285,524 results match your criteria Heart Anatomy


Catheter Ablation of Supraventricular Tachycardia in Patients with Dextrocardia and Situs inversus.

J Cardiovasc Electrophysiol 2019 Jan 19. Epub 2019 Jan 19.

Department of Cardiology, Asklepios Klinik St. Georg, Lohmühlenstraße 5, 20099, Hamburg, Germany.

Background: Dextrocardia with situs inversus is a rare cardiac positional anomaly. Catheter ablation procedures performed in this set of patients are not sufficiently reported.

Methods: A total of 10 patients with dextrocardia and situs inversus, who received catheter ablation for supraventricular tachycardia (SVT), were included from a cohort of over 20,000 cases of catheter ablation for SVT in 3 centers from 2005 to 2016. Read More

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http://dx.doi.org/10.1111/jce.13847DOI Listing
January 2019

Sentinel Lymph Node Biopsy in the Treatment of Endometrial Cancer: Why We Fail? Results of a Prospective Multicenter Study on the Factors Associated with Failure of Node Mapping with Indocyanine Green.

Gynecol Obstet Invest 2019 Jan 18:1-7. Epub 2019 Jan 18.

Department of Obstetrics and Gynecology, Gynecologic Oncology and Minimally Invasive Pelvic Surgery, International School of Surgical Anatomy, IRCCS "Sacro Cuore" Hospital, Verona, Italy.

Background: The sentinel lymph node (SLN) mapping for endometrial cancer staging is gaining wide diffusion, but there is no definitive evidence on the factors associated with the failure of mapping.

Objectives: To analyze the factors associated with the possible failure of bilateral SLN mapping with indocyanine green (ICG).

Methods: A prospective observational study without control on 110 patients with endometrial cancer apparently confined to the uterus, underwent laparoscopic surgical staging with SLN mapping with ICG. Read More

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http://dx.doi.org/10.1159/000496699DOI Listing
January 2019

A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats.

Nat Commun 2019 Jan 18;10(1):329. Epub 2019 Jan 18.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, 94305-5174, CA, USA.

We previously demonstrated that beta II protein kinase C (βIIPKC) activity is elevated in failing hearts and contributes to this pathology. Here we report that βIIPKC accumulates on the mitochondrial outer membrane and phosphorylates mitofusin 1 (Mfn1) at serine 86. Mfn1 phosphorylation results in partial loss of its GTPase activity and in a buildup of fragmented and dysfunctional mitochondria in heart failure. Read More

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http://www.nature.com/articles/s41467-018-08276-6
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http://dx.doi.org/10.1038/s41467-018-08276-6DOI Listing
January 2019
1 Read

Desmoglein 2 mutation provokes skeletal muscle actin expression and accumulation at intercalated discs in murine hearts.

J Cell Sci 2019 Jan 18. Epub 2019 Jan 18.

Institute of Molecular and Cellular Anatomy, RWTH Aachen University, 52074 Aachen, Germany

Arrhythmogenic cardiomyopathy (AC) is an incurable progressive disease that is linked to mutations in genes coding for components of desmosomal adhesions that are localized to the intercalated disc region, which electromechanically couples adjacent cardiomyocytes. To date, the underlying molecular dysfunctions are not well characterized. In two murine AC models, we find an upregulation of the skeletal muscle actin gene () known to be a compensatory reaction to compromised heart function. Read More

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http://dx.doi.org/10.1242/jcs.199612DOI Listing
January 2019
1 Read

Pre-synaptic sympathetic calcium channels, cyclic nucleotide-coupled phosphodiesterases and cardiac excitability.

Semin Cell Dev Biol 2019 Jan 15. Epub 2019 Jan 15.

Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, OX1 3PT, UK. Electronic address:

In sympathetic neurons innervating the heart, action potentials activate voltage-gated Ca channels and evoke Ca entry into presynaptic terminals triggering neurotransmitter release. Binding of transmitters to specific receptors stimulates signal transduction pathways that cause changes in cardiac function. The mechanisms contributing to presynaptic Ca dynamics involve regulation of endogenous Ca buffers, in particular the endoplasmic reticulum, mitochondria and cyclic nucleotide targeted pathways. Read More

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http://dx.doi.org/10.1016/j.semcdb.2019.01.010DOI Listing
January 2019

The role of ubiquitin in cardiac ischemia-reperfusion injury.

Am J Physiol Heart Circ Physiol 2019 Jan 18. Epub 2019 Jan 18.

Anatomy, Biochemistry & Physiology, University of Hawai'i, United States.

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http://dx.doi.org/10.1152/ajpheart.00018.2019DOI Listing
January 2019

Diagnostic Accuracy of Noncontrast Self-navigated Free-breathing MR Angiography versus CT Angiography: A Prospective Study in Pediatric Patients with Suspected Anomalous Coronary Arteries.

Acad Radiol 2019 Jan 14. Epub 2019 Jan 14.

Department of Radiology and Radiological Science, Division of Cardiovascular Imaging, Medical University of South Carolina, 25 Courtenay Drive, Charleston, SC 29425; Division of Pediatric Cardiology, Department of Pediatrics, Medical University of South Carolina, Charleston South Carolina. Electronic address:

Rationale And Objectives: To evaluate the diagnostic accuracy of a prototype noncontrast, free-breathing, self-navigated 3D (SN3D) MR angiography (MRA) technique for the assessment of coronary artery anatomy in children with known or suspected coronary anomalies, using CT angiography (CTA) as the reference standard.

