1,409,044 results match your criteria Heart Advisor [Journal]


Possible involvement of Fas/FasL-dependent apoptotic pathway in α-bisabolol induced cardiotoxicity in zebrafish embryos.

Chemosphere 2018 Dec 8;219:557-566. Epub 2018 Dec 8.

Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 28789 East Jingshi Road, Jinan, 250103, Shandong Province, PR China; Key Laboratory for Drug Screening Technology of Shandong Academy of Sciences, 28789 East Jingshi Road, Jinan, 250103, Shandong Province, PR China. Electronic address:

α-Bisabolol, an unsaturated monocyclic sesquiterpene alcohol, is a common ingredient in many pharmaceuticals and personal care products (PPCPs). Despite being widely used, little is known about its toxic effects on organisms and aquatic environment. In this study, we investigated the developmental toxicity of α-Bisabolol, especially its effects on the cardiac development using zebrafish embryos as a model. Read More

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December 2018

Gut microbiota-dependent trimethylamine-N-oxide (TMAO) shows a U-shaped association with mortality but not with recurrent venous thromboembolism.

Thromb Res 2018 Dec 6;174:40-47. Epub 2018 Dec 6.

Center for Molecular Cardiology, Laboratory for Platelet Research, University of Zurich, Schlieren, Switzerland; Department of Internal Medicine, Cantonal Hospital of Baden, Baden, Switzerland. Electronic address:

Introduction: Gut microbiota-dependent trimethylamine-N-oxide (TMAO) correlates with arterial thrombotic events including myocardial infarction and stroke, and mortality. However, the association of TMAO with recurrent venous thromboembolism (VTE) and mortality remains unknown.

Methods: TMAO plasma levels were assessed by high performance liquid chromatography in 859 patients aged ≥65 years with acute VTE and categorized into low (<2. Read More

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December 2018
1 Read

Intentional early delivery versus expectant management for preterm premature rupture of membranes at 28-32 weeks' gestation: A multicentre randomized controlled trial (MICADO STUDY).

Eur J Obstet Gynecol Reprod Biol 2018 Dec 5;233:30-37. Epub 2018 Dec 5.

Department of Obstetrics and Gynecology, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Lyon, France.

Objectives: Preterm premature rupture of fetal membranes (PPROM) exposes the fetus to preterm birth, and optimal timing for delivery is controversial. The aim of this study was to compare intentional early delivery ("active management") with expectant management in very preterm birth (28-32 weeks).

Study Design: We conducted a prospective randomized controlled trial with intent-to-treat analysis, at 19 tertiary-care hospitals in France and 1 in Geneva, Switzerland. Read More

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December 2018

Anti-depressive effect of Shuangxinfang on rats with acute myocardial infarction: Promoting bone marrow mesenchymal stem cells mobilization and alleviating inflammatory response.

Biomed Pharmacother 2018 Dec 12;111:19-30. Epub 2018 Dec 12.

The Third Affiliate Hospital of Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address:

Bone marrow mesenchymal stem cells (BM-MSCs) are recruited to injured site for cardiac self-repairing in acute myocardial infarction (AMI), but the spontaneous mobilization of BM-MSCs is insufficient for self-repairing. Inflammation initiated by necrosis cardiomyocytes induced cardiac remodeling and depression. Given the anti-inflammatory effects of BM-MSCs and the inextricably relationship among inflammation, ventricular remodeling and depression following AMI, methods focused on enhancing BM-MSCs mobilization are promising. Read More

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December 2018

Home monitoring with IT-supported specialist management versus home monitoring alone in patients with heart failure: Design and baseline results of the SUPPORT-HF 2 randomized trial.

Authors:

Am Heart J 2018 Sep 25;208:55-64. Epub 2018 Sep 25.

The George Institute for Global Health, University of Oxford, 1st Floor, Hayes House, 75 George St, Oxford, United Kingdom.

Objectives: SUPPORT-HF 2 tests the hypothesis that home monitoring with information technology-supported specialist management is more effective in optimizing medical therapy than is home monitoring alone for patients with heart failure.

Methods And Results: The study was designed as a 2-armed partially blinded parallel randomized controlled trial. Seven sites in the United Kingdom (UK) recruited a total of 202 adults with heart failure at high risk of adverse outcomes and with potential to benefit from remote management (mean age 73 years, 28% female, median left ventricular ejection fraction 37%). Read More

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September 2018
1 Read

The unit of Estimated Plasma Volume in Patients with Heart Failure using the Strauss-derived Duarte formula is not liter but dL/g.

