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    Cervical plexus anesthesia versus general anesthesia for anterior cervical discectomy and fusion surgery: A randomized clinical trial.
    Medicine (Baltimore) 2017 Feb;96(7):e6119
    aDepartment of Spine Surgery bFinancial Statistics Office, The Third Hospital of HeBei Medical University cThe Orthopaedic Department From First Hospital of Shijiazhuang, Shijiazhuang, China.
    Both general anesthesia (GA) and cervical plexus anesthesia (CPA) can be used for anterior cervical discectomy and fusion (ACDF) surgery. The aim of this study was to evaluate the influence of anesthetic techniques on perioperative mortality and morbidity in patients undergoing cervical surgery.From January 2008 to December 2015, 356 patients who underwent 1-level ACDF for cervical spinal myelopathy were prospectively reviewed. Read More

    Obstetric and perinatal outcome in anti-Ro/SSA-positive pregnant women: a prospective cohort study.
    Immunol Res 2017 Jan 30. Epub 2017 Jan 30.
    Obstetric and Gynecology Department, High Risk Pregnancy Unit, Autoimmune diseases and pregnancy clinic, University Hospital La Paz, Paseo de la Castella 261, 28046, Madrid, Spain.
    Anti-Ro/SS-A is one specific type of antinuclear antibodies. They are in the majority of cases associated with primary Sjögren syndrome (SS) but also in Systemic Lupus Erythematosus (SLE), rheumatoid arthritis (RA), and in healthy people. During pregnancy, they are mainly associated to congenital heart block (CHB) and neonatal lupus (NL). Read More

    Ro52 autoantibodies arise from self-reactive progenitors in a mother of a child with neonatal lupus.
    J Autoimmun 2017 Jan 21. Epub 2017 Jan 21.
    Dept. Medicine, Division of Rheumatology, New York University School of Medicine, New York, USA.
    The detection of cardiac conduction defects in an 18-24 week old foetus in the absence of structural abnormalities predicts with near certainty the presence of autoantibodies against 60kD and 52kD SSA/Ro in the mother regardless of her health status. Previous studies have emphasized these autoantibodies as key mediators of tissue injury. The aim of this study was to focus on the anti-Ro52 response to determine whether these autoantibodies originate from progenitors that are inherently self-reactive or from B-cells that acquire self-reactivity during an immune response. Read More

    Electrocardiographic assessments and cardiac events after fingolimod first dose - a comprehensive monitoring study.
    BMC Neurol 2017 Jan 18;17(1):11. Epub 2017 Jan 18.
    Charité Universitaetsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, Berlin, 13353, Germany.
    Background: First dose observation for cardiac effects is required for fingolimod, but recommendations on the extent vary. This study aims to assess cardiac safety of fingolimod first dose. Individual bradyarrhythmic episodes were evaluated to assess the relevance of continuous electrocardiogram (ECG) monitoring. Read More

    Development and impact of arrhythmias after the Norwood procedure: A report from the Pediatric Heart Network.
    J Thorac Cardiovasc Surg 2017 Mar 16;153(3):638-645.e2. Epub 2016 Nov 16.
    Division of Cardiovascular Sciences, The National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
    Objectives: The study objective was to determine the predictors of new-onset arrhythmia among infants with single-ventricle anomalies during the post-Norwood hospitalization and the association of those arrhythmias with postoperative outcomes (ventilator time and length of stay) and interstage mortality.

    Methods: After excluding patients with preoperative arrhythmias, we used data from the Pediatric Heart Network Single Ventricle Reconstruction Trial to identify risk factors for tachyarrhythmias (atrial fibrillation, atrial flutter, supraventricular tachycardia, junctional ectopic tachycardia, and ventricular tachycardia) and atrioventricular block (second or third degree) among 544 eligible patients. We then determined the association of arrhythmia with outcomes during the post-Norwood hospitalization and interstage period, adjusting for identified risk factors and previously published factors. Read More

    Safety of regadenoson stress testing in patients with pulmonary hypertension.
    J Nucl Cardiol 2016 Nov 28. Epub 2016 Nov 28.
    Division of Cardiovascular Medicine, Department of Internal Medicine and Frankel Cardiovascular Center, University of Michigan, 2nd Floor CVC / SPC 5853, 1500 E. Medical Center Dr.,, Ann Arbor, MI, 48109-5853, USA.
    Objectives: We sought to determine the safety of regadenoson stress testing in patients with PH.

