1,430,986 results match your criteria Heart & Lung: The Journal of Acute and Critical Care[Journal]


Evaluating the Effect of Monitoring through Telephone (Tele-Monitoring) on Self-Care Behaviors and Readmission of Patients with Heart Failure after Discharge.

Appl Clin Inform 2019 Mar 17;10(2):261-268. Epub 2019 Apr 17.

Department of Nursing & Emergency Medicine, Dezful University of Medical Sciences, Dezful, Iran.

Background:  Heart failure is one of the serious cardiovascular diseases, which poses a global pandemic and places a heavy burden on health care systems worldwide. The incidence of this disease in Iran is higher than in other Asian countries. To reduce patients' complications, readmission rates, and health care expenditures, it is necessary to design interventions, which are culturally appropriate and based on community needs. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1685167
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http://dx.doi.org/10.1055/s-0039-1685167DOI Listing
March 2019
2 Reads

Outcome of inter-hospital transfer of patients on extracorporeal membrane oxygenation in Switzerland.

Swiss Med Wkly 2019 Apr 17;149:w20054. Epub 2019 Apr 17.

Clinic for Cardiovascular Surgery, University Heart Centre, Zurich, Switzerland.

Aims Of The Study: An extracorporeal membrane oxygenation system (ECMO), as a bridge to either recovery, a ventricular assist device (VAD), or heart or lung transplantation, may be the only lifesaving option for critically ill patients suffering from refractory cardiac, respiratory or combined cardiopulmonary failure. As peripheral hospitals may not offer ECMO treatment, tertiary care centres provide specialised ECMO teams for on-site implantation and subsequent patient transfer on ECMO to the tertiary hospital. This study reports the results of the largest ECMO transportation programme in Switzerland and describes its feasibility and safety. Read More

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http://dx.doi.org/10.4414/smw.2019.20054DOI Listing

Key Updates in Cardio-Nephrology from 2018: Springboard to a Bright Future.

Cardiorenal Med 2019 Apr 17;9(4):222-228. Epub 2019 Apr 17.

Baylor University Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1159/000498916DOI Listing

Synthesis and biological evaluation of pyrazolo[3,4-b]pyridine-3-yl pyrimidine derivatives as sGC stimulators for the treatment of pulmonary hypertension.

Eur J Med Chem 2019 Apr 10;173:107-116. Epub 2019 Apr 10.

State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, PR China; Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, PR China.

A series of new pyrazolo[3,4-b]pyridin-3-yl pyrimidine derivatives were synthesized and evaluated for the activation of sGC. Compared with riociguat, compound 13a exhibited equivalent in vitro activity on preconstricted rat thoracic aorta rings and in Rat heart Langendorff preparation. Compound 13a also showed acceptable PK profiles, which might become a promising candidate for the treatment of pulmonary hypertension. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.04.014DOI Listing

Improved Lovastatin Production by Inhibiting (+)-Geodin Biosynthesis in Aspergillus terreus.

N Biotechnol 2019 Apr 14. Epub 2019 Apr 14.

The University of Sydney, School of Chemical and Biomolecular Engineering, Australia.

Lovastatin is widely prescribed to reduce elevated levels of cholesterol and prevent heart-related diseases. Cultivation of Aspergillus terreus (ATCC 20542) with carbohydrates or low-value feedstocks such as glycerol produces lovastatin as a secondary metabolite and (+)-geodin as a by-product. An A. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18716784183167
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http://dx.doi.org/10.1016/j.nbt.2019.04.003DOI Listing
April 2019
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The γ Family of Cytokines: Basic Biology to Therapeutic Ramifications.

Immunity 2019 Apr;50(4):832-850

Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Metabolic, and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-1674, USA. Electronic address:

The common cytokine receptor γ chain, γ, is a component of the receptors for interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene encoding γ results in X-linked severe combined immunodeficiency in humans, and γ family cytokines collectively regulate development, proliferation, survival, and differentiation of immune cells. Here, we review the basic biology of these cytokines, highlighting mechanisms of signaling and gene regulation that have provided insights for immunodeficiency, autoimmunity, allergic diseases, and cancer. Read More

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http://dx.doi.org/10.1016/j.immuni.2019.03.028DOI Listing

Thrombin: A Gas Pedal Driving Innate Immunity.

Immunity 2019 Apr;50(4):1024-1026

Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Munich, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany. Electronic address:

Hemostasis and immunity were long considered entirely separate entities. In this issue of Immunity, Burzynski et al. (2019) find that thrombin, the key enzyme within the coagulation cascade, activates IL-1α, a central pleiotropic pro-inflammatory cytokine, to promote wound healing and platelet production following ectoderm injury. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10747613193009
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http://dx.doi.org/10.1016/j.immuni.2019.03.006DOI Listing
April 2019
1 Read

Pupillometric indices of locus-coeruleus activation are not modulated following single bouts of exercise.

