324,229 results match your criteria Heart Anatomy

Non-linear shrinkage of Batson's #17 resin during vascular corrosion casting.

J Anat 2022 Jun 25. Epub 2022 Jun 25.

Department of Bioengineering, Imperial College London, South Kensington Campus, London, UK.

Many studies of cardiovascular function require a realistic representation of vascular geometry. Corrosion casting has been used to acquire such geometries for many decades. However, the fidelity with which this method reproduces vascular anatomy has not been completely determined. Read More

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Can Blebbistatin block the hypertrophy status in the zebrafish exvivo cardiac model?

Biochim Biophys Acta Mol Basis Dis 2022 Jun 21:166471. Epub 2022 Jun 21.

Department of Ecological and Biological Sciences, Tuscia University, Viterbo, Italy. Electronic address:

Ex-vivo simple models are powered tools to study cardiac hypertrophy. It is possible to control the activation of critical genes and thus test the effects of drug therapies before the in vivo tests. A zebrafish cardiac hypertrophy developed by 500 μM phenylephrine (PE) treatment in ex vivo culture has been demonstrated to activate the essential expression of the embryonal genes. Read More

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Demonstration of Use of a Novel 3D Printed Simulator for Mitral Valve Transcatheter Edge-to-Edge Repair (TEER).

Materials (Basel) 2022 Jun 17;15(12). Epub 2022 Jun 17.

Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK.

Mitral regurgitation is a common valvular disorder. Transcatheter edge-to-edge repair (TEER) is a minimally invasive technique which involves holding together the middle segments of the mitral valve leaflets, thereby reducing regurgitation. To date, MitraClip™ is the only Food and Drug Administration (FDA)-approved device for TEER. Read More

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CardioNet: Automatic Semantic Segmentation to Calculate the Cardiothoracic Ratio for Cardiomegaly and Other Chest Diseases.

J Pers Med 2022 Jun 17;12(6). Epub 2022 Jun 17.

Department of Unmanned Vehicle Engineering, Sejong University, Seoul 05006, Korea.

Semantic segmentation for diagnosing chest-related diseases like cardiomegaly, emphysema, pleural effusions, and pneumothorax is a critical yet understudied tool for identifying the chest anatomy. A dangerous disease among these is cardiomegaly, in which sudden death is a high risk. An expert medical practitioner can diagnose cardiomegaly early using a chest radiograph (CXR). Read More

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Inversion of Left Atrial Appendage Will Cause Compressive Stresses in the Tissue: Simulation Study of Potential Therapy.

J Pers Med 2022 May 27;12(6). Epub 2022 May 27.

California Medical Innovations Institute, 11107 Roselle, San Diego, CA 92121, USA.

In atrial fibrillation (AF), thromboembolic events can result from the particular conformation of the left atrial appendage (LAA) bearing increased clot formation and accumulation. Current therapies to reduce the risk of adverse events rely on surgical exclusion or percutaneous occlusion, each of which has drawbacks limiting application and efficacy. We sought to quantify the hemodynamic and structural loads of a novel potential procedure to partially invert the "dead" LAA space to eliminate the auricle apex where clots develop. Read More

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Age and Chronodisruption in Mouse Heart: Effect of the NLRP3 Inflammasome and Melatonin Therapy.

Int J Mol Sci 2022 Jun 20;23(12). Epub 2022 Jun 20.

Departamento de Fisiología, Facultad de Medicina, Instituto de Biotecnología, Centro de Investigación Biomédica, Parque Tecnológico de Ciencias de la Salud, Universidad de Granada, 18016 Granada, Spain.

Age and age-dependent inflammation are two main risk factors for cardiovascular diseases. Aging can also affect clock gene-related impairments such as chronodisruption and has been linked to a decline in melatonin synthesis and aggravation of the NF-κB/NLRP3 innate immune response known as inflammaging. The molecular drivers of these mechanisms remain unknown. Read More

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Coexistence of Cor Triatriatum Sinister, Fibroelastoma and Pulmonary Veins Ostial Anatomy Variant as Incidental Findings in Coronary Computed Tomography Angiography.

Diagnostics (Basel) 2022 Jun 13;12(6). Epub 2022 Jun 13.

Department of Internal and Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, Borowska 213, PL 50-556 Wroclaw, Poland.

