279 results match your criteria Heart Disease[Journal]


Ximelagatran: a new oral anticoagulant.

Heart Dis 2003 Nov-Dec;5(6):397-408

University of New Mexico College of Pharmacy, Albuquerque, NM 87131, USA.

Although there have been many significant advances over the last 50 years with regards to anticoagulant therapy, warfarin remains the definitive standard for the long-term prevention of thromboembolic events in many patients at risk for these complications. Although effective, warfarin has a narrow therapeutic window, necessitating frequent laboratory monitoring for anticoagulant effect. Ximelagatran is an investigational anticoagulant that directly inhibits thrombin, unlike heparin or warfarin, which are indirect inhibitors. Read More

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http://dx.doi.org/10.1097/01.hdx.0000099777.39577.e8DOI Listing
February 2004
9 Reads

Long-term (2-4 year) weight reduction with metformin plus carbohydrate-modified diet in euglycemic, hyperinsulinemic, midlife women (Syndrome W).

Heart Dis 2003 Nov-Dec;5(6):384-92

Divisions of Endocrinology, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA.

Long-term weight reduction remains the ultimate objective and challenge of obesity management. Few long-term dietary or pharmacointervention studies have been conducted and there is a critical need for long-range treatment strategies that are effective, safe, and acceptable. The authors conducted a retrospective cohort analysis of 21 euglycemic, hyperinsulinemic women with progressive, refractory, midlife weight gain (Syndrome W) who had previously lost weight (> or =10% reduction from baseline) with a comprehensive 1-year treatment program that included metformin and a hypocaloric, carbohydrate-modified (low-glycemic index) diet, as well as, other lifestyle modifications. Read More

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February 2004
7 Reads

A comparison of humanistic qualities among medical students, residents, and faculty physicians in internal medicine.

Heart Dis 2003 Nov-Dec;5(6):380-3

Division of General Internal Medicine, New York Medical College/Westchester Medical Center, Valhalla, NY 10595, USA.

Humanistic qualities of integrity, respect and compassion are important components of medical education. Studies, however, suggest that students may not perceive their faculty physicians as humanistic. Knowing how the perception of humanistic qualities varies by training level may offer insight on how we teach humanism. Read More

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https://insights.ovid.com/crossref?an=00132580-200311000-000
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http://dx.doi.org/10.1097/01.hdx.0000098641.24830.86DOI Listing
February 2004
8 Reads

Effect of carotid angioplasty-stenting on short-term mortality and stroke.

Heart Dis 2003 Nov-Dec;5(6):378-9

Department of Medicine, Division of Cardiology, New York Medical College, Valhalla, NY 10595, USA.

Carotid angioplasty-stenting (CAS) was attempted in 78 carotid arteries in 74 patients (45 men and 29 women) with occlusive internal carotid arterial disease and was technically successful in 77 of 78 arteries (99%). Of 77 arteries with successful CAS, 58 (75%) were asymptomatic, 15 (20%) were associated with transient ischemic attacks or amaurosis, and 4 (5%) were associated with prior stroke. Of 77 arteries with successful CAS, 34 (44%) were associated with prior carotid endarterectomy with recurrence of occlusive carotid disease, and 43 arteries (56%) were associated with primary CAS. Read More

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https://insights.ovid.com/crossref?an=00132580-200311000-000
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http://dx.doi.org/10.1097/01.hdx.0000098360.69268.1bDOI Listing
February 2004
7 Reads

Evidence for the extrapulmonary localization of inhaled nitric oxide.

Heart Dis 2003 Nov-Dec;5(6):372-7

LPPCE, Faculty of Medicine, (IFR 100) Dijon, France.

Inhaled nitric oxide (NO) has emerged as a promising pulmonary vasodilator to treat pulmonary hypertension associated with heart disease and ventilation/perfusion mismatching. However, the pharmacokinetics of inhaled NO still remains obscure and its cardiopulmonary selectivity appears to be increasingly under debate. In the present study measured NO content and levels of cyclic guanosine 3',5'monophosphate (cGMP), a mediator of NO-induced vasodilation, in a variety of organs from rats subjected to NO inhalation. Read More

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http://dx.doi.org/10.1097/01.hdx.0000098613.53486.08DOI Listing
February 2004
4 Reads

Timing and duration of administration are crucial for antiinfarct effect of AMP 579 infused at reperfusion in rabbit heart.

