10,265 results match your criteria Heart British Cardiac Society[Journal]


Left ventricular geometry and risk of incident hypertension.

Heart 2019 Apr 17. Epub 2019 Apr 17.

Department of Preventive Medicine, School of Medicine, Kyung Hee University, Dongdaemun-gu, Republic of Korea.

Objective: Left ventricular (LV) geometry change is an independent predictor for cardiovascular disease. However, data are equivocal on the association of echocardiographic parameters of LV geometry with incident hypertension. Thus, we were to investigate the risk of hypertension according to the baseline echocardiographic parameters of LV geometry. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314657DOI Listing

Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease.

Heart 2019 Apr 15. Epub 2019 Apr 15.

Division of Primary Care, University of Nottingham, Nottingham, UK.

Objective: To assess low-density lipoprotein cholesterol (LDL-C) response in patients after initiation of statins, and future risk of cardiovascular disease (CVD).

Methods: Prospective cohort study of 165 411 primary care patients, from the UK Clinical Practice Research Datalink, who were free of CVD before statin initiation, and had at least one pre-treatment LDL-C within 12 months before, and one post-treatment LDL-C within 24 months after, statin initiation. Based on current national guidelines, <40% reduction in baseline LDL-C within 24 months was classified as a sub-optimal statin response. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314253DOI Listing

Statin dose in primary prevention: aim for the target!

Heart 2019 Apr 15. Epub 2019 Apr 15.

Hospital Israelita Albert Einstein, São Paulo, Sao Paulo, Brazil.

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http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2019-314723
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http://dx.doi.org/10.1136/heartjnl-2019-314723DOI Listing
April 2019
2 Reads

Informing on individual cardiovascular risk: from wishful thinking to hard facts.

Heart 2019 Apr 10. Epub 2019 Apr 10.

Psychiatrie, Hopital Europeen Georges Pompidou, Paris, France.

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http://dx.doi.org/10.1136/heartjnl-2019-314814DOI Listing
April 2019
1 Read

Aortic root in competitive sports: eyes on the older athlete.

Heart 2019 Apr 10. Epub 2019 Apr 10.

Departments of Cardiology and Radiology, Amsterdam University Medical Centre, location AMC, Amsterdam, NH, The Netherlands.

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http://dx.doi.org/10.1136/heartjnl-2019-314759DOI Listing

Mechanical dispersion and arrhythmic mitral valve prolapse: substrate and trigger in electrical instability.

Heart 2019 Apr 10. Epub 2019 Apr 10.

Cardiovascular Pathology Unit, Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padua Medical School, Padova, Italy.

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http://dx.doi.org/10.1136/heartjnl-2019-314788DOI Listing
April 2019
1 Read

Direct oral anticoagulation and mortality in moderate to high-risk atrial fibrillation.

Heart 2019 Apr 10. Epub 2019 Apr 10.

Hematology Institute and BloodBank, Meir Medical Center, Kfar Saba, Israel.

Objective: Although direct oral anticoagulants (DOAC) are the recommended antithrombotic therapy for patients with non-valvular atrial fibrillation (NVAF), anticoagulation in patients with NVAF is still inadequate. The effect of withholding DOAC therapy on patient survival is unknown. Therefore, our objective was to compare all-cause mortality rates between DOAC-treated patients with NVAF and similar patients receiving no anticoagulation. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314476DOI Listing
April 2019
1 Read

Connection between the heart and the gut.

Heart 2019 Apr 8. Epub 2019 Apr 8.

Clinical Research and Imaging Centre, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1136/heartjnl-2019-314832DOI Listing
April 2019
1 Read

Prognosis and NT-proBNP in heart failure patients with preserved versus reduced ejection fraction.

Heart 2019 Apr 8. Epub 2019 Apr 8.

Heart Centre, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amasterdam, The Netherlands.

Background: We assessed the prognostic significance of absolute and percentage change in N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in patients hospitalised for acute decompensated heart failure with preservedejection fraction (HFpEF) versus heart failure with reduced ejection fraction (HFrEF).

Methods: Patients with left ventricular ejection fraction ≥50% were categorised as HFpEF (n=283), while those with <40% as were categorised as HFrEF (n=776). Prognostic values of absolute and percentage change in NT-proBNP levels for 6 months all-cause mortality after discharge were assessed separately in patients with HFpEF and HFrEF by multivariable adjusted Cox regression analysis. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314173DOI Listing
April 2019
2 Reads

British Cardiovascular Intervention Society database: insights into interventional cardiology in the United Kingdom.

