985 results match your criteria Heart Failure Reviews[Journal]


Personalized physiology-guided resuscitation in highly monitored patients with cardiac arrest-the PERSEUS resuscitation protocol.

Heart Fail Rev 2019 Feb 11. Epub 2019 Feb 11.

School of Medicine, European University Cyprus, Nicosia, Cyprus.

Resuscitation guidelines remain uniform across all cardiac arrest patients, focusing on the delivery of chest compressions to a standardized rate and depth and algorithmic vasopressor dosing. However, individualizing resuscitation to the appropriate hemodynamic and ventilatory goals rather than a standard "one-size-fits-all" treatment seems a promising new therapeutic strategy. In this article, we present a new physiology-guided treatment strategy to titrate the resuscitation efforts to patient's physiologic response after cardiac arrest. Read More

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http://dx.doi.org/10.1007/s10741-019-09772-7DOI Listing
February 2019
1 Read

The relevance of microRNA in post-infarction left ventricular remodelling and heart failure.

Heart Fail Rev 2019 Feb 2. Epub 2019 Feb 2.

Department of Biochemistry and Molecular Biology, University of Bielsko-Biala, Faculty of Health Sciences, Willowa St. 2, 43-309, Bielsko-Biała, Poland.

Myocardial infarction and post-infarction left ventricular remodelling involve a high risk of morbidity and mortality. For this reason, ongoing research is being conducted in order to learn the mechanisms of unfavourable left ventricular remodelling following a myocardial infarction. New biomarkers are also being sought that would allow for early identification of patients with a high risk of post-infarction remodelling and dysfunction of the left ventricle. Read More

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http://dx.doi.org/10.1007/s10741-019-09770-9DOI Listing
February 2019

Curcumin as a potential modulator of M1 and M2 macrophages: new insights in atherosclerosis therapy.

Heart Fail Rev 2019 Jan 23. Epub 2019 Jan 23.

Werlhof-Institut, Hannover, Germany.

Accumulation of macrophages within the artery wall is an eminent feature of atherosclerotic plaques. Macrophages are influenced by various plaque microenvironmental stimuli, such as oxidized lipids, cytokines, and senescent erythrocytes, and thereby polarize into two main phenotypes called proinflammatory M1 and anti-inflammatory M2 macrophages. In the hemorrhagic zones of atheroma, upon exposure to iron, sequestration of iron by M1 macrophages results in an uncontrolled proinflammatory phenotype impairing wound healing, while M2 macrophages phagocytose both apoptotic cells and senescent erythrocytes. Read More

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http://dx.doi.org/10.1007/s10741-018-09764-zDOI Listing
January 2019
1 Read

Experimental models of cardiac physiology and pathology.

Heart Fail Rev 2019 Jan 22. Epub 2019 Jan 22.

Icahn School of Medicine at Mount Sinai, New York, USA.

Experimental models of cardiac disease play a key role in understanding the pathophysiology of the disease and developing new therapies. The features of the experimental models should reflect the clinical phenotype, which can have a wide spectrum of underlying mechanisms. We review characteristics of commonly used experimental models of cardiac physiology and pathophysiology in all translational steps including in vitro, small animal, and large animal models. Read More

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http://dx.doi.org/10.1007/s10741-019-09769-2DOI Listing
January 2019
1 Read

Pharmacogenomics of amlodipine and hydrochlorothiazide therapy and the quest for improved control of hypertension: a mini review.

Heart Fail Rev 2019 Jan 15. Epub 2019 Jan 15.

Department of Haematology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, 7505, South Africa.

Blood pressure (BP) is a complex trait that is regulated by multiple physiological pathways and include but is not limited to extracellular fluid volume homeostasis, cardiac contractility, and vascular tone through renal, neural, or endocrine systems. Uncontrolled hypertension (HTN) has been associated with an increased mortality risk. Therefore, understanding the genetics that underpins and influence BP regulation will have a major impact on public health. Read More

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http://dx.doi.org/10.1007/s10741-018-09765-yDOI Listing
January 2019
1 Read

Effect of mineralocorticoid receptor antagonists on cardiac function in patients with heart failure and preserved ejection fraction: a systematic review and meta-analysis of randomized controlled trials.

Heart Fail Rev 2019 Jan 7. Epub 2019 Jan 7.

Department of Health Policy, The London School of Economics and Political Science, London, UK.

Heart failure with preserved ejection fraction (HFpEF) is a disease with limited evidence-based treatment options. Mineralocorticoid receptor antagonists (MRA) offer benefit in heart failure with reduced ejection fraction (HFrEF), but their impact in HFpEF remains unclear. We therefore evaluated the effect of MRA on echocardiographic, functional, and systemic parameters in patients with HFpEF by a systematic review and meta-analysis. Read More

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http://link.springer.com/10.1007/s10741-018-9758-0
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http://dx.doi.org/10.1007/s10741-018-9758-0DOI Listing
January 2019
16 Reads

Review on sudden death risk reduction after septal reduction therapies in hypertrophic obstructive cardiomyopathy.

