5,628 results match your criteria Heart Rhythm[Journal]


Author's reply to Mediterranean Diet and wine intake could improve atrial function in patients with atrial fibrillation.

Heart Rhythm 2019 Mar 13. Epub 2019 Mar 13.

Heart Centre, Alfred Hospital, Melbourne, Australia; Baker Heart & Diabetes Research Institute, Melbourne, Australia.

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http://dx.doi.org/10.1016/j.hrthm.2019.03.009DOI Listing

Mediterranean Diet and wine intake could improve atrial function in patients with atrial fibrillation.

Heart Rhythm 2019 Mar 13. Epub 2019 Mar 13.

Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia Italy.

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http://dx.doi.org/10.1016/j.hrthm.2019.03.008DOI Listing

Iatrogenic Aortic Regurgitation after Radiofrequency Ablation of Idiopathic Ventricular Arrhythmias Originating from the Aortic Valvular Region.

Heart Rhythm 2019 Mar 13. Epub 2019 Mar 13.

Department of Cardiology, Faculty of Medicine, University of Tsukuba.

Background: Radiofrequency ablation at the aortic root has the potential risk of aortic regurgitation (AR).

Objective: This study investigated the incidence and clinical features of iatrogenic AR after catheter ablation of idiopathic ventricular arrhythmias (VAs) originating from the aortic root.

Methods: We studied 45 consecutive patients with idiopathic VAs originating from the aortic cusps (AC group; n=32) and papillary muscles (control group; n=13) who underwent ablation via a retrograde aortic approach and serial echocardiography before and within 24 hours after the ablation procedure. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.03.010DOI Listing

Mean entropy predicts implantable cardioverter-defibrillator therapy using cardiac magnetic resonance texture analysis of scar heterogeneity.

Heart Rhythm 2019 Mar 5. Epub 2019 Mar 5.

Cardiology Department, Guy's and St Thomas' NHS Foundation Trust, London, UK; School of Biomedical Engineering and Imaging Sciences, King's College London, UK.

Background: Risk stratification of ventricular arrhythmia (VA) remains complex in both ischemic and non-ischemic populations.

Objective: To determine whether scar heterogeneity, quantified by mean entropy, predicts appropriate ICD therapy. We hypothesize that higher mean entropy calculated from cardiac magnetic resonance texture analysis (CMR-TA) will predict appropriate ICD therapy. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.03.001DOI Listing

A regular rhythm showing a change in rate and QRS width in a 41-year-old woman.

Authors:
Hein J Wellens

Heart Rhythm 2019 Mar;16(3):486-488

Cardiovascular Research Institute, Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2018.11.003DOI Listing

HRS 40th anniversary viewpoints: What's it all about?

Authors:
Raymond E Ideker

Heart Rhythm 2019 Mar;16(3):484-485

Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2018.12.010DOI Listing

Left atrial appendage closure with the Watchman device using intracardiac vs transesophageal echocardiography: Procedural and cost considerations.

Heart Rhythm 2019 Mar;16(3):334-342

Division of Cardiac Electrophysiology, Houston Methodist DeBakey Heart and Vascular Center, Houston, Texas. Electronic address:

Background: Imaging guidance for left atrial appendage (LAA) closure (LAAC) conventionally consists of transesophageal echocardiography (TEE) and fluoroscopy under general anesthesia (GA). Intracardiac echocardiography (ICE) can eliminate the need for GA, expedite procedural logistics, and reduce the patient experience to a simple venous puncture.

Objective: The purpose of this study was to define optimal ICE views and compare procedural parameters and cost of ICE vs TEE during LAAC with the Watchman device. Read More

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http://dx.doi.org/10.1016/j.hrthm.2018.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400300PMC

Minimally Invasive Percutaneous Epicardial Placement of a Prototype Miniature Pacemaker with Leadlet under Direct Visualization: A Feasibility Study in an Infant Porcine Model.

Heart Rhythm 2019 Feb 28. Epub 2019 Feb 28.