Coronary computed tomography angiography (CCTA) is a noninvasive examination whose main purpose is to exclude significant stenosis in the coronary arteries. The obtained computed tomography images may also provide information about other coexisting pathologies of the heart and vessels. The paper presents images of cardiac lesions in a 44-year-old hypertensive patient who underwent CCTA, based on which significant stenosis in the coronary arteries was excluded, the suspicion of a cor triatriatum sinister was confirmed and the presence of fibroelastoma and a variant of the anatomy of the pulmonary veins ostial was confirmed. Read More

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Our Experience in Using the Endovascular Therapy in the Management of Hemorrhages in Obstetrics and Gynecology.

Diagnostics (Basel) 2022 Jun 10;12(6). Epub 2022 Jun 10.

Department of Obstetrics and Gynaecology, University Emergency Hospital Bucharest, 050098 Bucharest, Romania.

(1) Background: A quarter of maternal deaths are caused by post-partum hemorrhage; hence obstetric bleeding is a significant cause of morbidity and mortality among women. Pelvic artery embolization (PAE) represents a minimally invasive interventional procedure which plays an important role in conservative management of significant bleeding in Obstetrics and Gynecology. The aim of this study was to evaluate the effect and the complications of PAE in patients with significant vaginal bleeding with different obstetrical and gynecological pathologies. Read More

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Tumor Necrosis Factor Receptor Superfamily Member 21 Induces Endothelial-Mesenchymal Transition in Coronary Artery Endothelium of Type 2 Diabetes Mellitus.

Biomedicines 2022 May 30;10(6). Epub 2022 May 30.

Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Diabetes mellitus (DM) is an increasing threat to human health and regarded as an important public issue. Coronary artery disease is one of the main causes of death in type 2 DM patients. However, the effect of hyperglycemia on coronary artery endothelial cells (CAECs) and the pathophysiologic mechanisms are still not well-explored. Read More

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Biochemical Discrimination of the Down Syndrome-Related Metabolic and Oxidative/Nitrosative Stress Alterations from the Physiologic Age-Related Changes through the Targeted Metabolomic Analysis of Serum.

Antioxidants (Basel) 2022 Jun 20;11(6). Epub 2022 Jun 20.

Department of Geriatric and Orthopedic Sciences, Catholic University of Rome, Largo Francesco Vito, 1, 00168 Rome, Italy.

Down Syndrome (DS) is a neurodevelopmental disorder that is characterized by an accelerated aging process, frequently associated with the development of Alzheimer's disease (AD). Previous studies evidenced that DS patients have various metabolic anomalies, easily measurable in their serum samples, although values that were found in DS patients were compared with those of age-matched non-DS patients, thus hampering to discriminate the physiologic age-related changes of serum metabolites from those that are truly caused by the pathologic processes associated with DS. In the present study we performed a targeted metabolomic evaluation of serum samples from DS patients without dementia of two age classes (Younger DS Patients, YDSP, aging 20-40 years; Aged DS Patients, ADSP, aging 41-60 years), comparing the results with those that were obtained in two age classes of non-DS patients (Younger non-DS Patients, YnonDSP, aging 30-60 years; Aged-nonDS Patients, AnonDSP, aging 75-90 years). Read More

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Evaluation of classifications of the monopodial bronchopulmonary vasculature using clustering methods.

Histochem Cell Biol 2022 Jun 23. Epub 2022 Jun 23.

Institute of Functional and Applied Anatomy, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Mammalian pulmonary arteries divide multiple times before reaching the vast capillary network of the alveoli. Morphological analyses of the arterial branches can be challenging because more proximal branches are likely biologically distinct from more peripheral parts. Thus, it is useful to group the arterial branches into groups of coherent biology. Read More

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The role of mechanical valves in the aortic position in the era of bioprostheses and TAVR: Evidence-based appraisal and focus on the On-X valve.

Prog Cardiovasc Dis 2022 Jun 20. Epub 2022 Jun 20.

Department of Cardiothoracic Surgery, Franciscan Health, Indianapolis, IN, United States of America.

