35,840 results match your criteria Healthy Aging & Clinical Care in the Elderly [Journal]


Age-Related Alterations in Retinal Tissue Perfusion and Volumetric Vessel Density.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):685-693

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.

Purpose: To determine age-related alterations in the retinal tissue perfusion (RTP) and volumetric vessel density (VVD) in healthy subjects.

Methods: Total 148 healthy subjects (age 18 to 83 years) were enrolled and divided into four groups (G1, <35 years; G2, 35 ∼ 49 years; G3, 50 ∼ 64 years; and G4, ≥65 years). The RTP and VVD were measured at the macula. Read More

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http://dx.doi.org/10.1167/iovs.18-25864DOI Listing
February 2019

Inhibition of the amino-acid transporter LAT1 demonstrates anti-neoplastic activity in medulloblastoma.

J Cell Mol Med 2019 Feb 19. Epub 2019 Feb 19.

Biomedical Department, Centre Scientifique de Monaco, Monaco, Principality of Monaco.

Most cases of medulloblastoma (MB) occur in young children. While the overall survival rate can be relatively high, current treatments combining surgery, chemo- and radiotherapy are very destructive for patient development and quality of life. Moreover, aggressive forms and recurrences of MB cannot be controlled by classical therapies. Read More

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http://dx.doi.org/10.1111/jcmm.14176DOI Listing
February 2019

Comorbidity of reading disabilities and ADHD: Structural and functional brain characteristics.

Hum Brain Mapp 2019 Feb 19. Epub 2019 Feb 19.

Laboratories of Cognitive Neuroscience, Division of Developmental Medicine, Department of Medicine, Boston Children's Hospital, Boston, Massachusetts.

Reading disabilities (RD) and attention-deficit/hyperactivity disorder (ADHD) are two of the most common developmental disorders. RD and ADHD frequently co-occur, which raises questions about how the disorders interact and to what extent they can be differentiated. To date, the underlying neural mechanisms leading to RD-ADHD comorbidity (COM) are not understood. Read More

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http://dx.doi.org/10.1002/hbm.24552DOI Listing
February 2019

Single finger movements in the aging hand: changes in finger independence, muscle activation patterns and tendon displacement in older adults.

Exp Brain Res 2019 Feb 19. Epub 2019 Feb 19.

Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

With aging, hand mobility and manual dexterity decline, even under healthy circumstances. To assess how aging affects finger movement control, we compared elderly and young subjects with respect to (1) finger movement independence, (2) neural control of extrinsic finger muscles and (3) finger tendon displacements during single finger flexion. In twelve healthy older (age 68-84) and nine young (age 22-29) subjects, finger kinematics were measured to assess finger movement enslaving and the range of independent finger movement. Read More

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http://dx.doi.org/10.1007/s00221-019-05487-1DOI Listing
February 2019

Serum 25-Hydroxy Vitamin D in Chronic Rhinosinusitis with and Without Nasal Polyposis: A Case-Control Study.

Iran J Otorhinolaryngol 2019 Jan;31(102):19-24

Rhino-Sinus, Ear, and Skull base Diseases Research Center, Department of Otolaryngology and Head and Neck Surgury, Amiralmomenin Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

Introduction: Chronic rhinosinusitis (CRS) with and without nasal polyposis is a chronic inflammatory disease of the sinuses and nasal mucosa. Recent evidence has indicated a relationship between serum 25-hydroxyl vitamin D (OH-VitD) deficiency and CRS. Regarding this, the present study aimed to compare the serum level of 25-OH-VitD in CRS patients with and without nasal polyposis and control groups. Read More

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January 2019

Scalp Condition Impacts Hair Growth and Retention via Oxidative Stress.

Int J Trichology 2018 Nov-Dec;10(6):262-270

Sharon Woods Innovation Center, Cincinnati, OH, USA.

Conventionally, the medical focus has been either on hair loss or the condition of the scalp in terms of specific dermatological diseases. Indeed, the proximate structural arrangement of the scalp and hair leads to an interdependent relationship between the two. While protective benefits of the hair to the scalp are obvious, the role of the scalp as an incubatory environment for the preemergent hair fiber has largely been ignored. Read More

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http://dx.doi.org/10.4103/ijt.ijt_57_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369642PMC
February 2019

Comparison of Kinect2Scratch game-based training and therapist-based training for the improvement of upper extremity functions of patients with chronic stroke: a randomized controlled single-blinded trial.

Eur J Phys Rehabil Med 2019 Feb 15. Epub 2019 Feb 15.