Heart Fail Rev 2019 Jan 8. Epub 2019 Jan 8.

Mid-German Heart Center, Department of Internal Medicine III, Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06120, Halle (Saale), Germany.

Treatment of left ventricular outflow tract (LVOT) obstruction in hypertrophic obstructive cardiomyopathy (HOCM) with septal reduction, either with myectomy or alcohol septal ablation, is aiming to reduce the LVOT gradient and improve symptoms in patients who are refractory to or do not tolerate medical treatment. Apart from contributing to the evolution to heart failure, LVOT obstruction is considered a risk factor for sudden cardiac death (SCD). Both septal reduction treatments have been proven effective in reducing symptoms and seem to improve survival, which has been shown equal to the expected in the normal population. Read More

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http://link.springer.com/10.1007/s10741-018-09767-w
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http://dx.doi.org/10.1007/s10741-018-09767-wDOI Listing
January 2019
7 Reads

Subcutaneous furosemide for the treatment of heart failure: a state-of-the art review.

Heart Fail Rev 2019 Jan 8. Epub 2019 Jan 8.

Division of Cardiovascular Medicine, St. Elizabeth's Medical Center/ Tufts University School of Medicine, Brighton, MA, 02135, USA.

The prevalence of heart failure (HF) is on the rise. By 2030, over eight million Americans (46% increase from current prevalence) will have heart failure. In the USA, approximately 30 billion dollars is spent annually on heart failure and this number will likely double in 2030. Read More

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http://dx.doi.org/10.1007/s10741-018-9760-6DOI Listing
January 2019

Left ventricular noncompaction, morphological, and clinical features for an integrated diagnosis.

Heart Fail Rev 2019 Jan 5. Epub 2019 Jan 5.

Cardiovascular Department, Cardiomyopathy Center, Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy.

The presence of myocardial noncompaction (NC), regardless of the criterion used, does not identify cardiomyopathy per se. The distinction between a morphological variant and the presence of an NC cardiomyopathy is challenging. However, thanks to larger cohorts of patients and longer periods of follow-up, better clinical characterization and prognostic evaluation are becoming available. Read More

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http://dx.doi.org/10.1007/s10741-018-9763-3DOI Listing
January 2019

Current animal models for the study of congestion in heart failure: an overview.

Heart Fail Rev 2019 Jan 5. Epub 2019 Jan 5.

BIOMED - Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium.

Congestion (i.e., backward failure) is an important culprit mechanism driving disease progression in heart failure. Read More

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http://link.springer.com/10.1007/s10741-018-9762-4
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http://dx.doi.org/10.1007/s10741-018-9762-4DOI Listing
January 2019
2 Reads

Obesity and heart failure with preserved ejection fraction: a paradox or something else?

Heart Fail Rev 2019 Jan 5. Epub 2019 Jan 5.

Clinical Research Unit, University of Milan-Bicocca and Istituto Auxologico Italiano, Viale della Resistenza 23, 20036, Meda, Italy.

Obesity represents one of the most common comorbidities in patients with heart failure and preserved ejection fraction (HFpEF). Studies have shown that obesity is not only a comorbidity, but it could also be an important risk factor for HFpEF development. The mechanisms that connect obesity and HFpEF vary from obesity-induced hemodynamic changes to important biohumoral systems such as adipocitokines, renin-angiotensin-aldosterone and sympathetic nervous systems, natriuretic peptide, and oxidative stress. Read More

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http://dx.doi.org/10.1007/s10741-018-09766-xDOI Listing
January 2019

Comparison of survival for cardiac resynchronization therapy in atrial fibrillation patients with or without atrio-ventricular junction ablation and patients in sinus rhythm: a systematic review and network meta-analysis.

Heart Fail Rev 2019 Jan 4. Epub 2019 Jan 4.

Department of Cardiology, the Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Xueyuanxi Road, No. 109, Wenzhou, 325000, Zhejiang, China.

Cardiac resynchronization therapy (CRT) has been established to improve prognosis for patients with heart failure and SR. Whether the benefit observed with CRT on survival was similar in AF patients receiving atrio-ventricular junction ablation (AVJA) or not and patients in SR remains uncertain. The primary purpose of this study was to comprehensively evaluate the impact of CRT on the outcome of survival in atrial fibrillation (AF) patients with or without AVJA and patients in sinus rhythm (SR). Read More

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http://dx.doi.org/10.1007/s10741-018-9761-5DOI Listing
January 2019
1 Read

Practical guidance on the use of sacubitril/valsartan for heart failure.

Heart Fail Rev 2018 Dec 18. Epub 2018 Dec 18.

Department of Medicine, Division of Cardiology, Washington University in St Louis, St Louis, MO, USA.