Patients who need a prosthetic aortic heart valve may decide, working with their cardiologist and cardiac surgeon, among a variety of options: surgical or transcatheter approach, bioprosthetic or mechanical valve, or a Ross procedure if suitable to their age and anatomy. This review article examines the evidence for survival benefit with mechanical aortic valves, discusses bioprosthetic structural valve degeneration and its consequences, and considers the risks of redo aortic valve surgery or subsequent valve-in-valve (ViV) transcatheter intervention. It highlights the unique characteristics of the On-X aortic valve, including the US Food and Drug Administration approved and American College of Cardiology/American Heart Association guideline supported reduced anticoagulation target INR of 1. Read More

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β-Lapachone, an NQO1 activator, alleviates diabetic cardiomyopathy by regulating antioxidant ability and mitochondrial function.

Phytomedicine 2022 Jun 6;104:154255. Epub 2022 Jun 6.

Graduate Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University. Electronic address:

Background: Diabetic cardiomyopathy (DC) is one of the major lethal complications in patients with diabetes mellitus (DM); however, no specific strategy for preventing or treating DC has been identified.

Purpose: This study aimed to investigate the effects of β-lapachone (Lap), a natural compound that increases antioxidant activity in various tissues, on DC and explore the underlying mechanisms.

Study Design And Methods: As an in vivo model, C57BL/6 mice were fed with the high-fat diet (HF) for 10 weeks to induce type 2 DM. Read More

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Quantitative mapping of force-pCa curves to whole heart contraction and relaxation.

J Physiol 2022 Jun 23. Epub 2022 Jun 23.

Cardiac Electromechanics Research Group, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.

Key Points: The force-pCa (F-pCa) curve is used to assess myofilament calcium sensitivity following pharmacological modulation and to infer pharmacological effects on whole-heart function. We demonstrate that there is a non-unique mapping from changes in F-pCa curves and changes in left ventricle (LV) function. The effect of changes in F-pCa on LV function depend on the state of the heart and could be different for different pathological conditions. Read More

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When Does the Human Embryonic Heart Start Beating? A Review of Contemporary and Historical Sources of Knowledge about the Onset of Blood Circulation in Man.

Jörg Männer

J Cardiovasc Dev Dis 2022 Jun 9;9(6). Epub 2022 Jun 9.

Group Cardio-Embryology, Institute of Anatomy and Embryology UMG, Georg-August-University Goettingen, D-37075 Goettingen, Germany.

The onset of embryonic heart beating may be regarded as the defining feature for the beginning of personal human life. Clarifying the timing of the first human heartbeat, therefore, has religious, philosophical, ethical, and medicolegal implications. This article reviews the historical and contemporary sources of knowledge on the beginning of human heart activity. Read More

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Extra-Pleural Pneumonectomy (EPP) in Children and Adults with Locally Advanced Sarcoma: A CanSaRCC Study.

Curr Oncol 2022 Jun 15;29(6):4260-4266. Epub 2022 Jun 15.

Division of Medical Oncology, Canadian Sarcoma Research and Clinical Collaboration (CanSaRCC), Princess Margaret Cancer Centre-University Health Network, Toronto, ON M5G 2C1, Canada.

Sarcoma can present as locally advanced disease involving pleura for which extra-pleural pneumonectomy (EPP) may be the only surgical option to ensure adequate local control. Data were collected on patients who underwent EPP between January 2009 and August 2021 at Princess Margret Hospital and SickKids (Toronto) using the CanSaRCC (Canadian Sarcoma Research and Clinical Collaboration). Ten patients with locally advanced sarcoma involving the pleura, aged 4 to 59 years (median 19. Read More

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An infant phantom for pediatric pericardial access and electrophysiology training.

Heart Rhythm O2 2022 Jun 22;3(3):295-301. Epub 2022 Feb 22.

Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC.

Background: Cardiac procedures in infants and children require a high level of skill and dexterity owing to small stature and anatomy. Lower incidence of procedure volume in this population results in fewer clinical opportunities for learning. Simulators have grown in popularity for education and training, though most existing simulators are often cost-prohibitive or model adult anatomy. Read More

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Tricuspid Valve Prolapse: An Uncommon Pathology Revealed by TEE.

Methodist Debakey Cardiovasc J 2022 3;18(3):87-88. Epub 2022 Jun 3.

Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, US.