Heart Dis 2003 Nov-Dec;5(6):368-71

Departments of Physiology,University of South Alabama, College of Medicine, Mobile, AL 36688, USA.

The adenosine A(1)/A(2) receptor agonist AMP 579 has been reported to protect the heart against infarction even when administered after the onset of ischemia. The present study explored both the timing and the duration of treatment required to limit infarct size in in situ rabbit hearts subjected to 30 min of regional ischemia and 3 hours of reperfusion. In groups 1 and 2, AMP 579 was infused from 10 min before reperfusion and continued for either 30 or 40 min. Read More

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http://dx.doi.org/10.1097/01.hdx.0000098614.29006.a7DOI Listing
February 2004
8 Reads

Arrhythmogenic right ventricular dysplasia in the elderly.

Heart Dis 2003 Nov-Dec;5(6):393-6

Department of Internal Medicine, Division of Cardiology, Jackson Memorial Hospital, University of Miami School of Medicine, Miami, FL 33101, USA.

Arrhythmogenic right ventricular dysplasia (ARVD) is a form of cardiomyopathy characterized by fibrofatty infiltration of the right ventricle that leads to cardiac arrhythmias, usually sustained ventricular tachycardia or ventricular fibrillation. ARVD typically becomes recognized in young adults. The authors report a case of an octogenarian in whom third-degree atrioventricular block, low cardiac output syndrome, and failure to capture the pacer stimuli developed. Read More

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http://dx.doi.org/10.1097/01.hdx.0000089782.50317.54DOI Listing
February 2004
5 Reads

Eplerenone: a selective aldosterone receptor antagonist for hypertension and heart failure.

Heart Dis 2003 Sep-Oct;5(5):354-63

South Texas Veterans Health Care System, San Antonio, TX, USA.

Aldosterone has been implicated for many years as an important substance in the pathogenesis of heart disease. Elevated aldosterone concentrations have been documented in patients with hypertension and heart failure, leading to the use of aldosterone antagonists for the treatment of these conditions. Spironolactone has been used for nearly 2 decades for the treatment of hypertension, and more recently, has become a standard agent for the treatment of systolic heart failure. Read More

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http://dx.doi.org/10.1097/01.hdx.0000089783.30450.cbDOI Listing
January 2004
6 Reads

Valvular heart disease and systemic lupus erythematosus: therapeutic implications.

Heart Dis 2003 Sep-Oct;5(5):349-53

Department of Medicine/Internal Medicine, New York Medical College/Metropolitan Hospital Center, 1901 First Avenue, New York, NY 10029, USA.

Valvular involvement is the most encountered form of heart disease in systemic lupus erythematosus (SLE). Immunoglobulin and complement deposition in the valvular structure will subsequently lead to Libman-Sacks vegetations, valve thickening, and valve regurgitation. Valvular stenosis is rarely seen. Read More

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http://dx.doi.org/10.1097/01.hdx.0000089834.97829.5eDOI Listing
January 2004
3 Reads

Contemporary management of "high-risk" patients with carotid stenosis.

Heart Dis 2003 Sep-Oct;5(5):345-8

Division of Vascular Surgery, Stony Brook University Hospital, Stony Brook, NY, USA.

The concept of a "high-risk" carotid endarterectomy patient has been suggested in an effort to justify the application of carotid angioplasty and stenting outside of clinical trials. Contemporary results of carotid endarterectomy in this subgroup of patients would argue against the existence of a high-risk patient. Until randomized prospective trials establish the role of carotid angioplasty and stenting in carotid bifurcation disease, this new technology should be restricted to recurrent and radiation-induced disease. Read More

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http://dx.doi.org/10.1097/01.hdx.0000089835.03588.26DOI Listing
January 2004
5 Reads

Screening coronary arteriography in the primary prevention of coronary artery disease.

Heart Dis 2003 Sep-Oct;5(5):335-44

Department of Cardiology, Westchester Medical Center, Valhalla, NY 10595, USA.

Recent studies indicate an expansion of the population eligible for primary prevention of coronary artery disease with lipid-lowering therapy. This change has led to the unnecessary treatment of many individuals and an overall decreased effectiveness of medication with potentially significant side effects. If instead, the asymptomatic population is screened for the presence of early coronary artery disease (CAD), lipid lowering can be targeted to those who can truly benefit. Read More

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http://dx.doi.org/10.1097/01.hdx.0000080717.15994.64DOI Listing
January 2004
6 Reads

Using insulin as a drug rather than as a replacement hormone during acute illness: a new paradigm.

