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    Early-onset Lyme carditis with concurrent disseminated erythema migrans.
    Am J Cardiovasc Dis 2017 15;7(2):53-56. Epub 2017 Apr 15.
    West Virginia University Heart and Vascular InstituteMorgantown, WV, USA.
    Background: Lyme disease is an infection that is estimated to affect over 300,000 people in the United States annually. Typically, it presents with erythema migrans (EM), an annular rash at the site of tick attachment, within 3 to 30 days of inoculation. Untreated patients may progress to early disseminated disease. Read More

    Comparison of effectiveness of right ventricular mid-septal pacing vs. apical pacing: a randomized-controlled trials.
    Eur Heart J Suppl 2016 May 24;18(Suppl F):F12-F18. Epub 2016 May 24.
    Department of Cardiology, First Hospital of Lanzhou University, Lanzhou, Gansu 730000, China.
    The aim of the present study was to compare conventional right ventricular apical pacing (RVAP) with right ventricular mid-septal pacing (RVMSP) in terms of echocardiographic and clinical/biologic features. Ninety-six patients with high-degree atrioventricular block were randomly allocated to RVMSP (n = 50) and RVAP (n = 46). Threshold and impedance, echocardiographic left ventricular ejection fraction, ventricular dyssynchrony features, and distance during a 6-min walk test and Minnesota Living with Heart Failure Questionnaire were determined at 6 and 12 months after pacemaker implantation. Read More

    Discovery of a new mutation in the desmin gene in a young patient with cardiomyopathy and muscular weakness.
    Rom J Morphol Embryol 2017 ;58(1):225-230
    Department of Cardiology, "Prof. Dr. C. C. Iliescu" Institute of Emergency for Cardiovascular Diseases, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;
    A 25-year-old woman with a five years history of syncope, mild left ventricular hypertrophy and moderately enlarged atria, was diagnosed with third degree atrioventricular heart block alternating with atrioventricular heart block 2:1, and received a dual chamber pacemaker. After three years of evolution, she developed atrial fibrillation, marked biatrial enlargement, severely depressed longitudinal myocardial velocities, associated with mild girdle weakness and slight increase in creatine kinase level. The diagnosis of restrictive cardiomyopathy with mild skeletal myopathy imposed the screening for a common etiology. Read More

    Amiodarone-Induced Third Degree Atrioventricular Block and Extreme QT Prolongation Generating Torsade Des Pointes in Paroxysmal Atrial Fibrillation.
    J Atr Fibrillation 2016 Oct-Nov;9(3):1502. Epub 2016 Oct 31.
    Department of Health Sciences's Investigation. Sanatorio Metropolitano. Fernando de la Mora. Paraguay. Cardiology Department, Clinic Hospital, Asunción National University, San Lorenzo, Paraguay.
    Amiodarone is still the most potent antiarrhythmic drug in the prevention of life threatening ventricular arrhythmias and demonstrates a very low incidence of torsade de pointes. An unusual case of an 81-year-old woman who developed serious abnormalities of the conduction system of the heart and torsade des pointes during intravenous infusion of amiodarone for the treatment of paroxysmal atrial fibrillation is described. To the best of our knowledge, this is the first case showing an association of intravenous amiodarone-induced third degree atrioventricular block and extreme QT interval prolongation generating torsade des pointes in a patient with paroxysmal atrial fibrillation who required an implantable cardioverter-defibrillator. Read More

    Atrioventricular block: an unusual complication of Graves' disease.
    BMJ Case Rep 2017 May 3;2017. Epub 2017 May 3.
    Evelina London Children's Hospital, London, UK.
    We report the case of a 10-year-old girl treated with atenolol and carbimazole for tachycardia and hypertension associated with Graves' disease who developed symptomatic 2:1 heart block. 2:1 heart block resolved following cessation of atenolol, reduction in carbimazole dose and treatment of suspected tonsillitis. First-degree atrioventricular block persisted, but gradually normalised following improvement in thyroid status. Read More

    Heart failure in patients with arrhythmogenic right ventricular cardiomyopathy: What are the risk factors?
    Int J Cardiol 2017 Apr 21. Epub 2017 Apr 21.
    Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
    Background: We previously demonstrated that heart failure (HF) was one of the major causes of death in arrhythmogenic right ventricular cardiomyopathy (ARVC). The purpose of this study was to elucidate the clinical impact and risk factors of HF in patients with ARVC.