    Background: PH is increasingly recognized at more advanced ages. As many as one-third of patients with PH have coronary artery disease. Read More

    Lyme Carditis: An Interesting Trip to Third-Degree Heart Block and Back.
    Case Rep Cardiol 2016 6;2016:5454160. Epub 2016 Nov 6.
    Department of Medicine, Memorial Hospital of Rhode Island, Alpert Medical School, Brown University, Pawtucket, RI, USA.
    Carditis is an uncommon presentation of the early disseminated phase of Lyme disease. We present the case of a young female who presented with erythema migrans and was found to have first-degree heart block which progressed to complete heart block within hours. After receiving ceftriaxone, there was complete resolution of the heart block in sequential fashion. Read More

    Complete Heart Block in Association with Dengue Hemorrhagic Fever.
    Korean Circ J 2016 Nov 13;46(6):866-869. Epub 2016 Oct 13.
    Department of Medicine, Johnson City Medical Center, Quillen College of Medicine, Johnson City, TN, USA.
    Dengue virus infection affects the heart structurally and functionally. Clinical manifestations of cardiac complications secondary to dengue virus infection vary from self-limiting arrhythmias to severe myocardial infarction, leading to hypotension, pulmonary edema, and cardiogenic shock. However, we report a case of dengue hemorrhagic fever (DHF) complicated by a complete heart block. Read More

    Syncope in patients paced for atrioventricular block.
    Europace 2016 Nov 6;18(11):1735-1739. Epub 2016 Feb 6.
    Arrhythmologic Centre, Department of Cardiology, Ospedali del Tigullio, Lavagna 16033, Italy
    Aims: Although syncope is the main reason for cardiac pacing in ∼40% of patients affected by atrioventricular block (AVB), very few data are available on the benefit of cardiac pacing in preventing syncopal recurrences.

    Methods And Results: We retrospectively evaluated 229 consecutive patients (124 males, age 80 ± 10 years) who had received a permanent pacemaker from January 2009 to December 2013 for AVB and syncope (94 patients, 41%) or AVB without syncope (135 patients, 59%). In patients with AVB and syncope, a third-degree or Mobitz II second-degree AVB had been documented in 73 and was only suspected in another 21, all of whom had bundle branch block. Read More

    Isolated congenital complete heart block in a five-year-old seronegative girl born to a woman seropositive for human immunodeficiency virus: a case report.
    J Med Case Rep 2016 Oct 19;10(1):288. Epub 2016 Oct 19.
    Department of Cardiovascular Medicine, The Jakaya Kikwete Cardiac Institute, P.O Box 65141, Dar es Salaam, Tanzania.
    Background: Congenital complete heart block is a life-threatening condition which is highly associated with autoimmune and connective tissue disorders. Presence of maternal autoantibodies for associated conditions increases the risk of delivering a child with congenital complete heart block, however, less than a half of all women with such antibodies are symptomatic even after delivery. Mortality rate is highest during the neonatal period (45 %) and about two-thirds of all cases will require permanent pacing at some point in their lives. Read More

    Paroxysmal atrioventricular block after heart transplantation in children: an early sign of rejection?
    Pediatr Transplant 2016 Dec 14;20(8):1164-1167. Epub 2016 Oct 14.
    Pediatric Cardiology and Cardiac Arrhythmias-Syncope Unit, Department of Pediatric Cardiology and Cardiac Surgery, Bambino Gesù Children's Hospital and Research Institute, Rome, Italy.
    In OHT recipients, pathologic evaluation of the heart during acute rejection can show involvement of both the conduction system and the myocardium. We here describe the cases of a 9-year-old male with DCM and a 13-year-old female with RCM, who developed third-degree PAVB associated with acute rejection 36 months and 24 months after OHT, respectively. We conclude that PAVB could be considered an early sign of acute rejection after OHT in children who exhibit post-transplantation presyncope or syncope. Read More

