1,533 results match your criteria Heart Block First Degree


Mitoxantrone in relapsing-remitting and rapidly progressive multiple sclerosis: Ten-year clinical outcomes post-treatment with mitoxantrone.

Mult Scler Relat Disord 2020 Jun 23;44:102330. Epub 2020 Jun 23.

Department of Neurology, Leeds Centre for Neurosciences, Leeds General Infirmary, Leeds, LS1 3EX, United Kingdom.

Background: Mitoxantrone (MTX) has been used as an effective disease modifying treatment (DMT) in multiple sclerosis (MS). Evidence from studies demonstrates benefits of reduced relapse rates, MRI disease activity and disability progression in patients treated with MTX. While effective, MTX use has been limited due to potential adverse effects (AE) ranging from mild to potentially life-threatening AEs such as cardiotoxicity, bone marrow suppression and hematological malignancies. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102330DOI Listing

A Different Breed of Wolf: First Known Case of Wolf-Hirschorn Syndrome with Third-degree Atrioventricular Block Requiring Pacemaker Implantation.

J Innov Card Rhythm Manag 2020 Jun 15;11(6):4147-4150. Epub 2020 Jun 15.

Electrophysiology Section, Bryan Heart Institute, Lincoln, NE, USA.

We describe a case of a 44-year-old male with a history of Wolf-Hirschorn syndrome (WHS) with seizures and mental retardation who was evaluated for what was thought to be a seizure. He was found to be severely bradycardic with a heart rate of 24 bpm. The electrocardiogram revealed third-degree atrioventricular block and he subsequently underwent an uncomplicated single-chamber pacemaker implantation procedure. Read More

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http://dx.doi.org/10.19102/icrm.2020.110601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313625PMC

Risk factors for permanent pacemaker implantation in patients receiving a balloon-expandable transcatheter aortic valve prosthesis.

Heart Vessels 2020 Jun 26. Epub 2020 Jun 26.

Department of Cardiology and Angiology, University Hospital of Tübingen, Tübingen, Germany.

Permanent pacemaker implantation (PPI) is a widely recognized complication associated with TAVI (incidence up to 20%). Smaller registries have identified several variables associated with PPI. The objective was to validate patient- and transcatheter aortic valve implantation (TAVI)-related procedural variables associated with PPI. Read More

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http://dx.doi.org/10.1007/s00380-020-01653-6DOI Listing

Treatment and follow-up of fetuses that developed congenital heart block due to autoantibody in two cases.

J Int Med Res 2020 Jun;48(6):300060520925596

Department of Echocardiography, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Objective: Autoantibody-related congenital heart block (ACHB) is a passively acquired autoimmune disease. This study aimed to examine the pathogenesis, clinical manifestations, and treatment of ACHB.

Method: The clinical data of two fetuses with first-degree ACHB were retrospectively analyzed. Read More

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http://dx.doi.org/10.1177/0300060520925596DOI Listing

Narrow QRS tachycardia in a patient with first degree atrioventricular block: What is the mechanism?

Pacing Clin Electrophysiol 2020 Jun 23. Epub 2020 Jun 23.

Department of Cardiac Electrophysiology and Pacing, Medanta Heart Institute, Medanta The Medicity.

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http://dx.doi.org/10.1111/pace.13993DOI Listing

[PECULIARITIES OF CARBOPNEUMPEROPERITONEUM AT LAPAROSCOPIC OPERATION UNDER CONDITIONS OF RHYTHM DISORDERS AND CONDUCTIVITY OF CARDIAC ACTIVITY].

Georgian Med News 2020 Apr(301):7-13

National Pirogov Memorial Medical University, Vinnytsya, Ukraine.

The aim of the research - to study the effect of carbopneumoperitoneum on the possibility of laparoscopic surgery in patients with cardiac rhythm disorders and conduction disturbances. We conducted analysis of 940 patients who underwent laparoscopic surgery. The patients were divided into two groups. Read More

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POPDC2 a novel susceptibility gene for conduction disorders.

J Mol Cell Cardiol 2020 Jun 11;145:74-83. Epub 2020 Jun 11.

Institute for Physiology and Pathophysiology, Vegetative Physiology and Marburg Center for Mind, Brain and Behavior MCMBB, Philipps-University of Marburg, Marburg, Germany. Electronic address:

Despite recent progress in the understanding of cardiac ion channel function and its role in inherited forms of ventricular arrhythmias, the molecular basis of cardiac conduction disorders often remains unresolved. We aimed to elucidate the genetic background of familial atrioventricular block (AVB) using a whole exome sequencing (WES) approach. In monozygotic twins with a third-degree AVB and in another, unrelated family with first-degree AVB, we identified a heterozygous nonsense mutation in the POPDC2 gene causing a premature stop at position 188 (POPDC2), deleting parts of its cAMP binding-domain. Read More

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http://dx.doi.org/10.1016/j.yjmcc.2020.06.005DOI Listing

Left bundle branch pacing improved heart function in a 10-year-old child after a 3-month follow-up.

Europace 2020 Jun 12. Epub 2020 Jun 12.

Department of Cardiology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, No. 1678 Dongfang Road, Shanghai 200127, China.

