311,973 results match your criteria Heart Anatomy

"Inform the Head, Give Dexterity to the Hand, Familiarise the Heart": Seeing and Using Digitised Eighteenth-Century Specimens in a Modern Medical Curriculum.

Francis Osis

Adv Exp Med Biol 2021 ;1317:163-179

School of History, College of Arts, University of Glasgow, Glasgow, UK.

Recent years have seen an explosion of interest in digitising museum collections. Among the objects of interest are anatomical and pathological specimens found in medical museums. As researchers increasingly produce digital replicas of these preparations, ways of integrating these resources into the medical curriculum must be explored. Read More

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January 2021

Transcatheter mitral valve interventions: pre-procedural planning and intra-procedural guidance.

Minerva Cardiol Angiol 2021 May 4. Epub 2021 May 4.

Cardiovascular Imaging Unit, San Raffaele Hospital, Milan, Italy -

Mitral regurgitation is the most prevalent valve disease worldwide. Percutaneous mitral valve interventions are emerging as alternative options for high-risk patients with severe mitral regurgitation not eligible for conventional surgery. Accurate patient selection is based on a detailed pre-procedural multimodality imaging evaluation. Read More

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Expert Technique: Pediatric Tracheal Surgery.

World J Pediatr Congenit Heart Surg 2021 May;12(3):414-417

Department of Cardiothoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Substantial improvements in techniques of tracheal surgery for children have occurred in the past 20 years. Precise preoperative imaging with computed tomography clearly defines the anatomy for surgical planning and is assisted by on-the-table needle localization. The use of cardiopulmonary bypass greatly facilitates creation of an airtight, widely patent trachea. Read More

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Current Management of Anomalous Aortic Origin of a Coronary Artery: A Pan-Canadian Survey.

World J Pediatr Congenit Heart Surg 2021 May;12(3):387-393

Faculty of Medicine, 5620McGill University, Montreal, Canada.

Background: Anomalous aortic origin of a coronary artery (AAOCA) is a significant cause of sudden cardiac death (SCD) in children and adolescents. The natural history of AAOCA and the pathophysiology of AAOCA-related SCD are poorly understood. Therefore, the evaluation and management of AAOCA remain controversial. Read More

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Complex interventions in the failing heart.

Curr Opin Organ Transplant 2021 Jun;26(3):267-272

Division of Cardiovascular Diseases.

Purpose Of Review: Heart failure is a complex clinical syndrome with a substantial disease burden. We aim to review the interventional aspects of management of advanced heart failure, focusing on the role of management of coronary artery disease, valvular heart disease, and mechanical circulatory support.

Recent Findings: The patients with coronary artery disease and heart failure requiring revascularization are at higher risk than the rest of the general population. Read More

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Evaluation of right side foetal myocardial performance index in pregestational and gestational diabetes mellitus.

J Obstet Gynaecol 2021 May 2:1-6. Epub 2021 May 2.

Department of Obstetrics and Gynecology, Beykent University, Istanbul, Turkey.

The aim of our study is to investigate the myocardial performance index (MPI) of the right side of the foetal heart in pregestational and gestational diabetes mellitus and to compare it with non-diabetic pregnancies. This prospective cross-sectional study was conducted between August 2018 and March 2019 at Kanuni Sultan Suleyman Research and Training Hospital. Women with pregestational or gestational diabetes mellitus at 24-34 weeks of gestation were included in the study and non-diabetic pregnant women were included as the control group. Read More

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Effect of Presence of Ramus Intermedius Artery on Location of Culprit Lesions in Acute Left Circumflex Coronary Artery Occlusion.

J Saudi Heart Assoc 2021 19;33(1):35-40. Epub 2021 Apr 19.

Cardiology Department, Faculty of Medicine, Zagazig University, Egypt.

Background And Aim: Coronary artery anatomy frequently affects location of atherosclerotic plaques and subsequent culprit lesions. We sought to clarify whether presence or absence of Ramus Intermedius coronary artery (RI) would affect location of culprit lesions in acute left circumflex (LCX) coronary artery occlusion.

Methods: The study included 180 patients, 100 with a diagnosis of non-ST elevation myocardial infarction (NSTEMI) and 80 with ST elevation myocardial infarction (STEMI). Read More

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Regulation of capillary hemodynamics by K channels in resting skeletal muscle.

Physiol Rep 2021 Apr;9(8):e14803

Department of Kinesiology, Kansas State University, Manhattan, Kansas, USA.