Heart Dis 2003 Sep-Oct;5(5):323-33

Division of Endocrinology and Metabolism, Montefiore Medical Center/Albert Einstein College of Medicine, 1825 Eastchester Road, Bronx, NY 10461, USA.

The direct correlation between glucose levels and cardiovascular disease in individuals with type 2 diabetes can now be applied to individuals that share an abnormal metabolic milieu similar to that found in central obesity, the metabolic syndrome, and type 2 diabetes. Premature macrovascular complications with a very high morbidity and mortality rate can be found in these nondiabetic populations. The typical phenotype has visceral or central obesity, excess of free fatty acids, insulin resistance, increased insulin secretion, and hypertension. Read More

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http://dx.doi.org/10.1097/01.hdx.0000089839.13906.63DOI Listing
January 2004
3 Reads

Association of transesophageal echocardiographic findings with the site of arterial occlusion in patients with thromboembolic stroke.

Heart Dis 2003 Sep-Oct;5(5):320-2

Cardiology Division, Westchester Medical Center/New York Medical College, Macy Pavilion, Room 138, Valhalla, NY 10595, USA.

The authors investigated the association of transesophageal echocardiographic findings with the site of arterial occlusion in patients who underwent transesophageal echocardiography because of thromboembolic stroke and in whom the site of arterial occlusion was diagnosed by computerized axial tomography. The study population included 101 patients (mean age 59 +/- 15 years) with thromboembolic stroke and 101 randomly selected age-matched and sex-matched control without stroke. Transesophageal echocardiographic findings that were significantly higher in the patients with thromboembolic stroke than in the control group were vegetations on the aortic or mitral valve (9% versus 1%, P < 0. Read More

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http://dx.doi.org/10.1097/01.hdx.0000080715.97676.1bDOI Listing
January 2004
3 Reads

Physicians' perceptions of the effect of nonclinical factors on coronary revascularization.

Heart Dis 2003 Sep-Oct;5(5):313-9

Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Belfer 1306A, 1300 Morris Park Avenue, Bronx, NY 10461, USA..

The main objective of this study was to determine if physicians perceive that extracardiac or nonclinical factors such as patients' financial status, lifestyle, or trust in the physician impact coronary revascularization decisions. A self-administered questionnaire was developed and mailed to a random sample of 1200 family physicians, internists, cardiologists, and cardiothoracic surgeons who were active members of well-respected medical organizations in the United States. Survey questions were rated on a 4- and 5-point Likert scale to determine whether physicians perceive that nonclinical factors impede or facilitate coronary revascularization, respectively. Read More

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http://dx.doi.org/10.1097/01.hdx.0000089868.93202.f0DOI Listing
January 2004
5 Reads

The activation pattern of the antioxidant enzymes in the right ventricle of rat in response to pressure overload is of heart failure type.

Heart Dis 2003 Sep-Oct;5(5):308-12

Laboratory of Experimental Cardiovascular Physiopathology and Pharmacology (I.F.R. No 100), Faculties of Medicine and Pharmacy, University of Burgundy, 21079 Dijon, France.

In the left ventricle subjected to pressure overload activity, the antioxidant enzymes increased at the hyperfunctional stage. During the transition to heart failure, these enzymes are down-regulated, oxidative stress increases, and apoptosis progresses. Maladaptative activation of the antioxidant enzymes at an early stage may contribute to the intrinsic vulnerability of right ventricle to pressure overload. Read More

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http://dx.doi.org/10.1097/01.hdx.0000089836.03515.a9DOI Listing
January 2004
8 Reads

JNC 7: has the definition of hypertension changed?

Authors:
Domenic A Sica

Heart Dis 2003 Sep-Oct;5(5):305-7

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http://dx.doi.org/10.1097/01.hdx.0000089784.35027.8aDOI Listing
January 2004
3 Reads

Fondaparinux: a synthetic selective factor-Xa inhibitor.

Authors:
Nina N Wong

Heart Dis 2003 Jul-Aug;5(4):295-302

Department of Pharmacy, Montefiore Medical Center, Bronx, NY 10467, USA.

