1,409,336 results match your criteria Heart & Lung: The Journal of Acute and Critical Care[Journal]


Tissue Oximetry Monitoring for Free Deep Inferior Epigastric Perforator Flap Viability: Factors to be Considered toward Optimizing Postoperative Outcome.

J Reconstr Microsurg 2018 Dec 17. Epub 2018 Dec 17.

Department of Plastic and Reconstructive Surgery, Catholic University Sacred Heart - Policlinico Agostino Gemelli, Rome, Italy.

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December 2018

Effect of Different Circuit Training on Cardiovascular Responses in Cirrhotic Patients.

Int J Sports Med 2018 Dec 17. Epub 2018 Dec 17.

Universidade Federal do Rio de Janeiro, School of Physical Education and Sports, Rio de Janeiro, Brazil.

The purpose of this study was to analyze and compare heart rate (HR), heart rate variability (HRV), and blood pressure (BP) responses during and after circuit resistance training with 1 min. (CIR1) vs. 2 min. Read More

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December 2018

Phenotypic Heterogeneity within Members of a Family Carrying the Same RBM20 Mutation R634W.

Cardiology 2018 Dec 17;141(3):150-155. Epub 2018 Dec 17.

Molecular Immunopathology and Histocompatibility Unit, Division of Molecular Genetics, Onassis Cardiac Surgery Center, Athens, Greece.

Objective: We present the genotypic and phenotypic characterization of a family displaying dilated cardiomyopathy (DCM).

Methods: The proband and his relatives underwent full cardiological assessment. Genetic analysis of the proband was performed with the use of next-generation sequencing technology. Read More

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December 2018

EDUCATIONAL SERIES IN CONGENITAL HEART DISEASE: Tetralogy of Fallot: diagnosis to long-term follow-up.

Authors:
R Bedair X Iriart

Echo Res Pract 2019 Mar;6(1):R9-R23

Department of Pediatric and Adult Congenital Cardiology, Hôpital Cardiologique du Haut-Lévêque, CHU de Bordeaux, Pessac, France.

Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart defect, affecting 3 in 10,000 live births. Surgical correction in early childhood is associated with good outcomes, but lifelong follow-up is necessary to identify the long-term sequelae that may occur. This article will cover the diagnosis of TOF in childhood, the objectives of surveillance through adulthood and the value of multi-modality imaging in identifying and guiding timely surgical and percutaneous interventions. Read More

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Epilepsy and seizures in children with congenital heart disease: A prospective study.

Seizure 2018 Nov 26;64:50-53. Epub 2018 Nov 26.

Clinique d'Investigation Neuro-Cardiaque (CINC), CHU Sainte-Justine, Montreal, Canada.

Purpose: Children with complex congenital heart disease (CHD) experience high incidence of perioperative seizures. Population-based studies also report high epilepsy co-morbidity in CHD. Given the increasing survival of patients with CHD and the interference of seizures and epilepsy with the long-term outcomes, characterizing them in this population is of high relevance. Read More

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November 2018

Urinary metals and leukocyte telomere length in American Indian communities: The Strong Heart and the Strong Heart Family Study.

Environ Pollut 2018 Dec 5;246:311-318. Epub 2018 Dec 5.

Area of Cardiometabolic and Renal Risk, Biomedical Research Institute Hospital Clinic of Valencia (INCLIVA), Valencia, Spain; Department of Environmental Health and Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institutes, Madrid, Spain.

Introduction: While several mechanisms may explain metal-related health effects, the exact cellular processes are not fully understood. We evaluated the association between leukocyte telomere length (LTL) and urine arsenic (ΣAs), cadmium (Cd) and tungsten (W) exposure in the Strong Heart Study (SHS, N = 1702) and in the Strong Heart Family Study (SHFS, N = 1793).

Methods: Urine metal concentrations were measured using ICP-MS. Read More

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December 2018

In vivo effects of serotonin and fluoxetine on cardio-ventilatory functions in the shore crab Carcinus maenas (L. 1758).

Aquat Toxicol 2018 Dec 5;207:132-141. Epub 2018 Dec 5.