SMARTlab, University College Dublin, Belfield, Dublin 4, Ireland.

Background: Virtual reality and interactive video games could decrease the demands on the time of the therapists. However, the cost of a virtual reality system and the requirement for technical support limits the availability of these systems. Commercial exergames are not specifically designed for therapeutic use, most patients with hemiplegic stroke are either too weak to play the games or develop undesirable compensatory movements. Read More

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http://dx.doi.org/10.23736/S1973-9087.19.05598-9DOI Listing
February 2019

Osteogenic Dkk1 mediates glucocorticoid-induced, but not arthritis-induced bone loss.

J Bone Miner Res 2019 Feb 19. Epub 2019 Feb 19.

Department of Medicine III, Technische Universität Dresden, Dresden, Germany.

Dickkopf-1 (Dkk1) is a negative regulator of bone formation and bone mass and is deregulated in bone loss induced by arthritis and glucocorticoid (GC) exposure. However, the role of Dkk1 in these pathological processes is still unknown. Here, we used conditional Dkk1 knock-out mice to determine the role of Dkk1 produced by osteolineage cells in the development of arthritis and GC-induced bone loss. Read More

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http://doi.wiley.com/10.1002/jbmr.3702
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http://dx.doi.org/10.1002/jbmr.3702DOI Listing
February 2019
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Age and poverty status alter the coding and noncoding transcriptome.

Aging (Albany NY) 2019 Feb 17. Epub 2019 Feb 17.

Laboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

Emerging evidence indicates that noncoding RNAs play regulatory roles in aging and disease. The functional roles of long noncoding RNAs (lncRNAs) in physiology and disease are not completely understood. Little is known about lncRNAs in the context of human aging and socio-environmental conditions. Read More

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http://dx.doi.org/10.18632/aging.101823DOI Listing
February 2019

Toxicity of blue led light and A2E is associated to mitochondrial dynamics impairment in ARPE-19 cells: implications for age-related macular degeneration.

Arch Toxicol 2019 Feb 18. Epub 2019 Feb 18.

Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Instituto de Química Biológica Ciencias Exactas y Naturales (IQUIBICEN), CONICET-Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, 1428, Buenos Aires, Argentina.

Age-related macular degeneration (AMD) is a multifactorial retinal disease characterized by a progressive loss of central vision. Retinal pigment epithelium (RPE) degeneration is a critical event in AMD. It has been associated to A2E accumulation, which sensitizes RPE to blue light photodamage. Read More

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http://dx.doi.org/10.1007/s00204-019-02409-6DOI Listing
February 2019

Parent-Adult Child Relations of Chinese Older Immigrants in the United States: Is There an Optimal Type?

J Gerontol B Psychol Sci Soc Sci 2019 Feb 18. Epub 2019 Feb 18.

Rutgers University, Institute for Health, Health Care Policy and Aging Research, New Brunswick, New Jersey.

Objectives: This study aims to identify 1) different types of parent-child relations among Chinese older immigrants, 2) predictors of each relation type, and 3) the most "optimal" type that is associated with better psychological well-being of the older adults.

Methods: Data were derived from 3,109 Chinese elderly in Chicago. Latent Class Analysis was used to identify structures of parent-child relations based on eight indicators of family solidarity. Read More

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http://dx.doi.org/10.1093/geronb/gbz021DOI Listing
February 2019

Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology.

Mol Psychiatry 2019 Feb 18. Epub 2019 Feb 18.

Melbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Vic, Australia.

Cortical iron has been shown to be elevated in Alzheimer's disease (AD), but the impact of the directly measured iron on the clinical syndrome has not been assessed. We investigated the association between post-mortem iron levels with the clinical and pathological diagnosis of AD, its severity, and the rate of cognitive decline in the 12 years prior to death in subjects from the Memory and Aging Project (n = 209). Iron was elevated (β [SE] = 9. Read More

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http://dx.doi.org/10.1038/s41380-019-0375-7DOI Listing
February 2019

Noninvasive prediction of Blood Lactate through a machine learning-based approach.

Sci Rep 2019 Feb 18;9(1):2180. Epub 2019 Feb 18.

Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.

We hypothesized that blood lactate concentration([Lac]) is a function of cardiopulmonary variables, exercise intensity and some anthropometric elements during aerobic exercise. This investigation aimed to establish a mathematical model to estimate [Lac] noninvasively during constant work rate (CWR) exercise of various intensities. 31 healthy participants were recruited and each underwent 4 cardiopulmonary exercise tests: one incremental and three CWR tests (low: 35% of peak work rate for 15 min, moderate: 60% 10 min and high: 90% 4 min). Read More

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http://dx.doi.org/10.1038/s41598-019-38698-1DOI Listing
February 2019

Beyond episodic memory: Semantic processing as independent predictor of hippocampal/perirhinal volume in aging and mild cognitive impairment due to Alzheimer's disease.

