1,537 results match your criteria Heart Lung and Circulation[Journal]


Upcoding of Clinical Information to Meet Appropriate Use Criteria for Percutaneous Coronary Intervention.

Circ Cardiovasc Qual Outcomes 2019 Mar;12(3):e005025

International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., D.P.F.).

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005025DOI Listing

Regional Variation in RBM20 Causes a Highly Penetrant Arrhythmogenic Cardiomyopathy.

Circ Heart Fail 2019 Mar;12(3):e005371

Division of Cardiovascular Medicine, Department of Medicine (V.N.P., C.C., C.R., M.T.W., E.A.A.), Stanford University School of Medicine, CA.

Background Variants in the cardiomyocyte-specific RNA splicing factor RBM20 have been linked to familial cardiomyopathy, but the causative genetic architecture and clinical consequences of this disease are incompletely defined. Methods and Results To define the genetic architecture of RBM20 cardiomyopathy, we first established a database of RBM20 variants associated with cardiomyopathy and compared these to variants observed in the general population with respect to their location in the RBM20 coding transcript. We identified 2 regions significantly enriched for cardiomyopathy-associated variants in exons 9 and 11. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005371DOI Listing

Case Report of Aggressive Primary Pericardial Mesothelioma Presenting as a Constrictive Pericarditis.

Circ Cardiovasc Imaging 2019 Mar;12(3):e008621

Faculty of Medicine, Laval University, QC (G.M., M.B., M.-E.P., L.C., C.C.).

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http://dx.doi.org/10.1161/CIRCIMAGING.118.008621DOI Listing
March 2019
2 Reads

Cost-Effectiveness of Mitral Valve Repair Versus Replacement for Severe Ischemic Mitral Regurgitation: A Randomized Clinical Trial From the Cardiothoracic Surgical Trials Network

Circ Cardiovasc Qual Outcomes 2018 11 14;11(11):e004466. Epub 2018 Nov 14.

Background: The CTSN (Cardiothoracic Surgical Trials Network) recently reported no difference in left ventricular end-systolic volume index or in survival at 2 years between patients with severe ischemic mitral regurgitation (MR) randomized to mitral valve repair or replacement. However, replacement provided more durable correction of MR and fewer cardiovascular readmissions. Yet, costeffectiveness outcomes have not been addressed. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383805PMC
November 2018
1 Read

Device Programming for His Bundle Pacing.

Circ Arrhythm Electrophysiol 2019 Feb;12(2):e006816

Geisinger Commonwealth School of Medicine, Geisinger heart Institute, Wilkes Barre, PA (P.V.).

Although permanent His bundle pacing was first reported almost 2 decades ago, it is only recently gaining wider adoption, following facilitation of the implant procedure by dedicated tools. An additional challenge is programming the system, as His bundle pacing may have specific configurations and require special considerations which current implantable pulse generators are not designed for. The aim of this article is to provide practical recommendations for programming His bundle pacing, to deliver optimal therapy and ensure patient safety. Read More

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http://dx.doi.org/10.1161/CIRCEP.118.006816DOI Listing
February 2019
3 Reads

Evaluating the Clinical Validity of Hypertrophic Cardiomyopathy Genes.

Circ Genom Precis Med 2019 Feb;12(2):e002460

Department of Pathology, Harvard Medical School/Massachusetts General Hospital, Boston (L.W., B.F.).

Background: Genetic testing for families with hypertrophic cardiomyopathy (HCM) provides a significant opportunity to improve care. Recent trends to increase gene panel sizes often mean variants in genes with questionable association are reported to patients. Classification of HCM genes and variants is critical, as misclassification can lead to genetic misdiagnosis. Read More

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http://dx.doi.org/10.1161/CIRCGEN.119.002460DOI Listing
February 2019

Sex Differences in In-hospital Management and Outcomes of Patients with Acute Coronary Syndrome: Findings from the Improving Care for Cardiovascular Disease in China (CCC) Project.

Circulation 2019 Jan 22. Epub 2019 Jan 22.

Department of Epidemiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, China.

Background: Coronary heart disease (CHD) is a leading cause of mortality among women. Systematic evaluation of the quality of care and outcomes in women hospitalized for acute coronary syndrome (ACS), an acute manifestation of CHD, remains lacking in China.