    Life-threatening cardiac episode in a Polish patient carrying contiguous gene microdeletion of the TBX5 and the TBX3 genes.
    Springerplus 2016 21;5(1):1638. Epub 2016 Sep 21.
    Department of Medical Genetics, Poznan University of Medical Sciences, Fredry 10, 61-701 Poznan, Poland ; NZOZ Center for Medical Genetics, GENESIS ul. Grudzieniec 4, 60-601 Poznan, Poland.
    Holt-Oram syndrome (HOS) features radial ray hypoplasia, heart defect and cardiac conduction impairment. Ulnar-mammary syndrome (UMS) characterizes congenital defects of the ulnar side of the upper limbs, underdevelopment of apocrine glands including hypoplasia and the dysfunction of mammary glands, hypogonadism and obesity. Inheritance of both conditions is autosomal dominant, mutations or deletions are found in the TBX5 and TBX3 gene, respectively. Read More

    Traumatic Gerbode ventricular septal defect and third-degree heart block.
    Cardiol Young 2016 Sep 19:1-3. Epub 2016 Sep 19.
    1Department of Pediatrics,Duke University,Durham,North Carolina,United States of America.
    We present an interesting and rare case of traumatic Gerbode ventricular septal defect and complete heart block. The multimodality images illustrate the diagnosis well. This case is an excellent demonstration of the diagnostic utility of multimodality imaging. Read More

    Safety and Tolerability of Neladenoson Bialanate, a Novel Oral Partial Adenosine A1 Receptor Agonist, in Patients With Chronic Heart Failure.
    J Clin Pharmacol 2016 Sep 14. Epub 2016 Sep 14.
    Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
    We studied safety and tolerability of neladenoson bialanate, a novel oral selective partial adenosine A1 receptor agonist that maintains the cardioprotective effects of adenosine without the undesired side effects of a full agonist, in 2 pilot studies in patients with heart failure with reduced ejection fraction (HFrEF). The β-blocker interaction study was a single-blind, placebo-controlled study on the effects of a 30-mg single dose of neladenoson bialanate on atrioventricular (AV) conduction in 11 patients with HFrEF treated with β-blockers. The PARSiFAL pilot study was a double-blind, placebo-controlled study on the effects of a 7-day treatment with 10 or 20 mg neladenoson bialanate or placebo in 31 patients with HFrEF on β-blocker therapy. Read More

    Complete heart block in pregnancy: case report, analysis, and review of anesthetic management.
    J Clin Anesth 2016 Sep 27;33:58-61. Epub 2016 Apr 27.
    Department of Anesthesiology, University of Miami Miller School of Medicine, C-300, 1611 NW 12 Ave, Miami, FL 33136 USA.
    Maternal complete heart block can pose significant challenges for the anesthesiologist in the antepartum, peripartum, and postpartum periods. Some patients may present for the first time in the puerperium with dizziness, weakness, syncope, or congestive heart failure as a result of the additional hemodynamic burden that accompanies pregnancy. Although there is an increase in permanent pacemaker placement in young symptomatic patients before pregnancy, prophylactic placement of pacemakers in asymptomatic parturients is not always indicated. Read More

    Identification of discrete epitopes of Ro52p200 and association with fetal cardiac conduction system manifestations in a rodent model.
    Clin Exp Immunol 2016 Dec 13;186(3):284-291. Epub 2016 Sep 13.
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
    Congenital heart block (CHB) is a potentially lethal condition characterized by a third-degree atrioventricular block (AVB). Despite anti-Ro52 antibodies being detected in nearly 90% of mothers of affected children, CHB occurs in only 1-2% of anti-Ro/Sjögren's-syndrome-related antigen A (SSA) autoantibody-positive pregnancies. Maternal antibodies have been suggested to bind molecules crucial to fetal cardiac function; however, it remains unknown whether a single antibody profile associates with CHB or whether several specificities and cross-reactive targets exist. Read More

    Conduction disorders in bradyasystolic out-of-hospital cardiac arrest.
    Resuscitation 2016 Sep 12;106:113-9. Epub 2016 Jul 12.
    Academic Medical Center - Department of Cardiology, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
    Aims: Bradyasystolic heart rhythms are often recorded in out-of-hospital cardiac arrest (OHCA). Atrioventricular (AV) conduction disorders might lead to OHCA, but the prevalence of AV-conduction disorders and other bradyasystolic rhythms in OHCA is unknown. These patients might benefit from pre-hospital pacing. Read More