Aims: As a physiological pacing strategy, left bundle branch pacing (LBBP) were used to correct left bundle branch block (LBBB), however, there is no relevant report in children. We aimed to evaluate the feasibility of LBBP in children.

Methods And Results: Left bundle branch pacing was performed in a 10-year-old girl with a second-degree atrioventricular and LBBB. Read More

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http://dx.doi.org/10.1093/europace/euaa090DOI Listing

Evaluation of mexiletine effect on conduction delay and bradyarrhythmic complications in patients with myotonic dystrophy type 1 over long-term follow-up.

Heart Rhythm 2020 Jun 7. Epub 2020 Jun 7.

Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padova, Padova, Italy.

Background: Myotonic dystrophy type 1 (DM1) is a multisystemic disorder characterized by progressive cardiac conduction impairment, arrhythmias and sudden death. Mexiletine is a sodium-channel blocker drug used in such patients for the treatment of myotonia, even if definitive proof of its safety over long-term follow-up is lacking OBJECTIVE: To assess the impact of mexiletine for treatment of neurological symptoms on the composite endpoint of significant ECG modification (new onset or worsening of atrioventricular or intraventricular conduction delay) and bradyarrhythmic complications requiring pacemaker implantation (advanced atrioventricular block, symptomatic sinus pause >3 s) METHODS: This retrospective longitudinal study included a series of consecutive patients with genetically confirmed DM1 evaluated in our Neurology and Cardiology Clinic from January 1 2011 to January 1 2020, who received a 200 mg twice daily (BID) dose of mexiletine. Patients with pacemaker, implantable cardioverter defibrillation, or severe conduction abnormality (PQ interval ≥230ms, complete bundle branch block or atrial fibrillation) at enrollment were excluded RESULTS: we included 18 mexiletine-treated patients and 68 mexiletine-free controls. Read More

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http://dx.doi.org/10.1016/j.hrthm.2020.05.043DOI Listing

Clinical predictors of all-cause mortality in patients presenting to specialist heart failure clinic with raised NT-proBNP and no heart failure.

ESC Heart Fail 2020 Jun 4. Epub 2020 Jun 4.

Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK.

Aims: Clinical outcomes for patients suspected of having heart failure (HF) who do not meet the diagnostic criteria of any type of HF by echocardiography remain unknown. The aim of this study was to investigate the clinical predictors of all-cause mortality in patients with suspected HF, a raised N-terminal pro-b-type natriuretic peptide (NTproBNP) and who do not meet the diagnostic criteria of any type of HF by echocardiography.

Methods And Results: Relevant data were taken from the Sheffield HEArt Failure (SHEAF) registry (222349P4). Read More

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http://dx.doi.org/10.1002/ehf2.12742DOI Listing

Effectiveness of Interferon Beta 1a, compared to Interferon Beta 1b and the usual therapeutic regimen to treat adults with moderate to severe COVID-19: structured summary of a study protocol for a randomized controlled trial.

Trials 2020 Jun 3;21(1):473. Epub 2020 Jun 3.

Department of Infectious Diseases, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objectives: We will investigate the effectiveness of Interferon Beta 1a, compared to Interferon Beta 1b and the usual therapeutic regimen in COVID-19 in patients that have tested positive and are moderately to severely ill.

Trial Design: This is a single center, open label, randomized, controlled, parallel group, clinical trial that will be conducted at Loghman Hakim Medical Education Center in conjunction with Shahid Beheshti University of Medical Sciences.

Participants: Sixty COVID-19 confirmed cases (using the RT-PCR test) will be enrolled in the trial between April 9 to April 14 2020. Read More

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http://dx.doi.org/10.1186/s13063-020-04382-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268172PMC

Electrocardiography Interpretation Competency of Medical Interns: Experience from Two Ethiopian Medical Schools.

Emerg Med Int 2020 11;2020:7695638. Epub 2020 May 11.

Department of Emergency Medicine and Critical Care, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Electrocardiography (ECG) is the graphical display of electrical potential differences of an electric field originating in the heart. Interpretation of ECG is a core clinical skill in the department of emergency medicine. The main aim of this survey was to assess competency of ECG interpretation among 2018 graduating class medical students in Addis Ababa University and Haramaya University. Read More

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http://dx.doi.org/10.1155/2020/7695638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238320PMC

Proarrhythmic effects from competitive atrial pacing and potential programming solutions.

Pacing Clin Electrophysiol 2020 May 25. Epub 2020 May 25.

The Section of Cardiac Electrophysiology and Pacing, Department of Cardiovascular Medicine, Heart & Vascular Institute, Cleveland Clinic, Cleveland, Ohio.

Background: Programmed long AV delays and intrinsic long first degree AV block may increase risk for competitive atrial pacing (CAP) in devices without CAP avoidance algorithms.

Methods: Patients identified with CAP-induced mode switch episodes were followed clinically from September 2013 to August 2019. Attempts to avoid CAP included shortening of postventricular atrial refractory period (PVARP) or postventricular atrial blanking period (PVAB), or change to AAI or DDI modes. Read More

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http://dx.doi.org/10.1111/pace.13962DOI Listing

Very late-onset endocarditis complicated by non-significant aortic regurgitation after device closure of perimembranous ventricular septal defect.

