1,693 results match your criteria Heart Block First Degree


Reversible high-grade atrioventricular block with septal myocardial edema in Lyme carditis.

Herzschrittmacherther Elektrophysiol 2022 Jun 23. Epub 2022 Jun 23.

Clinic of Radiology and Nuclear Medicine, Sophien- und Hufeland-Klinikum Weimar, Weimar, Germany.

A 34-year-old road builder was admitted to the authors' emergency department due to progressive dyspnoea that had been present for 6 days. The patient had a history of excessive smoking (60 cigarettes/day). The medical history was otherwise unremarkable. Read More

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Effectiveness of methotrexate as a second-line treatment for cardiac sarcoidosis assessed via F-FDG PET: a case report.

Eur Heart J Case Rep 2022 Jun 31;6(6):ytac226. Epub 2022 May 31.

Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Background: Although methotrexate has been widely used as a second-line therapy for cardiac sarcoidosis (CS), it is not clear if it has a direct anti-inflammatory effect.

Case Summary: A 65-year-old man presented to our hospital with symptomatic ventricular tachycardia (VT). After cardioversion, electrocardiography showed a first-degree atrioventricular block with a right bundle branch block, and transthoracic echocardiography revealed left ventricular dilatation. Read More

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Reversal of Fetal Heart Block in Antibody-Positive Mother After Hydroxychloroquine and Dexamethasone.

Pediatr Cardiol 2022 Jun 14. Epub 2022 Jun 14.

Division of Pediatric Cardiology, Department of Pediatrics, University of Texas Southwestern Medical Center, 1935 Medical District Dr, Dallas, TX, 75235, USA.

Maternal autoantibody-related complete heart block in the fetus is considered irreversible. During prenatal care for a 25-year-old nulliparous Hispanic woman with newly diagnosed nephrotic-range proteinuria and positive anti-nuclear antigen antibody, complete fetal heart block with a ventricular rate of 60 beats per minute was detected on a fetal echocardiogram at 28-week gestation. A small pericardial effusion and ascites were noted consistent with fetal hydrops. Read More

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A Case of Lyme Carditis With Variable Heart Block Successfully Treated With Oral Doxycycline.

Cureus 2022 May 4;14(5):e24729. Epub 2022 May 4.

Infectious Disease, Keesler Medical Center, Biloxi, USA.

A 39-year-old male without significant past medical history presented with three weeks of worsening fatigue, migratory arthralgia, rash, and unilateral facial weakness after spending three months in Vermont. Serology showed positive Lyme titers 1:64 for both IgM and IgG. EKG on presentation showed a P-R interval of 384 ms, and the patient was admitted for concern of Lyme carditis. Read More

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Vagally Associated Second Degree Atrio-Ventricular Block in a Dog with Severe Azotemia and Evidence of Sympathetic Overdrive.

Vet Sci 2022 May 5;9(5). Epub 2022 May 5.

Clinics Department, Faculty of Veterinary Medicine, Iasi University of Life Sciences "Ion Ionescu de la Brad", Mihail Sadoveanu Alley no. 8, 700489 Iași, Romania.

A 14 years old, 6 kg, mix-breed male dog with severe azotemia due to urinary bladder herniation was presented to our Veterinary Teaching Hospital (VTH). Electrocardiography revealed normal heart rate of 100 bpm, evidence of sinus respiratory arrhythmia (SRA) and frequent second degree atrio-ventricular block following peak inspiratory phase suggestive of vagally-induced atrio-ventricular conduction delay. Echocardiographic examination showed mild mitral regurgitation without any other cardiac changes, and systolic (SAP) and diastolic (DAP) blood pressure values were 185/90 mmHg (SAP/DAP). Read More

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A community-based study on electrocardiographic abnormalities of adult population from South India - Findings from a cross sectional survey.

Indian Heart J 2022 May-Jun;74(3):187-193. Epub 2022 May 13.

Achutha Menon Centre for Health Science Studies, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum Medical College, P.O., Thiruvananthapuram, Kerala, India. Electronic address:

Background: There are no data on electrocardiographic (ECG) findings from general population of Indian subcontinent. We analyzed ECG abnormalities of in adults as part of a community survey of prevalence of coronary artery disease and risk factors from South India.