Materials And Methods: Twenty-one children (15 male, 12.3 ± 2. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10766332193000
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http://dx.doi.org/10.1016/j.acra.2018.12.010DOI Listing
January 2019
1 Read

The effects of nifedipine and ivabradine on the functionality of the early rat embryonic heart. Are these drugs a risk in early human pregnancy?

Birth Defects Res 2019 Jan 17. Epub 2019 Jan 17.

Discipline of Anatomy and Histology, Sydney School of Medical Science, The University of Sydney, Sydney, New South Wales, Australia.

Background: When the human heart begins its earliest contractions from day 21, it lacks a functional autonomic nerve supply. Instead, contractions are generated by regular calcium transients later augmented by the funny current (I ) produced by sinoatrial-like cells. This study examined effects of blocking these currents in the early rat embryonic heart. Read More

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http://dx.doi.org/10.1002/bdr2.1457DOI Listing
January 2019

Bursting at the Seams: Molecular Mechanisms Mediating Astrocyte Swelling.

Int J Mol Sci 2019 Jan 15;20(2). Epub 2019 Jan 15.

Departments of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Brain swelling is one of the most robust predictors of outcome following brain injury, including ischemic, traumatic, hemorrhagic, metabolic or other injury. Depending on the specific type of insult, brain swelling can arise from the combined space-occupying effects of extravasated blood, extracellular edema fluid, cellular swelling, vascular engorgement and hydrocephalus. Of these, arguably the least well appreciated is cellular swelling. Read More

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http://dx.doi.org/10.3390/ijms20020330DOI Listing
January 2019

A Phase 1b Trial to Assess the Pharmacokinetics of Ezutromid in Pediatric Duchenne Muscular Dystrophy Patients on a Balanced Diet.

Clin Pharmacol Drug Dev 2019 Jan 16. Epub 2019 Jan 16.

Summit Therapeutics, Abingdon, UK.

Ezutromid (SMT C1100) is a small-molecule utrophin modulator that was developed to treat Duchenne muscular dystrophy (DMD). Previous clinical trials of this agent revealed lower exposure in DMD patients compared with healthy volunteers, which may reflect differences in diet. This study evaluated the pharmacokinetics of ezutromid in patients with DMD who followed a balanced diet. Read More

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http://dx.doi.org/10.1002/cpdd.642DOI Listing
January 2019

Fatal delayed hemopericardium and hemothorax following blunt chest trauma.

Forensic Sci Med Pathol 2019 Jan 16. Epub 2019 Jan 16.

Department of Forensic Medicine, University Hospital Ostrava, CZ-708 52, Ostrava, Czech Republic.

Cardiac injury following blunt chest trauma is common in motor vehicle accidents due to a crush or blast injury. Severe cardiac trauma is associated with a very high mortality. If a cardiac injury develops several weeks after non-penetrating chest trauma, establishing a causal link between the traumatic event and the cardiac injury becomes complicated. Read More

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http://dx.doi.org/10.1007/s12024-018-0069-5DOI Listing
January 2019

Exploration of time sequential, patient specific 3D heart unlocks clinical understanding.

3D Print Med 2018 Dec 6;4(1):15. Epub 2018 Dec 6.

University of Illinois College of Medicine, 1 Illini Drive, Peoria, IL, 61605, USA.

Objectives: The purpose was to create a time sequential three-dimensional virtual reality model, also referred to as a four-dimensional model, to explore its possible benefit and clinical applications. We hypothesized that this novel solution allows for the visuospatial benefits of the 3D model and the dynamic benefits of other existing imaging modalities.

Background: We have seen how 3D models hold great value in medical decision making by eliminating the variable visuospatial skills of practitioners. Read More

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https://threedmedprint.springeropen.com/articles/10.1186/s41
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http://dx.doi.org/10.1186/s41205-018-0034-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283805PMC
December 2018
2 Reads

Initial experience with cinematic rendering for the visualization of extracardiac anatomy in complex congenital heart defects.

Interact Cardiovasc Thorac Surg 2019 Jan 16. Epub 2019 Jan 16.

Department of Pediatric Cardiology, University Hospital Erlangen, Erlangen, Germany.

Objectives: Detailed anatomical information is essential for planning of surgical therapy in patients with congenital heart disease. We wanted to determine whether cinematic rendering, the novel 3-dimensional visualization technique, could help paediatric cardiac surgeons achieve better preoperative visualization of the extracardiac anatomy in patients with complex congenital heart defects. Therefore, cinematic rendering was compared to the traditional volume rendering technique by means of a questionnaire with predefined criteria. Read More

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http://dx.doi.org/10.1093/icvts/ivy348DOI Listing
January 2019

Association of Chronic Low-grade Inflammation With Risk of Alzheimer Disease in ApoE4 Carriers.

JAMA Netw Open 2018 Oct 5;1(6):e183597. Epub 2018 Oct 5.

Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts.

Importance: The association between peripheral inflammatory biomarkers and Alzheimer disease (AD) is not consistent in the literature. It is possible that chronic inflammation, rather than 1 episode of inflammation, interacts with genetic vulnerability to increase the risk for AD.

Objective: To study the interaction between the apolipoprotein E (ApoE) genotype and chronic low-grade inflammation and its association with the incidence of AD. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.3597DOI Listing
October 2018

Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Alzheimers Dement 2019 Jan;15(1):158-167

Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alzheimer's Disease Research Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA. Electronic address:

Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and heterogeneous disease with multiple contributors to its pathophysiology, including vascular dysfunction. The recently updated AD Research Framework put forth by the National Institute on Aging-Alzheimer's Association describes a biomarker-based pathologic definition of AD focused on amyloid, tau, and neuronal injury. In response to this article, here we first discussed evidence that vascular dysfunction is an important early event in AD pathophysiology. Read More

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http://dx.doi.org/10.1016/j.jalz.2018.07.222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338083PMC
January 2019
4 Reads
12.407 Impact Factor

The morphofunctional features of platelets against the background of metabolic syndrome in patients with generalized marginal periodontitis.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):730-733. Epub 2018 Dec 3.