    Left Bundle Branch Block and Complete Heart Block Complicating Inferior Myocardial Infarction.
    Ann Noninvasive Electrocardiol 2017 Jan 13;22(1). Epub 2016 Jul 13.
    Department of Internal Medicine, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY, USA.
    Left bundle branch block following inferior myocardial infarction remains uncommon and scarcely reported in the literature. We describe a rare presentation of a 58-year-old male patient who developed left bundle branch block and third degree atrioventricular block after inferior myocardial infarction requiring permanent pacemaker placement. Pathophysiology, impact on mortality, and management options are discussed. Read More

    Long-Term Follow-Up of Children with Heart Block Born from Mothers with Systemic Lupus Erythematosus: A Retrospective Study from the Database Pediatric and Congenital Heart Disease in University Hospitals Leuven.
    Pacing Clin Electrophysiol 2016 Sep 2;39(9):935-43. Epub 2016 Aug 2.
    Congenital and Structural Cardiology, University Hospitals Leuven, Leuven, Belgium.
    Background: Children from mothers with systemic lupus erythematosus are frequently born with congenital heart block. This study aimed at evaluating long-term outcome because long-term data are scarce.

    Methods: In the database of pediatric and congenital heart disease (University Hospitals Leuven), 19 children from systemic lupus erythematosus mothers and who were born with or developed atrioventricular block were identified. Read More

    Heart block following stage 1 palliation of hypoplastic left heart syndrome.
    J Thorac Cardiovasc Surg 2016 Jul 11;152(1):189-94. Epub 2016 Apr 11.
    Department of Cardiology, Boston Children's Hospital and Harvard Medical School, Boston, Mass.
    Objectives: Publicly available data from the Pediatric Heart Network's Single Ventricle Reconstruction Trial was analyzed to determine the prevalence, timing, risk factors for, and impact of second- and third-degree heart block (HB) on outcomes in patients who underwent stage 1 palliation (S1P) for hypoplastic left heart syndrome (HLHS).

    Methods: The presence and date of onset of post-S1P HB occurring within the first year of life, potential risk factors for HB, and factors known to predict poor outcomes after S1P were extracted. Multivariable logistic and Cox regression analyses were performed to identify risk factors for HB and to determine the effect of HB on 3-year transplantation-free survival. Read More

    Electrophysiological Mechanisms of Bayés Syndrome: Insights from Clinical and Mouse Studies.
    Front Physiol 2016 31;7:188. Epub 2016 May 31.
    Department of Medicine and Therapeutics, The Chinese University of Hong KongHong Kong, China; Department of Epidemiology and Preventive Medicine, Monash UniversityMelbourne, VIC, Australia.
    Bayés syndrome is an under-recognized clinical condition characterized by inter-atrial block (IAB). This is defined electrocardiographically as P-wave duration > 120 ms and can be categorized into first, second and third degree IAB. It can be caused by inflammatory conditions such as systemic sclerosis and rheumatoid arthritis, abnormal protein deposition in cardiac amyloidosis, or neoplastic processes invading the inter-atrial conduction system, such as primary cardiac lymphoma. Read More

    Mobitz type I and II atrioventricular blocks during fingolimod therapy.
    Neurol Sci 2016 Sep 25;37(9):1557-9. Epub 2016 May 25.
    Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, Via Pansini, 5, 80131, Naples, Italy.
    We investigated patients who showed a second-degree atrioventricular block (S-AVB) after the first fingolimod administration. We observed six patients with S-AVB, three Mobitz type I, and three type II. Monitoring continued on the second day for all patients. Read More

    Incidence and characteristics of heart block after heart surgery in pediatric patients: A multicenter study.
    J Thorac Cardiovasc Surg 2016 Jul 7;152(1):197-202. Epub 2016 May 7.
    Division of Pediatric Cardiology, Department of Pediatrics, New York-Presbyterian/Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
    Background: Advanced second- or third-degree heart block has been reported with variable incidence after surgery for congenital heart disease in children. We report the incidence of heart block requiring a pacemaker and describe the risk factors for this complication in a large multicenter study.