J Card Fail 2018 Dec 12. Epub 2018 Dec 12.

Université de Lorraine, INSERM, Centre d'Investigations Cliniques 1433, CHRU de Nancy, Inserm 1116 and INI-CRCT (Cardiovascular and Renal Clinical Trialists) F-CRIN Network, Nancy, France; Département de Cardiologie, CHRU de Nancy, Nancy, France. Electronic address:

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December 2018

Palliative Care Consultation Before Left Ventricular Assist Device Implantation.

J Pain Symptom Manage 2018 Dec 12. Epub 2018 Dec 12.

Adult Palliative Care Service, Department of Medicine, Columbia University Medical Center, New York, NY, USA.

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December 2018

Molecular mechanism involved in cyclophosphamide-induced cardiotoxicity: Old drug with a new vision.

Life Sci 2018 Dec 12. Epub 2018 Dec 12.

Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India. Electronic address:

Cyclophosphamide (CP) is an important anticancer drug which belongs to the class of alkylating agent. Cyclophosphamide is mostly used in bone marrow transplantation, rheumatoid arthritis, lupus erythematosus, multiple sclerosis, neuroblastoma and other types of cancer. Dose-related cardiotoxicity is a limiting factor for its use. Read More

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December 2018
1 Read

Effects of sex and menstrual cycle phase on cardiac response and alpha- amylase levels in psychosocial stress.

Biol Psychol 2018 Dec 12. Epub 2018 Dec 12.

Laboratory of Social Cognitive Neuroscience, IDOCAL, Department of Psychobiology, University of Valencia, 46010 Valencia, Spain.

The impact of sex and the menstrual cycle phase on the autonomic response to psychosocial stress remains controversial. This study explored autonomic nervous system activity through salivary alpha-amylase, heart rate, and heart rate variability responses to the Trier Social Stress Test (TSST) in healthy young people. The sample was composed of 25 men, 26 women in the luteal phase, and 25 women in the follicular phase, from 18 to 25 years of age. Read More

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December 2018

Epidemiology and Effects of Bacterial Infections in Patients With Cirrhosis Worldwide.

Gastroenterology 2018 Dec 12. Epub 2018 Dec 12.

Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine - DIMED, University of Padova, Padova, Italy. Electronic address:

Background And Aims: Bacterial infections are common and life-threatening in patients with cirrhosis. Little is known about the epidemiology of bacterial infections in different regions. We performed a multicenter prospective intercontinental study to assess the prevalence and outcomes of bacterial and fungal infections in patients with cirrhosis. Read More

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December 2018
16.716 Impact Factor

Technical Aspects of the Use of the Radial Artery in Coronary Artery Bypass Surgery.

Ann Thorac Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, United States.

Background: The radial artery (RA) has been used for coronary artery bypass surgery for more than 25 years. The recent confirmation of the clinical benefits associated with the use of the artery is likely to drive a new interest toward this conduit in the next few years METHODS: A group of surgeons with extensive experience in the systematic use of the RA summarize here the key technical aspects of the use of the conduit for coronary bypass operations.

Results: Preoperative evaluation of the ulnar collateral circulation and attention to the characteristics of the target vessel are key for the successful use of the radial artery. Read More

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December 2018

Cardio-omentopexy Reduces Cardiac Fibrosis and Heart Failure after Experimental Pressure Overload.

Ann Thorac Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Cardiovascular-Thoracic Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL. Electronic address:

Background: The pedicled greater omentum has been shown to offer benefit in ischemic heart disease for both animal models and human patients. The impact of cardio-omentopexy in a pressure overload model of left ventricular hypertrophy (LVH) is unknown.

Methods: LVH was created in rats by banding the ascending aorta after right thoracotomy (n=23). Read More

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December 2018

First report of two consecutive respiratory syncytial virus outbreaks by the novel genotypes ON-1 and NA-2 in a neonatal intensive care unit.

J Pediatr (Rio J) 2018 Dec 12. Epub 2018 Dec 12.

Santa Casa de São Paulo, Unidade de Doenças Infecciosas Pediátricas, São Paulo, SP, Brazil.

