36,431 results match your criteria Healthy Aging & Clinical Care in the Elderly [Journal]


Comparability of biological aging measures in the National Health and Nutrition Examination Study, 1999-2002.

Psychoneuroendocrinology 2019 Apr 4;106:171-178. Epub 2019 Apr 4.

Department of Epidemiology, Columbia University Mailman School of Public Health, United States; Robert N. Butler Columbia Aging Center, Columbia University, United States. Electronic address:

Background: Biological processes of aging are thought to be modifiable causes of many different chronic diseases. Measures of biological aging could provide sensitive endpoints for studies of risk factors hypothesized to shorten healthy lifespan and/or interventions that extend it. But uncertainty remains about how to measure biological aging and if proposed measures assess the same thing. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.03.012DOI Listing

The Panacea of Human Aging: Calorie Restriction Versus Exercise.

Exerc Sport Sci Rev 2019 Apr 15. Epub 2019 Apr 15.

Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808.

Primary aging is the progressive decline in health and fitness and depends on metabolic rate and oxidative stress. Untoward changes in body composition and metabolic function characterizes secondary aging. We hypothesize that both exercise and calorie restriction improve secondary aging, but only calorie restriction improves primary. Read More

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http://Insights.ovid.com/crossref?an=00003677-900000000-9974
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http://dx.doi.org/10.1249/JES.0000000000000193DOI Listing
April 2019
1 Read

[Bioinformatics Analysis and Verification of Aging-Related Genes of Bone Marrow Mesenchymal Stem Cells in Patients with Acute Myeloid Leukemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):311-317

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China,E-mail:

Objective: To screen and verify the differentially expressed genes related with aging of bone marrow mesenchymal stem cells (BM-MSCs) in acute myeloid leukemia (AML) patients by bioinformatics, so as to provide new molecular markers for the research and clinical treatment of AML.

Methods: The gene expression profiling chip related with BM-MSCs in AML patients in our hospital and the gene chip GSE84881 selected from NCBI database GEO were used for data analysis and exploration. The DAVID analysis software was used to perform gene ontology (GO) enrichment analysis and KEGG pathway enrichment analysis. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.001DOI Listing

Arterial stiffness relates to executive dysfunction in later life.

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2019 Apr 18:1-12. Epub 2019 Apr 18.

a The Healthy Brain Ageing Clinic, School of Psychology , The University of Sydney , Camperdown , NSW , Australia.

Cardiovascular disease in older people is often linked with cognitive impairment, particularly in domains of executive function and processing speed. Our aims examined whether carotid-femoral pulse wave velocity (PWV) related to subtle changes of executive function and processing speed. Fifty-six individuals with subjective mood and/or cognitive concerns underwent PWV and neuropsychological assessments of processing speed (Trail Making Test Part A) and executive functioning (Delis Kaplan Executive Function System Stroop Task; Trail Making Test Part B, TMT-B). Read More

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https://www.tandfonline.com/doi/full/10.1080/13825585.2019.1
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http://dx.doi.org/10.1080/13825585.2019.1597009DOI Listing
April 2019
1 Read

Evidence against preserved syntactic comprehension in healthy aging.

J Exp Psychol Learn Mem Cogn 2019 Apr 18. Epub 2019 Apr 18.

School of Psychology.

We investigated age-related differences in syntactic comprehension in young and older adults. Most previous research found no evidence of age-related decline in syntactic processing. We investigated elementary syntactic comprehension of minimal sentences (e. Read More

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http://dx.doi.org/10.1037/xlm0000707DOI Listing

Loss of Posterior Occluding Teeth and Its Association with Protein-Micronutrients Intake and Muscle Mass among Thai Elders: A Pilot Study.

J Frailty Aging 2019 ;8(2):100-103

Dunyaporn Trachootham, Institute of Nutrition, Mahidol University, 999 Phutthamonthon Sai 4 Road, Salaya, Nakhon Pathom, Thailand, 73170. E-mail: Tel.: (66) 2 800 2380 ext.326; fax: (66) 2 441 9344.

Contact between upper and lower posterior teeth is crucial for chewing. However, the influence of posterior occluding teeth loss on protein intake and muscle mass was unclear. This cross-sectional study compared consumption frequency of protein food, amount of protein and relevant micronutrient intakes and muscle mass indices among older adults with different Eichner indices (EI) of posterior occluding teeth loss. Read More

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http://dx.doi.org/10.14283/jfa.2019.2DOI Listing
January 2019

The Association of ApoE ε4 Status with Lower Limb Function and Handgrip Strength in Older Adults.

