1,407,151 results match your criteria Heart Block Second Degree


The appropriateness of coronary investigation in myocardial injury and type 2 myocardial infarction (ACT-2): A randomized trial design.

Am Heart J 2018 Oct 25;208:11-20. Epub 2018 Oct 25.

Department of Cardiology, Flinders Medical Centre, Adelaide, Australia; College of Medicine and Public Health, Flinders University of South Australia, Adelaide, Australia. Electronic address:

Background: Elevated troponin level findings among patients presenting with suspected acute coronary syndrome (ACS) or another intercurrent illness undeniably identifies patients at increased risk of mortality. Whilst enhancing our capacity to discriminate risk, the use of high-sensitivity troponin assays frequently identifies patients with myocardial injury (i.e. Read More

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October 2018
3 Reads

Impact of short-term traffic-related air pollution on the metabolome - Results from two metabolome-wide experimental studies.

Environ Int 2018 Dec 3;123:124-131. Epub 2018 Dec 3.

MRC/PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Italian Institute for Genomic Medicine (IIGM), Turin, Italy. Electronic address:

Exposure to traffic-related air pollution (TRAP) has been associated with adverse health outcomes but underlying biological mechanisms remain poorly understood. Two randomized crossover trials were used here, the Oxford Street II (London) and the TAPAS II (Barcelona) studies, where volunteers were allocated to high or low air pollution exposures. The two locations represent different exposure scenarios, with Oxford Street characterized by diesel vehicles and Barcelona by normal mixed urban traffic. Read More

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December 2018
4 Reads

Left Atrial Appendage Closure Device Implantation in Patients with Prior Intracranial Hemorrhage.

Heart Rhythm 2018 Nov 19. Epub 2018 Nov 19.

Section of Cardiac Pacing and Electrophysiology, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH. Electronic address:

Background: The Watchman™ device (Boston Scientific, MN), used for left atrial appendage closure (LAAC) was approved for stroke prevention in patients with atrial fibrillation (AF) and an appropriate rationale to avoid long-term oral anticoagulation. Patients with AF and prior intracranial hemorrhage (ICH) were excluded from clinical trials due to perceived risks of peri-operative anticoagulation.

Objective: We studied the efficacy and safety of LAAC using Watchman™ in patients with AF and prior ICH. Read More

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November 2018

Cardiovascular development and survival require Mef2c function in the myocardial but not the endothelial lineage.

Dev Biol 2018 Dec 3. Epub 2018 Dec 3.

Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, 94143, USA. Electronic address:

MEF2C is a member of the highly conserved MEF2 family of transcription factors and is a key regulator of cardiovascular development. In mice, Mef2c is expressed in the developing heart and vasculature, including the endothelium. Loss of Mef2c function in germline knockout mice leads to early embryonic demise and profound developmental abnormalities in the cardiovascular system. Read More

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December 2018

Healthcare Providers' Advice on Lifestyle Modification in the US Population: Results from the National Health and Nutrition Examination Survey 2011-2016.

Am J Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Epidemiology, Center for Public Health, Medical University of Vienna, Kinderspitalgasse 15/1, 1090 Vienna, Austria; Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Holy Cross Centre, 2210-2nd Street SW, Box ACB, Calgary, AB, T2S 3C3, Canada; Preventive Oncology & Community Health Sciences, Cumming School of Medicine, University of Calgary, Hospital Drive NW, Calgary, Alberta, Canada. Electronic address:

Objective: Healthcare providers are encouraged to prescribe lifestyle modifications for preventing and managing obesity and associated chronic conditions. However, the pattern of lifestyle advice provision is unknown. We investigate the prevalence of advised lifestyle modification according to weight status and chronic conditions in a US nationally representative sample. Read More

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December 2018

A risk-scoring model for the prediction of delayed bleeding after colorectal endoscopic submucosal dissection.

Gastrointest Endosc 2018 Dec 3. Epub 2018 Dec 3.

Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. Electronic address:

Background And Aims: Delayed bleeding is an important adverse event after colorectal endoscopic submucosal dissection (ESD). We aimed to investigate the incidence and risk factors of delayed bleeding after colorectal ESD, and to develop a risk scoring model for predicting delayed bleeding.

Methods: This retrospective multicenter study was performed at 5 centers. Read More

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December 2018
1 Read

Is physical activity associated with resting heart rate in boys and girls? A representative study controlled for confounders.

J Pediatr (Rio J) 2018 Dec 3. Epub 2018 Dec 3.

Universidade Estadual Paulista, Departamento de Educação Física, Presidente Prudente, SP, Brazil. Electronic address:

Objective: Investigate the relationship between different domains of physical activity and resting heart rate (RHR) in boys and girls.

