.

Macrophages play important roles in many diseases. We describe a protocol and the associated resources for the differentiation of human induced pluripotent stem cell-derived macrophages (IPSDM) and their applications in understanding human macrophage physiology and relevant diseases. The protocol uses an embryoid body-based approach with a combination of serum-free condition for hematopoiesis specification, followed by adherent culture with serum and M-CSF for myeloid expansion and macrophage maturation. Read More

View Article
December 2018

Toward a solution for cardiac failure in the newborn.

Xenotransplantation 2018 Dec 11:e12479. Epub 2018 Dec 11.

Department of Surgery and Department of Microbiology & Immunology, University of Michigan, Ann Arbor, Michigan.

The newborn infant with severe cardiac failure owed to congenital structural heart disease or cardiomyopathy poses a daunting therapeutic challenge. The ideal solution for both might be cardiac transplantation if availability of hearts was not limiting and if tolerance could be induced, obviating toxicity of immunosuppressive therapy. If one could safely and effectively exploit neonatal tolerance for successful xenotransplantation of the heart, the challenge of severe cardiac failure in the newborn infant might be met. Read More

View Article
December 2018

Initial results from the off-label use of the SAPIEN S3 valve for percutaneous transcatheter pulmonary valve replacement: A multi-institutional experience.

Catheter Cardiovasc Interv 2018 Dec 7. Epub 2018 Dec 7.

Department of Pediatrics, Division of Cardiology, UCLA Mattel Children's Hospital, Los Angeles, California.

Objectives: To describe a multi-center experience of percutaneous transcatheter pulmonary valve replacement (TPVR) using the Edwards Sapien S3 Valve.

Background: Off-label use of the Sapien S3 valve can allow for TPVR in patients with congenital heart disease (CHD) and large diameter dysfunctional right ventricular outflow tract (RVOT). The initial experience at five centers with the SAPIEN S3 valve for TPVR is presented with a focus on procedural techniques, success, complications, and efficacy. Read More

View Article
December 2018

Multiple receptors converge on H2-Q10 to regulate NK & γδT cell development.

Immunol Cell Biol 2018 Dec 9. Epub 2018 Dec 9.

Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Australia.

Class Ib MHC are an extended family of molecules which demonstrate tissue-specific expression and presentation of monomorphic antigens. These characteristics tend to imbue class Ib MHC with unique functions. H2-Q10 is potentially one such molecule in that it is overexpressed in the liver but its immunological function is not known. Read More

View Article
December 2018

Physical activity energy expenditure and cardiometabolic health in three rural Kenyan populations.

Am J Hum Biol 2018 Dec 10:e23199. Epub 2018 Dec 10.

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.

Objectives: Physical activity is beneficial for metabolic health but the extent to which this may differ by ethnicity is still unclear. Here, the objective was to characterize the association between physical activity energy expenditure (PAEE) and cardiometabolic risk among the Luo, Kamba, and Maasai ethnic groups of rural Kenya.

Methods: In a cross-sectional study of 1084 rural Kenyans, free-living PAEE was objectively measured using individually-calibrated heart rate and movement sensing. Read More

View Article
December 2018

The prognostic value of troponin T and N-terminal pro B-type natriuretic peptide, alone and in combination, in heart failure patients with and without diabetes.

Eur J Heart Fail 2018 Dec 10. Epub 2018 Dec 10.

BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.

Aims: We examined the prognostic importance of N-terminal pro B-type natriuretic peptide (NT-proBNP) and troponin T (TnT) in heart failure patients with and without diabetes.

Methods And Results: We measured NT-proBNP and TnT in the biomarker substudy of the Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure trial (PARADIGM-HF). Of 1907 patients, 759 (40%) had diabetes. Read More

View Article
December 2018
1 Read

Can advanced analytics fix modern medicine's problem of uncertainty, imprecision, and inaccuracy?

Eur J Heart Fail 2018 Dec 10. Epub 2018 Dec 10.

Health Data Research UK and Institute of Health Informatics, University College London, London, UK.

View Article
December 2018

Angiosarcoma of the right atrium with extension to the superior and inferior vena cavae.

J Card Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiac Surgery, Kerckhoff-Heart Center Bad Nauheim, Bad Nauheim, Germany.

View Article
December 2018

Exercise worsening of electromechanical disturbances: a predictor of arrhythmia in long qt syndrome.

