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    The Bridge Occlusion Balloon as a safety net in a high-risk transvenous lead extraction procedure.
    Interact Cardiovasc Thorac Surg 2017 Sep 8. Epub 2017 Sep 8.
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany.
    Injuries to the superior vena cava (SVC) during transvenous lead extraction (TLE) procedures are a rare but life-threatening complication. The Bridge Occlusion Balloon (BOB) is specifically designed for temporary SVC occlusion in TLE procedures. We report the first case of a 27-year-old man using the BOB as a safety net in a high-risk TLE procedure. Read More

    Relation of elevated serum uric acid levels to first-degree heart block and other cardiac conduction defects in hospitalized patients with type 2 diabetes.
    J Diabetes Complications 2017 Sep 20. Epub 2017 Sep 20.
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
    Aims: Several studies have reported that moderately elevated serum uric acid levels are associated with an increased risk of tachyarrhythmias (mainly atrial fibrillation) in patients with and without type 2 diabetes mellitus (T2DM). It is currently unknown whether an association also exists between elevated serum uric acid levels and cardiac conduction defects in patients with T2DM.

    Methods: We retrospectively analyzed a hospital-based sample of 967 patients with T2DM discharged from our Division of Endocrinology over the years 2007-2014. Read More

    Arrhythmias in Type 2 Diabetes Mellitus.
    Indian J Endocrinol Metab 2017 Sep-Oct;21(5):715-718
    Department of Medicine, Nalanda Medical College Hospital, Patna, Bihar, India.
    Chronic hyperglycaemia of Type 2 diabetes mellitus causes long term damage to heart resulting in coronary artery disease (CAD), myocardial infarction (MI), congestive heart failure (CHF), and sudden death from arrhythmias.

    Aims: To study the prevalence of different types of arrhythmias in T2DM, particularly in association with Cardiac Autonomic Neuropathy (CAN).

    Methods: A cross-sectional study including 100 patients of Type 2 Diabetes Mellitus (T2DM) presenting with cardiac arrhythmias, was done at our hospital over 2 years. Read More

    Nonalcoholic fatty liver disease is associated with an increased risk of heart block in hospitalized patients with type 2 diabetes mellitus.
    PLoS One 2017 5;12(10):e0185459. Epub 2017 Oct 5.
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
    Recent studies suggested that nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiac tachyarrhythmias (mainly atrial fibrillation) in patients with and without type 2 diabetes mellitus. The aim of this study was to examine whether an association also exists between NAFLD and heart block. We have retrospectively evaluated a hospital-based cohort of 751 patients with type 2 diabetes discharged from our Division of Diabetes and Endocrinology during years 2007-2014. Read More

    Impact of waterborne and trophic mercury exposures on cardiac function of two ecologically distinct Neotropical freshwater fish Brycon amazonicus and Hoplias malabaricus.
    Comp Biochem Physiol C Toxicol Pharmacol 2017 Oct 20;201:26-34. Epub 2017 Sep 20.
    Department of Physiological Sciences, Federal University of São Carlos (UFSCar), São Carlos 13565-905, São Paulo, Brazil.
    Metal pollutants have been considered one of the main factors underlying the depletion of biodiversity in natural populations unbalancing aquatic environments. The aim of this study was to evaluate the effects of exposure to inorganic Hg on myocardial contractility and the electrocardiogram (ECG) of two ecologically distinct Neotropical fish species, namely: matrinxã (Brycon amazonicus) and trahira (Hoplias malabaricus). Matrinxãs were exposed to a sublethal concentration of 0. Read More

    Predictors of permanent pacemaker implantation after transfemoral aortic valve implantation with the Lotus valve.
    Am Heart J 2017 Oct 19;192:57-63. Epub 2017 Jul 19.
    Department of Internal Medicine II, University of Ulm, Ulm, Germany. Electronic address:
    Background: Permanent pacemaker implantation (PPMI) after transcatheter aortic valve implantation is of high clinical relevance, but PPMI rates differ widely between valve types. Although the Lotus valve can be repositioned, reported rates for PPMI are high. The predictors of PPMI after Lotus valve implantation have not been defined yet. Read More

    Prevalence, predictors, and prognostic implications of PR interval prolongation in patients with heart failure.
    Clin Res Cardiol 2017 Sep 15. Epub 2017 Sep 15.
    Department of Academic Cardiology, Castle Hill Hospital, University of Hull, Level 1 Daisy Building, Castle Road, Hull, HU16 5JQ, UK.
    Aims: To determine the prevalence, incidence, predictors, and prognostic implications of PR interval prolongation in patients referred with suspected heart failure.