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Department of Operative Surgery and Topographic Anatomy, Moscow, Russia.

According to modern ideas, disorders in the system of hemostasis in cardiovascular diseases are mainly due to an increase in the functional activity of platelets, namely their increased ability to adhere and aggregate. Aim of the research was to evaluate morphofunctional platelets of patients with marginal periodontitis. Material and methods of the study involved 129 men aged 28-50 years (mean age 42. Read More

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http://dx.doi.org/10.1016/j.dsx.2018.11.057DOI Listing
December 2018
1 Read

An optimal strategy for prediction of sudden cardiac death through a pioneering feature-selection approach from HRV signal.

Comput Methods Programs Biomed 2019 Feb 7;169:19-36. Epub 2018 Dec 7.

Biomedical Engineering Department, School of Electrical Engineering, Payame Noor University of North Tehran, Tehran, Iran.

Background And Objective: Taking into consideration the critical importance of Sudden cardiac death (SCD), as it could be the first and the last heart condition to be diagnosed in a person while continuing to claim millions of lives around the world, prediction of sudden cardiac death has increasingly been regarded as a matter of substantive significance. This study does not seek to once again define features to predict and detect SCD, as there already has been adequate discussion addressing feature extraction in our previous works and other recent studies. What seems to be lacking attention is the need for an appropriate strategy to manage the extracted features to such an extent that the best classification is presented. Read More

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http://dx.doi.org/10.1016/j.cmpb.2018.12.001DOI Listing
February 2019

The role of dietary non-heme iron load and peripheral nerve inflammation in the development of peripheral neuropathy (PN) in obese non-diabetic leptin-deficient ob/ob mice.

Neurol Res 2019 Jan 13:1-13. Epub 2019 Jan 13.

b Institute of Anatomy , University of Leipzig , Leipzig , Germany.

Introduction: Here, we investigated inflammatory signs of peripheral nerves in leptin-deficient obese ob/ob mice and the modulating effects of the exogenous iron load.

Methods: Ob/ob and ob/+ control mice were fed with high, standard, or low iron diet for four months.

Results: We found intraepidermal nerve fiber degeneration in foot skin and low-grade neuropathic abnormalities including mildly slowed motor and compound sensory nerve conduction velocities and low-grade macrophage and T-cell infiltration without overt neuropathology in sciatic nerves of all ob/ob mice. Read More

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https://www.tandfonline.com/doi/full/10.1080/01616412.2018.1
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http://dx.doi.org/10.1080/01616412.2018.1564191DOI Listing
January 2019
2 Reads

Ganglion cardiacum or juxtaductal body of human fetuses.

Anat Cell Biol 2018 Dec 29;51(4):266-273. Epub 2018 Dec 29.

Department of Anatomy and Institute of Medical Science, Chonbuk National University Medical School, Jeonju, Korea.

The ganglion cardiacum or juxtaductal body is situated along the left recurrent laryngeal nerve in the aortic window and is an extremely large component of the cardiac nerve plexus. This study was performed to describe the morphologies of the ganglion cardiacum or juxtaductal body in human fetuses and to compare characteristics with intracardiac ganglion. Ganglia were immunostained in specimens from five fetuses of gestational age 12-16 weeks and seven fetuses of gestational age 28-34 weeks. Read More

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http://dx.doi.org/10.5115/acb.2018.51.4.266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318452PMC
December 2018