Medicine (Baltimore) 2020 May;99(19):e20120

Department of Pediatric Cardiology.

Introduction: Aortic regurgitation (AR) was recognized as a major, but rare complication after device closure for perimembranous ventricular septal defects (PmVSD). Most of them are temporary and non-significant. Infectious endocarditis (IE) is another extremely rare post-procedure complication of PmVSD. Read More

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http://dx.doi.org/10.1097/MD.0000000000020120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220634PMC

Efficacy and cardiorespiratory effects of lumbosacral intrathecal 2% procaine and 2% xylazine with or without sedation in calves undergoing umbilical surgery.

N Z Vet J 2020 May 25:1-8. Epub 2020 May 25.

Department of Clinical Sciences, Surgery and Anaesthesia Unit, Oniris (École nationale vétérinaire, agroalimentaire et de l'alimentation, Nantes-Atlantique), Nantes, France.

To compare the effects of intrathecal anaesthesia using procaine and xylazine, with and without sedation with I/V xylazine and butorphanol, on sedation and cardiorespiratory measures in calves undergoing umbilical surgery. Male dairy calves, aged <3 months, were recruited that had enlargement of the umbilical stalk which was abnormal when palpated. They were assigned to receive either intrathecal injection between the sixth lumbar and first sacral vertebrae of 4 mg/kg of 2% procaine and 0. Read More

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http://dx.doi.org/10.1080/00480169.2020.1754303DOI Listing

Nontransient third-degree heart block and persistent respiratory findings as sequelae of acute occupational exposure to pyrethroids insecticide.

Am J Ind Med 2020 Jul 16;63(7):644-648. Epub 2020 Apr 16.

Occupational & Environmental Medicine of Long Island, Northwell Health and Occupational Medicine, New York, New York.

We present the case of a worker with occupational exposure to a pyrethroid insecticide who acutely developed nontransient third-degree heart block. In 2000, a 57-year-old male truck driver on his delivery route was accidentally exposed to pyrethroid insecticide being sprayed for West Nile virus containment. Both the driver and his vehicle were coated with the spray. Read More

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http://dx.doi.org/10.1002/ajim.23111DOI Listing

Effect of primary PCI on the recovery of atrioventricular block in inferior STEMI patients with late presentation (>12 hours): insights from a single center 10-year experience.

J Investig Med 2020 Jun 25;68(5):1011-1014. Epub 2020 Mar 25.

Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China

There is no definite reperfusion time for inferior ST-elevation myocardial infarction (STEMI) patients presenting later than 12 hours after symptom onset and complicated by newly-developed atrioventricular block (AVB). It is not clear whether the percutaneous coronary intervention (PCI) could facilitate the recovery of AVB in this patient group. We conducted a retrospective study including 52 consecutive inferior STEMI patients with presenting time >12 hours and new onset second or third-degree AVB on admission. Read More

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http://dx.doi.org/10.1136/jim-2019-001255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306870PMC

Cardiac radioablation-A systematic review.

Heart Rhythm 2020 Mar 20. Epub 2020 Mar 20.

Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Cardiovascular Sciences, Amsterdam, The Netherlands. Electronic address:

Failure of drugs and catheter ablation procedures for the treatment of ventricular arrhythmias is still extremely relevant. Recently, stereotactic body radiotherapy has been introduced to treat therapy refractory patients. In this systematic review (International Prospective Register of Systematic Reviews, CRD42019133212), we aimed to summarize electrophysiological and histopathological effects of radioablation in animals, patients, and extracted and perfused hearts. Read More

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http://dx.doi.org/10.1016/j.hrthm.2020.03.013DOI Listing

Risk Prediction Model for Cardiac Implantable Electronic Device Implantation After Transcatheter Aortic Valve Replacement.

JACC Clin Electrophysiol 2020 03 29;6(3):295-303. Epub 2020 Jan 29.

Department of Medicine, Division of Cardiology, Case Western Reserve University, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio. Electronic address:

Objectives: The aim of this study was to develop and validate a risk prediction model for high-grade atrioventricular block requiring cardiac implantable electronic device (CIED) implantation after transcatheter aortic valve replacement (TAVR).

Background: High-grade atrioventricular block requiring CIED remains a significant sequelae following TAVR. Although several pre-operative characteristics have been associated with the risk of post-operative CIED implantation, an accurate and validated risk prediction model is not established yet. Read More

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http://dx.doi.org/10.1016/j.jacep.2019.10.020DOI Listing

A 60-year-old with heart failure symptoms due to 1st degree AV-Block caused by granulomatosis with polyangiitis (Wegener's granulomatosis).

J Cardiol Cases 2020 Mar 4;21(3):114-118. Epub 2019 Dec 4.

Neurology Department, Bundeswehrkrankenhaus Berlin, Berlin, Germany.

Granulomatosis with polyangiitis is a rare systemic inflammatory disorder mainly affecting the small vessels. Cardiac involvement is rare, conduction delay being the most rare one. This case reports on a middle-aged male patient with heart failure symptoms due to a 1st degree atrioventricular block with a marked PR prolongation of 480 ms on electrocardiography (ECG). Read More

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http://dx.doi.org/10.1016/j.jccase.2019.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054659PMC

First-Degree Atrioventricular Block and Hypertrophic Cardiomyopathy: "I Have a Bad Feeling About This".