Int J Psychophysiol 2019 Apr 14. Epub 2019 Apr 14.

Department of Kinesiology, Michigan State University, United States of America.

Single bouts of exercise have been observed to enhance numerous domains of cognition including inhibitory aspects of cognitive control and neuroelectric indices of attention. Given that the locus-coeruleus norepinephrine system regulates alertness and attention, this system may underlie these exercise-induced enhancements. The present study used pupillometry to examine the extent to which a single bout of exercise induces changes in aspects of locus-coeruleus activation, as well as the extent to which changes in locus-coeruleus activation were associated with changes in inhibition and neuroelectric indices of attention. Read More

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http://dx.doi.org/10.1016/j.ijpsycho.2019.04.004DOI Listing

Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1.

N Engl J Med 2019 Apr;380(16):1525-1534

From the Departments of Bone Marrow Transplantation and Cellular Therapy (E.M., B.T., W.J., S.G.), Hematology (S.Z., Z.M., J.C., J.D., X.T., B.Y.R., M.J.W., B.P.S.), Therapeutics Production and Quality (T.L., M.M.M.), Immunology (H.A., B.Y.), Pharmaceutical Sciences (S.J.C.), Biostatistics (G.K., C.L.), and Infectious Diseases (G.M.), St. Jude Children's Research Hospital, Memphis, TN; the Allergy and Clinical Immunology Division, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru (J.C.A.B.); the Department of Pediatrics, Allergy-Immunology Division, Children's Hospital Los Angeles, Los Angeles (J.A.C.), and the Department of Pediatrics, Division of Pediatric Allergy-Immunology-Bone Marrow Transplantation, University of California, San Francisco (UCSF) Benioff Children's Hospital, San Francisco (J.R.L.-B., J.M.P., M.J.C.) - both in California; the Department of Pediatrics, Pediatric Allergy and Immunology, University of New Mexico, Albuquerque (E.D.); University of Oklahoma Health Sciences Center, Tulsa (J.T.L.); Departamento de Pediatria da Universidade de Taubaté, Conselho Nacional de Medicina, São Paulo (A.C.M.A.); Copperfield Childcare, Claremont, South Africa (H.W.); and the Genetic Immunotherapy Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (S.S.D.R., H.L.M.).

Background: Allogeneic hematopoietic stem-cell transplantation for X-linked severe combined immunodeficiency (SCID-X1) often fails to reconstitute immunity associated with T cells, B cells, and natural killer (NK) cells when matched sibling donors are unavailable unless high-dose chemotherapy is given. In previous studies, autologous gene therapy with γ-retroviral vectors failed to reconstitute B-cell and NK-cell immunity and was complicated by vector-related leukemia.

Methods: We performed a dual-center, phase 1-2 safety and efficacy study of a lentiviral vector to transfer complementary DNA to bone marrow stem cells after low-exposure, targeted busulfan conditioning in eight infants with newly diagnosed SCID-X1. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1815408
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http://dx.doi.org/10.1056/NEJMoa1815408DOI Listing
April 2019
4 Reads

Protective effect of alpha-lipoic acid against apical periodontitis-induced cardiac injury in rats.

Eur J Oral Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Biochemistry, Faculty of Veterinary Medicine, Near East University, Nicosia, Mersin 10, Turkey.

This study was designed to assess the possible protective effect of alpha-lipoic acid (ALA) on apical periodontitis (AP)-induced cardiac injury. Wistar albino rats were randomized into four groups: control; ALA; AP; and ALA + AP. Rats of the control and ALA groups were not endodontically treated, but saline and ALA (100 mg kg ) were administered. Read More

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http://dx.doi.org/10.1111/eos.12618DOI Listing

Adverse risk factor trends limit gains in coronary heart disease mortality in Barbados: 1990-2012.

PLoS One 2019 17;14(4):e0215392. Epub 2019 Apr 17.

Population Health Research Institute, St. George's, University of London, London, United Kingdom.

Background: Although most countries face increasing population levels of obesity and diabetes their effect on coronary heart disease (CHD) mortality has not been often studied in small island developing states (SIDs) where obesity rates are among the highest in the world. We estimated the relative contributions of treatments and cardiovascular risk factors to the decline in CHD mortality from 1990 to 2012 in the Caribbean island, Barbados.

