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    The Bridge Occlusion Balloon as a safety net in a high-risk transvenous lead extraction procedure.
    Interact Cardiovasc Thorac Surg 2017 Sep 8. Epub 2017 Sep 8.
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany.
    Injuries to the superior vena cava (SVC) during transvenous lead extraction (TLE) procedures are a rare but life-threatening complication. The Bridge Occlusion Balloon (BOB) is specifically designed for temporary SVC occlusion in TLE procedures. We report the first case of a 27-year-old man using the BOB as a safety net in a high-risk TLE procedure. Read More

    Relation of elevated serum uric acid levels to first-degree heart block and other cardiac conduction defects in hospitalized patients with type 2 diabetes.
    J Diabetes Complications 2017 Sep 20. Epub 2017 Sep 20.
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
    Aims: Several studies have reported that moderately elevated serum uric acid levels are associated with an increased risk of tachyarrhythmias (mainly atrial fibrillation) in patients with and without type 2 diabetes mellitus (T2DM). It is currently unknown whether an association also exists between elevated serum uric acid levels and cardiac conduction defects in patients with T2DM.

    Methods: We retrospectively analyzed a hospital-based sample of 967 patients with T2DM discharged from our Division of Endocrinology over the years 2007-2014. Read More

    Nonalcoholic fatty liver disease is associated with an increased risk of heart block in hospitalized patients with type 2 diabetes mellitus.
    PLoS One 2017 5;12(10):e0185459. Epub 2017 Oct 5.
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
    Recent studies suggested that nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiac tachyarrhythmias (mainly atrial fibrillation) in patients with and without type 2 diabetes mellitus. The aim of this study was to examine whether an association also exists between NAFLD and heart block. We have retrospectively evaluated a hospital-based cohort of 751 patients with type 2 diabetes discharged from our Division of Diabetes and Endocrinology during years 2007-2014. Read More

    A Thorough QT/QTc Study of Clobazam in Healthy Volunteers.
    Clin Ther 2017 Sep 25. Epub 2017 Sep 25.
    Ocera Therapeutics Inc, Vernon Hills, Illinois.
    Purpose: A thorough QT study was conducted to assess the proarrhythmic potential of clobazam and its active metabolite, N-desmethylclobazam (N-CLB).

    Methods: In this Phase I, single-site, randomized, double-blind, double-dummy, parallel-group study, healthy participants were randomized to 1 of 4 treatment groups: clobazam 40 mg/d (maximum therapeutic dosage), clobazam 160 mg/d (supratherapeutic dosage), placebo, or moxifloxacin 400 mg (active control).

    Findings: Of 280 enrolled participants (n = 70 per treatment arm), 250 (92%) completed the study; 194 were included in the pharmacokinetics population (clobazam 40 mg/d, n = 66; clobazam 160 mg/d, n = 62; and moxifloxacin, n = 66). Read More

    Genetic Mechanisms Contribute to the Development of Heart Failure in Patients with Atrioventricular Block and Right Ventricular Apical Pacing.
    Sci Rep 2017 Sep 6;7(1):10676. Epub 2017 Sep 6.
    State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, People's Republic of China.
    Right ventricular apical (RVA) pacing can lead to progressive left ventricular dysfunction and heart failure (HF), even in patients with normal cardiac structure and function. Our study conducted candidate gene screening and lentivirus transfected neonatal rat cardiomyocytes (NRCMs) to explore the genetic and pathogenic mechanisms of RVA pacing induced cardiomyopathy in third degree atrioventricular block (III AVB) patients. We followed 887 III AVB patients with baseline normal cardiac function and RVA pacing. Read More

    Transapical Transcatheter Aortic Valve Implantation Using a New TAVI System for High-Risk Patients with Severe Aortic Stenosis.
    Heart Lung Circ 2017 Aug 8. Epub 2017 Aug 8.
    Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China. Electronic address:
    Background: To evaluate the safety and efficacy of transcatheter aortic valve implantation (TAVI) for high-risk patients with aortic stenosis using the J-Valve system.