Fondaparinux is the first synthetic selective factor-Xa inhibitor. It is indicated for prophylaxis of deep vein thrombosis in patients undergoing hip fracture, hip replacement, and knee replacement surgeries. In these patients, fondaparinux appears to be more efficacious than enoxaparin. Read More

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http://dx.doi.org/10.1097/01.hdx.0000080719.75044.b0DOI Listing
October 2003
4 Reads

Epidemiology, pathophysiology, prognosis, and treatment of systolic and diastolic heart failure in elderly patients.

Authors:
Wilbert S Aronow

Heart Dis 2003 Jul-Aug;5(4):279-94

Department of Medicine, Cardiology Division, Westchester Medical Center/New York Medical College, Valhalla, NY, USA.

American College of Cardiology/American Heart Association class I recommendations for treating patients with heart failure (HF) and abnormal left ventricular ejection fraction are diuretics in patients with fluid retention, an angiotensin-converting enzyme (ACE) inhibitor unless contraindicated, a beta-blocker unless contraindicated, digoxin for the treatment of symptoms of HF, and withdrawal of drugs known to precipitate or aggravate HF such as nonsteroidal anti-inflammatory drugs, calcium channel blockers, and most antiarrhythmic drugs. Class II(a) recommendations for treating HF with abnormal left ventricular ejection fraction are spironolactone in patients with class IV symptoms, preserved renal function, and normal serum potassium; exercise training as an adjunctive approach to improve clinical status in ambulatory patients; an angiotensin receptor blocker in patients who cannot be given an ACE inhibitor because of cough, rash, altered taste sensation, or angioedema; and hydralazine plus nitrates in patients being treated with diuretics, a beta-blocker, and digoxin who cannot be given an ACE inhibitor or an angiotensin receptor blocker because of hypotension or renal insufficiency. Patients with diastolic HF should be treated with cautious use of diuretics and with a beta-blocker. Read More

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http://dx.doi.org/10.1097/01.hdx.0000080714.87750.48DOI Listing
October 2003
4 Reads

Osteopathic manipulative medicine in the treatment of hypertension: an alternative, conventional approach.

Heart Dis 2003 Jul-Aug;5(4):272-8

Department of Osteopathic Medicine, New York College of Osteopathic Medicine, Old Westbury, NY 11568, USA.

The branch of medicine known as osteopathy was founded by Andrew Taylor Still in the mid to late 19th century. Osteopathy is a philosophy of medicine. Osteopathic physicians use techniques collectively referred to as osteopathic manipulative medicine (OMM). Read More

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http://dx.doi.org/10.1097/01.hdx.0000080718.70719.88DOI Listing
October 2003
62 Reads

Cardiovascular manifestations of substance abuse: part 2: alcohol, amphetamines, heroin, cannabis, and caffeine.

Heart Dis 2003 Jul-Aug;5(4):253-71

Department of Medicine, The New York Medical College/Westchester Medical Center, Valhalla, NY 10595, USA.

The abuse of alcohol is associated with chronic cardiomyopathy, hypertension, and arrhythmia. Abstinence or using alcohol in moderation can reverse these cardiovascular problems. Alcohol is also distinguished among the substances of abuse by having possible protective effects against coronary artery disease and stroke when used in moderate amounts. Read More

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http://dx.doi.org/10.1097/01.hdx.0000080713.09303.a6DOI Listing
October 2003
53 Reads

Does QTc interval predict the response to beta-blockers and calcium channel blockers in hypertensives?

Heart Dis 2003 Jul-Aug;5(4):244-52

Department of Clinical Pharmacology, Centre hospitalier de l'Université de Montréal-Hôtel-Dieu, Montréal, Qc, Canada.

The QT interval corrected for heart rate (QTc) is believed to reflect sympathovagal balance. It has also been established that beta-blockers and dihydropyridine-type calcium channel blockers (DHPCCB) influence the autonomic nervous system. This study tested the hypothesis that QTc interval length is a predictor of the blood pressure reduction induced by beta1-selective beta-blockers or DHPCCB. Read More

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October 2003
9 Reads

Heart failure in the elderly.

Authors:
Marc Klapholz

Heart Dis 2003 Jul-Aug;5(4):241-3

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http://dx.doi.org/10.1097/01.hdx.0000080720.26387.89DOI Listing
October 2003
4 Reads

Insulin glargine: a new once-daily basal insulin for the management of type 1 and type 2 diabetes mellitus.