J Frailty Aging 2019 ;8(2):62-66

Mathieu Maltais, PhD, Gérontopôle de Toulouse, Institut du Vieillissement, Bâtiment B, 37 Allée Jules Guesde, 31000, Toulouse France, +33 6 74 70 63 71, E-mail :

Background/objectives: Apolipoprotein (ApoE ε4) status has been associated with various cardiovascular diseases and Alzheimer's Disease. Some studies have found a possible relationship between the presence of an ApoE ε4 allele and the decrease of motor function in healthy older adults. The objective of this study was to measure the cross-sectional and prospective associations of ApoE ε4 status with lower limb function and handgrip strength in older adults. Read More

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http://dx.doi.org/10.14283/jfa.2019.7DOI Listing
January 2019

Multicomponent exercise and the hallmarks of frailty: Considerations on cognitive impairment and acute hospitalization.

Exp Gerontol 2019 Apr 14. Epub 2019 Apr 14.

Department of Health Sciences, Navarrabiomed, IdiSNA, CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Public University of Navarra, Pamplona, Navarra, Spain. Electronic address:

Frailty syndrome encompasses several physical hallmarks such as loss of muscle strength, power output and mass, which leads to poor gait ability, fatigue, falls and overall difficulty to perform activities of daily living. On the other hand, physical exercise interventions induce marked improvements in frailty physical hallmarks (e.g. Read More

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http://dx.doi.org/10.1016/j.exger.2019.04.007DOI Listing

Cognitive fatigue and cortical-striatal network in old age.

Aging (Albany NY) 2019 Apr 17. Epub 2019 Apr 17.

School of Nursing, University of Rochester Medical Center, Rochester, NY 14623, USA.

Cognitive fatigue (CF) is among the most common and disturbing aging symptoms, and substantially interferes with activities demanding sustained mental effort. Here we examined the relationship between the cortical-striatal network and CF (assessed by the 18-item visual analogue scale) when a group of cognitively and physically healthy older adults participated in a 30-minute cognitively fatiguing task-related fMRI experiment. We also explored whether CF would interfere with the "Posterior-Anterior Shifting in Aging" (PASA) phenomenon, an aging-associated neural reliance on frontal regions to support cognitive capacity. Read More

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http://dx.doi.org/10.18632/aging.101915DOI Listing

Free Recall of Bound Information Held in Short-Term Memory is Unimpaired by Age and Education.

Arch Clin Neuropsychol 2019 Apr 17. Epub 2019 Apr 17.

Department of Psychology, School of Social Sciences, Heriot-Watt University, Edinburgh Campus, Edinburgh, UK.

Objectives: It has been challenging to identify cognitive markers to differentiate healthy brain aging from neurodegeneration due to Alzheimer's disease (AD) that are not affected by age and education. The Short-Term Memory Binding (STMB) showed not to be affected by age or education when using the change detection paradigm. However, no previous study has tested the effect of age and education using the free recall paradigm of the STMB. Read More

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http://dx.doi.org/10.1093/arclin/acz015DOI Listing

Semantic memory, but not education or intelligence, moderates cognitive aging: a cross-sectional study.

Braz J Psychiatry 2019 Apr 15. Epub 2019 Apr 15.

Departamento de Saúde Mental, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.

Objective: Aging studies regularly assume that years of education are a protective factor for baseline cognition. In developing countries with specific sociocultural issues, this relationship may not work as expected, and an unmet need remains for alternative resilience factors. This study aimed to analyze different moderators for the relationship between aging and general cognition that could reflect better protective factors. Read More

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http://dx.doi.org/10.1590/1516-4446-2018-0290DOI Listing

Egocentric and allocentric spatial memory in healthy aging: performance on real-world tasks.

Braz J Med Biol Res 2019 15;52(4):e8041. Epub 2019 Apr 15.

Department of Psychology, University of Oviedo, Oviedo, Spain.

Although normal aging has been related to several cognitive difficulties, other processes have been studied less, such as spatial memory. Our aim was to compare egocentric and allocentric memory in an elderly population using ecological tasks. Twenty-eight cognitively unimpaired participants performed Egocentric and Allocentric Spatial Memory Tasks, as well as Spatial Span from CANTAB, Benton's Judge of Line Orientation test (JoLO), and Montreal Cognitive Assessment test (MoCA). Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1414-431X20198041DOI Listing
April 2019
1 Read

Affective theory of mind in human aging: is there any relation with executive functioning?

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2019 Apr 17:1-13. Epub 2019 Apr 17.

c Istanbul Faculty of Medicine, Department of Neurology, Behavioral Neurology and Movement Disorders Unit , Istanbul University , Istanbul , Turkey.