    Methods: 30 high-risk patients with severe AS underwent TAVI procedure were enrolled with mean age 74.5±4. Read More

    Conduction recovery and avoidance of permanent pacing after transcatheter aortic valve implantation.
    J Cardiol 2017 Aug 14. Epub 2017 Aug 14.
    Heart Center Brandenburg in Bernau, Medical School Brandenburg, Bernau, Germany. Electronic address:
    Background: Transcatheter aortic valve implantation (TAVI) is an established treatment option for patients with severe aortic stenosis and high surgical risk. Currently, various prosthesis types are available. Atrioventricular block (AVB) requiring pacemaker (PM) implantation is a typical complication after TAVI. Read More

    [Clinical analysis of pacing therapy and treatment of complications during follow-up in children].
    Zhonghua Er Ke Za Zhi 2017 Jul;55(7):514-518
    Department of Pediatric Cardiology, Shanghai Children's Medical Center, Shanghai Jiao Tong University, School of Medicine, Shanghai 200127, China.
    Objective: To analyze characteristics of permanent pacemaker implantation in children as well as treatment and prognosis of complications. Method: Clinical data of children who underwent endocardial or epicardial permanent pacemaker implantation between April 2000 and June 2016 in Shanghai Xinhua Hospital and Shanghai Children's Medical Center were analyzed retrospectively. These patients were discharged 5 days after implantation. Read More

    Conduction disturbance after isolated surgical aortic valve replacement in degenerative aortic stenosis.
    J Thorac Cardiovasc Surg 2017 Nov 15;154(5):1556-1565.e1. Epub 2017 Jun 15.
    Department of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
    Objective: Conduction disturbances are common in patients with aortic stenosis. We investigated the incidence, reversibility, and prognosis of conduction disorders requiring permanent pacemaker implantation in patients with degenerative aortic stenosis after isolated aortic valve replacement.

    Methods: This was a retrospective study conducted at a tertiary care center. Read More

    [Sudden cardiac death due to sarcoidosis. Case report].
    Orv Hetil 2017 Jul;158(27):1067-1070
    Patológiai Osztály, Bács-Kiskun Megyei Kórház Kecskemét, Nyíri út 38., 6000.
    Sarcoidosis is a systemic granulomatous disease of unknown aetiology, which is characterized by bilateral hilar lymphadenopathy and pulmonary disease. Clinically detected cardiac involvement occurs in 5% of sarcoid patients, although cardiac manifestations are discovered in 25% of the cases at autopsy. Sarcoid heart disease frequently causes atrioventricular block. Read More

    Incidence and Time Course for Developing Heart Failure With High-Burden Right Ventricular Pacing.
    Circ Cardiovasc Qual Outcomes 2017 Jun;10(6)
    From the Cardiology Division, Emory University School of Medicine, Atlanta, GA (F.M.M., M.H.H.); Cardiology Division, Valley Health System, Ridgewood, NJ (D.L.M., S.M.); and Abbott, Sunnyvale, CA (J.B.P., G.J.R., Y.N.).
    Background: Although right ventricular pacing can contribute to cardiomyopathy, the impact of complete atrioventricular block (cAVB) on heart failure (HF) development in pacemaker patients has not been well characterized. We evaluated the incidence and time course for developing HF after pacemaker implantation for cAVB.

    Methods And Results: A MarketScan database identified patients undergoing dual-chamber pacemaker implantation from 2008 to 2014. Read More

    Clinical Characteristics and Outcomes of Patients with Ischemic and Non-Ischemic Complete Heart Block.
    Cureus 2017 May 12;9(5):e1244. Epub 2017 May 12.
    Electrophysiology, Fairview Hospital, Cleveland Clinic, USA.
    Introduction: Third degree or complete heart block (CHB) is a medical emergency and usually requires permanent pacemaker placement. CHB can be caused by cardiac ischemia or non-ischemic conditions such as infiltrative diseases or fibrosis. The purpose of this study is to identify the baseline clinical characteristics associated with ischemic versus non-ischemic causes of complete heart block and compare their outcomes. Read More

    Acute Idiopathic Gastric Distension Causing Atrioventricular Block and Cardiogenic Shock.
    J Emerg Med 2017 Sep 8;53(3):302-305. Epub 2017 Jun 8.
    Lakeland Healthcare Emergency Medicine Residency, Michigan State University College of Osteopathic Medicine, St. Joseph, Michigan.
    Background: We report a rare case of acute idiopathic gastric dilatation with associated severe bradycardia and shock.

