301,137 results match your criteria Heart Anatomy


Bone health in neuromyelitis optica: Bone mineral density and fractures.

Mult Scler Relat Disord 2020 Apr 28;42:102080. Epub 2020 Apr 28.

Department of Neurology, Seoul National University Bundang Hospital, Gyeonggi, Republic of Korea; Department of Neurology, Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: The bone health in neuromyelitis optica spectrum disorder with aquaporin-4 immunoglobulin G antibodies (NMOSD-AQP4) have not been fully evaluated. To evaluate the prevalence of fractures and bone loss in patients with NMOSD-AQP4 compared to healthy controls and patients with multiple sclerosis (MS) and to identify the risk factors associated with fractures and low bone mineral density (BMD) in patients with NMOSD-AQP4.

Methods: Seventy-one patients with NMOSD-AQP4 were included. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102080DOI Listing

Human adult cardiac autonomic innervation: Controversies in anatomical knowledge and relevance for cardiac neuromodulation.

Auton Neurosci 2020 May 16;227:102674. Epub 2020 May 16.

Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, the Netherlands; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.

Background: Cardiac sympathetic blockade is a therapeutic approach for arrhythmias and heart failure and may be a beneficial effect of high thoracic epidural anesthesia. These treatments require detailed knowledge of the spatial location and distribution of cardiac autonomic nerves, however, there are controversies on this subject in humans.

Objective: To provide a systematic overview of current knowledge on human anatomy of the cardiac autonomic nervous system. Read More

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http://dx.doi.org/10.1016/j.autneu.2020.102674DOI Listing

Ammonia exposure impairs lateral-line hair cells and mechanotransduction in zebrafish embryos.

Chemosphere 2020 May 27;257:127170. Epub 2020 May 27.

Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan. Electronic address:

Ammonia (including NH and NH) is a major pollutant of freshwater environments. However, the toxic effects of ammonia on the early stages of fish are not fully understood, and little is known about the effects on the sensory system. In this study, we hypothesized that ammonia exposure can cause adverse effects on embryonic development and impair the lateral line system of fish. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127170DOI Listing

Simultaneous left atrium anatomy and scar segmentations via deep learning in multiview information with attention.

Future Gener Comput Syst 2020 Jun;107:215-228

Cardiovascular Research Centre, Royal Brompton Hospital, SW3 6NP, London, UK.

Three-dimensional late gadolinium enhanced (LGE) cardiac MR (CMR) of left atrial scar in patients with atrial fibrillation (AF) has recently emerged as a promising technique to stratify patients, to guide ablation therapy and to predict treatment success. This requires a segmentation of the high intensity scar tissue and also a segmentation of the left atrium (LA) anatomy, the latter usually being derived from a separate bright-blood acquisition. Performing both segmentations automatically from a single 3D LGE CMR acquisition would eliminate the need for an additional acquisition and avoid subsequent registration issues. Read More

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http://dx.doi.org/10.1016/j.future.2020.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134530PMC

A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum.

Cell Rep 2020 Jun;31(9):107703

Fondazione Santa Lucia, IRCCS, Rome, Italy; Department of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, Rome, Italy. Electronic address:

Tight coordination of gene expression in the developing cerebellum is crucial for establishment of neuronal circuits governing motor and cognitive function. However, transcriptional changes alone do not explain all of the switches underlying neuronal differentiation. Here we unveiled a widespread and highly dynamic splicing program that affects synaptic genes in cerebellar neurons. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107703DOI Listing

Heart transplantation for recurrent Cutibacterium (Propionibacterium) acnes prosthetic heart valve endocarditis.

ANZ J Surg 2020 Jun 3. Epub 2020 Jun 3.

Green Lane Cardiothoracic Surgical Unit, Auckland City Hospital, Auckland, New Zealand.

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http://dx.doi.org/10.1111/ans.16024DOI Listing

Glossary of terms for musculoskeletal radiology.

Skeletal Radiol 2020 Jun 2. Epub 2020 Jun 2.

MRI Medical Radiological Institute, Zurich, Switzerland.

Members of the International Skeletal Society compiled a glossary of terms for musculoskeletal radiology. The authors also represent national radiology or pathology societies in Asia, Australia, Europe, and the USA. We provide brief descriptions of musculoskeletal structures, disease processes, and syndromes and address their imaging features. Read More

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http://dx.doi.org/10.1007/s00256-020-03465-1DOI Listing

The Human Leukocyte Antigen Locus and Rheumatic Heart Disease Susceptibility in South Asians and Europeans.