Theory of Mind (ToM) refers to the ability to make inferences on other's mental or emotional states. Although there is evidence suggesting that impaired executive functions due to aging could have a negative impact on cognitive ToM, there is still controversy about the effect of age and age-related executive dysfunctions on affective ToM. To investigate affective ToM in healthy aging and its relationship with executive functions, we examined Reading Mind in the Eyes Test (RMET) performance and executive functions among young and older adults. Read More

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http://dx.doi.org/10.1080/13825585.2019.1602706DOI Listing

Visual evoked and event-related brain potentials in HIV-infected adults: a longitudinal study over 2.5 years.

Doc Ophthalmol 2019 Apr 16. Epub 2019 Apr 16.

Department of Pathological Physiology, Charles University - Faculty of Medicine in Hradec Kralove, Simkova 870, 500 03, Hradec Kralove, Czech Republic.

Purpose: The aim of this neurophysiological study was to monitor changes in the visual and cognitive function of HIV-infected patients treated with combination antiretroviral therapy.

Methods: Eleven adult Czech HIV+ patients, with a mean age of 35 years and CD4 cell count ≥ 230 × 10 cells/L of blood at the time of enrollment, underwent four to six examinations over the course of 2.5 years to evaluate pattern-reversal and motion-onset visual evoked potentials (P-VEPs and M-VEPs), visually driven oddball event-related potentials (ERPs) and Montreal Cognitive Assessments. Read More

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http://dx.doi.org/10.1007/s10633-019-09697-4DOI Listing

Resilience strategies against working pressures in midwives: A qualitative study.

J Educ Health Promot 2019 15;8:33. Epub 2019 Feb 15.

Department of Nursing, School of Nursing and Midwifery, Iranian Research Center on Healthy Aging, Sabzevar University of Medical Sciences, Sabzevar, Iran.

Introduction: The lack of experienced midwifery in obstetrics and gynecology centers would have harmful consequences. Resilience could increase midwives' endurance while caring for women and neonates in the maternity hospitals. Research on resilience of midwives is rare. Read More

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http://dx.doi.org/10.4103/jehp.jehp_241_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432840PMC
February 2019
1 Read

Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan.

Proc Natl Acad Sci U S A 2019 Apr 16. Epub 2019 Apr 16.

Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461;

Accumulation of mutations in somatic cells has been implicated as a cause of aging since the 1950s. However, attempts to establish a causal relationship between somatic mutations and aging have been constrained by the lack of methods to directly identify mutational events in primary human tissues. Here we provide genome-wide mutation frequencies and spectra of human B lymphocytes from healthy individuals across the entire human lifespan using a highly accurate single-cell whole-genome sequencing method. Read More

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http://dx.doi.org/10.1073/pnas.1902510116DOI Listing
April 2019
9.809 Impact Factor

Klotho deficiency affects the spine morphology and network synchronization of neurons.

Mol Cell Neurosci 2019 Apr 13. Epub 2019 Apr 13.

Department of Neurobiology, University of Alabama at Birmingham, 1825 University Blvd. Shelby 913, Birmingham 35294, AL, USA. Electronic address:

Klotho-deficient mice rapidly develop cognitive impairment and show some evidence of the onset of neurodegeneration. However, it is impossible to investigate the long-term consequences on the brain because of the dramatic shortening of lifespan caused by systemic klotho deficiency. As klotho expression is downregulated with advancing organismal age, understanding the mechanisms of klotho action is important for developing novel strategies to support healthy brain aging. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10447431183038
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http://dx.doi.org/10.1016/j.mcn.2019.04.002DOI Listing
April 2019
4 Reads

Parkin does not prevent accelerated cardiac aging in mitochondrial DNA mutator mice.

JCI Insight 2019 Apr 16;5. Epub 2019 Apr 16.

The E3 ubiquitin ligase Parkin plays an important role in regulating clearance of dysfunctional or unwanted mitochondria in tissues, including the heart. However, whether Parkin also functions to prevent cardiac aging by maintaining a healthy population of mitochondria is still unclear. Here, we have examined the role of Parkin in the context of mtDNA damage and myocardial aging using a mouse model carrying a proofreading defective mitochondrial DNA polymerase gamma (POLG). Read More

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http://insight.jci.org/articles/view/127713
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http://dx.doi.org/10.1172/jci.insight.127713DOI Listing
April 2019
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The validity, reliability and clinical utility of a performance-based executive function assessment in people with mild to moderate dementia.

Aging Ment Health 2019 Apr 16:1-9. Epub 2019 Apr 16.

f Occupational Therapy Department , TWGHs Jockey Club Rehabilitation Complex , Aberdeen , Hong Kong.

Objective: Performance-based evaluation of executive function by using real-world daily living activities is an important area of study. This approach has been used extensively in evaluating patients after stroke or traumatic brain injury and patients with schizophrenia. Most important is the fact that until now, there has been no validated performance-based evaluation of executive function in people with dementia. Read More

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http://dx.doi.org/10.1080/13607863.2019.1599818DOI Listing

Whole-brain microstructural white matter alterations in borderline personality disorder patients.