    Case Report: A 69-year-old woman presented to the emergency department (ED) with complaint of chest pain and dyspnea. The patient required transvenous cardiac pacing for profound bradycardia and cardiogenic shock. Read More

    Timing of Onset and Outcome of New Conduction Abnormalities Following Transcatheter Aortic Valve Implantation: Role of Balloon Aortic Valvuloplasty.
    Rev Esp Cardiol (Engl Ed) 2017 May 27. Epub 2017 May 27.
    Department of Cardiology, Quebec Heart and Lung Institute, Quebec City, Canada. Electronic address:
    Introduction And Objectives: Little is known about the timing of onset and outcome of conduction abnormalities (CA) following balloon-expandable transcatheter aortic valve implantation. The aim of this study was to examine the timing of CA and determine the impact of balloon aortic valvuloplasty (BAV) on the persistence of these abnormalities.

    Methods: A total of 347 patients were included. Read More

    Early-onset Lyme carditis with concurrent disseminated erythema migrans.
    Am J Cardiovasc Dis 2017 15;7(2):53-56. Epub 2017 Apr 15.
    West Virginia University Heart and Vascular InstituteMorgantown, WV, USA.
    Background: Lyme disease is an infection that is estimated to affect over 300,000 people in the United States annually. Typically, it presents with erythema migrans (EM), an annular rash at the site of tick attachment, within 3 to 30 days of inoculation. Untreated patients may progress to early disseminated disease. Read More

    Discovery of a new mutation in the desmin gene in a young patient with cardiomyopathy and muscular weakness.
    Rom J Morphol Embryol 2017 ;58(1):225-230
    Department of Cardiology, "Prof. Dr. C. C. Iliescu" Institute of Emergency for Cardiovascular Diseases, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;
    A 25-year-old woman with a five years history of syncope, mild left ventricular hypertrophy and moderately enlarged atria, was diagnosed with third degree atrioventricular heart block alternating with atrioventricular heart block 2:1, and received a dual chamber pacemaker. After three years of evolution, she developed atrial fibrillation, marked biatrial enlargement, severely depressed longitudinal myocardial velocities, associated with mild girdle weakness and slight increase in creatine kinase level. The diagnosis of restrictive cardiomyopathy with mild skeletal myopathy imposed the screening for a common etiology. Read More

    Chronic Low Dose Prostaglandin and Neonatal Heart Block.
    Pediatr Cardiol 2017 May 16. Epub 2017 May 16.
    Department of Pediatrics, Division of Cardiology, Rush University Medical College, 1653 W. Congress Pkwy., Pavilion 654, Chicago, IL, 60612, USA.
    Long-term prostaglandin use is commonly associated with side effects such as cortical proliferation of the bones, hypertrophic pyloric stenosis, and soft tissue swelling of the extremities. We report a neonate with critical coarctation of the aorta, who developed second and third degree atrioventricular blocks associated with prolonged prostaglandin E1 (PGE1) infusion. Interestingly, these conduction blocks only occurred at low PGE1 dose. Read More

    Amiodarone-Induced Third Degree Atrioventricular Block and Extreme QT Prolongation Generating Torsade Des Pointes in Paroxysmal Atrial Fibrillation.
    J Atr Fibrillation 2016 Oct-Nov;9(3):1502. Epub 2016 Oct 31.
    Department of Health Sciences's Investigation. Sanatorio Metropolitano. Fernando de la Mora. Paraguay. Cardiology Department, Clinic Hospital, Asunción National University, San Lorenzo, Paraguay.
    Amiodarone is still the most potent antiarrhythmic drug in the prevention of life threatening ventricular arrhythmias and demonstrates a very low incidence of torsade de pointes. An unusual case of an 81-year-old woman who developed serious abnormalities of the conduction system of the heart and torsade des pointes during intravenous infusion of amiodarone for the treatment of paroxysmal atrial fibrillation is described. To the best of our knowledge, this is the first case showing an association of intravenous amiodarone-induced third degree atrioventricular block and extreme QT interval prolongation generating torsade des pointes in a patient with paroxysmal atrial fibrillation who required an implantable cardioverter-defibrillator. Read More

    Third-Degree Atrioventricular Block and Collapse Associated with Eosinophilic Myocarditis in a Horse.
    J Vet Intern Med 2017 May 14;31(3):884-889. Epub 2017 Mar 14.
    Department of Clinical Studies-New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA.
    Third-degree atrioventricular block (AVB) and primary inflammatory myocarditis are uncommon findings in horses. The horse of this report presented for collapse at rest and was found to have multiple cardiac arrhythmias, most notably 3rd-degree AVB. The horse was subsequently diagnosed with eosinophilic myocarditis on necropsy, a rare form of myocarditis not previously reported in horses. Read More