Normandie Université, FR CNRS 3730 SCALE, UMR-I 02 Unité Stress Environnementaux et Biosurveillance des milieux aquatiques (SEBIO), Université Le Havre Normandie, 25 rue Philippe Lebon, F-76600, Le Havre, France. Electronic address:

Serotonin (5-HT) takes a key position in regulating vital functions, such as cardio-ventilatory activity, locomotion and behaviour. Selective serotonin reuptake inhibitors (SSRIs) modulate the serotonergic system and thus affect these functions. Rhythmic behaviours, such as cardio-ventilatory activity, are controlled by central pattern generators, which in turn are regulated by 5-HT. Read More

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December 2018

Contingent biofeedback outperforms other methods to enhance the accuracy of cardiac interoception: A comparison of short interventions.

J Behav Ther Exp Psychiatry 2018 Dec 4;63:12-20. Epub 2018 Dec 4.

Institute of Clinical Psychology and Psychotherapy, University of Cologne, Cologne, Germany. Electronic address:

Background And Objectives: Deviations in interoception might contribute to the development and maintenance of mental disorders. The improvement of interoceptive accuracy (IA) is desirable but assessment and training methods remain controversial. For instance, it was assumed that performance increases in heartbeat counting paradigms after cardiac feedback were due to an improvement of knowledge with regard to heart rate rather than due to an actual improvement in IA. Read More

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December 2018

Association between ambient particulate matter air pollution and ST-elevation myocardial infarction: A case-crossover study in a Chinese city.

Chemosphere 2018 Dec 12;219:724-729. Epub 2018 Dec 12.

Department of Cardiology, Yancheng Hospital Affiliated to Xuzhou Medical University and the First Hospital of Yancheng, Yancheng, 224006, China. Electronic address:

Background: Abundant epidemiological studies have revealed that short-term exposure to ambient air pollution increased the incidence of ischemic heart diseases. However, few investigations have explored the association between air pollution and ST-elevation myocardial infarction (STEMI), one major subtype of such events.

Methods: We conducted a time-stratified case-crossover study in two major hospitals of Yancheng, a city in East China, from January 2015 to February 2018. Read More

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December 2018

Comparison of International Systemic Adverse Reactions due to Allergen Immunotherapy.

J Allergy Clin Immunol Pract 2018 Dec 14. Epub 2018 Dec 14.

Section of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, Royal Brompton Hospital, London, UK.

Background: Several classifications of systemic adverse reactions (SAR) during allergen immunotherapy (AIT) have been proposed but the comparison of their usefulness in daily clinical practice is lacking.

Objective: The present post hoc analysis was aimed to investigate the practicality of the most relevant international classifications proposed by the European Academy of Allergology and Clinical Immunology (EAACI), the American Academy of Asthma, Allergology and Clinical Immunology /American College of Allergy, Asthma and Immunology (AAAACI/ACAAI), and the World Allergy Organization (WAO) using data provided by the longitudinal European Survey on Adverse Systemic Reactions in Allergen Immunotherapy (EASSI) based on daily clinical practice in 3 countries in Europe.

Methods: One hundred and nine SAR over 4363 AIT courses were classified as mild (n=78, 71. Read More

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December 2018
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Identifying sublethal endpoints for evaluating neurotoxic compounds utilizing the fish embryo toxicity test.

Ecotoxicol Environ Saf 2018 Dec 14;170:521-529. Epub 2018 Dec 14.

Department of Biology, Texas Christian University, Fort Worth, TX, USA. Electronic address:

Fish embryos are increasingly being utilized in aquatic toxicity testing, as evidenced by the Organisation for Economic Co-operation and Development's approval of the fish embryo acute toxicity (FET) test. However, the FET test only allows for the estimation of acute toxicity, whereas other test methods such as the larval growth and survival (LGS) test allow for the estimation of both acute and chronic toxicity. Additionally, it has been demonstrated that the FET test is less sensitive than other test methods for some neurotoxic compounds. Read More

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December 2018

KIT as a therapeutic target for non-oncological diseases.

Pharmacol Ther 2018 Dec 14. Epub 2018 Dec 14.

