287,451 results match your criteria Heart Anatomy


Increase of NOX3 in heart failure of hereditary cardiomyopathy.

Can J Physiol Pharmacol 2019 Mar 21. Epub 2019 Mar 21.

University of Sherbrooke, 7321, Anatomy and Cell Biology, Faculty of Medicine, Sherbrooke, Quebec, Canada ;

During the development of heart failure in humans and animal models, an increase in reactive oxygen species (ROS) levels were observed. However, there is no information whether this increase of ROS is associated with an increase in the density of a specific isoform of NADPH oxidases (NOX1-5). The objective of this study was to verify whether the densities of NOXs 1-5 change during the development of heart failure. Read More

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http://dx.doi.org/10.1139/cjpp-2019-0055DOI Listing

Heart ventricular histology and microvasculature together with aortic histology and elastic lamellar structure: A comparison of a novel dual-purpose to a broiler chicken line.

PLoS One 2019 21;14(3):e0214158. Epub 2019 Mar 21.

Institute of Veterinary Anatomy, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.

The use of dual-purpose chickens is a strategy to avoid killing one-day-old male chicks of egg laying lines. Lohmann Dual (LD) is a novel dual-purpose chicken line created by the crossbreeding of layer and broiler lines. However, many of the cardiovascular diseases of broilers are likely to be associated with intensive genetic selection for growth and feed conversion efficiency. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214158PLOS
March 2019
1 Read

Placental epigenetics for evaluation of fetal congenital heart defects: Ventricular Septal Defect (VSD).

PLoS One 2019 21;14(3):e0200229. Epub 2019 Mar 21.

Department of Obstetrics and Gynecology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan, United States of America.

Ventricular Septal Defect (VSD), the most common congenital heart defect, is characterized by a hole in the septum between the right and left ventricles. The pathogenesis of VSD is unknown in most clinical cases. There is a paucity of data relevant to epigenetic changes in VSD. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200229PLOS

Simultaneous 3D whole-heart bright-blood and black blood imaging for cardiovascular anatomy and wall assessment with interleaved T prep-IR.

Magn Reson Med 2019 Mar 21. Epub 2019 Mar 21.

School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.

Purpose: To develop a motion-corrected 3D flow-insensitive imaging approach interleaved T prepared-inversion recovery (iT prep-IR) for simultaneous lumen and wall visualization of the great thoracic vessels and cardiac structures.

Methods: A 3D flow-insensitive approach for simultaneous cardiovascular lumen and wall visualization (iT prep) has been previously proposed. This approach requires subject-dependent weighted subtraction to completely null the arterial blood signal in the black-blood volume. Read More

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http://dx.doi.org/10.1002/mrm.27734DOI Listing

Comparison of supine or prone crawl photon or proton breast and regional lymph node radiation therapy including the internal mammary chain.

Sci Rep 2019 Mar 18;9(1):4755. Epub 2019 Mar 18.

Department of Radiotherapy and Experimental Cancer Research, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

We report on a dosimetrical study comparing supine (S) and prone-crawl (P) position for radiotherapy of whole breast (WB) and loco-regional lymph node regions, including the internal mammary chain (LN_IM). Six left sided breast cancer patients were CT-simulated in S and P positions and four patients only in P position. Treatment plans were made using non-coplanar volumetric modulated arc photon therapy (VMAT) or pencil beam scanning intensity modulated proton therapy (IMPT). Read More

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http://dx.doi.org/10.1038/s41598-019-41283-1DOI Listing

Novel Approach to Elucidate Human Baroreflex Regulation at the Brainstem Level: Pharmacological Testing During fMRI.

Front Neurosci 2019 5;13:193. Epub 2019 Mar 5.

Somatosensory and Autonomic Therapy Research, Institute for Neuroradiology, Hannover Medical School, Hanover, Germany.

Brainstem nuclei govern the arterial baroreflex, which is crucial for heart rate and blood pressure control. Yet, brainstem function is difficult to explore in living humans and is therefore mostly studied using animal models or postmortem human anatomy studies. We developed a methodology to identify brainstem nuclei involved in baroreflex cardiovascular control in humans by combining pharmacological baroreflex testing with functional magnetic resonance imaging. Read More

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http://dx.doi.org/10.3389/fnins.2019.00193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411827PMC

Neuromodulation Approaches for Cardiac Arrhythmias: Recent Advances.

