1,421,000 results match your criteria Heart & Lung: The Journal of Acute and Critical Care[Journal]


Predicting the Quality of Warfarin Therapy: Reframing the Question.

Thromb Haemost 2019 Feb 22. Epub 2019 Feb 22.

Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, Michigan, United States.

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http://dx.doi.org/10.1055/s-0039-1681060DOI Listing
February 2019

Varied effects of dietary carotenoid supplementation on oxidative damage in tissues of two waterfowl species.

Comp Biochem Physiol B Biochem Mol Biol 2019 Feb 19. Epub 2019 Feb 19.

College of Health Solutions, Arizona State University, Phoenix, AZ, United States of America; School of Life Sciences, Arizona State University, Tempe, AZ, United States of America. Electronic address:

Carotenoids are regarded as a cornerstone of avian vitality and coloration. Currently, the antioxidant potential of dietary carotenoids is debated for birds. Although some studies support a protective role, others report either no effect or pro-oxidant effects. Read More

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http://dx.doi.org/10.1016/j.cbpb.2019.02.003DOI Listing
February 2019

Estimation of the hydrogen peroxide producing capacities of liver and cardiac mitochondria isolated from C57BL/6N and C57BL/6J mice.

Free Radic Biol Med 2019 Feb 19. Epub 2019 Feb 19.

Department of Biochemistry, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada. Electronic address:

Here, we examined the hydrogen peroxide (HO) producing capacities of pyruvate dehydrogenase (PDH), α-ketoglutarate dehydrogenase (KGDH), proline dehydrogenase (PRODH), glycerol-3-phosphate dehydrogenase (G3PDH), succinate dehydrogenase (SDH; complex II), and branched-chain keto acid dehydrogenase (BCKDH), in cardiac and liver mitochondria isolated from C57BL/6N (6N) and C57BL/6J (6J) mice. Various inhibitor combinations were used to suppress ROS production by complexes I, II, and III and estimate the native rates of HO production for these enzymes. Overall, liver mitochondria from 6N mice produced ∼2-fold more ROS than samples enriched from 6J mice. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.02.012DOI Listing
February 2019

Accuracy and usability of single-lead ECG from smartphones - A clinical study.

Indian Pacing Electrophysiol J 2019 Feb 19. Epub 2019 Feb 19.

Department of Heart Disease, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway.

Background: Several wireless ECG devices are commercially available for possible screening, monitoring and diagnosis of rhythms. The field is rapidly expanding, and some devices have demonstrated acceptable qualities. The objective was to evaluate the accuracy, usability and diagnostic capabilities of smartphone ECG (spECG) in both patients and healthy controls. Read More

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http://dx.doi.org/10.1016/j.ipej.2019.02.006DOI Listing
February 2019

Knockout of Wdr1 results in cardiac hypertrophy and impaired cardiac function in adult mouse heart.

Gene 2019 Feb 19. Epub 2019 Feb 19.

Biomedical Research Institute, College of Life Science and Health, Wuhan University of Science and Technology, Wuhan, Hubei Province 430081, PR China. Electronic address:

WDR1 is a major cofactor of the actin depolymerizing factor (ADF)/cofilin, accelerating ADF/cofilin-mediated actin disassembly. We had previously showed that WDR1-mediated actin dynamics is required for postnatal myocardial growth and adult myocardial maintenance in mice, in which the detailed phenotypes of adult cardiomyocyte-specific Wdr1 deletion mice had not been analyzed. In this study, we systematically analyzed the role of Wdr1 in adult mouse heart. Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.023DOI Listing
February 2019

Anchoring in a storm: the importance of substrate in polymorphic ventricular arrhythmias.

Heart Rhythm 2019 Feb 19. Epub 2019 Feb 19.

Cardiac Electrophysiology Program, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2019.02.022DOI Listing
February 2019

Biomaterializing the promise of cardiac tissue engineering.

Biotechnol Adv 2019 Feb 19. Epub 2019 Feb 19.

Division of Cardiology, Department of Medicine, Duke University Health System, Durham, NC, USA; Department of Biomedical Engineering, Duke University, Durham, NC, USA. Electronic address:

During an average individual's lifespan, the human heart pumps nearly 200 million liters of blood delivered by approximately 3 billion heartbeats. Therefore, it is not surprising that native myocardium under this incredible demand is extraordinarily complex, both structurally and functionally. As a result, successful engineering of adult-mimetic functional cardiac tissues is likely to require utilization of highly specialized biomaterials representative of the native extracellular microenvironment. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.02.009DOI Listing
February 2019

Long non-coding RNA cytoskeleton regulator RNA (CYTOR) modulates pathological cardiac hypertrophy through miR-155-mediated IKKi signaling.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 19. Epub 2019 Feb 19.

Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 430060, China; Department of Cardiology, The Fifth Affiliated Hospital of Xin Jiang Medical University, Urumchi 830001, China; Qianjiang Central Hospital of Hubei Province, Qianjiang 433100, China. Electronic address:

Pathological cardiac hypertrophy, which may lead to heart failure and sudden death, can be affected by multiple factors. In our previous study, we revealed that IKKi deficiency induced cardiac hypertrophy through the activation of the AKT and NF-kB signaling pathway in response to aortic banding (AB). Non-coding RNAs, mainly long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), play a crucial role in normal developmental and pathological processes. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.014DOI Listing
February 2019

Psychophysiological and performance-related responses of a potentiation activity in swimmers of different competitive levels.

Physiol Behav 2019 Feb 19. Epub 2019 Feb 19.

Faculty of Physical Education & Sport Sciences, School of Physical Education & Sport Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Athletes' competitive level has an effect on several psychophysiological parameters during the execution of sports-related tasks. This study analyzed the acute effect of a potentiation activity (PAP), composed by 5 loaded box jumps, on specific psychological, physiological and performance-related parameters in 22 trained (COM) and untrained (UNT) adult male swimmers. A control condition was also evaluated. Read More

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http://dx.doi.org/10.1016/j.physbeh.2019.02.018DOI Listing
February 2019

Meta-analyses of the effects of Dpp-4 inhibitors, SGLT2 inhibitors and GLP1 receptor analogues on cardiovascular death, myocardial infarction, stroke and hospitalization for heart failure.

Diabetes Res Clin Pract 2019 Feb 19. Epub 2019 Feb 19.

Consultant Endocrinologist. Nightingale Hospital, Kolkata, India.

Aim: To assess the effects DPP- 4i; SGLT2-i & GLP1-RA on CV death, MI, stroke and hHF . This is probably the first meta-analysis to assess the effects of these drugs on MI and stroke in totality, including non-fatal & fatal MI and stroke.

Methods: Scientific databases were searched for RCTs with pre-specified inclusion criteria and each end-point from the selected 13 studies was reported as an effect size (M H odds ratio) with a 95% confidence interval P value. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.02.014DOI Listing
February 2019

Severe Migraine Associated with Nickel allergy requiring surgical removal of atrial septal device.

Ann Thorac Surg 2019 Feb 19. Epub 2019 Feb 19.

Paediatric Cardiology Services, Royal Brompton Hospital and Harefield NHS Foundation Trust, National Heart and Lung Institute, Imperial College London.

Few patients experience migraines following transcatheter closure of secundum atrial septal defects using nitinol devices. These are usually treated with analgesics and resolve after a few months as the device endothelialises. We report a 16 years-old male who required surgical explantation of the device 6 years after closure because of debilitating headaches. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.034DOI Listing
February 2019

Transcatheter Aortic Valve Explantation is Usually Feasible and Easy.

Ann Thorac Surg 2019 Feb 19. Epub 2019 Feb 19.

Instituto de Investigación Sanitaria del Principado de Asturias. Oviedo. Spain; Heart Area. Hospital Universitario Central de Asturias. Oviedo. Spain; University of Oviedo. Oviedo. Spain.

We present a clinical case of a 59 year-old patient with a degenerated CoreValve aortic prosthesis. We provide a video of a previously described surgical technique to perform a late surgical explantation of a CoreValve. We confirm that this operation is feasible and easy, partly due to the absence of adhesions at the coronary ostia. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.035DOI Listing
February 2019

A Watershed Finding for Heart Regeneration.

Cell 2019 Feb;176(5):947-949

Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

The adult mammalian heart is minimally regenerative after injury, whereas neonatal hearts fully recover even after major damage. New work from the Red-Horse and Woo labs (Das et al., 2019) shows that collateral artery formation is a key mechanism contributing to successful regeneration in newborn mice and provides insights into how collateral arteries form. Read More

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http://dx.doi.org/10.1016/j.cell.2019.01.053DOI Listing
February 2019

Regulation of MicroRNA Machinery and Development by Interspecies S-Nitrosylation.

Cell 2019 Feb;176(5):1014-1025.e12

Institute for Transformative Molecular Medicine and Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA. Electronic address:

Bioactive molecules can pass between microbiota and host to influence host cellular functions. However, general principles of interspecies communication have not been discovered. We show here in C. Read More

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http://dx.doi.org/10.1016/j.cell.2019.01.037DOI Listing
February 2019

Inclusion in the clinical learning environment: Building the conditions for diverse human flourishing.