Aix Marseille Université, INSERM, INRA, C2VN, Marseille, France; Clinique des Bronches, Allergies et Sommeil, Hôpital Nord, AP-, HM, Marseille, France.. Electronic address:

KIT is a receptor tyrosine kinase that after binding to its ligand stem cell factor activates signaling cascades linked to biological processes such as proliferation, differentiation, migration and cell survival. Based on studies performed on SCF and/or KIT mutant animals that presented anemia, sterility, and/or pigmentation disorders, KIT signaling was mainly considered to be involved in the regulation of hematopoiesis, gametogenesis, and melanogenesis. More recently, novel animal models and ameliorated cellular and molecular techniques have led to the discovery of a widen repertoire of tissue compartments and functions that are being modulated by KIT. Read More

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December 2018

Mechanisms of cardiac ethanol toxicity and novel treatment options.

Pharmacol Ther 2018 Dec 14. Epub 2018 Dec 14.

Department of Internal Medicine II, University Medical Center Regensburg, Germany. Electronic address:

Ethanol can acutely and chronically alter cardiomyocyte and whole-organ function in the heart. Importantly, ethanol acutely and chronically predisposes to arrhythmias, while chronic abuse can induce heart failure. However, the molecular mechanisms of ethanol toxicity in the heart are incompletely understood. Read More

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December 2018

Eccentric Arm Cycling: A Potential Exercise for Wheelchair Users.

Arch Phys Med Rehabil 2018 Dec 14. Epub 2018 Dec 14.

Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, MI, USA; Department of Physical Therapy, Central Michigan University, Mt. Pleasant, MI, USA. Electronic address:

Objective: We compared metabolic, cardiorespiratory, and perceptual responses to acute eccentric (ECC) and traditional concentric (CON) arm cycling in a cohort of wheelchair users.

Design: Single-group repeated measures.

Setting: Exercise physiology laboratory. Read More

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December 2018

Variation in Implementation and Outcomes of Early Extubation Practices After Infant Cardiac Surgery.

Ann Thorac Surg 2018 Dec 14. Epub 2018 Dec 14.

Michigan Medicine C.S. Mott Children's Hospital, Department of Pediatrics, 1540 E. Hospital Drive, Ann Arbor, MI 48109.

Background: The Pediatric Heart Network Collaborative Learning Study (PHN CLS) increased early extubation after infant Tetralogy of Fallot (TOF) and coarctation repair overall at participating sites through implementing a clinical practice guideline (CPG). We evaluated variability across sites in CPG implementation and outcomes.

Methods: Patient characteristics and outcomes [time to extubation, length of stay (LOS)] were compared across sites, including pre- to post-CPG changes. Read More

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December 2018
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TUSARC PROGNOSTIC: Prognostic value of high sensitivity troponin T assay in asymptomatic high cardiovascular risk patients.

Am J Med 2018 Dec 14. Epub 2018 Dec 14.

Clinical testing laboratory, Hospital Santos Reyes Aranda de Duero Burgos, Spain.

Objectives: Prognostic value of high-sensitivity cardiac troponin T assays (hs-cTnT) have been carried out on selected populations in different studies and in registries of low cardiovascular risk general population. The aim of this study is to determine the prognostic value of hs-cTnT in a Spanish asymptomatic very high cardiovascular risk population.

Method: From previously prospective cohort of TUSARC (troponina T UltraSensible en pacientes Asintomáticos de alto Riesgo Cardiovascular) registry, follow up was done in 602 patients (93,18%). Read More

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December 2018
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Evidence for Fucoidan-P-selectin Axis as a Therapeutic Target on Hypoxia-induced Pulmonary Hypertension.

Am J Respir Crit Care Med 2018 Dec 17. Epub 2018 Dec 17.

Justus-Leibig-University, Internal Medicine, Giessen, Germany ;

Rationale: Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling and excessive proliferation of pulmonary artery smooth muscle cells (PASMCs). Fucoidan, polysacharidic ligand of an adhesion molecule P-selectin exhibits anti-proliferative properties. The effects of Fucoidan/P-selectin axis on vascular remodeling and pulmonary hypertension (PH) following hypoxia remain unexplored. Read More

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December 2018

Long-Term Outcomes Among Patients Discharged From the Hospital With Moderate Anemia: A Retrospective Cohort Study.