Sacubitril/valsartan is a first-in-class angiotensin receptor-neprilysin inhibitor (ARNI) that has been recommended in clinical practice guidelines to reduce morbidity and mortality in patients with chronic, symptomatic heart failure (HF) with reduced ejection fraction (HFrEF). This review provides an overview of ARNI therapy, proposes strategies to improve the implementation of sacubitril/valsartan in clinical practice, and provides clinicians with evidence-based, practical guidance on the use of sacubitril/valsartan in patients with HFrEF. Despite evidence demonstrating the benefits of ARNI therapy over standard of care, only a fraction of eligible patients takes sacubitril/valsartan. Read More

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http://dx.doi.org/10.1007/s10741-018-9757-1DOI Listing
December 2018
1 Read

Protective role of beta-blockers in chemotherapy-induced cardiotoxicity-a systematic review and meta-analysis of carvedilol.

Heart Fail Rev 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.

Some randomized controlled trials (RCTs) have tested the efficacy of beta-blockers as prophylactic agents on cancer therapy-induced cardiotoxicity; however, the quality of this evidence remains undetermined. This systematic review and meta-analysis study aims to evaluate the prophylactic effects of beta-blockers, especially carvedilol, on chemotherapy-induced cardiotoxicity. RCTs were identified by searching the MEDLINE (PubMed), Embase (OvidSP), Cochrane CENTRAL (OvidSP), etc. Read More

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http://dx.doi.org/10.1007/s10741-018-9755-3DOI Listing
December 2018
3.787 Impact Factor

Wnt/β-catenin in ischemic myocardium: interactions and signaling pathways as a therapeutic target.

Heart Fail Rev 2018 Dec 12. Epub 2018 Dec 12.

Department of biochemistry and hematology, faculty of medicine, Semnan University of Medical Sciences, Semnan, Iran.

Cardiovascular disease (CVD) is still a factor of mortality in the whole world. Through canonical and noncanonical pathways and with different receptors, the Wnt/β-catenin signaling pathway plays an essential role in response to heart injuries. Wnt regulates the mobilization and proliferation of cells in endothelium and epicardium in an infarcted heart. Read More

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http://dx.doi.org/10.1007/s10741-018-9759-zDOI Listing
December 2018

Improvement of hyponatremia is associated with lower mortality risk in patients with acute decompensated heart failure: a meta-analysis of cohort studies.

Heart Fail Rev 2018 Dec 10. Epub 2018 Dec 10.

Department of Interventional Medicine, Weihai Municipal Hospital, Weihai, 264200, China.

Hyponatremia at admission is predictive of poor prognosis in patients with acute decompensated heart failure (ADHF). We performed a meta-analysis of cohort studies to evaluate whether improvement of hyponatremia is associated with improved survival in patients with ADHF and hyponatremia. Relevant studies were identified through systematic search of PubMed and Embase. Read More

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http://dx.doi.org/10.1007/s10741-018-9753-5DOI Listing
December 2018
2 Reads

Mitochondrial membrane transporters and metabolic switch in heart failure.

Heart Fail Rev 2018 Dec 10. Epub 2018 Dec 10.

Cardiovascular Diseases and Diabetes Biology group, Rajiv Gandhi Centre for Biotechnology (RGCB), Poojappura, Thycaud Post, Trivandrum, Kerala, 695014, India.

Mitochondrial dysfunction is widely recognized as a major factor for the progression of cardiac failure. Mitochondrial uptake of metabolic substrates and their utilization for ATP synthesis, electron transport chain activity, reactive oxygen species levels, ion homeostasis, mitochondrial biogenesis, and dynamics as well as levels of reactive oxygen species in the mitochondria are key factors which regulate mitochondrial function in the normal heart. Alterations in these functions contribute to adverse outcomes in heart failure. Read More

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http://link.springer.com/10.1007/s10741-018-9756-2
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http://dx.doi.org/10.1007/s10741-018-9756-2DOI Listing
December 2018
4 Reads

Updates in heart failure 30-day readmission prevention.

Heart Fail Rev 2018 Nov 28. Epub 2018 Nov 28.

University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, 06032, USA.

Heart failure (HF) and HF 30-day readmission rates have been a major focus of efforts to reduce health care cost in the recent era. Since the implementation of the Affordable Care Act (ACA) in 2012 and the Hospital Readmission Reduction Program (HRRP), concerted efforts have focused on reduction of 30-day HF readmissions and other admission diagnoses targeted by the HRRP. Hospitals and organizations have instituted wide-ranging programs to reduce short-term readmissions, but the data supporting these programs is often mixed. Read More

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http://dx.doi.org/10.1007/s10741-018-9754-4DOI Listing
November 2018

Atrial fibrillation in hypertrophic cardiomyopathy: prevalence, clinical impact, and management.

Heart Fail Rev 2018 Nov 19. Epub 2018 Nov 19.

Division of Cardiology, Lehigh Valley Health Network, 1200 S. Cedar Crest Blvd, Allentown, PA, 18103, USA.