Division of Cardiology, Children's National Health System. 111 Michigan Ave NW. Washington, DC; Department of Pediatrics, George Washington University School of Medicine. Washington, DC. Electronic address:

Background: Pacemaker implantation in infants is limited to epicardial lead placement and an abdominal generator pocket. We propose a minimally invasive solution using a prototype miniature pacemaker with a steroid-eluting leadlet that can affix against the epicardium under thoracoscopy.

Objectives: To evaluate the safety and feasibility of acute implantation of a prototype miniature pacemaker in an infant porcine model. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.02.033DOI Listing
February 2019
1 Read

Increased risk of late pacemaker implantation after ablation for atrioventricular nodal reentry tachycardia. A 10-year follow up of a nationwide cohort.

Heart Rhythm 2019 Feb 28. Epub 2019 Feb 28.

Heart Centre and Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.

Background: Catheter ablation of the slow pathway is standard treatment for atrioventricular nodal reentry tachycardia (AVNRT), with a well-described, low risk for periprocedural atrioventricular block. Less is known about the risk of pacemaker implantation late after ablation.

Objective: We aimed to quantify the risk of late pacemaker-implantation in a countrywide cohort undergoing first-time ablation for AVNRT. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.02.032DOI Listing
February 2019
1 Read

Interpretation of electrograms is key to understand the clinical potential of ECGI.

Heart Rhythm 2019 Feb 27. Epub 2019 Feb 27.

Department of Cardiology, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.hrthm.2019.02.030DOI Listing
February 2019
1 Read

Author's Reply to "Interpretation of Electrograms is key to Understand the Clinical Potential of Ecgi".

Heart Rhythm 2019 Feb 27. Epub 2019 Feb 27.

Bordeaux University Hospital and IHU LIRYC- Bordeaux, France;Hôpital Cardiologique du Haut Lévèque CHU de Bordeaux Avenue de Magellan 33604 Pessac FRANCE.

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http://dx.doi.org/10.1016/j.hrthm.2019.02.029DOI Listing
February 2019

Why did this patient experience a sudden cardiac arrest? Follow your curiosity!

Heart Rhythm 2019 Feb 25. Epub 2019 Feb 25.

Amsterdam UMC, University of Amsterdam, Heart Center; Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S15475271193015
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http://dx.doi.org/10.1016/j.hrthm.2019.02.028DOI Listing
February 2019
2 Reads

Evolution of Post-Pulmonary Vein Isolation Atrial Fibrillation Inducibility at Redo Ablation: Electrophysiological Evidence of Extra-Pulmonary Vein Substrate Progression.

Heart Rhythm 2019 Feb 25. Epub 2019 Feb 25.

Cardiology Division, Geneva University Hospitals, Geneva, Switzerland.

Background: The electrophysiological substrate underlying atrial fibrillation (AF) progression remains difficult to identify.

Objective: To study the evolution of post-pulmonary vein isolation (PVI) AF inducibility (AFI) after AF ablation, and compare patients with recurrence as organized atrial tachycardia (OATr) vs paroxysmal (pAF) and persistent AF (peAF).

Methods: We studied 99 patients who underwent de novo AF ablation (p1) and redo (p2) for recurrent AF (AFr) or OATr. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.02.026DOI Listing
February 2019

Periodic Repolarization Dynamics as Risk Predictor after Myocardial Infarction: Prospective Validation Study.

Heart Rhythm 2019 Feb 25. Epub 2019 Feb 25.

Medizinische Klinik und Poliklinik I, University Hospital Munich, Ludwig-Maximilians University, Munich, Germany; German Center for Cardiovascular Research (DZHK), partner site: Munich Heart Alliance, Munich, Germany. Electronic address:

Background: Periodic Repolarization Dynamics (PRD) is a novel electrocardiographic phenomenon that refers to sympathetic-activity associated low-frequency modulations of cardiac repolarization. Retrospective post myocardial infarction (MI) studies revealed that increased PRD indicates increased risk for subsequent death.