Sci Rep 2020 Jun 2;10(1):9004. Epub 2020 Jun 2.

The Wellcome Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, OX3 7BN, UK.

Rheumatic heart disease (RHD), an autoinflammatory heart disease, was recently declared a global health priority by the World Health Organization. Here we report a genome-wide association study (GWAS) of RHD susceptibility in 1,163 South Asians (672 cases; 491 controls) recruited in India and Fiji. We analysed directly obtained and imputed genotypes, and followed-up associated loci in 1,459 Europeans (150 cases; 1,309 controls) from the UK Biobank study. Read More

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http://dx.doi.org/10.1038/s41598-020-65855-8DOI Listing

Core functional nodes and sex-specific pathways in human ischaemic and dilated cardiomyopathy.

Nat Commun 2020 Jun 2;11(1):2843. Epub 2020 Jun 2.

Precision Cardiovascular Laboratory, The University of Sydney, Sydney, NSW, Australia.

Poor access to human left ventricular myocardium is a significant limitation in the study of heart failure (HF). Here, we utilise a carefully procured large human heart biobank of cryopreserved left ventricular myocardium to obtain direct molecular insights into ischaemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM), the most common causes of HF worldwide. We perform unbiased, deep proteomic and metabolomic analyses of 51 left ventricular (LV) samples from 44 cryopreserved human ICM and DCM hearts, compared to age-, gender-, and BMI-matched, histopathologically normal, donor controls. Read More

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http://dx.doi.org/10.1038/s41467-020-16584-zDOI Listing

Generation of human induced pluripotent stem cell line LUMCi027-A and its isogenic gene-corrected line from a patient affected by arrhythmogenic cardiomyopathy and carrying the c.2013delC PKP2 mutation.

Stem Cell Res 2020 May 5;46:101835. Epub 2020 May 5.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

Arrhythmogenic Cardiomyopathy (ACM) is a rare inherited heart muscle disease characterised by progressive fibro-fatty replacement of the ventricular myocardium leading to life-threatening arrhythmias. We generated human induced pluripotent stem cells (hiPSCs) from a patient affected by ACM and carrying the heterozygous c.2013delC (p. Read More

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http://dx.doi.org/10.1016/j.scr.2020.101835DOI Listing

Plectin dysfunction in neurons leads to tau accumulation on microtubules affecting neuritogenesis, organelle trafficking, pain sensitivity and memory.

Neuropathol Appl Neurobiol 2020 Jun 2. Epub 2020 Jun 2.

Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, University of Vienna, Vienna, Austria.

Aims: Plectin, a universally expressed multi-functional cytolinker protein, is crucial for intermediate filament networking, including crosstalk withactomyosin and microtubules. In addition to its involvement in a number of diseases affecting skin, skeletal muscle, heart, and other stress-exposed tissues, indications for a neuropathological role of plectin have emerged. Having identified P1c as the major isoform expressed in neural tissues in previous studies, our aim for the present work was to investigate whether, and by which mechanism(s), the targeted deletion of this isoform affects neuritogenesis and proper nerve cell functioning. Read More

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http://dx.doi.org/10.1111/nan.12635DOI Listing

Coexistence and outcome of coronary artery disease in Takotsubo syndrome.

Authors:
L Christian Napp Victoria L Cammann Milosz Jaguszewski Konrad A Szawan Manfred Wischnewsky Sebastiano Gili Maike Knorr Susanne Heiner Rodolfo Citro Eduardo Bossone Fabrizio D'Ascenzo Michael Neuhaus Jennifer Franke Ioana Sorici-Barb Michel Noutsias Christof Burgdorf Wolfgang Koenig Behrouz Kherad Annahita Sarcon Lawrence Rajan Guido Michels Roman Pfister Alessandro Cuneo Claudius Jacobshagen Mahir Karakas Alexander Pott Philippe Meyer Jose D Arroja Adrian Banning Florim Cuculi Richard Kobza Thomas A Fischer Tuija Vasankari K E Juhani Airaksinen Christian Hauck Carla Paolini Claudio Bilato Yoichi Imori Ken Kato Yoshio Kobayashi Grzegorz Opolski Monika Budnik Rafal Dworakowski Philip MacCarthy Christoph Kaiser Stefan Osswald Leonarda Galiuto Wolfgang Dichtl Christina Chan Paul Bridgman Daniel Beug Clément Delmas Olivier Lairez Ibrahim El-Battrawy Ibrahim Akin Ekaterina Gilyarova Alexandra Shilova Mikhail Gilyarov John D Horowitz Karolina Polednikova Petr Tousek Petr Widimský David E Winchester Jan Galuszka Christian Ukena Gregor Poglajen Pedro Carrilho-Ferreira Carlo Di Mario Abhiram Prasad Charanjit S Rihal P Christian Schulze Matteo Bianco Filippo Crea Martin Borggrefe Lars S Maier Fausto J Pinto Ruediger C Braun-Dullaeus Wolfgang Rottbauer Hugo A Katus Gerd Hasenfuß Carsten Tschöpe Burkert M Pieske Holger Thiele Heribert Schunkert Michael Böhm Stephan B Felix Thomas Münzel Jeroen J Bax Johann Bauersachs Eugene Braunwald Thomas F Lüscher Frank Ruschitzka Jelena R Ghadri Christian Templin