Curr Cardiol Rep 2019 Mar 18;21(5):32. Epub 2019 Mar 18.

UCLA Cardiac Arrhythmia Center, UCLA Neurocardiology Research Center, David Geffen School of Medicine at UCLA, University of California, 100 Medical Plaza, Suite 660, Westwood Blvd, Los Angeles, CA, 90095-1679, USA.

Purpose Of Review: This review aims to describe the latest advances in autonomic neuromodulation approaches to treating cardiac arrhythmias, with a focus on ventricular arrhythmias.

Recent Findings: The increasing understanding of neuronal remodeling in cardiac diseases has led to the development and improvement of novel neuromodulation therapies targeting multiple levels of the autonomic nervous system. Thoracic epidural anesthesia, spinal cord stimulation, stellate ganglion modulatory therapies, vagal stimulation, renal denervation, and interventions on the intracardiac nervous system have all been studied in preclinical models, with encouraging preliminary clinical data. Read More

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http://link.springer.com/10.1007/s11886-019-1120-1
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http://dx.doi.org/10.1007/s11886-019-1120-1DOI Listing
March 2019
5 Reads

Mesenchymal actomyosin contractility is required for androgen-driven urethral masculinization in mice.

Commun Biol 2019 8;2:95. Epub 2019 Mar 8.

1Department of Developmental Genetics, Institute of Advanced Medicine, Wakayama Medical University, Wakayama, 641-8509 Japan.

The morphogenesis of mammalian embryonic external genitalia (eExG) shows dynamic differences between males and females. In genotypic males, eExG are masculinized in response to androgen signaling. Disruption of this process can give rise to multiple male reproductive organ defects. Read More

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http://dx.doi.org/10.1038/s42003-019-0336-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408527PMC

The rationale for isolation of the left atrial pulmonary venous component to control atrial fibrillation: a review article.

Heart Rhythm 2019 Mar 15. Epub 2019 Mar 15.

Cardiology Clinical Academic Group, St. George's University of London, United Kingdom.

Catheter ablation of persistent atrial fibrillation is an evolving field. In this review, we discuss the rationale for the isolation of the pulmonary venous component of the left atrium to control atrial fibrillation. The review describes the embryological origin of this component and makes the important distinction between the true posterior wall and the pulmonary venous component, which forms the dome of the left atrium. Read More

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http://dx.doi.org/10.1016/j.hrthm.2019.03.012DOI Listing

Six-Month Results of Treatment-Blinded Medication Titration for Hypertension Control Following Randomization to Endovascular Ultrasound Renal Denervation or a Sham Procedure in the RADIANCE-HTN SOLO Trial.

Circulation 2019 Mar 17. Epub 2019 Mar 17.

Columbia University Medical Center/New York-Presbyterian Hospital and the Cardiovascular Research Foundation, New York, NY.

Background: The multicenter, international, randomized, blinded, sham-controlled RADIANCE-HTN SOLO trial demonstrated a 6.3 mmHg greater reduction in daytime ambulatory systolic blood pressure (BP) at 2 months by endovascular ultrasound renal denervation (RDN) compared with a sham procedure among patients not treated with antihypertensive medications. We report 6-month results following the addition of a recommended standardized stepped-care antihypertensive treatment (SSAHT) to the randomized endovascular procedure under continued blinding to initial treatment. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.040451DOI Listing

Breast Arterial Calcium: A Game Changer in Women's Cardiovascular Health?

JACC Cardiovasc Imaging 2019 Mar 8. Epub 2019 Mar 8.

Department of Cardiology, Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Medical Institutions, Baltimore, Maryland; Cardiology Department, Bellvitge University Hospital and Bellvitge Biomedical Research Institute, L'Hospitalet de Llobregat, Barcelona, Spain; Research Triangle Institute Health Solutions, Pharmacoepidemiology and Risk Management, Barcelona, Spain. Electronic address:

In 2018, cardiovascular disease (CVD) was the leading cause of death among women, and current CVD prevention paradigms may not be sufficient in this group. In that context, it has recently been proposed that detection of calcification in breast arteries may help improve CVD risk screening and assessment in apparently healthy women. This review provides an overview of breast arterial anatomy; and the epidemiology, pathophysiology, and measurement of breast artery calcium (BAC); and discusses the features of the BAC-CVD link. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.07.035DOI Listing
March 2019
1 Read

Glioblastoma cancer stem cell biology: Potential theranostic targets.