Objective: This is the first prospective study to validate PRD in post-MI patients receiving up-to-date treatment. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.02.024DOI Listing
February 2019
1 Read

Antiarrhythmic and proarrhythmic effects of subcutaneous nerve stimulation in ambulatory dogs.

Heart Rhythm 2019 Feb 25. Epub 2019 Feb 25.

Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address:

Background: High output subcutaneous nerve stimulation (ScNS) remodels the stellate ganglia and suppresses cardiac arrhythmia.

Objective: To test the hypothesis that long duration low output ScNS causes cardiac nerve sprouting, increases plasma norepinephrine concentration and the durations of paroxysmal atrial tachycardia (PAT) in ambulatory dogs.

Methods: We prospectively randomized 22 dogs (11 males and 11 females) into 5 different output groups for 2 months of ScNS: 0 mA (sham) (N=6), 0. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.02.027DOI Listing
February 2019

Cardiac Sympathectomy For Refractory Ventricular Arrhythmias in Cardiac Sarcoidosis.

Heart Rhythm 2019 Feb 25. Epub 2019 Feb 25.

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine. Electronic address:

Background: Ventricular arrhythmias (VA) in cardiac sarcoidosis (CS) are frequently refractory to both anti-arrhythmic drug therapy (AAD) and catheter ablation (CA). Cardiac sympathetic denervation (CSD) has been shown to reduce VA burden and implantable cardioverter- defibrillator (ICD) shocks in patients with non-ischemic cardiomyopathy.

Objective: We aimed to report our center's preliminary experience with CSD in patients with known or presumed CS and refractory VA. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.02.025DOI Listing
February 2019
1 Read

Erratum.

Authors:

Heart Rhythm 2019 Feb 25. Epub 2019 Feb 25.

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http://dx.doi.org/10.1016/j.hrthm.2019.02.023DOI Listing
February 2019
1 Read

Anchoring in a storm: the importance of substrate in polymorphic ventricular arrhythmias.

Heart Rhythm 2019 Feb 19. Epub 2019 Feb 19.

Cardiac Electrophysiology Program, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2019.02.022DOI Listing
February 2019
1 Read

Feasibility of percutaneous epicardial mapping and ablation for refractory atrial fibrillation: Insights into substrate and lesion transmurality.

Heart Rhythm 2019 Feb 16. Epub 2019 Feb 16.

Center for Arrhythmia Care, Pritzker School of Medicine, The University of Chicago Medicine, Chicago, Illinois; Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China; UCLA Health System, UCLA Cardiac Arrhythmia Center, UCLA David Geffen School of Medicine, Los Angeles, California. Electronic address:

Background: Recurrences of atrial fibrillation (AF) after ablation have been attributed to conduction gaps and nontransmural ablation lesions.

Objective: The purpose of this study was to assess the feasibility of adjunctive percutaneous mapping of the epicardial regions of the left atrium to characterize the transmural extent of substrate and ablation lesions.

Methods: Between 2014 and 2018, combined epicardial and endocardial mapping of AF was performed in 18 patients via an inferior subxiphoid percutaneous approach (16 with previously failed ablation procedures and 2 patients with long-standing persistent AF) at 2 centers. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.02.018DOI Listing
February 2019
1 Read

Erratum.

Authors:

Heart Rhythm 2019 Feb 15. Epub 2019 Feb 15.

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http://dx.doi.org/10.1016/j.hrthm.2019.02.015DOI Listing
February 2019
1 Read

Patient-reported triggers of paroxysmal atrial fibrillation.

Heart Rhythm 2019 Feb 14. Epub 2019 Feb 14.

Division of Cardiology, University of California, San Francisco, San Francisco, California. Electronic address:

Background: Triggers for discrete atrial fibrillation (AF) events remain poorly studied and incompletely characterized.

Objective: The purpose of this study was to describe common triggers for AF and their relationships with patient characteristics.