Clin Cardiol 2018 Dec 9. Epub 2018 Dec 9.

Institute of Public Health and Clinical Medicine, Umea University, Umea, Sweden.

Background: Electromechanical (EM) coupling heterogeneity is significant in long QT syndrome (LQTS), particularly in symptomatic patients; EM window (EMW) has been proposed as an indicator of interaction and a better predictor of arrhythmia than QTc.

Aim: To investigate the dynamic response of EMW to exercise in LQTS and its predictive value of arrhythmia.

Methods: Forty-seven LQTS carriers (45±15 years, 20 with arrhythmic events) and 35 controls underwent exercise echocardiogram. Read More

View Article
December 2018
2 Reads

LL-37 and its analog FF/CAP18 attenuate neutrophil migration in sepsis-induced acute lung injury.

J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.

Department of Pulmonary and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Experimenter Center, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.

Introduction: Sepsis can result in acute lung injury. LL-37 is a small cationic host defense peptide involved in anti-inflammatory. In the current study, it was hypothesized that antimicrobial peptide LL-37 could play a protective role in attenuating the progression of sepsis-induced acute lung injury. Read More

View Article
December 2018

Medication dosing for heart failure with reduced ejection fraction - opportunities and challenges.

Eur J Heart Fail 2018 Dec 10. Epub 2018 Dec 10.

Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.

Multiple drug classes have shown incremental benefits in heart failure with reduced ejection fraction. Most of these trials were designed to achieve specific doses of the investigational agent. Clinical practice guidelines recommend using the same target dosing of therapies, as tolerated. Read More

View Article
December 2018

Impaired pressure natriuresis and non-dipping blood pressure in Rats with early type 1 diabetes mellitus.

J Physiol 2018 Dec 7. Epub 2018 Dec 7.

The British Heart Foundation Centre for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, United Kingdom, EH16 4TJ.

Key Points Summary: Type 1 diabetes mellitus increases cardiovascular risk: hypertension amplifies this risk. Pressure natriuresis regulates long-term blood pressure. We induced type 1 diabetes in rats by streptozotocin injection and after three weeks demonstrated a substantial impairment of pressure natriuresis: acute increases in blood pressure did not increase renal medullary blood flow, and tubular sodium reabsorption was not downregulated. Read More

View Article
December 2018

A Photoresponsive Hyaluronan Hydrogel Nanocomposite for Dynamic Macrophage Immunomodulation.

Adv Healthc Mater 2018 Dec 7:e1801234. Epub 2018 Dec 7.

Department of Mechanical and Aerospace Engineering, New York University, Brooklyn, NY, 11201, USA.

Macrophages are a predominant immune cell population that drive inflammatory responses and exhibit transitions in phenotype and function during tissue remodeling in disease and repair. Thus, engineering an immunomodulatory biomaterial has significant implications for resolving inflammation. Here, a biomimetic and photoresponsive hyaluronan (HA) hydrogel nanocomposite with tunable 3D extracellular matrix (ECM) adhesion sites for dynamic macrophage immunomodulation is engineered. Read More

View Article
December 2018

Effects of inhibitors of the renin-angiotensin system on reducing blood pressure and expression of inflammatory factors in CHD patients: A network meta-analysis.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

First Cadres Ward, The First Affiliated Hospital of PLA General Hospital, Beijing, China.

The renin-angiotensin system (RAS) is an ever-evolving endocrine system with considerable checks and balances on the production and catabolism of angiotensin peptides most likely due to the manifold effects of angiotensins. We aimed to explore the effects of different inhibitors of RAS on blood pressure and expression of inflammatory factors in patients with coronary heart disease (CHD). We initially searched PubMed, EMBASE and Cochrane Library electronic databases with nine eligible randomized controlled trials enrolled. Read More

View Article
December 2018
1 Read

Implantable cardiac defibrillators for people with non-ischaemic cardiomyopathy.

Cochrane Database Syst Rev 2018 Dec 8;12:CD012738. Epub 2018 Dec 8.

Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Background: There is evidence that implantable cardioverter-defibrillator (ICD) for primary prevention in people with an ischaemic cardiomyopathy improves survival rate. The evidence supporting this intervention in people with non-ischaemic cardiomyopathy is not as definitive, with the recently published DANISH trial finding no improvement in survival rate. A systematic review of all eligible studies was needed to evaluate the benefits and harms of using ICDs for primary prevention in people with non-ischaemic cardiomyopathy. Read More

View Article
December 2018

Remote monitoring of implantable cardioverter defibrillators: Patient experiences and preferences for follow-up.

Pacing Clin Electrophysiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.

Background: Patient satisfaction with remote patient monitoring (RPM) of implantable cardioverter defibrillators (ICDs) seems to be high, yet knowledge on long-term patient experiences is limited. The European REMOTE-CIED study explored patient experiences with RPM, examined patient preferences for ICD follow-up, and identified determinants of patient preferences in the first two years post-implantation.

Methods: European heart failure patients (N = 300; median age = 66 years (IQR = 59-73), and 22% female) with a first-time ICD received a Boston Scientific LATITUDE® RPM system and had scheduled in-clinic follow-ups once a year. Read More

View Article
December 2018

Cardio-renal protective effect of SGLT2 inhibitors and mitochondrial function.

Authors:
Hong Kyu Lee

J Diabetes Investig 2018 Dec 9. Epub 2018 Dec 9.

Department of Internal Medicine, Eulji University and Eulji General Hospital, Seoul, Republic of Korea.

Cardio-renal protective effect of Sodium Glucose Co-transporter-2 (SGLT2) inhibitors is well established by three large clinical trials; Empagliflozin, Cardiovascular Outcome Events Trial in Type 2 Diabetes Patients (EMPA-REG OUTCOME), Canagliflozin Cardiovascular Assessment Study (CANVAS), and most recently Dapagliflozin Effect on Cardiovascular Events Trial 58 by the Thrombolysis in Myocardial Infarction Study Group (DECLARE-TIMI 58). Three different SGLT2 inhibitors, empagliflozin, canagliflozin and dapagliflozin, were proven effective not only for their glucose lowering effect, but in reducing deterioration of renal function and prevented hospitalization due to heart failure. This article is protected by copyright. Read More

View Article
December 2018

Heart transplantation in two adolescents with Danon disease.

Pediatr Transplant 2018 Dec 7:e13335. Epub 2018 Dec 7.

Department of Pediatrics (Cardiology), Stanford University Medical Center, Stanford University, Stanford, California.

Danon disease (DD) is an X-linked dominant disorder caused by a mutation in the lysosomal-associated membrane protein-2 (LAMP-2) gene coding for the LAMP-2 protein. We report two cases of successful heart transplantation (HT) in adolescent brothers with DD, including one who was bridged to HT for 34 days with a HeartWare left ventricular assist device. In both patients, the post-transplant course was complicated by profound skeletal muscle weakness that resolved with corticosteroid withdrawal. Read More

View Article
December 2018

Pharmacotherapy for patent ductus arteriosus closure.

Authors:
John M Ferguson

Congenit Heart Dis 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.

Even though up to 60% of premature infants less than 28 weeks gestation develop persistent patent ductus arteriosus (PDA), there remains controversy regarding if, when, and how to close the PDA. Failure to close the PDA has been associated with significant morbidity but no cause-and-effect has been proven for short-term or long-term outcomes in modern times. Surgical closure has the advantage of eliminating the PDA, but short-term complications and long-term adverse outcomes are worrisome. Read More

View Article
December 2018

Transradial versus transfemoral percutaneous coronary intervention of left main disease: A systematic review and meta-analysis of observational studies.

Catheter Cardiovasc Interv 2018 Dec 10. Epub 2018 Dec 10.

Department of Medicine Division of Cardiology, North Shore University Hospital, Hofstra Northwell School of Medicine, New York.

Objectives: To assess the efficacy and safety of transradial (TR) versus transfemoral (TF) percutaneous coronary intervention (PCI) in left main (LM) lesion.

Background: TR-PCI is the preferred approach compared with TF approach because of less bleeding risk. LM-PCI is often challenging because of the anatomical complexity and uniqueness of supplying a large myocardium territory. Read More

View Article
December 2018

"Doc, I Think My Meds Are Killing Me! Please Help…": Transdisciplinary Forces Unite to Refocus Pharmacotherapy for Older Adults.

J Am Geriatr Soc 2018 Dec 7. Epub 2018 Dec 7.