Drug Resist Updat 2019 Mar 8;42:35-45. Epub 2019 Mar 8.

Pediatric Stem Cell Transplant Department, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Glioblastoma multiforme (GBM) is among the most incurable cancers. GBMs survival rate has not markedly improved, despite new radical surgery protocols, the introduction of new anticancer drugs, new treatment protocols, and advances in radiation techniques. The low efficacy of therapy, and short interval between remission and recurrence, could be attributed to the resistance of a small fraction of tumorigenic cells to treatment. Read More

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http://dx.doi.org/10.1016/j.drup.2018.03.003DOI Listing
March 2019
9.121 Impact Factor

Morphology of the vasa vasorum in coronary arteries of the porcine heart: a new insight.

Ann Anat 2019 Mar 12. Epub 2019 Mar 12.

Department of Anatomy, Third Faculty of Medicine, Charles University, Prague, Czech Republic; Centre of Scientific Information, Third Faculty of Medicine, Charles University, Prague, Czech Republic. Electronic address:

Introduction: The vasa vasorum interna were described during the last decade as a special kind of vessels originating directly from the lumen of the paternal artery and participating in the nourishment of its wall, especially of the aorta and coronary arteries. At the same time, their existence was repeatedly denied/negated by many other authors.

Aim: The purpose of the actual study was the anatomical verification of the existence of the vasa vasorum interna in porcine coronary arteries. Read More

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http://dx.doi.org/10.1016/j.aanat.2019.02.006DOI Listing

Influence of experimental alcoholism on the repair process of bone defects filled with beta-tricalcium phosphate.

Drug Alcohol Depend 2019 Feb 16;197:315-325. Epub 2019 Feb 16.

Department of Biological Sciences (Anatomy), Bauru School of Dentistry, University of São Paulo (USP), Bauru, Brazil; Medical School, University of Marilia (UNIMAR), Marília, Brazil. Electronic address:

This study evaluated the effect of ethanol on the repair in calvaria treated with beta-tricalcium phosphate (β-TCP). Forty rats were distributed into 2 groups: Water group (CG, n = 20) and Alcohol Group (AG, n = 20), which received 25% ethanol ad libitum after an adaptation period of 3 weeks. After 90 days of liquid diet, the rats were submitted to a 5. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.12.031DOI Listing
February 2019
1 Read

Dystextia and dystypia as modern stroke symptoms: A case series and literature review.

Clin Neurol Neurosurg 2019 Feb 23;180:25-27. Epub 2019 Feb 23.

Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, N6A 5A5, Canada; Stroke, Dementia & Heart Disease Laboratory. Western University, London, Ontario, N6A 5C1, Canada; Department of Anatomy & Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, N6A 5A5, Canada; Department of Epidemiology & Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, Ontario, N6A 5A5, Canada.

Stroke recognition remains a barrier to care in cerebrovascular disease. Despite an increasing reliance on digital communication, the clinical utility of deficits relating to technology remains unexplored. Dystextia and dystypia, terms used to refer to impairments in texting and typing, respectively, may serve as modern indicators of stroke and provide information regarding stroke duration, symptomatology, and etiological diagnosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467193002
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http://dx.doi.org/10.1016/j.clineuro.2019.02.001DOI Listing
February 2019
1 Read

Assessing Blood Clotting and Coagulation Factors in Mice.

Curr Protoc Mouse Biol 2019 Mar 15:e61. Epub 2019 Mar 15.

Department of Biological Sciences, Oakland University, Rochester, Michigan.

The mammalian blood coagulation system was designed to restrict blood loss due to injury as well as keep the blood fluid within the blood vessels of the organism. Blood coagulation activity in inbred mouse strains varies widely among strains, suggesting that many genomic variants affect hemostasis. Some of these molecules have been discovered and characterized; however, many are still unknown. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cpmo.61
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http://dx.doi.org/10.1002/cpmo.61DOI Listing
March 2019
4 Reads

Reporting sex or gender in anatomical research: which is appropriate?