Neuropsychology 2019 Feb 18. Epub 2019 Feb 18.

Department of Neuroscience, University of Sheffield.

Objective: Given that lexical-semantic decline precedes episodic memory deficits in the Alzheimer's disease (AD) timeline, it is expected that performance on a lexical-semantic task would be associated with mediotemporal volumes independently of the association this region has with episodic memory in the early stage of AD.

Method: Fifty patients with mild cognitive impairment due to AD and 50 healthy adults completed tests of lexical-semantic skills (category fluency test), episodic memory for semantically relevant material (prose memory test), episodic memory for non semantically relevant material (Rey-Osterrieth Figure test), lexical-executive abilities (letter fluency test), and a neurostructural MRI. Hippocampal, perirhinal, entorhinal, temporopolar, and orbitofrontal volumes were extracted. Read More

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http://dx.doi.org/10.1037/neu0000534DOI Listing
February 2019

Importance of medical data preprocessing in predictive modeling and risk factor discovery for the frailty syndrome.

BMC Med Inform Decis Mak 2019 Feb 18;19(1):33. Epub 2019 Feb 18.

Holzinger Group, HCI-KDD, Institute for Medical Informatics/Statistics, Medical University Graz, Graz, 8036, Austria.

Background: Increasing life expectancy results in more elderly people struggling with age related diseases and functional conditions. This poses huge challenges towards establishing new approaches for maintaining health at a higher age. An important aspect for age related deterioration of the general patient condition is frailty. Read More

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http://dx.doi.org/10.1186/s12911-019-0747-6DOI Listing
February 2019

Favorable effects of skeletal muscle on bone are distinguished according to gender and skeletal sites.

Osteoporos Sarcopenia 2017 Mar 7;3(1):32-36. Epub 2016 Dec 7.

Division of Geriatrics, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.

Objectives: The aim of this study was to investigate associations between skeletal muscle mass and bone mineral density according to gender and skeletal sites.

Methods: Using the data from Korean National Health and Nutrition Examination Survey (KNHANES IV) 2009, a total of 711 males and 847 females over 65 years of age were evaluated. Bone mineral density (BMD) and body composition were assessed using dual-energy X-ray absorptiometry. Read More

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http://dx.doi.org/10.1016/j.afos.2016.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372766PMC

Psychometric liability to psychosis and childhood adversities are associated with shorter telomere length: A study on schizophrenia patients, unaffected siblings, and non-clinical controls.

J Psychiatr Res 2019 Feb 8;111:169-185. Epub 2019 Feb 8.

Brain Research Center, Ankara University, Ankara, Turkey. Electronic address:

Compared to the general population, individuals diagnosed with Schizophrenia (SCZ) experience a higher frequency and an earlier onset of chronic medical disorders, resulting in a reduction in life expectancy by an average of 15-25 years. Recently, it has been hypothesized that SCZ is a syndrome of accelerated aging. Childhood adversity was also associated with the pathogenesis and course of SCZ. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.022DOI Listing
February 2019

Cerebrovascular disease burden in late-onset non-lesional focal epilepsy.

Seizure 2019 Feb 8;66:31-35. Epub 2019 Feb 8.

Epilepsy Unit, Neurology Department, Vall d'Hebron University Hospital, Autonomous University of Barcelona, Barcelona, Spain. Electronic address:

Purpose: Late-onset non-lesional focal epilepsy, defined as new-onset seizures in patients older than 60 years, is diagnosed increasingly more often in relation to aging of the population. It has been attributed mainly to occult cerebral small vessel disease (SVD), although high levels of evidence to support this notion are lacking. This study aimed to evaluate the burden of leukoaraiosis, a marker of cerebral SVD, and hippocampal atrophy in patients with late-onset epilepsy (LOE). Read More

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http://dx.doi.org/10.1016/j.seizure.2019.02.004DOI Listing
February 2019

Assessment of perimenopausal depression: A review.

J Affect Disord 2019 Feb 11;249:216-222. Epub 2019 Feb 11.

Clinical Psychology and Psychotherapy, University of Zurich, Binzmühlestrasse 14, Zurich 8050, Switzerland; URPP Dynamics of Healthy Aging Research Priority Program, University of Zurich, Zurich, Switzerland. Electronic address:

Background: Within the female life cycle, the perimenopause is considered as a critical period for the development of depression. Prevalence rates are particularly high during this phase. Perimenopausal depression is characterized by affective symptoms as well as menopause-specific somatic complaints. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.029DOI Listing
February 2019

Age-related differences in neural spectral power during motor learning.