    Methods And Results: We evaluated cardiac adverse outcomes including HF in 113 consecutive patients with ARVC (85 men, mean age: 44±15years). Read More

    Clinical characteristics associated with bradycardia and asystole in patients with syncope undergoing long-term electrocardiographic monitoring with implantable loop recorder.
    Wien Klin Wochenschr 2017 Apr 27. Epub 2017 Apr 27.
    Cardiology Clinic, Safarik University, VUSCH, Ondavská 8, 04001, Kosice, Slovakia.
    Background: The aim of this retrospective single center cohort study was to assess the occurrence of bradycardia during implantable loop recorder (ILR) monitoring in patients with unexplained syncope and negative conventional testing and to identify clinical predictors of bradycardia and pacemaker implantation.

    Methods: An ILR was implanted in 112 patients (31 men, 81 women, mean age 64 ±13 years) with syncope which was not explained after conventional diagnostic work-up. Clinical variables were compared between patients with and without pacemaker implantation. Read More

    Association of Non-alcoholic Fatty Liver Disease with Conduction Defects on Electrocardiogram.
    Cureus 2017 Mar 21;9(3):e1107. Epub 2017 Mar 21.
    GME Internal Medicine, Orange Park Medical Center.
    Background: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of liver disease in developed countries. The association of NAFLD with conduction defects is unknown. The aim of our study was to find whether an association exists between conduction defects and NAFLD. Read More

    Ivabradine Versus Metoprolol In Patients With Acute Inferior Wall Myocardial Infarction- 'Expanding Arena For Ivabradine'.
    Cardiovasc Ther 2017 Apr 19. Epub 2017 Apr 19.
    Department of cardiology, JLN hospital, Ajmer, Rajasthan, India, 305001.
    Background: Atrioventricular (AV) blocks are of concern with the use of beta blockers in inferior wall myocardial infarction (MI). Ivabradine lowers heart rate with a lesser risk of AV blocks.

    Objectives: To compare ivabradine with metoprolol in acute inferior wall MI in terms of feasibility, tolerability and efficacy METHODS: It was a prospective double blind single centre randomized controlled study. Read More

    Adenosine for postoperative analgesia: A systematic review and meta-analysis.
    PLoS One 2017 23;12(3):e0173518. Epub 2017 Mar 23.
    Department of Anesthesiology, Chinese PLA General Hospital, Beijing, China.
    Purpose: Perioperative infusion of adenosine has been suggested to reduce the requirement for inhalation anesthetics, without causing serious adverse effects in humans. We conducted a meta-analysis of randomized controlled trials evaluating the effect of adenosine on postoperative analgesia.

    Methods: We retrieved articles in computerized searches of Scopus, Web of Science, PubMed, EMBASE, and Cochrane Library databases, up to July 2016. Read More

    Ticagrelor Associated Heart Block: The Need for Close and Continued Monitoring.
    Case Rep Cardiol 2017 26;2017:5074891. Epub 2017 Jan 26.
    Drexel University College of Medicine, Philadelphia, PA, USA; Easton Hospital, PA, USA.
    Ticagrelor is an antiplatelet agent prescribed to prevent the development of adverse cardiac events after acute coronary syndrome (ACS). According to the PLATO trial, ticagrelor is associated with ventricular pauses in the first week of treatment; however, these episodes were felt to be asymptomatic and nonfatal to the patient. We present a case of ticagrelor related second-degree type II heart block causing severe dizziness and diaphoresis that resolved after discontinuation of the medication. Read More

    Cervical plexus anesthesia versus general anesthesia for anterior cervical discectomy and fusion surgery: A randomized clinical trial.
    Medicine (Baltimore) 2017 Feb;96(7):e6119
    aDepartment of Spine Surgery bFinancial Statistics Office, The Third Hospital of HeBei Medical University cThe Orthopaedic Department From First Hospital of Shijiazhuang, Shijiazhuang, China.
    Both general anesthesia (GA) and cervical plexus anesthesia (CPA) can be used for anterior cervical discectomy and fusion (ACDF) surgery. The aim of this study was to evaluate the influence of anesthetic techniques on perioperative mortality and morbidity in patients undergoing cervical surgery.From January 2008 to December 2015, 356 patients who underwent 1-level ACDF for cervical spinal myelopathy were prospectively reviewed. Read More