Methods: The Improving Care for Cardiovascular Disease in China (CCC)-ACS project is an ongoing nationwide registry of the American Heart Association and Chinese Society of Cardiology. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037655DOI Listing
January 2019
3 Reads
14.430 Impact Factor

Novel Biomarkers for the Precisive Diagnosis and Activity Classification of Takayasu Arteritis.

Circ Genom Precis Med 2019 Jan;12(1):e002080

Hypertension Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Diseases, National Center for Cardiovascular Diseases (X.C., F.Q., L.S., B.G., W.Z., L.J., W.W., S.L., H.Z., J.C.), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, P.R. China.

Background: Establishing the diagnosis and determining disease activity of Takayasu arteritis (TA) remains challenging. Novel biomarkers might help to solve this problem.

Methods: In the screening phase, by using large-scale protein arrays detecting samples from 90 subjects (TA active, 29; TA inactive 31; and controls, 30). Read More

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http://dx.doi.org/10.1161/CIRCGEN.117.002080DOI Listing
January 2019
2 Reads

High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice.

Circulation 2019 Mar;139(11):1422-1434

Department of Internal Medicine, Hypertension Section (P.P.-O., H.K.K., W.V.), University of Texas Southwestern Medical Center, Dallas.

Background: Inorganic phosphate (Pi) is used extensively as a preservative and a flavor enhancer in the Western diet. Physical inactivity, a common feature of Western societies, is associated with increased cardiovascular morbidity and mortality. It is unknown whether dietary Pi excess contributes to exercise intolerance and physical inactivity. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411426PMC
March 2019
13 Reads

Hemothelium, Clonal Hematopoiesis of Indeterminate Potential, and Atherosclerosis.

Circulation 2019 Jan;139(1):7-9

Population Sciences Branch of the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (D.L.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314211PMC
January 2019
1 Read

Quantifying Importance of Major Risk Factors for Coronary Heart Disease.

Circulation 2018 Dec 7. Epub 2018 Dec 7.

Cardiology, McGill University Health Centre, Canada.

Background: To optimize preventive strategies for coronary heart disease (CHD), it is essential to understand and appropriately quantify the contribution of its key risk factors. Our objective was to compare the associations of key modifiable CHD risk factors-specifically lipids, systolic blood pressure (SBP), diabetes, and smoking-with incident CHD events based on their prognostic performance, attributable risk fractions, and treatment benefits, overall and by age.

Methods: Pooled participant-level data from four observational cohort studies sponsored by the National Heart, Lung, and Blood Institute were used to create a cohort of 22,626 individuals aged 45-84 years who were initially free of cardiovascular disease. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.031855DOI Listing
December 2018
6 Reads

Endovascular Thrombus Removal for Acute Iliofemoral Deep Vein Thrombosis.

Circulation 2019 Feb;139(9):1162-1173

Mallinckrodt Institute of Radiology, Washington University in St. Louis, MO (S.V.).

Background: The ATTRACT trial (Acute Venous Thrombosis: Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis) previously reported that pharmacomechanical catheter-directed thrombolysis (PCDT) did not prevent postthrombotic syndrome (PTS) in patients with acute proximal deep vein thrombosis. In the current analysis, we examine the effect of PCDT in ATTRACT patients with iliofemoral deep vein thrombosis.

Methods: Within a large multicenter randomized trial, 391 patients with acute deep vein thrombosis involving the iliac or common femoral veins were randomized to PCDT with anticoagulation versus anticoagulation alone (No-PCDT) and were followed for 24 months to compare short-term and long-term outcomes. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389417PMC
February 2019
22 Reads

Hematopoietic Deficiency of the Long Noncoding RNA MALAT1 Promotes Atherosclerosis and Plaque Inflammation.

Circulation 2019 Mar;139(10):1320-1334

Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University, Frankfurt, Germany (S.C., K.M.M., A.F., L.P., N.J., R.A.B., M.M.-R., D.J., S.U., S.D.).

Background: The majority of the human genome comprises noncoding sequences, which are in part transcribed as long noncoding RNAs (lncRNAs). lncRNAs exhibit multiple functions, including the epigenetic control of gene expression. In this study, the effect of the lncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) on atherosclerosis was examined. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.029015DOI Listing
March 2019
1 Read
14.430 Impact Factor

The N-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy.

Circulation 2019 Jan;139(4):533-545

Department of Physiology and Cell Biology (L.E.D., F.A.), Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus.