Authors:
Sum Lam

Heart Dis 2003 May-Jun;5(3):231-40

Geriatric Research, Education & Clinical Center (GRECC), Veterans Affairs Medical Center, Durham, NC, USA.

Optimal glucose control is the primary goal for treating diabetes mellitus and preventing long-term complications of diabetes, such as coronary heart disease, nephropathy, neuropathy and retinopathy. Insulin glargine is a novel, long-acting human insulin analog that is indicated in type 1 diabetic patients aged >or=6, or in type 2 diabetic patients who require basal insulin for glycemic control. Insulin glargine is a recombinant insulin with a modified structure that allows it to dissolve in an acidic solution, but to precipitate in the physiological subcutaneous tissue forming a depot effect. Read More

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http://dx.doi.org/10.1097/01.HDX.0000074514.20750.57DOI Listing
September 2003
8 Reads

Atrial myxoma: case report and a review of the literature.

Heart Dis 2003 May-Jun;5(3):224-30

Departments of Medicine, University of South Florida College of Medicine and the James A Haley VA Hospital, Tampa, FL 33612, USA.

Atrial myxomas are the most common benign primary tumor of the heart and occur in as many as 3 in 1000 patients. These tumors are a major cause of patient morbidity and mortality. Although the majority of atrial myxomas occur in the left atrium, 3 separate familial myxoma syndromes can result in multiple myxomas in atypical locations. Read More

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September 2003
34 Reads

Natriuretic peptides: biochemistry, physiology, and therapeutic role in heart failure.

Heart Dis 2003 May-Jun;5(3):215-23

Division of Cardiovascular Diseases, UMDNJ-New Jersey Medical School, Newark, NJ, USA.

Cardiac natriuretic peptides are a family of structurally related peptides that are important in sodium and volume homeostasis. They consist of atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide and are elevated in patients with left ventricular dysfunction. In contrast with vasoconstrictive hormones, such as norepinephrine, angiotensin II, and arginine vasopressin, which worsen the physiological milieu in patients with left ventricular dysfunction and heart failure, the natriuretic peptides ameliorate these effects by promoting natriuresis, diuresis, peripheral vasodilation, and by inhibiting the renin-angiotensin system. Read More

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http://dx.doi.org/10.1097/01.HDX.0000074517.30102.64DOI Listing
September 2003
6 Reads

Gender, ethnicity, and genes in cardiovascular disease. Part 2: implications for pharmacotherapy.

Heart Dis 2003 May-Jun;5(3):202-14

Department of Medicine, Jacobi Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.

Women are underrepresented in clinical trials. Lower doses of beta-blockers are required for Southeast Asians. ACE and ARB's are teratogenic in the second trimester. Read More

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http://dx.doi.org/10.1097/01.HDX.0000074437.07268.00DOI Listing
September 2003
4 Reads

Cardiovascular manifestations of substance abuse part 1: cocaine.

Heart Dis 2003 May-Jun;5(3):187-201

Departments of Medicine, The New York Medical College/Westchester Medical Center, Valhalla, NY 10595, USA.

Substance abuse with cocaine is associated with multiple cardiovascular conditions, including myocardial infarction, dissection, left ventricular hypertrophy, arrhythmias, sudden death, and cardiomyopathy. Cocaine has effects to potentiate the physiologic actions of catecholamines and has direct effects on voltage-dependent sodium ion channels related to local anesthetic properties. The effects of cocaine can be augmented with concomitant alcohol consumption. Read More

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http://dx.doi.org/10.1097/01.hdx.0000074519.43281.faDOI Listing
September 2003
4 Reads

Circumflex coronary artery occlusion after blunt chest trauma.

Heart Dis 2003 May-Jun;5(3):184-6

Department of General Internal Medicine, New York Medical College/Westchester Medical Center, Valhalla, NY, USA.

A 32-year-old white male police officer suffered blunt trauma to the anterior chest wall during a routine training session. This was accompanied by the precipitous onset of chest discomfort. There was no previous history of any cardiac risk factors. Read More

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http://dx.doi.org/10.1097/01.HDX.0000074513.94316.d8DOI Listing
September 2003
4 Reads

Inflammation at a glance: erythrocyte adhesiveness/aggregation test to reveal the presence of inflammation in people with atherothrombosis.