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

Authors:
Clotilde Théry Kenneth W Witwer Elena Aikawa Maria Jose Alcaraz Johnathon D Anderson Ramaroson Andriantsitohaina Anna Antoniou Tanina Arab Fabienne Archer Georgia K Atkin-Smith D Craig Ayre Jean-Marie Bach Daniel Bachurski Hossein Baharvand Leonora Balaj Shawn Baldacchino Natalie N Bauer Amy A Baxter Mary Bebawy Carla Beckham Apolonija Bedina Zavec Abderrahim Benmoussa Anna C Berardi Paolo Bergese Ewa Bielska Cherie Blenkiron Sylwia Bobis-Wozowicz Eric Boilard Wilfrid Boireau Antonella Bongiovanni Francesc E Borràs Steffi Bosch Chantal M Boulanger Xandra Breakefield Andrew M Breglio Meadhbh Á Brennan David R Brigstock Alain Brisson Marike Ld Broekman Jacqueline F Bromberg Paulina Bryl-Górecka Shilpa Buch Amy H Buck Dylan Burger Sara Busatto Dominik Buschmann Benedetta Bussolati Edit I Buzás James Bryan Byrd Giovanni Camussi David Rf Carter Sarah Caruso Lawrence W Chamley Yu-Ting Chang Chihchen Chen Shuai Chen Lesley Cheng Andrew R Chin Aled Clayton Stefano P Clerici Alex Cocks Emanuele Cocucci Robert J Coffey Anabela Cordeiro-da-Silva Yvonne Couch Frank Aw Coumans Beth Coyle Rossella Crescitelli Miria Ferreira Criado Crislyn D'Souza-Schorey Saumya Das Amrita Datta Chaudhuri Paola de Candia Eliezer F De Santana Olivier De Wever Hernando A Del Portillo Tanguy Demaret Sarah Deville Andrew Devitt Bert Dhondt Dolores Di Vizio Lothar C Dieterich Vincenza Dolo Ana Paula Dominguez Rubio Massimo Dominici Mauricio R Dourado Tom Ap Driedonks Filipe V Duarte Heather M Duncan Ramon M Eichenberger Karin Ekström Samir El Andaloussi Celine Elie-Caille Uta Erdbrügger Juan M Falcón-Pérez Farah Fatima Jason E Fish Miguel Flores-Bellver András Försönits Annie Frelet-Barrand Fabia Fricke Gregor Fuhrmann Susanne Gabrielsson Ana Gámez-Valero Chris Gardiner Kathrin Gärtner Raphael Gaudin Yong Song Gho Bernd Giebel Caroline Gilbert Mario Gimona Ilaria Giusti Deborah Ci Goberdhan André Görgens Sharon M Gorski David W Greening Julia Christina Gross Alice Gualerzi Gopal N Gupta Dakota Gustafson Aase Handberg Reka A Haraszti Paul Harrison Hargita Hegyesi An Hendrix Andrew F Hill Fred H Hochberg Karl F Hoffmann Beth Holder Harry Holthofer Baharak Hosseinkhani Guoku Hu Yiyao Huang Veronica Huber Stuart Hunt Ahmed Gamal-Eldin Ibrahim Tsuneya Ikezu Jameel M Inal Mustafa Isin Alena Ivanova Hannah K Jackson Soren Jacobsen Steven M Jay Muthuvel Jayachandran Guido Jenster Lanzhou Jiang Suzanne M Johnson Jennifer C Jones Ambrose Jong Tijana Jovanovic-Talisman Stephanie Jung Raghu Kalluri Shin-Ichi Kano Sukhbir Kaur Yumi Kawamura Evan T Keller Delaram Khamari Elena Khomyakova Anastasia Khvorova Peter Kierulf Kwang Pyo Kim Thomas Kislinger Mikael Klingeborn David J Klinke Miroslaw Kornek Maja M Kosanović Árpád Ferenc Kovács Eva-Maria Krämer-Albers Susanne Krasemann Mirja Krause Igor V Kurochkin Gina D Kusuma Sören Kuypers Saara Laitinen Scott M Langevin Lucia R Languino Joanne Lannigan Cecilia Lässer Louise C Laurent Gregory Lavieu Elisa Lázaro-Ibáñez Soazig Le Lay Myung-Shin Lee Yi Xin Fiona Lee Debora S Lemos Metka Lenassi Aleksandra Leszczynska Isaac Ts Li Ke Liao Sten F Libregts Erzsebet Ligeti Rebecca Lim Sai Kiang Lim Aija Linē Karen Linnemannstöns Alicia Llorente Catherine A Lombard Magdalena J Lorenowicz Ákos M Lörincz Jan Lötvall Jason Lovett Michelle C Lowry Xavier Loyer Quan Lu Barbara Lukomska Taral R Lunavat Sybren Ln Maas Harmeet Malhi Antonio Marcilla Jacopo Mariani Javier Mariscal Elena S Martens-Uzunova Lorena Martin-Jaular M Carmen Martinez Vilma Regina Martins Mathilde Mathieu Suresh Mathivanan Marco Maugeri Lynda K McGinnis Mark J McVey David G Meckes Katie L Meehan Inge Mertens Valentina R Minciacchi Andreas Möller Malene Møller Jørgensen Aizea Morales-Kastresana Jess Morhayim François Mullier Maurizio Muraca Luca Musante Veronika Mussack Dillon C Muth Kathryn H Myburgh Tanbir Najrana Muhammad Nawaz Irina Nazarenko Peter Nejsum Christian Neri Tommaso Neri Rienk Nieuwland Leonardo Nimrichter John P Nolan Esther Nm Nolte-'t Hoen Nicole Noren Hooten Lorraine O'Driscoll Tina O'Grady Ana O'Loghlen Takahiro Ochiya Martin Olivier Alberto Ortiz Luis A Ortiz Xabier Osteikoetxea Ole Østergaard Matias Ostrowski Jaesung Park D Michiel Pegtel Hector Peinado Francesca Perut Michael W Pfaffl Donald G Phinney Bartijn Ch Pieters Ryan C Pink David S Pisetsky Elke Pogge von Strandmann Iva Polakovicova Ivan Kh Poon Bonita H Powell Ilaria Prada Lynn Pulliam Peter Quesenberry Annalisa Radeghieri Robert L Raffai Stefania Raimondo Janusz Rak Marcel I Ramirez Graça Raposo Morsi S Rayyan Neta Regev-Rudzki Franz L Ricklefs Paul D Robbins David D Roberts Silvia C Rodrigues Eva Rohde Sophie Rome Kasper Ma Rouschop Aurelia Rughetti Ashley E Russell Paula Saá Susmita Sahoo Edison Salas-Huenuleo Catherine Sánchez Julie A Saugstad Meike J Saul Raymond M Schiffelers Raphael Schneider Tine Hiorth Schøyen Aaron Scott Eriomina Shahaj Shivani Sharma Olga Shatnyeva Faezeh Shekari Ganesh Vilas Shelke Ashok K Shetty Kiyotaka Shiba Pia R-M Siljander Andreia M Silva Agata Skowronek Orman L Snyder Rodrigo Pedro Soares Barbara W Sódar Carolina Soekmadji Javier Sotillo Philip D Stahl Willem Stoorvogel Shannon L Stott Erwin F Strasser Simon Swift Hidetoshi Tahara Muneesh Tewari Kate Timms Swasti Tiwari Rochelle Tixeira Mercedes Tkach Wei Seong Toh Richard Tomasini Ana Claudia Torrecilhas Juan Pablo Tosar Vasilis Toxavidis Lorena Urbanelli Pieter Vader Bas Wm van Balkom Susanne G van der Grein Jan Van Deun Martijn Jc van Herwijnen Kendall Van Keuren-Jensen Guillaume van Niel Martin E van Royen Andre J van Wijnen M Helena Vasconcelos Ivan J Vechetti Tiago D Veit Laura J Vella Émilie Velot Frederik J Verweij Beate Vestad Jose L Viñas Tamás Visnovitz Krisztina V Vukman Jessica Wahlgren Dionysios C Watson Marca Hm Wauben Alissa Weaver Jason P Webber Viktoria Weber Ann M Wehman Daniel J Weiss Joshua A Welsh Sebastian Wendt Asa M Wheelock Zoltán Wiener Leonie Witte Joy Wolfram Angeliki Xagorari Patricia Xander Jing Xu Xiaomei Yan María Yáñez-Mó Hang Yin Yuana Yuana Valentina Zappulli Jana Zarubova Vytautas Žėkas Jian-Ye Zhang Zezhou Zhao Lei Zheng Alexander R Zheutlin Antje M Zickler Pascale Zimmermann Angela M Zivkovic Davide Zocco Ewa K Zuba-Surma