    Methods And Results: Consecutive patients referred with suspected heart failure were prospectively enrolled. After excluding patients with implantable cardiac devices and atrial fibrillation, 1420 patients with heart failure and reduced ejection fraction (HeFREF) [age: median 71 (interquartile range IQR 63-78) years; men: 71%; NT-ProBNP: 1319 (583-3378) ng/L], 1094 with heart failure and normal ejection fraction (HeFNEF) [age: 76 (70-82) years; men: 47%; NT-ProBNP: 547 (321-1171) ng/L], and 1150 without heart failure [age: 68 (60-75) years; men: 51%; NT-ProBNP: 86 (46-140) ng/L] were included. Read More

    Very low pacemaker rate following ACURATE neo transcatheter heart valve implantation.
    EuroIntervention 2017 Sep 5. Epub 2017 Sep 5.
    Heart Center Lucerne, Luzerner Kantonsspital, Lucerne, Switzerland.
    Aims: Investigate if minimizing trauma to the aortic annulus and left ventricular outflow tract reduces the occurrence of new conduction disorders and need for permanent pacemakers.

    Methods And Results: A total of 175 patients (58% women, mean age 83 ± 6 years) underwent transfemoral TAVI with the Boston Scientific ACURATE neo at three centers in Europe. Prosthesis size selection was based on perimeter derived annular diameter. Read More

    Kinetics of spontaneous filament nucleation via oligomers: Insights from theory and simulation.
    J Chem Phys 2016 Dec;145(21):211926
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
    Nucleation processes are at the heart of a large number of phenomena, from cloud formation to protein crystallization. A recently emerging area where nucleation is highly relevant is the initiation of filamentous protein self-assembly, a process that has broad implications in many research areas ranging from medicine to nanotechnology. As such, spontaneous nucleation of protein fibrils has received much attention in recent years with many theoretical and experimental studies focussing on the underlying physical principles. Read More

    The use of non-invasive fetal electrocardiography in diagnosing second-degree fetal atrioventricular block.
    Matern Health Neonatol Perinatol 2017 3;3:14. Epub 2017 Aug 3.
    Institute of Biomedical Engineering, University of Oxford, Oxford, UK.
    Background: Complete atrioventricular block in fetuses is known to be mostly associated with autoimmune disease and can be irreversible if no steroids treatment is provided. Conventional methods used in clinical practice for diagnosing fetal arrhythmia are limited since they do not reflect the primary electrophysiological conduction processes that take place in the myocardium. The non-invasive fetal electrocardiogram has the potential to better support fetal arrhythmias diagnosis through the continuous analysis of the beat to beat variation of the fetal heart rate and morphological analysis of the PQRST complex. Read More

    Bone marrow cell migration to the heart in a chimeric mouse model of acute chagasic disease.
    Mem Inst Oswaldo Cruz 2017 Aug;112(8):551-560
    Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
    Background: Chagas disease is a public health problem caused by infection with the protozoan Trypanosoma cruzi. There is currently no effective therapy for Chagas disease. Although there is some evidence for the beneficial effect of bone marrow-derived cells in chagasic disease, the mechanisms underlying their effects in the heart are unknown. Read More

    Conduction disturbance after isolated surgical aortic valve replacement in degenerative aortic stenosis.
    J Thorac Cardiovasc Surg 2017 Nov 15;154(5):1556-1565.e1. Epub 2017 Jun 15.
    Department of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
    Objective: Conduction disturbances are common in patients with aortic stenosis. We investigated the incidence, reversibility, and prognosis of conduction disorders requiring permanent pacemaker implantation in patients with degenerative aortic stenosis after isolated aortic valve replacement.