Neurobiol Aging 2019 Jan 6;77:44-57. Epub 2019 Jan 6.

KU Leuven, Department of Movement Sciences, Movement Control and Neuroplasticity Research Group, Leuven, Belgium; KU Leuven, Leuven Brain Institute (LBI), Leuven, Belgium.

We investigated how older adults preserve the capability to acquire new motor skills in the face of age-related brain alterations. We assessed neural changes associated with learning a bimanual coordination task over 4 days of practice in healthy young (n = 24) and older adults (n = 24). The electroencephalogram was recorded during task performance at the start and end of training. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.12.013DOI Listing
January 2019

Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study.

Neurobiol Aging 2019 Jan 26;77:37-43. Epub 2019 Jan 26.

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands. Electronic address:

There is ample evidence that phosphodiesterase 4 (PDE4) inhibition can improve memory performance in animal studies. In the present study, we examined the acute effects of the PDE4 inhibitor roflumilast on memory performance in healthy individuals (60-80 years of age). We tested the effects of acute roflumilast administration (100, 250, 1000 μg) in a double-blind, placebo-controlled, 4-way crossover design. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.01.014DOI Listing
January 2019

Frailty and health risks in an agricultural population, Chile 2014-2017.

Arch Gerontol Geriatr 2019 Feb 10;82:114-119. Epub 2019 Feb 10.

Advanced Center for Chronic Diseases (ACCDiS), Pontificia Universidad Católica de Chile, Diagonal Paraguay 362, Santiago, Chile; Public Health Department, School of Medicine, Pontificia Universidad Católica de Chile, Diagonal Paraguay 362, Santiago, Chile. Electronic address:

Background: Aging presents an emerging health and social challenge. We report the prevalence of frailty, its association with chronic diseases and the risk of hospitalization or death within 29 months.

Methods: Cross-sectional and prospective study. Read More

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http://dx.doi.org/10.1016/j.archger.2019.01.012DOI Listing
February 2019

Midlife Long-Hour Working and Later-life Social Engagement Are Associated with Reduced Risks of Mild Cognitive Impairment among Community-Living Singapore Elderly.

J Alzheimers Dis 2019 ;67(3):1067-1077

The Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, School of Public Health, Guangxi Medical University, Nanning, Guangxi Province, China.

Mild cognitive impairment (MCI), as a transitional stage between normal aging and dementia, causes cognitive decline among one-fifth of elders aged 65 years and older. Health-related lifestyles (HRL) are generally regarded as modifiable influencing factors of cognitive decline. The present study investigated how HRLs at two different life stages (one at midlife and the other at later life) affect MCI occurrence among community-dwelling elders, as part of the Diet and Healthy Aging (DaHA) study in Singapore. Read More

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http://dx.doi.org/10.3233/JAD-180605DOI Listing
January 2019

White Matter Hyperintensities in Alzheimer's Disease: A Lesion Probability Mapping Study.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, Medical University of Graz, Graz, Austria.

Background/objective: Higher white matter hyperintensity (WMH) load has been reported in Alzheimer's disease (AD) patients in different brain regions when compared to controls. We aimed to assess possible differences of WMH spatial distribution between AD patients and age-matched controls by means of lesion probability maps.

Methods: The present study included MRI scans of 130 probable AD patients with a mean age of 73. Read More

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http://dx.doi.org/10.3233/JAD-180982DOI Listing
February 2019
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The Association between Mushroom Consumption and Mild Cognitive Impairment: A Community-Based Cross-Sectional Study in Singapore.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

We examined the cross-sectional association between mushroom intake and mild cognitive impairment (MCI) using data from 663 participants aged 60 and above from the Diet and Healthy Aging (DaHA) study in Singapore. Compared with participants who consumed mushrooms less than once per week, participants who consumed mushrooms >2 portions per week had reduced odds of having MCI (odds ratio = 0.43, 95% CI 0. Read More

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http://dx.doi.org/10.3233/JAD-180959DOI Listing
February 2019

Modifiable Risk Factors Discriminate Memory Trajectories in Non-Demented Aging: Precision Factors and Targets for Promoting Healthier Brain Aging and Preventing Dementia?

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Department of Psychology, University of Alberta, Edmonton, AB, Canada.