Eur Heart J 2020 Jun 2. Epub 2020 Jun 2.

University Heart Center, Department of Cardiology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland.

Aims: Takotsubo syndrome (TTS) is an acute heart failure syndrome, which shares many features with acute coronary syndrome (ACS). Although TTS was initially described with angiographically normal coronary arteries, smaller studies recently indicated a potential coexistence of coronary artery disease (CAD) in TTS patients. This study aimed to determine the coexistence, features, and prognostic role of CAD in a large cohort of patients with TTS. Read More

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http://dx.doi.org/10.1093/eurheartj/ehaa210DOI Listing

Highlights from Heart Rhythm 2018: Updates in Ventricular Tachycardia.

J Innov Card Rhythm Manag 2018 Sep 15;9(9):3336-3337. Epub 2018 Sep 15.

UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.19102/icrm.2018.090908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252674PMC
September 2018

Atrial Antitachycardia Pacing in Complex Congenital Heart Disease: A Case Series.

J Innov Card Rhythm Manag 2018 Mar 15;9(3):3079-3083. Epub 2018 Mar 15.

University of Iowa Carver College of Medicine, Iowa City, IA, USA.

Among the congenital heart disease (CHD) population, intra-atrial reentrant tachycardia (IART) is a common sequela resulting from anatomical anomalies and surgical scars that significantly increases morbidity and mortality. Atrial antitachycardia pacing (ATP) delivered by atrial antitachycardia devices (ATDs) has been used to treat IART in the CHD population. However, there remains limited data on the safety and efficacy of ATP, as well as on comparisons of its effects amongst different CHD subtypes. Read More

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http://dx.doi.org/10.19102/icrm.2018.090304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252767PMC

Characteristics and Outcomes of Patients Who Are Denied From a Percutaneous Edge-to-Edge Mitral Valve Repair After Being Referred to a Transcatheter Mitral Valve Program: Impact of a Dedicated Multidisciplinary Mitral Heart Team Approach.

J Invasive Cardiol 2020 Jun;32(6):E151-E157

Quebec Heart and Lung Institute, 2725 Chemin Sainte-Foy, Québec, Quebec, Canada G1V 4G5.

Background: Many patients referred for a MitraClip intervention are finally refused for this intervention, and data are very scarce on their outcomes. Our study sought to determine the characteristics and outcomes of patients who are referred to a mitral valve clinic and are finally denied from a percutaneous mitral edge-to-edge repair.

Methods: A total of 210 patients referred to our clinic for severe mitral regurgitation were retrospectively analyzed. Read More

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Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation.

Transl Neurodegener 2020 Jun 1;9(1):19. Epub 2020 Jun 1.

Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA, 30912, USA.

Mitochondrial dysfunction plays a central role in the formation of neuroinflammation and oxidative stress, which are important factors contributing to the development of brain disease. Ample evidence suggests mitochondria are a promising target for neuroprotection. Recently, methods targeting mitochondria have been considered as potential approaches for treatment of brain disease through the inhibition of inflammation and oxidative injury. Read More

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http://dx.doi.org/10.1186/s40035-020-00197-zDOI Listing

Cre/loxP approach-mediated downregulation of Pik3c3 inhibits the hypertrophic growth of renal proximal tubule cells.

J Cell Physiol 2020 May 31. Epub 2020 May 31.

Departments of Cellular Biology & Anatomy and Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia.

Nephron loss stimulates residual functioning nephrons to undergo compensatory growth. Excessive nephron growth may be a maladaptive response that sets the stage for progressive nephron damage, leading to kidney failure. To date, however, the mechanism of nephron growth remains incompletely understood. Read More

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http://dx.doi.org/10.1002/jcp.29811DOI Listing

Experimental Study of Heart Functionality during Treatment of Chronic Heart Failure in Rats of Different Age Groups with Levosimendan (Experimental Study).