Method: The sample included 1011 adolescents, aged between 10 and 17 years. RHR was measured by a heart rate monitor and physical activity was assessed in total and in three different domains (school, occupational, and sports practice) by a questionnaire. Read More

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December 2018

Intensive versus standard multifactorial cardiovascular risk factor control in screen-detected type 2 diabetes: 5 year and longer-term modelled outcomes of the ADDITION-Leicester study.

Diabetes Metab Res Rev 2018 Dec 6:e3111. Epub 2018 Dec 6.

Leicester Diabetes Centre, University of Leicester, Leicester, UK.

Aims: Diabetes treatment algorithms recommend intensive intervention in those with a shorter duration of disease. Screening provides opportunities for earlier multifactorial cardiovascular risk factor control. Using data from the ADDITION-Leicester study (NCT00318032), we estimated the effects of this approach on modelled risk of diabetes related complications in screen-detected patients. Read More

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December 2018
1 Read

Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.

Cochrane Database Syst Rev 2018 11 30;11:CD003177. Epub 2018 Nov 30.

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, Norfolk, UK, NR4 7TJ.

Background: Researchers have suggested that omega-3 polyunsaturated fatty acids from oily fish (long-chain omega-3 (LCn3), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)), as well as from plants (alpha-linolenic acid (ALA)) benefit cardiovascular health. Guidelines recommend increasing omega-3-rich foods, and sometimes supplementation, but recent trials have not confirmed this.

Objectives: To assess effects of increased intake of fish- and plant-based omega-3 for all-cause mortality, cardiovascular (CVD) events, adiposity and lipids. Read More

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November 2018
6 Reads

Atypical and severe manifestations of chikungunya virus infection in French Guiana: A hospital-based study.

PLoS One 2018 6;13(12):e0207406. Epub 2018 Dec 6.

Tropical and Infectious Diseases Department, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana.

Background: French Guiana (FG) was the first country in South America to declare chikungunya virus infection (CHIKV). The outbreak affected about 16,000 persons between February 2014 and October 2015, with several atypical cases, but only two fatal cases. We aimed to describe the clinical presentation of patients hospitalized for CHIKV infection, to estimate and identify risk factors of unusual and severe forms in adult patients. Read More

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December 2018

Effectiveness of influenza and pneumococcal polysaccharide vaccines against influenza-related outcomes including pneumonia and acute exacerbation of cardiopulmonary diseases: Analysis by dominant viral subtype and vaccine matching.

PLoS One 2018 6;13(12):e0207918. Epub 2018 Dec 6.

Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.

Background: Influenza and pneumonia are leading causes of morbidity and mortality among the elderly. Although vaccination is a main strategy to prevent these infectious diseases, concerns remain with respect to vaccine effectiveness.

Methods: During three influenza seasons (2014-2015, 2015-2016 and 2016-2017), we evaluated the effectiveness of the influenza and pneumococcal vaccines against pneumonia and acute exacerbation of cardiopulmonary diseases among the elderly aged ≥65 years with influenza-like illness (ILI). Read More

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December 2018
1 Read

Baroreflex function, haemodynamic responses to an orthostatic challenge, and falls in haemodialysis patients.

PLoS One 2018 6;13(12):e0208127. Epub 2018 Dec 6.

Queen Margaret University, Centre of Health, Activity and Rehabilitation Research, Edinburgh, United Kingdom.

Background: Stage 5 chronic kidney disease patients on haemodialysis (HD) often present with dizziness and pre-syncopal events as a result of the combined effect of HD therapy and cardiovascular disease. The dysregulation of blood pressure (BP) during orthostasis may be implicated in the aetiology of falls in these patients. Therefore, we explored the relationship between baroreflex function, the haemodynamic responses to a passive orthostatic challenge, and falls in HD patients. Read More

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December 2018
1 Read

Association between metabolic parameters and glomerular hyperfiltration in a representative Korean population without chronic kidney disease.

PLoS One 2018 6;13(12):e0207843. Epub 2018 Dec 6.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.

Aims: To investigate associations of glomerular hyperfiltration with other metabolic factors in a nationally representative dataset.

Methods: We analyzed cross-sectional data from 15,918 subjects with estimated glomerular filtration rate (eGFR) >60 ml/min/1.73 m2 and urine albumin creation ratio (ACR) <30 mg/g, who participated in the 5th and 6th Korea National Health and Nutrition Examination Surveys. Read More

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December 2018

Risk factors for recoarctation of aorta after Norwood procedure in patients with hypoplastic left heart syndrome.