Personal Ment Health 2019 May;13(2):96-106

Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.

Background: Borderline personality disorder (BPD) is a psychiatric condition associated with the impairment of the frontolimbic network. However, a growing body of studies suggests that brain dysfunction underling BPD could involve other brain areas. We explored the whole-brain white matter (WM) organization in BPD patients to clarify the structural pattern underlying the disease and its relationship with clinical features. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/pmh.1441
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http://dx.doi.org/10.1002/pmh.1441DOI Listing
May 2019
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A case-control analysis of maternal diet and risk of neural tube defects in Bangladesh.

Birth Defects Res 2019 Apr 15. Epub 2019 Apr 15.

Department of Neurology, Boston Children's Hospital, Boston, Massachusetts.

Objectives: Mothers need a nutrient-rich diet for healthy neural tube development. Neural tube defect risk can be reduced through fortifying grain products with folic acid and taking folic acid supplements. Fortification is not required in Bangladesh. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/bdr2.1505
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http://dx.doi.org/10.1002/bdr2.1505DOI Listing
April 2019
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Hypoxic regulation of angiotensin-converting enzyme 2 and Mas receptor in human CD34 cells.

J Cell Physiol 2019 Apr 15. Epub 2019 Apr 15.

Department of Pharmaceutical Sciences, College of Health Professions, North Dakota State University, Fargo, North Dakota.

CD34 hematopoietic stem/progenitor cells (HSPCs) are vasculogenic and hypoxia is a strong stimulus for the vasoreparative functions of these cells. Angiotensin-converting enzyme 2 (ACE2)/angiotensin-(1-7)/Mas receptor (MasR) pathway stimulates vasoprotective functions of CD34 cells. This study tested if ACE2 and MasR are involved in the hypoxic stimulation of CD34 cells. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28643
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http://dx.doi.org/10.1002/jcp.28643DOI Listing
April 2019
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Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer: a pilot longitudinal study.

Breast Cancer Res Treat 2019 Apr 13. Epub 2019 Apr 13.

Center for Cancer and Aging, City of Hope National Medical Center, Duarte, CA, USA.

Purpose: Older cancer patients are at increased risk of cancer-related cognitive impairment. The purpose of this study was to assess the alterations in intrinsic brain activity associated with adjuvant chemotherapy in older women with breast cancer.

Methods: Chemotherapy treatment (CT) group included sixteen women aged ≥ 60 years (range 60-82 years) with stage I-III breast cancers, who underwent both resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological testing with NIH Toolbox for Cognition before adjuvant chemotherapy, at time point 1 (TP1), and again within 1 month after completing chemotherapy, at time point 2 (TP2). Read More

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http://dx.doi.org/10.1007/s10549-019-05230-yDOI Listing

Aspects of exercise with person-centred guidance influencing the transition to independent exercise: a qualitative interview study among older adults with rheumatoid arthritis.

Eur Rev Aging Phys Act 2019 5;16. Epub 2019 Apr 5.

1Department of Health and Rehabilitation, Unit of Physiotherapy, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Box 455, 405 30 Göteborg, Gothenburg, Sweden.

Background: Besides being health enhancing and disease preventing, exercise is also an important part of the management of chronic conditions, including the inflammatory joint disease rheumatoid arthritis (RA). However, older adults with RA present a lower level of physical activity than healthy older adults. The aim of this qualitative study was to explore aspects of participation in moderate- to high-intensity exercise with person-centred guidance influencing the transition to independent exercise for older adults with RA. Read More

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http://dx.doi.org/10.1186/s11556-019-0211-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449916PMC

Associations between superoxide dismutase, malondialdehyde and all-cause mortality in older adults: a community-based cohort study.

BMC Geriatr 2019 Apr 15;19(1):104. Epub 2019 Apr 15.

National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, #7 Panjiayuan Nanli, Chaoyang, Beijing, 100021, China.

Background: Oxidative stress is an important theory of aging but population-based evidence has been lacking. This study aimed to evaluate the associations between biomarkers of oxidative stress, including plasma superoxide dismutase (SOD) activity and malondialdehyde (MDA), with all-cause mortality in older adults.

Methods: This is a community-based cohort study of 2224 participants (women:1227, median age: 86 years). Read More

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http://dx.doi.org/10.1186/s12877-019-1109-zDOI Listing
April 2019
2.000 Impact Factor

Women Caring for Our Aging in Place Seniors Will Lose Out because of U.S. Immigration Policies.

Authors:
Stephen M Golant

J Aging Soc Policy 2019 Apr 15:1-8. Epub 2019 Apr 15.

a Professor Emeritus, Department of Geography , University of Florida , Gainesville , USA.