Clin Anat 2019 Mar 15. Epub 2019 Mar 15.

International Evidence-Based Anatomy Working Group, Krakow, Poland.

Sex- and gender-based differences need to be considered in evidence-based medical research as there are anatomical and physiological differences between males and females. Females are underrepresented in studies, with results from males often generalized to both sexes. The SAGER guidelines were published in 2016 to address sex- and gender-bias in research. Read More

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http://dx.doi.org/10.1002/ca.23375DOI Listing

Ethanol fixation method for heart and lung imaging in micro-CT.

Jpn J Radiol 2019 Mar 14. Epub 2019 Mar 14.

Specialized Laboratory of Experimental Imaging, Third Faculty of Medicine, Charles University, Prague, Czech Republic.

Purpose: The soft tissue imaging in micro-CT remains challenging due to its low intrinsic contrast. The aim of this study was to create a simple staining method omitting the usage of contrast agents for ex vivo soft tissue imaging in micro-CT.

Materials And Methods: Hearts and lungs from 30 mice were used. Read More

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http://dx.doi.org/10.1007/s11604-019-00830-6DOI Listing

Mitochondrial Dynamics in Tachycardiomyopathy.

Cell Physiol Biochem 2019 15;52(3):435-438. Epub 2019 Mar 15.

Department of Cardiology and Cardiovascular Diseases, University of Tübingen, Tübingen, Germany,

Background/aims: Tachycardiomyopathy (TCM) is a largely reversible form of non-ischemic heart failure. The underlying mechanism are, however, still today poorly understood. Recent data indicate distinct changes in mitochondrial distribution in these patients, compared to other non-ischemic cardiomyopathies. Read More

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http://dx.doi.org/10.33594/000000031DOI Listing
March 2019
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Feasibility of mapping and cannulation of the porcine epicardial lymphatic system for sampling and decompression in heart failure research.

J Clin Transl Res 2019 Jan 18;4(2):105-112. Epub 2018 Jul 18.

Department of Pathology, Academic Medical Center, Amsterdam, the Netherlands.

Background And Aim: The cardiac lymphatic system drains excess fluid from the cardiac interstitium. Any impairment or dysfunction of the lymph structures can result in the accumulation of interstitial fluid, and may lead to edema and eventually cardiac dysfunction. Lymph originates directly from the interstitium and carries real-time information about the metabolic state of cells in specific regions of the heart. Read More

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January 2019

The hematopoietic organ of Macrobrachium rosenbergii: Structure, organization and immune status.

Fish Shellfish Immunol 2019 Mar 11;88:415-423. Epub 2019 Mar 11.

Center of Excellence for Shrimp Molecular Biology and Biotechnology (Centex Shrimp), Faculty of Science, Mahidol University, Faculty of Science, Mahidol University, Rama VI Rd., Bangkok, 10400, Thailand; Department of Anatomy, Faculty of Science, Mahidol University, Rama VI Rd., Bangkok, 10400, Thailand. Electronic address:

The hematopoietic organ (HO) of the giant freshwater prawn Macrobrachium rosenbergii is a discrete, whitish mass located in the epigastric region of the cephalothorax, posterior to the brain. It is composed of hematopoietic cells arranged in a thick layer of numerous lobules that surround a central hemal sinus from which they are separated by a thin sheath. At the center of the sinus is the muscular cor frontale. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.03.011DOI Listing

Autonomic regulation of preterm infants is enhanced by Family Nurture Intervention.

Dev Psychobiol 2019 Mar 13. Epub 2019 Mar 13.

Department of Pediatrics, Columbia University Medical Center, New York, New York.

Preterm infants have maturational delays in several neurobehavioral systems. This study assesses the impact of the Family Nurture Intervention (FNI) in the neonatal intensive care unit (NICU) on the maturation of autonomic regulation of preterm infants. Preterm infants born at 26-34 weeks postmenstrual age (PMA) were assigned to groups receiving either standard care (SC) or SC plus FNI, using a randomized controlled trial design. Read More

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http://dx.doi.org/10.1002/dev.21841DOI Listing

Rare Copy Number Variations Might Not be Involved in the Molecular Pathogenesis of PA-IVS in an Unselected Chinese Cohort.