Hypertrophic cardiomyopathy (HCM) is the most common hereditary cardiomyopathy characterized by left ventricular hypertrophy and spectrum of clinical manifestation. Atrial fibrillation (AF) is a common sustained arrhythmia in HCM patients and is primarily related to left atrial dilatation and remodeling. There are several clinical, electrocardiographic (ECG), and echocardiographic (ECHO) features that have been associated with development of AF in HCM patients; strongest predictors are left atrial size, age, and heart failure class. Read More

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http://link.springer.com/10.1007/s10741-018-9752-6
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http://dx.doi.org/10.1007/s10741-018-9752-6DOI Listing
November 2018
20 Reads
3.790 Impact Factor

Cell-based therapies for the treatment of myocardial infarction: lessons from cardiac regeneration and repair mechanisms in non-human vertebrates.

Heart Fail Rev 2019 Jan;24(1):133-142

Department of Animal Biology, Faculty of Sciences, University of Málaga, Instituto Malagueño de Biomedicina (IBIMA), Campus de Teatinos s/n, 29071, Málaga, Spain.

Ischemic cardiomyopathy is the cardiovascular condition with the highest impact on the Western population. In mammals (humans included), prolonged ischemia in the ventricular walls causes the death of cardiomyocytes (myocardial infarction, MI). The loss of myocardial mass is soon compensated by the formation of a reparative, non-contractile fibrotic scar that ultimately affects heart performance. Read More

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http://link.springer.com/10.1007/s10741-018-9750-8
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http://dx.doi.org/10.1007/s10741-018-9750-8DOI Listing
January 2019
8 Reads

The use of hospital-based services by heart failure patients in the last year of life: a discussion paper.

Heart Fail Rev 2018 Nov 3. Epub 2018 Nov 3.

School of Nursing and Midwifery, Western Sydney University, Locked Bag 1797, Penrith, NSW, 2751, Australia.

Individuals with chronic heart failure have high utilisation of hospital-related services towards the end of life and receive treatments that provide symptom relief without improving life expectancy. The aim of this discussion paper is to determine chronic heart failure patients' use of acute hospital-based services in their last year of life and to discuss the potential for palliative care to reduce service utilisation. A systematic search of the literature was conducted. Read More

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http://link.springer.com/10.1007/s10741-018-9751-7
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http://dx.doi.org/10.1007/s10741-018-9751-7DOI Listing
November 2018
6 Reads

The effect of influenza vaccination on mortality and hospitalization in patients with heart failure: a systematic review and meta-analysis.

Heart Fail Rev 2019 Jan;24(1):109-114

Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Influenza infection is associated with increased risk for mortality and hospitalization in heart failure patients. Although there are no published randomized controlled trials examining the effect of influenza vaccination on clinical outcomes in heart failure patients, the effect has been examined in observational cohort studies. Nevertheless, results are inconsistent due partly to limited power with small sample sizes and use of different definitions of outcomes. Read More

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http://link.springer.com/10.1007/s10741-018-9736-6
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http://dx.doi.org/10.1007/s10741-018-9736-6DOI Listing
January 2019
23 Reads
3.790 Impact Factor

Diabetic cardiomyopathy: molecular mechanisms, detrimental effects of conventional treatment, and beneficial effects of natural therapy.

Heart Fail Rev 2018 Oct 22. Epub 2018 Oct 22.

Center for Biological Sciences, Department of Biochemistry, K.S. Rangasamy College of Arts and Science (Autonomous), Tiruchengode, Tamil Nadu, 637215, India.

Abstarct: Diabetic complications are among the largely exigent health problems currently. Cardiovascular complications, including diabetic cardiomyopathy (DCM), account for more than 80% of diabetic deaths. Investigators are exploring new therapeutic targets to slow or abate diabetes because of the growing occurrence and augmented risk of deaths due to its complications. Read More

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http://dx.doi.org/10.1007/s10741-018-9749-1DOI Listing
October 2018
1 Read
3.787 Impact Factor

Takotsubo syndrome: a neurocardiac syndrome inside the autonomic nervous system.

Heart Fail Rev 2018 Oct 20. Epub 2018 Oct 20.

Cardiovascular and Thoracic Department, University Hospital of Verona, P. Stefani 1, 37126, Verona, Italy.

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http://dx.doi.org/10.1007/s10741-018-9748-2DOI Listing
October 2018

Chronic heart failure: a disease of the brain.

Heart Fail Rev 2018 Oct 20. Epub 2018 Oct 20.

Halberg Chronobiology Center, University of Minnesota Medical School, Minneapolis, USA.

The underlying mechanism for clinical and biochemical manifestations of chronic heart failure (HF) may be due in part to neurohumoral adaptations, such as activation of the renin-angiotensin-aldosterone and sympathetic nervous systems in the periphery and the brain. Internet search and discussion with colleagues are the methods for this study. Since chronic HF is associated with autonomic imbalance with increased sympathetic nerve activity and a withdrawal of parasympathetic activity, it may be considered a brain disease. Read More

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http://link.springer.com/10.1007/s10741-018-9747-3
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http://dx.doi.org/10.1007/s10741-018-9747-3DOI Listing
October 2018
7 Reads

Autonomic regulation device therapy in heart failure with reduced ejection fraction: a systematic review and meta-analysis of randomized controlled trials.