Methods And Results: In this cross-sectional study of men and women between the ages 20 to 79 years, ECGs recorded digitally were analyzed using the Minnesota code. Read More

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Fetal cardiac dysfunction in pregnancies affected by intrahepatic cholestasis of pregnancy: A cohort study.

J Obstet Gynaecol Res 2022 May 12. Epub 2022 May 12.

Fetal Medicine Unit, Department of Obstetrics and Gynecology Hospital Clínico de la Universidad de Chile, Santiago de Chile.

Aim: To analyze the presence of fetal myocardial dysfunction in intrahepatic cholestasis of pregnancy (ICP) at diagnosis.

Methods: This prospective cohort study included 49 pregnant participants with ICP at diagnosis and 49 nonaffected controls from a single public hospital. ICP was diagnosed based on clinical symptoms after excluding other causes of pruritus and presence of autoimmune diseases. Read More

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Familial Recurrence Patterns in Congenitally Corrected Transposition of the Great Arteries: An International Study.

Circ Genom Precis Med 2022 Jun 12;15(3):e003464. Epub 2022 May 12.

Department of Pediatric Cardiology, CHRU Lille, France (A.H.).

Background: Congenitally corrected transposition of the great arteries (ccTGA) is a rare disease of unknown cause. We aimed to better understand familial recurrence patterns.

Methods: An international, multicentre, retrospective cohort study was conducted in 29 tertiary hospitals in 6 countries between 1990 and 2018, entailing investigation of 1043 unrelated ccTGA probands. Read More

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First-degree atrioventricular block in 14-year-old child due to Lyme disease.

J Infect Dev Ctries 2022 04 30;16(4):726-728. Epub 2022 Apr 30.

Department of Propaedeutic Pediatrics and Medical Genetics, Danylo Halytsky Lviv National Medical University, Communal Noncommercial Enterprise of Lviv Regional Council Lviv Regional Children's Clinical Hospital "Ohmatdyt", Lviv, Ukraine.

Lyme disease is an infectious disease caused by bacteria of the Borrelia burgdorferi sensu lato (Bbsl) complex and is characterized by predominant lesions of the skin, cardiovascular system, nervous system and musculoskeletal system. We have described a clinical case of first-degree atrioventricular block in a 14-year-old boy caused by Lyme borreliosis. The disease started with the manifestations of cardiovascular system involvement. Read More

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Hemodynamic rounds and clinical pathology correlation: Evaluation of a polycythemic patient guided by imaging, hemodynamics, and endomyocardial biopsy.

Ann Pediatr Cardiol 2021 Oct-Dec;14(4):516-520. Epub 2022 Mar 25.

Department of Pediatric Cardiology, Madras Medical Mission, Institute of Cardio Vascular Diseases, Chennai, Tamil Nadu, India.

A 32-year-old male with symptomatic polycythemia was investigated by hematologist for myeloproliferative malignancies and underwent five therapeutic phlebotomies. The identification of hypoxia on pulse oximetry later led to pulmonology evaluation that showed normal lung function tests as well as normal lung parenchyma and airways on advanced imaging. The absence of murmurs and significant precordial findings, normal chest X-ray, and unremarkable findings in electrocardiogram apart from first-degree heart block delayed the cardiac referral. Read More

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Rare and potential pathogenic mutations of LMNA and LAMA4 associated with familial arrhythmogenic right ventricular cardiomyopathy/dysplasia with right ventricular heart failure, cerebral thromboembolism and hereditary electrocardiogram abnormality.

Orphanet J Rare Dis 2022 05 7;17(1):183. Epub 2022 May 7.

The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, 523710, Guangdong Province, China.

Background: Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is associated with ventricular arrhythmia, heart failure (HF), and sudden death. Thromboembolism is also an important and serious complication of ARVC/D. However, the etiology of ARVC/D and thromboembolism and their association with genetic mutations are unclear. Read More

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Impact of atrial septal pacing in left ventricular-only pacing in patients with a first-degree atrioventricular block: A case series.

HeartRhythm Case Rep 2022 Mar 9;8(3):187-190. Epub 2021 Dec 9.

Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Centre, Osaka, Japan.

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Acute echocardiographic and hemodynamic response to his-bundle pacing in patients with first-degree atrioventricular block.