    Methods: This was a retrospective study conducted at a tertiary care center. Read More

    Recovery of atrioventricular conduction in patients with heart block after transcatheter aortic valve replacement.
    J Cardiovasc Electrophysiol 2017 Oct 4;28(10):1196-1202. Epub 2017 Aug 4.
    Division of Cardiology, Department of Medicine, Weill Cornell Medical Center, New York, NY, USA.
    Introduction: Recovery of conduction has been demonstrated in >50% of patients who receive pacemakers (PPMs) for high-degree atrioventricular block (HD-AVB) after transcatheter aortic valve replacement (TAVR). Little information is available about the time course of conduction recovery in these patients and if any features predict early recovery of conduction.

    Methods: A retrospective review was performed of patients who underwent TAVR with balloon and self-expanding valves who required PPMs for HD-AVB. Read More

    Arrhythmia and Clinical Cardiac Findings in Children With Anderson-Fabry Disease.
    Am J Cardiol 2017 Jul 27;120(2):251-255. Epub 2017 Apr 27.
    Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Electronic address:
    Anderson-Fabry Disease (AFD) is a lysosomal storage disorder that results in progressive cardiovascular hypertrophy, scarring, and arrhythmia burden; yet, the early cardiac phenotype of AFD is still poorly defined. To further characterize early cardiac features in AFD, we evaluated electrocardiographic and clinical findings contained in a local cohort of pediatric AFD patients and arrhythmia data in children enrolled in the Fabry Registry. Twenty-six local patients aged <18 years were identified (average age 9. Read More

    Early-onset Lyme carditis with concurrent disseminated erythema migrans.
    Am J Cardiovasc Dis 2017 15;7(2):53-56. Epub 2017 Apr 15.
    West Virginia University Heart and Vascular InstituteMorgantown, WV, USA.
    Background: Lyme disease is an infection that is estimated to affect over 300,000 people in the United States annually. Typically, it presents with erythema migrans (EM), an annular rash at the site of tick attachment, within 3 to 30 days of inoculation. Untreated patients may progress to early disseminated disease. Read More

    Comparison of effectiveness of right ventricular mid-septal pacing vs. apical pacing: a randomized-controlled trials.
    Eur Heart J Suppl 2016 May 24;18(Suppl F):F12-F18. Epub 2016 May 24.
    Department of Cardiology, First Hospital of Lanzhou University, Lanzhou, Gansu 730000, China.
    The aim of the present study was to compare conventional right ventricular apical pacing (RVAP) with right ventricular mid-septal pacing (RVMSP) in terms of echocardiographic and clinical/biologic features. Ninety-six patients with high-degree atrioventricular block were randomly allocated to RVMSP (n = 50) and RVAP (n = 46). Threshold and impedance, echocardiographic left ventricular ejection fraction, ventricular dyssynchrony features, and distance during a 6-min walk test and Minnesota Living with Heart Failure Questionnaire were determined at 6 and 12 months after pacemaker implantation. Read More

    Discovery of a new mutation in the desmin gene in a young patient with cardiomyopathy and muscular weakness.
    Rom J Morphol Embryol 2017 ;58(1):225-230
    Department of Cardiology, "Prof. Dr. C. C. Iliescu" Institute of Emergency for Cardiovascular Diseases, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;
    A 25-year-old woman with a five years history of syncope, mild left ventricular hypertrophy and moderately enlarged atria, was diagnosed with third degree atrioventricular heart block alternating with atrioventricular heart block 2:1, and received a dual chamber pacemaker. After three years of evolution, she developed atrial fibrillation, marked biatrial enlargement, severely depressed longitudinal myocardial velocities, associated with mild girdle weakness and slight increase in creatine kinase level. The diagnosis of restrictive cardiomyopathy with mild skeletal myopathy imposed the screening for a common etiology. Read More