Authors:
Peter Ludman

Heart 2019 Apr 8. Epub 2019 Apr 8.

Cardiology Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.

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http://dx.doi.org/10.1136/heartjnl-2018-314533DOI Listing

Anticoagulation therapy in heart failure and sinus rhythm: a systematic review and meta-analysis.

Heart 2019 Apr 8. Epub 2019 Apr 8.

BHF Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.

Objective: Heart failure is a prothrombotic state, and it has been hypothesised that thrombosis and embolism cause non-fatal and fatal events in heart failure and reduced ejection fraction (HFrEF). We sought to determine the effect of anticoagulant therapy on clinical outcomes in patients with HFrEF who are in sinus rhythm.

Methods: We conducted an updated systematic review and meta-analysis to examine the effect of anticoagulation therapy in patients with HFrEF in sinus rhythm. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314381DOI Listing

Cardiovascular health and sleep disturbances in two population-based cohort studies.

Heart 2019 Apr 8. Epub 2019 Apr 8.

Universite Paris Descartes, Paris, France.

Objective: We aimed to investigate the association between cardiovascular health (CVH), as defined by the American Heart Association, and several sleep disturbances.

Methods: Two community-based cohorts, the Paris Prospective Study 3 (PPS3, France, n=6441) and the CoLaus study (Switzerland, n=2989) were analysed. CVH includes 7 metrics which all can be classified as poor, intermediate and ideal. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314485DOI Listing
April 2019
1 Read

Fifty-year-old man with inferior ST elevation.

Heart 2019 Apr 4. Epub 2019 Apr 4.

Basingstoke and North Hampshire Hospital, Basingstoke, UK.

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http://dx.doi.org/10.1136/heartjnl-2018-314616DOI Listing

Cardiac magnetic resonance in patients with elevated troponin and normal coronary angiography.

Heart 2019 Apr 4. Epub 2019 Apr 4.

Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA.

Background: Invasive angiography in the setting of cardiac troponin elevation may reveal non-obstructive coronary arteries leading to uncertainty in diagnosis. Cardiac MR (CMR) may aid in diagnosis, however, the spectrum of diagnostic findings in the patient presenting with symptoms of cardiac ischaemia, elevated cardiac biomarkers and a negative invasive coronary angiogram is yet to be completely described.

Methods: We queried the Mayo Clinic, Rochester inpatient record from 1 January 2000 to 31 December 2016 to identify patients who: (1) had an elevated troponin T during admission, (2) underwent coronary angiography within 30 days of troponin T elevation which was considered negative for obstructive coronary arterial disease and (3) underwent CMR within 30 days of troponin T elevation. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314631DOI Listing
April 2019
2 Reads

Cardiovascular CT: the role of cardiologists.

Heart 2019 Apr 4. Epub 2019 Apr 4.

Departments of Cardiology and Radiology, Royal Brompton and Harefield NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1136/heartjnl-2018-314557DOI Listing

Pericardial diseases in patients with hypothyroidism.

Heart 2019 Apr 4. Epub 2019 Apr 4.

Center for the Diagnosis and Treatment of Pericardial Diseases, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Hypothyroidism is a well-known cause of pericardial effusion (with an incidence of 3%-37%) and can cause cardiac tamponade in severe cases. In this review, we present the current knowledge on the epidemiology of hypothyroid-induced pericardial diseases, the mechanism through which low thyroid hormone levels affect the pericardium, the associated clinical manifestations, diagnostic tests and management options. Hypothyroidism causes pericardial effusion through increased permeability of the epicardial vessels and decreased lymphatic drainage of albumin, resulting in accumulation of fluid in the pericardial space. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314528DOI Listing
April 2019
4 Reads

Five-year costs from a randomised comparison of bilateral and single internal thoracic artery grafts.

Heart 2019 Apr 4. Epub 2019 Apr 4.

Nuffield Department of Surgical Sciences, John Radcliffe Hospital, Oxford, Oxfordshire, UK.

Background: The use of bilateral internal thoracic arteries (BITA) for coronary artery bypass grafting (CABG) may improve survival compared with CABG using single internal thoracic arteries (SITA). We assessed the long-term costs of BITA compared with SITA.