Ann Noninvasive Electrocardiol 2022 Apr 21:e12954. Epub 2022 Apr 21.

Division of Cardiology, Department of Medicine, Duke University, Durham, North Carolina, USA.

Background: Atrial pacing and right ventricular (RV) pacing are both associated with adverse outcomes among patients with first-degree atrioventricular block (1°AVB). His-bundle pacing (HBP) provides physiological activation of the ventricle and may be able to improve both atrioventricular (AV) and inter-ventricular synchrony in 1°AVB patients. This study evaluates the acute echocardiographic and hemodynamic effects of atrial, atrial-His-bundle sequential (AH), and atrial-ventricular (AV) sequential pacing in 1°AVB patients. Read More

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A case report of a novel mutation in lamin A/C gene related with risk of sudden death.

Eur Heart J Case Rep 2022 Apr 22;6(4):ytac128. Epub 2022 Mar 22.

Universidad de los Andes, Faculty of Medicine, Carrera 1 #18a-12, Bogotá 111711, Colombia.

Background: Lamin A/C-associated heart disease is a group of clinical entities characterized by a mutation in the gene. Multiple cardiac phenotypes have been described, including a higher risk of sudden death.

Case Summary: A 23-year-old asymptomatic patient with an extensive history of heart disease in the family consulted the clinic. Read More

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A critical review of ozanimod for the treatment of adults with moderately to severely active ulcerative colitis.

Expert Rev Gastroenterol Hepatol 2022 May;16(5):411-423

Division of Gastroenterology and Hepatology, Northwestern University-Feinberg School of Medicine, Chicago, Illinois, USA.

Introduction: Ozanimod is a sphingosine-1-phosphate (S1P) modulator that inhibits lymphocyte trafficking from lymph nodes to the circulation. It is approved by the US Food and Drug Administration (FDA) for the treatment of relapsing multiple sclerosis and most recently for the management of moderate-severe ulcerative colitis (UC).

Areas Covered: Here we review the status of drugs approved for moderate-severe UC, the unmet needs in the management of UC, proposed mechanisms of action of S1P modulators, clinical data regarding ozanimod in UC, and emerging S1P modulators being evaluated in inflammatory bowel disease. Read More

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Prognostic significance of first-degree atrioventricular block in a large Asian population: a prospective cohort study.

BMJ Open 2022 04 4;12(4):e062005. Epub 2022 Apr 4.

Department of Cardiovascular Medicine, The First Hospital of China Medical University, Shenyang, China

Objective: To investigate the prognostic significance of first-degree atrioventricular block (AVB) in Asian populations.

Design And Setting: Participants (N=9634) from the Northeast China Rural Cardiovascular Health Study were included. The first-degree AVB was defined as PR (from the beginning of the P wave to the beginning of the QRS complex on an electrocardiogram) interval >200 ms, and primary composite outcome (all events) included new onset cardiovascular disease (CVD) and mortality. Read More

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Prediction of Pacemaker Requirement in Patients With Unexplained Syncope: The DROP Score.

Heart Lung Circ 2022 Jul 31;31(7):999-1005. Epub 2022 Mar 31.

Department of Cardiology, Alfred Health, Melbourne, Vic, Australia; Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Vic, Australia; The Baker Heart and Diabetes Institute, Melbourne, Vic, Australia; Department of Cardiology, Western Health, Melbourne, Vic, Australia; Department of Cardiology, Cabrini Health, Melbourne, Vic, Australia. Electronic address:

Background: Implantable loop recorders (ILR) are increasingly utilised in the evaluation of unexplained syncope. However, they are expensive and do not protect against future syncope.

Objectives: To compare patients requiring permanent pacemaker (PPM) implantation during ILR follow-up with those without abnormalities detected on ILR in order to identify potential predictors of benefit from upfront pacing. Read More

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Heart Block as a Rare Complication of Tricuspid Valve Endocarditis: Awareness is the Key.

Cureus 2022 Feb 16;14(2):e22269. Epub 2022 Feb 16.

Internal Medicine, Health Corporation of America-University of Central Florida (HCA-UCF) Consortium, Ocala, USA.