    A Case of Congenitally Corrected Transposition of Great Arteries: An Infrequent Happenstance.
    Case Rep Med 2017 9;2017:7565870. Epub 2017 Feb 9.
    NH Malla Reddy Narayana Multispeciality Hospital, Hyderabad, Telangana 500055, India.
    Congenitally corrected transposition of the great arteries (CCTGA) is rare form of congenital heart diseases. It may be present with or without associated anomalies. Patients with CCTGA are usually diagnosed at early stages of life due to associated anomalies, but they may even remain asymptomatic till later decades of their life. Read More

    Incidence, Predictors, and Outcomes of High-Grade Atrioventricular Block in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention (from the HORIZONS-AMI Trial).
    Am J Cardiol 2017 May 16;119(9):1295-1301. Epub 2017 Feb 16.
    Cardiovascular Research Foundation, Clinical Trials Center, New York, New York; Department of Cardiology, NewYork-Presbyterian Hospital, Columbia University Medical Center, New York, New York.
    High-grade atrioventricular block (HAVB) is historically considered a marker of worse outcomes in patients with ST-segment elevation myocardial infarction (STEMI). However, the predictors and prognostic impact of HAVB in the primary percutaneous coronary intervention (PCI) era remain poorly understood. We sought to describe the characteristics and predictors of HAVB in patients undergoing primary PCI in STEMI and to assess the prognostic significance of HAVB in the contemporary reperfusion era. Read More

    Cardiovascular Disease Update: Bradyarrhythmias.
    FP Essent 2017 Mar;454:18-23
    Naval Hospital Jacksonville, 2080 Child St, Jacksonville, FL 32212.
    Bradyarrhythmia (bradycardia) is a heart rate lower than 60 beats/min. It can be due to sinus, atrial, or junctional bradycardia or to a problem with the conduction system (eg, an atrioventricular block). Asymptomatic bradycardia is common, especially among trained athletes or during sleep. Read More

    Cervical plexus anesthesia versus general anesthesia for anterior cervical discectomy and fusion surgery: A randomized clinical trial.
    Medicine (Baltimore) 2017 Feb;96(7):e6119
    aDepartment of Spine Surgery bFinancial Statistics Office, The Third Hospital of HeBei Medical University cThe Orthopaedic Department From First Hospital of Shijiazhuang, Shijiazhuang, China.
    Both general anesthesia (GA) and cervical plexus anesthesia (CPA) can be used for anterior cervical discectomy and fusion (ACDF) surgery. The aim of this study was to evaluate the influence of anesthetic techniques on perioperative mortality and morbidity in patients undergoing cervical surgery.From January 2008 to December 2015, 356 patients who underwent 1-level ACDF for cervical spinal myelopathy were prospectively reviewed. Read More

    A rare cardiac tumor: Bronchogenic cyst of interatrial septum.
    Echocardiography 2017 Mar 31;34(3):474-475. Epub 2017 Jan 31.
    Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
    Intracardiac bronchogenic cysts are uncommon congenital tumors, which rarely become symptomatic. We describe a rare case of bronchogenic cyst in the atrioventricular node. A 36-year-old man with third-degree atrioventricular block was referred to our hospital. Read More

    Obstetric and perinatal outcome in anti-Ro/SSA-positive pregnant women: a prospective cohort study.
    Immunol Res 2017 Apr;65(2):487-494
    Obstetric and Gynecology Department, High Risk Pregnancy Unit, Autoimmune diseases and pregnancy clinic, University Hospital La Paz, Paseo de la Castella 261, 28046, Madrid, Spain.
    Anti-Ro/SS-A is one specific type of antinuclear antibodies. They are in the majority of cases associated with primary Sjögren syndrome (SS) but also in Systemic Lupus Erythematosus (SLE), rheumatoid arthritis (RA), and in healthy people. During pregnancy, they are mainly associated to congenital heart block (CHB) and neonatal lupus (NL). Read More