    Methods: We performed a retrospective cohort study, using the Pediatric Health Information System database from 45 hospitals in the United States, for all children aged 18 years, discharged between January 1, 2004, and December 31, 2013, who underwent open surgery for congenital heart disease. Read More

    Continuous intraoperative monitoring of vagus and recurrent laryngeal nerve function in patients with advanced atrioventricular block.
    Langenbecks Arch Surg 2016 Jun 30;401(4):551-6. Epub 2016 Apr 30.
    Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube-Straße 40, 06120, Halle (Saale), Germany.
    Purpose: Intraoperative neuromonitoring of recurrent laryngeal nerve function after stimulation of the vagus nerve has been embraced as a risk minimization tool in thyroid surgery to prevent recurrent laryngeal nerve injury. Because this technology is increasingly used in an elderly and sicker population, the present study was conducted to determine the safety of this method in patients with second- or third-degree atrioventricular block.

    Methods: This study aimed at evaluating the feasibility and safety of continuous intraoperative neuromonitoring (CIONM) in patients with second- or third-degree atrioventricular block. Read More

    Repair of Partial Atrioventricular Septal Defect: Age and Outcomes.
    Ann Thorac Surg 2016 Jul 25;102(1):170-7. Epub 2016 Apr 25.
    Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
    Background: We evaluated the outcomes of patients undergoing surgical repair of partial atrioventricular septal defect (AVSD) and analyzed the effect of age on outcome.

    Methods: In this single-center retrospective study, we included all children who underwent repair of partial AVSD between 1990 and 2014. We divided the patients into 4 age quartiles (first quartile: 0-0. Read More

    Pacemaker lead perforation of the right ventricle associated with Moraxella phenylpyruvica infection in a dog.
    Aust Vet J 2016 Apr;94(4):101-6
    Advanced Vetcare, Level 1, 26 Robertson Street, Kensington, Victoria, 3031, Australia.
    Case Description: A 13-year-old neutered male Border Collie was presented with acute onset syncope, weakness and anorexia 10 months after transvenous pacemaker implantation. The patient was laterally recumbent, bradycardic (36 beats/min) and febrile (40.7°C) on presentation. Read More

    Failure of intravenous lipid emulsion in treatment of cardiotoxicity caused by mixed overdose including dihydropyridine calcium channel blockers.
    Vojnosanit Pregl 2016 Jan;73(1):88-91
    Introduction: Calcium channel blockers and beta-blockers are among the most frequently ingested cardiovascular drugs in self-poisoning causing significant mortality. Intravenous lipid emulsion (ILE) is reported as a potentially novel antidote for treatment of acute poisoning caused by some of these drugs.

    Case Report: We presented two cases of poisoning with these drugs. Read More

    Diagnostic and Prognostic Implications of Surface Recordings from Patients with Atrioventricular Block.
    Card Electrophysiol Clin 2016 Mar;8(1):25-35
    The atrioventricular (AV) bridge is vulnerable to many circumstances that depress conduction. Abnormal impulse transmission may be caused by drugs, autonomic effects, or destructive processes. Type 1 (Wenckebach) AV block is owing to depressed AV nodal conduction and is recognized by a prolonging PR interval ending in a "dropped beat. Read More

    Incidence and timing of potentially high-risk arrhythmias detected through long term continuous ambulatory electrocardiographic monitoring.
    BMC Cardiovasc Disord 2016 Feb 17;16:35. Epub 2016 Feb 17.
    Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
    Background: Ambulatory electrocardiographic (ECG) monitoring is the standard to screen for high-risk arrhythmias. We evaluated the clinical utility of a novel, leadless electrode, single-patient-use ECG monitor that stores up to 14 days of a continuous recording to measure the burden and timing of potentially high-risk arrhythmias.