    Electrocardiographic assessments and cardiac events after fingolimod first dose - a comprehensive monitoring study.
    BMC Neurol 2017 Jan 18;17(1):11. Epub 2017 Jan 18.
    Charité Universitaetsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, Berlin, 13353, Germany.
    Background: First dose observation for cardiac effects is required for fingolimod, but recommendations on the extent vary. This study aims to assess cardiac safety of fingolimod first dose. Individual bradyarrhythmic episodes were evaluated to assess the relevance of continuous electrocardiogram (ECG) monitoring. Read More

    Prevalence and characterization of coronary artery disease in patients with symptomatic bradyarrhythmias requiring pacemaker implantation.
    Indian Heart J 2016 Dec 29;68 Suppl 3:S21-S25. Epub 2016 Jun 29.
    Department of Cardiology, SKIMS, Srinagar, India. Electronic address:
    Background: This study was conducted to assess the prevalence and characterization of CAD in high risk patients requiring pacemaker implantation for symptomatic bradyarrhythmias.

    Methods: This study included 100 patients with symptomatic sinus node dysfunction or atrioventricular block, who were at high risk of CAD or had previously documented atherosclerotic vascular disease (ASCVD). Coronary angiography was performed before pacemaker implantation. Read More

    Early safety and efficacy of fingolimod treatment in Denmark.
    Acta Neurol Scand 2017 Jan 8;135(1):129-133. Epub 2016 Mar 8.
    Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
    Background: Initiation of fingolimod treatment is associated with a transient decrease of heart rate, and atrioventricular (AV) conduction block may occur.

    Objective: To evaluate the therapeutic effect and safety of fingolimod treatment in MS patients in Denmark with focus on cardiac and pulmonary side effects at treatment onset.

    Materials & Methods: We analysed data from the first 496 fingolimod-treated Danish patients, observed for at least 3 months. Read More

    Assessment Of Sinoatrial Node Function In Patients With Persistent And Long-Standing Persistent Forms Of Atrial Fibrillation After Maze III Procedure Combined With Mitral Valve operation.
    J Atr Fibrillation 2016 Jun-Jul;9(1):1408. Epub 2016 Jun 30.
    A.N. Bakoulev Scientific Center for Cardiovascular Surgery.
    Research Objective: Assessment of sinoatrial node function after Maze III procedure combined with a mitral valve operation.

    Methods: 100 patients were included in the research with persistent and long-standing persistent forms of atrial fibrillation (AF) and need of operative treatment concerning valve disease. The following preoperative preparation methods were executed to all patients: Electrocardiogram in 12 standard assignments;Two-dimensional echocardiographic with assessment of systolic and diastolic functions of the left ventricle, size of the left atrium and grade of valve disease;Transesophageal echocardiography for exclusion of blood clots in the left atrium and left atrial appendage;Coronary angiography for exclusion of coronary heart disease;Computer tomography for examination of cardiac chambers and anatomic characteristics of pulmonary veins. Read More

    Lyme Carditis: An Interesting Trip to Third-Degree Heart Block and Back.
    Case Rep Cardiol 2016 6;2016:5454160. Epub 2016 Nov 6.
    Department of Medicine, Memorial Hospital of Rhode Island, Alpert Medical School, Brown University, Pawtucket, RI, USA.
    Carditis is an uncommon presentation of the early disseminated phase of Lyme disease. We present the case of a young female who presented with erythema migrans and was found to have first-degree heart block which progressed to complete heart block within hours. After receiving ceftriaxone, there was complete resolution of the heart block in sequential fashion. Read More

    Steroid pulse therapy was effective for cardiac sarcoidosis with ventricular tachycardia and systolic dysfunction.
    ESC Heart Fail 2016 Dec 4;3(4):288-292. Epub 2016 Jul 4.
    Division of Cardiology and Cardiac Catheterization Laboratories Showa University Northern Yokohama Hospital Yokohama Japan.
    A 32-year-old man presented with palpitation. He was diagnosed with pulmonary sarcoidosis by lung biopsy. The electrocardiogram showed first-degree atrioventricular block and complete right bundle branch block (CRBBB). Read More