J Extracell Vesicles 2018 23;7(1):1535750. Epub 2018 Nov 23.

Jagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Department of Cell Biology, Kraków, Poland.

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. Read More

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https://www.tandfonline.com/doi/full/10.1080/20013078.2018.1
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http://dx.doi.org/10.1080/20013078.2018.1535750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322352PMC
November 2018
11 Reads

Feeding methods for infants with single ventricle physiology are associated with length of stay during stage 2 surgery hospitalization.

Congenit Heart Dis 2019 Jan 12. Epub 2019 Jan 12.

Department of Pediatrics, Otolaryngology, Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: Tube feedings are often needed to achieve the growth and nutrition goals associated with decreased morbidity and mortality in patients with single ventricle anatomy. Variability in feeding method through the interstage period has been previously described, however, comparable information following stage 2 palliation is lacking.

Objectives: To identify types of feeding methods following stage 2 palliation and their influence on length of stay. Read More

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http://doi.wiley.com/10.1111/chd.12742
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http://dx.doi.org/10.1111/chd.12742DOI Listing
January 2019
1 Read

Elevated risk for iron depletion in high-school age blood donors.

Transfusion 2019 Jan 11. Epub 2019 Jan 11.

Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin.

Background: High school students 16 to 18 years-old contribute 10% of the US blood supply. Mitigating iron depletion in these donors is important because they continue to undergo physical and neurocognitive development.

Study Design And Methods: Study objectives were to determine the prevalence of iron depletion in 16- to 18-year-old donors and whether their risk for iron depletion was greater than adult donors. Read More

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http://doi.wiley.com/10.1111/trf.15133
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http://dx.doi.org/10.1111/trf.15133DOI Listing
January 2019
2 Reads

Cardiac Findings in Fetal and Pediatric Autopsies: A 15-Year Retrospective Review.

Fetal Pediatr Pathol 2019 Jan 11:1-16. Epub 2019 Jan 11.

a Pathology, Faculty of Medicine , Chulalongkorn University , Bangkok , Thailand.

Introduction: Congenital heart defects (CHDs) carry significant morbidity and mortality in pediatric patients. This study determined the spectrum of CHDs based on fetal and pediatric autopsies.

Methods: Autopsy reports over a 15-year period were reviewed. Read More

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http://dx.doi.org/10.1080/15513815.2018.1546355DOI Listing
January 2019

Long-term functional and structural preservation of precision-cut human myocardium under continuous electromechanical stimulation in vitro.

Nat Commun 2019 Jan 10;10(1):117. Epub 2019 Jan 10.

Walter-Brendel-Centre of Experimental Medicine, University Hospital, LMU Munich, Marchioninistr. 27, 81377, Munich, Germany.

In vitro models incorporating the complexity and function of adult human tissues are highly desired for translational research. Whilst vital slices of human myocardium approach these demands, their rapid degeneration in tissue culture precludes long-term experimentation. Here, we report preservation of structure and performance of human myocardium under conditions of physiological preload, compliance, and continuous excitation. Read More

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http://dx.doi.org/10.1038/s41467-018-08003-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328583PMC
January 2019

'Heart development and morphogenesis' is a novel pathway for human ovarian granulosa cell differentiation during long‑term in vitro cultivation‑a microarray approach.

Mol Med Rep 2019 Jan 8. Epub 2019 Jan 8.

Department of Anatomy, Poznan University of Medical Sciences, 60‑781 Poznań, Poland.

Granulosa cells (GCs) have many functions in the endocrine system. Most notably, they produce progesterone following ovulation. However, it has recently been proven that GCs can change their properties when subjected to long‑term culture. Read More

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http://dx.doi.org/10.3892/mmr.2019.9837DOI Listing
January 2019
1 Read

[Senile rheumatoid arthritis associated with rheumatoid lung: a caricatural observation].

Pan Afr Med J 2018 6;30:253. Epub 2018 Aug 6.

Service de Médecine Interne B, Hôpital Charles Nicolle, Université de Tunis El Manar, Faculté de Médecine de Tunis, Tunis, Tunisie.

In the elderly, rheumatoid arthritis is defined by an average age of onset over 60 years. Prognosis mainly depends upon functional capacity, evolutionary stage of the disease, onset or no onset of joint malformations. We report the case of a 70-year old female patient with a history of arterial hypertension, hypothyroidism and Sjögren syndrome diagnosed in 2005. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.253.16372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307917PMC
January 2019
2 Reads

Total anomalous pulmonary vein drainage in a 60-year-old woman diagnosed in an ECG-gated multidetector computed tomography - a case report and review of literature.