Bull Exp Biol Med 2020 May 31. Epub 2020 May 31.

Department of Anatomy and Physiology of Humans and Animals, Institute of Biology and Chemistry, Moscow State Pedagogical University, Moscow, Russia.

Levosimendan is effective in the therapy of chronic heart failure in both mature and old rats, but the duration of its therapeutic effect differs in these age groups. In 15 days after treatment, the myocardium in old rats maintained augmented functionality, whereas in old animals, functional potencies returned to the levels observed prior to the therapy. Stimulation of tissue respiration with combined administration of L-carnitine and α-lipoic acid against the background of levosimendan treatment prolonged its therapeutic effect in mature, but not in old rats. Read More

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http://dx.doi.org/10.1007/s10517-020-04815-8DOI Listing

Transcatheter Aortic Valve Replacement in Bicuspid Versus Tricuspid Aortic Valves From the STS/ACC TVT Registry.

JACC Cardiovasc Interv 2020 May 23. Epub 2020 May 23.

Department of Cardiothoracic Surgery, Houston Methodist DeBakey Heart and Vascular Center, Houston, Texas.

Objectives: This study sought to compare outcomes in patients with bicuspid versus tricuspid anatomy undergoing transcatheter aortic valve replacement (TAVR).

Background: TAVR has shown excellent safety and efficacy in patients with tricuspid aortic valve stenosis, but limited data are available on the use of self-expanding valves in patients with bicuspid valves.

Methods: The Society of Thoracic Surgeons/American College of Cardiology TVT Registry was used to analyze patients who underwent TAVR with the Evolut R or Evolut PRO valves. Read More

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http://dx.doi.org/10.1016/j.jcin.2020.03.022DOI Listing

Tricuspid valve geometry in patients with functional tricuspid regurgitation: A three-dimensional echocardiographic study.

Echocardiography 2020 May 29. Epub 2020 May 29.

Heart Valve Disease Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Tricuspid valve (TV) has a complex anatomy causing some difficulties in echocardiographic evaluation. In this study, we sought to assess the geometry of TV in patients with functional tricuspid regurgitation (TR) by the implementation of 2- and 3-dimennsional (2D and 3D) echocardiography.

Methods: In a case-control study, the geometrical features of TV were evaluated in forty patients with functional TR using echocardiographic examinations, and those data compared with twenty-five age- and sex-matched healthy individuals. Read More

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http://dx.doi.org/10.1111/echo.14747DOI Listing

Heart failure in the adult Ebstein patient.

Heart Fail Rev 2020 May 29. Epub 2020 May 29.

Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, 870 Quarry Road - Falk CVRC, Stanford, CA, 94305-5406, USA.

Ebstein anomaly comprises approximately 1% of all congenital heart diseases. It occurs when the tricuspid valve fails to properly delaminate from the right ventricle, resulting in a clinical spectrum of abnormal tricuspid valve morphology and right ventricular dysfunction. Due to the anatomy of the tricuspid valve and right ventricle, as well as associated right- and left-sided pathology, patients are at risk for both right and left ventricular failure and the associated symptoms of each. Read More

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http://dx.doi.org/10.1007/s10741-020-09930-2DOI Listing

Disparities of demographics, clinical characteristics, and hospital outcomes of AMI pilgrims vs non-pilgrims-tertiary center experience.

Egypt Heart J 2020 May 29;72(1):31. Epub 2020 May 29.

King Abdullah Medical City, Muzdallfa Road, Makkah, Saudi Arabia.

Background: Acute myocardial infarction (AMI) is usually caused by rupture of an atherosclerotic plaque leading to thrombotic occlusion of a coronary artery. Cardiovascular disease has recently emerged as the leading cause of death during hajj. Our aim is to demonstrate the AMI pilgrim's related disparities and comparing them to non-pilgrim patients. Read More

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http://dx.doi.org/10.1186/s43044-020-00068-yDOI Listing

Central Vascular Thrombosis in Neonates with Congenital Heart Disease Awaiting Cardiac Intervention.

Pediatr Cardiol 2020 May 29. Epub 2020 May 29.

Division of Pediatric and Congenital Heart Surgery, Department of Surgery, Augusta University, Augusta, GA, USA.

Central vascular thrombosis (CVT) in critically ill neonates carries significant clinical implications. Neonates with congenital heart disease (CHD) awaiting cardiac intervention might be associated with increased risk of thrombosis. Outcome analysis was undertaken. Read More

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http://dx.doi.org/10.1007/s00246-020-02383-2DOI Listing

Microstructural changes in the trigeminal nerve of patients with episodic migraine assessed using magnetic resonance imaging.