Authors:
Timothy C Wong

J Am Heart Assoc 2020 Mar 9;9(6):e015911. Epub 2020 Mar 9.

Division of Cardiology Department of Medicine University of Pittsburgh School of Medicine Pittsburgh PA.

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http://dx.doi.org/10.1161/JAHA.120.015911DOI Listing
March 2020
2.882 Impact Factor

Prognostic Implication of First-Degree Atrioventricular Block in Patients With Hypertrophic Cardiomyopathy.

J Am Heart Assoc 2020 Mar 9;9(6):e015064. Epub 2020 Mar 9.

Department of Cardiology Tokyo Women's Medical University Tokyo Japan.

Background The association between first-degree atrioventricular block (AVB) and life-threatening cardiac events in patients with hypertrophic cardiomyopathy (HCM) remains unclear. This study sought to investigate whether presence of first-degree AVB was associated with HCM-related death in patients with HCM. Methods and Results We included 414 patients with HCM (mean age, 51±16 years; 64. Read More

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http://dx.doi.org/10.1161/JAHA.119.015064DOI Listing

Pembrolizumab-Induced Mobitz Type 2 Second-Degree Atrioventricular Block.

Case Rep Cardiol 2020 28;2020:8428210. Epub 2020 Jan 28.

Department of Cardiology, SUNY Upstate Medical University, USA.

Pembrolizumab is a monoclonal antibody directed towards programmed cell death protein 1 (PD-1) and is an antineoplastic drug which has a growing variety of oncologic uses. Pembrolizumab is commonly associated with immune-related adverse events (IRAEs) but is infrequently noted to cause cardiotoxicities such as myocarditis, arrhythmias, and heart failure. The following case report illustrates the clinical course of a 67-year-old female patient with stage IV non-small-cell lung cancer who developed Mobitz type 2 second-degree atrioventricular block three weeks after receiving her first infusion of pembrolizumab. Read More

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http://dx.doi.org/10.1155/2020/8428210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007942PMC
January 2020

Survival of a dog with accidental colchicine overdose.

J Vet Emerg Crit Care (San Antonio) 2020 Jan 28;30(1):74-80. Epub 2019 Dec 28.

Department of Medicine, Veterinary Specialist Services, Underwood, Queensland, Australia.

Objective: To describe the treatment and clinical course of a dog accidentally prescribed 10 times the recommended dose of colchicine (0.3 mg/kg/d instead of 0.03 mg/kg/d). Read More

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http://dx.doi.org/10.1111/vec.12919DOI Listing
January 2020

Non-O-blood types associated with higher risk of high-grade atrioventricular block.

Arch Med Sci Atheroscler Dis 2019 26;4:e243-e247. Epub 2019 Nov 26.

Kartal Koşuyolu Heart and Vascular Disease Research and Training Hospital, Istanbul, Turkey.

Introduction: The non-O phenotype of the ABO genotype has been linked with an increased risk of cardiovascular disease. Atrioventricular (AV) block (AVB) is defined as retardation or cessation in the route of an electrical impulse passing from the atria to the ventricles because of an anatomical or functional disruption in the conduction system. We aimed to interpret the association between blood group status and high-grade atrioventricular block (HAVB). Read More

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http://dx.doi.org/10.5114/amsad.2019.90072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900742PMC
November 2019

The QR-max index, a novel electrocardiographic index for the determination of left ventricular conduction delay and selection of cardiac resynchronization in patients with non-left bundle branch block.

J Interv Card Electrophysiol 2019 Dec 5. Epub 2019 Dec 5.

Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.

Non-left bundle branch block (non-LBBB) remains an uncertain indication for cardiac resynchronization therapy (CRT). Non-LBBB includes right bundle branch block (RBBB) and non-specific LV conduction delay (NSCD), two different electrocardiogram (ECG) patterns which are not generally considered to be associated with LV conduction delay as judged by the invasive assessment of the Q-LV interval. We evaluated whether a novel ECG interval (QR-max index) correlated with the degree of LV conduction delay regardless of the type of non-LBBB ECG pattern, and could, therefore, predict CRT response. Read More

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http://dx.doi.org/10.1007/s10840-019-00671-3DOI Listing
December 2019
1.552 Impact Factor

Complete atrioventricular block due to timolol eye drops: a case report and literature review.

BMC Pharmacol Toxicol 2019 12 2;20(1):73. Epub 2019 Dec 2.

Department of Pharmacology, Louisiana State University Health Sciences Center New Orelans, New Orleans, LA, 70112, USA.

Background: Timolol Maleate is a non-selective beta-adrenergic blocker that is commonly used to treat open-angle glaucoma. Despite its topical administration, ophthalmic timolol enters systemic circulation and produces a systemic beta-adrenergic blockade. We report a case of long-term timolol use that uncovered and worsened an underlying cardiac conduction defect demonstrated as a third degree atrioventricular (AV) block. Read More

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http://dx.doi.org/10.1186/s40360-019-0370-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889336PMC
December 2019

Spontaneous brain arteriovenous malformation rupture with atrioventricular block in a pediatric patient.