Med Teach 2019 Feb 22:1-5. Epub 2019 Feb 22.

b Department of Field Activities , Accreditation Council for Graduate Medical Education , Chicago , IL.

Aim: While diversity, equity, and inclusion are much proclaimed aspirational goals in education programs, the clinical learning environment (CLE) frequently falls short of meaningful incorporation of these concepts in processes, policies, and local culture. In this paper, we explore how inclusion, diversity, and equity can and should be defined and operationalized within medical education.

Methods: Three cases, organized around Hafferty's curricular framework (formal, informal, and hidden), we illustrate lapses and potential best practices in inclusion in the CLE. Read More

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http://dx.doi.org/10.1080/0142159X.2019.1566600DOI Listing
February 2019

A potential key mechanism in ascending aortic aneurysm development: Detection of a linear relationship between MMP-14/TIMP-2 ratio and active MMP-2.

PLoS One 2019 22;14(2):e0212859. Epub 2019 Feb 22.

Department of Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University of Freiburg, Freiburg, Germany.

Objectives: Elevated matrix metalloproteinase-2 (MMP-2) tissue levels have been associated with ascending thoracic aortic aneurysm (aTAA). As MMP-2 activation is controlled by interactions among matrix metalloproteinase-14 (MMP-14), a tissue inhibitor of metalloproteinases-2 (TIMP-2) and Pro-MMP-2 in cell culture, this activation process might also play a role in aTAA.

Methods: Via gelatin zymography we analyzed tissue levels of MMP-2 isoforms (Pro-MMP-2, active MMP-2, total MMP-2) and via enzyme-linked immunosorbent assay (ELISA,) MMP-14,TIMP-2 and total MMP-2 tissue levels in N = 42 patients with aTAA. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212859PLOS
February 2019

Impact of a selective cyclooxygenase-2 inhibitor, celecoxib, on cortical excitability and electrophysiological properties of the brain in healthy volunteers: A randomized, double-blind, placebo-controlled study.

PLoS One 2019 22;14(2):e0212689. Epub 2019 Feb 22.

Department of Neurology, Comprehensive Epilepsy Center, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Seoul, South Korea.

The inflammatory response is considered a defence mechanism against physical or infectious insults and is prevalent within the central nervous system. Seizures also result in a robust inflammatory cascade, leading to enhanced activation of excitatory synaptic networks. Ample evidence based on animal models of epilepsy has demonstrated that celecoxib, a highly selective inhibitor of cyclooxygenase-2, has anticonvulsant effects. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212689PLOS
February 2019

Transcranial Direct Current Stimulation of motor cortex enhances running performance.

PLoS One 2019 22;14(2):e0211902. Epub 2019 Feb 22.

College of Sport Sciences, Chung-Ang University, Anseong, Gyoenggi, South Korea.

Transcranial direct current stimulation (tDCS) is a technique used to modulate neuronal excitability through non-invasive brain stimulation that can enhance exercise performance. We hypothesize that tDCS would improve submaximal running time to exhaustion (TTE) and delay the increase in the rating of perceived exertion (RPE) over time. We also hypothesize that tDCS would not lead to difference in cardiorespiratory responses. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211902PLOS
February 2019

A quantitative exploration of gastrointestinal bleeding in intensive care unit patients.

PLoS One 2019 22;14(2):e0212040. Epub 2019 Feb 22.

Department of Medicine, Columbia University Medical Center, New York, NY, United States of America.

Background: Quantitative assessments of the severity of bleeding in patients with bleeds within the gastrointestinal tract (GIB) are generally limited to blood tests like the hematocrit. The varied and irregular nature of the data collected during such observations makes it difficult in retrospective data analysis to characterize the complete course of bleeding. We intend to quantify the rate of blood loss over the course of an ICU stay, facilitating more precise analysis of retrospective data, and to use this quantification to examine questions about the effects of GIB. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212040PLOS
February 2019

Association of maternal disease and medication use with the risk of congenital heart defects in offspring: a case-control study using logistic regression with a random-effects model.

J Perinat Med 2019 Feb 22. Epub 2019 Feb 22.

National Center for Birth Defect Monitoring, Department of Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

Objective To examine the association between maternal diseases and congenital heart defects (CHDs) and to evaluate whether those associations vary with corresponding medication use. Methods A multi-hospital case-control study conducted from February 2010 to December 2014 analysed 916 controls and 1236 cases. Participating mothers were asked whether they suffered from influenza, common cold, herpes and threatened abortion or had used corresponding medication during the periconception period or the early pregnancy period. Read More

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http://dx.doi.org/10.1515/jpm-2018-0281DOI Listing
February 2019

FeetBeat: A Flexible Iontronic Sensing Wearable Detects Pedal Pulses and Muscular Activities.