ATP-sensitive K channels (K ) have been implicated in the regulation of resting vascular smooth muscle membrane potential and tone. However, whether K channels modulate skeletal muscle microvascular hemodynamics at the capillary level (the primary site for blood-myocyte O exchange) remains unknown. We tested the hypothesis that K channel inhibition would reduce the proportion of capillaries supporting continuous red blood cell (RBC) flow and impair RBC hemodynamics and distribution in perfused capillaries within resting skeletal muscle. Read More

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Heart rate variability in patients with low back pain: a systematic review.

Scand J Pain 2021 Apr 30. Epub 2021 Apr 30.

Postgraduate Program in Medicine (Cardiology), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.

Objectives: Heart rate variability (HRV) is an important physiological measure of the capacity for neurogenic homeostatic regulation, and an indirect measure of emotional processing. We aimed to investigate whether HRV parameters are altered in people with chronic low back pain when compared to healthy controls.

Methods: We searched on PubMed, Scopus, CINAHL, Web of Science, Cochrane Library, and PsycINFO from inception to January 2018. Read More

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Cardiovascular risk stratification by coronary computed tomography angiography imaging: current state-of-the-art.

Eur J Prev Cardiol 2021 Apr 30. Epub 2021 Apr 30.

1st Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens, 114 Vas. Sofias Avenue, 11527, Athens, Greece.

Current cardiovascular risk stratification by use of clinical risk score systems or plasma biomarkers is good but less than satisfactory in identifying patients at residual risk for coronary events. Recent clinical evidence puts now further emphasis on the role of coronary anatomy assessment by coronary computed tomography angiography (CCTA) for the management of patients with stable ischaemic heart disease. Available computed tomography (CT) technology allows the quantification of plaque burden, identification of high-risk plaques, or the functional assessment of coronary lesions for ischaemia detection and revascularization for refractory angina symptoms. Read More

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Pulmonary vein stenosis after HotBalloon pulmonary vein isolation of paroxysmal atrial fibrillation.

Heart Vessels 2021 Apr 30. Epub 2021 Apr 30.

The Heart Rhythm Center, Tokyo Heart Center, 5-4-12 Kitashinagawa, Shinagawa-ku, Tokyo, 141-0001, Japan.

HotBalloon-based pulmonary vein isolation (HBPVI) has yielded encouraging clinical results in the treatment of paroxysmal atrial fibrillation (PAF). However, pulmonary vein (PV) stenosis remains a concern. The influence of longer application duration on PV stenosis has not yet been systematically evaluated. Read More

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The Role of Cell Tracing and Fate Mapping Experiments in Cardiac Outflow Tract Development, New Opportunities through Emerging Technologies.

J Cardiovasc Dev Dis 2021 Apr 26;8(5). Epub 2021 Apr 26.

Department Anatomy & Embryology, Leiden University Medical Center, 2300RC Leiden, The Netherlands.

Whilst knowledge regarding the pathophysiology of congenital heart disease (CHDs) has advanced greatly in recent years, the underlying developmental processes affecting the cardiac outflow tract (OFT) such as bicuspid aortic valve, tetralogy of Fallot and transposition of the great arteries remain poorly understood. Common among CHDs affecting the OFT, is a large variation in disease phenotypes. Even though the different cell lineages contributing to OFT development have been studied for many decades, it remains challenging to relate cell lineage dynamics to the morphologic variation observed in OFT pathologies. Read More

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Myelodysplasia Syndrome, Clonal Hematopoiesis and Cardiovascular Disease.

Cancers (Basel) 2021 Apr 19;13(8). Epub 2021 Apr 19.

Division of Immunometabolism, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.

The development of myelodysplasia syndromes (MDS) is multiphasic and can be driven by a plethora of genetic mutations and/or abnormalities. MDS is characterized by a hematopoietic differentiation block, evidenced by increased immature hematopoietic cells, termed blast cells and decreased mature circulating leukocytes in at least one lineage (i.e. Read More

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The Impact of Acute Central Hypovolemia on Cerebral Hemodynamics: Does Sex Matter?

J Appl Physiol (1985) 2021 Apr 29. Epub 2021 Apr 29.

Department of Physiology & Anatomy, University of North Texas Health Science Center, United States.

Trauma-induced hemorrhage is a leading cause of disability and death due, in part, to impaired perfusion and oxygenation of the brain. It is unknown if cerebrovascular responses to blood loss are differentiated based on sex. We hypothesized that compared to males, females would have reduced tolerance to simulated hemorrhage induced by maximal lower body negative pressure (LBNP), and this would be associated with an earlier reduction in cerebral blood flow and cerebral oxygenation. Read More

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The Heart's Little Brain: Shedding New Light and CLARITY on the "Black Box".

Circ Res 2021 Apr 29;128(9):1297-1299. Epub 2021 Apr 29.

Department of Physiology, Anatomy and Genetics, Burdon Sanderson Cardiac Science Centre, University of Oxford, United Kingdom.