    Methods: We examined data from 122,815 long term continuous ambulatory monitors (iRhythm ZIO® Service, San Francisco) prescribed from 2011 to 2013 and categorized potentially high-risk arrhythmias into two types: (1) ventricular arrhythmias including non-sustained and sustained ventricular tachycardia and (2) bradyarrhythmias including sinus pauses >3 s, atrial fibrillation pauses >5 s, and high-grade heart block (Mobitz Type II or third-degree heart block). Read More

    A Heart too Drunk to Drive; AV Block following Acute Alcohol Intoxication.
    Chin J Physiol 2016 Feb;59(1):1-8
    Department of Medical Physiology, Division of Heart & Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM Utrecht, The Netherlands.
    Acute excessive alcohol consumption is associated with heart rhythm disorders like atrial fibrillation but also premature ventricular contractions, collectively known as the "holiday heart syndrome". More rarely but clinically significant are reports of atrioventricular (AV) conduction disturbances in binge drinkers with no underlying heart disease or chronic alcohol consumption. To obtain better insights into common denominators and the potential underlying mechanisms we collected and compared individual case reports of AV block following acute alcohol intoxication in otherwise healthy people. Read More

    [Clinical analysis of tricuspid valve replacement].
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 2016 Jan;41(1):78-82
    Department of Cardiovascular Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
    Objective: To summarize the outcome of tricuspid valve replacement.

    Methods: A total of 28 patients (15 males and 13 females) underwent tricuspid valve replacement from March 2000 to February 2015 in the First Affiliated Hospital of Zhengzhou University were recruited. Among them, 16 patients were Ebstein's anomaly, 7 had rheumatic valve heart disease, 3 and 2 suffered from infective endocarditis and degenerative tricuspid lesions, respectively. Read More

    Congenital heart block related to maternal autoantibodies: descriptive analysis of a series of 18 cases from a single center.
    Clin Rheumatol 2016 Feb 20;35(2):351-6. Epub 2016 Jan 20.
    Department of Autoimmune Diseases, Hospital Clínic, Villarroel 170, 08036, Barcelona, Catalonia, Spain.
    The objective of this study was to describe the clinical and immunological characteristics of maternal autoimmune-mediated fetal congenital heart block (CHB) in a cohort of pregnant women from an autoimmune disease pregnancy clinic. This is a retrospective observational study of all women presenting with CHB in our autoimmune disease pregnancy clinic from January 1997 to December 2014. In addition, perinatal outcome is also described. Read More

    Subcutaneous nerve activity and mechanisms of sudden death in a rat model of chronic kidney disease.
    Heart Rhythm 2016 May 29;13(5):1105-12. Epub 2015 Dec 29.
    Krannert Institute of Cardiology, Division of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address:
    Background: The mechanisms of sudden death in chronic kidney disease (CKD) remain unclear.

    Objective: The purpose of this study was to test the hypotheses that subcutaneous nerve activity (SCNA) can be used to estimate sympathetic tone in ambulatory rats and that abrupt reduction of SCNA precedes the spontaneous arrhythmic death of Cy/+ rats.

    Methods: Radiotransmitters were implanted in ambulatory normal (N = 6) and Cy/+ (CKD; N = 6) rats to record electrocardiogram and SCNA. Read More

    Seven times replacement of permanent cardiac pacemaker in 33 years to maintain adequate heart rate: a case report.
    Ann Transl Med 2015 Dec;3(21):341
    Department of Cardiology, People's Hospital of Yuxi City, Yuxi 653100, China.
    Over the past few decades, recent developments in pacemaker technology from fixed-rate single-chamber pacemakers to dual chamber pacemakers with pacing algorithms have changed the therapeutic landscape resulting in better healthcare outcomes by improving rate response with minimal ventricular pacing. Here, we share our longest clinical experience with an elderly Chinese male patient who was diagnosed with third-degree atrioventricular (AV) block and was admitted in our hospital 33 years ago. An 85-year-old male patient from China was hospitalized due to dizziness and syncope, with an initial diagnosis revealing third-degree AV block with a heart rate of 35-40 beats per minute (bpm) along with Aase's syndrome and primary hypertension. Read More

    Feasibility and safety of adenosine cardiovascular magnetic resonance in patients with MR conditional pacemaker systems at 1.5 Tesla.
    J Cardiovasc Magn Reson 2015 Dec 22;17:112. Epub 2015 Dec 22.
    Deptartment of Cardiology, Katholisches Klinikum Essen, University of Witten/Herdecke, Hülsmannstraße 17, 45355, Essen, Germany.
    Background: Cardiovascular Magnetic Resonance (CMR) with adenosine stress is a valuable diagnostic tool in coronary artery disease (CAD). However, despite the development of MR conditional pacemakers CMR is not yet established in clinical routine for pacemaker patients with known or suspected CAD. A possible reason is that adenosine stress perfusion for ischemia detection in CMR has not been studied in patients with cardiac conduction disease requiring pacemaker therapy. Read More