IEEE Trans Biomed Eng 2019 Feb 19. Epub 2019 Feb 19.

Objective: Human feet have long been considered in close association with whole-body health, from which abundant cardiovascular and skeletomuscular information can be extracted. In this study, we aim to develop the world's first foot-based wearable system that can detect both pedal pulses and muscular activities, referred to as FeetBeat.

Methods: Utilizing the flexible iontronic sensing (FITS) technology, we have constructed and characterized a five-unit sensing array for detection of both pedal pulse signals and muscular activities. Read More

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http://dx.doi.org/10.1109/TBME.2019.2900224DOI Listing
February 2019

Relation between resting sympathetic outflow & vasoconstrictor responses to sympathetic nerve bursts: sex differences in healthy young adults.

Am J Physiol Regul Integr Comp Physiol 2019 Feb 22. Epub 2019 Feb 22.

Department of Kinesiology and Applied Physiology, University of Delaware, United States.

Previous studies have demonstrated an inverse relation between resting muscle sympathetic nerve activity (MSNA) and vasoconstrictor responsiveness (i.e., sympathetic transduction), such that those with high resting MSNA have low vascular responsiveness and vice-versa. Read More

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http://dx.doi.org/10.1152/ajpregu.00305.2018DOI Listing
February 2019

Reactive oxygen species modulate sodium-coupled neutral amino acid transporter 1 (SNAT1) expression in piglet pulmonary artery endothelial cells.

Am J Physiol Heart Circ Physiol 2019 Feb 22. Epub 2019 Feb 22.

Department of Pediatrics, University of Utah Health, United States.

Rationale: We have previously shown that the sodium-coupled neutral amino acid transporter, SNAT1, modulates NO production in pulmonary arterial endothelial cells (PAECs) from newborn piglets. Specifically, the ability to increase NO production in response to the L-arginine-NO precursor, L-citrulline is dependent on SNAT1 expression. Elucidating factors that regulate SNAT1 expression in PAEC could provide new insights and therapeutic targets relevant to NO production. Read More

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http://dx.doi.org/10.1152/ajpheart.00674.2018DOI Listing
February 2019

Reflected hemodynamic waves influence the pattern of Doppler ultrasound waveforms along the umbilical arteries.

Am J Physiol Heart Circ Physiol 2019 Feb 22. Epub 2019 Feb 22.

Hospital for Sick Children / University of TOronto, Canada.

The pulsatile pattern of blood motion measured by Doppler ultrasound within the umbilical artery is known to contain useful diagnostic information and is widely used to monitor pregnancies at risk of fetal growth restriction or stillbirth. Animal studies have identified reflected pressure waves travelling counter to the direction of blood flow as an important factor in the shape of these waveforms. In the present study, we establish a method to measure reflected waves in the human umbilical artery and assess their influence on blood velocity pulsation. Read More

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http://dx.doi.org/10.1152/ajpheart.00704.2018DOI Listing
February 2019

Non-Invasive Imaging Biomarker Identifies Small Airway Damage in Severe COPD.

Am J Respir Crit Care Med 2019 Feb 22. Epub 2019 Feb 22.

University of Michigan, Pulmonary & Critical Care, Ann Arbor, Michigan, United States ;

Rationale: Evidence suggests damage to small airways is a key pathologic lesion in chronic obstructive pulmonary disease (COPD). Computed Tomography (CT) densitometry has been demonstrated to identify emphysema, but no such studies have been performed linking an imaging metric to small airway abnormality.

Objectives: To correlate ex vivo Parametric Response Mapping (PRM) analysis to in vivo lung tissue measurements of patients with severe COPD treated by lung transplantation and controls. Read More

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http://dx.doi.org/10.1164/rccm.201811-2083OCDOI Listing
February 2019

Prognostic value of the estimated glomerular filtration rate decline in hypertensive patients without chronic kidney disease.

Am J Hypertens 2019 Feb 22. Epub 2019 Feb 22.

CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain.

Background: Our objective of this study was to determine if rate of eGFR decline and its intensity was associated with cardiovascular risk and death in hypertensive patients whose baseline estimated glomerular filtration rate (eGFR) was higher than 60 mL/min/1.73m2.

Methods: This study comprised 2,516 hypertensive patients who had had at least two serum creatinine measurements over a four-year period. Read More

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http://dx.doi.org/10.1093/ajh/hpz029DOI Listing
February 2019

Occupational medicine and occupational psychology: a rendezvous in Milan after World War II.