    Amiodarone-Induced Third Degree Atrioventricular Block and Extreme QT Prolongation Generating Torsade Des Pointes in Paroxysmal Atrial Fibrillation.
    J Atr Fibrillation 2016 Oct-Nov;9(3):1502. Epub 2016 Oct 31.
    Department of Health Sciences's Investigation. Sanatorio Metropolitano. Fernando de la Mora. Paraguay. Cardiology Department, Clinic Hospital, Asunción National University, San Lorenzo, Paraguay.
    Amiodarone is still the most potent antiarrhythmic drug in the prevention of life threatening ventricular arrhythmias and demonstrates a very low incidence of torsade de pointes. An unusual case of an 81-year-old woman who developed serious abnormalities of the conduction system of the heart and torsade des pointes during intravenous infusion of amiodarone for the treatment of paroxysmal atrial fibrillation is described. To the best of our knowledge, this is the first case showing an association of intravenous amiodarone-induced third degree atrioventricular block and extreme QT interval prolongation generating torsade des pointes in a patient with paroxysmal atrial fibrillation who required an implantable cardioverter-defibrillator. Read More

    Atrioventricular block: an unusual complication of Graves' disease.
    BMJ Case Rep 2017 May 3;2017. Epub 2017 May 3.
    Evelina London Children's Hospital, London, UK.
    We report the case of a 10-year-old girl treated with atenolol and carbimazole for tachycardia and hypertension associated with Graves' disease who developed symptomatic 2:1 heart block. 2:1 heart block resolved following cessation of atenolol, reduction in carbimazole dose and treatment of suspected tonsillitis. First-degree atrioventricular block persisted, but gradually normalised following improvement in thyroid status. Read More

    Heart failure in patients with arrhythmogenic right ventricular cardiomyopathy: What are the risk factors?
    Int J Cardiol 2017 Aug 21;241:288-294. Epub 2017 Apr 21.
    Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
    Background: We previously demonstrated that heart failure (HF) was one of the major causes of death in arrhythmogenic right ventricular cardiomyopathy (ARVC). The purpose of this study was to elucidate the clinical impact and risk factors of HF in patients with ARVC.

    Methods And Results: We evaluated cardiac adverse outcomes including HF in 113 consecutive patients with ARVC (85 men, mean age: 44±15years). Read More

    Fatal cardiac glycoside poisoning due to mistaking foxglove for comfrey.
    Clin Toxicol (Phila) 2017 Aug 2;55(7):670-673. Epub 2017 May 2.
    b Department of Emergency Medicine , Chang Gung Memorial Hospital, Linkou Branch , Taoyuan , Taiwan.
    Context: Accidental ingestion of foxglove (Digitalis purpurea) can cause significant cardiac toxicity. We report a patient who ingested foxglove mistaking it for comfrey and developed refractory ventricular arrhythmias. The patient died despite treatment with digoxin-specific antibody fragments (DSFab) and veno-arterial extracorporeal membrane oxygenation (VA-ECMO). Read More

    Clinical characteristics associated with bradycardia and asystole in patients with syncope undergoing long-term electrocardiographic monitoring with implantable loop recorder.
    Wien Klin Wochenschr 2017 Jul 27;129(13-14):451-457. Epub 2017 Apr 27.
    Cardiology Clinic, Safarik University, VUSCH, Ondavská 8, 04001, Kosice, Slovakia.
    Background: The aim of this retrospective single center cohort study was to assess the occurrence of bradycardia during implantable loop recorder (ILR) monitoring in patients with unexplained syncope and negative conventional testing and to identify clinical predictors of bradycardia and pacemaker implantation.

    Methods: An ILR was implanted in 112 patients (31 men, 81 women, mean age 64 ±13 years) with syncope which was not explained after conventional diagnostic work-up. Clinical variables were compared between patients with and without pacemaker implantation. Read More

    Association of Non-alcoholic Fatty Liver Disease with Conduction Defects on Electrocardiogram.
    Cureus 2017 Mar 21;9(3):e1107. Epub 2017 Mar 21.
    GME Internal Medicine, Orange Park Medical Center.
    Background: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of liver disease in developed countries. The association of NAFLD with conduction defects is unknown. The aim of our study was to find whether an association exists between conduction defects and NAFLD. Read More

    [Reversible first-degree atrioventricular block due to hyperthyroidism].
    Turk Kardiyol Dern Ars 2017 Apr;45(3):275-277
    Department of Cardiology, TOBB ETU Hospital, Ankara, Turkey.
    Hyperthyroidism often causes tachyarrhythmia. Reversible atrioventricular block caused by hyperthyroidism is rare occurrence. Presently described is a case of atrioventricular block due to hyperthyroidism and recovery after antithyroid treatment. Read More

    Ivabradine vs metoprolol in patients with acute inferior wall myocardial infarction-"Expanding arena for ivabradine".
    Cardiovasc Ther 2017 Aug;35(4)
    Escorts Heart Hospital, New Delhi, India.
    Background: Atrioventricular (AV) blocks are of concern with the use of beta blockers in inferior wall myocardial infarction (MI). Ivabradine lowers heart rate with a lesser risk of AV blocks.