Ann Intern Med 2018 Dec 18. Epub 2018 Dec 18.

Kaiser Permanente Northern California, Oakland, California (D.G.M., C.L., P.K., V.X.L., G.J.E.).

Background: Randomized clinical trial findings support decreased red blood cell (RBC) transfusion and short-term tolerance of in-hospital anemia. However, long-term outcomes related to changes in transfusion practice have not been described.

Objective: To describe the prevalence of anemia at and after hospital discharge and associated morbidity and mortality events. Read More

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December 2018
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Empirically developed dietary inflammatory potential (EDIP) in patients candidate for coronary artery bypass grafting surgery (CABG): Association with metabolic parameters, dietary antioxidant quality score and dietary phytochemical index.

PLoS One 2018 17;13(12):e0208711. Epub 2018 Dec 17.

Department of Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

Aims: It has been suggested that empirically developed dietary inflammatory potential (EDIP) is a diagnostic tool for assessment of inflammatory potential of diet in prediction of risk factors related to chronic disease. In the current work, we examined the association between EDIP with cardio-metabolic risk factors, dietary antioxidant quality score (DAQs), dietary phytochemical index (DPI) and Mediterranean dietary quality index (MEDQI) in patients candidate for CABG.

Materials And Methods: In the current cross-sectional study, the data obtained from Tehran- Heart Center-Coronary Outcome Measurement (THC-COM) study from 454 patients candidate for the CABG were used. Read More

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December 2018
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Multimorbidity patterns in high-need, high-cost elderly patients.

PLoS One 2018 17;13(12):e0208875. Epub 2018 Dec 17.

Department of Statistical Sciences, University of Padova, Padova, Italy.

Introduction: Patients with complex health care needs (PCHCN) are individuals who require numerous, costly care services and have been shown to place a heavy burden on health care resources. It has been argued that an important issue in providing value-based primary care concerns how to identify groups of patients with similar needs (who pose similar challenges) so that care teams and care delivery processes can be tailored to each patient subgroup. Our study aims to describe the most common chronic conditions and their combinations in a cohort of elderly PCHCN. Read More

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December 2018
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Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study.

PLoS One 2018 17;13(12):e0208042. Epub 2018 Dec 17.

Department of Medicine, University of California San Francisco/ San Francisco VA Medical Center, San Francisco, California, United States of America.

Background: Patients with chronic kidney disease (CKD) are at increased risk for heart failure (HF). We aimed to investigate differences in proteins associated with HF hospitalizations among patients with and without CKD in the Heart and Soul Study.

Methods And Results: We measured 1068 unique plasma proteins from baseline samples of 974 participants in The Heart and Soul Study who were followed for HF hospitalization over a median of 7 years. Read More

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December 2018

The predictive value of Cardiodynamicsgram in myocardial perfusion abnormalities.

PLoS One 2018 17;13(12):e0208859. Epub 2018 Dec 17.

School of Automation Science and Engineering, South China University of Technology, Guangzhou, Guangdong, China.

Myocardial perfusion abnormalities are the first sign of the ischemic cascade in the development of coronary artery disease (CAD). Thus, the early detection of myocardial perfusion abnormalities is significant for the prevention of CAD. Recently, a novel noninvasive method named Cardiodynamicsgram (CDG) has been proposed for early detection of CAD. Read More

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December 2018
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Comparison of visual assessment and computer image analysis of intracoronary thrombus type by optical coherence tomography.

PLoS One 2018 17;13(12):e0209110. Epub 2018 Dec 17.

Heart Hospital, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.

Background: Analysis of intracoronary thrombus type by optical coherence tomography (OCT) imaging is highly subjective. We aimed to compare a newly developed image analysis method to subjective visual classification of thrombus type identified by OCT.

Methods: Thirty patients with acute ST elevation myocardial infarction were included. Read More

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December 2018

The authors reply.

Crit Care Med 2019 Jan;47(1):e66-e67

Department of Cardiology, Heart Institute (InCor), Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil Surgical Intensive Care Unit and Department of Anesthesiology, Heart Institute (InCor), Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy.