Heart Fail Rev 2018 Oct 13. Epub 2018 Oct 13.

Cardiology Department, Benha Faculty of Medicine, Benha University, Benha, 13518, Egypt.

Heart failure with reduced ejection fraction (HFrEF) represents a significant public health burden associated with incremental health care costs. Given the limitations associated with pharmacological autonomic regulation therapy (ART), device-based autonomic neuromodulation is on the horizon now for ART in those patients. This systematic review aimed primarily to determine the effect of ART by devices on functional status and quality of life (QOL) in patients with HFrEF. Read More

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http://link.springer.com/10.1007/s10741-018-9745-5
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http://dx.doi.org/10.1007/s10741-018-9745-5DOI Listing
October 2018
5 Reads
3.790 Impact Factor

Left ventricular assist device recovery: does duration of mechanical support matter?

Heart Fail Rev 2018 Oct 9. Epub 2018 Oct 9.

University of Miami, Miller School of Medicine, Miami, FL, USA.

Heart failure is a widespread condition in the United States that is predicted to significantly increase in prevalence in the next decade. Many heart failure patients are given a left ventricular assist device (LVAD) while they wait for a heart transplant, while those that are not able to undergo a heart transplant may be given an LVAD permanently. However, past studies have observed a small subset of heart failure patients that recovered cardiac function of their native heart after being placed on an LVAD. Read More

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http://dx.doi.org/10.1007/s10741-018-9744-6DOI Listing
October 2018

Intercalated discs: cellular adhesion and signaling in heart health and diseases.

Heart Fail Rev 2019 Jan;24(1):115-132

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.

Intercalated discs (ICDs) are highly orchestrated structures that connect neighboring cardiomyocytes in the heart. Three major complexes are distinguished in ICD: desmosome, adherens junction (AJ), and gap junction (GJ). Desmosomes are major cell adhesion junctions that anchor cell membrane to the intermediate filament network; AJs connect the actin cytoskeleton of adjacent cells; and gap junctions metabolically and electrically connect the cytoplasm of adjacent cardiomyocytes. Read More

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http://link.springer.com/10.1007/s10741-018-9743-7
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http://dx.doi.org/10.1007/s10741-018-9743-7DOI Listing
January 2019
4 Reads

Implantable devices to monitor patients with heart failure.

Heart Fail Rev 2018 Nov;23(6):849-857

Attikon General University Hospital, 1 Rimini Str, 122 43, Chaidari, Greece.

Reducing heart failure hospitalizations represents a major challenge for modern clinicians. Early detection of congestion plays a key role in disease management strategy. Apart from traditional methods (patient reporting symptoms, body weight monitoring), novel home-care strategies allow guided adjustments in medical therapy through telemonitoring embedded in cardiac electronic implantable devices or through stand-alone diagnostic devices for hemodynamic monitoring. Read More

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http://link.springer.com/10.1007/s10741-018-9742-8
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http://dx.doi.org/10.1007/s10741-018-9742-8DOI Listing
November 2018
13 Reads

Structural and functional abnormalities in iron-depleted heart.

Heart Fail Rev 2018 Oct 3. Epub 2018 Oct 3.

Laboratory for the Applied Research on Cardiovascular System, Department of Heart Diseases, Wroclaw Medical University, Wrocław, Poland.

Iron deficiency (ID) is a common and ominous comorbidity in heart failure (HF) and predicts worse outcomes, independently of the presence of anaemia. Accumulated data from animal models of systemic ID suggest that ID is associated with several functional and structural abnormalities of the heart. However, the exact role of myocardial iron deficiency irrespective of systemic ID and/or anaemia has been elusive. Read More

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http://link.springer.com/10.1007/s10741-018-9738-4
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http://dx.doi.org/10.1007/s10741-018-9738-4DOI Listing
October 2018
1 Read

Creation of a restrictive atrial left-to-right shunt: a novel treatment for heart failure.

Authors:
R De Rosa D Schranz

Heart Fail Rev 2018 Nov;23(6):841-847

Hessen Pediatric Heart Center Giessen & Frankfurt, Goethe University Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany.

Elevated left atrial (LA) filling pressures are associated with poor prognosis in patients with heart failure (HF). Recent evidences have shown that, in this setting, the presence of restrictive small atrial defect may protect from an extreme increase in LA pressure and prevent consecutive pulmonary congestion and acute decompensation, without the expense of an unfavourable significant left-to-right shunt. Therefore, decompression of LA by creating a unidirectional but restrictive left-to-right interatrial shunt has been emerging as a new therapeutic strategy in patients suffering from both HF with preserved and reduced ejection fraction. Read More

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http://dx.doi.org/10.1007/s10741-018-9741-9DOI Listing
November 2018
11 Reads

Cardiac resynchronization therapy and outcomes in patients with left ventricular assist devices: a systematic review and meta-analysis.