Pol J Radiol 2018 5;83:e334-e339. Epub 2018 Jul 5.

I Department of Medical Radiology, Medical University of Lublin, Lublin, Poland.

Purpose: Total anomalous pulmonary vein drainage (TAPVD) is a congenital cardiac defect in which there is no connection between pulmonary veins and the left atrium. Pulmonary veins form a confluence independent of the left atrium and drain to a systemic vein. TAPVD types are: supracardiac, cardiac, infracardiac, and mixed. Read More

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https://www.termedia.pl/doi/10.5114/pjr.2018.77696
Publisher Site
http://dx.doi.org/10.5114/pjr.2018.77696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323547PMC
July 2018
2 Reads

Bicuspid Aortic Valve Anatomy and Relationship With Devices: The BAVARD Multicenter Registry.

Circ Cardiovasc Interv 2019 Jan;12(1):e007107

Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands (L.v.G., N.M.V.M.).

Background: Sizing for transcatheter aortic valve implantation in bicuspid aortic valves (BAV) remains controversial.

Methods And Results: The aim of the BAVARD (Bicuspid Aortic Valve Anatomy and Relationship With Devices) retrospective registry is to capture the sizing ratios used for transcatheter aortic valve implantation in BAV and analyze the second-generation prostheses geometry postimplantation. About 101 patients with BAV along with available pre- and post-transcatheter aortic valve implantation multidetector computed tomography were compared with 88 tricuspid aortic valves (TAV) patients. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.11
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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.007107DOI Listing
January 2019
7 Reads

Acute Infection and Myocardial Infarction.

N Engl J Med 2019 01;380(2):171-176

From the Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston (D.M.M.); National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (M.S.A.); and the Ottawa Hospital Research Institute and University of Ottawa, Ottawa (V.F.C.-M.).

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http://www.nejm.org/doi/10.1056/NEJMra1808137
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http://dx.doi.org/10.1056/NEJMra1808137DOI Listing
January 2019
8 Reads

Congenital abnormalities of the aortic arch: revisiting the 1964 Stewart classification.

Cardiovasc Pathol 2018 Dec 6;39:38-50. Epub 2018 Dec 6.

Department of Obstetrics & Gynecology, Howard University, College of Medicine, Washington, DC 20060, USA. Electronic address:

The traditional classification of congenital aortic arch abnormalities was described by James Stewart and colleagues in 1964. Since that time, advances in diagnostic imaging technology have led to better delineation of the vasculature anatomy and the identification of previously unrecognized and unclassified anomalies. In this manuscript, we review the existing literature and propose a series of modifications to the original Stewart classification of congenital aortic arch abnormalities to incorporate this new knowledge. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10548807183018
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http://dx.doi.org/10.1016/j.carpath.2018.11.004DOI Listing
December 2018
3 Reads

Hydrogen Sulfide Attenuates Renin Angiotensin and Aldosterone Pathological Signaling to Preserve Kidney Function and Improve Exercise Tolerance in Heart Failure.

JACC Basic Transl Sci 2018 Dec 31;3(6):796-809. Epub 2018 Dec 31.

Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana.

Cardioprotective effects of HS have been well documented. However, the lack of evidence supporting the benefits afforded by delayed HS therapy warrants further investigation. Using a murine model of transverse aortic constriction-induced heart failure, this study showed that delayed HS therapy protects multiple organs including the heart, kidney, and blood-vessel; reduces oxidative stress; attenuates renal sympathetic and renin-angiotensin-aldosterone system pathological activation; and ultimately improves exercise capacity. Read More

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http://dx.doi.org/10.1016/j.jacbts.2018.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315048PMC
December 2018
1 Read

A Severe Case of Aneurysmal Malformation of the Vein of Galen, Cardiac Failure and Intrauterine Fetal Death.

Curr Health Sci J 2018 Jan-Mar;44(1):76-79. Epub 2018 Mar 29.

Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, Romania.

Aneurism of the vein of Galen is a rare congenital anomaly, where complex arteriovenous malformation are identified between multiple choroidal arteries and the median prosencephalic vein of Markowski, which is a precursor of the vein of Galen, with subsequent aneurysmal enlargement of the respective arteriovenous system. The congenital malformation develops during week 6 to 11 of fetal development. Infants often die from high-output congestive heart failure. Read More

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http://dx.doi.org/10.12865/CHSJ.44.01.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295180PMC

Pharmacological Modulation of Mitochondrial Ca Content Regulates Sarcoplasmic Reticulum Ca Release via Oxidation of the Ryanodine Receptor by Mitochondria-Derived Reactive Oxygen Species.

Front Physiol 2018 21;9:1831. Epub 2018 Dec 21.

Department of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, United States.

In a physiological setting, mitochondria increase oxidative phosphorylation during periods of stress to meet increased metabolic demand. This in part is mediated via enhanced mitochondrial Ca uptake, an important regulator of cellular ATP homeostasis. In a pathophysiological setting pharmacological modulation of mitochondrial Ca uptake or retention has been suggested as a therapeutic strategy to improve metabolic homeostasis or attenuate Ca-dependent arrhythmias in cardiac disease states. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2018.01831
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http://dx.doi.org/10.3389/fphys.2018.01831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308295PMC
December 2018
4 Reads

Nonpathological Chondrogenic Features of Valve Interstitial Cells in Normal Adult Zebrafish.

J Histochem Cytochem 2019 Jan 8:22155418824083. Epub 2019 Jan 8.