    Ro52 autoantibodies arise from self-reactive progenitors in a mother of a child with neonatal lupus.
    J Autoimmun 2017 May 22;79:99-104. Epub 2017 Jan 22.
    Dept. Medicine, Division of Rheumatology, New York University School of Medicine, New York, USA.
    The detection of cardiac conduction defects in an 18-24 week old foetus in the absence of structural abnormalities predicts with near certainty the presence of autoantibodies against 60kD and 52kD SSA/Ro in the mother regardless of her health status. Previous studies have emphasized these autoantibodies as key mediators of tissue injury. The aim of this study was to focus on the anti-Ro52 response to determine whether these autoantibodies originate from progenitors that are inherently self-reactive or from B-cells that acquire self-reactivity during an immune response. Read More

    Electrocardiographic assessments and cardiac events after fingolimod first dose - a comprehensive monitoring study.
    BMC Neurol 2017 Jan 18;17(1):11. Epub 2017 Jan 18.
    Charité Universitaetsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, Berlin, 13353, Germany.
    Background: First dose observation for cardiac effects is required for fingolimod, but recommendations on the extent vary. This study aims to assess cardiac safety of fingolimod first dose. Individual bradyarrhythmic episodes were evaluated to assess the relevance of continuous electrocardiogram (ECG) monitoring. Read More

    Development and impact of arrhythmias after the Norwood procedure: A report from the Pediatric Heart Network.
    J Thorac Cardiovasc Surg 2017 Mar 16;153(3):638-645.e2. Epub 2016 Nov 16.
    Division of Cardiovascular Sciences, The National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
    Objectives: The study objective was to determine the predictors of new-onset arrhythmia among infants with single-ventricle anomalies during the post-Norwood hospitalization and the association of those arrhythmias with postoperative outcomes (ventilator time and length of stay) and interstage mortality.

    Methods: After excluding patients with preoperative arrhythmias, we used data from the Pediatric Heart Network Single Ventricle Reconstruction Trial to identify risk factors for tachyarrhythmias (atrial fibrillation, atrial flutter, supraventricular tachycardia, junctional ectopic tachycardia, and ventricular tachycardia) and atrioventricular block (second or third degree) among 544 eligible patients. We then determined the association of arrhythmia with outcomes during the post-Norwood hospitalization and interstage period, adjusting for identified risk factors and previously published factors. Read More

    Safety of regadenoson stress testing in patients with pulmonary hypertension.
    J Nucl Cardiol 2016 Nov 28. Epub 2016 Nov 28.
    Division of Cardiovascular Medicine, Department of Internal Medicine and Frankel Cardiovascular Center, University of Michigan, 2nd Floor CVC / SPC 5853, 1500 E. Medical Center Dr.,, Ann Arbor, MI, 48109-5853, USA.
    Objectives: We sought to determine the safety of regadenoson stress testing in patients with PH.

    Background: PH is increasingly recognized at more advanced ages. As many as one-third of patients with PH have coronary artery disease. Read More

    Lyme Carditis: An Interesting Trip to Third-Degree Heart Block and Back.
    Case Rep Cardiol 2016 6;2016:5454160. Epub 2016 Nov 6.
    Department of Medicine, Memorial Hospital of Rhode Island, Alpert Medical School, Brown University, Pawtucket, RI, USA.
    Carditis is an uncommon presentation of the early disseminated phase of Lyme disease. We present the case of a young female who presented with erythema migrans and was found to have first-degree heart block which progressed to complete heart block within hours. After receiving ceftriaxone, there was complete resolution of the heart block in sequential fashion. Read More

    Complete Heart Block in Association with Dengue Hemorrhagic Fever.
    Korean Circ J 2016 Nov 13;46(6):866-869. Epub 2016 Oct 13.
    Department of Medicine, Johnson City Medical Center, Quillen College of Medicine, Johnson City, TN, USA.
    Dengue virus infection affects the heart structurally and functionally. Clinical manifestations of cardiac complications secondary to dengue virus infection vary from self-limiting arrhythmias to severe myocardial infarction, leading to hypotension, pulmonary edema, and cardiogenic shock. However, we report a case of dengue hemorrhagic fever (DHF) complicated by a complete heart block. Read More

    Syncope in patients paced for atrioventricular block.
    Europace 2016 Nov 6;18(11):1735-1739. Epub 2016 Feb 6.
    Arrhythmologic Centre, Department of Cardiology, Ospedali del Tigullio, Lavagna 16033, Italy
    Aims: Although syncope is the main reason for cardiac pacing in ∼40% of patients affected by atrioventricular block (AVB), very few data are available on the benefit of cardiac pacing in preventing syncopal recurrences.