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Chronic Obstructive Pulmonary Disease and the Cardiovascular System: Vascular Repair and Regeneration as a Therapeutic Target.

Front Cardiovasc Med 2021 12;8:649512. Epub 2021 Apr 12.

Institute of Anatomy and Cell Biology, Julius-Maximilians-University Würzburg, Würzburg, Germany.

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide and encompasses chronic bronchitis and emphysema. It has been shown that vascular wall remodeling and pulmonary hypertension (PH) can occur not only in patients with COPD but also in smokers with normal lung function, suggesting a causal role for vascular alterations in the development of emphysema. Mechanistically, abnormalities in the vasculature, such as inflammation, endothelial dysfunction, imbalances in cellular apoptosis/proliferation, and increased oxidative/nitrosative stress promote development of PH, cor pulmonale, and most probably pulmonary emphysema. Read More

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The Cardioprotective Mechanism of Phenylaminoethyl Selenides (PAESe) Against Doxorubicin-Induced Cardiotoxicity Involves Frataxin.

Front Pharmacol 2020 12;11:574656. Epub 2021 Apr 12.

Department of Drug, Discovery and Development, Harrison School of Pharmacy, Auburn University, Alabama, AL, United States.

Doxorubicin (DOX) is an anthracycline cancer chemotherapeutic that exhibits cumulative dose-limiting cardiotoxicity and limits its clinical utility. DOX treatment results in the development of morbid cardiac hypertrophy that progresses to congestive heart failure and death. Recent evidence suggests that during the development of DOX mediated cardiac hypertrophy, mitochondrial energetics are severely compromised, thus priming the cardiomyocyte for failure. Read More

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COSMAS: a lightweight toolbox for cardiac optical mapping analysis.

Sci Rep 2021 Apr 28;11(1):9147. Epub 2021 Apr 28.

Department of Physiology, McGill University, Montréal, Canada.

Optical mapping is widely used in experimental cardiology, as it allows visualization of cardiac membrane potential and calcium transients. However, optical mapping measurements from a single heart or cell culture can produce several gigabytes of data, warranting automated computer analysis. Here we present COSMAS, a software toolkit for automated analysis of optical mapping recordings in cardiac preparations. Read More

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Anti-asthma Drugs Formoterol and Budesonide (Symbicort) Induce Orofacial Clefts, Gastroschisis and Heart Septum Defects in an Model.

In Vivo 2021 May-Jun;35(3):1451-1460

Institute of Histology and Embryology, Third Faculty of Medicine, Charles University, Prague, Czech Republic.

Background: We had a case in which three consecutive pregnancies resulted in birth of three children with an orofacial cleft. Their mother suffered from bronchial asthma and was treated using symbicort (corticosteroid budesonide plus bronchodilator formoterol) during her pregnancies. A hypothesis was assessed: these anti-asthmatics can induce an orofacial cleft in experimental model. Read More

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January 2021

Applied anatomy and surgical technique of the lateral single-position L5-S1 fusion.

Clin Anat 2021 Apr 28. Epub 2021 Apr 28.

The Spine Clinic of Oklahoma City, Oklahoma City, Oklahoma, USA.

The latest development in the anterior lumbar interbody fusion (ALIF) procedure is its application in the lateral position to allow for simultaneous posterior percutaneous screw placement. The technical details of the lateral ALIF technique have not yet been described. To describe the surgical anatomy relevant to the lateral ALIF approach we performed a comprehensive anatomical study. Read More

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Sexual Dysfunction before and after treatment of infrarenal aortic aneurysm patients.

Ann Vasc Surg 2021 Apr 24. Epub 2021 Apr 24.

Department of Heart- and Vascular Surgery, University Hospital of Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, 24105, Kiel, Germany.

Objective: Sexual dysfunction is supposed to be one major complication after treatment of infrarenal aortic aneurysms. It is still controversial how many patients suffer from a sexual dysfunction already before their operation and if there are any procedure-specific differences in postoperative sexual function depending on the operative procedure performed, e.g. Read More

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A simple, open and extensible gating control unit for cardiac and respiratory synchronisation control in small animal MRI and demonstration of its robust performance in steady-state maintained CINE-MRI.

Magn Reson Imaging 2021 Apr 24. Epub 2021 Apr 24.

Department of Oncology, University of Oxford, Old Road Campus Research Building, Off Roosevelt Drive, Oxford OX3 7DQ, United Kingdom. Electronic address:

Prospective cardiac gating during MRI is hampered by electromagnetic induction from the rapidly switched imaging gradients into the ECG detection circuit. This is particularly challenging in small animal MRI, as higher heart rates combined with a smaller myocardial mass render routine ECG detection challenging. We have developed an open-hardware system that enables continuously running MRI scans to be performed in conjunction with cardio-respiratory gating such that the relaxation-weighted steady state magnetisation is maintained throughout the scan. Read More

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Update On Shunt Closure In Neonates And Infants.