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January 2019

Correlation of serum tryptase levels with total number of nevi, Breslow thickness, ulceration, and mitotic index in melanoma patients: evaluation of a promising prognostic marker.

Melanoma Res 2018 Dec 15. Epub 2018 Dec 15.

Dermatologic Clinic, Departement of Internal Medicine and Medical Specialties, La Sapienza University of Rome.

Current evidences suggest that mast cells contribute to the proliferation and differentiation of skin melanocytes. According to these findings, we carried out an observational cross-sectional study to investigate the correlation between the total number of nevi (TN), Breslow thickness (BT), and serum tryptase (ST) levels in a cohort of 35 melanoma (MM) patients. A Mann-Whitney test was performed to compare ST values within each variable. Read More

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December 2018
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Major Adverse Cardiac Events and Mortality Associated with Electroconvulsive Therapy: A Systematic Review and Meta-analysis.

Anesthesiology 2019 Jan;130(1):83-91

From the Departments of Anesthesiology and Intensive Care (A.D., M.M., B.P.) Emergency Medicine (H.H.), Medical University of Vienna, Vienna, Austria the Department of Anesthesiology, Washington University, St. Louis, Missouri (P.N.) Department of Public Health Sciences, University of Chicago, University of Chicago, Illinois (T.K.).

What We Already Know About This Topic: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Cardiac events after electroconvulsive therapy have been reported sporadically, but a systematic assessment of the risk is missing. The goal of this study was to obtain a robust estimate of the incidence of major adverse cardiac events in adult patients undergoing electroconvulsive therapy.

Methods: Systematic review and meta-analysis of studies that investigated electroconvulsive therapy and reported major adverse cardiac events and/or mortality. Read More

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January 2019

Impact of preclinical carotid atherosclerosis on global cardiovascular risk stratification and events in a 10-year follow-up: comparison between the algorithms of the Framingham Heart Study, the European SCORE and the Italian 'Progetto Cuore'.

J Cardiovasc Med (Hagerstown) 2018 Dec 14. Epub 2018 Dec 14.

Chair and Division of Cardiology, University Hospital Policlinico 'Paolo Giaccone', Palermo, Italy.

Background: The aim of the study was to compare three widely used algorithms for stratification of the global cardiovascular risk (GCVR): the Framingham Heart Study (FHS) score, the European systemic coronary risk estimation (SCORE) and the Italian 'Progetto Cuore' (heart project) score. It was also investigated how preclinical carotid atherosclerosis (pre-ATS) might influence the incidence and improve the risk prediction of cerebrovascular and cardiovascular events.

Methods: Subjects (n = 358) without previous history of cardiovascular disease (CVD) were recruited and the GCVR was calculated for each patient. Read More

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December 2018

Abnormally high risk of stroke in Brugada syndrome.

J Cardiovasc Med (Hagerstown) 2018 Dec 14. Epub 2018 Dec 14.

Heart Rhythm Management Center, Postgraduate program in Cardiac Electrophysiology and Pacing.

Background: The present study sought to evaluate the incidence of cerebrovascular events in a large cohort of patients with Brugada syndrome (BrS) analysing possible predictors, clinical characteristics and prognosis of cardioembolic events secondary to atrial fibrillation.

Methods: A total of 671 consecutive patients (age 42.1 ± 17. Read More

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December 2018

Analysis of smoking behavior on the pharmacokinetics of antidepressants and antipsychotics: evidence for the role of alternative pathways apart from CYP1A2.

Int Clin Psychopharmacol 2018 Dec 14. Epub 2018 Dec 14.

Department of Psychiatry, Psychosomatics and Psychotherapy.

Smoking is common among psychiatric patients and has been shown to accelerate the metabolism of different drugs. We aimed to determine the effect of smoking on the serum concentrations of psychopharmacological drugs in a naturalistic clinical setting. Dose-corrected, steady-state serum concentrations of individual patients were analyzed retrospectively by linear regression including age, sex, and smoking for amitriptyline (n=503), doxepin (n=198), mirtazapine (n=572), venlafaxine (n=534), clozapine (n=106), quetiapine (n=182), and risperidone (n=136). Read More

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December 2018

The Transcriptional Signature of a Runner's High.