Background: Non-demented cognitive aging trajectories are characterized by vast level and slope differences and a spectrum of outcomes, including dementia.

Objective: The goal of AD risk management (and its corollary, promoting healthy brain aging) is aided by two converging objectives: 1) classifying dynamic distributions of non-demented cognitive trajectories, and 2) identifying modifiable risk-elevating and risk-reducing factors that discriminate stable or normal trajectory patterns from declining or pre-impairment patterns.

Method: Using latent class growth analysis we classified three episodic memory aging trajectories for n = 882 older adults (baseline Mage=71. Read More

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http://dx.doi.org/10.3233/JAD-180571DOI Listing
February 2019

Pulse wave velocity and its gender-related associations with cardiovascular risk factors in a high cardiovascular risk population.

Arch Med Sci Atheroscler Dis 2018 3;3:e99-e105. Epub 2018 Jul 3.

Department of Health Technologies, Tallinn University of Technology, Tallinn, Estonia.

Introduction: Associations found between pulse wave velocity (PWV) and cardiovascular risk factors (CVrF) are diverse. We aimed to evaluate whether differences in PWV and its associations with CVrF in a high cardiovascular risk population exist between genders and between the whole population (WHgr) and groups of apparently healthy (AHgr) and those of hypertensive, obese or diabetics (Rgr).

Material And Methods: Pulse wave velocity measured by Arteriograph was investigated in 805 adults aged 20-65, randomly selected from the Tallinn Population Register. Read More

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http://dx.doi.org/10.5114/amsad.2018.76919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374584PMC

Locomotive syndrome in Japan.

Osteoporos Sarcopenia 2018 Sep 27;4(3):86-94. Epub 2018 Sep 27.

Department of Orthopedic Surgery, Ina Hospital, 1419 Komuro, Kita-Adachi Ina, Saitama, 362-0608, Japan.

The present aging rate in Japan of some 28% will continue to increase along with the advancing age of elderly persons. Therefore, the demand for care will also increase. Approximately 25% of the need for nursing-care defined by the Japanese long-term care insurance system is associated with disorders or deterioration of locomotive organs. Read More

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http://dx.doi.org/10.1016/j.afos.2018.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362958PMC
September 2018
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ROLE of IGF-1 System in the Modulation of Longevity: Controversies and New Insights From a Centenarians' Perspective.

Front Endocrinol (Lausanne) 2019 1;10:27. Epub 2019 Feb 1.

Division Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands.

Human aging is currently defined as a physiological decline of biological functions in the body with a continual adaptation to internal and external damaging. The endocrine system plays a major role in orchestrating cellular interactions, metabolism, growth, and aging. Several studies from worms to mice showed that downregulated activity of the GH/IGF-1/insulin pathway could be beneficial for the extension of human life span, whereas results are contradictory in humans. Read More

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http://dx.doi.org/10.3389/fendo.2019.00027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367275PMC
February 2019

Exercise and Arterial Modulation in Children: The EXAMIN YOUTH Study.

Front Physiol 2019 1;10:43. Epub 2019 Feb 1.

Department of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel, Switzerland.

Cardiovascular disease (CVD) remains to be one of the most frequent causes of death worldwide. Cardiovascular (CV) risk factors such as hypertension and obesity often manifest in childhood. The study examines the associations of blood pressure, body mass index and physical activity with cardiopulmonary, metabolic, and psychosocial health of children in a systems physiology approach. Read More

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http://dx.doi.org/10.3389/fphys.2019.00043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367232PMC
February 2019

Effects of a Nintendo Wii exercise program versus Tai Chi Chuan on standing balance in older adults: a preliminary study.

J Phys Ther Sci 2019 Jan 10;31(1):1-4. Epub 2019 Jan 10.

Centre of Clinical Research Excellence in Spinal Pain, Injury and Health, School of Health and Rehabilitation Sciences, The University of Queensland, Australia.

[Purpose] This study compared the effect of the Nintendo Wii balance board (NWBB) and Tai Chi Chuan (TCC) on the standing balance (SB) of older adults. [Participants and Methods] Twelve older adults (NWBB=7 and TCC=5) completed the intervention and two testing sessions (pre-post). SB was assessed using posturographic measures with the center of pressure (CoP) in five modes: quiet eyes open (QSB-EO) and eyes closed (QSB-EC), on sponge (SBS-EO and SBS-EC), and with optokinetic field (SB-OF). Read More

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http://dx.doi.org/10.1589/jpts.31.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348192PMC
January 2019

DAF-16 stabilizes the aging transcriptome and is activated in mid-aged Caenorhabditis elegans to cope with internal stress.