Heart Dis 2003 May-Jun;5(3):182-3

Departments of Geriatrics, Beit Rivka Geriatric Center and Internal Medicine "D", Tel Aviv Sourasky Medical Center, and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

The erythrocyte adhesiveness/aggregation test is a new biomarker to detect low-grade inflammation in patients with atherothrombosis. In a group of 30 individuals with an acute ischemic event, the variability of EAAT during a follow-up period was similar to those obtained for other commonly used markers of the acute phase response, suggesting the potential clinical use of this novel marker. Read More

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https://insights.ovid.com/crossref?an=00132580-200305000-000
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http://dx.doi.org/10.1097/01.HDX.0000074516.58801.7aDOI Listing
September 2003
7 Reads

Pharmacokinetics of propranolol after single and multiple dosing with sustained release propranolol or propranolol CR (innopran XL) , a new chronotherapeutic formulation.

Heart Dis 2003 May-Jun;5(3):176-81

Section of Clinical Pharmacology and Hypertension, Division of Nephrology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298-0160, USA.

Blood pressure rises rapidly upon waking and may be responsible, in part, for the increased incidence of myocardial infarction and stroke during the morning hours. Current formulations and dosing of antihypertensive drugs do not provide maximum coverage during this vulnerable period. This study was performed to demonstrate that propranolol CR (Innopran XL), a novel chronotherapeutic formulation of propranolol designed for nighttime dosing, has appropriate pharmacokinetics to provide maximum cardioprotective effect in the morning. Read More

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http://dx.doi.org/10.1097/01.HDX.0000074436.09658.3bDOI Listing
September 2003
3 Reads

ALLHAT: is the final answer in?

Authors:
Domenic A Sica

Heart Dis 2003 May-Jun;5(3):171-5

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http://dx.doi.org/10.1097/01.HDX.0000074435.50685.4aDOI Listing
September 2003
3 Reads

Bosentan.

Authors:
Judy W M Cheng

Heart Dis 2003 Mar-Apr;5(2):161-9

Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, and Mount Sinai Medical Center, New York, NY 10029, USA.

Bosentan is the first endothelin (ET) receptor antagonist approved by the Food and Drug Administration for the management of pulmonary arterial hypertension (PAH). In patients with World Health Organization Class III and IV PAH, bosentan has demonstrated improvement in dyspnea and exercise tolerance. ET also plays an important role in the pathophysiology of different vascular diseases. Read More

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August 2003
6 Reads

Cardiovascular effects of selective serotonin reuptake inhibitors and other novel antidepressants.

Heart Dis 2003 Mar-Apr;5(2):153-60

Lakeland Mental Health Center and Department of Psychiatry and Behavioral Science, Fergus Falls, MN 56537, USA.

This paper reviews the current knowledge of cardiovascular effects of the most commonly used novel antidepressants and their possible interactions with cardiovascular medications. The literature was reviewed through Medline 1980-2001. Materials were located by using terms such as SSRIs, individual names of novel antidepressants matched with terms like cardiovascular effects, cardiovascular diseases, cardiovascular risk factors, etc. Read More

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August 2003
3 Reads

Clopidogrel in the management of ischemic heart disease.

Heart Dis 2003 Mar-Apr;5(2):144-52

Department of Medicine, Bronx VA Medical Center, Bronx, NY 10468, USA.

Ischemic heart disease (IHD) represents a pathophysiologic continuum consisting of stable angina, unstable angina, non-ST-segment elevation myocardial infarction, and ST-segment elevation myocardial infarction. Patients who develop a change in their usual stable pattern of ischemia are classified as having an acute coronary syndrome, which includes patients with unstable angina, non-ST-segment elevation myocardial infarction, and ST-segment elevation myocardial infarction. Such progression from a stable to an unstable state is believed to result from disruption of an atherosclerotic plaque with subsequent platelet aggregation and thrombus formation. Read More

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August 2003
7 Reads

Gender, ethnicity and genetics in cardiovascular disease: part 1: Basic principles.

Heart Dis 2003 Mar-Apr;5(2):129-43

Department of Medicine, Jacobi Medical Center, Brooklyn, NY, USA.

Prior to 1993, most drug efficacy and safety trials were conducted in white males, although gender and racial differences in pharmacodynamics and pharmacokinetics have been documented since the early 1900s. Over the last 2 decades, supported by the FDA and legislation, attempts to include more women and minorities in clinical drug trials have been made, with limited success. Yet, there are important differences in pathophysiology and pharmacogenetics, as well as pharmacotherapeutic effectiveness. Read More

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August 2003
4 Reads

Diabetes mellitus and coronary artery disease: therapeutic considerations.