Objective: Respiratory syncytial virus is a pathogen frequently involved in nosocomial outbreaks. Although several studies have reported nosocomial outbreaks in neonatal intensive care units, molecular epidemiology data are scarce. Here, the authors describe two consecutive respiratory syncytial virus outbreaks caused by genotypes ON-1 and NA-2 in a neonatal intensive care unit in São Paulo, Brazil. Read More

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December 2018

To explore of the prevalence and outcomes of advance care planning for patients with left ventricular assist devices: a review.

J Clin Nurs 2018 Dec 15. Epub 2018 Dec 15.

DMedEth RN SFHEA Senior Lecturer University of Birmingham.

Aims And Objectives: To explore of the prevalence and outcomes of advance care planning for patients with left ventricular assist devices: a review.

Background: End-stage heart failure is associated with significant symptom burden at rest. Left ventricular assist devices are not curative nevertheless they alleviate symptoms and prolong survival. Read More

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December 2018

Vagus nerve stimulation reduces ventricular arrhythmias and increases ventricular electrical stability.

Pacing Clin Electrophysiol 2018 Dec 15. Epub 2018 Dec 15.

Xinjiang Key Laboratory of Medical Animal Model Research, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Background: Transcutaneous stimulation of the auricular branch of the vagus nerve (AB-VNS) is a potentially non-invasive, inexpensive and safe approach for vagus nerve stimulation that suppresses the induction and duration of atrial fibrillation and reduces sympathetic nerve outflow in healthyhumans. Researchers have not determined whether AB-VNS affects ventricular arrhythmias.

Objective: To evaluate the antiarrhythmic effects of noninvasive AB-VNS on ventricular arrhythmias induced by myocardial infarction (MI). Read More

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December 2018

Blood pressure reactivity at onset of mental stress determines sympathetic vascular response in young adults.

Physiol Rep 2018 Dec;6(24):e13944

School of Medicine, Western Sydney University, Sydney, New South Wales, Australia.

We have previously shown in young males that the rate of rise in blood pressure (BP) at the onset of mental stress determines whether or not muscle sympathetic nerve activity (MSNA) has a role in driving the pressor response. The aim of this study was to investigate these interactions in young females. BP and MSNA were recorded continuously in 19 females and 21 males during 2-min mental stressors (mental arithmetic and Stroop test). Read More

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December 2018

A novel mapping technique to identify focal nonsustained atrial tachycardia: A case report of self-reference mapping technique.

J Cardiovasc Electrophysiol 2018 Dec 14. Epub 2018 Dec 14.

Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital.

Catheter ablation is an effective therapeutic strategy for atrial tachycardia (AT). However, it is clinically difficult to map a difficult-to-induce or nonsustained AT for distinguishing between AT and sinus foci. We presented a case with nonsustained focal atrial tachycardia(FAT) (Fig. Read More

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December 2018
2 Reads

Transforming the experience of aortic valve disease in older patients: a qualitative study.

J Clin Nurs 2018 Dec 14. Epub 2018 Dec 14.

Department of Cardiothoracic Surgery, the Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Aim And Objectives: To explore patients' lived experiences of daily life and coping with recovery after Transcatheter aortic valve implantation (TAVI).

Background: TAVI is increasingly used to treat older patients with severe aortic stenosis with high surgical risk. This novel treatment has been shown to be effective in relieving symptoms, improving survival and prognosis, but its impact on patients' daily life has been sparsely explored. Read More

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December 2018

Laparoscopic repositioning of a dislocated pacemaker into the rectovesical pouch.

Pacing Clin Electrophysiol 2018 Dec 15. Epub 2018 Dec 15.

Department of Cardiology, Heart Center Brandenburg, Bernau, Berlin, Germany.

Dislocation of the epicardial pacemaker into the peritoneal cavity is an uncommon but potentially life-threatening complication.We report a case of a 74-year-old with an abdominally implanted epicardial pacemaker that migrated through the peritoneum to the excavatio rectovesicalis. The laparoscopic approach was chosen because of the increased risks of perioperative morbidity and decreased survival. Read More

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December 2018

Catecholamine Response to Exercise in Patients with Non-Obstructive Hypertrophic Cardiomyopathy.

J Physiol 2018 Dec 15. Epub 2018 Dec 15.

Division of Cardiology, Massachusetts General Hospital, 55 Fruit Street, Yawkey Suite 5B, Boston, MA, USA.