A 73-year-old male with a history of dilated cardiomyopathy and paroxysmal atrial fibrillation underwent transthoracic echocardiography (TTE) to evaluate for endocarditis due to fever and gram-positive cocci in chains on blood cultures. TTE revealed a 3 × 8 mm mass on the ventricular aspect of the tricuspid valve ( ). Subsequent transesophageal echocardiography (TEE) showed that the mass in question was actually myxomatous degeneration of the tricuspid valve (TV) and redundant chordae with significant valve prolapse. Read More

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Post-infarction ventricular septal rupture.

Tirone E David

Ann Cardiothorac Surg 2022 May;11(3):261-267

Division of Cardiac Surgery of the Peter Munk Cardiac Centre at Toronto General Hospital and the University of Toronto, Toronto, Ontario, Canada.

Coronary reperfusion therapies have led to a reduction in the incidence of mechanical complications of acute myocardial infarction (AMI), but the associated mortality of these complications has remained high. Ventricular septal rupture is the most common mechanical complication after myocardial infarction and occurs in approximately 0.21% with ST-segment elevation myocardial infarction and in 0. Read More

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Treatment Strategies and Outcomes of Emergency Left Main Percutaneous Coronary Intervention.

Am J Cardiol 2022 Jun 19. Epub 2022 Jun 19.

Department of Cardiology, Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom; Institute of Cardiovascular Sciences, University College London, London, United Kingdom.

Emergency percutaneous coronary intervention of the left main (LM ePCI) coronary artery necessitated by acute coronary syndrome is associated with a high risk of mortality. However, optimal treatment strategies and related outcomes remain undefined in this group. We undertook a multi-center, retrospective, observational cohort study of consecutive patients requiring LM ePCI between 2011 and 2018 and reported the coronary anatomy, treatment strategies, outcomes, and predictors of mortality. Read More

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Loss of Amphiregulin drives inflammation and endothelial apoptosis in pulmonary hypertension.

Life Sci Alliance 2022 Nov 22;5(11). Epub 2022 Jun 22.

Division of Cardiology, Department of Medicine, Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

Pulmonary hypertension (PH) is a vascular disease characterized by elevated pulmonary arterial pressure, leading to right ventricular failure and death. Pathogenic features of PH include endothelial apoptosis and vascular inflammation, which drive vascular remodeling and increased pulmonary arterial pressure. Re-analysis of the whole transcriptome sequencing comparing human pulmonary arterial endothelial cells (PAECs) isolated from PH and control patients identified , which encodes Amphiregulin, as a key endothelial survival factor. Read More

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November 2022

Prenatal diagnosis of a coronary-to-pulmonary artery fistula in a fetus with pulmonary atresia and ventricular septal defect.

BMJ Case Rep 2022 Jun 22;15(6). Epub 2022 Jun 22.

Department of Pediatrics, School of Medicine Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.

Pulmonary atresia and ventricular septal defect (PA/VSD) demonstrate a wide variety of pulmonary and coronary artery abnormalities; additionally, coronary-to-pulmonary artery fistula (CPAF) is a rare manifestation of PA/VSD and is seldom detected during pregnancy. In this report, we present a case of prenatal diagnosis of CPAF in PA/VSD and impactful images in a neonate, which were obtained using fetal echocardiography and postnatal electrocardiography-gated 320-row CT. Prenatal diagnosis of CPAF can facilitate the provision of better therapeutic strategies after birth. Read More

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Rivaroxaban and Risk of Venous Thromboembolism in Patients With Symptomatic Peripheral Artery Disease After Lower Extremity Revascularization.

JAMA Netw Open 2022 Jun 1;5(6):e2215580. Epub 2022 Jun 1.

Division of Cardiology, Department of Medicine, University of Colorado School of Medicine, Aurora.

Importance: Prior studies have observed an association between the burden of atherosclerotic vascular disease and the risk of venous thromboembolism (VTE). The association is not well described in peripheral artery disease (PAD) after lower extremity revascularization (LER).

Objective: To describe the risk of, factors associated with, and outcomes after VTE, as well as the association of low-dose rivaroxaban plus antiplatelet therapy with VTE after LER. Read More

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Safety and Efficacy of SSRIs in Improving Poststroke Recovery: A Systematic Review and Meta-Analysis.

J Am Heart Assoc 2022 Jun 22:e025868. Epub 2022 Jun 22.