Heart Fail Rev 2018 Sep 27. Epub 2018 Sep 27.

Division of Cardiovascular Diseases, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

The impact of cardiac resynchronization therapy (CRT) on clinical outcome in patients with a continuous-flow left ventricular assist device (LVAD) is currently not well understood. We conducted a systematic literature review and meta-analysis with an intention to summarize all published clinical evidence. We searched MEDLINE and EMBASE databases through March 2018 for studies that compared the outcomes in patients with LVAD and CRT. Read More

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http://dx.doi.org/10.1007/s10741-018-9740-xDOI Listing
September 2018
2 Reads

B-type natriuretic peptide levels and benign adiposity in obese heart failure patients.

Heart Fail Rev 2018 Sep 25. Epub 2018 Sep 25.

1st Cardiology Department, Hippokration General Hospital, Athens Medical School, Athens, Greece.

Obesity is a major risk factor for the development of chronic heart failure (CHF) and does not only pose diagnostic challenges, but also has prognostic implications for these patients. Paradoxically, obese patients with CHF have a better prognosis than thinner individuals. In recent years, it has been demonstrated that the adipose tissue, even in patients with HF, is not always detrimental, and that obesity may coexist with a phenotype of benign adiposity without systemic metabolic abnormalities. Read More

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http://dx.doi.org/10.1007/s10741-018-9739-3DOI Listing
September 2018
20 Reads

Clinical outcome of left ventricular multipoint pacing versus conventional biventricular pacing in cardiac resynchronization therapy: a systematic review and meta-analysis.

Heart Fail Rev 2018 Sep 12. Epub 2018 Sep 12.

School of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, DongDan SanTiao 9, DongCheng District, Beijing, People's Republic of China.

Cardiac resynchronization therapy (CRT) is an effective treatment for selected patients with systolic heart failure. Unlike conventional biventricular pacing (BIP), the left ventricular multipoint pacing (MPP) can increase the number of left ventricular pacing sites via a quadripolar lead positioned in the coronary sinus. This synthetic study was conducted to integratively and quantitatively evaluate the clinical outcome of MPP in comparison with BIP. Read More

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http://link.springer.com/10.1007/s10741-018-9737-5
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http://dx.doi.org/10.1007/s10741-018-9737-5DOI Listing
September 2018
11 Reads

Loop diuretics in chronic heart failure: how to manage congestion?

Heart Fail Rev 2019 Jan;24(1):17-30

Department of Cardiology, Maastricht University Medical Centre, Maastricht, The Netherlands.

Loop diuretics remain the cornerstone of congestion management in contemporary chronic heart failure care. However, their use is not supported by high quality data, and there is doubt about the safety in the outpatient heart failure setting. Still, congestion is related to a worse outcome, and there is general consensus among experts that congestion should not be tolerated in heart failure patients. Read More

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http://dx.doi.org/10.1007/s10741-018-9735-7DOI Listing
January 2019
11 Reads

Lanosteryl triterpenes from Protorhus longifolia as a cardioprotective agent: a mini review.

Heart Fail Rev 2019 Jan;24(1):155-166

Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council, Tygerberg, Cape Town, 7505, South Africa.

The epidemic of cardiovascular diseases is a global phenomenon that is exaggerated by the growing prevalence of diabetes mellitus. Coronary artery disease and diabetic cardiomyopathy are the major cardiovascular complications responsible for exacerbated myocardial infarction in diabetic individuals. Increasing research has identified hyperglycemia and hyperlipidemia as key factors driving the augmentation of oxidative stress and a pro-inflammatory response that usually results in increased fibrosis and reduced cardiac efficiency. Read More

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http://dx.doi.org/10.1007/s10741-018-9733-9DOI Listing
January 2019
34 Reads

Understanding non-response to cardiac resynchronisation therapy: common problems and potential solutions.

Heart Fail Rev 2019 Jan;24(1):41-54

Division of Imaging Sciences and Biomedical Engineering, King's College London, 4th Floor, North Wing, St Thomas' Hospital, London, SE1 7EH, UK.

Heart failure is a complex clinical syndrome associated with a significant morbidity and mortality burden. Reductions in left ventricular (LV) function trigger adaptive mechanisms, leading to structural changes within the LV and the potential development of dyssynchronous ventricular activation. This is the substrate targeted during cardiac resynchronisation therapy (CRT); however, around 30-50% of patients do not experience benefit from this treatment. Read More

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http://link.springer.com/10.1007/s10741-018-9734-8
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http://dx.doi.org/10.1007/s10741-018-9734-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313376PMC
January 2019
6 Reads

Electrical manipulation of the failing heart.

Heart Fail Rev 2018 Nov;23(6):885-896

Cardiology Institute, Policlinico S. Orsola-Malpighi, Bologna, Italy.