    Long-term effects of frequent maximal breath-holding on the cardiac health of elite freedivers.
    Scand J Med Sci Sports 2016 Nov 22;26(11):1283-1286. Epub 2015 Dec 22.
    Department of Cardiology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
    Cardiac arrhythmias are commonly reported in freedivers during maximal voluntary breath-holds, but their influence on the cardiological status and their long-term effects on the cardiac health of these athletes have not been investigated. Here we present the results of a study on 32 healthy young men (mean age 32.6 ± 1. Read More

    Sustained clinical benefit of cardiac resynchronization therapy in non-LBBB patients with prolonged PR-interval: MADIT-CRT long-term follow-up.
    Clin Res Cardiol 2016 Nov 18;105(11):944-952. Epub 2016 Jun 18.
    Heart Research Follow-Up Program, University of Rochester Medical Center, Rochester, NY, USA.
    Objective: In MADIT-CRT, patients with non-LBBB (right bundle branch block or nonspecific ventricular conduction delay) and a prolonged PR-interval derived significant clinical benefit from cardiac resynchronization therapy with defibrillator (CRT-D) compared to an implantable cardioverter defibrillator (ICD)-only. We aimed to study the long-term outcome of non-LBBB patients by baseline PR-interval with CRT-D versus ICD-only.

    Methods: Non-LBBB patients (n = 534) were dichotomized based on baseline PR-interval: normal PR (PR < 230 ms), and markedly prolonged PR (PR ≥ 230 ms). Read More

    Cardiovascular magnetic resonance features of mechanical dyssynchrony in patients with left bundle branch block.
    Int J Cardiovasc Imaging 2016 Sep 15;32(9):1427-1438. Epub 2016 Jun 15.
    Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, 660 First Avenue, Room 411, New York, NY, USA.
    Patients with left bundle branch block (LBBB) can exhibit mechanical dyssynchrony which may contribute to heart failure; such patients may benefit from cardiac resynchronization treatment (CRT). While cardiac magnetic resonance imaging (CMR) has become a common part of heart failure work-up, CMR features of mechanical dyssynchrony in patients with LBBB have not been well characterized. This study aims to investigate the potential of CMR to characterize mechanical features of LBBB. Read More

    Brugada syndrome in the young: an assessment of risk factors predicting future events.
    Europace 2016 Oct 13. Epub 2016 Oct 13.
    Heart Rhythm Management Centre, UZ Brussel-VUB, Brussels, Belgium.
    Aims: To investigate the clinical characteristics, prognoses, and presence of risk factors in young patients with Brugada syndrome (BS).

    Methods And Results: A consecutive cohort of 128 young BS patients (≤25 years old at diagnosis) was analysed. Eighty-eight patients (69%) were asymptomatic, whereas 40 (31%) presented with clinical manifestations of BS. Read More

    Conduction Disorders After Sutureless Aortic Valve Replacement.
    Ann Thorac Surg 2017 Apr 4;103(4):1254-1260. Epub 2016 Oct 4.
    Division of Cardiac Surgery, Montreal Heart Institute, Montreal, Quebec, Canada. Electronic address:
    Background: Sutureless self-expandable aortic bioprostheses rely on radial forces for stabilization, raising concern that these devices may increase the risk of postoperative conduction disease. The purpose of this study was to determine the incidence of conduction disorders after sutureless aortic valve replacement (AVR) with the Perceval S (Sorin Group, Saluggia, Italy) bioprosthesis.

    Methods: Between June 2011 and March 2013, 108 consecutive patients underwent sutureless AVR with the Perceval S prosthesis. Read More

    [Cardiac permanent pacemaker after transcatheter aortic valve implantation: A predictive and scientific review].
    Ann Cardiol Angeiol (Paris) 2016 Nov 29;65(5):346-351. Epub 2016 Sep 29.
    Unité de rythmologie et de stimulation cardiaque, hôpital d'Antony, 1, rue Velpeau, 92160 Antony, France. Electronic address:
    Transcatheter aortic valve implantation (TAVI) is nowadays a worldwide technique in the field of treating aortic stenosis. One of the main side effects linked to the technique are mostly attached to rhythm disturbances, such as atrioventricular (AV) and intraventricular blocks. Consequently, a pacemaker implantation is often required. Read More