    Objectives: To compare ivabradine with metoprolol in acute inferior wall MI in terms of feasibility, tolerability, and efficacy. Read More

    Adenosine for postoperative analgesia: A systematic review and meta-analysis.
    PLoS One 2017 23;12(3):e0173518. Epub 2017 Mar 23.
    Department of Anesthesiology, Chinese PLA General Hospital, Beijing, China.
    Purpose: Perioperative infusion of adenosine has been suggested to reduce the requirement for inhalation anesthetics, without causing serious adverse effects in humans. We conducted a meta-analysis of randomized controlled trials evaluating the effect of adenosine on postoperative analgesia.

    Methods: We retrieved articles in computerized searches of Scopus, Web of Science, PubMed, EMBASE, and Cochrane Library databases, up to July 2016. Read More

    Ticagrelor Associated Heart Block: The Need for Close and Continued Monitoring.
    Case Rep Cardiol 2017 26;2017:5074891. Epub 2017 Jan 26.
    Drexel University College of Medicine, Philadelphia, PA, USA; Easton Hospital, PA, USA.
    Ticagrelor is an antiplatelet agent prescribed to prevent the development of adverse cardiac events after acute coronary syndrome (ACS). According to the PLATO trial, ticagrelor is associated with ventricular pauses in the first week of treatment; however, these episodes were felt to be asymptomatic and nonfatal to the patient. We present a case of ticagrelor related second-degree type II heart block causing severe dizziness and diaphoresis that resolved after discontinuation of the medication. Read More

    Cervical plexus anesthesia versus general anesthesia for anterior cervical discectomy and fusion surgery: A randomized clinical trial.
    Medicine (Baltimore) 2017 Feb;96(7):e6119
    aDepartment of Spine Surgery bFinancial Statistics Office, The Third Hospital of HeBei Medical University cThe Orthopaedic Department From First Hospital of Shijiazhuang, Shijiazhuang, China.
    Both general anesthesia (GA) and cervical plexus anesthesia (CPA) can be used for anterior cervical discectomy and fusion (ACDF) surgery. The aim of this study was to evaluate the influence of anesthetic techniques on perioperative mortality and morbidity in patients undergoing cervical surgery.From January 2008 to December 2015, 356 patients who underwent 1-level ACDF for cervical spinal myelopathy were prospectively reviewed. Read More

    Electrocardiographic assessments and cardiac events after fingolimod first dose - a comprehensive monitoring study.
    BMC Neurol 2017 Jan 18;17(1):11. Epub 2017 Jan 18.
    Charité Universitaetsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, Berlin, 13353, Germany.
    Background: First dose observation for cardiac effects is required for fingolimod, but recommendations on the extent vary. This study aims to assess cardiac safety of fingolimod first dose. Individual bradyarrhythmic episodes were evaluated to assess the relevance of continuous electrocardiogram (ECG) monitoring. Read More

    Prevalence and characterization of coronary artery disease in patients with symptomatic bradyarrhythmias requiring pacemaker implantation.
    Indian Heart J 2016 Dec 29;68 Suppl 3:S21-S25. Epub 2016 Jun 29.
    Department of Cardiology, SKIMS, Srinagar, India. Electronic address:
    Background: This study was conducted to assess the prevalence and characterization of CAD in high risk patients requiring pacemaker implantation for symptomatic bradyarrhythmias.