Folia Med Cracov 2018 ;58(3):11-21

Department of Pediatric Cardiac Surgery, University Children's Hospital, Jagiellonian University Medical College, Wielicka 265, Kraków, Poland.

Background: Recoarctation (reCoA) of the aorta is a common complication afer the Norwood procedure. Untreated, it can lead to failure of the systemic ventricle and death. The main goal of the study is to define risk factors of reCoA after the Norwood procedure in hypoplastic left heart syndrome (HLHS). Read More

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January 2018

Exposure to Secondhand Smoke Among Nonsmokers - United States, 1988-2014.

MMWR Morb Mortal Wkly Rep 2018 Dec 7;67(48):1342-1346. Epub 2018 Dec 7.

Exposure to secondhand smoke from burning tobacco products can cause sudden infant death syndrome, respiratory infections, ear infections, and asthma attacks in infants and children, and coronary heart disease, stroke, and lung cancer in adult nonsmokers (1). There is no risk-free level of secondhand smoke exposure (2). CDC analyzed questionnaire and laboratory data from the National Health and Nutrition Examination Survey (NHANES) to assess patterns of secondhand smoke exposure among U. Read More

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December 2018
2 Reads

Beneficial effects of combined therapy with lacidipine and candesartan in obese hypertensive patients.

Rom J Intern Med 2018 Dec;56(4):257-264

Kharkiv National Medic University, Nauky Ave., Kharkiv, Ukraine.

Introduction: Obesity is becoming one of the leading risk factors of coronary heart disease, hypertension, cerebrovascular disease. Despite the presence of a large number of antihypertensive agents and scientific substantiation of antihypertensive treatment principles it would be wrong to assume that the problem is completely solved. Development of endothelial dysfunction is one of the key pathogenic mechanisms in hypertension. Read More

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December 2018
1 Read

Effects of weight loss on dynamic hyperinflation in women obese asthmatics.

J Appl Physiol (1985) 2018 Dec 6. Epub 2018 Dec 6.

Physical Therapy, School of Medicine, Brazil.

Obese adults with asthma are more likely to develop dynamic hyperinflation (DH) and expiratory flow limitation (EFL) than non-obese asthmatics, and weight-loss seems to improve the breathing mechanics during exercise. However, studies evaluating the effect of weight-loss on DH in obese adults with asthma have not been performed.

Objective: To evaluate the effect of a weight-loss program on DH in obese adults with asthma. Read More

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December 2018

Urine Catecholamines in Children with Severe Enterovirus A71 infection: Comparison with Paediatric Septic Shock.

Biomarkers 2018 Dec 6:1-15. Epub 2018 Dec 6.

a Children's Medical Center , Taichung Veterans General Hospital , Taichung , Taiwan.

Purpose: Hypercatecholaminemia-related heart failure has been proposed as the main cause of enterovirus A71-related (EV-A71) early mortality. The purpose of this study was to measure urine catecholamine concentrations in severe EV-A71-infected children.

Methods: A total of 35 children, aged 2. Read More

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December 2018

Hemodynamic Responses to an Exercise Stress Test in Parkinson's Disease Patients without Orthostatic Hypotension.

Appl Physiol Nutr Metab 2018 Dec 6. Epub 2018 Dec 6.

University of Miami, Kinesiology and Sport Sciences, Coral Gable, Florida, United States ;

The presence of postganglionic sympathetic denervation is well established in Parkinson's disease (PD). Denervation at cardiac and blood vessel sites may lead to abnormal cardiovascular and hemodynamic responses to exercise. The aim of the present investigation was to examine how heart rate (HR) and hemodynamics are affected by an exercise test in PD patients without orthostatic hypotension. Read More

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December 2018

Pulmonary embolectomy in a case of subacute pulmonary embolism, with previous unsuccessful fibrinolysis

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):418-423. Epub 2018 Nov 30.

Universidad Nacional Autónoma de México, Facultad de Medicina, División de Estudios de Posgrado. Ciudad de México, México

Background: Pulmonary embolism is a potentially fatal heart condition that requires prompt restoration of blood flow in the pulmonary vascular bed and prevention of recurrent events. Mortality is associated to the degree of hemodynamic repercussion, complications and opportunity in the treatment.

Case Report: Male 33 years of age who began with sudden dyspnea, chest pain of moderate intensity, sweating and syncope. Read More

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November 2018

Extracorporeal membrane oxygenation as a bridge for heart transplantation by Chagas cardiomyopathy

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):429-433. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Cardiología, Servicio de Anestesiología. Ciudad de México, México

Background: Extracorporeal membrane oxygenation is a technique indicated in cases of severe respiratory failure or in situations where pump failure or heart failure is refractory to conventional medical treatment. Our goal was to describe the results of a patient with chronic Chagas dilated cardiomyopathy treated with extracorporeal membrane oxygenation as bridging therapy for heart transplantation.