    Cardiac Safety Profile of First Dose of Fingolimod for Relapsing-Remitting Multiple Sclerosis in Real-World Settings: Data from a German Prospective Multi-Center Observational Study.
    Neurol Ther 2016 Dec 13;5(2):193-201. Epub 2016 Sep 13.
    Novartis Pharma GmbH, Nuremberg, Germany.
    Introduction: Fingolimod was the first oral therapy approved for the treatment of relapsing-remitting multiple sclerosis (RRMS). Due to its action on cardiac sphingosine 1-phosphate receptors, fingolimod is leading to a transient decrease in heart rate (HR) and the occurrence of rare and asymptomatic self-limited atrioventricular (AV) blocks. This German non-interventional clinical study aimed to assess the cardiac safety profile in RRMS patients during at least 6 h after the initial treatment or restart after interruption of fingolimod in real-world settings. Read More

    Complete Atrioventricular Block Complicating Mitral Infective Endocarditis Caused by Streptococcus Agalactiae.
    Am J Case Rep 2016 Sep 8;17:650-4. Epub 2016 Sep 8.
    Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
    BACKGROUND Infective endocarditis (IE) involving the mitral valve can but rarely lead to complete atrioventricular block (CAVB). CASE REPORT A 74-year-old man with a history of infective endocarditis caused by Streptococcus gordonii (S. gordonii) presented to our emergency room with fever and loss of appetite, which had lasted for 5 days. Read More

    Incidence and predictors of new-onset atrioventricular block requiring pacemaker implantation after sutureless aortic valve replacement.
    Interact Cardiovasc Thorac Surg 2016 Dec 29;23(6):861-868. Epub 2016 Aug 29.
    Department of Cardiology, Heart Institute-Hospital Germans Trias i Pujol, Badalona, Spain.
    Objectives: In high-risk patients with severe aortic stenosis, aortic valve replacement (AVR) with a sutureless Perceval prosthesis (SU-AVR) can be performed instead of conventional AVR or transcatheter aortic valve implantation. Little data are available regarding postoperative conduction disorders after SU-AVR. We aimed to determine the incidence and predictors of new-onset complete atrioventricular block (NO-AVB) requiring permanent cardiac stimulation following SU-AVR. Read More

    Complete heart block in pregnancy: case report, analysis, and review of anesthetic management.
    J Clin Anesth 2016 Sep 27;33:58-61. Epub 2016 Apr 27.
    Department of Anesthesiology, University of Miami Miller School of Medicine, C-300, 1611 NW 12 Ave, Miami, FL 33136 USA.
    Maternal complete heart block can pose significant challenges for the anesthesiologist in the antepartum, peripartum, and postpartum periods. Some patients may present for the first time in the puerperium with dizziness, weakness, syncope, or congestive heart failure as a result of the additional hemodynamic burden that accompanies pregnancy. Although there is an increase in permanent pacemaker placement in young symptomatic patients before pregnancy, prophylactic placement of pacemakers in asymptomatic parturients is not always indicated. Read More

    Identification of discrete epitopes of Ro52p200 and association with fetal cardiac conduction system manifestations in a rodent model.
    Clin Exp Immunol 2016 Dec 13;186(3):284-291. Epub 2016 Sep 13.
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
    Congenital heart block (CHB) is a potentially lethal condition characterized by a third-degree atrioventricular block (AVB). Despite anti-Ro52 antibodies being detected in nearly 90% of mothers of affected children, CHB occurs in only 1-2% of anti-Ro/Sjögren's-syndrome-related antigen A (SSA) autoantibody-positive pregnancies. Maternal antibodies have been suggested to bind molecules crucial to fetal cardiac function; however, it remains unknown whether a single antibody profile associates with CHB or whether several specificities and cross-reactive targets exist. Read More

    Atrioventricular block after ASD closure.
    Heart Asia 2016 1;8(2):26-31. Epub 2016 Aug 1.
    Department of Cardiology, Royal Children's Hospital, Heart Research Group, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia; Department of Pediatrics, University of Melbourne, Melbourne, Victoria, Australia.
    Objective: Secundum atrial septal defect (ASD) is a common congenital heart defect. There is limited data on both early and late atrioventricular (AV) block post ASD closure. The aim of this study was to determine the incidence and risk factors of AV block associated with ASD closure. Read More

    Heart failure due to cytomegalovirus myocarditis in immunocompetent young adults: a case report.
    BMC Res Notes 2016 Aug 5;9:391. Epub 2016 Aug 5.
    Section of Human Pathology, Division of Tropical Diseases, Department of Infectious Diseases, Universidade Federal do Pará, 92 Generalíssimo Deodoro avenue, 66055-240, Umarizal, PA, Brazil.
    Background: Cardiac complications constitute a rare clinical manifestation of cytomegalovirus (CMV) infection. This virus is usually asymptomatic in immunocompetent individuals. We report a case of myocarditis and cardiac insufficiency due to primary CMV infection. Read More