    Methods: This study included 100 patients with symptomatic sinus node dysfunction or atrioventricular block, who were at high risk of CAD or had previously documented atherosclerotic vascular disease (ASCVD). Coronary angiography was performed before pacemaker implantation. Read More

    Early safety and efficacy of fingolimod treatment in Denmark.
    Acta Neurol Scand 2017 Jan 8;135(1):129-133. Epub 2016 Mar 8.
    Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
    Background: Initiation of fingolimod treatment is associated with a transient decrease of heart rate, and atrioventricular (AV) conduction block may occur.

    Objective: To evaluate the therapeutic effect and safety of fingolimod treatment in MS patients in Denmark with focus on cardiac and pulmonary side effects at treatment onset.

    Materials & Methods: We analysed data from the first 496 fingolimod-treated Danish patients, observed for at least 3 months. Read More

    Assessment Of Sinoatrial Node Function In Patients With Persistent And Long-Standing Persistent Forms Of Atrial Fibrillation After Maze III Procedure Combined With Mitral Valve operation.
    J Atr Fibrillation 2016 Jun-Jul;9(1):1408. Epub 2016 Jun 30.
    A.N. Bakoulev Scientific Center for Cardiovascular Surgery.
    Research Objective: Assessment of sinoatrial node function after Maze III procedure combined with a mitral valve operation.

    Methods: 100 patients were included in the research with persistent and long-standing persistent forms of atrial fibrillation (AF) and need of operative treatment concerning valve disease. The following preoperative preparation methods were executed to all patients: Electrocardiogram in 12 standard assignments;Two-dimensional echocardiographic with assessment of systolic and diastolic functions of the left ventricle, size of the left atrium and grade of valve disease;Transesophageal echocardiography for exclusion of blood clots in the left atrium and left atrial appendage;Coronary angiography for exclusion of coronary heart disease;Computer tomography for examination of cardiac chambers and anatomic characteristics of pulmonary veins. Read More

    Lyme Carditis: An Interesting Trip to Third-Degree Heart Block and Back.
    Case Rep Cardiol 2016 6;2016:5454160. Epub 2016 Nov 6.
    Department of Medicine, Memorial Hospital of Rhode Island, Alpert Medical School, Brown University, Pawtucket, RI, USA.
    Carditis is an uncommon presentation of the early disseminated phase of Lyme disease. We present the case of a young female who presented with erythema migrans and was found to have first-degree heart block which progressed to complete heart block within hours. After receiving ceftriaxone, there was complete resolution of the heart block in sequential fashion. Read More

    Steroid pulse therapy was effective for cardiac sarcoidosis with ventricular tachycardia and systolic dysfunction.
    ESC Heart Fail 2016 Dec 4;3(4):288-292. Epub 2016 Jul 4.
    Division of Cardiology and Cardiac Catheterization Laboratories Showa University Northern Yokohama Hospital Yokohama Japan.
    A 32-year-old man presented with palpitation. He was diagnosed with pulmonary sarcoidosis by lung biopsy. The electrocardiogram showed first-degree atrioventricular block and complete right bundle branch block (CRBBB). Read More

    Long-term effects of frequent maximal breath-holding on the cardiac health of elite freedivers.
    Scand J Med Sci Sports 2016 Nov 22;26(11):1283-1286. Epub 2015 Dec 22.
    Department of Cardiology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
    Cardiac arrhythmias are commonly reported in freedivers during maximal voluntary breath-holds, but their influence on the cardiological status and their long-term effects on the cardiac health of these athletes have not been investigated. Here we present the results of a study on 32 healthy young men (mean age 32.6 ± 1. Read More

    Sustained clinical benefit of cardiac resynchronization therapy in non-LBBB patients with prolonged PR-interval: MADIT-CRT long-term follow-up.
    Clin Res Cardiol 2016 Nov 18;105(11):944-952. Epub 2016 Jun 18.
    Heart Research Follow-Up Program, University of Rochester Medical Center, Rochester, NY, USA.
    Objective: In MADIT-CRT, patients with non-LBBB (right bundle branch block or nonspecific ventricular conduction delay) and a prolonged PR-interval derived significant clinical benefit from cardiac resynchronization therapy with defibrillator (CRT-D) compared to an implantable cardioverter defibrillator (ICD)-only. We aimed to study the long-term outcome of non-LBBB patients by baseline PR-interval with CRT-D versus ICD-only.