Background: N-Methyladenosine (m6A) methylation is the most prevalent internal posttranscriptional modification on mammalian mRNA. The role of m6A mRNA methylation in the heart is not known.

Methods: To determine the role of m6A methylation in the heart, we isolated primary cardiomyocytes and performed m6A immunoprecipitation followed by RNA sequencing. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340720PMC
January 2019
34 Reads

Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels.

Circulation 2019 Jan;139(5):620-635

Department of Epidemiology, (A.P.R., B.M.P., N.L.S.), University of Washington, Seattle.

Background: Factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are associated with risk of arterial and venous thrombosis and with hemorrhagic disorders. We aimed to identify and functionally test novel genetic associations regulating plasma FVIII and VWF.

Methods: We meta-analyzed genome-wide association results from 46 354 individuals of European, African, East Asian, and Hispanic ancestry. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.034532DOI Listing
January 2019
13 Reads
14.430 Impact Factor

Dysfunctional and Proinflammatory Regulatory T-Lymphocytes Are Essential for Adverse Cardiac Remodeling in Ischemic Cardiomyopathy.

Circulation 2019 Jan;139(2):206-221

Division of Cardiovascular Disease and Comprehensive Cardiovascular Center, University of Alabama at Birmingham (S.S.B., M.A.I., M.G., G.Z., G.R., T.H., S.D.P.).

Background: Heart failure (HF) is a state of inappropriately sustained inflammation, suggesting the loss of normal immunosuppressive mechanisms. Regulatory T-lymphocytes (Tregs) are considered key suppressors of immune responses; however, their role in HF is unknown. We hypothesized that Tregs are dysfunctional in ischemic cardiomyopathy and HF, and they promote immune activation and left ventricular (LV) remodeling. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322956PMC
January 2019
13 Reads

Evaluation of Macitentan in Patients With Eisenmenger Syndrome.

Circulation 2019 Jan;139(1):51-63

Department of Experimental, Diagnostic and Specialty Medicine-DIMES, University of Bologna, Italy (N.G.).

Background: Eisenmenger syndrome describes congenital heart disease-associated severe pulmonary hypertension accompanied by right-to-left shunting. The multicenter, double-blind, randomized, placebo-controlled, 16-week, phase III MAESTRO study (Macitentan in Eisenmenger Syndrome to Restore Exercise Capacity) evaluated the efficacy and safety of the endothelin receptor antagonist macitentan in patients with Eisenmenger syndrome.

Methods: Patients with Eisenmenger syndrome aged ≥12 years and in World Health Organization functional class II-III were randomized 1:1 to placebo or macitentan 10 mg once daily for 16 weeks. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.033575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314514PMC
January 2019
2 Reads

Hospital Variation in the Utilization and Implementation of Targeted Temperature Management in Out-of-Hospital Cardiac Arrest.

Circ Cardiovasc Qual Outcomes 2018 Nov;11(11):e004829

Department of Emergency Medicine, University of Alabama School of Medicine, Birmingham (M.C.K.).

Background Targeted temperature management (TTM) for out-of-hospital cardiac arrest is associated with improved functional survival and is a class I recommendation in resuscitation guidelines. However, patterns of utilization of TTM and adherence to recommended TTM guidelines in contemporary practice are unknown. Methods and Results In a multicenter, prospective cohort of consecutive adults with non-traumatic out-of-hospital cardiac arrest in the Resuscitation Outcomes Consortium in 2012 to 2015, we identified all adults (≥18 years) who were potential candidates for TTM. Read More

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.004829DOI Listing
November 2018
2 Reads

Ankyrin-B Q1283H Variant Linked to Arrhythmias Via Loss of Local Protein Phosphatase 2A Activity Causes Ryanodine Receptor Hyperphosphorylation.

Circulation 2018 Dec;138(23):2682-2697

Department of Cardiovascular Medicine (W.Z., C.W., J.H., J.Y., J.M., L.G., J.G., H.L., K.H.), Second Affiliated Hospital of Nanchang University, China.

Background: Human loss-of-function variants of ANK2 (ankyrin-B) are linked to arrhythmias and sudden cardiac death. However, their in vivo effects and specific arrhythmogenic pathways have not been fully elucidated.

Methods: We identified new ANK2 variants in 25 unrelated Han Chinese probands with ventricular tachycardia by whole-exome sequencing. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.0
Publisher Site
http://dx.doi.org/10.1161/CIRCULATIONAHA.118.034541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276866PMC
December 2018
7 Reads

Impact of Preexisting Left Bundle Branch Block in Transcatheter Aortic Valve Replacement Recipients.