Methods: We invited symptomatic, paroxysmal AF patients enrolled in the Health eHeart Study and through the patient-centered advocacy organization StopAfib. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.01.027DOI Listing
February 2019
1 Read

Implication of ventricular pacing burden and atrial pacing therapies on the progression of atrial fibrillation: A systematic review and meta-analysis of randomized controlled trials.

Heart Rhythm 2019 Feb 14. Epub 2019 Feb 14.

Centre for Heart Rhythm disorders (CHRD), South Australian Health and Medical Research Institute (SAHMRI), University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia. Electronic address:

Background: Atrial fibrillation (AF) is common after pacemaker implantation. However, the impact of pacemaker algorithms in AF prevention is not well understood.

Objective: The purpose of this study was to evaluate the role of pacing algorithms in preventing AF progression. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.02.020DOI Listing
February 2019
1 Read

Internal insulation breaches in an implantable cardioverter-defibrillator lead with redundant conductors.

Heart Rhythm 2019 Feb 14. Epub 2019 Feb 14.

Minneapolis Heart Institute Foundation, Minneapolis, Minnesota.

Background: Internal insulation breaches (IBR) may result in implantable cardioverter-defibrillator lead failure and adverse clinical events. Concerns exist that the Durata lead may be prone to IBR.

Objective: The goals of this study were to assess Durata failures in the Food and Drug Administration Manufacturer and User Facility Device Experience (MAUDE) database and compare them to failures in MAUDE for Endotak Reliance and Sprint Quattro Secure (QS) leads. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.02.019DOI Listing
February 2019
1 Read

Autoimmune and inflammatory K channelopathies in cardiac arrhythmias: Clinical evidence and molecular mechanisms.

Heart Rhythm 2019 Feb 14. Epub 2019 Feb 14.

Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy. Electronic address:

Cardiac K channelopathies account for a significant proportion of arrhythmias and sudden cardiac death (SCD) in subjects without structural heart disease. It is well recognized that genetic defects are key factors in many cases, and in practice, the term cardiac channelopathies currently coincides with inherited cardiac channelopathies. However, mounting evidence demonstrate that not only genetic alterations but also autoimmune and inflammatory factors can cause cardiac K-channel dysfunction and arrhythmias in the setting of a structurally normal heart. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.02.017DOI Listing
February 2019
1 Read

The 50-year anniversary of the His bundle recording and pacing in clinical medicine.

Heart Rhythm 2019 Feb 13. Epub 2019 Feb 13.

Heart Rhythm Institute and Section of Cardiovascular Diseases, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.

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http://dx.doi.org/10.1016/j.hrthm.2019.02.014DOI Listing
February 2019

Differentiation of fasciculoventricular fibers from anteroseptal accessory pathways using the surface electrocardiogram.

Heart Rhythm 2019 Feb 11. Epub 2019 Feb 11.

Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts. Electronic address:

Background: Fasciculoventricular fibers (FVFs) are responsible for 1%-5% of cases of asymptomatic preexcitation on the surface electrocardiogram (ECG). Unlike ventricular preexcitation seen in Wolff-Parkinson-White (WPW) syndrome, FVFs are not associated with sudden cardiac death from preexcited atrial fibrillation.

Objective: The purpose of this study was to identify surface ECG variables that differentiate FVFs from true WPW syndrome. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.02.011DOI Listing
February 2019
3 Reads

Evidence of relevant electrical connection between the left atrial appendage and the great cardiac vein during catheter ablation of atrial fibrillation.

Heart Rhythm 2019 Feb 11. Epub 2019 Feb 11.

Texas Cardiac Arrhythmia Institute at St. David's Medical Center, Austin, Texas. Electronic address:

Background: Atrial fibrillation (AF) triggers within the coronary sinus (CS)/great cardiac vein (GCV) and the left atrial appendage (LAA) have been recognized as nonpulmonary vein triggers of AF.