Pediatr Cardiol 2019 Mar 13. Epub 2019 Mar 13.

Department of Pediatric Cardiothoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, 1678 Dongfang Road, Shanghai, 200127, China.

Congenital heart defect (CHD) is one of the most common birth defects in China, while pulmonary atresia with intact ventricular septum (PA-IVS) is the life-threatening form of CHD. Numerous previous studies revealed that rare copy number variants (CNVs) play important roles in CHD, but little is known about the prevalence and role of rare CNVs in PA-IVS. In this study, we conducted a genome-wide scanning of rare CNVs in an unselected cohort consisted of 54 Chinese patients with PA-IVS and 20 patients with pulmonary atresia with ventricular septal defect (PA-VSD). Read More

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http://dx.doi.org/10.1007/s00246-019-02062-xDOI Listing
March 2019
1 Read

Homozygous frameshift mutations in FAT1 cause a syndrome characterized by colobomatous-microphthalmia, ptosis, nephropathy and syndactyly.

Nat Commun 2019 Mar 12;10(1):1180. Epub 2019 Mar 12.

Centre de Recherche en Génomique des Pathologies Humaines (GENOPATH), Faculté de Médecine et de Pharmacie, Mohammed V University of Rabat, 10100, Rabat, Morocco.

A failure in optic fissure fusion during development can lead to blinding malformations of the eye. Here, we report a syndrome characterized by facial dysmorphism, colobomatous microphthalmia, ptosis and syndactyly with or without nephropathy, associated with homozygous frameshift mutations in FAT1. We show that Fat1 knockout mice and zebrafish embryos homozygous for truncating fat1a mutations exhibit completely penetrant coloboma, recapitulating the most consistent developmental defect observed in affected individuals. Read More

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http://dx.doi.org/10.1038/s41467-019-08547-wDOI Listing
March 2019
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Profiles and characteristics of bronchial responsiveness in general 7-year-old children.

Pediatr Pulmonol 2019 Mar 11. Epub 2019 Mar 11.

Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Background: Although bronchial responsiveness (BR) is usually categorized as normal or hyperresponsive to aid the diagnosis of asthma, it exists on a continuous spectrum, not in a dichotomous manner. We aimed to evaluate the distribution profile of BR in a general population of 7-year-olds.

Methods: In 2015, 7-year-old Korean children from a nationwide birth cohort study visited regional study hospitals for skin prick test, standard spirometry, and bronchial provocation to establish reference values for the general population. Read More

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http://dx.doi.org/10.1002/ppul.24310DOI Listing
March 2019
1 Read

Neuropeptide-Y causes coronary microvascular constriction and is associated with reduced ejection fraction following ST-elevation myocardial infarction.

Eur Heart J 2019 Mar 11. Epub 2019 Mar 11.

Department of Cardiovascular Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford, UK.

Aims: The co-transmitter neuropeptide-Y (NPY) is released during high sympathetic drive, including ST-elevation myocardial infarction (STEMI), and can be a potent vasoconstrictor. We hypothesized that myocardial NPY levels correlate with reperfusion and subsequent recovery following primary percutaneous coronary intervention (PPCI), and sought to determine if and how NPY constricts the coronary microvasculature.

Methods And Results: Peripheral venous NPY levels were significantly higher in patients with STEMI (n = 45) compared to acute coronary syndromes/stable angina ( n = 48) or with normal coronary arteries (NC, n = 16). Read More

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http://dx.doi.org/10.1093/eurheartj/ehz115DOI Listing
March 2019
1 Read
15.203 Impact Factor

OCT-guided Percutaneous Coronary Intervention in Bifurcation Lesions.

Interv Cardiol 2019 Feb;14(1):5-9

Interventional Structural Cardiology Division, Department of Heart, Lung and Vessels, Careggi University Hospital Florence, Italy.

Coronary artery bifurcation lesions remain challenging despite significant advancements in stent technology and development of specific bifurcation stenting approaches. Optical coherence tomography (OCT) is the intracoronary imaging technique with the highest resolution and can generate automatically contoured lumen areas across the variable geometry of bifurcation lesions. Knowledge of plaque severity and composition facilitates planning of the best strategy for percutaneous coronary intervention (PCI) and stenting. Read More

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http://dx.doi.org/10.15420/icr.2018.17.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406124PMC
February 2019

Potential Deep Brain Stimulation Targets for the Management of Refractory Hypertension.