Med Lav 2019 Feb 22;110(1):63-74. Epub 2019 Feb 22.

Dipartimento di Scienze Cliniche e di Comunità. Università degli Studi di Milano.

Background: In the 1950s, occupational medicine and occupational psychology found a common field of action in the Clinica del Lavoro in Milan. OBJECTIVES This study aims to analyze and document how this encounter took place and, in particular, the contribution of the Clinica del Lavoro to the development of occupational psychology in Italy.

Methods: Historical sources of that period were investigated. Read More

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http://dx.doi.org/10.23749/mdl.v110i1.7799DOI Listing
February 2019

Examining the Utility of 30-day Readmission Rates and Hospital Profiling in the Veterans Health Administration.

J Hosp Med 2019 Feb 20;14:E1-E6. Epub 2019 Feb 20.

Department of Medicine, University of California, San Francisco, California.

Background: The Veterans Health Administration (VA) reports hospital-specific 30-day risk-standardized readmission rates (RSRRs) using CMS-derived models.

Objective: The aim of this study was to examine and describe the interfacility variability of 30-day RSRRs for acute myocardial infarction (AMI), heart failure (HF), and pneumonia as a means to assess its utility for VA quality improvement and hospital comparison.

Research Design: A retrospective analysis of VA and Medicare claims data using one-year (2012) and three-year (2010-2012) data given their use for quality improvement or for hospital comparison, respectively. Read More

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http://dx.doi.org/10.12788/jhm.3155DOI Listing
February 2019

The Association of Very Early Serum levels of S100B, GFAP, UCH-L1, and SBDP with Outcome in ProTECT III.

J Neurotrauma 2019 Feb 22. Epub 2019 Feb 22.

Emory University, Emergency Medicine , Emergency Medicine Research Center , 49 Jesse Hill Jr. Dr. , Atlanta, Georgia, United States , 30303 ;

Rapid risk-stratification of patients with acute traumatic brain injury (TBI) would inform management decisions and prognostication. The objective of this serum biomarker study (BIO-ProTECT) was to test the hypothesis that serum biomarkers of structural brain injury, measured at a single very early timepoint, add value beyond relevant clinical covariates when predicting unfavorable outcome 6-months after moderate-to-severe acute TBI. BIO-ProTECT utilized prospectively collected samples obtained from subjects with moderate-to-severe TBI enrolled in the ProTECT III clinical trial of progesterone. Read More

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http://dx.doi.org/10.1089/neu.2018.5809DOI Listing
February 2019

Top Ten Tips Palliative Care Clinicians Should Know About Caring for Patients with Left Ventricular Assist Devices.

J Palliat Med 2019 Feb 22. Epub 2019 Feb 22.

3 Division of Gerontology, Geriatrics and Pallative Care, University of Alabama-Birmingham and Section of Pallative Care, Birmingham VA Medical Center, Birmingham, Alabama.

Advanced heart failure (HF) is a common condition that leads to significant suffering for patients and their families. Left ventricular assist devices (LVADs) can improve both the quantity and quality of life for those suffering with advanced HF. Palliative care clinicians are being asked with increasing frequency to assist HF teams to manage patients with LVADs in the preimplantation, post-operative, and end-of-life settings, although not all palliative care providers feel comfortable with this technology. Read More

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http://dx.doi.org/10.1089/jpm.2019.0044DOI Listing
February 2019

Comparable effect of tolvaptan in heart failure patients with preserved or reduced ejection fraction.

Clin Exp Hypertens 2019 Feb 22:1-8. Epub 2019 Feb 22.

a Department of Cardiovascular Medicine , Toho University Graduate School of Medicine , Tokyo , Japan.

Background: It is unclear that the difference in efficacy of tolvaptan (TLV) on the length of hospital stay for both heart failure (HF) preserved ejection fraction (EF) (HFpEF) and reduced EF (HFrEF) patients.

Methods: We investigated 369 patients who were hospitalized with HF from February 2011 to June 2016 and initiated TLV. Patients who died in hospital, transferred hospital or clinical scenario 4 or 5 were excluded. Read More

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http://dx.doi.org/10.1080/10641963.2019.1583244DOI Listing
February 2019

The Impact of Physiological Factors on 30-day Unplanned Rehospitalization in Adults with Heart Failure.

J Community Health Nurs 2019 Jan-Mar;36(1):31-41

b UNC Greensboro School of Nursing , University of North Carolina Greensboro , Greensboro , NC , USA.

Heart failure (HF) patients have high rates of 30-day unplanned rehospitalization. This study assessed the impact of physiological factors on 30-day HF unplanned rehospitalization.