Most older people experiencing chronic health problems, physical disabilities, and memory losses are still able to age in place in their own homes. However, they often need help from others to enjoy healthy, active, and independent lives. They turn mostly to family members, mainly women and usually their daughters, daughters-in-law or wives. Read More

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http://dx.doi.org/10.1080/08959420.2019.1603535DOI Listing

Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells.

Nucleic Acids Res 2019 Feb 14. Epub 2019 Feb 14.

Center for Healthy Aging, SUND, University of Copenhagen, 2200 Copenhagen N, Denmark.

Ataxia with oculomotor apraxia type 1 (AOA1) is an early onset progressive spinocerebellar ataxia caused by mutation in aprataxin (APTX). APTX removes 5'-AMP groups from DNA, a product of abortive ligation during DNA repair and replication. APTX deficiency has been suggested to compromise mitochondrial function; however, a detailed characterization of mitochondrial homeostasis in APTX-deficient cells is not available. Read More

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http://dx.doi.org/10.1093/nar/gkz083DOI Listing
February 2019

Functional reorganization of neural networks involved in emotion regulation following trauma therapy for complex trauma disorders.

Neuroimage Clin 2019 Apr 2;23:101807. Epub 2019 Apr 2.

Clienia Littenheid AG, Hospital for Psychiatry and Psychotherapy, Littenheid, Switzerland; Department of Psychiatry, Psychotherapy, and Psychosomatics, University Hospitals and University of Halle (Saale), Halle, Germany.

Objectives: We investigated whether patients with complex interpersonal trauma engage neural networks that are commonly activated during cognitive reappraisal and responding naturally to affect-laden images. In this naturalistic study, we examined whether trauma treatment not only reduces symptoms but also changes neural networks involved in emotional control.

Methods: Before and after eight weeks of phase-oriented inpatient trauma treatment, patients (n = 28) with complex posttraumatic stress disorder (cPTSD) and complex dissociative disorders (CDD) performed a cognitive reappraisal task while electroencephalography (EEG) was registered. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22131582193015
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http://dx.doi.org/10.1016/j.nicl.2019.101807DOI Listing
April 2019
2 Reads

White matter integrity in brain structures supporting semantic processing is associated with value-directed remembering in older adults.

Neuropsychologia 2019 Apr 12. Epub 2019 Apr 12.

Department of Psychology, University of California, Los Angeles, USA.

White matter microstructure changes substantially in aging. To better understand how the integrity of white matter structures supports the selective learning of rewarding material, 23 healthy older adults were tested on a value-directed remembering task. This task involved successive free recall word lists where items differed in importance, as denoted by value cues preceding each word. Read More

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http://dx.doi.org/10.1016/j.neuropsychologia.2019.04.003DOI Listing

Mild Behavioral Impairment: presentation of the diagnostic criteria and the Italian version of the MBI-Checklist.

Riv Psichiatr 2019 Mar-Apr;54(2):59-66

Department of Experimental and Clinical Medicine, Section of Psychiatry, University of Pisa, Italy - Institute of Behavioural Science "G. De Lisio", Pisa, Italy.

Neuropsychiatric symptoms (NPS) are common in the prodromal stage of dementia and can precede the onset of cognitive impairment. The presence of NPS in cognitively normal patients or in patients with Mild Cognitive Impairment (MCI) is associated with an increased risk of progression along the neurodegenerative process. The need to identify, in the early stages of the disease, the population at risk of cognitive decline has led to the formulation of the concept of Mild Behavioral Impairment (MBI). Read More

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http://www.rivistadipsichiatria.it/articoli.php?archivio=yes
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http://dx.doi.org/10.1708/3142.31246DOI Listing
April 2019
1 Read

Effectiveness of a multi-faceted intervention among elementary school children.

Medicine (Baltimore) 2019 Apr;98(15):e15079

Laboratory for Epidemiology, Department of Health Care Management, and Healthy Aging Research Center, Chang-Gung University.

Childhood obesity has been shown to be closely related to future obesity and comorbidities. As its prevalence and impact has increased significantly worldwide, researchers have focused on prevention and intervention. This study assessed a multifaceted intervention for elementary school children. Read More

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http://dx.doi.org/10.1097/MD.0000000000015079DOI Listing
April 2019
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Analytical performance of a single epitope B-type natriuretic peptide sandwich immunoassay on the Minicare platform for point-of-care diagnostics.

Pract Lab Med 2019 May 17;15:e00119. Epub 2019 Mar 17.

Department of Internal Medicine III - Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria.