Medical Officer, Geriatrics Branch, Division of Geriatrics and Clinical Gerontology, National Institute on Aging/National Institutes of Health.

View Article
December 2018

The Effect of Donor Alcohol Abuse on Outcomes Following Heart Transplantation.

Clin Transplant 2018 Dec 11:e13461. Epub 2018 Dec 11.

Loyola University Medical Center, Department of Cardiology.

Background: Current guidelines recommend against the use of hearts from donors that abuse alcohol. We explored the effect of donor alcohol abuse (AA) on cardiac allograft function and outcomes in heart transplant (HTx) recipients.

Methods: Overall, 370 HTx recipients were divided into two groups: (1) the alcoholic donor group (AD, n=58), and (2) the non-alcoholic donor group (NAD, n=312). Read More

View Article
December 2018

Body mass index and parasympathetic nervous system reactivity and recovery following graded exercise.

Am J Hum Biol 2018 Dec 10:e23208. Epub 2018 Dec 10.

Department of Psychology, The Ohio State University, Columbus, Ohio.

Objectives: The present study sought to expand upon prior investigations examining patterns of vagally mediated heart rate variability (vmHRV) and perceived exertion as a function of body mass index (BMI) in response to and recovery from exercise.

Methods: Participants underwent a resting (baseline) period, followed by a graded exercise protocol on an ergometer with ascending difficulty stages, and finally another resting (recovery) period. Individuals were stratified into three BMI groups: low, moderate, and high. Read More

View Article
December 2018

Pharmacotherapy in Older Adults with Cardiovascular Disease: Report from an American College of Cardiology, American Geriatrics Society, and National Institute on Aging Workshop.

J Am Geriatr Soc 2018 Dec 7. Epub 2018 Dec 7.

Cardiovascular Division, Department of Internal Medicine, Washington University, St. Louis, Missouri.

Objectives: To identify the top priority areas for research to optimize pharmacotherapy in older adults with cardiovascular disease (CVD).

Design: Consensus meeting.

Setting: Multidisciplinary workshop supported by the National Institute on Aging, the American College of Cardiology, and the American Geriatrics Society, February 6-7, 2017. Read More

View Article
December 2018

Comparison of phase-mapping and electrogram-based driver mapping for catheter ablation in atrial fibrillation.

Pacing Clin Electrophysiol 2018 Dec 10. Epub 2018 Dec 10.

Institute of Clinical Medicine, and Cardiovascular Research Center, National Yang-Ming University.

Introduction: Adjunctive driver-guided ablation in addition to pulmonary vein isolation has been proposed as a strategy to improve procedural success and outcomes for various populations with atrial fibrillation (AF). This study firstly aimed to evaluate the different mapping techniques for driver/rotor identification and secondly to evaluate the benefit of driver/rotor guided ablation in patients with paroxysmal and persistent AF.

Methods: We searched the electronic database in PubMed using the keywords "atrial fibrillation", "rotor", "rotational driver", "atrial fibrillation source", and "drivers" for both randomized controlled trials and observational controlled trials. Read More

View Article
December 2018

Heart failure with reduced ejection fraction: comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas.

Eur J Heart Fail 2018 Dec 10. Epub 2018 Dec 10.

British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.

Aims: Nearly 60% of the world's population lives in Asia but little is known about the characteristics and outcomes of Asian patients with heart failure with reduced ejection fraction (HFrEF) compared to other areas of the world.

Methods And Results: We pooled two, large, global trials, with similar design, in 13 174 patients with HFrEF (patient distribution: China 833, India 1390, Japan 209, Korea 223, Philippines 223, Taiwan 199 and Thailand 95, Western Europe 3521, Eastern Europe 4758, North America 613, and Latin America 1110). Asian patients were younger (55. Read More

View Article
December 2018
1 Read

LncRNA MALAT1 protects cardiomyocytes from isoproterenol-induced apoptosis through sponging miR-558 to enhance ULK1-mediated protective autophagy.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Henan Province People's Hospital, People's Hospital of Zhengzhou University, Fuwai Central China Cardiovascular Hospital Zhengzhou, Henan, China.

Investigating the molecular mechanisms of myocardial infarction (MI) and subsequent heart failure have gained considerable attention worldwide. Long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been previously demonstrated to regulate the proliferation and metastasis of several tumors. However, little is known about the effects of MALAT1 in MI and in regulating the cell date after MI. Read More

View Article
December 2018

Palbociclib plus endocrine therapy in HER2 negative, hormonal receptor-positive, advanced breast cancer: A real-world experience.