Methods: The cross-sectional study used secondary data from electronic medical records of 270 patients. Read More

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http://dx.doi.org/10.1080/07370016.2018.1555308DOI Listing
February 2019

Gestational jet lag predisposes to later-life skeletal and cardiac disease.

Chronobiol Int 2019 Feb 22:1-15. Epub 2019 Feb 22.

a Department of Molecular Genetics , University Medical Center Rotterdam , Rotterdam , The Netherlands.

Circadian rhythm disturbance (CRD) increases the risk of disease, e.g. metabolic syndrome, cardiovascular disease, and cancer. Read More

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http://dx.doi.org/10.1080/07420528.2019.1579734DOI Listing
February 2019

Angiotensin II-induced Hypertension and Cardiac Hypertrophy are Differentially Mediated by TLR3- and TLR4-Dependent Pathways.

Am J Physiol Heart Circ Physiol 2019 Feb 22. Epub 2019 Feb 22.

Internal Medicine-CCOM, University of Iowa, United States.

Toll-like receptors (TLR) are key components of the innate immune system that elicit inflammatory responses through the adaptor proteins MyD88 (myeloid differentiation protein 88)- and TRIF (toll-interleukin receptor domain-containing adaptor protein-inducing interferon-β). Previously we demonstrated that TRIF mediates the signaling of angiotensin II (Ang II)- induced hypertension and cardiac hypertrophy. Since TRIF is activated selectively by TLR3 and TLR4, our goals in this study were to determine the roles of TLR3 and TLR4 in mediating Ang II-induced hypertension and cardiac hypertrophy, and associated changes in proinflammatory gene expression in heart and kidney. Read More

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http://dx.doi.org/10.1152/ajpheart.00697.2018DOI Listing
February 2019

Effect of acarbose on cardiovascular events and new-onset diabetes in patients with coronary heart disease and impaired glucose tolerance.

Authors:
Yidong Wei Wen Xu

Future Cardiol 2019 Feb 22. Epub 2019 Feb 22.

Department of Endocrinology & Metabolism, Guangdong Provincial Key Laboratory of Diabetology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China.

Many studies indicated postprandial hyperglycemia was closely related to the development of diabetes and the risk of cardiovascular disease. Acarbose was shown to delay the onset of diabetes in people with impaired glucose tolerance that was at low cardiovascular risk. The Acarbose Cardiovascular Evaluation (ACE) trial formally evaluated whether acarbose could reduce the frequency of cardiovascular events in patients with established coronary heart disease and impaired glucose tolerance, and whether the incidence of Type 2 diabetes could be reduced. Read More

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http://dx.doi.org/10.2217/fca-2018-0062DOI Listing
February 2019

Necrotizing enterocolitis.

Neurogastroenterol Motil 2019 Mar;31(3):e13569

Department of Pediatrics and Human Development, Division of Neonatology, Michigan State University, East Lansing, Michigan.

Necrotizing enterocolitis (NEC) is an acute inflammatory disease of the intestine which primarily affects preterm infants and is a leading cause of morbidity and mortality in the neonatal intensive care unit. From a clinical standpoint, and during the early course of the disease, NEC can be difficult to distinguish from other diseases and conditions common to the preterm infant, and this warrants the need for specific disease biomarkers. The pathogenesis of NEC is only partly understood but likely involves an altered intestinal barrier immune response to feeding and the developing microbiome. Read More

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http://dx.doi.org/10.1111/nmo.13569DOI Listing

Relationship between the Kihon Checklist and the clinical parameters in patients who participated in cardiac rehabilitation.

Geriatr Gerontol Int 2019 Feb 22. Epub 2019 Feb 22.

Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Aim: The Kihon Checklist is a useful screening tool for assessing frailty in older individuals. However, the clinical significance of the Kihon Checklist in cardiac rehabilitation patients remains unclear. The present study aimed to evaluate the relationship between the Kihon Checklist and the clinical parameters in patients who participated in cardiac rehabilitation. Read More

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http://dx.doi.org/10.1111/ggi.13617DOI Listing
February 2019

Echocardiographic indices and severity of mitral regurgitation in dogs with preclinical degenerative mitral valve disease.

J Vet Intern Med 2019 Feb 22. Epub 2019 Feb 22.

Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Background: Describing severity of mitral regurgitation (MR) in dogs with degenerative mitral valve disease (DMVD) is challenging.

Hypothesis/objectives: Mitral regurgitant fraction (RF), effective regurgitant orifice area (EROA), and the ratio of mitral regurgitant to aortic flow (Q :Q ) can be calculated from routine echocardiographic measurements and provide additional information regarding MR severity.