Authors:
Matthew Cully

Am J Emerg Med 2020 02 16;38(2):409.e1-409.e3. Epub 2019 Nov 16.

Division of Emergency Medicine, Department of Pediatrics, Nemours Alfred I. duPont Hospital for Children. Wilmington, DE, USA. Electronic address:

This case reports 9 year-old-female with atrioventricular block and seizure. Careful evaluation, including electrocardiogram (ECG) and computerized tomography (CT) revealed a high-grade atrioventricular block and spontaneous brain arteriovenous malformation (AVM) rupture. The patient had complete resolution of her bradycardia and AV block following atropine. Read More

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http://dx.doi.org/10.1016/j.ajem.2019.10.005DOI Listing
February 2020

Surgical treatment results of secondary tunnel-like subaortic stenosis after congenital heart disease operations: A 7-year, single-center experience in 25 patients.

J Card Surg 2020 Feb 25;35(2):335-340. Epub 2019 Nov 25.

Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objective: To summarize the surgical results of secondary tunnel-like subaortic stenosis (STSS) after congenital heart disease (CHD) operations, the pathogenesis of STSS is analyzed and its operative effect and prognosis are evaluated.

Methods: We analyzed clinical data from 25 patients who underwent surgical repair for STSS in Fuwai Hospital from 1 January 2009 to 31 December 2015. There were 17 males and 8 females. Read More

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http://dx.doi.org/10.1111/jocs.14369DOI Listing
February 2020

Long-Term Electrocardiographic Changes and Clinical Outcomes of Transcatheter Aortic Valve Implantation Recipients Without New Postprocedural Conduction Disturbances.

Am J Cardiol 2020 01 15;125(1):107-113. Epub 2019 Oct 15.

Quebec Heart & Lung Institute, Laval University, Quebec City, Quebec, Canada. Electronic address:

The objective of this study was to determine the long-term (>1 year) electrocardiographic (ECG) and clinical outcomes of patients without significant changes in their electrocardiogram after transcatheter aortic valve implantation (TAVI; including patients with pre-existing ECG abnormalities). Among 772 consecutive patients who underwent TAVI in our institution, 397 patients (51%) without new ECG changes were included. TAVI patients were divided into 2 groups according to the presence of pre-existing ECG-conduction disturbances (ECG-CD: 140 patients, non-ECG-CD: 257 patients). Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.09.047DOI Listing
January 2020

Analysis of cardiac monitoring and safety data in patients initiating fingolimod treatment in the home or in clinic.

BMC Neurol 2019 Nov 15;19(1):287. Epub 2019 Nov 15.

State of the Heart Cardiology, Plaza 1, Medical Pkwy. N Suite 103, Dallas, TX, 75234, USA.

Background: Fingolimod (Gilenya®) is approved for relapsing forms of multiple sclerosis in the USA. Owing to transient heart-rate effects when initiating fingolimod, eligible patients undergo precautionary baseline assessment and first-dose observation (FDO) for ≥6 h. Prior to 2014, FDO was undertaken only in clinics. Read More

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http://dx.doi.org/10.1186/s12883-019-1506-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857316PMC
November 2019
2.040 Impact Factor

Lyme Carditis: A Rare Presentation of Sinus Bradycardia Without Any Conduction Defects.

Cureus 2019 Sep 2;11(9):e5554. Epub 2019 Sep 2.

Family Medicine, Hackensack Meridian Health, Ocean Medical Center, Brick, USA.

Lyme carditis is a rare cardiac manifestation of Lyme disease that occurs when bacterial spirochetes infect the pericardium or myocardium triggering an inflammatory response. The most common electrocardiogram (EKG) findings in these patients include atrioventricular (AV) conduction abnormalities (first, second, and third degree heart block). A 56-year-old male with a history of hypothyroidism, from the Northeastern region of the United States, presented to the emergency department with lightheadedness and chest pain. Read More

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http://dx.doi.org/10.7759/cureus.5554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820318PMC
September 2019
1 Read

Role of family history and clinical screening in the identification of families with idiopathic dilated cardiomyopathy in Johannesburg, South Africa.

S Afr Med J 2019 Aug 28;109(9):673-678. Epub 2019 Aug 28.

Division of Human Genetics, National Health Laboratory Service; and School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Familial disease is implicated in 20 - 50% of cases of idiopathic dilated cardiomyopathy (IDCM) worldwide. The contribution of familial factors to IDCM in the Johannesburg area, South Africa, is unknown.

Objectives: To describe the demographic details of patients with IDCM who presented at Charlotte Maxeke Johannesburg Academic Hospital (CMJAH), and to determine if there is evidence of familial disease through family history assessment and clinical screening of relatives. Read More

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http://dx.doi.org/10.7196/SAMJ.2019.v109i9.13936DOI Listing
August 2019
1 Read

First-in-Human Experience With Patient-Specific Computer Simulation of TAVR in Bicuspid Aortic Valve Morphology.

JACC Cardiovasc Interv 2020 01 16;13(2):184-192. Epub 2019 Oct 16.

Cardiology Clinical Academic Group, St. George's, University of London and St. George's University Hospitals NHS Foundation Trust, London, United Kingdom.