Heart Dis 2003 Mar-Apr;5(2):119-28

Division of Cardiology, Department of Medicine, Westchester Medical Center/New York Medical College, Valhalla, New York 10595, USA.

Diabetes mellitus affects about 6% of the U.S. population and represents a significant public health challenge, with numbers of those affected increasing every year. Read More

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August 2003
3 Reads

Aldosterone and aldosterone antagonism in cardiovascular disease: focus on eplerenone (Inspra).

Heart Dis 2003 Mar-Apr;5(2):102-18

Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA.

Aldosterone has long been known to mediate water and electrolyte balance by acting on mineralocorticoid receptors in the kidneys. However, recent studies have demonstrated the presence of these receptors in nonclassical locations, including the brain, blood vessels, and the heart. This finding suggests that aldosterone may play a larger role than once appreciated in normal physiologic function and cardiovascular disease. Read More

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August 2003
4 Reads

Nicotine gum-induced atrial fibrillation.

Heart Dis 2003 Mar-Apr;5(2):100-1

Cardiology Division, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA.

A 39-year-old man with no prior history of atrial fibrillation was hospitalized with atrial fibrillation and a rapid ventricular rate. For the 7 months before presentation, he had been chewing nicotine polacrilex gum on his own. The week he first developed palpitations, he was chewing more than 1 piece of nicotine Polacrilex gum per hour during work. Read More

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August 2003
3 Reads

Breath markers of oxidative stress in patients with unstable angina.

Heart Dis 2003 Mar-Apr;5(2):95-9

Menssana Research Inc, Fort Lee, NJ 07024, USA.

Cardiac chest pain is accompanied by oxidative stress, which generates alkanes and other volatile organic compounds (VOCs). These VOCs are excreted in the breath and could potentially provide a rational diagnostic marker of disease. The breath methylated alkane contour (BMAC), a 3-dimensional surface plot of C4-C20 alkanes and monomethylated alkanes, provides a comprehensive set of markers of oxidative stress. Read More

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http://www.menssanaresearch.com/angina.pdf
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August 2003
4 Reads

Influence of gender and reported alcohol intake on mortality in nonischemic dilated cardiomyopathy.

Heart Dis 2003 Mar-Apr;5(2):89-94

Department of Clinical Cardiology, Royal Brompton Hospital, London, United Kingdom.

Between 1994-1998, we retrospectively studied a cohort of 396 consecutive patients with dilated cardiomyopathy, mean age 53 +/- 15 years, 74% men. The history of alcohol intake was abstracted from the medical records. During a follow-up period of 42 +/- 26 months, 83 (76% men) patients died and 15 (80% men) underwent cardiac transplantation. Read More

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August 2003
4 Reads

Aldosterone receptor blockade: a therapy resurrected.

Authors:
Domenic A Sica

Heart Dis 2003 Mar-Apr;5(2):85-8

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August 2003
4 Reads

Rosuvastatin: a new HMG-CoA reductase inhibitor for the treatment of hypercholesterolemia.

Authors:
Angela Cheng-Lai

Heart Dis 2003 Jan-Feb;5(1):72-8

Department of Pharmacy, Montefiore Medical Center, Bronx, New York 10461, USA.

Because of their excellent tolerability and their positive impact on lipid parameters, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have become the drugs of first choice for many patients with dyslipidemia. Rosuvastatin is an investigational statin in the U.S. Read More

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http://dx.doi.org/10.1097/01.HDX.0000050417.89309.F8DOI Listing
May 2003
4 Reads

Anemia and hypocholesterolemia.

Heart Dis 2003 Jan-Feb;5(1):65-71

Department of Medicine, Jacobi Hospital Medical Center-Albert Einstein College of Medicine, Bronx, New York 10461, USA.

The authors reviewed the available data on the relationship between hypocholesterolemia and anemia with various etiologies. The data were collected from sources identified by a MEDLINE search of English-language literature published between 1966 and 2001 and bibliographies of relevant articles. The study selection included primary research articles, metaanalyses, and abstracts concerning the relation between hypocholesterolemia and anemia. Read More

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http://dx.doi.org/10.1097/01.HDX.0000050420.79522.09DOI Listing
May 2003
6 Reads

Drug treatment of orthostatic hypotension and vasovagal syncope.