Institute of Anatomy, Faculty of Medicine.

In the heart, unidirectional blood flow depends on proper heart valve function. As, in mammals, regulatory mechanisms of early heart valve and bone development are shown to contribute to adult heart valve pathologies, we used the animal model zebrafish (ZF, Danio rerio) to investigate the microarchitecture and differentiation of cardiac valve interstitial cells in the transition from juvenile (35 days) to end of adult breeding (2.5 years) stages. Read More

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http://dx.doi.org/10.1369/0022155418824083DOI Listing
January 2019

Cancer biomarkers in atherosclerotic plaque: Evidenced from structural and proteomic analyses.

Biochem Biophys Res Commun 2019 Feb 5;509(3):687-693. Epub 2019 Jan 5.

Stem Cell and Regenerative Medicine Group, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, 14965/161, Iran. Electronic address:

Atherosclerosis and cancer are the leading causes of mortality around the world that share common pathogenic pathways. The aim of this study is the investigation of the protein profile of atherosclerotic plaque in order to find similar biomarker between cancer and atherosclerosis. The small pieces of human coronary artery containing advanced atherosclerotic plaque is obtained from patients during bypass surgery. Read More

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http://dx.doi.org/10.1016/j.bbrc.2018.12.160DOI Listing
February 2019
1 Read

Reserve of Right Ventricular-Arterial Coupling in the Setting of Chronic Overload.

Circ Heart Fail 2019 Jan;12(1):e005512

Department of Internal Medicine (K.T., A.D., J.A., H.A.G., W.S., N.S., J.W., H.G., M.J.R.).

Background: Right ventricular (RV) maladaptation and failure determine outcome in pulmonary hypertension. The adaptation of RV function to loading (RV-pulmonary arterial coupling) is defined by a ratio of end-systolic to arterial elastances (Ees/Ea). How RV-pulmonary arterial coupling relates to pulmonary hypertension severity and onset of RV failure (defined by excessive volume increase and ejection fraction [EF] decrease) is not exactly known. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.118
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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005512DOI Listing
January 2019
1 Read

Advances in cellular and humoral immunotherapy - implications for the treatment of poor risk childhood, adolescent, and young adult B-cell non-Hodgkin lymphoma.

Br J Haematol 2019 Jan 6. Epub 2019 Jan 6.

Department of Pediatrics, New York Medical College, Valhalla, NY, USA.

Patients with relapsed, refractory or advanced stage B non-Hodgkin lymphoma (NHL) continue to have a dismal prognosis. This review summarises current and novel cellular and immunotherapy for these high-risk populations, including haematopoietic stem cell transplant, bispecific antibodies, viral-derived cytotoxic T cells, chimeric antigen receptor (CAR) T cells, and natural killer (NK) cell therapy, as discussed at the 6th International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma on September 26th-29th 2018 in Rotterdam, the Netherlands, and explores the future of NK/CAR NK therapies. Read More

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http://dx.doi.org/10.1111/bjh.15753DOI Listing
January 2019
1 Read

Full-field analysis of epicardial strain in an in vitro porcine heart platform.

J Mech Behav Biomed Mater 2018 Nov 30;91:294-300. Epub 2018 Nov 30.

Mathematical Modelling in Medicine Group, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK; Insigneo Institute for in Silico Medicine, University of Sheffield, Sheffield, UK. Electronic address:

The quantitative assessment of cardiac strain is increasingly performed to provide valuable insights on heart function. Currently, the most frequently used technique in the clinic is ultrasound-based speckle tracking echocardiography (STE). However, verification and validation of this modality are still under investigation and further reference measurements are required to support this activity. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2018.11.025DOI Listing
November 2018

Effects of the isothiocyanate sulforaphane on TGF-β1-induced rat cardiac fibroblast activation and extracellular matrix interactions.

J Cell Physiol 2019 Jan 4. Epub 2019 Jan 4.

Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina.

An important step in many pathological conditions, particularly tissue and organ fibrosis, is the conversion of relatively quiescent cells into active myofibroblasts. These are highly specialized cells that participate in normal wound healing but also contribute to pathogenesis. These cells possess characteristics of smooth muscle cells and fibroblasts, have enhanced synthetic activity secreting abundant extracellular matrix components, cytokines, and growth factors, and are capable of generating contractile force. Read More

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http://dx.doi.org/10.1002/jcp.28075DOI Listing
January 2019
1 Read

Cardiac sigma receptors - an update.

Physiol Res 2018 Dec;67(Supplementum 4):S561-S576

Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

More than four decades passed since sigma receptors were first mentioned. Since then, existence of at least two receptor subtypes and their tissue distributions have been proposed. Nowadays, it is clear, that sigma receptors are unique ubiquitous proteins with pluripotent function, which can interact with so many different classes of proteins. Read More

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December 2018

African Americans are less likely to have elective endovascular repair of abdominal aortic aneurysms.

J Vasc Surg 2019 Jan 1. Epub 2019 Jan 1.

Division of Vascular Surgery, Penn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pa. Electronic address:

Objective: Recently published Society for Vascular Surgery guidelines recommend endovascular aneurysm repair (EVAR) for both elective and emergent treatment of abdominal aortic aneurysm in patients with suitable anatomy. Racial disparities in health care are well known. The aim of this study was to stratify the patients undergoing EVAR on the basis of their racial differences and to determine the differences in preoperative, intraoperative, and postoperative variables among patients of different races. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.10.107DOI Listing
January 2019
1 Read
3.021 Impact Factor

Single-Stage Complete Repair versus Multistage Repair of Tetralogy of Fallot with Borderline Pulmonary Arteries.