    Methods And Results: We retrospectively evaluated 229 consecutive patients (124 males, age 80 ± 10 years) who had received a permanent pacemaker from January 2009 to December 2013 for AVB and syncope (94 patients, 41%) or AVB without syncope (135 patients, 59%). In patients with AVB and syncope, a third-degree or Mobitz II second-degree AVB had been documented in 73 and was only suspected in another 21, all of whom had bundle branch block. Read More

    Isolated congenital complete heart block in a five-year-old seronegative girl born to a woman seropositive for human immunodeficiency virus: a case report.
    J Med Case Rep 2016 Oct 19;10(1):288. Epub 2016 Oct 19.
    Department of Cardiovascular Medicine, The Jakaya Kikwete Cardiac Institute, P.O Box 65141, Dar es Salaam, Tanzania.
    Background: Congenital complete heart block is a life-threatening condition which is highly associated with autoimmune and connective tissue disorders. Presence of maternal autoantibodies for associated conditions increases the risk of delivering a child with congenital complete heart block, however, less than a half of all women with such antibodies are symptomatic even after delivery. Mortality rate is highest during the neonatal period (45 %) and about two-thirds of all cases will require permanent pacing at some point in their lives. Read More

    Paroxysmal atrioventricular block after heart transplantation in children: an early sign of rejection?
    Pediatr Transplant 2016 Dec 14;20(8):1164-1167. Epub 2016 Oct 14.
    Pediatric Cardiology and Cardiac Arrhythmias-Syncope Unit, Department of Pediatric Cardiology and Cardiac Surgery, Bambino Gesù Children's Hospital and Research Institute, Rome, Italy.
    In OHT recipients, pathologic evaluation of the heart during acute rejection can show involvement of both the conduction system and the myocardium. We here describe the cases of a 9-year-old male with DCM and a 13-year-old female with RCM, who developed third-degree PAVB associated with acute rejection 36 months and 24 months after OHT, respectively. We conclude that PAVB could be considered an early sign of acute rejection after OHT in children who exhibit post-transplantation presyncope or syncope. Read More

    Life-threatening cardiac episode in a Polish patient carrying contiguous gene microdeletion of the TBX5 and the TBX3 genes.
    Springerplus 2016 21;5(1):1638. Epub 2016 Sep 21.
    Department of Medical Genetics, Poznan University of Medical Sciences, Fredry 10, 61-701 Poznan, Poland ; NZOZ Center for Medical Genetics, GENESIS ul. Grudzieniec 4, 60-601 Poznan, Poland.
    Holt-Oram syndrome (HOS) features radial ray hypoplasia, heart defect and cardiac conduction impairment. Ulnar-mammary syndrome (UMS) characterizes congenital defects of the ulnar side of the upper limbs, underdevelopment of apocrine glands including hypoplasia and the dysfunction of mammary glands, hypogonadism and obesity. Inheritance of both conditions is autosomal dominant, mutations or deletions are found in the TBX5 and TBX3 gene, respectively. Read More

    Traumatic Gerbode ventricular septal defect and third-degree heart block.
    Cardiol Young 2017 Mar 19;27(2):404-406. Epub 2016 Sep 19.
    1Department of Pediatrics,Duke University,Durham,North Carolina,United States of America.
    We present an interesting and rare case of traumatic Gerbode ventricular septal defect and complete heart block. The multimodality images illustrate the diagnosis well. This case is an excellent demonstration of the diagnostic utility of multimodality imaging. Read More

    Safety and Tolerability of Neladenoson Bialanate, a Novel Oral Partial Adenosine A1 Receptor Agonist, in Patients With Chronic Heart Failure.
    J Clin Pharmacol 2017 Apr 9;57(4):440-451. Epub 2016 Nov 9.
    Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
    We studied safety and tolerability of neladenoson bialanate, a novel oral selective partial adenosine A1 receptor agonist that maintains the cardioprotective effects of adenosine without the undesired side effects of a full agonist, in 2 pilot studies in patients with heart failure with reduced ejection fraction (HFrEF). The β-blocker interaction study was a single-blind, placebo-controlled study on the effects of a 30-mg single dose of neladenoson bialanate on atrioventricular (AV) conduction in 11 patients with HFrEF treated with β-blockers. The PARSiFAL pilot study was a double-blind, placebo-controlled study on the effects of a 7-day treatment with 10 or 20 mg neladenoson bialanate or placebo in 31 patients with HFrEF on β-blocker therapy. Read More