Circ Cardiovasc Interv 2018 Nov;11(11):e006927

Department of Cardiology, Quebec Heart and Lung Institute, Laval University, Canada (Q.F., E.D., M.C., F.P., J.R.-C.).

Background: The impact of preexisting left bundle branch block (LBBB) in transcatheter aortic valve replacement (TAVR) recipients is unknown. The aim of this study was to determine the impact of preexisting LBBB on clinical outcomes after TAVR.

Methods And Results: This multicenter study evaluated 3404 TAVR candidates according to the presence or absence of LBBB on baseline ECG. Read More

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.006927DOI Listing
November 2018
22 Reads

Transcarotid Compared With Other Alternative Access Routes for Transcatheter Aortic Valve Replacement.

Circ Cardiovasc Interv 2018 Nov;11(11):e006388

Department of Cardiac Surgery and Cardiology, Quebec Heart and Lung Institute, Laval University, Canada (C.C., J.R.-C., E.D., D.D., R.D., J.-M.P., R.P., F.M., T.R.-G., D.K., S.M.).

Background The optimal access for patients undergoing transcatheter aortic valve replacement (TAVR) who are not candidates for a transfemoral approach has not been elucidated. The purpose of this study was to compare the safety, feasibility, and early clinical outcomes of transcarotid TAVR compared with thoracic approaches. Methods and Results From a multicenter consecutive cohort of 329 alternative-access TAVR patients (2012-2017), we identified 101 patients who underwent transcarotid TAVR and 228 patients who underwent a transapical or transaortic TAVR. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.11
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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.006388DOI Listing
November 2018
4 Reads
6.218 Impact Factor

Projected Future Cancer Risks in Children Treated With Fluoroscopy-Guided Cardiac Catheterization Procedures.

Circ Cardiovasc Interv 2018 Nov;11(11):e006765

Ionizing Radiation Epidemiology Laboratory (LEPID) (N.J., E.R., F.D.Z.-B., D.L., M.-O.B., H.B.).

Background Children treated with cardiac catheterization procedures have now a long life expectancy and consequently potential long-term radiation-induced risks. We projected lifetime attributable risks (LARs) of cancer incidence from the most frequent procedures in pediatrics: atrial septal defect closure, patent ductus arteriosus occlusion, or pulmonary valvuloplasty. Methods and Results Organ equivalent doses were estimated for 1251 procedures performed in children aged ≤15 years at 2 reference catheterization centers in France from 2009 to 2013. Read More

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.006765DOI Listing
November 2018
4 Reads

Society of Thoracic Surgeons Risk Score and EuroSCORE-2 Appropriately Assess 30-Day Postoperative Mortality in the STICH Trial and a Contemporary Cohort of Patients With Left Ventricular Dysfunction Undergoing Surgical Revascularization.

Circ Heart Fail 2018 Nov;11(11):e005531

Departments of Medicine, ontreal Heart Institute, University of Montreal, Canada (N.B., J.L.R.).

Background: The STICH trial (Surgical Treatment for Ischemic Heart Failure) demonstrated a survival benefit of coronary artery bypass grafting in patients with ischemic cardiomyopathy and left ventricular dysfunction. The Society of Thoracic Surgeons (STS) risk score and the EuroSCORE-2 (ES2) are used for risk assessment in cardiac surgery, with little information available about their accuracy in patients with left ventricular dysfunction. We assessed the ability of the STS score and ES2 to evaluate 30-day postoperative mortality risk in STICH and a contemporary cohort (CC) of patients with a left ventricle ejection fraction ≤35% undergoing coronary artery bypass grafting outside of a trial setting. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.118
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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309904PMC
November 2018
8 Reads
5.891 Impact Factor

Cardiac Troponin I and Risk of Cardiac Events in Patients With Heart Failure and Preserved Ejection Fraction.

Circ Heart Fail 2018 Nov;11(11):e005312

Cardiovascular Division, Brigham and Women's Hospital, Boston, MA. (P.L.M., B.L.C., I.E.B., E.L., S.D.S., M.A.P., A.S.D.).

Background: Levels of cTn (cardiac troponin) are frequently elevated in patients with heart failure (HF) and reduced ejection fraction (EF) and correlate with the risk for mortality. However, factors associated with high cTn concentrations and the association with cardiovascular events in patients with HF and preserved EF are unclear.