Front Neurosci 2019 25;13:93. Epub 2019 Feb 25.

Department of Neurological Surgery, Neurological Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, United States.

Hypertension is the single greatest contributor to human disease and mortality affecting over 75 million people in the United States alone. Hypertension is defined according to the American College of Cardiology as systolic blood pressure (SBP) greater than 120 mm Hg and diastolic blood pressure (DBP) above 80 mm Hg measured on two separate occasions. While there are multiple medication classes available for blood pressure control, fewer than 50% of hypertensive patients maintain appropriate control. Read More

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http://dx.doi.org/10.3389/fnins.2019.00093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397890PMC
February 2019
1 Read

Feasibility of multi-atlas cardiac segmentation from thoracic planning CT in a probabilistic framework.

Phys Med Biol 2019 Mar 11. Epub 2019 Mar 11.

Institute of Medical Physics, University of Sydney School of Physics, Sydney, New South Wales, AUSTRALIA.

Toxicity to cardiac and coronary structures is an important late morbidity for patients undergoing left-sided breast radiotherapy. Many current studies have relied on estimates of cardiac doses assuming standardised anatomy, with a calculated increase in relative risk of 7.4% per Gy (mean heart dose). Read More

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http://dx.doi.org/10.1088/1361-6560/ab0ea6DOI Listing
March 2019
1 Read

Vitamin D3 Supplementation Ameliorates Ovariectomy-Induced Cardiac Apoptotic and Structural Changes in Adult Albino Rats.

Can J Physiol Pharmacol 2019 Mar 11. Epub 2019 Mar 11.

Zagazig University Faculty of Human Medicine, 68865, pharmacology, Zagazig, Egypt ;

The effect of vitamin D on cardiac dysfunction after menopause is still under investigation. Therefore, we investigated the effect of vitamin D3 on cardiac apoptotic and structural changes in ovariectomized rats. Forty adult female albino rats were divided into 4 equal groups: sham rats, sham rats treated with vitamin D3, ovariectomized rats and ovariectomized rats treated with vitamin D3 (500 IU/kg/day/6 weeks, orally). Read More

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http://dx.doi.org/10.1139/cjpp-2018-0674DOI Listing

Evaluating 3D-printed models of coronary anomalies: a survey among clinicians and researchers at a university hospital in the UK.

BMJ Open 2019 Mar 8;9(3):e025227. Epub 2019 Mar 8.

Bristol Medical School, University of Bristol, Bristol, UK.

Objective: To evaluate the feasibility of three-dimensional (3D) printing models of coronary artery anomalies based on cardiac CT data and explore their potential for clinical applications.

Design: Cardiac CT datasets of patients with various coronary artery anomalies (n=8) were retrospectively reviewed and processed, reconstructing detailed 3D models to be printed in-house with a desktop 3D printer (Form 2, Formlabs) using white resin.

Setting: A University Hospital (division of cardiology) in the UK. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025227DOI Listing
March 2019
2.063 Impact Factor

Failure to detect an association between self-reported traumatic brain injury and Alzheimer's disease neuropathology and dementia.

Alzheimers Dement 2019 Mar 6. Epub 2019 Mar 6.

Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA. Electronic address:

Introduction: Recent research with neuropathologic or biomarker evidence of Alzheimer's disease (AD) casts doubt on traumatic brain injury (TBI) as a risk factor for AD. We leveraged the National Alzheimer's Coordinating Center to examine the association between self-reported TBI with loss of consciousness and AD neuropathologic changes, and with baseline and longitudinal clinical status.

Methods: The sample included 4761 autopsy participants (453 with remote TBI with loss of consciousness; 2822 with AD neuropathologic changes) from National Alzheimer's Coordinating Center. Read More

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http://dx.doi.org/10.1016/j.jalz.2018.12.015DOI Listing
March 2019
1 Read
12.407 Impact Factor

Age, sex, and setting in the etiology of stroke study (ASSESS): Study design and protocol.

J Neurol Sci 2019 Feb 14;399:209-213. Epub 2019 Feb 14.