    Myocardial infarction, symptomatic third degree atrioventricular block and pulmonary embolism caused by thalidomide: a case report.
    BMC Cardiovasc Disord 2015 Dec 18;15:173. Epub 2015 Dec 18.
    Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
    Background: Thalidomide has been reported to cause numerous thromboembolic events. Deep vein thrombosis and pulmonary embolism are more common. It can also cause bradycardia and even total atrioventricular block. Read More

    Long-term Intrinsic Rhythm Evaluation in Dogs with Atrioventricular Block.
    J Vet Intern Med 2016 Jan-Feb;30(1):58-62. Epub 2015 Nov 17.
    Clinica Veterinaria Malpensa, Samarate, Varese, Italy.
    Background: Atrioventricular block (AVB) is a conduction abnormality along the atrioventricular node that, depending on etiology, may lead to different outcomes.

    Objectives: To evaluate variations of intrinsic rhythm (IR) in dogs that underwent pacemaker implantation (PMI).

    Animals: Medical records of 92 dogs affected by 3rd degree atrioventricular block (3AVB), advanced 2nd degree AVB (2AVB), paroxysmal 3AVB, 2:1 2AVB, or 3AVB with atrial fibrillation (AF) were retrospectively reviewed. Read More

    Clinical observations of supraventricular arrhythmias in patients with brugada syndrome.
    Int J Clin Exp Med 2015 15;8(8):14520-6. Epub 2015 Aug 15.
    Department of Cardiology, Beijng Anzhen Hospital, Capital University of Medical Sciences Beijing, China.
    Objective: To study various types of supraventricular arrhythmias in patients with Brugada Syndrome.

    Methods: Forty six patients with ECG of spontaneous type Brugada and with ventricular and/or supraventricular tachyarrhythmia, without structural heart diseases which were excluded by echocardiography, underwent 24 h-Holter recording, electrophysiological study and/or radiofrequency ablation.

    Results: There were thirty-nine male and seven female (mean age 37. Read More

    Swallow syncope caused by third-degree atrioventricular block.
    BMJ Case Rep 2015 Oct 27;2015. Epub 2015 Oct 27.
    Department of Cardiology, Hvidovre Hospital, Hvidovre, Denmark.
    We report a case of a patient with more than 30 years of repeated syncopes, always following food intake. The patient was diagnosed with a swallow-related third-degree atrioventricular block and successfully treated with an artificial pacemaker. Read More

    Acquired tricuspid valve stenosis due to intentionally redundant transvenous lead placement for VDD pacing in two small dogs.
    J Vet Cardiol 2015 Dec 14;17(4):298-303. Epub 2015 Oct 14.
    Department of Medicine & Epidemiology, School of Veterinary Medicine, University of California, Davis, One Shields Ave, Davis, CA 95616, USA. Electronic address:
    Placement of an endocardial VDD pacing lead in small dogs (<12 kg) may necessitate a redundant lead remaining looped in the right atrium for appropriate sensing and pacing. This report documented acquired tricuspid valve stenosis in two small dogs between 8 months and 4 years after VDD pacemaker placement for third-degree atrioventricular block. Echocardiography and Doppler echocardiography identified elevated transtricuspid flow velocities, prolonged pressure half-times, decreased valve leaflet excursions, and tricuspid regurgitation in both cases. Read More

    Electrocardiographic and echocardiographic abnormalities in Chagas disease: findings in residents of rural Bolivian communities hyperendemic for Chagas disease.
    Glob Heart 2015 Sep;10(3):159-66
    Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, San Francisco, CA, USA.
    Background: Chagas disease is a neglected and preventable tropical disease that causes significant cardiac morbidity and mortality in Latin America.

    Objectives: This study sought to describe cardiac findings among inhabitants of rural communities of the Bolivian Chaco.