    Methods: Non-LBBB patients (n = 534) were dichotomized based on baseline PR-interval: normal PR (PR < 230 ms), and markedly prolonged PR (PR ≥ 230 ms). Read More

    Cardiovascular magnetic resonance features of mechanical dyssynchrony in patients with left bundle branch block.
    Int J Cardiovasc Imaging 2016 Sep 15;32(9):1427-1438. Epub 2016 Jun 15.
    Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, 660 First Avenue, Room 411, New York, NY, USA.
    Patients with left bundle branch block (LBBB) can exhibit mechanical dyssynchrony which may contribute to heart failure; such patients may benefit from cardiac resynchronization treatment (CRT). While cardiac magnetic resonance imaging (CMR) has become a common part of heart failure work-up, CMR features of mechanical dyssynchrony in patients with LBBB have not been well characterized. This study aims to investigate the potential of CMR to characterize mechanical features of LBBB. Read More

    Brugada syndrome in the young: an assessment of risk factors predicting future events.
    Europace 2016 Oct 13. Epub 2016 Oct 13.
    Heart Rhythm Management Centre, UZ Brussel-VUB, Brussels, Belgium.
    Aims: To investigate the clinical characteristics, prognoses, and presence of risk factors in young patients with Brugada syndrome (BS).

    Methods And Results: A consecutive cohort of 128 young BS patients (≤25 years old at diagnosis) was analysed. Eighty-eight patients (69%) were asymptomatic, whereas 40 (31%) presented with clinical manifestations of BS. Read More

    Conduction Disorders After Sutureless Aortic Valve Replacement.
    Ann Thorac Surg 2017 Apr 4;103(4):1254-1260. Epub 2016 Oct 4.
    Division of Cardiac Surgery, Montreal Heart Institute, Montreal, Quebec, Canada. Electronic address:
    Background: Sutureless self-expandable aortic bioprostheses rely on radial forces for stabilization, raising concern that these devices may increase the risk of postoperative conduction disease. The purpose of this study was to determine the incidence of conduction disorders after sutureless aortic valve replacement (AVR) with the Perceval S (Sorin Group, Saluggia, Italy) bioprosthesis.

    Methods: Between June 2011 and March 2013, 108 consecutive patients underwent sutureless AVR with the Perceval S prosthesis. Read More

    [Cardiac permanent pacemaker after transcatheter aortic valve implantation: A predictive and scientific review].
    Ann Cardiol Angeiol (Paris) 2016 Nov 29;65(5):346-351. Epub 2016 Sep 29.
    Unité de rythmologie et de stimulation cardiaque, hôpital d'Antony, 1, rue Velpeau, 92160 Antony, France. Electronic address:
    Transcatheter aortic valve implantation (TAVI) is nowadays a worldwide technique in the field of treating aortic stenosis. One of the main side effects linked to the technique are mostly attached to rhythm disturbances, such as atrioventricular (AV) and intraventricular blocks. Consequently, a pacemaker implantation is often required. Read More

    Cardiac Safety Profile of First Dose of Fingolimod for Relapsing-Remitting Multiple Sclerosis in Real-World Settings: Data from a German Prospective Multi-Center Observational Study.
    Neurol Ther 2016 Dec 13;5(2):193-201. Epub 2016 Sep 13.
    Novartis Pharma GmbH, Nuremberg, Germany.
    Introduction: Fingolimod was the first oral therapy approved for the treatment of relapsing-remitting multiple sclerosis (RRMS). Due to its action on cardiac sphingosine 1-phosphate receptors, fingolimod is leading to a transient decrease in heart rate (HR) and the occurrence of rare and asymptomatic self-limited atrioventricular (AV) blocks. This German non-interventional clinical study aimed to assess the cardiac safety profile in RRMS patients during at least 6 h after the initial treatment or restart after interruption of fingolimod in real-world settings. Read More

    Complete Atrioventricular Block Complicating Mitral Infective Endocarditis Caused by Streptococcus Agalactiae.
    Am J Case Rep 2016 Sep 8;17:650-4. Epub 2016 Sep 8.
    Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
    BACKGROUND Infective endocarditis (IE) involving the mitral valve can but rarely lead to complete atrioventricular block (CAVB). CASE REPORT A 74-year-old man with a history of infective endocarditis caused by Streptococcus gordonii (S. gordonii) presented to our emergency room with fever and loss of appetite, which had lasted for 5 days. Read More