Department of Clinical Neurological Sciences, University Hospital, London Health Sciences Center, Western University, ON, Canada; Department of Epidemiology and Biostatistics, Western University, ON, Canada. Electronic address:

Rationale: Stroke etiology and risk factors vary by age, sex, setting (hospital or community-based) and by region. Identifying these differences would improve our understanding of stroke etiology, diagnosis, and treatment.

Aim: The Age, Sex and Setting in the Etiology of Stroke Study (ASSESS) is a multicenter cohort study to assess differences in stroke etiology. Read More

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http://dx.doi.org/10.1016/j.jns.2019.02.024DOI Listing
February 2019
4 Reads

miRNA analysis with Prost! reveals evolutionary conservation of organ-enriched expression and post-transcriptional modifications in three-spined stickleback and zebrafish.

Sci Rep 2019 Mar 8;9(1):3913. Epub 2019 Mar 8.

Institute of Neuroscience, University of Oregon, Eugene, OR, 97403, USA.

MicroRNAs (miRNAs) can have organ-specific expression and functions; they can originate from dedicated miRNA genes, from non-canonical miRNA genes, or from mirror-miRNA genes and can also experience post-transcriptional variation. It remains unclear, however, which mechanisms of miRNA production or modification are organ-specific and the extent of their evolutionary conservation. To address these issues, we developed the software Prost! (PRocessing Of Short Transcripts), which, among other features, helps quantify mature miRNAs, accounts for post-transcriptional processing, such as nucleotide editing, and identifies mirror-miRNAs. Read More

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http://dx.doi.org/10.1038/s41598-019-40361-8DOI Listing

Endosuture aneurysm repair in patients treated with Endurant II/IIs in conjunction with Heli-FX EndoAnchor implants for short-neck abdominal aortic aneurysm.

J Vasc Surg 2019 Mar 5. Epub 2019 Mar 5.

Department of Surgery, University of Tennessee, Memphis, Tenn.

Objective: Endovascular repair of abdominal aortic aneurysm (AAA) remains a challenging clinical scenario when there is a short or nonexistent segment of healthy infrarenal aorta. This study sought to determine the safety and effectiveness of endosuture aneurysm repair (ESAR) using the Endurant II/IIs endograft (Medtronic Vascular, Santa Rosa, Calif) in conjunction with Heli-FX EndoAnchors (Medtronic Vascular) in the treatment of short-neck AAA.

Methods: In this subgroup analysis, 70 patients were identified from the Aneurysm Treatment Using the Heli-FX EndoAnchor System Global Registry (ANCHOR) who had an infrarenal neck length <10 mm down to 4 mm based on core laboratory measurements. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.11.033DOI Listing
March 2019
2 Reads

Mid-term outcomes of individualized surgeries in patients with Ebstein's anomaly.

Heart Vessels 2019 Mar 8. Epub 2019 Mar 8.

Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China.

The variable anatomy of Ebstein's anomaly leads to its various surgical procedures. The long-term outcomes of different operations were not well established. Thirty-five patients with Ebstein's anomaly who underwent operations from 2006 to 2018 in our department were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s00380-019-01358-5DOI Listing
March 2019
3 Reads

Author Correction: PP2A negatively regulates the hypertrophic response by dephosphorylating HDAC2 S394 in the heart.

Exp Mol Med 2019 Mar 7;51(3):27. Epub 2019 Mar 7.

Department of Pharmacology, Chonnam National University Medical School, Hwasun, 58128, Republic of Korea.

After the publication of this article, the authors noticed an error in one of the grant numbers (2015R1A2A1A05001708) in the Acknowledgements section. Read More

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http://dx.doi.org/10.1038/s12276-019-0222-6DOI Listing
March 2019
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3.446 Impact Factor

Multimodality Imaging of the Tricuspid Valve and Right Heart Anatomy.

JACC Cardiovasc Imaging 2019 Mar;12(3):516-531

Department of Cardiac, Thoracic, and Vascular Sciences, University of Padua, Padua, Italy; IRCCS, Instituto Auxologico Italiano, S. Luca Hospital, University of Milano-Bicocca, Milan, Italy.