Point-of-care B-type natriuretic peptide (BNP) testing with adequate analytical performance has the potential to improve patient flow and provide primary care givers with easy-to-use advanced diagnostic tools in the management of heart failure. We present the analytical evaluation of the Minicare BNP immunoassay under development on the Minicare I-20 platform for point-of-care testing. Analytical performance was evaluated using EDTA venous whole blood, EDTA plasma and capillary whole blood. Read More

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http://dx.doi.org/10.1016/j.plabm.2019.e00119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444177PMC

Effects of low visual acuity on neuropsychological test scores: A simulation study.

Clin Neuropsychol 2019 Apr 15:1-18. Epub 2019 Apr 15.

a Department of Clinical and Developmental Neuropsychology , University of Groningen , Groningen , The Netherlands.

Objective: To systematically examine the effect of low visual acuity (LVA) on a number of commonly used neuropsychological tests.

Method: In this study, the influence of LVA on a number of commonly used neuropsychological tests was examined in 238 healthy older adults (aged 50-80) without visual or neurological impairment. LVA was simulated using simulation glasses. Read More

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https://www.tandfonline.com/doi/full/10.1080/13854046.2019.1
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http://dx.doi.org/10.1080/13854046.2019.1596315DOI Listing
April 2019
1 Read

How indigenous mothers experience selecting and using early childhood development services to care for their infants.

Int J Qual Stud Health Well-being 2019 Apr 15:1601486. Epub 2019 Apr 15.

b School of Nursing , McMaster University , Hamilton , Canada.

Purpose: Promoting a child's healthy growth and development in the first six years of life is critical to their later health and well-being. Indigenous infants experience poorer health outcomes than non-Indigenous infants, yet little is understood about how parents access and use health services to optimize their infants' growth and development. Exploring the experiences of Indigenous mothers who select and use early childhood development (ECD) services provides important lessons into how best to promote their access and use of health services. Read More

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http://dx.doi.org/10.1080/17482631.2019.1601486DOI Listing
April 2019
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Towards understanding neural network signatures of motor skill learning in parkinson's disease and healthy aging.

Br J Radiol 2019 Apr 14:20190071. Epub 2019 Apr 14.

1 Department of Rehabilitation Sciences, KU Leuven , Leuven , Belgium.

In the past decade, neurorehabilitation has been shown to be an effective therapeutic supplement for patients with Parkinson's disease (PD). However, patients still experience severe problems with the consolidation of learned motor skills. Knowledge on the neural correlates underlying this process is thus essential to optimize rehabilitation for PD. Read More

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http://dx.doi.org/10.1259/bjr.20190071DOI Listing

Associations between long-term adherence to healthy diet and recurrent depressive symptoms in Whitehall II Study.

Eur J Nutr 2019 Apr 13. Epub 2019 Apr 13.

Inserm, U1198, University of Montpellier, Ecole Pratique des Hautes Etudes, PSL Research University, Montpellier, 34095, France.

Purpose: We examined whether long-term adherence to three diet quality scores-the Alternative Healthy Eating Index-2010 (AHEI-2010), Dietary Approach to Stop Hypertension (DASH) and  transformed-Mediterranean Diet Score (tMDS), Alternative Healthy Eating Index-2010 (AHEI-2010) and Dietary Approach to Stop Hypertension (DASH) is associated with the risk of recurrent depressive symptoms.

Methods: Analyses were conducted on a sample of 4949 men and women from the Whitehall II study. Diet scores were calculated using data collected from food frequency questionnaires repeated over 11 years of exposure (1991/1993-2002/2004). Read More

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http://dx.doi.org/10.1007/s00394-019-01964-zDOI Listing

A Western-type dietary pattern and atorvastatin induce epicardial adipose tissue interferon signaling in the Ossabaw pig.

J Nutr Biochem 2019 Feb 20;67:212-218. Epub 2019 Feb 20.

Cardiovascular Nutrition Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA. Electronic address:

Epicardial adipose tissue (EAT) inflammation is thought to potentiate the development of coronary artery disease (CAD). Overall diet quality and statin therapy are important modulators of inflammation and CAD progression. Our objective was to examine the effects and interaction of dietary patterns and statin therapy on EAT gene expression in the Ossabaw pig. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2019.02.003DOI Listing
February 2019

Influence of changes in diet quality on unhealthy aging: the Seniors-ENRICA cohort.

Am J Med 2019 Apr 11. Epub 2019 Apr 11.

Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid and Idipaz. Madrid, Spain; CIBER of Epidemiology and Public Health (CIBERESP). Madrid, Spain; IMDEA Food Institute, CEI UAM+CSIC. Madrid, Spain. Electronic address:

Background: Whether adopting a better diet in late life influences the aging process is still uncertain. Thus, we examined the association between changes in diet quality and unhealthy aging.

Methods: Data came from 2042 individuals aged ≥60years recruited in the Seniors-ENRICA cohort in 2008-2010 (wave 0) and followed-up in 2012 (wave 1) and 2015 (wave 2). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029343193030
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http://dx.doi.org/10.1016/j.amjmed.2019.03.023DOI Listing
April 2019
4 Reads

Skin sebum and skin elasticity: Major influencing factors for facial pores.