Aging Cell 2019 Feb 17:e12896. Epub 2019 Feb 17.

National Institute of Biological Sciences, Beijing, China.

The roles and regulatory mechanisms of transcriptome changes during aging are unclear. It has been proposed that the transcriptome suffers decay during aging owing to age-associated down-regulation of transcription factors. In this study, we characterized the role of a transcription factor DAF-16, which is a highly conserved lifespan regulator, in the normal aging process of Caenorhabditis elegans. Read More

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http://dx.doi.org/10.1111/acel.12896DOI Listing
February 2019

[The relationship between simple numerical function and gray matter volume in normal brain aging].

Zhonghua Yi Xue Za Zhi 2019 Jan;99(5):370-374

Department of MRI, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To explore the relationship between simple numerical function and gray matter volume (GMV) in normal brain aging using the voxel-based morphometry(VBM) approach. A total of 123 individuals from 18 to 70 years old (63 males,60 females,the average age was (43±14) years, were recruited from right-handed healthy Han Chinese volunteers at the Department of MRI at the First Affiliated Hospital of Zhengzhou University between October 2016 and June 2017. All subjects underwent magnetic resonance sagital three-dimensional imaging scanning, and statistical parameter graph (SPM) 8 software was used for voxel-based morphological analysis to compare the differences in gray matter volume between different age groups. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.05.010DOI Listing
January 2019

Risk factors and self-perception for facial aging among Nepalese population.

J Cosmet Dermatol 2019 Feb 17. Epub 2019 Feb 17.

Department of Dermatology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal.

Background: Facial appearance has increasing importance to individuals and women, in particular. Till date, there are no reports of the extrinsic factors influencing skin aging in Nepalese population.

Objectives: To assess the risk factors and self-perception for facial aging in Nepalese population. Read More

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http://dx.doi.org/10.1111/jocd.12885DOI Listing
February 2019

Update on the impact of type 2 diabetes mellitus on bone metabolism and material properties.

Endocr Connect 2019 Mar;8(3):R55-R70

Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany.

The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide, especially as a result of our aging society, high caloric intake and sedentary lifestyle. Besides the well-known complications of T2DM on the cardiovascular system, the eyes, kidneys and nerves, bone strength is also impaired in diabetic patients. Patients with T2DM have a 40-70% increased risk for fractures, despite having a normal to increased bone mineral density, suggesting that other factors besides bone quantity must account for increased bone fragility. Read More

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http://dx.doi.org/10.1530/EC-18-0456DOI Listing
March 2019
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Event-related potentials associated with auditory attention capture in younger and older adults.

Neurobiol Aging 2019 Jan 24;77:20-25. Epub 2019 Jan 24.

School of Psychology, University of Ottawa, Ottawa, Canada; Bruyère Research Institute, Ottawa, Canada. Electronic address:

A deviant-related negativity (DRN), mismatch negativity (MMN), and P3a are electrophysiological measures thought to reflect processes involved in the involuntary switching of attention to a task-irrelevant stimulus. The purpose of this article was to determine whether healthy older adults involuntarily detect unattended auditory stimuli as efficiently as younger adults. To test this, 20 younger adults (aged 18-30 years) and 20 older adults (aged 65+ years) were presented with to-be-ignored auditory sequences consisting of frequently presented 80 dB SPL standards and rarely presented increments (+10 dB) and decrements (-20 dB). Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.01.012DOI Listing
January 2019

"Looks familiar, but I do not know who she is": The role of the anterior right temporal lobe in famous face recognition.

Cortex 2019 Jan 23;115:72-85. Epub 2019 Jan 23.

Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA, USA; Department of Neurology, Dyslexia Center, University of California, San Francisco, CA, USA.

Processing a famous face involves a cascade of steps including detecting the presence of a face, recognizing it as familiar, accessing semantic/biographical information about the person, and finally, if required, production of the proper name. Decades of neuropsychological and neuroimaging studies have identified a network of occipital and temporal brain regions ostensibly comprising the 'core' system for face processing. Recent research has also begun to elucidate upon an 'extended' network, including anterior temporal and frontal regions. Read More

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http://dx.doi.org/10.1016/j.cortex.2019.01.006DOI Listing
January 2019
2 Reads

Putting participants at the centre of HIV cure research.

Lancet HIV 2019 Feb 13. Epub 2019 Feb 13.

Collaboratory of AIDS Researchers for Eradication Community Advisory Board, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; HIV and Aging Research Project-Palm Springs, CA, USA.