Case Report: A 62-year old male with a history of Chagas disease and severe ventricular failure who underwent veno-arterial extracorporeal membrane oxygenation as bridging therapy for heart transplantation, with good clinical evolution. Read More

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November 2018
2 Reads

Reproducibility of measuring QRS duration and implications for optimization of interventricular pacing delay in cardiac resynchronization therapy.

Ann Noninvasive Electrocardiol 2018 Dec 6:e12621. Epub 2018 Dec 6.

Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark.

Background: QRS narrowing after CRT is a predictor of patient outcome. Further narrowing can be obtained by interventricular pacing delay (VVd) optimization, raising interest to inter and intraobserver variation in manual measurements of QRS duration.

Methods: (a) Variation in intrinsic rhythm QRS duration in CRT patients with LBBB: In 40 intrinsic 12-lead ECGs, six observers measured QRS duration defined as widest QRS in any lead. Read More

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December 2018
1 Read

Gallic Acid Suppresses Cardiac Hypertrophic Remodeling and Heart Failure.

Mol Nutr Food Res 2018 Dec 6:e1800807. Epub 2018 Dec 6.

Dr. X. Yan, Y.-L. Zhang, L. Zhang, L.-X. Zou, C. Chen, Prof. Y. Liu, Prof. Y.-L. Xia, Prof. H.-H. Li, Department of Nutrition and Food Hygiene, School of Public Health, Dalian Medical University, Dalian, 116044, China.

Scope: Gallic acid (GA) is a dietary phenolic acid found in tea, red wine, and some plants. It exhibits antioxidative and anti-inflammatory activities. Recent studies have revealed that GA has beneficial effects against several cardiovascular diseases; however, whether GA attenuates pressure overload-induced cardiac hypertrophy and the underlying mechanism remain unclear. Read More

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December 2018
2 Reads

Differential associations of depression-related phenotypes with cardiometabolic risks: Polygenic analyses and exploring shared genetic variants and pathways.

Depress Anxiety 2018 Dec 6. Epub 2018 Dec 6.

School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong.

Background: Numerous studies have suggested associations between depression and cardiometabolic (CM) diseases. However, little is known about the mechanism underlying this comorbidity, and whether the relationship differs by depression subtypes.

Methods: Using polygenic risk scores (PRS) and linkage disequilibrium (LD) score regression, we investigated the genetic overlap of various depression-related phenotypes with a comprehensive panel of 20 CM traits. Read More

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December 2018

Polygenic risk score identifies associations between sleep duration and diseases determined from an electronic medical record biobank.

Sleep 2018 Dec 5. Epub 2018 Dec 5.

Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA USA.

Study Objectives: We aimed to detect cross-sectional phenotype and polygenic risk score (PRS) associations between sleep duration and prevalent diseases using the Partners Biobank, a hospital-based cohort study linking electronic medical record (EMR) with genetic information.

Methods: Disease prevalence was determined from EMR, and sleep duration was self-reported. A PRS for sleep duration was derived using 78 previously associated SNPs from GWAS for self-reported sleep duration. Read More

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December 2018

Predictors associated with an increased prevalence of postimplantation syndrome after thoracic endovascular aortic repair for type B aortic dissection.

Eur J Cardiothorac Surg 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiology, Vascular Center, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Objectives: The aim of this study was to identify patients who are at high risk of developing postimplantation syndrome (PIS) after thoracic endovascular aortic repair (TEVAR) for type B aortic dissection.

Methods: This retrospective study included 646 patients who underwent TEVAR for type B aortic dissection between January 2010 and December 2015 at the Guangdong General Hospital. PIS was defined as fever (>38°C) and leucocytosis (>12 000 μl-1) without evidence of infection. Read More

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December 2018

Heart Rate Variability Predicts Older Adults' Avoidance of Negativity.

J Gerontol B Psychol Sci Soc Sci 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychology, University of Warwick, Coventry, UK.

Objectives: The ability to produce situation-appropriate cognitive and emotional responses is dependent on autonomic nervous system (ANS) functionality. Heart rate variability (HRV) is an index of ANS functionality, and resting HRV levels have been associated with cognitive control and inhibitory capacity in young adults, particularly when faced with emotional information. As older adults' greater preference for positive and avoidance of negative stimuli (positivity effect) is thought to be dependent on cognitive control, we hypothesized that HRV could predict positivity-effect magnitude in older adults. Read More

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December 2018
2 Reads

LONG-TERM HEALTH RISK AFTER BREAST-CANCER RADIOTHERAPY: OVERVIEW OF PASSOS METHODOLOGY AND SOFTWARE.