J Headache Pain 2020 May 29;21(1):59. Epub 2020 May 29.

Department of Anatomy and Histology, F13, University of Sydney, Sydney, NSW, 2006, Australia.

Background: There is histological evidence of microstructural changes in the zygomaticotemporal branch of the trigeminal nerve in migraineurs. This raises the possibility that altered trigeminal nerve properties contribute to migraine pathophysiology. Whilst it is not possible to explore the anatomy of small trigeminal nerve branches it is possible to explore the anatomy of the trigeminal root entry zone using magnetic resonance imaging in humans. Read More

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http://dx.doi.org/10.1186/s10194-020-01126-1DOI Listing

Double balloon technique for retrograde venous ethanol ablation of ventricular arrhythmias in the absence of suitable intramural veins.

Heart Rhythm 2020 May 26. Epub 2020 May 26.

Division of Cardiac Electrophysiology, Department of Cardiology, Houston Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital, Houston, Texas,. Electronic address:

Background: Venous ethanol infusion via an occlusive balloon has been utilized as bail-out approach to treat ablation-refractory ventricular arrhythmias (VA). Unfavorable venous anatomy - lack of intramural veins at the targeted site or collateral vein-ethanol shunting- limits its efficacy. Blocking collateral flow with a second balloon may optimize myocardial ethanol delivery. Read More

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http://dx.doi.org/10.1016/j.hrthm.2020.05.027DOI Listing

Perspectives on surgical treatment of mitral valve disease.

Authors:
Tirone E David

Asian Cardiovasc Thorac Ann 2020 May 29:218492320930846. Epub 2020 May 29.

Division of Cardiovascular Surgery of Peter Munk Cardiac Centre at Toronto General Hospital and the University of Toronto, Toronto, Ontario, Canada.

A sound knowledge of the functional anatomy of the mitral valve and the alterations caused by different diseases is indispensable for surgeons treating patients with mitral valve disease. Rheumatic mitral valve disease remains the most common heart valvular disorder in developing countries, whereas mitral regurgitation due myxomatous degeneration of the valve is the most common in developed countries. The mitral valve should be repaired whenever possible, as long as the outcome is predictably better than that of replacement. Read More

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http://dx.doi.org/10.1177/0218492320930846DOI Listing

MiR-126a-5p limits the formation of abdominal aortic aneurysm in mice and decreases ADAMTS-4 expression.

J Cell Mol Med 2020 May 29. Epub 2020 May 29.

Vascular Surgery Research Laboratories, Division of Vascular and Endovascular Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Abdominal aortic aneurysm (AAA) is a serious vascular disease featured by inflammatory infiltration in aortic wall, aortic dilatation and extracellular matrix (ECM) degradation. Dysregulation of microRNAs (miRNAs) is implicated in AAA progress. By profiling miRNA expression in mouse AAA tissues and control aortas, we noted that miR-126a-5p was down-regulated by 18-fold in AAA samples, which was further validated with real-time qPCR. Read More

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http://dx.doi.org/10.1111/jcmm.15422DOI Listing

Nck1, But Not Nck2, Mediates Disturbed Flow-Induced p21-Activated Kinase Activation and Endothelial Permeability.

J Am Heart Assoc 2020 Jun 29;9(11):e016099. Epub 2020 May 29.

Department of Pathology and Translational Pathobiology LSU Health-Shreveport LA.

Background Alteration in hemodynamic shear stress at atheroprone sites promotes endothelial paracellular pore formation and permeability. The molecular mechanism remains unknown. Methods and Results We show that Nck (noncatalytic region of tyrosine kinase) deletion significantly ameliorates disturbed flow-induced permeability, and selective isoform depletion suggests distinct signaling mechanisms. Read More

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http://dx.doi.org/10.1161/JAHA.120.016099DOI Listing

Toxicity of palm oil mill effluent on the early life stages of Nile tilapia (Oreochromis niloticus, Linnaeus 1758).

Environ Sci Pollut Res Int 2020 May 28. Epub 2020 May 28.

Global Centre for Environmental Remediation (GCER), Faculty of Science, The University of Newcastle, Callaghan, NSW, 2308, Australia.