Methods: Between June 2004 and December 2007, 3102 patients from 28 hospitals in seven countries were randomised to CABG surgery using BITA (n=1548) or SITA (n=1554). Read More

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http://dx.doi.org/10.1136/heartjnl-2018-313932DOI Listing
April 2019
1 Read

Comparative trends in coronary heart disease subgroup hospitalisation rates in England and Australia.

Heart 2019 Apr 4. Epub 2019 Apr 4.

Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Background: Population-based coronary heart disease (CHD) studies have focused on myocardial infarction (MI) with limited data on trends across the spectrum of CHD. We investigated trends in hospitalisation rates for acute and chronic CHD subgroups in England and Australia from 1996 to 2013.

Methods: CHD hospitalisations for individuals aged 35-84 years were identified from electronic hospital data from 1996 to 2013 for England and Australia and from the Oxford Region and Western Australia. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314512DOI Listing
April 2019
1 Read

Risk factors for longitudinal changes in left ventricular diastolic function among women and men.

Heart 2019 Apr 1. Epub 2019 Apr 1.

Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.

Objective: To evaluate changes in left ventricular diastolic function (LVDF) parameters and their associated risk factors over a period of 11 years among community-dwelling women and men.

Methods: Echocardiography was performed three times among 870 women and 630 men (age 67±3 years) from the prospective population-based Rotterdam Study during a period of 11-year follow-up. Changes in six continuous LVDF parameters were correlated with cardiovascular risk factors using a linear-mixed effect model (LMM). Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314487DOI Listing
April 2019
1 Read

Metformin prescription and aortic aneurysm: systematic review and meta-analysis.

Heart 2019 Apr 1. Epub 2019 Apr 1.

School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objective: To assess the association of metformin prescription with the risk of aortic aneurysm, aortic aneurysm events and the enlargement of abdominal aortic aneurysm (AAA).

Design: Systematic review and meta-analysis.

Methods: We searched PubMed, Embase and Scopus for epidemiological studies up to November 2018. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314639DOI Listing
April 2019
2 Reads

Increasing trends in hospitalisations due to atrial fibrillation in Australia from 1993 to 2013.

Heart 2019 Apr 1. Epub 2019 Apr 1.

Centre for Heart Rhythm Disorders, University of Adelaide and Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Objective: The aim of this study is to characterise hospitalisations due to atrial fibrillation (AF) compared with two other common cardiovascular conditions, myocardial infarction (MI) and heart failure (HF), in addition to the associated economic burden of these hospitalisations and contribution of AF-related procedures.

Methods: The primary outcome measure was the rate of increase of AF, MI and HF hospitalisations from 1993 to 2013. The rate of increase of AF-related procedures including cardioversion and ablation were also collected, in addition to direct costs associated with hospitalisations for each of these three conditions. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314471DOI Listing
April 2019
1 Read

Effect of communicating phenotypic and genetic risk of coronary heart disease alongside web-based lifestyle advice: the INFORM Randomised Controlled Trial.

Heart 2019 Mar 30. Epub 2019 Mar 30.

MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.

Objective: To determine whether provision of web-based lifestyle advice and coronary heart disease risk information either based on phenotypic characteristics or phenotypic plus genetic characteristics affects changes in objectively measured health behaviours.

Methods: A parallel-group, open randomised trial including 956 male and female blood donors with no history of cardiovascular disease (mean [SD] age=56.7 [8. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314211DOI Listing
March 2019
2 Reads

Long-term mortality and cardiovascular burden for adult survivors of coarctation of the aorta.

Heart 2019 Mar 28. Epub 2019 Mar 28.

Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital, London, UK.

Objective: To examine the contemporary long-term outcome after coarctation repair.

Methods: This is a retrospective cohort study of 834 patients aged ≥16 years who underwent coarctation repair under single-centre follow-up. Repair was performed at a median age of 3 years (lower-upper quartile: 1 month to 15 years) by surgery in 83% (690/834) and angioplasty/stenting in 17% (144/834). Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314257DOI Listing
March 2019
1 Read

Intracardiac mass in a 66-year-old woman.

Heart 2019 Mar 28. Epub 2019 Mar 28.

Department of Cardiovascular Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

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http://dx.doi.org/10.1136/heartjnl-2018-314600DOI Listing
March 2019
5.595 Impact Factor

Fifty-nine-year-old man with acute breathlessness and intermittent chest pain.