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Division of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Data from 423 human epidermal growth factor receptor 2-negative (HER2-), hormone receptor-positive (HR+) advanced breast cancer (aBC) patients treated with palbociclib and endocrine therapy (ET) were provided by 35 Italian cancer centers and analyzed for treatment outcomes. Overall, 158 patients were treated in first line and 265 in second/later lines. We observed 19 complete responses and 112 partial responses. Read More

View Article
December 2018
5 Reads

State of the art-Patent ductus arteriosus.

Authors:

Congenit Heart Dis 2018 Sep;13(5):645

View Article
September 2018

From the Chair of the AAP Section on Cardiology & Cardiac Surgery.

Authors:

Congenit Heart Dis 2018 Sep;13(5):877-878

View Article
September 2018

Abstracts.

Authors:

Congenit Heart Dis 2018 Sep;13(5):811-876

View Article
September 2018

Atrial fibrillation is highly prevalent yet undertreated in patients with biopsy-proven Nonalcoholic Steatohepatitis.

Liver Int 2018 Dec 7. Epub 2018 Dec 7.

Department of Preventive Medicine.

Background & Aims: Nonalcoholic steatohepatitis (NASH) is associated with increased cardiovascular disease. Atrial fibrillation is a prominent risk marker for underlying cardiovascular disease with a prevalence of 2% in patients < 65 years old. Atrial fibrillation prevalence in NASH is unknown. Read More

View Article
December 2018

Physiological changes after colorectal surgery suggest anastomotic leakage is an early event: a retrospective cohort study.

Colorectal Dis 2018 Dec 11. Epub 2018 Dec 11.

St Mark's Hospital, Watford Road, Harrow, Middlesex, HA1 3UJ.

Introduction: Anastomotic leakage (AL) is often identified 7-10 days after colorectal surgery. However, in retrospect, patients may have abnormalities evident much earlier. This study aims to identify the clinical time-point when AL occurs. Read More

View Article
December 2018

Opioid receptors and opioid peptides in the cardiomyogenesis of mouse embryonic stem cells.

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Free Radical Pathophysiology, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic.

The stimulation of myocardium repair is restricted due to the limited understanding of heart regeneration. Interestingly, endogenous opioid peptides such as dynorphins and enkephalins are suggested to support this process. However, the mechanism-whether through the stimulation of the regenerative capacity of cardiac stem cells or through effects on other cell types in the heart-is still not completely understood. Read More

View Article
December 2018

Cardiac metabolic modulation upon low-carbohydrate low-protein ketogenic diet in diabetic rats studied in vivo using hyperpolarized C pyruvate, butyrate, and acetoacetate probes.

Diabetes Obes Metab 2018 Dec 11. Epub 2018 Dec 11.

Functional Metabolism Group, Singapore Bioimaging Consortium, Agency for Science, Technology, and Research, Singapore.

Aims: To investigate the effects of long-term low-carbohydrate low-protein ketogenic diet (KD) on cardiac metabolism and diabetic cardiomyopathy status in lean diabetic Goto-Kakizaki (GK) rats.

Materials And Methods: Diabetic GK rats were fed with KD for 62 weeks. Cardiac function and metabolism were assessed using magnetic resonance imaging and C magnetic resonance spectroscopy ( C-MRS), at rest and under dobutamine stress. Read More

View Article
December 2018

The lysyl oxidase like 2/3 enzymatic inhibitor, PXS-5153A, reduces crosslinks and ameliorates fibrosis.

J Cell Mol Med 2018 Dec 9. Epub 2018 Dec 9.

Drug Discovery department, Pharmaxis Ltd., Sydney, NSW, Australia.

Fibrosis is characterized by the excessive deposition of extracellular matrix and crosslinked proteins, in particular collagen and elastin, leading to tissue stiffening and disrupted organ function. Lysyl oxidases are key players during this process, as they initiate collagen crosslinking through the oxidation of the ε-amino group of lysine or hydroxylysine on collagen side-chains, which subsequently dimerize to form immature, or trimerize to form mature, collagen crosslinks. The role of LOXL2 in fibrosis and cancer is well documented, however the specific enzymatic function of LOXL2 and LOXL3 during disease is less clear. Read More

View Article
December 2018

Understanding vasovagal syncope akin to the philosopher's stone?