Objective: The aim of this study was to describe an electrical connection between the LAA and CS/GCV and its importance in achieving LAA electrical isolation (LAAEI).

Methods: A total of 488 consecutive patients undergoing catheter ablation for persistent or long-standing persistent AF who showed firing from the LAA and/or from the CS/GCV were enrolled in this multicenter prospective study. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.02.009DOI Listing
February 2019
1 Read

Exercise testing oversights underlie missed and delayed diagnosis of catecholaminergic polymorphic ventricular tachycardia in young sudden cardiac arrest survivors.

Heart Rhythm 2019 Feb 11. Epub 2019 Feb 11.

Division of Heart Rhythm Services, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota; Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota; Windland Smith Rice Sudden Death Genomics Laboratory, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota. Electronic address:

Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is characterized by adrenergically induced ventricular tachycardia, syncope, and sudden cardiac arrest (SCA). In the absence of structural disease, exercise-provoked premature ventricular contractions in bigeminy or couplets and nonsustained ventricular tachycardia are highly predictive of CPVT.

Objective: The purpose of this study was to determine the number of missed or delayed CPVT diagnoses attributable to exercise testing oversights in a cohort of young SCA survivors. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.02.012DOI Listing
February 2019
2 Reads

Impact of the arrhythmogenic potential of long lines of conduction slowing at the pulmonary vein area.

Heart Rhythm 2018 Oct 26. Epub 2018 Oct 26.

Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address:

Background: Areas of conduction delay (CD) or conduction block (CB) are associated with higher recurrence rates after ablation therapy for atrial fibrillation (AF).

Objective: Thus far, there are no reports on the quantification of the extensiveness of CD and CB at the pulmonary vein area (PVA) and their clinical relevance.

Methods: Intraoperative high-density epicardial mapping of the PVA (interelectrode distance 2 mm) was performed during sinus rhythm in 268 patients (mean ± SD [minimum-maximum] 67 ± 11 [21-84] years) with and without preoperative AF. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15475271183105
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http://dx.doi.org/10.1016/j.hrthm.2018.10.027DOI Listing
October 2018
4 Reads

Reply to the Editor-Performance and limitations of noninvasive activation mapping.

Heart Rhythm 2019 Feb 7. Epub 2019 Feb 7.

Bordeaux University Hospital, IHU LIRYC, Bordeaux, France; Hôpital Cardiologique du Haut Lévèque, CHU de Bordeaux, Pessac, France.

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http://dx.doi.org/10.1016/j.hrthm.2019.02.003DOI Listing
February 2019
1 Read

The sympathetic nervous system and arrhythmogenic right ventricular cardiomyopathy: Further evidence of a strong tie.

Heart Rhythm 2019 Feb 5. Epub 2019 Feb 5.

Department of Molecular Medicine, Section of Cardiology, University of Pavia, Pavia, Italy; Cardiac Intensive Care Unit, Arrhythmia and Electrophysiology and Experimental Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2019.02.004DOI Listing
February 2019
1 Read

Atrial Ca/calmodulin-dependent protein kinase II: A druggable master switch of atrial fibrillation-associated atrial remodeling?

Authors:
Dobromir Dobrev

Heart Rhythm 2019 Feb 5. Epub 2019 Feb 5.

Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2019.02.002DOI Listing
February 2019
3 Reads

Letter to the Editor-ECG imaging and activation mapping.

Authors:
Yoram Rudy

Heart Rhythm 2019 Feb 5. Epub 2019 Feb 5.

Washington University, St. Louis, Missouri. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2019.02.001DOI Listing
February 2019
3 Reads

Role of the Purkinje system in heritable arrhythmias.

Heart Rhythm 2019 Feb 2. Epub 2019 Feb 2.