Heart 2019 Mar 28. Epub 2019 Mar 28.

Barts Heart Centre, Barts Health NHS Trust, London, UK.

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http://dx.doi.org/10.1136/heartjnl-2018-314642DOI Listing

Prevalence of heart failure and other risk factors among first-degree relatives of women with peripartum cardiomyopathy.

Heart 2019 Mar 25. Epub 2019 Mar 25.

Department of Obstetrics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Objectives: Peripartum cardiomyopathy (PPCM) is a rare disease carrying a risk of death and chronic heart failure.It is unknown if women with PPCM have a family history of heart failure. We investigated the prevalence of heart failure and hypertension in first-degree relatives to women with PPCM. Read More

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http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2018-314552
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http://dx.doi.org/10.1136/heartjnl-2018-314552DOI Listing
March 2019
7 Reads

Prevalence and progression of aortic root dilatation in highly trained young athletes.

Heart 2019 Mar 25. Epub 2019 Mar 25.

Cardiology Clinical and Academic Group, St. George's, University of London, London. SW17 0RE, UK.

Objectives: Aortic root dilatation is reported in young athletes; however, it is unclear whether such remodelling is physiological or, whether it represents a potential aortopathy. This observational study investigated the prevalence and progression of aortic root dilatation in young athletes competing at regional or national level.

Methods: Between 2003 and 2015, 3781 athletes aged 19±5. Read More

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http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2018-314288
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http://dx.doi.org/10.1136/heartjnl-2018-314288DOI Listing
March 2019
10 Reads
5.595 Impact Factor

Peripartum cardiomyopathy: a family affair?

Heart 2019 Mar 25. Epub 2019 Mar 25.

Innovation Hub, University of Montreal Hospital Research Centre, Quebec, Canada.

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http://dx.doi.org/10.1136/heartjnl-2019-314845DOI Listing
March 2019
1 Read

Atrial fibrillation: what do we know about screening and what do we not know about treatment?

Heart 2019 Mar 21. Epub 2019 Mar 21.

Department of Medicine, Division of Cardiology, Duke University Medical Center, Duke Clinical Research Institute, Durham, North Carolina, USA.

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http://dx.doi.org/10.1136/heartjnl-2018-314518DOI Listing
March 2019
1 Read

External continuous ECG versus loop recording for atrial fibrillation detection in patients who had a stroke.

Heart 2019 Mar 21. Epub 2019 Mar 21.

Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.

Background: Detection of atrial fibrillation (AF) in patients who had ischaemic stroke and transient ischaemic attack (IS/TIA) is recommended. We aimed to compare external loop recording (ELR) against simultaneous continuous ECG recording for AF detection in patients who had acute IS/TIA and determine sensitivity, specificity and positive predictive value of AF detection using ELR. We hypothesised ELR to detect 15% fewer patients with AF than continuous ECG recording. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314186DOI Listing

Implications of the local haemodynamic forces on the phenotype of coronary plaques.

Heart 2019 Mar 15. Epub 2019 Mar 15.

Department of Cardiology, Bern University Hospital, Bern, Switzerland.

Aim: To examine the effect of endothelial shear stress (ESS) on the dynamic changes in plaque phenotype.

Methods: Patients with myocardial infarction that had intravascular ultrasound-virtual histology (IVUS-VH) and optical coherence tomography (OCT) at baseline and 13-month follow-up were studied. The IVUS-VH data were used to reconstruct the nonculprit vessels, and in the obtained models the ESS was estimated in 3 mm segments. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314086DOI Listing
March 2019
2 Reads

Cardiovascular risk in 159 934 frequent blood donors while addressing the healthy donor effect.

Heart 2019 Mar 14. Epub 2019 Mar 14.

Department of Donor Medicine Research - Donor Studies, Sanquin Research, Amsterdam, The Netherlands.

Objective: To investigate whether regular blood donation decreases cardiovascular risk.

Methods: All 159 934 Dutch whole-blood donors with an active donation career of at least 10 years were categorised into sex-specific donation tertiles based on the number of donations during this 10-year qualification period. Cardiovascular endpoints were based on hospital discharge diagnoses and death certificates from Dutch Hospital Data and Statistics Netherlands and occurring after the 10-year qualification period. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314138DOI Listing

Antithrombotic therapy in patients undergoing transcatheter aortic valve implantation.