    [Anesthetic Management of a Patient who Developed Intraoperative Paroxysmal Supraventricular Tachycardia with Pulseless Electric Activity].
    Masui 2016 Jun;65(6):636-9
    A 75-year-old woman was scheduled to undergo an ileus operation under general combined with epidural anesthesia. Preoperative electrocardiogram (ECG) showed first-degree atrioventricular block. The patient received no preoperative antiarrhythmic medication. Read More

    Effect of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) on Conduction System Disease.
    JAMA Intern Med 2016 Aug;176(8):1085-92
    Section of Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco.
    Importance: Cardiac conduction abnormalities are associated with an increased risk for morbidity and mortality, and understanding factors that accelerate or delay conduction system disease could help to identify preventive and therapeutic strategies. Antifibrotic and anti-inflammatory properties of angiotensin-converting enzyme inhibitors and treatment for hyperlipidemia may reduce the risk for incident conduction system disease.

    Objective: To identify the effect of pharmacologic therapy randomization and clinical risk factors on the incidence of conduction system disease. Read More

    Long-Term Follow-Up of Children with Heart Block Born from Mothers with Systemic Lupus Erythematosus: A Retrospective Study from the Database Pediatric and Congenital Heart Disease in University Hospitals Leuven.
    Pacing Clin Electrophysiol 2016 Sep 2;39(9):935-43. Epub 2016 Aug 2.
    Congenital and Structural Cardiology, University Hospitals Leuven, Leuven, Belgium.
    Background: Children from mothers with systemic lupus erythematosus are frequently born with congenital heart block. This study aimed at evaluating long-term outcome because long-term data are scarce.

    Methods: In the database of pediatric and congenital heart disease (University Hospitals Leuven), 19 children from systemic lupus erythematosus mothers and who were born with or developed atrioventricular block were identified. Read More

    Heart block following stage 1 palliation of hypoplastic left heart syndrome.
    J Thorac Cardiovasc Surg 2016 Jul 11;152(1):189-94. Epub 2016 Apr 11.
    Department of Cardiology, Boston Children's Hospital and Harvard Medical School, Boston, Mass.
    Objectives: Publicly available data from the Pediatric Heart Network's Single Ventricle Reconstruction Trial was analyzed to determine the prevalence, timing, risk factors for, and impact of second- and third-degree heart block (HB) on outcomes in patients who underwent stage 1 palliation (S1P) for hypoplastic left heart syndrome (HLHS).

    Methods: The presence and date of onset of post-S1P HB occurring within the first year of life, potential risk factors for HB, and factors known to predict poor outcomes after S1P were extracted. Multivariable logistic and Cox regression analyses were performed to identify risk factors for HB and to determine the effect of HB on 3-year transplantation-free survival. Read More

    Electrophysiological Mechanisms of Bayés Syndrome: Insights from Clinical and Mouse Studies.
    Front Physiol 2016 31;7:188. Epub 2016 May 31.
    Department of Medicine and Therapeutics, The Chinese University of Hong KongHong Kong, China; Department of Epidemiology and Preventive Medicine, Monash UniversityMelbourne, VIC, Australia.
    Bayés syndrome is an under-recognized clinical condition characterized by inter-atrial block (IAB). This is defined electrocardiographically as P-wave duration > 120 ms and can be categorized into first, second and third degree IAB. It can be caused by inflammatory conditions such as systemic sclerosis and rheumatoid arthritis, abnormal protein deposition in cardiac amyloidosis, or neoplastic processes invading the inter-atrial conduction system, such as primary cardiac lymphoma. Read More