Med Sci Sports Exerc 2018 Dec 14. Epub 2018 Dec 14.

SUNY Upstate Medical University, Departments of Neuroscience & Physiology, Biochemistry & Molecular Biology, Pediatrics, and Psychiatry & Behavioral Sciences, Syracuse NY.

Introduction: Endorphins, endocannabinoids, monoamines, and neurotrophins have all been implicated in the euphoric response to endurance running, known as a runner's high. The epi-transcriptional mechanisms regulating this effect have not been defined. Here, we investigate peripheral micro-ribonucleic acid (miRNA) changes unique to athletes experiencing post-run euphoria, yielding insights about gene networks that control a runner's high. Read More

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December 2018

Internal and External Loads in Training Week Before the Competition in U19 High-Level Soccer Players.

J Strength Cond Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Physical Education and Sport, University of Granada, Granada, Spain.

Martín-López, Á, Mendes, RS, and Castillo-Rodríguez, A. Internal and external loads in training week before the competition in U19 high-level soccer players. J Strength Cond Res XX(X): 000-000, 2018-Nowadays, the information about the load in training sessions (TRs) and the relationship of these TRs with official competition are necessary to gain the sport success in soccer. Read More

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December 2018

Nonlinear Indices with Applications to Schizophrenia and Bipolar Disorder.

Nonlinear Dynamics Psychol Life Sci 2019 Jan;23(1):17-56

Western University, London, ON, Canada.

In this article we study the application of nonlinear indices (sometimes called complexity indices) to univariate time series data arising from studies of schizophrenia and bipolar disorder. Specifically, we consider time series arising from EEG studies, ECG studies, and self-report mood data. As part of our analysis, we empirically examine the claim in the literature that complexity tends to be higher in the EEG of schizophrenia patients than controls and that this tendency is dampened or even inverted by medication, increasing age, and reduced symptomatology. Read More

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January 2019

A Decade of Improvement in Door-to-Needle Time Among Acute Ischemic Stroke Patients, 2008 to 2017.

Circ Cardiovasc Qual Outcomes 2018 Dec;11(12):e004981

Division for Heart Disease and Stroke Prevention, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA (X.T., J.L.W., M.G.G., E.C.O., S.M.C.K., T.C., X.Y., R.K.M.).

Background: The clinical benefit of intravenous (IV) alteplase in acute ischemic stroke is time dependent. We assessed the overall temporal changes in door-to-needle (DTN) time and examine the factors associated with DTN time ≤60 and ≤45 minutes.

Methods And Results: A total of 496 336 acute ischemic stroke admissions were identified in the Paul Coverdell National Acute Stroke Program from 2008 to 2017. Read More

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December 2018

Preoperative β-Blockers for Isolated Coronary Artery Bypass Graft.

Circ Cardiovasc Qual Outcomes 2018 Dec;11(12):e005027

Department of Cardiothoracic Surgery, The Heart Hospital Baylor Plano, TX (J.R.E.).

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December 2018

Dysregulation of insulin levels in Chagas' heart disease is associated with altered adipocytokine levels.

Can J Physiol Pharmacol 2018 Dec 17. Epub 2018 Dec 17.

Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Cardiomyopathy, São Paulo, Brazil ;

Metabolic, inflammatory, and autonomic nervous system dysfunction are present in patients with heart failure. However, whether these changes are due to left ventricular dysfunction or heart failure etiology is unknown. We evaluated metabolism and inflammatory activity in patients with idiopathic dilated cardiomyopathy (IDC) and chagasic cardiomyopathy (CHG) and their correlation with the autonomic nervous system (ANS). Read More

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December 2018

GBP1 exerts inhibitory effects on acute viral myocarditis through the inhibition of inflammatory response of macrophage in mice.

Biochem Cell Biol 2018 Dec 17. Epub 2018 Dec 17.