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http://dx.doi.org/10.1016/S2352-3018(19)30031-1DOI Listing
February 2019

Clusters of non-adherence to medication in neurological patients.

Res Social Adm Pharm 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, Jena University Hospital, Jena, Germany.

Background: Non-adherence to medication is a common and serious problem in health care. To develop more effective interventions to improve adherence, there is a need for a better understanding of the individual types of non-adherence.

Objective: To determine clusters of non-adherence in neurological patients using a complex adherence questionnaire. Read More

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http://dx.doi.org/10.1016/j.sapharm.2019.01.001DOI Listing
February 2019

Arriba por la vida Estudio (AVE): Study protocol for a standing intervention targeting postmenopausal Latinas.

Contemp Clin Trials 2019 Feb 13. Epub 2019 Feb 13.

University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States.

Background: Postmenopausal Latinas are a growing population group in the US who are at high risk for cardiovascular disease. Epidemiological studies have shown that excessive sitting is related to cardiovascular disease risk. Older women sit for prolonged periods and most individuals do not meet physical activity guidelines. Read More

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http://dx.doi.org/10.1016/j.cct.2019.02.004DOI Listing
February 2019
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Pattern of Cerebellar Atrophy in Friedreich's Ataxia-Using the SUIT Template.

Cerebellum 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurology and Hertie Institute for Clinical Brain Research, Eberhard Karls University, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.

Whole-brain voxel-based morphometry (VBM) studies revealed patterns of patchy atrophy within the cerebellum of Friedreich's ataxia patients, missing clear clinico-anatomic correlations. Studies so far are lacking an appropriate registration to the infratentorial space. To circumvent these limitations, we applied a high-resolution atlas template of the human cerebellum and brainstem (SUIT template) to characterize regional cerebellar atrophy in Friedreich's ataxia (FRDA) on 3-T MRI data. Read More

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http://dx.doi.org/10.1007/s12311-019-1008-zDOI Listing
February 2019

Improvements cardiometabolic risk factors in Latin American Amerindians (the Mapuche) with concurrent training.

Scand J Med Sci Sports 2019 Feb 15. Epub 2019 Feb 15.

Education department of La Unión city, Chile.

Our aim was to investigate the effects of 12-weeks of CT (i.e., high-intensity interval and resistance training) in Mapuche adults from Chile and in their peers of European descent. Read More

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http://dx.doi.org/10.1111/sms.13409DOI Listing
February 2019
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Supplementation with N-Acetyl Cysteine Affects Motor and Cognitive Function in Young but Not Old Mice.

J Nutr 2019 Feb 15. Epub 2019 Feb 15.

Department of Pharmacology and Neuroscience and Institute for Healthy Aging, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX.

Background: N-acetyl cysteine (NAC) is a thiolic antioxidant that is thought to increase cellular glutathione (GSH) by augmenting the concentration of available cysteine, an essential precursor to GSH production. Manipulating redox status can affect brain function, and NAC intake has been associated with improving brain function in models of neurodegenerative diseases.

Objectives: The objective of the study was to determine if short-term dietary supplementation with NAC could ameliorate functional impairment associated with aging. Read More

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http://dx.doi.org/10.1093/jn/nxy287DOI Listing
February 2019
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VisMET: a passive, efficient, and sensitive assessment of visuospatial memory in healthy aging, mild cognitive impairment, and Alzheimer's disease.

Learn Mem 2019 Mar 15;26(3):93-100. Epub 2019 Feb 15.

Department of Neurology, Emory University, Atlanta, Georgia 30312, USA.

The entorhinal-hippocampal circuit is one of the earliest sites of cortical pathology in Alzheimer's disease (AD). Visuospatial memory paradigms that are mediated by the entorhinal-hippocampal circuit may offer a means to detect memory impairment during the early stages of AD. In this study, we developed a 4-min visuospatial memory paradigm called VisMET (Visuospatial Memory Eye-Tracking Task) that passively assesses memory using eye movements rather than explicit memory judgements. Read More

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http://dx.doi.org/10.1101/lm.048124.118DOI Listing

Spatial and Temporal Mapping of Human Innate Lymphoid Cells Reveals Elements of Tissue Specificity.

Immunity 2019 Feb 12;50(2):505-519.e4. Epub 2019 Feb 12.

Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Stanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, 10021, USA. Electronic address:

Innate lymphoid cells (ILC) play critical roles in regulating immunity, inflammation, and tissue homeostasis in mice. However, limited access to non-diseased human tissues has hindered efforts to profile anatomically-distinct ILCs in humans. Through flow cytometric and transcriptional analyses of lymphoid, mucosal, and metabolic tissues from previously healthy human organ donors, here we have provided a map of human ILC heterogeneity across multiple anatomical sites. Read More

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http://dx.doi.org/10.1016/j.immuni.2019.01.012DOI Listing
February 2019

High-Intensity Interval Training Improves Erythrocyte Osmotic Deformability.