    Electrocardiography in pre-participation screening and current guidelines for participation in competitive sports.
    Srp Arh Celok Lek 2016 Jan-Feb;144(1-2):104-10
    Electrocardiography (ECG) is especially significant in pre-participation screening due to its ability to discover or to rise a suspicion for certain cardiovascular diseases and conditions that represent a serious health risk in athletes. Common, conditionally benign and training related ECG changes are sinus bradycardia and sinus arrhythmia, first degree atrioventricular block, incomplete right bundle branch block, benign early repolarization, and isolated QRS voltage criteria for left ventricular enlargement. Uncommon ECG changes, unrelated to training, and some specific syndromes are ST segment depression and/or ≥ 2 mm T wave inversion in two or more adjacent leads, intraventricular conduction disorder, Wolf-Parkinson-White syndrome, long QT interval syndrome, short QT interval syndrome, catecholaminergic polymorphic ventricular tachycardia, monomorphic ventricular extrasystole and benign ventricular tachycardia. Read More

    Mobitz type I and II atrioventricular blocks during fingolimod therapy.
    Neurol Sci 2016 Sep 25;37(9):1557-9. Epub 2016 May 25.
    Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, Via Pansini, 5, 80131, Naples, Italy.
    We investigated patients who showed a second-degree atrioventricular block (S-AVB) after the first fingolimod administration. We observed six patients with S-AVB, three Mobitz type I, and three type II. Monitoring continued on the second day for all patients. Read More

    A case of advanced second-degree atrioventricular block in a ferret secondary to lymphoma.
    Open Vet J 2016 15;6(1):68-70. Epub 2016 Apr 15.
    SAFU, Regina Elena Cancer Institute, Via delle Messi d' Oro 156, 00158 Rome, Italy.
    A female ferret was referred as an emergency for severe respiratory distress symptoms. At presentation, the patient was listlessness, dyspnoeic, and hyper-responsive. The clinical examination evidenced dyspnea with cyanosis, altered cardiac rhythm, and hepatomegaly. Read More

    Novel mutations in LMNA A/C gene and associated phenotypes.
    Acta Myol 2015 Dec;34(2-3):116-9
    Cardiomyology and Medical Genetics, Department of Experimental Medicine;
    Mutations in the lamin A/C gene (LMNA) have been associated with several phenotypes ranging from systemic to prevalent of muscle, heart, skin, nerve etc. More recently they have been associated with dilated cardiomyopathy (DCM) and severe forms of arrhythmogenic right ventricular cardiomyopathy (ARVC). We report four novel mutations - 3 missense and 1 deletion - in 4 unrelated patients showing different phenotypes, ranging from the early onset congenital form of laminopathy to classical LGMD phenotype, to LGMD and heart involvement. Read More

    Differential effect of ganglionic plexi ablation in a patient with neurally mediated syncope and intermittent atrioventricular block.
    Europace 2017 Jan 18;19(1):119-126. Epub 2016 May 18.
    Department of Cardiology, Institute for Clinical and Experimental Medicine (IKEM), Vídeňská 1958/9, Prague 140 21, Czech Republic.
    Aims: In patients with severe neurally mediated syncope (NMS), radiofrequency catheter ablation (RFA) of ganglionic plexi (GP) has been proposed as a new therapeutic approach. Cardio-inhibitory response during NMS is usually related to the sinoatrial (SA) and less frequently to atrioventricular (AV) node. Differential effect of GP ablation on SA and AV node is poorly understood. Read More

    Temporary Transvenous Pacemaker Implantation during Carotid Endarterectomy in Patients with Trifascicular Block.
    Ann Vasc Surg 2016 Jul 10;34:206-11. Epub 2016 May 10.
    Cardiothoracic and Vascular Department, Vascular Surgery Unit, IRCCS Ospedale San Raffaele, Milano, Italy; Cardiothoracic and Vascular Department, IRCCS Ospedale San Raffaele, Università Vita-Salute San Raffaele, Milano, Italy.
    Background: The risk of severe perioperative bradyarrhythmias in patients with chronic left bundle branch, or bifascicular block, and an additional first-degree atrioventricular block undergoing carotid endarterectomy (CEA) has never been specifically addressed. In this study, we aimed to investigate whether these conduction abnormalities entail an increased risk of hemodynamic compromise during CEA and the role of temporary transvenous pacemaker (TTVPM) implantation as a prophylactic measure in this subgroup of patients.

    Methods: Between June 2006 and June 2013, 37 CEAs were performed in 31 patients (29 men, mean age 76 ± 6 years), in whom a TTVPM was implanted for a trifascicular block. Read More

    Repair of Partial Atrioventricular Septal Defect: Age and Outcomes.
    Ann Thorac Surg 2016 Jul 25;102(1):170-7. Epub 2016 Apr 25.
    Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
    Background: We evaluated the outcomes of patients undergoing surgical repair of partial atrioventricular septal defect (AVSD) and analyzed the effect of age on outcome.