Animals: Fifty-seven dogs with preclinical DMVD including 36 without and 21 with cardiomegaly. Read More

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http://dx.doi.org/10.1111/jvim.15461DOI Listing
February 2019

A common neural substrate for elevated PTSD symptoms and reduced pulse rate variability in combat-exposed veterans.

Psychophysiology 2019 Feb 22:e13352. Epub 2019 Feb 22.

Center for Healthy Minds, University of Wisconsin-Madison, Madison, Wisconsin.

Previous studies have identified reduced heart rate variability (HRV) in post-traumatic stress disorder (PTSD), which may temporally precede the onset of the disorder. A separate line of functional neuroimaging research in PTSD has consistently demonstrated hypoactivation of the ventromedial prefrontal cortex (vmPFC), a key aspect of a descending neuromodulatory system that exerts inhibitory control over heart rate. No research to date, however, has simultaneously investigated whether altered vmPFC activation is associated with reduced HRV and elevated PTSD symptoms in the same individuals. Read More

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http://dx.doi.org/10.1111/psyp.13352DOI Listing
February 2019

Ajmaline infusion during automated screening in Brugada syndrome and spontaneous Type 1 electrocardiogram unmasks non-suitability for subcutaneous implantable cardioverter-defibrillator.

Eur Heart J 2019 Feb 21. Epub 2019 Feb 21.

Cardiology Department, Fondazione Cardiocentro Ticino, Via Tesserete 48, Lugano, Switzerland.

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http://dx.doi.org/10.1093/eurheartj/ehz049DOI Listing
February 2019

Mechanical left ventricular dispersion in aortic stenosis: another parameter within dispersed surrogates of myocardial function?

Eur Heart J Cardiovasc Imaging 2019 Feb 21. Epub 2019 Feb 21.

CHU Limoges, Hôpital Dupuytren, Service Cardiologie, Limoges, France.

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http://dx.doi.org/10.1093/ehjci/jez028DOI Listing
February 2019

Safety and efficiency of a common and simplified protocol for pacemaker and defibrillator surveillance based on remote monitoring only: a long-term randomized trial (RM-ALONE).

Eur Heart J 2019 Feb 21. Epub 2019 Feb 21.

Hospital Vall d`Hebron, Passeig de la Vall d'Hebron, Barcelona, Spain.

Aims: This trial aimed to evaluate the safety and efficiency of a common and simplified protocol for the surveillance of cardiac implantable electronic devices based on remote monitoring (RM) in patients with pacemakers (PMs) and implantable cardiac defibrillators (ICDs) for at least 24 months.

Methods And Results: The RM-ALONE is a multicentre prospective trial that randomly assigned 445 patients in two groups, both followed by RM: the home monitoring-only (HMo) based on RM + remote interrogations (RIs) every 6 months and the HM + IO that adds in-office evaluations every 6 months to RM. Four hundred and forty-five patients were enrolled in the study, 294 PMs and 151 ICDs recipients. Read More

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http://dx.doi.org/10.1093/eurheartj/ehz067DOI Listing
February 2019

Dabigatran dual therapy with ticagrelor or clopidogrel after percutaneous coronary intervention in atrial fibrillation patients with or without acute coronary syndrome: a subgroup analysis from the RE-DUAL PCI trial.

Eur Heart J 2019 Feb 21. Epub 2019 Feb 21.

Brigham and Women's Hospital, Heart and Vascular Center and Harvard Medical School, 75 Francis Street, Boston, MA, USA.

Aims: After percutaneous coronary intervention (PCI) in patients with atrial fibrillation, safety and efficacy with dabigatran dual therapy were evaluated in pre-specified subgroups of patients undergoing PCI due to acute coronary syndrome (ACS) or elective PCI, and those receiving ticagrelor or clopidogrel treatment.

Methods And Results: In the RE-DUAL PCI trial, 2725 patients were randomized to dabigatran 110 mg or 150 mg with P2Y12 inhibitor, or warfarin with P2Y12 inhibitor and aspirin. Mean follow-up was 14 months, 50. Read More

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http://dx.doi.org/10.1093/eurheartj/ehz059DOI Listing
February 2019

Low-Gradient Severe Mitral Stenosis: Hemodynamic Profiles, Clinical Characteristics, and Outcomes.