    Methods: The cardiac study drew participants from an epidemiologic study in 7 indigenous Guarani communities. Read More

    [Congenital Intermittent Third-degree Atrioventricular Block Associated with Retinoid Exposure in Pregnancy].
    Z Geburtshilfe Neonatol 2015 Dec 24;219(6):289-92. Epub 2015 Sep 24.
    Neonatologie und Päd. Intensivmedizin, Vestische Kinder- und Jugendklinik Datteln, Universität Witten/Herdecke, Datteln.
    Background: The retinoid acitretin, which has been approved as an effective therapy for severe keratinization disorders, is highly teratogenic, and exposure in the first trimester of pregnancy is associated with the risk of miscarriage and various malformations, including congenital heart defects. Cardiac conduction system disorders have not been described so far.

    Case Report: A 24-year-old woman was treated with acitretin for dyskeratosis follicularis until pregnancy was diagnosed at 12 weeks of gestation. Read More

    Comparison of (18)F-fluorodeoxyglucose positron emission tomography (FDG PET) and cardiac magnetic resonance (CMR) in corticosteroid-naive patients with conduction system disease due to cardiac sarcoidosis.
    Eur J Nucl Med Mol Imaging 2016 Feb 11;43(2):259-69. Epub 2015 Sep 11.
    Molecular Function and Imaging Program, National Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, Canada, K1Y 4W7.
    Purpose: Cardiac sarcoidosis (CS) is a cause of conduction system disease (CSD). (18)F-Fluorodeoxyglucose-positron emission tomography (FDG PET) and cardiac magnetic resonance (CMR) are used for detection of CS. The relative diagnostic value of these has not been well studied. Read More

    Cardiac resynchronization therapy in a young patient with Duchenne muscular dystrophy.
    Int Med Case Rep J 2015 21;8:173-5. Epub 2015 Aug 21.
    Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
    A 32-year-old man with Duchenne muscular dystrophy (DMD) was admitted to the hospital because of worsening dyspnea and general fatigue. He had received medication therapy for cardiomyopathy with heart failure and home mechanical ventilation for respiratory failure. An electrocardiogram on admission showed intermittent third-degree atrioventricular block. Read More

    Description of 214 cases of autoimmune congenital heart block: Results of the French neonatal lupus syndrome.
    Autoimmun Rev 2015 Dec 15;14(12):1154-60. Epub 2015 Aug 15.
    AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Paris, France; Université Paris Descartes-Sorbonne Paris Cité, Paris, France. Electronic address:
    Background: Cardiac neonatal lupus syndrome is due to anti-SSA or SSB antibodies and mainly includes congenital heart block (CHB) and dilated cardiomyopathy (DCM). Its optimal management is still debated. We report a large series of autoimmune high degree CHB. Read More

    Long-term cardiac prognosis and risk stratification in 260 adults presenting with mitochondrial diseases.
    Eur Heart J 2015 Nov 29;36(42):2886-93. Epub 2015 Jul 29.
    AP-HP, Pitié-Salpêtrière Hospital, Reference Center for Muscle Diseases Paris-Est, Myology Institute, 75651 Paris Cedex 13, France Pierre et Marie Curie-Paris 6 University, Myology Institute, Pitié-Salpêtrière Hospital, Paris 75013, France.
    Aims: The aim of this study is to assess the long-term cardiac prognosis of adults with mitochondrial diseases.

    Methods And Results: Between January 2000 and May 2014, we retrospectively included in this study 260 consecutive patients (60% women) ≥18 years (interquartile range 31-54), with genetically proven mitochondrial diseases, including 109 with mitochondrial DNA (mtDNA) single large-scale deletions, 64 with the m.3243A>G mutation in MT-TL1, 51 with other mtDNA point mutations, and 36 patients with nuclear gene mutations. Read More

    A Complicated Case of Triple Valve Infective Endocarditis in an IV Drug User with a Bicuspid Aortic Valve Requiring Three Separate Salvage Operations: A Case Report and Literature Review.
    Case Rep Cardiol 2015 3;2015:291079. Epub 2015 Jun 3.
    Danbury Hospital, Western Connecticut Health Network, 187 Willow Springs, New Milford, CT 06776, USA.
    Infective endocarditis (IE) is an infection of the endocardium that involves valves and adjacent mural endocardium or a septal defect. Local complications include severe valvular insufficiency, which may lead to intractable congestive heart failure and myocardial abscesses. If left untreated, IE is generally fatal. Read More

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