Radiat Prot Dosimetry 2018 Dec 6. Epub 2018 Dec 6.

Klinik für Strahlentherapie, Universität Leipzig, Stephanstr. 9a, Leipzig, Germany.

Breast-cancer radiotherapy reduces the recurrence rates and improves patient survival. However, it also increases the incidence of second cancers and of heart disease. These radiation-induced long-term health risks become increasingly important with improved cure rates and prolonged patient survival. Read More

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December 2018

Prospective, randomized trial of bioresorbable scaffolds vs. everolimus-eluting stents in patients undergoing coronary stenting for myocardial infarction: the Intracoronary Scaffold Assessment a Randomized evaluation of Absorb in Myocardial Infarction (ISAR-Absorb MI) trial.

Eur Heart J 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiovascular Diseases, Deutsches Herzzentrum München, Technische Universität München, Lazarettstrasse 36, Munich, Germany.

Aims: Bioresorbable scaffolds (BRS) provide short-term coronary artery scaffolding and drug delivery. Although prior trials showed a higher rate of device failure compared with conventional drug-eluting stents (DES), only a single trial investigated patients undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction (MI). We aimed to compare outcomes with BRS vs. Read More

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December 2018

Pretest probability for patients with suspected obstructive coronary artery disease: re-evaluating Diamond-Forrester for the contemporary era and clinical implications: insights from the PROMISE trial.

Eur Heart J Cardiovasc Imaging 2018 Dec 5. Epub 2018 Dec 5.

Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 165 Cambridge Street, Suite 400, Boston, USA.

Aims: To update pretest probabilities (PTP) for obstructive coronary artery disease (CAD ≥ 50%) across age, sex, and clinical symptom strata, using coronary computed tomography angiography (CTA) in a large contemporary population of patients with stable chest pain referred to non-invasive testing.

Methods And Results: We included patients enrolled in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial and randomized to CTA. Exclusively level III-certified readers, blinded to demographic and clinical data, assessed the prevalence of CAD ≥ 50% in a central core lab. Read More

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December 2018
1 Read

[Usefulness, timing and modality of ECG stress testing after myocardial revascularization].

G Ital Cardiol (Rome) 2018 Dec;19(12):692-704

Istituto di Cardiologia, Università degli Studi, Pisa.

Myocardial revascularization in patients with stable ischemic heart disease aims at eliminating myocardial ischemia, in order to (i) relieve anginal symptoms; (ii) improve functional capacity; and, possibly, (iii) improve prognosis. Given that ischemic recurrences are relatively common in patients undergoing myocardial revascularization, an appropriate follow-up is needed as part of a secondary prevention program. Stress testing can be here useful to: (i) detect residual or recurrent ischemia/angina; (ii) define functional capacity in order to establish physical aerobic training individualized programs; (iii) stratify prognosis. Read More

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December 2018
1 Read

[Clinical applications of cardiac magnetic resonance imaging: heart failure and cardiomyopathies].

G Ital Cardiol (Rome) 2018 Dec;19(12):679-691

Dipartimento Cardiovascolare, ASST Papa Giovanni XXIII, Bergamo.

Cardiac magnetic resonance (CMR) has proved to be a powerful tool in the assessment of several cardiac diseases, thanks to its capability to offer multiparametric morphologic and functional evaluation of the heart and great vessels, using neither ionizing radiations nor nephrotoxic contrast medium. The accuracy in quantification of cardiac volumes and ejection fraction (gold standard) together with native and post-contrast myocardial tissue characterization have made CMR an invaluable tool for the diagnosis, prognosis and therapeutic planning in patients with heart failure and cardiomyopathy. Read More

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December 2018
2 Reads

[Journey around the heart in the movies of the last century: from Charlie Chaplin to the present day].

Authors:
Andrea Pozzati

G Ital Cardiol (Rome) 2018 Dec;19(12):664-667

U.O.S. Cardiologia, Ospedale Dossetti di Bazzano (BO), AUSL di Bologna.

Imagine a journey through the cinema's history to recover the figure of the doctor in the last century. At the same time, we have found that the progress of medicine has conditioned the stories told on the big screen. Cardiology has achieved a leading role at the cinema when technological innovations have begun to emerge, from the '60s onwards. Read More

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December 2018
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