Infective endocarditis (IE) occurs when bacterial or fungal pathogens enter the blood and attach to the endocardium. Right-sided endocarditis is usually associated with intravenous drug use (IVDU), intracardiac devices, and central venous catheters. There is more data published about left-side endocarditis when compared to right-sided endocarditis. Read More

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February 2022

Echocardiography fails to detect an extensive aortic root abscess in a patient with infective endocarditis: a case report.

Eur Heart J Case Rep 2022 Feb 3;6(2):ytac032. Epub 2022 Feb 3.

Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT, USA.

Background: Echocardiography plays a central role in the diagnosis of infective endocarditis (IE). In recent years, additional imaging techniques have begun to challenge the conventional approach. We present a case where the use of transthoracic/transoesophageal echocardiography (TTE/TOE) in suspected IE failed to identify an extensive periannular abscess, later identified by F-flurodeoxyglucose-positron emission tomography (FDG-PET), requiring urgent intervention. Read More

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February 2022

Case Report: Biventricular Noncompaction Cardiomyopathy With Pulmonary Stenosis and Bradycardia in a Fetus With KCNH2 Mutation.

Front Genet 2022 24;13:821226. Epub 2022 Feb 24.

Department of Echocardiography, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Left ventricular noncompaction (LVNC) is a rare cardiomyopathy, long QT syndrome (LQTS) is a rare ion channel disease, and simultaneous occurrence of both is even rarer. Further clinical reports and studies are needed to identify the association between LVNC and LQTS and the underlying mechanism. A 26-year-old primigravida was referred at 25 weeks gestation for prenatal echocardiography due to fetal bradycardia detected during the routine ultrasound examination. Read More

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February 2022

Familial risk of atrioventricular block in first-degree relatives.

Heart 2022 Mar 4. Epub 2022 Mar 4.

Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark

Objective: Rare cases of genetically inherited atrioventricular block (AVB) have been reported; however, the heredity of AVB remains unknown. We aimed to assess the heredity of AVB.

Design, Setting And Participants: Using data from the Danish Civil Registration Registry, we established a nationwide cohort of individuals with parental links. Read More

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Multilobulated Sinus of Valsalva Aneurysm Dissecting into the Interventricular Septum (DAIS) and Rupturing into Left Ventricle: A Case Report.

Eur Heart J Case Rep 2022 Feb 7;6(2):ytac019. Epub 2022 Feb 7.

Department of Radiodiagnosis, Post Graduate Institute of Medical Education & Research, Sector 12, Chandigarh 160012, India.

Background: Dissecting aneurysm of sinus of Valsalva (SOV) into the interventricular septum is a rare entity. Multilobulated form of dissection rupturing into the left ventricle (LV) has never been reported in the literature.

Case Summary: A 52-year-old male presented with dyspnoea and palpitation with wide pulse pressure and peripheral signs of distal run-off and a continuous murmur along the left parasternal area. Read More

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February 2022

Genotype-Phenotype Correlation in Familial Mutation Dilated Cardiomyopathy.

Genes (Basel) 2022 02 17;13(2). Epub 2022 Feb 17.

Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.

We report the case of a 22-year-old male who visited a cardiologist after the first episode of atrial fibrillation (AF). Echocardiography and magnetic resonance imaging revealed decreased left ventricular (LV) systolic function with dilated LV. An intermittent second-degree AV (atrioventricular) block was detected during 24 h Holter monitoring. Read More

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February 2022

AV timing in pacemaker patients with first-degree AV block: which is preferable, intrinsic AV conduction or pacing?

Heart Vessels 2022 Feb 8. Epub 2022 Feb 8.

Department of Medicine, Division of Cardiology, Nihon University School of Medicine, 30-1 Ohyaguchi-kamicho, Itabashi-ku, Tokyo, 173-8610, Japan.

Some patients with pacemakers present with first-degree atrioventricular (AV) block. To avoid right ventricular (RV) pacing, preserving intrinsic AV conduction as much as possible is recommended. However, there is no clear cutoff AV interval to determine whether intrinsic AV conduction should be preserved or RV pacing should be delivered. Read More

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February 2022

Lyme carditis manifesting with sinoatrial exit block: a case report.

Eur Heart J Case Rep 2022 Jan 18;6(1):ytac022. Epub 2022 Jan 18.