Methods: We used the IMPACT CHD mortality model to estimate the effect of increased coverage of effective medical/surgical treatments and changes in major CHD risk factors on mortality trends in 2012 compared with 1990. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215392PLOS

Causes of mortality in cases with extra nodal natural killer/T-cell lymphoma, nasal type: A cohort study.

PLoS One 2019 17;14(4):e0214860. Epub 2019 Apr 17.

Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.

Objective: Extra nodal natural killer/T-cell lymphoma (ENKTL), nasal type is a rare and highly aggressive type of non-Hodgkin's lymphoma (NHL) commonly presented in the nasal cavity or lymphatic system. However, the common causes of mortality in ENKTL remain unclear. We conducted a retrospective population-based cohort study to elucidate the different causes of mortality in ENKTL and illustrate the main causal and associated risk factors leading to death. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214860PLOS

To pool or not to pool? Trends and predictors of banking arrangements within Australian couples.

PLoS One 2019 17;14(4):e0214019. Epub 2019 Apr 17.

ARC Centre of Excellence for Children and Families over the Life Course, Institute for Social Science Research, The University of Queensland, Brisbane, Australia.

The study of domestic money goes at the heart of debates about independence and equality in intimate relationships. It provides an important window on the individualization of family life and how couples reconcile ideals around egalitarian marriage ideologies with enduring gender inequality in society and the labor market. This study approaches these issues from the prism of couples' banking arrangements (separate vs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214019PLOS
April 2019
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Pharmacokinetics of Cefazolin and Vancomycin in Infants Undergoing Open-Heart Surgery With Cardiopulmonary Bypass.

Anesth Analg 2019 May;128(5):935-943

Department of Anesthesiology, Perioperative and Pain Medicine, Division of Pediatric Cardiac Anesthesia, Stanford University School of Medicine, Stanford, California.

Background: Gram-positive bacteria account for nearly three-quarters of all surgical site infections. Antibiotic prophylaxis against these bacteria with cephalosporins or, in select circumstances, with vancomycin is considered standard of care for prevention of surgical site infections. There is little evidence to describe the optimal dosing regimen for surgical site infection prophylaxis in infants undergoing cardiac surgery, and a great deal of institutional variability exists in dosing prophylactic antibiotics. Read More

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http://dx.doi.org/10.1213/ANE.0000000000003876DOI Listing
May 2019
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LIMPRINT: The UK Experience-Subjective Control of Swelling in Patients Attending Specialist Lymphedema Services.

Lymphat Res Biol 2019 Apr;17(2):211-220

9 Centre for Research & Implementation of Clinical Practice, London, United Kingdom.

This study was undertaken as part of the UK LIMPRINT international study to determine the number of people with chronic edema (CO) and its impact on health services. Overall 7436 with CO were recruited in the main UK study from a range of health settings. Factors relating to subjective control of arm and leg CO were defined in the UK. Read More

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http://dx.doi.org/10.1089/lrb.2019.0020DOI Listing

LIMPRINT: Prevalence of Chronic Edema in Health Services in Copenhagen, Denmark.

Lymphat Res Biol 2019 Apr;17(2):187-194

1 Copenhagen Wound Healing and Lymphoedema Centre, Bispebjerg University Hospital, Copenhagen, Denmark.

The International Lymphedema Framework developed an international study, Lymphedema Impact and Prevalence International (LIMPRINT), to estimate the prevalence and impact of chronic edema (CO) in heterogeneous populations. A validation study using the LIMPRINT methodology was undertaken in Denmark. Participants with CO were identified from inpatient services and compared with those identified within a specialist lymphedema service and three primary care settings. Read More

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http://dx.doi.org/10.1089/lrb.2019.0019DOI Listing

LIMPRINT: Estimation of the Prevalence of Lymphoedema/Chronic Oedema in Acute Hospital in In-Patients.

Lymphat Res Biol 2019 Apr;17(2):135-140

1 Department of Vascular Medicine, EA2992, University of Montpellier, CHU Montpellier, Montpellier, France.

To estimate the prevalence of lymphedema/chronic edema (CO) and wounds in acute hospital inpatients in five different countries. A point-prevalence study was carried out during working day periods in six general hospitals in four countries (Denmark, France, United Kingdom, and Australia) and one hospital oncology inpatient unit in one other country (Ireland). The study used validated clinical tools for the assessment and collection of data. Read More

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http://dx.doi.org/10.1089/lrb.2019.0024DOI Listing

Prevalence and Risk Factors for Chronic Edema in U.K. Community Nursing Services.