J Am Heart Assoc 2019 Mar;8(5):e010736

1 Department of Cardiovascular Medicine Mayo Clinic Rochester MN.

Background Optimal management of patients with severe mitral stenosis ( MS ) and low transmitral gradient is incompletely understood. Methods and Results We examined 101 consecutive patients with severe rheumatic MS (mitral valve area ≤1.5 cm) who underwent balloon valvuloplasty. Read More

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http://dx.doi.org/10.1161/JAHA.118.010736DOI Listing

Factors Affecting Pediatric Dyslipidemia Screening and Treatment.

Clin Pediatr (Phila) 2019 Feb 22:9922819832068. Epub 2019 Feb 22.

2 Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Identification and management of dyslipidemia in childhood can reduce future cardiovascular risk. We performed a retrospective cohort study of children ages 2 to 18 years during 2009 to 2013 to evaluate factors that affect screening and treatment of pediatric dyslipidemia related to 2011 National Heart, Lung, and Blood Institute (NHLBI) guidelines. Logistic regression analysis determined the impact of NHLBI-identified factors on odds of being screened, elevated low-density lipoprotein cholesterol (LDL-C), and receiving pharmacotherapy. Read More

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http://dx.doi.org/10.1177/0009922819832068DOI Listing
February 2019

Role of Gal-3 and H-FABP in the early diagnosis of acute coronary syndrome.

Bratisl Lek Listy 2019 ;120(2):124-130

Objectives: We aimed to compare the plasma levels of biomarkers such as: serum Gal-3, H-FABP, cTnI, and CK-MB in patients, who were admitted to the emergency room with chest pain, and to determine whether these biomarkers have early diagnostic value of acute coronary syndrome (ACS).

Methods: The study was performed in 60 patients aged ≥ 18 years, who were admitted to emergency room. These patients were divided into 3 groups: patients with STEMI (group I, n = 20), patients with NSTEMI (group II, n = 20), and patients with USAP (group III, n = 20). Read More

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http://dx.doi.org/10.4149/BLL_2019_020DOI Listing
January 2019

[Congenital heart block revealing a maternal systemic disease : pathophysiology and therapeutic approaches].

Rev Med Liege 2019 Feb;74(2):95-99

Service de Gynécologie-Obstétrique, CHU Liège, Belgique.

Immunologic congenital atrioventricular block is due to the presence of anti-SSA and anti-SSB antibodies in maternal blood. This pathology is often diagnosed when the status is irreversible and is consequently associated with a high morbi-mortality. Close monitoring for high risk pregnancies can help to diagnose first and second degrees heart block and treatments can be offered when the block is still reversible. Read More

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February 2019

Update on the Impact, Diagnosis and Management of Cardiovascular Autonomic Neuropathy in Diabetes: What Is Defined, What Is New, and What Is Unmet.

Diabetes Metab J 2019 Feb;43(1):3-30

Division of Endocrinology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

The burden of diabetic cardiovascular autonomic neuropathy (CAN) is expected to increase due to the diabetes epidemic and its early and widespread appearance. CAN has a definite prognostic role for mortality and cardiovascular morbidity. Putative mechanisms for this are tachycardia, QT interval prolongation, orthostatic hypotension, reverse dipping, and impaired heart rate variability, while emerging mechanisms like inflammation support the pervasiveness of autonomic dysfunction. Read More

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http://dx.doi.org/10.4093/dmj.2018.0259DOI Listing
February 2019

Validity and reliability of the Turkish version of the EmPHasis-10 questionnaire in patients with pulmonary hypertension.

J Eval Clin Pract 2019 Feb 22. Epub 2019 Feb 22.

Faculty of Health Sciences, Division of Physiotherapy and Rehabilitation, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Rationale, Aims, And Objectives: The aim of the study was to evaluate the reliability and validity of the Turkish version of the EmPHasis-10 questionnaire to ensure cultural adaptation.

Methods: This study involved translation, back translation, and cross-cultural adaptation. One hundred and one patients who were diagnosed as having pulmonary hypertension (PH) for at least 6 months were evaluated using the Turkish version of EmPHasis-10. Read More

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http://dx.doi.org/10.1111/jep.13115DOI Listing
February 2019

Expanding analytic possibilities in pediatric solid organ transplantation through linkage of administrative and clinical registry databases.

Pediatr Transplant 2019 Feb 21:e13379. Epub 2019 Feb 21.

Pediatric Cardiology, Monroe Carell Jr. Children's Hospital, Nashville, Tennessee.

Database linkage is a common strategy to expand analytic possibilities. Our group recently completed a linkage between the SRTR and PHIS databases for pediatric heart transplant recipients. The aim of this project was to expand the linkage between SRTR and PHIS to include liver, kidney, lung, heart-lung, and small bowel transplants. Read More

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http://dx.doi.org/10.1111/petr.13379DOI Listing
February 2019
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