Key Points Summary: Intense physical activity, a potent stimulus for sympathetic nervous system activation, is thought to increase the risk of malignant ventricular arrhythmias among patients with hypertrophic cardiomyopathy (HCM). As a result, the majority of patients with HCM deliberately reduce their habitual physical activity after diagnosis and this lifestyle change puts them at risk for sequelae of a sedentary lifestyle; weight gain, hypertension, hyperlipidemia, insulin resistance, coronary artery disease and increased morbidity and mortality. We show that plasma catecholamine levels remain stably low at exercise intensities below the ventilatory threshold, a parameter that can be defined during cardiopulmonary exercise testing, but rise rapidly at higher intensities of exercise. Read More

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December 2018
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Periventricular Microglial Cells Interact with Dividing Precursor Cells in the Nonhuman Primate and Rodent Prenatal Cerebral Cortex.

J Comp Neurol 2018 Dec 15. Epub 2018 Dec 15.

Department of Pediatrics, School of Medicine, UC Davis, Davis, CA.

Cortical proliferative zones have been studied for over 100 years, yet recent data has revealed that microglial cells constitute a sizeable proportion of ventricular zone cells during late stages of cortical neurogenesis. Microglia begin colonizing the forebrain after neural tube closure and during later stages of neurogenesis populate regions of the developing cortex that include the proliferative zones. We previously showed that microglia regulate the production of cortical cells by phagocytosing neural precursor cells (NPCs), but how microglia interact with NPCs remains poorly understood. Read More

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December 2018

Feasibility of transcatheter prosthetic paravalvular leakage closure: a single-center, exploratory safety evaluation study of transcatheter closure of prosthetic paravalvular regurgitation in Japan (STOP PARA study).

Gen Thorac Cardiovasc Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Suita, Japan.

Objective: The standard treatment of prosthetic paravalvular leakage (PVL) accompanied by heart failure or hemolytic anemia is repeat open surgery. Although favorable outcomes for transcatheter prosthetic PVL closure in patients with a high surgical risk for repeat open surgery have been reported, procedural feasibility has not been examined in Japan.

Methods: From March 2015 to November 2015, transcatheter PVL closure in mitral position was performed in four patients (age range 41-78, three females) with high surgical risk due to history of repeated surgeries, chest radiation and reconstruction of the mitral annulus after debridement of abscess owing to infective endocarditis. Read More

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December 2018
2 Reads

Pulmonary Hypertension During Pregnancy in New York State, 2003-2014.

Matern Child Health J 2018 Dec 14. Epub 2018 Dec 14.

Department of Anesthesiology, Columbia University College of Physicians and Surgeons, 622 West 168th Street, PH5-505, New York, NY, 10032, USA.

Objectives This study examined the prevalence and temporal trends in (a) pulmonary hypertension (PH) during pregnancy and (b) mortality and morbidity during pregnancy with and without PH. Methods This was a retrospective observational study of the 2003-2014 New York State Inpatient Database. PH was categorized as primary or secondary and pregnancy as loss or termination of pregnancy, preterm birth, or term birth. Read More

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December 2018

Treatment strategies and outcomes in patients with non-ST-elevation acute coronary syndrome in the Netherlands.

Authors:
P Damman J J Piek

Neth Heart J 2018 Dec 14. Epub 2018 Dec 14.

Department of Cardiology, Academic Medical Centre, Location Meibergdreef, University of Amsterdam, Amsterdam, The Netherlands.

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December 2018

An irregular narrow complex tachycardia: atrial fibrillation or something else?

Neth Heart J 2018 Dec 14. Epub 2018 Dec 14.

Department of Cardiology, Amsterdam UMC, Amsterdam Cardiovascular Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

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December 2018

An irregular narrow complex tachycardia: atrial fibrillation or something else?

Neth Heart J 2018 Dec 14. Epub 2018 Dec 14.

Department of Cardiology, Amsterdam UMC, Amsterdam Cardiovascular Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

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December 2018

The influence of age on the psychological profile of patients with cardiac implantable electronic devices: results from the Italian population in a multicenter study conducted by the European Heart Rhythm Association.

Aging Clin Exp Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Electrophysiology, Heart Center of Leipzig, Leipzig, Germany.

Background: Cardiac implantable electronic devices (CIEDs) are widely used to treat bradyarrhythmias or improve the prognosis of patients with heart failure (HF).