Objectives: The aim of this study was to prospectively evaluate the clinical use of patient-specific computer simulation of transcatheter aortic valve replacement (TAVR) in bicuspid aortic valve (BAV) morphology.

Background: Patient-specific computer simulation of TAVR in BAV may predict important clinical outcomes, such as paravalvular regurgitation and conduction disturbance.

Methods: Between May 2018 and April 2019, all patients who were referred for TAVR who had BAV identified on work-up cardiac multidetector computed tomographic imaging prospectively underwent patient-specific computer simulation with a self-expanding transcatheter heart valve (THV) using TAVIguide technology. Read More

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http://dx.doi.org/10.1016/j.jcin.2019.07.032DOI Listing
January 2020
5 Reads

Prevalence of first-degree atrioventricular block and the associated risk factors: a cross-sectional study in rural Northeast China.

BMC Cardiovasc Disord 2019 10 7;19(1):214. Epub 2019 Oct 7.

Department of Cardiovascular Medicine, The First Hospital of China Medical University, Shenyang, 110001, Liaoning, China.

Background: First-degree atrioventricular block (AVB) has traditionally been regarded as a benign condition but recent studies have challenged this conception. Prevalence of 1-2% have been reported in developed countries in Asia. However, no epidemiologic studies have established the prevalence of first-degree AVB in developing countries. Read More

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http://dx.doi.org/10.1186/s12872-019-1202-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781332PMC
October 2019
2 Reads

Safety and efficacy of ozanimod versus interferon beta-1a in relapsing multiple sclerosis (RADIANCE): a multicentre, randomised, 24-month, phase 3 trial.

Lancet Neurol 2019 11 3;18(11):1021-1033. Epub 2019 Sep 3.

Neurologic Clinic and Policlinic, University Hospital and University of Basel, Basel, Switzerland.

Background: Ozanimod is a sphingosine 1-phosphate receptor modulator, which selectively binds to sphingosine 1-phosphate receptor subtypes 1 and 5 with high affinity. In the RADIANCE phase 2 study in participants with relapsing multiple sclerosis, ozanimod was associated with better efficacy than placebo on MRI measures and was well tolerated. The RADIANCE phase 3 study aimed to confirm the safety and efficacy of ozanimod versus interferon beta-1a in individuals with relapsing multiple sclerosis. Read More

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http://dx.doi.org/10.1016/S1474-4422(19)30238-8DOI Listing
November 2019
6 Reads

Safety and efficacy of ozanimod versus interferon beta-1a in relapsing multiple sclerosis (SUNBEAM): a multicentre, randomised, minimum 12-month, phase 3 trial.

Lancet Neurol 2019 11 3;18(11):1009-1020. Epub 2019 Sep 3.

Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, Cleveland, OH, USA.

Background: Ozanimod, a sphingosine 1-phosphate receptor modulator, selectively binds to receptor subtypes 1 and 5 with high affinity. The RADIANCE phase 2 study showed that ozanimod had better efficacy than placebo on MRI measures, with a favourable safety profile, in participants with relapsing multiple sclerosis. The SUNBEAM study aimed to assess the safety and efficacy of ozanimod versus intramuscular interferon beta-1a in participants with relapsing multiple sclerosis. Read More

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http://dx.doi.org/10.1016/S1474-4422(19)30239-XDOI Listing
November 2019
5 Reads

[Inferior myocardial infarction: first Moroccan study of 103 cases].

Pan Afr Med J 2019 31;33:74. Epub 2019 May 31.

Service de Cardiologie B, Université Mohamed V Souissi, Rabat, Maroc.

Myocardial infarction (MI) is a major cause of cardiovascular mortality. Inferior MI accounts for 30-50% of infarctions but it is associated with a favorable prognosis compared to anterior infarct. This study aimed to study the epidemiological, clinical, electrical, echocardiographic, angiographic features of inferior MI, as well as its complications and its therapeutic approaches. Read More

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http://dx.doi.org/10.11604/pamj.2019.33.74.16047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689828PMC
September 2019
2 Reads

Severe Hypoglycemia-Induced Fatal Cardiac Arrhythmias Are Mediated by the Parasympathetic Nervous System in Rats.

Diabetes 2019 11 22;68(11):2107-2119. Epub 2019 Aug 22.

Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, University of Utah, Salt Lake City, UT

The contribution of the sympathetic nervous system (SNS) versus the parasympathetic nervous system (PSNS) in mediating fatal cardiac arrhythmias during insulin-induced severe hypoglycemia is not well understood. Therefore, experimental protocols were performed in nondiabetic Sprague-Dawley rats to test the SNS with ) adrenal demedullation and ) chemical sympathectomy, and to test the PSNS with ) surgical vagotomy, ) nicotinic receptor (mecamylamine) and muscarinic receptor (AQ-RA 741) blockade, and ) ex vivo heart perfusions with normal or low glucose, acetylcholine (ACh), and/or mecamylamine. In protocols 1-4, 3-h hyperinsulinemic (0. Read More

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http://dx.doi.org/10.2337/db19-0306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118248PMC
November 2019
3 Reads

One-Year Follow-Up of Conduction Abnormalities After Transcatheter Aortic Valve Implantation With the SAPIEN 3 Valve.