China-Japan Union Hospital of Jilin University, 74569, Cardiology , No. 126, Xiantai Street , Changchun, China , 130031 ;

Viral myocarditis (VMC) is a condition that could potentially progress to dilated cardiomyopathy or congestive heart failure, making it the leading cause of the untimely death in young adults. Interferon-induced GBP1 encodes much GTPase induced by interferon gamma in many eukaryotic cells. However, there is little known regarding the effect of GBP1 on acute VMC (AVMC). Read More

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December 2018

Efficacy and safety of dronedarone in patients with amiodarone-induced hyperthyroidism: a clinical study.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8502-8508

Division of Cardiology, University of Rome Tor Vergata, Rome, Italy.

Objective: The aim of the study was to examine the safety and efficacy of dronedarone in patients with a history of atrial fibrillation and amiodarone-induced hyperthyroidism.

Patients And Methods: We conducted a prospective study to evaluate the use of amiodarone and dronedarone in 124 patients with a history of paroxysmal atrial fibrillation who had no additional structural heart disease. All patients received amiodarone 200 mg qd. Read More

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December 2018

Overexpression of miR-638 attenuated the effects of hypoxia/reoxygenation treatment on cell viability, cell apoptosis and autophagy by targeting ATG5 in the human cardiomyocytes.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8462-8471

Clinical Research Center, The Second Clinical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China.

Objective: Myocardial ischemia/reperfusion (I/R) injury largely contributed to the damage of myocardial tissues in patients with coronary disease, which may subsequently lead to heart failure. MicroRNAs (miRNAs) are considered to be involved in the process of myocardial I/R injury. The present study aimed to investigate the in vitro functional role of miR-638 in the myocardial I/R injury in the human cardiomyocytes (HCMs). Read More

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December 2018

miRNA-130a improves cardiac function by down-regulating TNF-α expression in a rat model of heart failure.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8454-8461

Department of Cardiovascular Medicine, The First College of Clinical Medical Science, Three Gorges University, China; Yichang Central People's Hospital, Yichang City, Hubei Province, China.

Objective: To investigate the effect of MicroRNA (miRNA)-130a on cardiac function and the expression of tumor necrosis factor-α (TNF-α) in rats with heart failure.

Materials And Methods: The rat heart failure model (n = 30) were established, then divided into miRNA-130a group, phosphate-buffer saline (PBS) group, rAAV9 group, and sham group (n = 10 in each group). Four weeks after the operation, the cardiac ultrasound and hemodynamic determination were performed. Read More

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December 2018

Tolerance of Rib Raising Among Hospitalized Patients: A Pilot Study.

J Am Osteopath Assoc 2018 Dec 17. Epub 2018 Dec 17.

Context: Rib raising is an osteopathic manipulative treatment modality that can help patients with various respiratory conditions to improve their work of breathing. However, the tolerance of this technique in hospitalized patients has not been assessed in a systematic manner. We hypothesized that rib raising would be a well-tolerated treatment modality for hospitalized patients admitted for asthma, pneumonia, chronic obstructive pulmonary disease, and/or congestive heart failure. Read More

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December 2018

Temporal Trends in Unstable Angina Diagnosis Codes for Outpatient Percutaneous Coronary Interventions.

JAMA Intern Med 2018 Dec 17. Epub 2018 Dec 17.

Richard and Susan Smith Center for Outcomes Research in Cardiology, Division of Cardiology, Beth Israel Deaconess Medical and Harvard Medical School, Boston, Massachusetts.

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December 2018

Reuse of catheters and devices labelled for single use: evidence, recommendations and oversight.

Heart Asia 2018 9;10(2):e011033. Epub 2018 Nov 9.

Department of Internal Medicine, Division of Cardiovascular Disease, The University of Michigan, Ann Arbor, Michigan, USA.

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November 2018
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VNUT and VMAT2 segregate within sympathetic varicosities and localize near preferred Cav2 isoforms in the rat tail artery.

Am J Physiol Heart Circ Physiol 2019 Jan 12;316(1):H89-H105. Epub 2018 Oct 12.

Department of Biomedical Physiology and Kinesiology, Simon Fraser University , Burnaby, British Columbia , Canada.