Department of Pharmacology, Columbia University Medical Center, New York, New York. Electronic address:

Much has been written about arrhythmias in structurally normal hearts. In this review, we focus on rapid ventricular arrhythmias that occur in hearts having a pathogenic genetic variant that has been found in families in which arrhythmias occur. We discuss these mutations in terms of their effect on cardiac cell electrical function and initiation of arrhythmias. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15475271193010
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http://dx.doi.org/10.1016/j.hrthm.2019.01.034DOI Listing
February 2019
3 Reads

A wide QRS tachycardia followed by alternating bundle branch block.

Authors:
Hein J Wellens

Heart Rhythm 2019 Feb;16(2):323-324

Cardiovascular Research Institute, Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2018.11.007DOI Listing
February 2019

HRS 40th anniversary viewpoints: The journey is more important than the finish.

Authors:
Douglas P Zipes

Heart Rhythm 2019 Feb;16(2):320-322

Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2018.10.019DOI Listing
February 2019

All electrophysiologists have ADD: Is a cure in sight?

Heart Rhythm 2019 Feb;16(2):170-171

Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.

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http://dx.doi.org/10.1016/j.hrthm.2018.12.004DOI Listing
February 2019

Low complication rates using high power (45-50 W) for short duration for atrial fibrillation ablations.

Heart Rhythm 2019 Feb;16(2):165-169

Intermountain Medical Center Heart Institute, Salt Lake City, Utah.

Background: Many centers use radiofrequency (RF) energy at 25-35 W for 30-60 seconds. There is a safety concern about using higher power, especially on the posterior wall.

Objective: The purpose of this study was to examine complication rates for atrial fibrillation (AF) ablations performed with high-power, short-duration RF energy. Read More

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http://dx.doi.org/10.1016/j.hrthm.2018.11.031DOI Listing
February 2019
1 Read

Safety of rapid switching from amiodarone to dofetilide in atrial fibrillation patients with an implantable cardioverter-defibrillator.

Heart Rhythm 2019 Jan 30. Epub 2019 Jan 30.

Kansas City Heart Rhythm Institute & Research Foundation, Overland Park, Kansas. Electronic address:

Background: Dofetilide is a class III antiarrhythmic drug commonly used for treatment of atrial fibrillation. Drug guidelines mandate a 3-month waiting period before initiating dofetilide after amiodarone use. Whether patients with an implantable cardioverter-defibrillator (ICD) can be rapidly switched from amiodarone to dofetilide is not known. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.01.028DOI Listing
January 2019
7 Reads
5.076 Impact Factor

Catheter ablation of polymorphic ventricular tachycardia/fibrillation in patients with and without structural heart disease.

Heart Rhythm 2019 Jan 31. Epub 2019 Jan 31.

Cardiovascular Division, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address:

Background: Catheter ablation for polymorphic ventricular tachycardia and ventricular fibrillation (PMVT/VF) may target triggering premature ventricular contractions (PVCs). Targeting ventricular scar has also been suggested, but data are limited.

Objective: The purpose of this study was to characterize the electrophysiological findings and ablation outcomes for patients with PMVT/VF and structural heart disease (SHD) compared to those with idiopathic VF. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.01.032DOI Listing
January 2019
5 Reads

Increase in CO levels by upregulating late sodium current is proarrhythmic in the heart.

Heart Rhythm 2019 Jan 31. Epub 2019 Jan 31.

Department of Cardiology, Peking University First Hospital, Beijing, China; Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China. Electronic address:

Background: Increased CO levels in the general circulation and/or in the myocardium are common under pathologic conditions.

Objective: The purpose of this study was to test the hypothesis that an increase in CO levels, and not just the subsequent extra- or intracellular acidosis, would augment late sodium current (I) and contribute to arrhythmogenesis in hearts with reduced repolarization reserve.

Methods: Monophasic action potential durations at 90% completion of repolarization (MAPD) from isolated rabbit hearts, I, and extra- (pH) and intracellular pH (pH) values from cardiomyocytes using the whole-cell patch-clamp techniques and 2',7'-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein, acetoxymethyl ester (BCECF-AM), respectively, were measured. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.01.029DOI Listing
January 2019
1 Read

Predicting defibrillator benefit in patients with cardiac resynchronization therapy: A competing risk study.