Harmful effects of several pollutants have been reported on early life stages of fish. However, the effects of palm oil mill effluent (POME) on fish early life stages are still unexplored. Therefore, the objective of this present study was to elucidate the impact of POME on the early life stages of Nile tilapia (Oreochromis niloticus). Read More

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http://dx.doi.org/10.1007/s11356-020-09410-yDOI Listing

Self-Maintenance of Cardiac Resident Reparative Macrophages Attenuates Doxorubicin-induced Cardiomyopathy Through the SR-A1-c-Myc Axis.

Circ Res 2020 May 29. Epub 2020 May 29.

Atherosclerosis Research Center, Nanjing Medical University, CHINA.

Doxorubicin-induced cardiomyopathy (DiCM) is a primary cause of heart failure and mortality in cancer patients, in which macrophage-orchestrated inflammation serves as an essential pathological mechanism. However, the specific roles of tissue-resident and monocyte-derived macrophages in DiCM remain poorly understood. Uncovering the origins, phenotypes, and functions of proliferative cardiac resident macrophages and mechanistic insights into the self-maintenance of cardiac macrophage during DiCM progression. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.119.316428DOI Listing
May 2020
11.019 Impact Factor

Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy following Ischemic Brain Injury.

Int J Mol Sci 2020 May 26;21(11). Epub 2020 May 26.

Department of Emergency Medicine, Emory University, Atlanta, GA 30322, USA.

NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome inhibition and autophagy induction attenuate inflammation and improve outcome in rodent models of cerebral ischemia. However, the impact of chronic stress on NLRP3 inflammasome and autophagic response to ischemia remains unknown. Progesterone (PROG), a neuroprotective steroid, shows promise in reducing excessive inflammation associated with poor outcome in ischemic brain injury patients with comorbid conditions, including elevated stress. Read More

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http://dx.doi.org/10.3390/ijms21113740DOI Listing

Platypnea Orthodeoxia Syndrome Secondary to Intracardiac Shunt Following Orthotopic Liver Transplantation.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620925575

University of Washington, Seattle, WA, USA.

Platypnea orthodeoxia syndrome (POS) occurs when an upright position results in acute-onset hypoxemia and is relieved with recumbency. POS can be due to intracardiac shunting, intrapulmonary shunting, ventilation-perfusion mismatch, or a combination of these. We report a case of POS that developed 3 days post liver transplantation as a result of new-onset right to left shunting across a patent foramen ovale. Read More

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http://dx.doi.org/10.1177/2324709620925575DOI Listing

Hesperidin ameliorates signs of the metabolic syndrome and cardiac dysfunction via IRS/Akt/GLUT4 signaling pathway in a rat model of diet-induced metabolic syndrome.

Eur J Nutr 2020 May 27. Epub 2020 May 27.

Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.

Background: Hesperidin has been reported to have biological activities such as antihypertensive, hypoglycemic, and antioxidant effects. This study investigated whether hesperidin could improve signs of the metabolic syndrome and cardiac function in a high-fat diet (HFD) induced metabolic syndrome (MS) in rats.

Methods: Male Sprague-Dawley rats were fed HFD and 15% fructose for 16 weeks and treated with hesperidin (15 or 30 mg/kg, based on signs of MS from a preliminary study) or metformin, a positive control agent, (100 mg/kg) for the final four weeks. Read More

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http://dx.doi.org/10.1007/s00394-020-02291-4DOI Listing

A Rare Access Site Complication after Transcatheter Aortic Valve Implantation.

J Tehran Heart Cent 2019 Oct;14(4):187-190

Department of Cardiology, Medical Park Izmir Hospital, İzmir, Turkey.

In the majority of patients undergoing transcatheter aortic valve implantation, the transfemoral access is the suggested approach due to its less invasive nature and feasibility in patients with suitable vascular anatomy. The complications of the transfemoral access site are generally vascular; however, we herein present a rare case of colon perforation following the transfemoral procedure owing to prior abdominal surgery. A transfemoral aortic valve was inserted on account of severe aortic stenosis and a high probability of surgical mortality. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231681PMC
October 2019

Consensus Statement on Proton Therapy in Mesothelioma.

Pract Radiat Oncol 2020 May 24. Epub 2020 May 24.

Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA.

Radiation therapy for mesothelioma remains challenging, as normal tissue toxicity limits the amount of radiation that can be safely delivered to the pleural surfaces, especially radiation dose to the contralateral lung. The physical properties of proton therapy result in better sparing of normal tissues when treating the pleura, both in the post-pneumonectomy setting and the lung-intact setting. Compared to photon radiation, there are dramatic reductions in dose to the contralateral lung, heart, liver, kidneys, and stomach. Read More

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http://dx.doi.org/10.1016/j.prro.2020.05.004DOI Listing

A Comprehensive Integrated Anatomical and Molecular Atlas of Rat Intrinsic Cardiac Nervous System.

iScience 2020 May 23:101140. Epub 2020 May 23.