Chronic heart failure with reduced (≤ 40%) ejection fraction (HFrEF) poses a significant residual mortality risk despite modern optimal medical therapy. In the last decades, we have witnessed the introduction of breakthrough cardiac implantable electronic devices (CIED) aimed at addressing sudden cardiac death and HF progression in patients with HFrEF, leading to improved survival and functional capacity. Following their introduction, implantable cardioverter defibrillators (ICD) and cardiac resynchronization therapy (CRT) have undergone substantial technological improvements and have been investigated in different settings of HFrEF, some of which yielded controversial results. Read More

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http://dx.doi.org/10.1007/s10741-018-9732-xDOI Listing
November 2018
10 Reads

Transcatheter aortic valve replacement in patients with severe aortic stenosis and heart failure.

Heart Fail Rev 2018 Nov;23(6):821-829

Department of Medicine, Division of Cardiology Rhode Island Hospital, Warren Alpert Medical School of Brown University, 593 Eddy St, RIH APC814, Providence, RI, 02903, USA.

Severe aortic stenosis (AS) and heart failure (HF) represent an important and high-risk group of patients who are often referred for transcatheter aortic valve replacement (TAVR) due to high risk for surgical intervention. Thus far, randomized controlled trials have shown comparable outcomes between TAVR and surgical aortic valve replacement in patients with severe AS and heart failure with reduced ejection fraction. In the current review, we will discuss (1) the pathophysiology of HF in patients with severe AS, (2) role of imaging modalities in management, (3) role of biomarkers of HF on prognosis, (4) impact of other valvular heart diseases, (5) evidence from the contemporary trials on the role of TAVR in patients with severe AS and HF, and (6) future directions and research. Read More

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http://link.springer.com/10.1007/s10741-018-9726-8
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http://dx.doi.org/10.1007/s10741-018-9726-8DOI Listing
November 2018
22 Reads

Cardio-oncology: a new and developing sector of research and therapy in the field of cardiology.

Heart Fail Rev 2019 Jan;24(1):91-100

Cardiology Department, General Hospital of Elefsina 'Thriassio', Gennimata Ave, 19600, Athens, Greece.

Cardio-oncology is a new field of interest in cardiology that focuses on the detection, monitoring, and treatment of cardiovascular disease occurring as a side effect of chemotherapy and radiotherapy. Both cancer treatment modalities can cause cardiac dysfunction, a major cause of morbidity and mortality in the oncologic population. It is necessary to periodically monitor cancer patients under treatment, especially those receiving anthracyclines and trastuzumab (monoclonal antibody), using mainly 3D echocardiography to calculate left ventricular ejection fraction and to estimate myocardial deformation. Read More

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http://dx.doi.org/10.1007/s10741-018-9731-yDOI Listing
January 2019
2 Reads

Autonomic nervous system in Takotsubo syndrome.

Heart Fail Rev 2019 Jan;24(1):101-108

Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, 1b Banacha Street, 02-097, Warsaw, Poland.

Takotsubo syndrome (TTS) is an acute and usually reversible heart failure syndrome with symptoms resembling acute myocardial infarction, however, without obstruction of coronary arteries. In the majority of cases, TTS is preceded by emotional or physical stress and the disease concerns mainly postmenopausal women. Although several hypotheses have been introduced, the pathogenesis of TTS is controversial and still remains to be determined. Read More

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http://dx.doi.org/10.1007/s10741-018-9729-5DOI Listing
January 2019
5 Reads

Percutaneous support of the failing left and right ventricle-recommendations for the use of mechanical device therapy.

Heart Fail Rev 2018 Nov;23(6):831-839

Department of Internal Medicine I, University Hospital Jena, Friedrich-Schiller-University Jena, Jena, Germany.

Patients in cardiogenic shock and acute heart failure show high mortality and morbidity despite aggressive and invasive methods such as percutaneous coronary intervention and the use of mechanical support devices. Percutaneous implantation of active hemodynamic support is often the only option for hemodynamic stabilization of patients in cardiogenic shock. Therefore, current guidelines support the use of these devices. Read More

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http://dx.doi.org/10.1007/s10741-018-9730-zDOI Listing
November 2018
1 Read

Continuous versus intermittent administration of furosemide in acute decompensated heart failure: a systematic review and meta-analysis.

Heart Fail Rev 2019 Jan;24(1):31-39

Emergency and Critical Care Center, Kurashiki Central Hospital, 1-1-1 Miwa Kurashiki, Okayama, 710-8602, Japan.

Diuretic therapy is important in critically ill patients because fluid overload impairs organ function and increases mortality. Compared to intermittent administration, continuous infusion of loop diuretics is theoretically superior in terms of diuresis and electrolyte balance. However, the available evidence is susceptible to carryover diuretic effects and resistance in earlier crossover trials. Read More

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http://dx.doi.org/10.1007/s10741-018-9727-7DOI Listing
January 2019
1 Read
3.790 Impact Factor

Author's response to: letter to the editor.