Heart 2019 Mar 13. Epub 2019 Mar 13.

Department of Cardiology, St Antonius Hospital, Nieuwegein, The Netherlands.

This review provides a comprehensive overview of the available data on antithrombotic therapy after transcatheter aortic valve implantation (TAVI). In the absence of large randomised clinical trials, clinical practice is leaning towards evidence reported in other populations. Due to the greater risk of major bleeding associated with oral anticoagulation using a vitamin-K antagonist (VKA), antiplatelet therapy (APT) may be considered as the first-line treatment of patients undergoing TAVI. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314313DOI Listing
March 2019
1 Read

sST2: a new kid on the block for patients with ACHD.

Authors:
Oktay Tutarel

Heart 2019 Mar 12. Epub 2019 Mar 12.

Department of Paediatric Cardiology and Congenital Heart Disease, German Heart Centre Munich, Munich, Germany.

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http://dx.doi.org/10.1136/heartjnl-2019-314699DOI Listing

Aortic valve area: too important for splendid isolation.

Authors:
Jan Minners

Heart 2019 Mar 12. Epub 2019 Mar 12.

Department of Cardiology, University Heart Center Freiburg, Bad Krozingen, Germany.

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http://dx.doi.org/10.1136/heartjnl-2019-314734DOI Listing
March 2019
3 Reads

Transcatheter aortic valve implantation in low-risk patients: is it too early?

Authors:
Miguel Sousa Uva

Heart 2019 Mar;105(Suppl 2):s51-s56

Department of Cardiac Surgery, Hospital Santa Cruz, Lisbon, Portugal.

The median age of patients treated by transcatheter aortic valve implantation (TAVI) is falling across Europe, and low-risk patients with severe aortic stenosis (AS) represent 80% of patients with severe AS undergoing surgical aortic valve replacement (SAVR). There are few data for TAVI in low-risk patients, but there are four ongoing randomised trials of SAVR versus TAVI. The key issues relate to pacemaker implantation rates and the associated potential longer term deleterious effects, and the need to minimise vascular complications and paravalvular leak. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314248DOI Listing
March 2019
1 Read

Transcatheter versus surgical intervention: lessons from trials of coronary revascularisation.

Heart 2019 Mar;105(Suppl 2):s44-s49

Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.

In this paper, a cardiac surgeon and an interventional cardiologist draw lessons from the trials of percutaneous coronary intervention/coronary artery bypass graft surgery (PCI/CABG) for the transcatheter aortic valve implantation/surgical aortic valve replacement (TAVI/SAVR) era. Both PCI and CABG are effective treatments, but do the trials ask the right questions? They dwell on the 'either/or' decision for selected patients suitable for both treatments, but provide little guidance for the majority of 'real world' patients with comorbidities precluding CABG, or complex coronary heart disease precluding PCI. The control group must be meaningful and relevant. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-313518DOI Listing
March 2019
1 Read

Transcatheter aortic valve replacement in failed surgical valves.

Heart 2019 Mar;105(Suppl 2):s38-s43

Division of Cardiology, University of Washington, Seattle, Washington, United States of America.

Aortic valve-in-valve is a less invasive alternative to surgical redo in the treatment of failed bioprosthetic valves. While only inoperable patients underwent the procedure before, operators currently offer it to those at lower risk and worldwide experience is in the thousands. Early mortality has diminished in recent analyses and improvements in symptoms and quality of life have been documented. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-313517DOI Listing
March 2019
1 Read

Results of mechanical versus tissue AVR: caution in young patients with tissue AVR.

Heart 2019 Mar;105(Suppl 2):s34-s37

The first aortic valve prosthesis, implanted more than 50 years ago, was a mechanical prosthesis (ball-and-cage design). Over the ensuing decades, tissue prostheses and new mechanical designs were introduced to mitigate the need for anticoagulation with its associated side effects. Tissue and mechanical heart valve prostheses were compared in two head-to-head randomised control trials. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-313516DOI Listing
March 2019
1 Read

Patient-prosthesis mismatch following aortic valve replacement.

Heart 2019 Mar;105(Suppl 2):s28-s33

Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA.