Aims: To evaluate age-related (≤ 75 vs. > 75 years) attitudes, worries, psychological effects and needs in an Italian CIEDs population. Read More

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December 2018

Characteristics and outcomes of patients ≤ 75 years who underwent transcatheter aortic valve implantation: insights from the SOURCE 3 Registry.

Clin Res Cardiol 2018 Dec 14. Epub 2018 Dec 14.

Division of Adult Congenital and Valvular Heart Disease, Department of Cardiovascular Medicine, University Hospital Muenster, Muenster, Germany.

Background: Current trials and registries of transcatheter valve implantation (TAVI) mostly include patients older than 75 years. Little is known about younger patients who undergo this treatment. We investigated comorbidities among patients < 75 years old who underwent TAVI in the SAPIEN 3™ European post-approval SOURCE 3 Registry, and analysed outcomes at 30 days and 1 year. Read More

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December 2018

[Image-based screening].

Authors:
G Layer

Radiologe 2018 Dec 14. Epub 2018 Dec 14.

Zentralinstitut für Diagnostische und Interventionelle Radiologie, Klinikum Ludwigshafen gGmbH, Bremserstraße 79, 67063, Ludwigshafen, Deutschland.

Screening is a special issue in medical questions concerning disease prevention. Preconditions for screening are clearly defined by the World Health Organization. High prevalence, effectiveness of therapy, availability of accepted test procedure and consensus concerning the economic concerns are necessary for successful implementation of a screening program. Read More

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December 2018

Holt-Oram syndrome: clinical and molecular description of 78 patients with TBX5 variants.

Eur J Hum Genet 2018 Dec 14. Epub 2018 Dec 14.

CHU Lille, Clinique de Génétique, 59000, Lille, France.

Holt-Oram syndrome (HOS) is an autosomal dominant condition characterised by the association of congenital heart defect (CHD), with or without rhythm disturbances and radial defects, due to TBX5 variants. The diagnosis is challenged by the variability of expression and the large phenotypic overlap with other conditions, like Okihiro syndrome, TAR syndrome or Fanconi disease. We retrospectively reviewed 212 patients referred for suspicion of HOS between 2002 and 2014, who underwent TBX5 screening. Read More

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December 2018

Inappropriate left ventricular mass after preeclampsia: another piece of the puzzle Inappropriate LVM and PE.

Hypertens Res 2018 Dec 14. Epub 2018 Dec 14.

Maternal Fetal Medicine Unit, Department of Obstetrics and Gynecology, University of Brescia, Brescia, Italy.

Excessive left ventricular (LV) mass (LVM) increase results in inefficient LV work with high energy waste and a negative prognostic effect. We aimed to investigate the presence of inappropriate LVM and to calculate the myocardial mechanoenergetic efficiency index (MEEi) in asymptomatic women with a history of early-onset (EO) or late-onset (LO) pre-eclampsia (PE). Among all women diagnosed with PE in the years 2009-2013, after applying inclusion/exclusion criteria and cost-effectiveness analysis, we randomly selected thirty women who experienced EO-PE, thirty with a previous LO-PE and thirty healthy controls to undergo echocardiography from 6 months to 4 years after delivery. Read More

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December 2018

Refining AML outcome prediction.

Leukemia 2018 Dec 14. Epub 2018 Dec 14.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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December 2018

Author Correction: Comparison of 1D and 3D Models for the Estimation of Fractional Flow Reserve.

Sci Rep 2018 Dec 14;8(1):17962. Epub 2018 Dec 14.

National Laboratory for Scientific Computing, LNCC/MCTIC, Av. Getúlio Vargas, 333, Petrópolis-RJ, 25651-075, Brazil.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. Read More

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December 2018

Transcriptome 3'end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma.

Nat Commun 2018 Dec 14;9(1):5331. Epub 2018 Dec 14.

Posttranscriptional Gene Regulation, Cancer Research and Experimental Haemostasis, University Medical Centre Mainz, Mainz, 55131, Germany.

Diversification at the transcriptome 3'end is an important and evolutionarily conserved layer of gene regulation associated with differentiation and dedifferentiation processes. Here, we identify extensive transcriptome 3'end-alterations in neuroblastoma, a tumour entity with a paucity of recurrent somatic mutations and an unusually high frequency of spontaneous regression. Utilising extensive RNAi-screening we reveal the landscape and drivers of transcriptome 3'end-diversification, discovering PCF11 as critical regulator, directing alternative polyadenylation (APA) of hundreds of transcripts including a differentiation RNA-operon. Read More

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December 2018

Right Heart Failure syndrome and the art of medicine.