The characterization of tricuspid valve and right-heart anatomy has been gaining significant interest in the setting of new percutaneous transcatheter interventions for tricuspid regurgitation. Multimodality cardiac imaging provides a wealth of information about the anatomy and function of the tricuspid valve apparatus, right ventricle, and right atrium, which is pivotal for diagnosis and prognosis and for planning of percutaneous interventions. The present review describes the role of echocardiography, cardiac magnetic resonance, and multidetector row cardiac computed tomography for right heart and tricuspid valve assessment. Read More

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http://dx.doi.org/10.1016/j.jcmg.2019.01.006DOI Listing

Anatomy and Physiology of the Tricuspid Valve.

JACC Cardiovasc Imaging 2019 Mar;12(3):458-468

NewYork-Presbyterian/Columbia University Irving Medical Center, New York, New York; Cardiovascular Research Foundation, New York, New York. Electronic address:

An appreciation of the complex and variable anatomy of the tricuspid valve is essential to unraveling the pathophysiology of tricuspid regurgitation. A greater appreciation of normal and abnormal anatomy is important as new methods of treating the tricuspid regurgitation are developed. This review of tricuspid valve and right heart anatomy is followed by a discussion of the possible pathophysiology of secondary (functional) tricuspid regurgitation. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.07.032DOI Listing

Sexual dimorphism in the control of skeletal muscle interstitial PO of heart failure rats: Effects of dietary nitrate supplementation.

J Appl Physiol (1985) 2019 Mar 7. Epub 2019 Mar 7.

Kinesiology, Anatomy and Physiology, Kansas State University, United States.

Sex differences in the mechanisms underlying cardiovascular pathophysiology of O transport in heart failure (HF) remain to be explored. In HF, nitric oxide (NO) bioavailability is reduced and contributes to deficits in O delivery-to-utilization matching. Females may rely more on NO for cardiovascular control and as such experience greater decrements in HF. Read More

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http://dx.doi.org/10.1152/japplphysiol.01004.2018DOI Listing

Melatonin protects against streptozotocin-induced diabetic cardiomyopathy through the mammalian target of rapamycin (mTOR) signaling pathway.

Adv Clin Exp Med 2019 Mar 7. Epub 2019 Mar 7.

Department of Cardiology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.

Background: Several studies demonstrated that the overexpression of mammalian target of rapamycin (mTOR) signaling protein is associated with cardiomyopathy. However, the effect of mTOR on the heart in hyperglycemic condition is still controversial.

Objectives: We aimed to investigate the expression of mTOR and antioxidant enzyme activity in cardiac hypertrophy in rats with streptozotocin-induced diabetes mellitus (DM), and the effects of the melatonin on diabetic cardiomyopathy (DCM). Read More

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http://dx.doi.org/10.17219/acem/103799DOI Listing

The Bilateral Bidirectional Glenn Operation as a Risk Factor Prior to Fontan Completion in Complex Congenital Heart Disease Patients.

World J Pediatr Congenit Heart Surg 2019 Mar;10(2):174-181

1 The Edmond J. Safra International Congenital Heart Center, Sheba Medical Center, Ramat Gan, Israel.

Introduction:: The Glenn procedure is generally performed as a second-stage palliative procedure toward the completion of Fontan circulation in patients with a functionally univentricular heart. Safe Fontan completion requires normal ventricular function, competent atrioventricular valves, normal pulmonary arteries anatomy, and low pulmonary vascular resistances (PVRs), which is merely an estimation that considers both lungs as a single unit. Clinical observations revealed that patients who previously underwent bilateral bidirectional cavopulmonary anastomosis (b-BCPA) had a stormier postoperative course in respect to other patients with previous unilateral BCPA (u-BCPA) postoperatively after Fontan completion. Read More

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http://dx.doi.org/10.1177/2150135118819997DOI Listing
March 2019
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Spatial abilities training in anatomy education: A systematic review.

Anat Sci Educ 2019 Mar 6. Epub 2019 Mar 6.

School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.

Spatial abilities have been correlated to anatomy knowledge assessment and spatial training has been found to improve spatial abilities in previous systematic reviews. The objective of this systematic review was to evaluate spatial abilities training in anatomy education. A literature search was done from inception to 3 August 2017 in Scopus and several databases on the EBSCOhost platform. Read More

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http://dx.doi.org/10.1002/ase.1873DOI Listing