ATP and norepinephrine (NE) are coreleased from peripheral sympathetic nerve terminals. Whether they are stored in the same vesicles has been debated for decades. Preferential dependence of NE or ATP release on Ca influx through specific voltage-gated Ca channel (Cav2) isoforms suggests that NE and ATP are stored in separate vesicle pools, but simultaneous imaging of NE and ATP containing vesicles within single varicosities has not been reported. Read More

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January 2019
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Elevated arterial shear rate increases indexes of endothelial cell autophagy and nitric oxide synthase activation in humans.

Am J Physiol Heart Circ Physiol 2019 Jan 9;316(1):H106-H112. Epub 2018 Nov 9.

Department of Nutrition and Integrative Physiology, University of Utah , Salt Lake City, Utah.

Continuous laminar shear stress increases the process of autophagy, activates endothelial nitric oxide (NO) synthase phosphorylation at serine 1177 (p-eNOS), and generates NO in bovine and human arterial endothelial cells (ECs) compared with static controls. However, the translational relevance of these findings has not been explored. In the current study, primary ECs were collected from the radial artery of 7 men using sterile J-wires before (Pre) and after (Post) 60 min of rhythmic handgrip exercise (HG) performed with the same arm. Read More

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January 2019

RNA processing in skeletal muscle biology and disease.

Transcription 2018 Dec 17. Epub 2018 Dec 17.

a Curriculum in Genetics and Molecular Biology (GMB) , University of North Carolina at Chapel Hill , USA.

RNA processing encompasses the capping, cleavage, polyadenylation and alternative splicing of pre-mRNA. Proper muscle development relies on precise RNA processing, driven by the coordination between RNA-binding proteins. Recently, skeletal muscle biology has been intensely investigated in terms of RNA processing. Read More

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December 2018

Comparing anxiety and depression to obesity and smoking as predictors of major medical illnesses and somatic symptoms.

Health Psychol 2018 Dec 17. Epub 2018 Dec 17.

San Francisco VA Medical Center.

Objective: Anxiety and depression predict poor physical health longitudinally, but are neglected in primary care settings compared to other risk factors such as obesity and smoking. Further, anxiety has been less commonly studied than depression, and whether anxiety has unique predictive effects for physical health is unknown. We compared anxiety and depression to obesity and smoking as predictors of physical health indices and examined unique predictive effects of anxiety and depression. Read More

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December 2018

Decision making in response to physiological and combined physiological and psychosocial stress.

Behav Neurosci 2018 Dec 17. Epub 2018 Dec 17.

Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin.

Individuals tend to make riskier decisions in response to stress. The magnitude of the stress effect on decision-making under risk seems to depend on the stressor type and the decision situation. We examined the effects of physiological and combined physiological and psychosocial stress on decision-making under risk and whether risk taking differs between women and men. Read More

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December 2018

Ellis-Van Creveld Syndrome and Dandy-Walker Malformation: An Uncommon Association.

Pediatr Endocrinol Rev 2018 Dec;16(2):275-283

Medical School, Mohammed VI Hospital 4806, 60049 Oujda, Morocco, E-mail:

Ellis-Van Creveld (EvC) syndrome is a rare autosomal recessive chondroectodermal dysplasia including chondrodysplasia, postaxial polydactyly, ectodermal dysplasia, and congenital heart disease in 60% of patients. Additional findings may be observed affecting the pulmonary, renal, gastrointestinal, hematologic, and central nervous systems. We report a case of an 11-year-old Moroccan boy with EVC syndrome and Dandy-Walker malformation. Read More

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December 2018

A multicentered evaluation of ablation at higher power guided by ablation index: establishing ablation targets for pulmonary vein isolation.

J Cardiovasc Electrophysiol 2018 Dec 16. Epub 2018 Dec 16.

Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom.

Background: Pulmonary vein isolation (PVI) using high power delivered by surround flow (STSF) catheters guided by ablation index (AI) was evaluated in a multicenter registry.

Methods: Patients with paroxysmal AF underwent PVI with STSF catheters using 30W on the posterior wall and 40W elsewhere. AI targets were 350 posterior wall and 450 elsewhere. Read More

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December 2018
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