    Methods: In this single-center retrospective study, we included all children who underwent repair of partial AVSD between 1990 and 2014. We divided the patients into 4 age quartiles (first quartile: 0-0. Read More

    [Efficacy of biventricular pacing on preventing heart failure in patients with high degree atrioventricular block (BIVPACE-AVB Trial)].
    Zhonghua Xin Xue Guan Bing Za Zhi 2016 Apr;44(4):331-7
    Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
    Objective: To investigate the long-term effect of biventricular (BIV) and right ventricular apical (RVA) pacing on cardiac function in patients with high-degree atrioventricular block (AVB) and left ventricular ejection fraction(LVEF)over 35%.

    Methods: A total of 118 consecutive patients with high-degree AVB in six hospitals from East China between May 2009 and December 2012 were enrolled in this randomized, double-blind and parallel controlled study. Patients were randomly assigned to BIV and RVA pacing with or without LV lead on after one-week cardiac resynchronization therapy (CRT). Read More

    Prevalence of arrhythmias among children below 15 years of age with congenital heart diseases attending Mulago National Referral Hospital, Uganda.
    BMC Cardiovasc Disord 2016 Apr 13;16:67. Epub 2016 Apr 13.
    Clinical Epidemiology Unit, Makerere University College of Health Sciences, P.O Box 7072, Kampala, Uganda.
    Background: In Uganda, few children with congenital heart diseases (CHD) benefit from early corrective cardiac surgery. These children are at high risk of developing heart failure and electrolyte imbalances; factors which increase their risk of developing arrhythmias. This study aimed to determine the prevalence and factors associated with arrhythmias among children with congenital heart diseases receiving care at Mulago Hospital. Read More

    Advanced heart block in acute rheumatic fever.
    J Saudi Heart Assoc 2016 Apr 6;28(2):113-5. Epub 2015 Nov 6.
    Department of Pediatrics, Salmaniya Medical Complex, Bahrain.
    First degree heart block is considered a minor criterion for the diagnosis of this condition. The cases presented here demonstrate that higher degrees of heart block do occur in rheumatic fever. Children presenting with acquired heart block should be worked-up for rheumatic fever. Read More

    Aortic annulus to left coronary distance as a predictor for persistent left bundle branch block after TAVI.
    Catheter Cardiovasc Interv 2017 Mar 1;89(4):E162-E168. Epub 2016 Apr 1.
    Department of Cardiology, Munich University Clinic, Ludwig-Maximilian University, Munich, Germany.
    Objectives: To identify potential predictors for ventricular conduction delay and to evaluate the impact of interventricular dyssynchrony on mortality after implantation of a balloon-expandable aortic valve (BEV).

    Methods And Results: Clinical, computertomographical (CT), and electrocardiographical (ECG) data from 225 transcatheter aortic valve implantation (TAVI) patients were analyzed. Procedures were performed between May 2010 and September 2013 via transfemoral access using a BEV. Read More

    Periprocedural temporary pacing in primary percutaneous coronary intervention for patients with acute inferior myocardial infarction.
    Clin Interv Aging 2016 10;11:287-92. Epub 2016 Mar 10.
    Department of Internal Medicine, St Vincent's Hospital, The Catholic University of Korea, Suwon, South Korea.
    Objective: High-degree atrioventricular block (AVB), including complete AVB in acute inferior ST-elevation myocardial infarction (STEMI), is not uncommon. However, there is no study evaluating the clinical differences between patients who have undergone temporary pacing (TP) and patients who have not. The present study was designed to investigate whether TP has any prognostic significance in inferior STEMI complicated by complete AVB. Read More

    Reversible Atrial Fibrillation with Bradycardia Associated with Primary Cardiac B-Cell Lymphoma.
    Intern Med 2016 15;55(6):635-8. Epub 2016 Mar 15.
    Cardiovascular Center, Yokosuka Kyosai Hospital, Japan.
    Primary cardiac lymphoma (PCL) only rarely occurs and it is defined as a lymphoma in which the bulk of the tumor is located within the heart and pericardium. A 53-year-old woman was referred due to dyspnea, and an electrocardiogram exhibited atrial fibrillation (AF). Echocardiography revealed no abnormal findings. Read More

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