Methods And Results: Of 1767 subjects with symptomatic HF with preserved EF from the Americas part of the TOPCAT trial (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial), 236 underwent baseline measurements of high-sensitivity (hs) cTnI using the Abbott Architect STAT assay. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005312DOI Listing
November 2018
10 Reads
5.891 Impact Factor

Lung Cancer Screening Eligible?

Authors:
Joseph Yeboah

Circulation 2018 Dec;138(25):2867-2868

Heart and Vascular Center of Excellence, Wake Forest University School of Medicine, Winston Salem, NC.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037841DOI Listing
December 2018
1 Read

First In Vivo Use of High-Resolution Near-Infrared Optical Mapping to Assess Atrial Activation During Sinus Rhythm and Atrial Fibrillation in a Large Animal Model.

Circ Arrhythm Electrophysiol 2018 Dec;11(12):e006870

Department of Physiology and Cell Biology (B.J.H., N.L., K.M.H., S.H.A., E.J.A., P.J.M., V.V.F.), The Ohio State University Wexner Medical Center, Columbus.

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http://dx.doi.org/10.1161/CIRCEP.118.006870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300135PMC
December 2018
1 Read

ST2 in Heart Failure.

Circ Heart Fail 2018 Dec;11(12):e005582

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005582DOI Listing
December 2018
2 Reads

Pulmonary Production of Soluble ST2 in Heart Failure.

Circ Heart Fail 2018 Dec;11(12):e005488

IMIB-Arrixaca, University of Murcia, Spain (M.T.P.-M., M.C.A.-L., C.M.M., A.L.).

Background: Serum concentrations of ST2 (interleukin-1 receptor-like 1) represent a meaningful prognostic marker in cardiac diseases. Production of soluble ST2 (sST2) may be partially extracardiac. Identification of sST2 sources is relevant to design strategies for modulating its signaling. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.118
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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005488DOI Listing
December 2018
7 Reads

Evaluating Systolic and Diastolic Cardiac Function in Rodents Using Microscopic Computed Tomography.

Circ Cardiovasc Imaging 2018 Dec;11(12):e007653

German Center for Lung Research (DZL), Justus-Liebig University of Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Giessen, Germany (B.K., J.W., M.K., H.A.G., F.G., N.W., W.S., R.T.S.).

Background: The use of microscopic computed tomography to assess the key functional parameters of systolic emptying or diastolic filling in small animals has not been previously reported. The aim of the study was to test whether microscopic computed tomography can assess the dynamics of both left ventricle and right ventricle (RV) diastolic filling and systolic emptying in an experimental model of pulmonary arterial hypertension Methods and Results: The Wistar-Kyoto rats were injected subcutaneously with the VEGF (vascular endothelial growth factor)-receptor inhibitor SU5416 (20 mg/kg body weight) and were then exposed to chronic hypoxia (10% oxygen) for 21 days (SU5416-hypoxia) followed by normoxia for an additional 2 weeks. Thereafter, multiphase cine cardiac images were acquired using a microscopic computed tomography scanner in conjunction with a blood-pool iodinated contrast agent. Read More

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http://dx.doi.org/10.1161/CIRCIMAGING.118.007653DOI Listing
December 2018
1 Read

Outcomes, Costs, and 30-Day Readmissions After Catheter Ablation of Myocardial Infarct-Associated Ventricular Tachycardia in the Real World.

Circ Arrhythm Electrophysiol 2018 Nov;11(11):e006754

Weill Cornell Cardiovascular Outcomes Research Group (CORG), Division of Cardiology, Department of Medicine, Weill Cornell Medicine-New York Presbyterian Hospital (J.W.C., J.E.I., G.T., C.F.L., S.M.M., B.B.L., L.K.K.).

Background: Patients undergoing catheter ablation of myocardial infarction-associated ventricular tachycardia (VT) have significant comorbidities that can increase the risks of adverse outcomes. The rates of readmissions after VT ablation are unknown. We sought to examine in-hospital outcomes, costs, and 30-day readmissions after catheter ablation of myocardial infarction-associated VT. Read More

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http://dx.doi.org/10.1161/CIRCEP.118.006754DOI Listing
November 2018
5 Reads

Vascular Closure Devices for Transfemoral Angiography.