Am J Cardiol 2019 10 30;124(8):1239-1245. Epub 2019 Jul 30.

Department of Cardiology. Electronic address:

Long-term evolution of new-onset conduction abnormalities and need of permanent pacemaker implantation (PPI) after transcatheter aortic valve implantation (TAVI) have not been extensively evaluated. We describe the incidence and time course of new conduction abnormalities and the rate of PPI with the new-generation transcatheter aortic valve prosthesis Edwards SAPIEN 3 (S3). In total, 266 patients with severe aortic stenosis who underwent TAVI were retrospectively analyzed. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.07.035DOI Listing
October 2019
2 Reads

Transient high-degree right bundle branch block masking the type 1 Brugada ECG pattern associated with possible transient early repolarization syndrome.

Ann Noninvasive Electrocardiol 2020 01 25;25(1):e12673. Epub 2019 Jul 25.

Heart Center, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

The Brugada syndrome (BrS) was the last electrocardiographic syndrome described in the 20th century. The initial description included right bundle branch block (RBBB), persistent ST-segment elevation in the right precordial leads, absence of structural heart disease, and propensity to unexplained syncope and/or sudden death mainly during nocturnal rest. Currently, we know that the first three components are not constant or true since RBBB is present in only 28% of cases, the ST-segment elevation is dynamic, at times absent, and there are discrete structural changes in the right ventricular outflow tract. Read More

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http://dx.doi.org/10.1111/anec.12673DOI Listing
January 2020
3 Reads

Arrhythmias and Adaptations of the Cardiac Conduction System in Former National Football League Players.

J Am Heart Assoc 2019 08 24;8(15):e010401. Epub 2019 Jul 24.

Department of Cardiovascular Medicine, Heart and Vascular Institute Cleveland Clinic Foundation Cleveland OH.

Background Habitual high-intensity endurance exercise is associated with increased atrial fibrillation (AF) risk and impaired cardiac conduction. It is unknown whether these observations extend to prior strength-type sports exposure. The primary aim of this study was to compare AF prevalence in former National Football League (NFL) athletes to population-based controls. Read More

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http://dx.doi.org/10.1161/JAHA.118.010401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761649PMC
August 2019
7 Reads
2.882 Impact Factor

Mechanisms of torsade de pointes tachycardia in patients with spontaneous high-degree atrioventricular block: A modern look at old data.

J Electrocardiol 2019 Sep - Oct;56:55-63. Epub 2019 May 18.

Institut de Cardiologie, Unité de Rythmologie, Hôpital Universitaire La Pitié-Salpêtrière, 47-83 boulevard de l'Hôpital, 75651 Paris, France. Electronic address:

Introduction: The mechanisms of torsade de pointes tachycardia (TdP) are incompletely understood. We aimed to investigate the mechanisms underlying TdP tachycardia in patients with spontaneous high-degree atrioventricular block (AVB).

Methods And Results: This retrospective study reviewed old TdP recordings after ventricular temporary pacing interruption in 16 patients with spontaneous high-degree AVB. Read More

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http://dx.doi.org/10.1016/j.jelectrocard.2019.05.007DOI Listing
May 2019
5 Reads

HYPERTENSIVE HEART DISEASE AND ENCEPHALOPATHY IN A CENTRAL BEARDED DRAGON () WITH SEVERE ATHEROSCLEROSIS AND FIRST-DEGREE ATRIOVENTRICULAR BLOCK.

J Zoo Wildl Med 2019 Jun 13;50(2):482-486. Epub 2019 Jun 13.

Alfort Cardiology Unit (UCA), Centre Hospitalier Universitaire Vétérinaire d'Alfort (CHUVA), National Veterinary School of Alfort, 94704 Maisons-Alfort cedex, France.

A 0.5 kg, 5-yr-old male bearded dragon () presented with a 2-mo history of lethargy, anorexia, and impaired locomotion. Upon physical examination, bradyarrhythmia (heart rate: 20 beats/min) and balance disorders were noted. Read More

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http://dx.doi.org/10.1638/2018-0178DOI Listing
June 2019
6 Reads

Familial Clustering of Cardiac Conduction Defects and Pacemaker Insertion.

Circ Arrhythm Electrophysiol 2019 07 20;12(7):e007150. Epub 2019 Jun 20.

National Heart, Lung, and Blood Institute's Framingham Heart Study, MA (B.M.K., C.A., M.S.D., M.G.L., R.S.V.).

Background: The etiopathogenesis of electrocardiographic bundle branch and atrioventricular blocks is not fully understood. We investigated familial clustering of cardiac conduction defects and pacemaker insertion in the FHS (Framingham Heart Study). Additionally, we assessed familial clustering of pacemaker insertion in the Danish general population. Read More

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http://dx.doi.org/10.1161/CIRCEP.119.007150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588168PMC
July 2019
12 Reads

Beyond first-degree heart block in the diagnosis of acute rheumatic fever.

Cardiol Young 2019 Jun 14;29(6):744-748. Epub 2019 Jun 14.

KidzFirst Children's Hospital,South Auckland,New Zealand.