Med Sci Sports Exerc 2019 Feb 13. Epub 2019 Feb 13.

Healthy Aging Research Center, Graduate Institute of Rehabilitation Science, Medical Collage, Chang Gung University, Tao-Yuan, Taiwan.

Introduction: Physical exercise or hypoxic exposure influences erythrocyte susceptibility to osmotic stress, and the aquaporin 1 (AQP1) facilitates the transport of water in erythrocytes. This study investigated whether high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) affect erythrocyte osmotic deformability by modulating AQP1 function under hypoxic stress.

Methods: Forty-five healthy sedentary males were randomized to engage in either HIIT (3-min intervals at 40 % and 80 % VO2 reserve, n=15) or MICT (sustained 60 % VO2 reserve, n=15) on a bicycle ergometer for 30 min/day, 5 days/week for 6 weeks, or to a control group that did not perform any exercise (n=15). Read More

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http://dx.doi.org/10.1249/MSS.0000000000001923DOI Listing
February 2019

Gp49B is a pathogenic marker for autoantibody-producing plasma cells in lupus-prone BXSB/Yaa mice.

Int Immunol 2019 Feb 15. Epub 2019 Feb 15.

Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

Immune homeostasis is critically regulated by the balance between activating and inhibitory receptors expressed on various immune cells such as T and B lymphocytes, and myeloid cells. The inhibitory receptors play a fundamental role in the immune-checkpoint pathway, thus maintaining peripheral tolerance. We recently found that expression of leukocyte immunoglobulin-like receptor (LILR)B4, an inhibitory member of the human LILR family, is augmented in autoantibody-producing plasmablasts/plasma cells of systemic lupus erythematosus (SLE) patients. Read More

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http://dx.doi.org/10.1093/intimm/dxz017DOI Listing
February 2019
2.536 Impact Factor

Evaluating Mobile Health Apps for Customized Dietary Recording for Young Adults and Seniors: Randomized Controlled Trial.

JMIR Mhealth Uhealth 2019 Feb 15;7(2):e10931. Epub 2019 Feb 15.

Department of Health Care Management and Healthy Aging Research Center, College of Management, Chang Gung University, Taoyuan, Taiwan.

Background: The role of individual-tailored dietary recording in mobile phone health apps has become increasingly important in management of self-health care and population-based preventive service. The development of such mobile apps for user-centered designing is still challengeable and requires further scientific evidence.

Objective: This study aims to conduct a randomized trial to assess the accuracy and time efficiency of two prototypes for dietary recoding utilization related to the input method of food intake. Read More

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http://dx.doi.org/10.2196/10931DOI Listing
February 2019

The Daniel K. Inouye College of Pharmacy Scripts: Perspectives on the Epidemiology of Gout and Hyperuricemia.

Authors:
Youssef M Roman

Hawaii J Med Public Health 2019 Feb;78(2):71-76

Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI.

Gout is the most common inflammatory arthritic condition affecting more men than women. Hyperuricemia and the deposition of urate crystals into the joints are the hallmarks of gout. The prevalence of gout and hyperuricemia is rising in the United States and world-wide possibly due to the aging population, comorbidities, and other lifestyle factors. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369891PMC
February 2019
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Is in utero exposure to maternal socioeconomic disadvantage related to offspring ovarian reserve in adulthood?

Womens Midlife Health 2018 16;4. Epub 2018 Mar 16.

6Department of Obstetrics, Gynecology, & Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143 USA.

Background: Because the ovarian follicle pool is established in utero, adverse exposures during this period may be especially impactful on the size and health of the initial follicle endowment, potentially shaping trajectories of ovarian follicle loss and the eventual onset of menopause. Building on a robust literature linking socioeconomic status (SES) and menopausal timing, the current study examined adverse prenatal exposures related to maternal SES, hypothesizing that greater maternal socioeconomic disadvantage would be associated with lower ovarian reserve in the adult offspring.

Methods: In a healthy, community-based sub-sample ( = 350) of reproductive age participants in the OVA Study (2006-2011), prenatal maternal SES was examined in relation to two biomarkers of ovarian reserve, antimullerian hormone (AMH) and antral follicle count (AFC). Read More

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http://dx.doi.org/10.1186/s40695-018-0033-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297989PMC