J Cardiovasc Electrophysiol 2018 Dec 11. Epub 2018 Dec 11.

National Heart & Lung Institute, Imperial College, Hammersmith Hospital, London, UK.

Vasovagal syncope (VVS), the most common form of transient loss of consciousness, still awaits a complete understanding of its role in human physiology. This article is protected by copyright. All rights reserved. Read More

View Article
December 2018

Heat acclimation does not affect maximal aerobic power in thermoneutral normoxic or hypoxic conditions.

Exp Physiol 2018 Dec 11. Epub 2018 Dec 11.

Department of Automation, Biocybernetics and Robotics, Jozef Stefan Institute, Ljubljana, Slovenia.

What is the central question of this study? Controlled-hyperthermia heat acclimation protocols induce an array of thermoregulatory and cardiovascular adaptations that facilitate exercise in hot conditions. We investigated whether this ergogenic potential can be transferred to thermoneutral normoxic or hypoxic exercising conditions. What is the main finding and its importance? We show that heat acclimation did not affect maximal cardiac output or maximal aerobic power in thermoneutral normoxic/hypoxic conditions. Read More

View Article
December 2018

Safeguarding older adults with dementia, depression, and delirium in a temporary disaster shelter.

Nurs Forum 2018 Dec 9. Epub 2018 Dec 9.

Center of Innovation in Long-Term Services and Supports, Providence VA Medical Center, Providence, RI.

Natural disasters impact people of every age in the communities where they occur, with older adults being a vulnerable subset of the population. Most disaster shelter volunteer nurses are experienced in addressing common health needs of older adult clients such as diabetes, hypertension, and pulmonary disease. These nurses also have the requisite training to respond to more acute medical events, including the symptoms of a heart attack or stroke. Read More

View Article
December 2018
1 Read

Projected Long-Chain n-3 Fatty Acid Intake Post-Replacement of Vegetables Oils with Stearidonic Acid-Modified Varieties: Results from a National Health and Nutrition Examination Survey 2003-2008 Analysis.

Lipids 2018 Dec 7. Epub 2018 Dec 7.

Department of Nutritional Sciences, The Pennsylvania State University, 110 Chandlee Laboratory, University Park, PA, 16802, USA.

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake is well below the amount recommended by the 2015-2020 Dietary Guidelines for Americans (0.25 g/day), supporting the need for alternative dietary sources. Stearidonic acid (SDA)-enriched soybeans were bioengineered to endogenously synthesize SDA, which can be readily metabolized to EPA in humans; thus, incorporating the derived SDA-enriched soybean oil into the food supply is a potential strategy to increase EPA. Read More

View Article
December 2018
7 Reads

Neurologic recovery after deep hypothermic circulatory arrest in rats: A description of a long-term survival model without blood priming.

Artif Organs 2018 Dec 8. Epub 2018 Dec 8.

Department of Cardiopulmonary Bypass, State key laboratory of Cardiovascular Medicine, Fuwai Hospital, National center for Cardiovascular disease, Chinese Academy of Medical science and Peking Union Medical College, Beijing, China.

Brain injury associated with deep hypothermic circulatory arrest (DHCA) has been recognized in patients with congenital heart diseases and those undergoing aortic arch surgeries. However, the preclinical investigation of long-term cerebral injury and recovery mechanisms related to DHCA has been restricted to a satisfactory recovery animal model with a determined recovery time. This study aimed to evaluate the feasibility of a long-term surviving DHCA model without blood priming in rats, in order to investigate the pathophysiology of long-term complications in further studies. Read More

View Article
December 2018

Combined therapy of infusion of DC from rats with higher expression of IDO and CD40L on rejection post heart transplantation.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7977-7984

Department of Cardiology, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.

Objective: Indoleamine 2, 3-dioxygenase (IDO) can inhibit rejection of graft via inducing T cell apoptosis. CD40L monoclonal antibody (mAb) inhibits T cell activation. However, the effects of the combination of infusion of dendritic cell (DC) from IDO over-expressed donor mice and CD40L mAb on the treatment of graft rejection after heart transplantation have not been reported. Read More

View Article
November 2018
  • Page 1 of 28160