Circ Cardiovasc Interv 2018 Aug;11(8):e007085

National Heart and Lung Institute, Imperial College London, United Kingdom (R.A., A.N.N.).

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https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.11
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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.007085DOI Listing
August 2018
17 Reads

Benefit and Risk of Prolonged DAPT After Coronary Stenting in Women.

Circ Cardiovasc Interv 2018 Aug;11(8):e005308

Department of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (N.C.B., L.M.).

Background: Women may derive differential benefit from prolonged DAPT (dual antiplatelet therapy) after coronary stenting than men. We assessed whether the risks/benefits of prolonged DAPT differ between women and men.

Methods And Results: The DAPT study was a randomized double-blind, placebo-controlled trial comparing continued thienopyridine versus placebo beyond 12 months after coronary stenting. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.11
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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.117.005308DOI Listing
August 2018
14 Reads

Absence of Myocardial Fibrosis Predicts Favorable Long-Term Survival in New-Onset Heart Failure.

Circ Cardiovasc Imaging 2018 Sep;11(9):e007722

Royal Brompton Hospital, London, United Kingdom (A.G., S.R., B.P.H., N.A.I., K.M., J.K., C.S., P.R.K., J.G.F.C., M.R.C., R.G.A., D.J.P., S.K.P.).

Background: Myocardial fibrosis, identified by late gadolinium enhancement cardiovascular magnetic resonance, predicts outcomes in chronic heart failure (HF). Its prognostic significance in new-onset HF and reduced left ventricular ejection fraction (LVEF) is unclear. We investigated whether the pattern and extent of fibrosis predict survival in new-onset HF and reduced LVEF of initially uncertain pathogenesis. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCIMAGING.118.0077
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http://dx.doi.org/10.1161/CIRCIMAGING.118.007722DOI Listing
September 2018
7 Reads

Astronaut Cardiovascular Health and Risk Modification (Astro-CHARM) Coronary Calcium Atherosclerotic Cardiovascular Disease Risk Calculator.

Circulation 2018 Oct;138(17):1819-1827

Department of Internal Medicine (A.K., J.A.d.L., B.D.L.), at the University of Texas Southwestern Medical Center, Dallas, TX.

Background: Coronary artery calcium (CAC) is a powerful novel risk indicator for atherosclerotic cardiovascular disease (ASCVD). Currently, there is no available ASCVD risk prediction tool that integrates traditional risk factors and CAC.

Methods: To develop a CAC ASCVD risk tool for younger individuals in the general population, subjects aged 40 to 65 without prior cardiovascular disease from 3 population-based cohorts were included. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.033505DOI Listing
October 2018
7 Reads

Long-Term Outcomes After Transcatheter Aortic Valve-in-Valve Replacement.

Circ Cardiovasc Interv 2018 Sep;11(9):e007038

Quebec Heart and Lung Institute, Laval University, Canada (L.d.F.C.G., J.-M.P., E.D., P.P., J.R.-C.).

Background: Data on long-term outcomes after valve-in-valve (ViV) transcatheter aortic valve replacement (TAVR) are scarce. The objective of this study was to determine the long-term clinical outcomes and structural valve degeneration (SVD) over time in patients undergoing ViV-TAVR.

Methods And Results: Consecutive patients undergoing ViV-TAVR in 9 centers between 2009 and 2015 were included. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.11
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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.007038DOI Listing
September 2018
8 Reads

Is Low-Density Lipoprotein Cholesterol the Key to Interpret the Role of Lecithin:Cholesterol Acyltransferase in Atherosclerosis?

Circulation 2018 Sep;138(10):1008-1011

Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (C.V., M.C.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035358DOI Listing
September 2018
26 Reads

Rate, Timing, Correlates, and Outcomes of Hemodynamic Valve Deterioration After Bioprosthetic Surgical Aortic Valve Replacement.

Circulation 2018 Sep;138(10):971-985

Institut Universitaire de Cardiologie et de Pneumologie de Québec/Québec Heart and Lung Institute, Laval University, Canada (E.S., H.M., F.D., P.V., S.M., D.K., R.P., N.C., J.R.-C., P.M., M.-A.C., P.P.).

Background: The incidence of structural valve deterioration after bioprosthesis (BP) aortic valve replacement (AVR) established on the basis of reoperation may substantially underestimate the true incidence. The objective is to determine the rate, timing, correlates, and association between hemodynamic valve deterioration (HVD) and outcomes assessed by Doppler echocardiography after surgical BP AVR.