    Incidence and predictors of new-onset atrioventricular block requiring pacemaker implantation after sutureless aortic valve replacement.
    Interact Cardiovasc Thorac Surg 2016 Dec 29;23(6):861-868. Epub 2016 Aug 29.
    Department of Cardiology, Heart Institute-Hospital Germans Trias i Pujol, Badalona, Spain.
    Objectives: In high-risk patients with severe aortic stenosis, aortic valve replacement (AVR) with a sutureless Perceval prosthesis (SU-AVR) can be performed instead of conventional AVR or transcatheter aortic valve implantation. Little data are available regarding postoperative conduction disorders after SU-AVR. We aimed to determine the incidence and predictors of new-onset complete atrioventricular block (NO-AVB) requiring permanent cardiac stimulation following SU-AVR. Read More

    Complete heart block in pregnancy: case report, analysis, and review of anesthetic management.
    J Clin Anesth 2016 Sep 27;33:58-61. Epub 2016 Apr 27.
    Department of Anesthesiology, University of Miami Miller School of Medicine, C-300, 1611 NW 12 Ave, Miami, FL 33136 USA.
    Maternal complete heart block can pose significant challenges for the anesthesiologist in the antepartum, peripartum, and postpartum periods. Some patients may present for the first time in the puerperium with dizziness, weakness, syncope, or congestive heart failure as a result of the additional hemodynamic burden that accompanies pregnancy. Although there is an increase in permanent pacemaker placement in young symptomatic patients before pregnancy, prophylactic placement of pacemakers in asymptomatic parturients is not always indicated. Read More

    Identification of discrete epitopes of Ro52p200 and association with fetal cardiac conduction system manifestations in a rodent model.
    Clin Exp Immunol 2016 Dec 13;186(3):284-291. Epub 2016 Sep 13.
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
    Congenital heart block (CHB) is a potentially lethal condition characterized by a third-degree atrioventricular block (AVB). Despite anti-Ro52 antibodies being detected in nearly 90% of mothers of affected children, CHB occurs in only 1-2% of anti-Ro/Sjögren's-syndrome-related antigen A (SSA) autoantibody-positive pregnancies. Maternal antibodies have been suggested to bind molecules crucial to fetal cardiac function; however, it remains unknown whether a single antibody profile associates with CHB or whether several specificities and cross-reactive targets exist. Read More

    Atrioventricular block after ASD closure.
    Heart Asia 2016 1;8(2):26-31. Epub 2016 Aug 1.
    Department of Cardiology, Royal Children's Hospital, Heart Research Group, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia; Department of Pediatrics, University of Melbourne, Melbourne, Victoria, Australia.
    Objective: Secundum atrial septal defect (ASD) is a common congenital heart defect. There is limited data on both early and late atrioventricular (AV) block post ASD closure. The aim of this study was to determine the incidence and risk factors of AV block associated with ASD closure. Read More

    Heart failure due to cytomegalovirus myocarditis in immunocompetent young adults: a case report.
    BMC Res Notes 2016 Aug 5;9:391. Epub 2016 Aug 5.
    Section of Human Pathology, Division of Tropical Diseases, Department of Infectious Diseases, Universidade Federal do Pará, 92 Generalíssimo Deodoro avenue, 66055-240, Umarizal, PA, Brazil.
    Background: Cardiac complications constitute a rare clinical manifestation of cytomegalovirus (CMV) infection. This virus is usually asymptomatic in immunocompetent individuals. We report a case of myocarditis and cardiac insufficiency due to primary CMV infection. Read More

    [Anesthetic Management of a Patient who Developed Intraoperative Paroxysmal Supraventricular Tachycardia with Pulseless Electric Activity].
    Masui 2016 Jun;65(6):636-9
    A 75-year-old woman was scheduled to undergo an ileus operation under general combined with epidural anesthesia. Preoperative electrocardiogram (ECG) showed first-degree atrioventricular block. The patient received no preoperative antiarrhythmic medication. Read More

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