Heart Rhythm 2019 Jan 31. Epub 2019 Jan 31.

Department of Cardiology, University Hospital, University of Basel, Basel, Switzerland. Electronic address:

Background: Cardiac resynchronization therapy (CRT) reduces morbidity and mortality in selected heart failure patients, but decision-making regarding selection of CRT-defibrillator or CRT-pacemaker is an ongoing debate.

Objective: The purpose of this study was to construct predictive models and scoring systems for implantable cardioverter-defibrillator (ICD) therapy and death without ICD therapy (prior death).

Methods: We pooled 2 prospective cohorts of CRT-D patients with primary prevention indication and used Fine and Gray models to develop independent prognostic models for time to first ICD therapy (event of interest) or death without prior ICD therapy (competing event). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15475271193010
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http://dx.doi.org/10.1016/j.hrthm.2019.01.033DOI Listing
January 2019
7 Reads

Clinical impact of ethanol infusion into the vein of Marshall on the mitral isthmus area evaluated by atrial electrograms recorded inside the coronary sinus.

Heart Rhythm 2019 Jan 30. Epub 2019 Jan 30.

Methodist DeBakey Heart and Vascular Center and Methodist Hospital Research Institute, Houston, Texas.

Background: The left atrial myocardium (LAM) and coronary sinus (CS) musculature (CSM) generate atrial electrograms recorded inside the CS (AECSs). The vein of Marshall (VOM) courses the mitral isthmus (MI), and ethanol infusion into the VOM (EI-VOM) is useful to ablate it. However, its detailed effect on the MI, which contains the LAM, CSM, and those connections, is unknown. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.01.031DOI Listing
January 2019
1 Read

Endoscopic evaluation of the esophagus after catheter ablation of atrial fibrillation using contiguous and optimized radiofrequency applications.

Heart Rhythm 2019 Jan 30. Epub 2019 Jan 30.

Department of Cardiology, Sint-Jan Hospital Bruges, Bruges, Belgium.

Background: The incidence of endoscopically detected esophageal lesions after pulmonary vein isolation (PVI) is as high as 18%. Intraesophageal temperature rise (ITR) during ablation is a predictor of esophageal injury.

Objective: The purpose of this study was to describe an ablation strategy aiming to enclose the pulmonary veins with contiguous, stable, and optimized radiofrequency applications (referred to as CLOSE-PVI). Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.01.030DOI Listing
January 2019
13 Reads

Breast cancer and atrial fibrillation-A malignant combination?

Heart Rhythm 2019 Mar 29;16(3):349-350. Epub 2019 Jan 29.

The Framingham Heart Study, Framingham, Massachusetts; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.hrthm.2018.11.016DOI Listing

Incidence of atrial fibrillation in conjunction with breast cancer.

Heart Rhythm 2019 Mar 29;16(3):343-348. Epub 2019 Jan 29.

Department of Cardiology, University Hospital of Copenhagen, Rigshospitalet, Denmark.

Background: Patients with breast cancer may have an increased incidence of atrial fibrillation (AF) because of the systemic inflammation induced by the cancer and side effects of treatments.

Objective: The purpose of this study was to estimate the long-term incidence of AF in patients with breast cancer compared with the background population.

Methods: We identified patients diagnosed with breast cancer from 1998 to 2015 by using nationwide registries. Read More

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http://dx.doi.org/10.1016/j.hrthm.2018.10.017DOI Listing

Intermittent high impedance from the lead-device compatibility problem.

Heart Rhythm 2019 Jan 30. Epub 2019 Jan 30.

Section of Cardiac Electrophysiology, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1016/j.hrthm.2019.01.026DOI Listing
January 2019

EP match.

Heart Rhythm 2019 Jan 25. Epub 2019 Jan 25.

Vanderbilt Heart and Vascular Institute, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1016/j.hrthm.2019.01.025DOI Listing
January 2019