Department for Cardiology II: Electrophysiology, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, D-48149 Münster, Germany.

Background: Lyme disease is the most common vector-borne disease in North America and Europe. Infection with the spirochete complex can involve cardiac tissue causing Lyme carditis (LC). Due to the infection of conductive tissue, LC typically presents with varying degrees of atrioventricular conduction block. Read More

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January 2022

Relation of Norwood Shunt Type and Frequency of Arrhythmias at 6 Years (from the Single Ventricle Reconstruction Trial).

Am J Cardiol 2022 04 31;169:107-112. Epub 2022 Jan 31.

Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.

The Norwood procedure with a right ventricular to pulmonary artery shunt (RVPAS) decreases early mortality, but requires a ventriculotomy, possibly increasing risk of ventricular arrhythmias (VAs) compared with the modified Blalock-Taussig shunt (MBTS). The effect of shunt and Fontan type on arrhythmias by 6 years of age in the SVRII (Single Ventricle Reconstruction Extension Study) was assessed. SVRII data collected on 324 patients pre-/post-Fontan and annually at 2 to 6 years included antiarrhythmic medications, electrocardiography (ECG) at Fontan, and Holter/ECG at 6 years. Read More

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Electrocardiographic features and need for pacemaker in cardiac amyloidosis: Analysis of 58 cases.

Med Clin (Barc) 2022 Jan 21. Epub 2022 Jan 21.

Servicio de Cardiología, Hospital Universitario Reina Sofia, Córdoba, España; Instituto Maimónides de Investigación Biomédica de Córdoba, Universidad de Córdoba, Córdoba, España.

Aim: Amyloidosis is a disease in which amyloid fibrils can be deposited in different cardiac structures, and several electrocardiographic abnormalities can be produced by this phenomenon. The objective of this study was to describe the most common basal electrocardiographic alterations in patients diagnosed with cardiac amyloidosis (CA) and to determine if these abnormalities have an impact on the need of pacemaker.

Methods: This retrospective study included patients who had an established diagnosis of CA [light-chain cardiac amyloidosis (LA-CA) or transthyretin cardiac amyloidosis (TTR-CA)] between January 2013 and March 2021. Read More

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January 2022

Transient third-degree atrioventricular block during anesthesia in a cat.

Open Vet J 2021 Oct-Dec;11(4):662-666. Epub 2021 Nov 16.

Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan.

Background: Third-degree atrioventricular block (AVB) is usually permanent, with transient cases being rare. Cats with transient third-degree AVB. It had been not reported in detail. Read More

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Clinical Spectrum of Channelopathy in Children with Primary Electrical Disease and Structurally Normal Hearts.

Genes (Basel) 2021 12 22;13(1). Epub 2021 Dec 22.

Departament of Electrocardiology, National Institute of Cardiology "Ignacio Chávez", Mexico City 14080, Mexico.

Sodium voltage-gated channel α subunit 5 (-mutations may cause an array of arrhythmogenic syndromes most frequently as an autosomal dominant trait, with incomplete penetrance, variable expressivity and male predominance. In the present study, we retrospectively describe a group of Mexican patients with -disease causing variants in whom the onset of symptoms occurred in the pediatric age range. The study included 17 patients with clinical diagnosis of primary electrical disease, at least one pathogenic or likely pathogenic mutation and age of onset <18 years, and all available first- and second-degree relatives. Read More

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December 2021

Outcome of Antibody-Mediated Fetal Heart Disease With Standardized Anti-Inflammatory Transplacental Treatment.

J Am Heart Assoc 2022 02 8;11(3):e023000. Epub 2022 Jan 8.

The Hospital for Sick Children Toronto Ontario Canada.

Background Transplacental fetal treatment of immune-mediated fetal heart disease, including third-degree atrioventricular block (AVB III) and endocardial fibroelastosis, is controversial. Methods and Results To study the impact of routine transplacental fetal treatment, we reviewed 130 consecutive cases, including 108 with AVB III and 22 with other diagnoses (first-degree/second-degree atrioventricular block [n=10]; isolated endocardial fibroelastosis [n=9]; atrial bradycardia [n=3]). Dexamethasone was started at a median of 22. Read More

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February 2022