Objectives: First-degree heart block is a minor manifestation of acute rheumatic fever. Second and third degree heart block and junctional rhythms occur less commonly. We report patients presenting with these latter three electrocardiographic abnormalities and investigate their diagnostic utility. Read More

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http://dx.doi.org/10.1017/S104795111900026XDOI Listing
June 2019
9 Reads

Should fast pathway ablation be reconsidered in typical atrioventricular nodal re-entrant tachycardia?

J Cardiovasc Electrophysiol 2019 09 2;30(9):1569-1577. Epub 2019 Jul 2.

Section of Cardiac Electrophysiology and Pacing, Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.

Introduction: Atrioventricular nodal re-entry tachycardia (AVNRT) is the most common, regular narrow-complex tachycardia. The established treatment is catheter ablation of the AV nodal slow pathway (SP). However, in a select group of patients with long PR intervals in sinus rhythm, SP ablation can lead to AV block due to the absence of robust anterograde conduction through the fast pathway (FP). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jce.14012
Publisher Site
http://dx.doi.org/10.1111/jce.14012DOI Listing
September 2019
8 Reads

A rare association: first degree AV block and long QT syndrome.

Cardiol Young 2019 May 6;29(5):697-698. Epub 2019 Jun 6.

Pediatric Cardiology, Saglik Bilimleri University Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Research and Training Hospital,Istanbul,Turkey.

The coexistence of long QT syndrome with 2:1 or complete atrioventricular blocks has been reported in the literature, but, to the best of our knowledge, this is the first pediatric case of long QT syndrome coexisting with first-degree atrioventricular blocks( 1 - 3 ). Read More

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http://dx.doi.org/10.1017/S1047951119000775DOI Listing
May 2019
5 Reads

Development and Validation of a New Risk Prediction Score for Life-Threatening Ventricular Tachyarrhythmias in Laminopathies.

Authors:
Karim Wahbi Rabah Ben Yaou Estelle Gandjbakhch Frédéric Anselme Thomas Gossios Neal K Lakdawala Caroline Stalens Frédéric Sacher Dominique Babuty Jean-Noel Trochu Ghassan Moubarak Kostantinos Savvatis Raphaël Porcher Pascal Laforêt Abdallah Fayssoil Eloi Marijon Tanya Stojkovic Anthony Béhin Sarah Leonard-Louis Guilhem Sole Fabien Labombarda Pascale Richard Corinne Metay Susana Quijano-Roy Ivana Dabaj Didier Klug Marie-Christine Vantyghem Philippe Chevalier Pierre Ambrosi Emmanuelle Salort Nicolas Sadoul Xavier Waintraub Khadija Chikhaoui Philippe Mabo Nicolas Combes Philippe Maury Jean-Marc Sellal Usha B Tedrow Jonathan M Kalman Jitendra Vohra Alexander F A Androulakis Katja Zeppenfeld Tina Thompson Christine Barnerias Henri-Marc Bécane Eric Bieth Franck Boccara Damien Bonnet Françoise Bouhour Stéphane Boulé Anne-Claire Brehin Françoise Chapon Pascal Cintas Jean-Marie Cuisset Jean-Marc Davy Annachiara De Sandre-Giovannoli Florence Demurger Isabelle Desguerre Klaus Dieterich Julien Durigneux Andoni Echaniz-Laguna Romain Eschalier Ana Ferreiro Xavier Ferrer Christine Francannet Mélanie Fradin Bénédicte Gaborit Arnaud Gay Albert Hagège Arnaud Isapof Isabelle Jeru Raul Juntas Morales Emmanuelle Lagrue Nicolas Lamblin Olivier Lascols Vincent Laugel Arnaud Lazarus France Leturcq Nicolas Levy Armelle Magot Véronique Manel Raphaël Martins Michèle Mayer Sandra Mercier Christophe Meune Maud Michaud Marie-Christine Minot-Myhié Antoine Muchir Aleksandra Nadaj-Pakleza Yann Péréon Philippe Petiot Florence Petit Julien Praline Anne Rollin Pascal Sabouraud Catherine Sarret Stéphane Schaeffer Frederic Taithe Céline Tard Vincent Tiffreau Annick Toutain Camille Vatier Ulrike Walther-Louvier Bruno Eymard Philippe Charron Corinne Vigouroux Gisèle Bonne Saurabh Kumar Perry Elliott Denis Duboc

Circulation 2019 07 3;140(4):293-302. Epub 2019 Jun 3.

APHP, Cochin Hospital, Cardiology Department, FILNEMUS, Centre de Référence de Pathologie Neuromusculaire Nord/Est/Ile de France, Paris-Descartes, Sorbonne Paris Cité University (K.W., D.D.).

Background: An accurate estimation of the risk of life-threatening (LT) ventricular tachyarrhythmia (VTA) in patients with LMNA mutations is crucial to select candidates for implantable cardioverter-defibrillator implantation.

Methods: We included 839 adult patients with LMNA mutations, including 660 from a French nationwide registry in the development sample, and 179 from other countries, referred to 5 tertiary centers for cardiomyopathies, in the validation sample. LTVTA was defined as (1) sudden cardiac death or (2) implantable cardioverter defibrillator-treated or hemodynamically unstable VTA. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.039410DOI Listing
July 2019
39 Reads
14.430 Impact Factor