Aging (Albany NY) 2018 Dec 13. Epub 2018 Dec 13.

Department of Cardiology, University Hospital of Antwerp, Antwerp, Belgium.

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December 2018

Serum rantes, transforming growth factor-β1 and interleukin-6 levels correlate with cardiac muscle fibrosis in patients with aortic valve stenosis.

J Physiol Pharmacol 2018 Aug 9;69(4). Epub 2018 Dec 9.

Department of Interventional Cardiology, Jagiellonian University College of Medicine and the John Paul II Hospital, Cracow, Poland.

Regulated on Activation Normal T Expressed and Secreted (RANTES) chemokine is involved in the initiation of inflammation and immune-cell recruitment. Interleukin -6 (IL-6) is used as a general index of severity of the chronic inflammatory process. Finally, transforming growth factor-β (TGF-β) is an immune biomarker potentially involved in the regulation of valve fibrosis and calcification. Read More

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Interleukin-6 deficiency modifies the effect of high fat diet on myocardial expression of fatty acid transporters and myocardial lipids.

J Physiol Pharmacol 2018 Aug 9;69(4). Epub 2018 Dec 9.

Department of Physiology, Medical University of Bialystok, Bialystok, Poland.

Chronic inflammation is a critical feature of obesity in the development of myocardial dysfunction. The observations that interleukin-6 (IL-6) is implicated in lipid and glucose homeostasis as well as its connection with the pathogenesis of insulin resistance might suggest the involvement of this cytokine in metabolic disorders of the failing heart. In the present study we aimed to assess the effects of IL-6 ablation in mice fed with normal and high fat diet on the myocardial expression of glucose and fatty acid transporting proteins, and to evaluate the paralleled alterations in lipid content. Read More

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Variable gender-dependent platelet responses to combined antiplatelet therapy in patients with stable coronary-artery disease.

J Physiol Pharmacol 2018 Aug 9;69(4). Epub 2018 Dec 9.

Department of Laboratory Diagnostics, Pomeranian Medical University, Szczecin, Poland.

Antiplatelet therapy is considered as a standard procedure against atherosclerotic cardiovscular disease but this therapy has limited effect if resistance to acetylsalicylic acid or clopidogrel is present. Important factors associated with resistance are gender; or inflammation possibly associated with membrane microparticles (MP). It was decided to challenge the hypothesis that differential responses to dual antiplatelet therapy are conditioned by gender and/or proinflammatory status. Read More

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Survival and new-onset morbidity after critical care admission for acute pancreatitis in Scotland: a national electronic healthcare record linkage cohort study.

BMJ Open 2018 Dec 14;8(12):e023853. Epub 2018 Dec 14.

Surgery, School of Medicine, University of Edinburgh, Edinburgh, UK.

Introduction: Severe acute pancreatitis (AP) requiring critical care admission (ccAP) impacts negatively on long-term survival.

Objective: To document organ-specific new morbidity and identify risk factors associated with premature mortality after an episode of ccAP.

Design: Cohort study. Read More

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December 2018

Clinical and genetic associations of renal function and diabetic kidney disease in the United Arab Emirates: a cross-sectional study.

BMJ Open 2018 Dec 14;8(12):e020759. Epub 2018 Dec 14.

Center of Biotechnology, Khalifa University, Abu Dhabi, United Arab Emirates.

Objectives: Within the Emirati population, risk factors and genetic predisposition to diabetic kidney disease (DKD) have not yet been investigated. The aim of this research was to determine potential clinical, laboratory and reported genetic loci as risk factors for DKD.

Research Design And Methods: Four hundred and ninety unrelated Emirati nationals with type 2 diabetes mellitus (T2DM) were recruited with and without DKD, and clinical and laboratory data were obtained. Read More

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December 2018

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.

Lancet Respir Med 2018 Dec 11. Epub 2018 Dec 11.

Division of Respiratory Medicine, National Institute for Health Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK. Electronic address:

Background: Few genetic studies that focus on moderate-to-severe asthma exist. We aimed to identity novel genetic variants associated with moderate-to-severe asthma, see whether previously identified genetic variants for all types of asthma contribute to moderate-to-severe asthma, and provide novel mechanistic insights using expression analyses in patients with asthma.