Faculty of Medicine Jordan University of Science and Technology Irbid Jordan.

Background Several studies investigated the role of selective serotonin reuptake inhibitors (SSRIs) in improving poststroke recovery; thus, we have decided to conduct this systematic review and meta-analysis to investigate the efficacy and safety of SSRIs in poststroke recovery. Methods and Results In this meta-analysis we searched the following databases: PubMed, Cochrane, Scopus, and Google Scholar. The studies were included if they were placebo-controlled trials in design and reported SSRIs' effects on poststroke depression, anxiety, disability, dependence, motor abilities, and cognitive functions. Read More

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Development and diseases of the coronary microvasculature and its communication with the myocardium.

WIREs Mech Dis 2022 Jun 22:e1560. Epub 2022 Jun 22.

Institute of Anatomy, First Faculty of Medicine, Charles University, Prague, Czech Republic.

We review the current understanding of formation and development of the coronary microvasculature which supplies oxygen and nutrients to the heart myocardium and removes waste. We emphasize the close relationship, mutual development, and communication between microvasculature endothelial cells and surrounding cardiomyocytes. The first part of the review is focused on formation of microvasculature during embryonic development. Read More

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Myeloid cell-specific deletion of Capns1 prevents macrophage polarization toward the M1 phenotype and reduces interstitial lung disease in the bleomycin model of systemic sclerosis.

Arthritis Res Ther 2022 Jun 21;24(1):148. Epub 2022 Jun 21.

Department of Dermatology, Zhongshan Hospital, Fudan University, Xuhui District, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.

Background: Calpains are a family of calcium-dependent thiol proteases that participate in a wide variety of biological activities. In our recent study, calpain is increased in the sera of scleroderma or systemic sclerosis (SSc). However, the role of calpain in interstitial lung disease (ILD) has not been reported. Read More

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Vascular anomaly diagnosis by central venous catheter misplacement: a case report.

J Med Case Rep 2022 Jun 22;16(1):259. Epub 2022 Jun 22.

Department of Radiology, Ikazia Hospital Rotterdam, Rotterdam, The Netherlands.

Background: Congenital heart diseases rarely have a primary manifestation in adulthood. They are a rare cause of pulmonary hypertension in adults.

Case Presentation: A 70-year-old woman of Eurasian descent underwent emergency surgery for bowel ischemia. Read More

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Secretion of miRNA-326-3p by senescent adipose exacerbates myocardial metabolism in diabetic mice.

J Transl Med 2022 Jun 21;20(1):278. Epub 2022 Jun 21.

Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.

Background: Adipose tissue homeostasis is at the heart of many metabolic syndromes such as diabetes. Previously it has been demonstrated that adipose tissues from diabetic patients are senescent but whether this contributes to diabetic cardiomyopathy (DCM) remains to be elucidated.

Methods: The streptozotocin (STZ) type 1 diabetic mice were established as animal model, and adult mouse ventricular myocytes (AMVMs) isolated by langendorff perfusion as well as neonatal mouse ventricular myocytes (NMVMs) were used as cell models. Read More

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Cortical Anoxic Spreading Depolarization During Cardiac Arrest is Associated with Remote Effects on Peripheral Blood Pressure and Postresuscitation Neurological Outcome.

Neurocrit Care 2022 Jun 21. Epub 2022 Jun 21.

Department of Neurology, University of California, Irvine, Irvine, CA, USA.

Background: Spreading depolarizations (SDs) are self-propagating waves of neuronal and glial depolarizations often seen in neurological conditions in both humans and animal models. Because SD is thought to worsen neurological injury, the role of SD in a variety of cerebral insults has garnered significant investigation. Anoxic SD is a type of SD that occurs because of anoxia or asphyxia. Read More

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Progression of aortic stenosis after an acute myocardial infarction.

Open Heart 2022 Jun;9(1)

Québec Heart and Lung Institute, Laval University, Québec City, Québec, Canada

Background: Myocardial infarction (MI) has been shown to induce fibrotic remodelling of the mitral and tricuspid valves. It is unknown whether MI also induces pathological remodelling of the aortic valve and alters aortic stenosis (AS) progression. We thus compared AS progression after an acute MI and in patients with/without history of MI, and assessed post-MI pathobiological changes within the aortic valve leaflets in a sheep model. Read More

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