Methods: A total of 1387 patients (62. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.0
Publisher Site
http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035150DOI Listing
September 2018
10 Reads

Multiple and Mixed Valvular Heart Diseases.

Circ Cardiovasc Imaging 2018 Aug;11(8):e007862

Department of Cardiology, University Hospital of Liege, Sart Tilman University Hospital Center, Belgium (L.P.).

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http://dx.doi.org/10.1161/CIRCIMAGING.118.007862DOI Listing
August 2018
2 Reads

3'-Deoxy-3'-[18F]Fluorothymidine Positron Emission Tomography Depicts Heterogeneous Proliferation Pathology in Idiopathic Pulmonary Arterial Hypertension Patient Lung.

Circ Cardiovasc Imaging 2018 Aug;11(8):e007402

Center for Pharmacology and Therapeutics, Experimental Medicine, Hammersmith Hospital, Imperial College London, United Kingdom (A.A., J.C., O.D., J.W., M.R.W., L.Z.).

Background: Pulmonary vascular cell hyperproliferation is characteristic of pulmonary vascular remodeling in pulmonary arterial hypertension. A noninvasive imaging biomarker is needed to track the pathology and assess the response to novel treatments targeted at resolving the structural changes. Here, we evaluated the application of radioligand 3'-deoxy-3'-[18F]-fluorothymidine (FLT) using positron emission tomography. Read More

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http://dx.doi.org/10.1161/CIRCIMAGING.117.007402DOI Listing
August 2018
3 Reads

Response by Wang et al to Letter Regarding Article, "Magnitude of Soluble ST2 as a Novel Biomarker for Acute Aortic Dissection".

Circulation 2018 Sep;138(12):1281-1282

Beijing Anzhen Hospital, Capital Medical University, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Collaborative Innovation Centre for Cardiovascular Disorders, China (Y.W., J.D.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.0
Publisher Site
http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036720DOI Listing
September 2018
18 Reads

Effect of Everolimus Initiation and Calcineurin Inhibitor Elimination on Cardiac Allograft Vasculopathy in De Novo Heart Transplant Recipients.

Circ Heart Fail 2018 Sep;11(9):e004050

Department of Cardiology, Oslo University Hospital, Rikshospitalet, Norway (S.A., A.K.A., E.G., L.G.).

Background Cardiac allograft vasculopathy (CAV) limits survival after heart transplantation, and the effect of different immunosuppressive regimens on CAV is not fully understood. The randomized SCHEDULE trial (Scandinavian Heart Transplant Everolimus De Novo Study With Early Calcineurin Inhibitors Avoidance) evaluated whether initiation of the proliferation signal inhibitor everolimus and early cyclosporine elimination can reduce CAV development. Methods and Results The SCHEDULE trial was a multicenter Scandinavian trial, where 115 de novo heart transplantation recipients were randomized to everolimus with complete cyclosporine withdrawal 7 to 11 weeks after heart transplantation or standard cyclosporine-based immunosuppression. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004050DOI Listing
September 2018
11 Reads

Outcome of Cardiac Sarcoidosis Presenting With High-Grade Atrioventricular Block.

Circ Arrhythm Electrophysiol 2018 Aug;11(8):e006145

Heart and Lung Center (H.-K.N., J.L., K.E., R.K., P.S., M.K.).

Background: Symptomatic high-grade atrioventricular block (AVB) is the most common and often the only presenting manifestation (lone AVB) of cardiac sarcoidosis. Implantation of an intracardiac cardioverter defibrillator instead of a pacemaker is recommended, but the true risk of fatal arrhythmia, one incident to lone AVB in particular, remains poorly known.

Methods: We used Myocardial Inflammatory Diseases in Finland Study Group Registry to analyze the presentations, left ventricular (LV) function, pacemaker therapy, and ventricular arrhythmias in cardiac sarcoidosis. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCEP.117.006145
Publisher Site
http://dx.doi.org/10.1161/CIRCEP.117.006145DOI Listing
August 2018
15 Reads

Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension.

Circ Genom Precis Med 2018 Oct;11(10):e002087

Department of Pediatrics, College of Physicians and Surgeons (L.M., N.Z., U.K., E.B.R., W.K.C.), Columbia University, New York, NY.