Lymphat Res Biol 2019 Apr;17(2):147-154

2 Montpellier Medecine Vasculaire, EA2992, Universite Montpellier I, CHU Saint Eloi, Montpellier, France.

Chronic edema (CO) is believed to be a major clinical problem within community nursing services in the United Kingdom. This study was undertaken as part of the LIMPRINT international study to determine the number of people with CO and its impact on health services. Three urban-based community nursing services participated in the United Kingdom with prospective evaluation for 4 weeks of all patients receiving nursing care using a questionnaire-based interview and clinical assessment using the LIMPRINT tools. Read More

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https://www.liebertpub.com/doi/10.1089/lrb.2018.0086
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http://dx.doi.org/10.1089/lrb.2018.0086DOI Listing
April 2019
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Psychometric validation of Anti-Clot Treatment Scale and Treatment Satisfaction Questionnaire for Medication version II in Japanese patients with atrial fibrillation.

J Med Econ 2019 Apr 17. Epub 2019 Apr 17.

i Modus Outcomes Ltd , Letchworth Garden City , UK.

Aims: The Anti-Clot Treatment Scale (ACTS) and Treatment Satisfaction Questionnaire for Medication version II (TSQM-II) are validated treatment satisfaction patient-reported outcome (PRO) instruments. The ACTS includes two domains: Burdens and Benefits; the TSQM-II includes four: Effectiveness, Side Effects, Convenience, and Global Satisfaction. Japanese-language versions of the ACTS and TSQM-II have been developed and linguistically validated. Read More

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http://dx.doi.org/10.1080/13696998.2019.1609003DOI Listing

Long-term survivors of cardiac arrest: A narrative inquiry.

Eur J Cardiovasc Nurs 2019 Apr 17:1474515119844717. Epub 2019 Apr 17.

University of Newcastle, Port Macquarie, Australia.

Background: Despite extensive knowledge and research in cardiac health there is limited understanding in how a cardiac arrest influences the life of long-term survivors.

Objective: The aim of this study was to explore how long-term survivors of a cardiac arrest adjusted to their new reality, expressed in their re-storied narratives.

Methods: Seven individuals surviving a cardiac arrest 5-26 years ago were interviewed through in-depth conversations over a six-month period. Read More

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http://dx.doi.org/10.1177/1474515119844717DOI Listing

Drug-Eluting Stent Versus Coronary Artery Bypass Grafting for Diabetic Patients With Multivessel and/or Left Main Coronary Artery Disease: A Meta-Analysis.

Angiology 2019 Apr 17:3319719839885. Epub 2019 Apr 17.

1 Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.

With the development of stent design and surgical techniques, the relative benefit of percutaneous coronary intervention (PCI) versus coronary artery bypass grafting (CABG) in patients with diabetes and complex coronary artery disease are highly debated. This meta-analysis was conducted to compare the outcomes of drug-eluting stent (DES) implantation and CABG in these cohorts. A comprehensive search of PubMed, Embase, and Cochrane Library up to January 4, 2018, was performed. Read More

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http://dx.doi.org/10.1177/0003319719839885DOI Listing
April 2019
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mTORC1 is required for expression of LRPPRC and cytochrome c oxidase but not HIF-1α in Leigh Syndrome French Canadian Type Patient Fibroblasts.

Am J Physiol Cell Physiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Nutrition, Université de Montréal, Montréal, QC H3C 3J7, Canada. Department of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada.

Leigh syndrome French Canadian type (LSFC) is a mitochondrial disease caused by mutations in the LRPRRC gene leading to a reduction of cytochrome c oxidase (COX) expression reaching 50% in skin fibroblasts. We have shown that, under basal conditions, LSFC and control cells display similar ATP levels. We hypothesized that this occurs through upregulation of mechanistic target of rapamycin (mTOR)-mediated metabolic reprogramming. Read More

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http://dx.doi.org/10.1152/ajpcell.00160.2017DOI Listing

Reduced Left Ventricular Diastolic Function in Women with Post-Traumatic Stress Disorder.

Am J Physiol Regul Integr Comp Physiol 2019 Apr 17. Epub 2019 Apr 17.

Cardiology Division, Internal Medicine, UT Southwestern Medical Center, United States.

Women are 2-3 times more likely to develop post-traumatic stress disorder (PTSD) compared with men after exposure to a major trauma, and PTSD is associated with increased risk for cardiovascular disease in later life. The underlying mechanisms are unclear, but alterations in cardiac function may be involved. We hypothesized that women with PTSD have reduced left ventricular (LV) diastolic function. Read More

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https://www.physiology.org/doi/10.1152/ajpregu.00002.2019
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http://dx.doi.org/10.1152/ajpregu.00002.2019DOI Listing
April 2019
1 Read

Parallel multi-stream training of high-dimensional neural network potentials.