Patient-prosthesis mismatch (PPM) occurs when an implanted prosthetic valve is too small for the patient; severe PPM is defined as an indexed effective orifice area (iEOA) <0.65 cm/m following aortic valve replacement (AVR). This review examines articles from the past 10 years addressing the prevalence, outcomes and options for prevention and treatment of PPM after AVR. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-313515DOI Listing
March 2019
1 Read

Patient-specific computer simulation for transcatheter cardiac interventions: what a clinician needs to know.

Heart 2019 Mar;105(Suppl 2):s21-s27

Department of Cardiology, Guy's and St Thomas' NHS Foundation Trust London, London, UK.

Patient-specific computer simulation consists of the assessment of the interaction of the device with the host based on the integration of the detailed geometric and biomechanical properties of the device and host. Hence, it allows the prediction of valve performance (efficacy) and complications (safety) and may consequently help the physician to select the valve/device that best fits the individual patient, thereby improving outcome. There is currently little awareness and information in clinical medicine on patient-specific computer simulation. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-313514DOI Listing
March 2019
1 Read

Sutureless aortic valve prostheses.

Heart 2019 Mar;105(Suppl 2):s16-s20

Department of Cardiothoracic Surgery, St George's Hospital, London, UK.

Conventional surgical aortic valve replacement (AVR) is the 'gold standard' for treatment of severe or symptomatic aortic valve stenosis. The increasing age of patients and increasing comorbidities has led to the development of procedures to minimise operative time and reduce risks of surgery. One method of reducing operative times is the use of sutureless aortic valves (SU-AVR). Read More

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http://dx.doi.org/10.1136/heartjnl-2018-313513DOI Listing

Minimally invasive surgical aortic valve replacement.

Heart 2019 Mar;105(Suppl 2):s10-s15

Department of Cardiothoracic Surgery, South Tees NHS Foundation Trust, North Yorkshire, UK.

Minimally invasive aortic valve replacement (MIAVR) is defined as a surgical aortic valve replacement which involves smaller chest incisions as opposed to full sternotomy. It is performed using cardiopulmonary bypass with cardiac arrest. It benefits from potential advantages of a less invasive procedure. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-313512DOI Listing
March 2019
1 Read

Clinical trials of transcatheter aortic valve replacement.

Heart 2019 Mar;105(Suppl 2):s6-s9

Baylor Scott and White Heart Hospital Plano, Plano, Texas, USA.

Transcatheter aortic valve replacement(TAVR) has emerged as an effective treatment option in patients with severe aortic stenosis, in large part due to a robust evidence base generated by a series of randomised controlled trials (RCTs). During the past decade more than 15 000 patients have been randomised worldwide in nine clinical trials, mostly for regulatory approval in the USA, making it one of the most carefully scrutinised medical devices at the time of introduction into clinical practice. Initial trials were performed in inoperable or extreme risk patients compared to medical therapy and demonstrated superiority. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-313511DOI Listing
March 2019
1 Read

UK TAVI registry.

Authors:
Peter F Ludman

Heart 2019 Mar;105(Suppl 2):s2-s5

Cardiology Department, Queen Elizabeth Hospital, Birmingham B15 2TH, UK.

The UK Transcatheter Aortic Valve Implantation (TAVI) registry has collected data about every TAVI procedure performed in the UK. The latest data are from 2016 when 3250 procedures (49.5 pmp) were performed. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-313510DOI Listing
March 2019
2 Reads

Foreward to TAVI/SAVR supplement.

Heart 2019 Mar;105(Suppl 2):s1

Sheffield Teaching Hospitals NHS Trust & University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1136/heartjnl-2018-313509DOI Listing
March 2019
1 Read

Proprotein convertase subtilisin/kexin 9 inhibitors in reducing cardiovascular outcomes: a systematic review and meta-analysis.

Heart 2019 Mar 6. Epub 2019 Mar 6.

Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.

Background: To evaluate the effects of proprotein convertase subtilisin/kexin 9 (PCSK9) inhibitors on major adverse cardiovascular events (MACE).

Methods: Our systematic review included randomised controlled trials if they studied PCSK9 inhibitors in patients for primary and/or secondary prevention of cardiovascular diseases or with hypercholesterolaemia/hyperlipidaemia. Dichotomous variables from individual studies were pooled by relative risks (RR) and their 95% CIs using the random-effect model. Read More

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http://dx.doi.org/10.1136/heartjnl-2019-314763DOI Listing
March 2019
1 Read
5.595 Impact Factor