Heart Surg Forum 2018 Nov 13;21(6):E466-E471. Epub 2018 Nov 13.

Department of Cardiothoracic Surgery, Al Ahrar Hospital, Zagazig, Egypt.

Background: Tetralogy of Fallot is the most common cyanotic congenital heart defect. Borderline pulmonary anatomy has been associated with a higher risk of mortality and morbidity. Strategies to manage this condition-namely, single- or multistage repair-have long been debated. Read More

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http://dx.doi.org/10.1532/hsf.2075DOI Listing
November 2018
2 Reads

Surgical Treatment for Hypertrophic Obstructive Cardiomyopathy with Concomitant Mitral Valve Abnormalities: A Cohort of 26 Cases.

Heart Surg Forum 2018 Nov 7;21(6):E443-E447. Epub 2018 Nov 7.

Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

Background: We sought to analyze the pathological characteristics of hypertrophic obstructive cardiomyopathy (HOCM) with concomitant mitral valve abnormalities and to discuss the surgical treatment strategies.

Methods: The clinical data of 26 HOCM patients treated from January 2014 to March 2016 were retrospectively analyzed. There were 19 males and 7 females with a mean age of 47 ± 16 years (range, 10-70 years). Read More

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http://dx.doi.org/10.1532/hsf.2013DOI Listing
November 2018
2 Reads

Magnetic resonance and computed tomography imaging fusion for live guidance of percutaneous pulmonary valve implantation.

Postepy Kardiol Interwencyjnej 2018 11;14(4):413-421. Epub 2018 Dec 11.

Department of Congenital Heart Disease/Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany.

Introduction: Until recently, two-dimensional (2D) angiography was the mainstay of guidance for percutaneous pulmonary valve implantation (PPVI). Recent advances in fusion software have enabled direct fusion of pre-intervention imaging, magnetic resonance imaging (MRI) or computed tomography (CT) scans, to create a reliable three-dimensional (3D) roadmap for procedural guidance.

Aim: To report initial two-center experience with direct 2D-3D image fusion for live guidance of PPVI with MRI- and CT-derived 3D roadmaps. Read More

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http://dx.doi.org/10.5114/aic.2018.79871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309845PMC
December 2018

Correction: Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders.

Mol Psychiatry 2019 Jan 2. Epub 2019 Jan 2.

Institute for Microscopic Anatomy and Neurobiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.

Following the publication of this article the authors noted that Torfi Sigurdsson's name was misspelled. Instead of Sigrudsson it should be Sigurdsson. The PDF and HTML versions of the paper have been modified accordingly. Read More

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http://dx.doi.org/10.1038/s41380-018-0320-1DOI Listing
January 2019

Zn-alloy provides a novel platform for mechanically stable bioresorbable vascular stents.

PLoS One 2019 2;14(1):e0209111. Epub 2019 Jan 2.

Optimed GmbH, Ettlingen, Germany.

Metallic Zn alloys have recently gained interest as potential candidates for developing platforms of bioresorbable vascular stents (BVS). Previous studies revealed that Mg alloys used for BVS can degrade too early, whereas PLLA materials may fail to provide effective scaffolding properties. Here we report on results of a new bioresorbable, metallic stent made from a Zn-Ag alloy studied in a porcine animal model of thrombosis and restenosis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209111PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314592PMC
January 2019

Candida Endocarditis after TAVR.

N Engl J Med 2019 Jan;380(1):e1

University Hospital, University of Bern, Bern, Switzerland

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http://dx.doi.org/10.1056/NEJMicm1809948DOI Listing
January 2019
1 Read

A Breath-Taking Diagnosis.

N Engl J Med 2019 01;380(1):81-87

From the Department of Medicine, Brigham and Women's Hospital, Boston.

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http://dx.doi.org/10.1056/NEJMcps1807721DOI Listing
January 2019
1 Read

[The effectiveness of Ilizarov technique-based transverse tibial bone transport on treatment of severe diabetic foots complicated with systemic inflammation response syndrome].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 Oct;32(10):1261-1266

Department of Bone and Joint Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning Guangxi, 530021,

Objective: To evaluate the effectiveness of Ilizarov technique-based transverse tibial bone transport on the treatment of severe diabetic foot ulcer (Wagner grades 3 to 5) complicated with systemic inflammatory response syndrome (SIRS).

Methods: Between August 2014 and December 2017, 33 patients with severe diabetic foot and SIRS were treated with Ilizarov technique-based transverse tibial bone transport. There were 27 males and 6 females, with a mean age of 60. Read More

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http://www.rrsurg.com/article/10.7507/1002-1892.201805024
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http://dx.doi.org/10.7507/1002-1892.201805024DOI Listing
October 2018
3 Reads

Complexities of transcatheter mitral valve replacement (TMVR) and why it is not transcatheter aortic valve replacement (TAVR).

Ann Cardiothorac Surg 2018 Nov;7(6):724-730

Department of Cardiovascular Surgery, Houston Methodist Hospital, Houston, Texas, USA.

Transcatheter mitral valve replacement (TMVR) is currently being investigated as a procedural alternative to surgical mitral valve repair or replacement (SMVR). Early data from first-in-man trials with current devices suggest that TMVR is technically feasible but carries a high mortality. This is substantially different from the early success transcatheter aortic valve replacement (TAVR) has seen and is related to complexities of the mitral valve anatomy, differences in pathology that require mitral valve replacement as well as the impact that mitral valve replacement has on physiology and cardiac function, irrespective of the modality by which the mitral valve is replaced. Read More

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http://dx.doi.org/10.21037/acs.2018.10.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288216PMC
November 2018
1 Read