    Second-Degree Atrioventricular Block Occurring After Tooth Extraction.
    Anesth Prog Fall 2016;63(3):156-9
    Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry, Tokyo, Japan.
    Although cardiac arrhythmias are occasionally associated with dental extractions and dental anesthesia, atrioventricular block is rarely seen during dental procedures. We report a rare case of type I second-degree atrioventricular block (Wenckebach phenomenon) occurring after bilateral extraction of impacted mandibular third molars under general anesthesia in a 16-year-old Japanese girl. Under consultation with a cardiovascular physician, we carefully monitored the patient's vital signs postoperatively, including blood pressure, oxygen saturation, and electrocardiogram, using a bedside monitor. Read More

    Complete heart block in pregnancy: case report, analysis, and review of anesthetic management.
    J Clin Anesth 2016 Sep 27;33:58-61. Epub 2016 Apr 27.
    Department of Anesthesiology, University of Miami Miller School of Medicine, C-300, 1611 NW 12 Ave, Miami, FL 33136 USA.
    Maternal complete heart block can pose significant challenges for the anesthesiologist in the antepartum, peripartum, and postpartum periods. Some patients may present for the first time in the puerperium with dizziness, weakness, syncope, or congestive heart failure as a result of the additional hemodynamic burden that accompanies pregnancy. Although there is an increase in permanent pacemaker placement in young symptomatic patients before pregnancy, prophylactic placement of pacemakers in asymptomatic parturients is not always indicated. Read More

    Identification of discrete epitopes of Ro52p200 and association with fetal cardiac conduction system manifestations in a rodent model.
    Clin Exp Immunol 2016 Dec 13;186(3):284-291. Epub 2016 Sep 13.
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
    Congenital heart block (CHB) is a potentially lethal condition characterized by a third-degree atrioventricular block (AVB). Despite anti-Ro52 antibodies being detected in nearly 90% of mothers of affected children, CHB occurs in only 1-2% of anti-Ro/Sjögren's-syndrome-related antigen A (SSA) autoantibody-positive pregnancies. Maternal antibodies have been suggested to bind molecules crucial to fetal cardiac function; however, it remains unknown whether a single antibody profile associates with CHB or whether several specificities and cross-reactive targets exist. Read More

    Transfemoral aortic valve implantation with the repositionable Lotus valve for treatment of patients with symptomatic severe aortic stenosis: results from a single-centre experience.
    EuroIntervention 2016 Aug;12(6):760-7
    Department of Internal Medicine II, University of Ulm, Ulm, Germany.
    Aims: The aim of the study was to evaluate the procedural and 30-day results for the repositionable Lotus valve in patients undergoing transfemoral aortic valve implantation in a single-centre experience.

    Methods And Results: We prospectively enrolled 110 patients with severe symptomatic aortic stenosis (NCT02162069). All procedures were performed without general anaesthesia by the transfemoral approach. Read More

    Conduction disorders in bradyasystolic out-of-hospital cardiac arrest.
    Resuscitation 2016 Sep 12;106:113-9. Epub 2016 Jul 12.
    Academic Medical Center - Department of Cardiology, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
    Aims: Bradyasystolic heart rhythms are often recorded in out-of-hospital cardiac arrest (OHCA). Atrioventricular (AV) conduction disorders might lead to OHCA, but the prevalence of AV-conduction disorders and other bradyasystolic rhythms in OHCA is unknown. These patients might benefit from pre-hospital pacing. Read More

    Left Bundle Branch Block and Complete Heart Block Complicating Inferior Myocardial Infarction.
    Ann Noninvasive Electrocardiol 2017 Jan 13;22(1). Epub 2016 Jul 13.
    Department of Internal Medicine, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY, USA.
    Left bundle branch block following inferior myocardial infarction remains uncommon and scarcely reported in the literature. We describe a rare presentation of a 58-year-old male patient who developed left bundle branch block and third degree atrioventricular block after inferior myocardial infarction requiring permanent pacemaker placement. Pathophysiology, impact on mortality, and management options are discussed. Read More

    Long-Term Follow-Up of Children with Heart Block Born from Mothers with Systemic Lupus Erythematosus: A Retrospective Study from the Database Pediatric and Congenital Heart Disease in University Hospitals Leuven.
    Pacing Clin Electrophysiol 2016 Sep 2;39(9):935-43. Epub 2016 Aug 2.
    Congenital and Structural Cardiology, University Hospitals Leuven, Leuven, Belgium.
    Background: Children from mothers with systemic lupus erythematosus are frequently born with congenital heart block. This study aimed at evaluating long-term outcome because long-term data are scarce.