Heart Fail Rev 2018 09;23(5):819

Bærum Hospital, Vestre Viken HF, Rud, Norway.

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http://dx.doi.org/10.1007/s10741-018-9728-6DOI Listing
September 2018
1 Read

Diagnostic and prognostic role of cardiac magnetic resonance in acute myocarditis.

Heart Fail Rev 2019 Jan;24(1):81-90

Fondazione Gabriele Monasterio CNR/Regione Toscana, via Giuseppe Moruzzi, 1, 56124, Pisa, Italy.

Acute myocarditis (AM) is commonly found in everyday clinical practice. Differential diagnosis between various causes of myocardial damage with non-obstructive coronary arteries can be cumbersome for clinician. Moreover, AM may be provoked by a number of different causes and clinical presentation can be heterogeneous with potential overlap going from asymptomatic or subclinical to severe heart failure, arrhythmias, and death. Read More

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http://link.springer.com/10.1007/s10741-018-9724-x
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http://dx.doi.org/10.1007/s10741-018-9724-xDOI Listing
January 2019
4 Reads

Flow-mediated dilation and heart failure: a review with implications to physical rehabilitation.

Heart Fail Rev 2018 Jul 11. Epub 2018 Jul 11.

Cardiopulmonary Physiotherapy Laboratory, Universidade Federal de Sao Carlos, Rod. Washington Luis, km 235-SP-310-CEP: 13565-905, Sao Carlos, Sao Paulo, Brazil.

Endothelial dysfunction plays as an important role on mismatch responses that occur during exercise in patients with congestive heart failure (CHF). However, cardiac rehabilitation, a core component of management of CHF patients, can improve endothelial function, contributing to reduce the morbidity and mortality of these patients. The primary aims of this review were to describe the importance of flow-mediated dilatation (FMD) as a non-invasive validation tool to assess endothelial dysfunction and to highlight the relevance of scientific studies that evaluated the effects of exercise interventions on peripheral vascular endothelial function as measured by FMD in patients with CHF with both preserved and reduced ejection fraction. Read More

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http://dx.doi.org/10.1007/s10741-018-9719-7DOI Listing
July 2018
17 Reads

Biomarkers for the identification of cardiac fibroblast and myofibroblast cells.

Heart Fail Rev 2018 Jul 10. Epub 2018 Jul 10.

School of Medical Sciences, Griffith University, Griffith, QLD, 4222, Australia.

Experimental research has recognized the importance of cardiac fibroblast and myofibroblast cells in heart repair and function. In a normal healthy heart, the cardiac fibroblast plays a central role in the structural, electrical, and chemical aspects within the heart. Interestingly, the transformation of cardiac fibroblast cells to cardiac myofibroblast cells is suspected to play a vital part in the development of heart failure. Read More

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http://link.springer.com/10.1007/s10741-018-9720-1
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http://dx.doi.org/10.1007/s10741-018-9720-1DOI Listing
July 2018
4 Reads

Letter to the Editor regarding the article "The heart failure burden of type 2 diabetes mellitus-a review of pathophysiology and interventions".

Heart Fail Rev 2018 09;23(5):817-818

Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

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http://dx.doi.org/10.1007/s10741-018-9725-9DOI Listing
September 2018
1 Read

Testosterone, myocardial function, and mortality.

Heart Fail Rev 2018 09;23(5):773-788

Clinical Center Stella Maris, Laboratory of Physiology of Exercise, Strada Rovereta 42, 47891, Falciano, Republic of San Marino.

The cardiovascular system is particularly sensitive to androgens, but some controversies exist regarding the effect of testosterone on the heart. While among anabolic abusers, cases of sudden cardiac death have been described, recently it was reported that low serum level of testosterone was correlated with increased risk of cardiovascular diseases (CVD) and mortality rate. This review aims to evaluate the effect of testosterone on myocardial tissue function, coronary artery disease (CAD), and death. Read More

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http://dx.doi.org/10.1007/s10741-018-9721-0DOI Listing
September 2018
1 Read

Prognostic value of T1 mapping and extracellular volume fraction in cardiovascular disease: a systematic review and meta-analysis.

Heart Fail Rev 2018 09;23(5):723-731

Department of Magnetic Resonance Imaging, Fuwai Hospital,Cardiovascular Imaging and Intervention Center, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167, Beilishi Road, Beijing, 100037, China.

T1 mapping and extracellular volume (ECV) fraction are useful new magnetic resonance imaging (MRI) techniques to evaluate myocardial fibrosis; however, their prognostic value has not been well described. In this study, a systematic review and meta-analysis evaluating the prognostic value of these techniques is performed in patients with ischemic and non-ischemic cardiomyopathy. PubMed, Cochrane CENTRAL, and Meta-Register of Controlled Trials were searched for studies that utilized T1 mapping and ECV and that also had ≥ 12 months of follow-up data. Read More

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http://dx.doi.org/10.1007/s10741-018-9718-8DOI Listing
September 2018
7 Reads