Expert Rev Cardiovasc Ther 2021 Apr 24. Epub 2021 Apr 24.

Sidra Heart Center, Sidra Medicine, Doha, Qatar.

Introduction: Cardiac defects that result in shunting are the most common types of congenital heart anomalies. Although these lesions can be simple, they can cause significant hemodynamic changes and can be challenging to manage in neonates and infants. Over the recent decades, the development of new transcatheter techniques and devices has made it safe and feasible to manage such defects when indicated, even in the smallest of patients. Read More

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Venous drainage of the heart of the red fox (Vulpes vulpes).

Folia Morphol (Warsz) 2021 Apr 26. Epub 2021 Apr 26.

Department of Internal Medicine, Faculty of Veterinary Medicine, University of Kafkas, Kars, Turkey.

Background: This study was carried out to reveal the coronary venous system of the Red fox (Vulpes vulpes) heart. The hearts used in the study were obtained from 6 Red foxes that were brought to the Kafkas University Wildlife Rescue and Rehabilitation Center after serious injuries due to firearms or traffic accidents and could not be saved despite all interventions.

Materials And Methods: Latex was injected from the cranial vena cava and caudal vena cava to expose the coronary vasculature. Read More

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Arterial hypertension and remodeling of the right ventricle.

Folia Morphol (Warsz) 2021 Apr 26. Epub 2021 Apr 26.

Department of Forensic Medicine, Medical University of Gdansk, Poland.

Background: In case of long-term and physiological loads (e.g. during pregnancy or regular athletics training), reversible morphological changes occur in the heart - cardiomyocytes undergo hypertrophy, however, this is not accompanied by impairment of left ventricular function or myocyte metabolism. Read More

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Bicuspid aortic valve annulus: assessment of geometry and size changes during the cardiac cycle as measured with a standardized method to define the annular plane.

Eur Radiol 2021 Apr 24. Epub 2021 Apr 24.

Department of Radiology, Erasmus Medical Center, P.O. Box 2040, 3000, CA, Rotterdam, The Netherlands.

Purpose: Bicuspid aortic valve (BAV) is a complex malformation affecting not merely the aortic valve. However, little is known regarding the dynamic physiology of the aortic annulus in these patients and whether it is similar to tricuspid aortic valves (TAV). Determining the BAV annular plane is more challenging than for TAV. Read More

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Mullins-Sheath Facilitated Delivery of Gore Cardioform ASD Occluder Devices for Closure of Large or Challenging Secundum Atrial Septal Defects.

J Invasive Cardiol 2021 Apr 23. Epub 2021 Apr 23.

CE Mullins Cardiac Catheterization Laboratories, The Lillie Frank Abercrombie Section of Cardiology, Texas Children's Hospital, Associate Professor of Pediatrics, Baylor College of Medicine, Attending Physician, Internal Medicine/Cardiology, Baylor St. Luke's Medical Center, 6651 Main Street, E 1920, Houston, TX 77030.

Objectives: To describe a deployment technique of the Gore Cardioform atrial septal defect (ASD) occluder (W.L. Gore and Associates) for large secundum ASDs and ASDs with challenging anatomy. Read More

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Gangliformis Intumescentia and Beyond: Antonio Scarpa and His Core Contribution to Neuroanatomy, Neurosurgery, and Otoneurosurgery.

World Neurosurg 2021 Apr 20. Epub 2021 Apr 20.

Neurosurgery Unit, Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy; Neurosurgery Unit, Department of Surgical Sciences, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy. Electronic address:

Nearly 250 years ago, Antonio Scarpa became a professor of anatomy and surgery only 2 years after he graduated from the University of Padua. The young lecturer soon became one of the most renowned anatomists in Italy and a director of the Faculty of Medicine at the University of Pavia. He worked in the fields of general surgery and ophthalmology. Read More

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Inter-observer and Inter-vendor Variability in Strain Measurements in Patients with Single Right Ventricular Anatomy.

Pediatr Cardiol 2021 Apr 23. Epub 2021 Apr 23.

Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Myocardial strain offers new insights into ventricular performance, There are software packages from several different companies used to ascertain this, and little data is available in patients with single right ventricle (sRV) physiology. We aimed to compare the analysis of two strain software applications using a cohort of patients with sRV for both inter-vendor and inter-observer variability. Echocardiograms from 85 patients with sRV (122 separate studies) were prospectively evaluated. Read More

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