J Chem Theory Comput 2019 Apr 17. Epub 2019 Apr 17.

Over the past years high-dimensional neural network potentials (HDNNPs), fitted to accurately reproduce ab initio potential energy surfaces, have become a powerful tool in chemistry, physics and materials science. Here, we focus on the training of the neural networks that lies at the heart of the HDNNP method. We present an efficient approach for optimizing the weight parameters of the neural network via multi-stream Kalman filtering, using potential energies and forces as reference data. Read More

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http://dx.doi.org/10.1021/acs.jctc.8b01092DOI Listing

Cardiovascular Disease: Cardioverter-Defibrillators and Left Ventricular Assist Devices.

FP Essent 2019 Apr;479:30-34

Womack Army Medical Center Department of the Army, WAMC Stop A 2817 Reilly Rd, Ft Bragg, NC 28310-7301.

Sudden cardiac death (SCD) is an abrupt and unexpected death presumed to be due to cardiac causes. The primary etiologic mechanism is cardiac arrest due to an arrhythmia. Cardioverter-defibrillators detect abnormal arrhythmia and abort the rhythm with an electrical shock. Read More

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April 2019
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A cluster of acute rheumatic fever cases among Aboriginal Australians in a remote community with high baseline incidence.

Aust N Z J Public Health 2019 Apr 17. Epub 2019 Apr 17.

Northern Territory Centre for Disease Control, Northern Territory.

Objectives: We report a cluster of acute rheumatic fever (ARF) cases and the public health response in a high-burden Australian setting.

Methods: The public health unit was notified of an increase in ARF cases in a remote Australian Aboriginal community. A multi-disciplinary group coordinated the response. Read More

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http://dx.doi.org/10.1111/1753-6405.12893DOI Listing

The effects of parathyroid hormone-related peptide on cardiac angiogenesis, apoptosis, and function in mice with myocardial infarction.

J Cell Biochem 2019 Apr 17. Epub 2019 Apr 17.

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

It is known that parathyroid hormone-related peptide (PTHrP) contains a nuclear localization sequence (NLS, 87-107), which, together with its C-terminus (107-139), has been shown to positively regulate vascular smooth muscle cell (VSMCs) proliferation and vascular neointima formation, and inhibit cellular apoptosis. The role of PTHrP in ischemic cardiac diseases remains unclear. In this study, we attempted to determine whether PTHrP 87 to 139 can play a role in promoting cardiac function via enhancing angiogenesis after myocardial infarction (MI) occurred. Read More

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http://dx.doi.org/10.1002/jcb.28735DOI Listing

Thrombectomy of Ventricular Assist Device-Originated Embolic Stroke: A Clinical Decision Model.

J Neuroimaging 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurology, Loyola University Chicago, Stritch School of Medicine.

Background And Purpose: The use of ventricular assist devices (VADs) for the treatment of heart failure has become increasingly common. These patients have a considerable risk of cerebral embolism. We describe such a patient and his successful treatment by thrombectomy, compare his attributes with those previously published, and describe the construct of a clinical decision model, whose results bear practical implications for patient management. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jon.12621
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http://dx.doi.org/10.1111/jon.12621DOI Listing
April 2019
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Association between income and control of cardiovascular risk factors after acute coronary syndromes: an observational study.

Swiss Med Wkly 2019 Apr 17;149:w20049. Epub 2019 Apr 17.

Department of Ambulatory Care and Community Medicine, University of Lausanne, Switzerland.

Background: The role of income in cardiovascular disease prevention after an acute coronary syndrome (ACS) remains unclear. We aimed to assess the association between income and control of cardiovascular risk factors one year after an ACS in a country with universal health insurance.

Methods: Between 2013 and 2014, we studied 255 consecutive patients with ACS in an observational study in a university hospital in Switzerland in which self-reported household income was assessed. Read More

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http://dx.doi.org/10.4414/smw.2019.20049DOI Listing

Anatomic Relationship of the Complex Tricuspid Valve, Right Ventricle, and Pulmonary Vasculature: A Review.

JAMA Cardiol 2019 Apr 17. Epub 2019 Apr 17.

CARIM School for Cardiovascular Diseases, Maastricht University Medical Center/Maastricht University, Maastricht, the Netherlands.

Importance: Severe functional or secondary tricuspid regurgitation (TR) is associated with poor long-term outcomes in natural history studies as well as specific disease states. An understanding of the physiologic causes of the TR is lacking precluding a systematic approach to treatment.