Daniel Baugh Institute for Functional Genomics/Computational Biology, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:

We have developed and integrated several technologies including whole-organ imaging and software development to support an initial precise 3D neuroanatomical mapping and molecular phenotyping of the intracardiac nervous system (ICN). While qualitative and gross anatomical descriptions of the anatomy of the ICN have each been pursued, we here bring forth a comprehensive atlas of the entire rat ICN at single-cell resolution. Our work precisely integrates anatomical and molecular data in the 3D digitally reconstructed whole heart with resolution at the micron scale. Read More

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http://dx.doi.org/10.1016/j.isci.2020.101140DOI Listing

Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease.

Cell Stem Cell 2020 May 20. Epub 2020 May 20.

Department of Anatomy and Embryology, Leiden University Medical Center, 2333 Leiden, the Netherlands; Department of Applied Stem Cell Technologies, University of Twente, 7500 Enschede, the Netherlands. Electronic address:

Cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) are functionally immature, but this is improved by incorporation into engineered tissues or forced contraction. Here, we showed that tri-cellular combinations of hiPSC-derived CMs, cardiac fibroblasts (CFs), and cardiac endothelial cells also enhance maturation in easily constructed, scaffold-free, three-dimensional microtissues (MTs). hiPSC-CMs in MTs with CFs showed improved sarcomeric structures with T-tubules, enhanced contractility, and mitochondrial respiration and were electrophysiologically more mature than MTs without CFs. Read More

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http://dx.doi.org/10.1016/j.stem.2020.05.004DOI Listing

Constructing a Human Atrial Fibre Atlas.

Ann Biomed Eng 2020 May 26. Epub 2020 May 26.

School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.

Atrial anisotropy affects electrical propagation patterns, anchor locations of atrial reentrant drivers, and atrial mechanics. However, patient-specific atrial fibre fields and anisotropy measurements are not currently available, and consequently assigning fibre fields to atrial models is challenging. We aimed to construct an atrial fibre atlas from a high-resolution DTMRI dataset that optimally reproduces electrophysiology simulation predictions corresponding to patient-specific fibre fields, and to develop a methodology for automatically assigning fibres to patient-specific anatomies. Read More

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http://dx.doi.org/10.1007/s10439-020-02525-wDOI Listing

The Effect of Exercise Training During Pregnancy to Improve Maternal Vascular Health: Focus on Gestational Hypertensive Disorders.

Front Physiol 2020 8;11:450. Epub 2020 May 8.

Research Group Cardiovascular Diseases, Department of Genetics, Pharmacology and Physiopathology of Heart, Blood Vessels and Skeleton, University of Antwerp, Antwerp, Belgium.

Hypertensive disorders of pregnancy, including gestational hypertension and pre-eclampsia, occur in up to 10% of pregnancies and are associated with increased life-long cardiovascular risk. Physical activity improves cardiovascular health in pregnancy and may lower the risk of developing hypertensive disorders of pregnancy. However, a minority of pregnant women comply with the recommended level of physical activity. Read More

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http://dx.doi.org/10.3389/fphys.2020.00450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225346PMC

Preventive Effects of Neuroprotective Agents in a Neonatal Rat of Photothrombotic Stroke Model.

Int J Mol Sci 2020 May 24;21(10). Epub 2020 May 24.

Department of Medical Science, Chungnam National University, Daejeon 35015, Korea.

Neonatal ischemic stroke has a higher incidence than childhood stroke. Seizures are the first sign for the need for clinical assessment in neonates, but many questions remain regarding treatments and follow-up modalities. In the absence of a known pathophysiological mechanism, only supportive care is currently provided. Read More

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http://dx.doi.org/10.3390/ijms21103703DOI Listing

Transforming Growth Factor Beta3 is Required for Cardiovascular Development.

J Cardiovasc Dev Dis 2020 May 24;7(2). Epub 2020 May 24.

Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29209, USA.

Transforming growth factor beta3 () gene mutations in patients of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD1) and Loeys-Dietz syndrome-5 (LDS5)/Rienhoff syndrome are associated with cardiomyopathy, cardiac arrhythmia, cardiac fibrosis, cleft palate, aortic aneurysms, and valvular heart disease. Although the developing heart of embryos express , its overarching role remains unclear in cardiovascular development and disease. We used histological, immunohistochemical, and molecular analyses of fetuses and compared them to wildtype littermate controls. Read More

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http://dx.doi.org/10.3390/jcdd7020019DOI Listing

The preventive strategy for pandemics in the elderly is to collect in advance samples & data to counteract chronic inflammation (inflammaging).