Heart Dis 2003 Jan-Feb;5(1):49-64

Department of Medicine, New York Medical College/Westchester Medical Center, Valhalla, New York 10595, USA.

Orthostatic hypotension is a common problem, estimated to occur in 5 out of every 1000 individuals and in as many as 7% to 17% of patients in an acute care setting. Moreover, orthostatic hypotension may be more prominent in elderly patients due to the increased intake of vasoactive medications and concomitant decrease in physiologic function, such as baroreceptor sensitivity, often seen with aging. Orthostatic hypotension is a fall in blood pressure on assuming an upright position. Read More

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http://dx.doi.org/10.1097/01.HDX.0000050416.53995.43DOI Listing
May 2003
5 Reads

Pharmacotherapeutic considerations in anesthesia.

Heart Dis 2003 Jan-Feb;5(1):34-48

Division of Cardiac Anesthesia, Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.

This article focuses on new findings leading to improved understanding of the pathophysiology and mechanisms of potential drug interactions between anesthetic drugs or techniques and cardiovascular medications in patients scheduled for surgery. Only the most frequently used drugs are reviewed. Elective surgery provides the luxury to consider these risks and alter therapy accordingly. Read More

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http://dx.doi.org/10.1097/01.HDX.0000050410.54258.24DOI Listing
May 2003
5 Reads

Pharmacotherapy of diabetes mellitus: implications for the prevention and treatment of cardiovascular disease.

Heart Dis 2003 Jan-Feb;5(1):18-33

Department of Medicine, The Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York 10461-2373, USA.

Diabetes mellitus in adults is associated with an increased risk of premature vascular disease and a higher mortality rate. The presence of other risk factors, often seen in diabetic patients, such as systemic hypertension, augments the rate of vascular diseases. Evidence is growing that tight control of hyperglycemia using insulin and/or oral hypoglycemic agents will modify this risk. Read More

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http://dx.doi.org/10.1097/01.HDX.0000050411.62103.F5DOI Listing
May 2003
3 Reads

Cerebral hyperperfusion after angioplasty and stenting of a totally occluded left subclavian artery: a case report.

Heart Dis 2003 Jan-Feb;5(1):15-7

Department of Medicine, New York Medical College/Westchester Medical Center, Valhalla, New York, USA.

Cerebral hyperperfusion syndrome is documented after angioplasty of carotid and vertebral artery lesions. The authors report the first instance of cerebral hyperperfusion syndrome in the posterior cerebral circulation after angioplasty and stenting of a totally occluded left subclavian artery. Read More

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http://dx.doi.org/10.1097/01.HDX.0000050409.81342.EDDOI Listing
May 2003
3 Reads

Racial variations in cardiology care among hospitalized older heart failure patients.

Heart Dis 2003 Jan-Feb;5(1):8-14

Department of Medicine, University of Alabama at Birmingham (UAB), AL 35294-2041, USA.

In this retrospective follow-up study, the authors examined the association between race and the receipt of cardiology care in 1062 Medicare beneficiaries 65 years of age and older who were hospitalized with heart failure. The primary outcome measure was receipt of care from a cardiologist (via admission or consultation). Using logistic regression analyses, crude and adjusted odds ratios (OR) and 95% confidence intervals (95%CI) of receipt of cardiology care were estimated for nonwhite versus white patients. Read More

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http://dx.doi.org/10.1097/01.HDX.0000050408.07809.45DOI Listing
May 2003
5 Reads

hsCRP and HDL effects of statins trial (CHEST): rapid effect of statin therapy on C-reactive protein and high-density lipoprotein levels A clinical investigation.

Heart Dis 2003 Jan-Feb;5(1):2-7

Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA.

Inflammation contributes to the pathogenesis of coronary heart disease and elevated serum levels of C-reactive protein (CRP) are independently associated with increased coronary risk. This study assessed whether there were differences in the effects on CRP and high-density lipoprotein (HDL) cholesterol levels among patients treated with three common statins. In a prospective, observational study, 80 dyslipidemic adults without evidence of cardiovascular disease were treated with 10 mg atorvastatin (A), 20 mg simvastatin (S), or 40 mg pravastatin (P) daily. Read More

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http://dx.doi.org/10.1097/01.HDX.0000050407.62572.DEDOI Listing
May 2003
6 Reads