Observations: The complex anatomic relationship between the tricuspid valve apparatus and structure of the right side of the heart lends insight into the functional changes seen with secondary TR. Read More

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http://dx.doi.org/10.1001/jamacardio.2019.0535DOI Listing

Critical analysis of the classic indications for myocardial revascularization.

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):319-325. Epub 2019 Apr 11.

Department of Atherosclerosis, Heart Institute of the Hospital das Clínicas of the Faculty of Medicine of USP (InCor-HCFMUSP), São Paulo, Brasil.

Treatment of stable coronary artery disease (CAD) relies on improved prognosis and relief of symptoms. National and international guidelines on CAD support the indication of revascularization in patients with limiting symptoms and refractory to optimal medical treatment, as well as in clinical situations where there is a prognostic benefit of interventional treatment. Most of the studies that support the guidelines for indication of revascularization date back to the 1980s and1990s of the last century. Read More

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http://dx.doi.org/10.1590/1806-9282.65.3.319DOI Listing
March 2019
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Dual platelet antiaggregation therapy after myocardial revascularization surgery.

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):316-318. Epub 2019 Apr 11.

Department of Atherosclerosis of the Heart Institute of the Hospital das Clínicas of the Faculty of Medicine of the University of São Paulo, São Paulo, Brasil.

Coronary artery bypass graft (CABG) is a consolidated treatment in patients with coronary artery disease (CAD) for both symptom control and improvement of prognosis. The patency of venous grafts is still the most vulnerable point of the surgical treatment since it presents a high prevalence of occlusion both in the immediate postoperative period and in the long-term follow-up. Aspirin plays a well-established role in this setting, and for a long time, clopidogrel use has been restricted to patients allergic to aspirin. Read More

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http://dx.doi.org/10.1590/1806-9282.65.3.316DOI Listing

Case 2/2019 - Man with Arrhythmogenic Cardiopathy Followed by Rapidly Progressive Heart Failure.

Arq Bras Cardiol 2019 Apr;112(4):466-472

Instituto do Coração (InCor) - Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP - Brazil.

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http://www.gnresearch.org/doi/10.5935/abc.20190065
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http://dx.doi.org/10.5935/abc.20190065DOI Listing
April 2019
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Quantification of Left Atrial Tissue Remodeling Using Intra-Atrial Dyssynchrony by Cardiac Magnetic Resonance Imaging.

Arq Bras Cardiol 2019 Apr;112(4):451-452

Minneapolis Heart Institute - Abbott Northwestern Hospital, Minneapolis - Minnesota.

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http://dx.doi.org/10.5935/abc.20190073DOI Listing

Efficacy, Safety, and Performance of Isolated Left vs. Right Ventricular Pacing in Patients with Bradyarrhythmias: A Randomized Controlled Trial.

Arq Bras Cardiol 2019 Apr 15;112(4):410-421. Epub 2019 Apr 15.

Instituto do Coração (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP - Brazil.

Background: Considering the potential deleterious effects of right ventricular (RV) pacing, the hypothesis of this study is that isolated left ventricular (LV) pacing through the coronary sinus is safe and may provide better clinical and echocardiographic benefits to patients with bradyarrhythmias and normal ventricular function requiring heart rate correction alone.

Objective: To assess the safety, efficacy, and effects of LV pacing using an active-fixation coronary sinus lead in comparison with RV pacing, in patients eligible for conventional pacemaker (PM) implantation.

Methods: Randomized, controlled, and single-blinded clinical trial in adult patients submitted to PM implantation due to bradyarrhythmias and systolic ventricular function ≥ 0. Read More

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http://dx.doi.org/10.5935/abc.20180275DOI Listing

Mapping aldehydic load in vivo by positron emission tomography with [F]NABF.

Chem Commun (Camb) 2019 Apr 17. Epub 2019 Apr 17.

Dept. of Biology, University of Ottawa, Ottawa, Ontario, Canada. and Dept. of Chemistry & Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada and University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

A new radiotracer, [18F]NA3BF3, capable of rapid, stable, and catalyst-free complexation of aldehydes in vivo is reported. [18F]NA3BF3 was shown to bind aldehydes in live subjects using locally administered aldehyde-presenting microparticles, and was then applied to mapping aldehydic load in a mouse model of sepsis. [18F]NA3BF3 may enable the direct investigation of the chemical biology of aldehydes in living subjects, and may open avenues for the adoption of endogenous aldehydic load as an imaging biomarker of inflammatory pathology. Read More

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http://xlink.rsc.org/?DOI=C9CC01831J
Publisher Site
http://dx.doi.org/10.1039/c9cc01831jDOI Listing
April 2019
1 Read

[Tricuspid regurgitation and indications for treatment].