Ageing Res Rev 2020 May 23:101091. Epub 2020 May 23.

Rostock University Medical Center, Institute for Clinical Chemistry and Laboratory Medicine, Rostock, Germany; Institute of Laboratory Medicine, Clinical Chemistry, and Pathobiochemistry, Charité University Medical Center, Berlin, Germany. Electronic address:

Fighting the current COVID-19 pandemic, we must not forget to prepare for the next. Since elderly and frail people are at high risk, we wish to predict their vulnerability, and intervene if possible. For example, it would take little effort to take additional swabs or dried blood spots. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245683PMC

Cardiogenic shock: role of invasive cardiology.

Curr Opin Crit Care 2020 May 20. Epub 2020 May 20.

Department of Internal Medicine/Cardiology, Heart Center Leipzig at the University of Leipzig and Leipzig Heart Institute, Leipzig, Germany.

Purpose Of Review: Early revascularization significantly improved the outcome of patients with cardiogenic shock following acute myocardial infarction (AMI). Nevertheless, the mortality remains substantial, ranging between 40 and 50% after 30 days. The present review summarizes the current evidence regarding revascularization strategies, vascular access site and concomitant antiplatelet and antithrombotic treatment in infarct-related cardiogenic shock. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000738DOI Listing

Balloon-Assisted Ultrasound-Guided Percutaneous Thrombin Injection of Iatrogenic Femoral Artery Pseudoaneurysms: A Case Report and Description of the Technique.

Vasc Endovascular Surg 2020 May 26:1538574420927861. Epub 2020 May 26.

Department of Cardiovascular Surgery, Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, TX, USA.

Ultrasound-guided thrombin injection (UGTI) has emerged as the first-line treatment for moderately sized or persistent pseudoaneurysms (PSAs). Although rare, the most feared complication of UGTI is arterial thrombosis or embolism during the off-label injection of thrombin causing acute limb ischemia requiring emergent surgical intervention. Higher thrombin volume, rapidity of injection, and wide or short-neck PSAs are all thought to increase the risk of arterial thrombosis or embolism during this procedure. Read More

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http://dx.doi.org/10.1177/1538574420927861DOI Listing

COVID-19: Stroke Admissions, Emergency Department Visits, and Prevention Clinic Referrals.

Can J Neurol Sci 2020 May 26:1-10. Epub 2020 May 26.

Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.

We assessed the impact of the coronavirus disease 19 (COVID-19) pandemic on code stroke activations in the ED, stroke unit admissions, and referrals to the stroke prevention clinic at London's regional stroke center, serving a population of 1.8 million in Ontario, Canada. We found a 20% drop in the number of code strokes in 2020 compared to 2019, immediately after the first cases of COVID-19 were officially confirmed. Read More

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http://dx.doi.org/10.1017/cjn.2020.101DOI Listing

Tetralogy of Fallot With Pulmonary Atresia: Anatomy, Physiology, Imaging, and Perioperative Management.

Semin Cardiothorac Vasc Anesth 2020 May 26:1089253220920480. Epub 2020 May 26.

Seattle Children's Hospital, Seattle, WA, USA.

Tetralogy of Fallot (ToF) with pulmonary atresia (ToF-PA) is a complex congenital heart defect at the extreme end of the spectrum of ToF, with no antegrade flow into the pulmonary arteries. Patients differ with regard to the sources of pulmonary blood flow. In the milder spectrum of disease, there are confluent branch pulmonary arteries fed by ductus arteriosus. Read More

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http://dx.doi.org/10.1177/1089253220920480DOI Listing

Propranolol is an effective topical and systemic treatment option for experimental epidermolysis bullosa acquisita.

J Invest Dermatol 2020 May 22. Epub 2020 May 22.

Lübeck Institute of Experimental Dermatology, University of Lübeck, Germany. Electronic address:

Propranolol is a ß-adrenoreceptor type 2 (ADRB2) blocker that regulates heart muscle contractions, smooth muscle relaxation and glycogenolysis. In addition, an increasing number of applications in dermatology have been described; most prominently, the use as a first-line treatment for infantile hemangiomas. We here show that propranolol enhances IL-8-induced neutrophil chemotaxis and reduces the release of reactive oxygen species (ROS) after immune complex (IC) stimulation. Read More

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http://dx.doi.org/10.1016/j.jid.2020.04.025DOI Listing