    Methods: In the database of pediatric and congenital heart disease (University Hospitals Leuven), 19 children from systemic lupus erythematosus mothers and who were born with or developed atrioventricular block were identified. Read More

    Heart block following stage 1 palliation of hypoplastic left heart syndrome.
    J Thorac Cardiovasc Surg 2016 Jul 11;152(1):189-94. Epub 2016 Apr 11.
    Department of Cardiology, Boston Children's Hospital and Harvard Medical School, Boston, Mass.
    Objectives: Publicly available data from the Pediatric Heart Network's Single Ventricle Reconstruction Trial was analyzed to determine the prevalence, timing, risk factors for, and impact of second- and third-degree heart block (HB) on outcomes in patients who underwent stage 1 palliation (S1P) for hypoplastic left heart syndrome (HLHS).

    Methods: The presence and date of onset of post-S1P HB occurring within the first year of life, potential risk factors for HB, and factors known to predict poor outcomes after S1P were extracted. Multivariable logistic and Cox regression analyses were performed to identify risk factors for HB and to determine the effect of HB on 3-year transplantation-free survival. Read More

    Electrophysiological Mechanisms of Bayés Syndrome: Insights from Clinical and Mouse Studies.
    Front Physiol 2016 31;7:188. Epub 2016 May 31.
    Department of Medicine and Therapeutics, The Chinese University of Hong KongHong Kong, China; Department of Epidemiology and Preventive Medicine, Monash UniversityMelbourne, VIC, Australia.
    Bayés syndrome is an under-recognized clinical condition characterized by inter-atrial block (IAB). This is defined electrocardiographically as P-wave duration > 120 ms and can be categorized into first, second and third degree IAB. It can be caused by inflammatory conditions such as systemic sclerosis and rheumatoid arthritis, abnormal protein deposition in cardiac amyloidosis, or neoplastic processes invading the inter-atrial conduction system, such as primary cardiac lymphoma. Read More

    Mobitz type I and II atrioventricular blocks during fingolimod therapy.
    Neurol Sci 2016 Sep 25;37(9):1557-9. Epub 2016 May 25.
    Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, Via Pansini, 5, 80131, Naples, Italy.
    We investigated patients who showed a second-degree atrioventricular block (S-AVB) after the first fingolimod administration. We observed six patients with S-AVB, three Mobitz type I, and three type II. Monitoring continued on the second day for all patients. Read More

    Incidence and characteristics of heart block after heart surgery in pediatric patients: A multicenter study.
    J Thorac Cardiovasc Surg 2016 Jul 7;152(1):197-202. Epub 2016 May 7.
    Division of Pediatric Cardiology, Department of Pediatrics, New York-Presbyterian/Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.
    Background: Advanced second- or third-degree heart block has been reported with variable incidence after surgery for congenital heart disease in children. We report the incidence of heart block requiring a pacemaker and describe the risk factors for this complication in a large multicenter study.

    Methods: We performed a retrospective cohort study, using the Pediatric Health Information System database from 45 hospitals in the United States, for all children aged 18 years, discharged between January 1, 2004, and December 31, 2013, who underwent open surgery for congenital heart disease. Read More

    Continuous intraoperative monitoring of vagus and recurrent laryngeal nerve function in patients with advanced atrioventricular block.
    Langenbecks Arch Surg 2016 Jun 30;401(4):551-6. Epub 2016 Apr 30.
    Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube-Straße 40, 06120, Halle (Saale), Germany.
    Purpose: Intraoperative neuromonitoring of recurrent laryngeal nerve function after stimulation of the vagus nerve has been embraced as a risk minimization tool in thyroid surgery to prevent recurrent laryngeal nerve injury. Because this technology is increasingly used in an elderly and sicker population, the present study was conducted to determine the safety of this method in patients with second- or third-degree atrioventricular block.

    Methods: This study aimed at evaluating the feasibility and safety of continuous intraoperative neuromonitoring (CIONM) in patients with second- or third-degree atrioventricular block. Read More

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