Methods: In this genome-wide association study, we used a two-stage case-control design. Read More

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December 2018

HDAC inhibitor valproic acid protects heart function through Foxm1 pathway after acute myocardial infarction.

EBioMedicine 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiac Surgery, Cardiovascular Center, The University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

Background: Epigenetic histone acetylation is a major event controlling cell functions, such as metabolism, differentiation and repair. Here, we aim to determine whether Valproic acid (VPA), a FDA approved inhibitor of histone deacetylation for bipolar disease, could protect heart against myocardial infarction (MI) injury and elucidate key molecular pathways.

Methods: VPA was administrated to MI rats at different time points, onset and after MI injury. Read More

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December 2018

Early onset children's interstitial lung diseases: Discrete entities or manifestations of pulmonary dysmaturity?

Paediatr Respir Rev 2018 Oct 9. Epub 2018 Oct 9.

Department of Histopathology, Royal Brompton & Harefield NHS Foundation Trust and National Heart and Lung Institute, Imperial College, London, UK.

Interstitial lung diseases in children (chILD) are rare and diverse. The current classifications include a group of early onset chILD specific to infancy, namely neuro-endocrine cell hyperplasia of infancy (NEHI), pulmonary interstitial glycogenosis (PIG) and the alveolar capillary-congenital acinar dysplasia (ACD-CAD) spectrum, as well as alveolar growth disorders. NEHI and PIG cells are seen in the normal developing foetal lung. Read More

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October 2018

Towards a tailored cryo-pulmonary vein isolation. Lessons learned from second-generation cryoballoon ablation.

Trends Cardiovasc Med 2018 Nov 16. Epub 2018 Nov 16.

Heart Rhythm Management Centre, UZ Brussel-VUB, Brussels, Belgium.

Second-generation cryoballoon ablation has emerged as an effective and practical approach for the treatment of atrial fibrillation. It gained the overall interest of the electrophysiology community due to its excellent success rates, and reproducible clinical outcomes comparable to the point-by-point radiofrequency technique. This technology offers several advantages including a fast learning curve and shorter procedure times making this device widely adopted in many EP-laboratories as an alternative strategy to conventional point-by-point radiofrequency ablation. Read More

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November 2018

Left ventricular hypertrophy is a possible biomarker for early mortality after type B aortic dissection.

J Vasc Surg 2018 Dec 11. Epub 2018 Dec 11.

Division of Vascular Surgery, Department of Surgery, University of Washington, Seattle, Wash. Electronic address:

Objective: Data regarding the cardiac abnormalities associated with Stanford type B aortic dissection (TBAD) and whether these abnormalities are related to outcomes are limited. We describe the prevalence of cardiac abnormalities in patients with TBAD as detected by echocardiography.

Methods: This retrospective review included patients with TBAD presenting between 1990 and 2016. Read More

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December 2018

Left Ventricular Global Longitudinal Strain Can Reliably Be Measured from a Single Apical Four-Chamber View in Patients with Heart Failure.

J Am Soc Echocardiogr 2018 Dec 11. Epub 2018 Dec 11.

Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University, New Haven, Connecticut.

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December 2018

A multicomponent method assessing healthy cardiovascular urban environments: The Heart Healthy Hoods Index.

Health Place 2018 Dec 11. Epub 2018 Dec 11.

Social and Cardiovascular Epidemiology Research Group, School of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. Electronic address:

Previous studies have examined the built environment mostly focusing on a single exposure construct (e.g. walkability) to examine its association with health outcomes. Read More

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December 2018

Keeping the Heart Fitm2 during Chemotherapy.

Mol Ther 2018 Dec 11. Epub 2018 Dec 11.

Hubrecht Institute, KNAW and University Medical Center Utrecht, the Netherlands; Department of Cardiology, University Medical Center Utrecht, the Netherlands. Electronic address:

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December 2018

Commentary Regarding "Outcomes After One Stage Versus Two Stage Open Repair of Type II Thoraco-abdominal Aortic Aneurysms".

Eur J Vasc Endovasc Surg 2018 Dec 11. Epub 2018 Dec 11.

German Aortic Centre Hamburg, Department of Vascular Medicine, University Heart Centre, Hamburg, Germany. Electronic address:

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December 2018
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