Background: In pulmonary arterial hypertension (PAH), pathological changes in pulmonary arterioles progressively raise pulmonary artery pressure and increase pulmonary vascular resistance, leading to right heart failure and high mortality rates. Recently, the first potassium channelopathy in PAH, because of mutations in KCNK3, was identified as a genetic cause and pharmacological target.

Methods: Exome sequencing was performed to identify novel genes in a cohort of 99 pediatric and 134 adult-onset group I PAH patients. Read More

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http://dx.doi.org/10.1161/CIRCGEN.118.002087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206877PMC
October 2018
49 Reads

Genotype and Lifetime Burden of Disease in Hypertrophic Cardiomyopathy: Insights from the Sarcomeric Human Cardiomyopathy Registry (SHaRe).

Circulation 2018 Oct 23;138(14):1387-1398. Epub 2018 Aug 23.

Cardiomyopathy Unit and Genetic Unit, Careggi University Hospital, Florence, Italy.

Background: A better understanding of the factors that contribute to heterogeneous outcomes and lifetime disease burden in hypertrophic cardiomyopathy (HCM) is critically needed to improve patient management and outcomes. The Sarcomeric Human Cardiomyopathy Registry (SHaRe) was established to provide the scale of data required to address these issues, aggregating longitudinal datasets curated by eight international HCM specialty centers.

Methods: Data on 4591 HCM patients (2763 genotyped), followed for a mean of 5. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.0
Publisher Site
http://dx.doi.org/10.1161/CIRCULATIONAHA.117.033200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170149PMC
October 2018
5 Reads

Early Regenerative Capacity in the Porcine Heart.

Circulation 2018 Dec;138(24):2798-2808

National Heart Research Institute Singapore, National Heart Centre Singapore (L.Y., S.J.L., C.X.W., L.P.S., S.H.T., G.Z.T., C.J.P., R.S.T., S.A.C.).

Background: The adult mammalian heart has limited ability to repair itself after injury. Zebrafish, newts, and neonatal mice can regenerate cardiac tissue, largely by cardiac myocyte (CM) proliferation. It is unknown whether hearts of young large mammals can regenerate. Read More

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http://circ.ahajournals.org/lookup/doi/10.1161/CIRCULATIONAH
Publisher Site
http://dx.doi.org/10.1161/CIRCULATIONAHA.117.031542DOI Listing
December 2018
42 Reads

Preoperative Predictors of Death and Sustained Ventricular Tachycardia After Pulmonary Valve Replacement in Patients With Repaired Tetralogy of Fallot Enrolled in the INDICATOR Cohort.

Circulation 2018 Nov;138(19):2106-2115

Department of Cardiology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, MA (T.G., K.G., K.H., A.J.P., A.M.V.).

Background: Risk factors for adverse clinical outcomes have been identified in patients with repaired tetralogy of Fallot before pulmonary valve replacement (PVR). However, pre-PVR predictors for post-PVR sustained ventricular tachycardia and death have not been identified.

Methods: Patients with repaired tetralogy of Fallot enrolled in the INDICATOR cohort (International Multicenter TOF Registry), a 4-center international cohort study, who had a comprehensive preoperative evaluation and subsequently underwent PVR were included. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.034740DOI Listing
November 2018
4 Reads

Multigenic Disease and Bilineal Inheritance in Dilated Cardiomyopathy Is Illustrated in Nonsegregating LMNA Pedigrees.

Circ Genom Precis Med 2018 Jul;11(7):e002038

Dorothy M. Davis Heart and Lung Research Institute (J.R.C., D.D.K., A.M., L.S., R.E.H.)

Background: We have previously described 19 pedigrees with apparent lamin ()-related dilated cardiomyopathy (DCM) manifesting in affected family members across multiple generations. In 6 of 19 families, at least 1 individual with idiopathic DCM did not carry the family's variant. We hypothesized that additional genetic cause may underlie DCM in these families. Read More

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http://dx.doi.org/10.1161/CIRCGEN.117.002038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294440PMC
July 2018
20 Reads

Response by Brida et al to Letter Regarding Article, "Systemic Right Ventricle in Adults With Congenital Heart Disease: Anatomic and Phenotypic Spectrum and Current Approach to Management".

Circulation 2018 Jul;138(3):326-327

Adult Congenital Heart Centre, National Centre for Pulmonary Hypertension, Royal Brompton Hospital, London, UK (M.B., G.-P.D., M.A.G.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.0
Publisher Site
http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035222DOI Listing
July 2018
11 Reads