J Cosmet Dermatol 2019 Apr 13. Epub 2019 Apr 13.

Faculty of Pharmacy and Alternative Medicine, Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.

Objective: The current research work was initiated to develop anti-aging phytocosmetic formulation of phytoantioxidant, to evaluate their effect on human skin, and to link R parameters of skin with skin sebum and aging.

Methods: According to COLIPA, 10 healthy male volunteers, aged between 20 and 30 years, having no skin infection or other hypersensitivity disorders, were included in the study. The effect of formulation was evaluated on skin pores and skin elasticity on cheeks for 90 days at regular interval. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.12933
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http://dx.doi.org/10.1111/jocd.12933DOI Listing
April 2019
1 Read

Age-Related Differences in Motivational Integration and Cognitive Control.

Cogn Affect Behav Neurosci 2019 Apr 12. Epub 2019 Apr 12.

Cognitive Control and Psychopathology Laboratory, Psychological and Brain Sciences, Washington University in St. Louis, 1 Brookings Drive, Campus Box 1125, St. Louis, MO, 63130, USA.

Motivational incentives play an influential role in value-based decision-making and cognitive control. A compelling hypothesis in the literature suggests that the motivational value of diverse incentives are integrated in the brain into a common currency value signal that influences decision-making and behavior. To investigate whether motivational integration processes change during healthy aging, we tested older (N = 44) and younger (N = 54) adults in an innovative incentive integration task paradigm that establishes dissociable and additive effects of liquid (e. Read More

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http://link.springer.com/10.3758/s13415-019-00713-3
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http://dx.doi.org/10.3758/s13415-019-00713-3DOI Listing
April 2019
1 Read

The NaK-ATPase Inhibitor Marinobufagenin and Early Cardiovascular Risk in Humans: a Review of Recent Evidence.

Curr Hypertens Rep 2019 Apr 12;21(5):38. Epub 2019 Apr 12.

Hypertension in Africa Research Team (HART), North-West University, Private Bag X1290, Potchefstroom, 2520, South Africa.

Purpose Of Review: This review synthesizes recent findings in humans pertaining to the relationships between marinobufagenin (MBG), a steroidal Na/K-ATPase inhibitor and salt-sensitivity biomarker, and early cardiovascular risk markers.

Recent Findings: Twenty-four-hour urinary MBG strongly associates with habitual salt intake in young healthy adults (aged 20-30 years). Furthermore, in young healthy adults free of detected cardiovascular disease, MBG associates with increased large artery stiffness and left ventricular mass independent of blood pressure. Read More

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http://dx.doi.org/10.1007/s11906-019-0942-yDOI Listing

Distinct FP-CIT PET patterns of Alzheimer's disease with parkinsonism and dementia with Lewy bodies.

Eur J Nucl Med Mol Imaging 2019 Apr 12. Epub 2019 Apr 12.

Department of Neurology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 30722, South Korea.

Purpose: Little is known regarding the clinical relevance or neurobiology of subtle motor disturbance in Alzheimer's disease (AD). This study aims to investigate the patterns of striatal F-FP-CIT uptake in patients with AD-related cognitive impairment (ADCI) with mild parkinsonism.

Methods: We recruited 29 consecutive patients with ADCI with mild parkinsonism. Read More

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http://dx.doi.org/10.1007/s00259-019-04315-6DOI Listing
April 2019
5.383 Impact Factor

Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation.

J Clin Med 2019 Apr 11;8(4). Epub 2019 Apr 11.

Department of Health and Kinesiology, Texas A&M University, College Station, TX 77843-4253, USA.

Sarcopenia, defined as the age-related decrease in muscle mass, strength and physical performance, is associated with reduced bone mass and elevated low-grade inflammation. From a healthy aging perspective, interventions which overcome sarcopenia are clinically relevant. Accumulating evidence suggests that exogenous creatine supplementation has the potential to increase aging muscle mass, muscle performance, and decrease the risk of falls and possibly attenuate inflammation and loss of bone mineral. Read More

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http://dx.doi.org/10.3390/jcm8040488DOI Listing

Decrypting the electrophysiological individuality of the human brain: Identification of individuals based on resting-state EEG activity.

Neuroimage 2019 Apr 9. Epub 2019 Apr 9.