G Ital Cardiol (Rome) 2019 Apr;20(4):27-35

Dipartimento Cardiovascolare, Azienda Sanitaria Universitaria Integrata di Trieste.

Tricuspid regurgitation is a frequent valvular heart disease, particularly in the elderly and in association with other left-sided heart diseases. It has an adverse prognostic impact, with progressively increasing mortality as the degree of regurgitation increases. Isolated or combined (with mitral and/or aortic) surgery remains the treatment of choice, provided operative risk is acceptable. Read More

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http://www.giornaledicardiologia.it/articoli.php?archivio=ye
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http://dx.doi.org/10.1714/3146.31276DOI Listing
April 2019
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[Functionality of mammary-coronary bypass grafts according to the data of intraoperative flowmetry].

Angiol Sosud Khir 2019 ;25(1):159-162

Department of Cardiovascular Surgery, Research Institute of Cardiology, Tomsk, Russia; Tomsk National Research Medical Centre of the Russian Academy of Sciences, Tomsk, Russia.

Improvement of surgical treatment for ischaemic heart disease is one of the main trends in modern medicine. After the operation of coronary bypass grafting, further functioning of blood flow in the grafts largely depends upon its domination over the native blood flow in the target coronary arteries. Therefore, intraoperative diagnosis of functional competence of coronary bypass grafts by means of flowmetry is currently of special importance. Read More

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http://dx.doi.org/10.33529/angio2019121DOI Listing
January 2019

[Use of topical haemostatic agents in cardiovascular surgery].

Angiol Sosud Khir 2019 ;25(1):131-142

Federal Centre of Cardiovascular Surgery under the RF Ministry of Public Health, Khabarovsk, Russia.

The problem of haemostasis in cardiovascular surgery is of current concern. Recent trends are towards increased use of topical haemostatic agents. Tachocomb has been used for more than 30 years in abdominal surgery and oncology. Read More

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http://dx.doi.org/10.33529/angio2019118DOI Listing
January 2019

[Efficacy and safety of micronized purified flavonoid fraction (MPFF) in treatment of venous diseases in geriatric patients].

Angiol Sosud Khir 2019 ;25(1):88-91

National Medical and Surgical Centre named after N.I. Pirogov under the RF Ministry of Public Health, Moscow, Russia.

Analysed herein is the experience with micronized purified flavonoid fraction (MPFF) in treatment of geriatric patients with decompensated forms of chronic venous diseases. A total of 218 geriatric patients were examined and treated. Of these, 132 patients had trophic disorders (C4-C6 class), including 40 patients found to have venous trophic ulcers (VTU). Read More

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http://dx.doi.org/10.33529/angio2019112DOI Listing
January 2019

[Analysis of flowmetric parameters of blood flow through coronary bypass grafts in high-risk surgical patients].

Angiol Sosud Khir 2019 ;25(1):53-57

Rostov State Medical University, Rostov-on-Don, Russia.

Coronary artery bypass grafting is a widely used cardiosurgical intervention which may be performed either on the arrested heart in conditions of artificial circulation or on the beating heart without artificial circulation. However, in a series of works, the results of bypass grafting using both techniques had no significant differences. In our article, we analyse the flowmetric parameters of blood flow through the coronary bypass grafts in high-surgical risk patients presenting with ischaemic heart disease and undergoing coronary artery bypass grafting in conditions of artificial circulation and on the beating heart. Read More

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http://dx.doi.org/10.33529/angio2019107DOI Listing
January 2019

Steroid-induced Bradycardia During Induction Chemotherapy in Children and Young Adults Diagnosed With Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma.

J Pediatr Hematol Oncol 2019 Apr 15. Epub 2019 Apr 15.

Pediatrics, Division of Pediatric Hematology and Oncology, Monroe Carell Jr Children's Hospital at Vanderbilt.

Systemic corticosteroids are widely used for the treatment of acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma. Anecdotal case reports demonstrate bradycardia in patients receiving corticosteroids; however, a more in-depth analysis is lacking. This study aimed to describe the incidence, timing, and outcomes of bradycardia in children with ALL receiving corticosteroids during induction chemotherapy at our center from 2010 to 2016. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001483DOI Listing
April 2019
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Effect of ischemic preconditioning on cardiovascular outcomes in patients with symptomatic coronary artery disease: a cohort study.

Coron Artery Dis 2019 Apr 15. Epub 2019 Apr 15.

Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil.

Background: Despite the powerful myocardial protection of ischemic preconditioning (IP) observed in experimental studies, it remains a challenge to observe such protection in humans. Thus, the aim of this study was to evaluate the possible effects of IP on clinical outcomes in patients with coronary artery disease (CAD).

Patients And Methods: In this cohort study, patients with multivessel CAD, preserved systolic ventricular function, and stable angina were prospectively selected. Read More

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http://dx.doi.org/10.1097/MCA.0000000000000748DOI Listing

Leisure-time cross-country skiing is associated with lower incidence of hypertension: a prospective cohort study.

J Hypertens 2019 Apr 15. Epub 2019 Apr 15.

Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.

Objective: The prospective relationship between cross-country skiing and hypertension is uncertain. We aimed to assess the associations of leisure time cross-country skiing habits with incident hypertension in a general population.

Methods: The frequency, average duration, and intensity of leisure cross-country skiing were assessed at baseline using a 12-month physical activity questionnaire in the Kuopio Ischemic Heart Disease prospective study of 1809 middle-aged men without hypertension. Read More

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http://dx.doi.org/10.1097/HJH.0000000000002110DOI Listing

Mood Prediction of Patients With Mood Disorders by Machine Learning Using Passive Digital Phenotypes Based on the Circadian Rhythm: Prospective Observational Cohort Study.

J Med Internet Res 2019 Apr 17;21(4):e11029. Epub 2019 Apr 17.

Korea University College of Medicine, Department of Psychiatry, Seoul, Republic of Korea.

Background: Virtually, all organisms on Earth have their own circadian rhythm, and humans are no exception. Circadian rhythms are associated with various human states, especially mood disorders, and disturbance of the circadian rhythm is known to be very closely related. Attempts have also been made to derive clinical implications associated with mood disorders using the vast amounts of digital log that is acquired by digital technologies develop and using computational analysis techniques. Read More

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http://dx.doi.org/10.2196/11029DOI Listing

Interruptive Versus Noninterruptive Clinical Decision Support: Usability Study.

JMIR Hum Factors 2019 Apr 17;6(2):e12469. Epub 2019 Apr 17.

Department of Medicine, New York University School of Medicine, New York, NY, United States.

Background: Clinical decision support (CDS) has been shown to improve compliance with evidence-based care, but its impact is often diminished because of issues such as poor usability, insufficient integration into workflow, and alert fatigue. Noninterruptive CDS may be less subject to alert fatigue, but there has been little assessment of its usability.

Objective: This study aimed to study the usability of interruptive and noninterruptive versions of a CDS. Read More

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http://dx.doi.org/10.2196/12469DOI Listing

Anesthesiological Management in Transcatheter Mitral Valve Repair With MitraClip: Beyond the EVEREST Criteria.

Semin Cardiothorac Vasc Anesth 2019 Apr 17:1089253219842650. Epub 2019 Apr 17.

1 AORN Ospedali dei Colli, Monaldi Hospital, Naples, Italy.

Percutaneous mitral valve repair with the MitraClip system recently emerged as a viable and less invasive therapeutic option in patients with severe mitral regurgitation deemed to be high-risk surgical candidates. Mitral valve morphology and geometry features are key elements for MitraClip eligibility. In the setting of functional mitral regurgitation, the presence of a leaflet coaptation gap due to advanced left ventricle remodeling can be a potential exclusion criterion for MitraClip therapy. Read More

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http://journals.sagepub.com/doi/10.1177/1089253219842650
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http://dx.doi.org/10.1177/1089253219842650DOI Listing
April 2019
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Skeletal Muscle mRNA Response to Hypobaric and Normobaric Hypoxia After Normoxic Endurance Exercise.

High Alt Med Biol 2019 Apr 17. Epub 2019 Apr 17.

1 Exercise Physiology Lab, University of Nebraska at Omaha, Omaha, Nebraska.

Ross, Caleb I., Robert J. Shute, Brent C. Read More

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http://dx.doi.org/10.1089/ham.2018.0147DOI Listing

Angstrom Scale Chemical Analysis of Metal Supported Trans- and Cis-Regioisomers by Ultrahigh Vacuum Tip-Enhanced Raman Mapping.

Nano Lett 2019 Apr 17. Epub 2019 Apr 17.

Real space chemical analysis of two structurally very similar components i.e. regioisomers lies at the heart of heterogeneous catalysis reactions, modern-age electronic devices and various other surface related problems in surface science and nanotechnology. Read More

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http://dx.doi.org/10.1021/acs.nanolett.9b00826DOI Listing
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