Division Neuropsychology, Institute of Psychology, University of Zurich, Switzerland; University Research Priority Program (URPP) "Dynamic of Healthy Aging", University of Zurich, Switzerland. Electronic address:

Biometric identification (BI) of individuals is a fast-growing field of research that is producing increasingly sophisticated applications in several spheres of everyday life. Previous magnetic resonance imaging (MRI) studies have demonstrated that based on the high inter-individual variability of brain structure and function, it is possible to identify individuals with high accuracy. Otherwise, there is the common belief that electroencephalographic (EEG) data recorded at the surface of the scalp are too noisy for identification purposes with a comparably high hit rate. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.04.005DOI Listing
April 2019
2 Reads

Plasma metabolomics in early Alzheimer's disease patients diagnosed with amyloid biomarker.

J Proteomics 2019 Apr 9;200:144-152. Epub 2019 Apr 9.

Neonatal Research Unit, Health Research Institute La Fe, Valencia, Spain. Electronic address:

An untargeted metabolomics study has been carried out using plasma samples from patients with Mild Cognitive Impairment due to Alzheimer's disease patients (MCI-AD, n = 29) and healthy people (n = 29)). They have been classified following the National Institute on Aging and Alzheimer's Association (NIA-AA) recommendations and cerebrospinal fluid biomarkers. The analytical method was based on liquid chromatography coupled to high resolution mass spectrometry. Read More

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http://dx.doi.org/10.1016/j.jprot.2019.04.008DOI Listing
April 2019
4 Reads

Are low to moderate average alcohol consumption and isolated episodes of binge drinking in early pregnancy associated with facial features related to fetal alcohol syndrome in five-year-old children?

Alcohol Clin Exp Res 2019 Apr 12. Epub 2019 Apr 12.

Departments of Epidemiology and Pediatrics, University of Washington, Seattle, WA, USA.

Background: Fetal alcohol syndrome (FAS) typically is observed among individuals with high prenatal alcohol exposures (PAE), but exposure histories obtained in clinical diagnostic settings are often inaccurate. The present analysis used the Lifestyle During Pregnancy Study (LDPS) to assess the potential effects of low to moderate average weekly alcohol consumption and binge drinking in early pregnancy on facial features associated with FAS among children five years of age.

Methods: The analysis is a prospective follow-up study of 670 women and their children sampled from the LDPS cohort based on maternal alcohol consumption during pregnancy. Read More

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http://dx.doi.org/10.1111/acer.14047DOI Listing
April 2019
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Greater Peri-Aortic Fat Volume at Midlife is Associated with Slower Gait Speed Later in Life in Women: The SWAN Cardiovascular Fat Ancillary Study.

J Gerontol A Biol Sci Med Sci 2019 Apr 12. Epub 2019 Apr 12.

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Background: Higher perivascular adipose tissue (PVAT) contributes to adverse physiologic alterations in the vascular wall, and thus could potentially limit normal physical function later in life. We hypothesize that higher PVAT volume at midlife is prospectively associated with slower gait speed later in life, independent of overall adiposity and other risk factors.

Methods: Participants from the Study of Women's Health Across the Nation (SWAN) cardiovascular fat ancillary study were included. Read More

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http://dx.doi.org/10.1093/gerona/glz095DOI Listing

Action observation therapy for improving arm function, walking ability, and daily activity performance after stroke: a systematic review and meta-analysis.

Clin Rehabil 2019 Apr 12:269215519839108. Epub 2019 Apr 12.

1 Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung University, Taoyuan.

Objective: This study was to investigate the effectiveness of action observation therapy on arm and hand motor function, walking ability, gait performance, and activities of daily living in stroke patients.

Design: Systematic review and meta-analysis of randomized controlled trials.

Data Sources: Searches were completed in January 2019 from electronic databases, including PubMed, Scopus, the Cochrane Library, and OTseeker. Read More

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http://dx.doi.org/10.1177/0269215519839108DOI Listing

Canadians with visual impairment utilize home care services more frequently.

Can J Ophthalmol 2019 Apr 18;54(2):196-202. Epub 2018 May 18.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ont.; Dalla Lana School of Public Health, University of Toronto, Toronto, Ont.. Electronic address:

Objective: To assess the impact of presenting visual impairment (PVI) on the utilization of formal home care services in Canada. Formal home care services were defined as services provided by professionals. Presenting visual impairment was self-reported impaired vision. Read More

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http://dx.doi.org/10.1016/j.jcjo.2018.03.007DOI Listing

Polyphenols in Almond Skins after Blanching Modulate Plasma Biomarkers of Oxidative Stress in Healthy Humans.

Antioxidants (Basel) 2019 Apr 10;8(4). Epub 2019 Apr 10.

Antioxidants Research Laboratory, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.

Almond skins are a waste byproduct of blanched almond production. Polyphenols extracted from almond skins possess antioxidant activities in vitro and in vivo. Thus, we examined the pharmacokinetic profile of almond skin polyphenols (ASP) and their effect on measures of oxidative stress. Read More

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http://dx.doi.org/10.3390/antiox8040095DOI Listing