1,242,434 results match your criteria Healthcare informatics : the business magazine for information and communication systems[Journal]


Correlation of perioperative risk scores with hospital costs in neurosurgical patients.

J Neurosurg 2019 Feb 15:1-7. Epub 2019 Feb 15.

2Department of Neurosurgery, University of Florida, Gainesville, Florida.

OBJECTIVEThe American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) online surgical risk calculator uses inherent patient characteristics to provide predictive risk scores for adverse postoperative events. The purpose of this study was to determine if predicted perioperative risk scores correlate with actual hospital costs.METHODSA single-center retrospective review of 1005 neurosurgical patients treated between September 1, 2011, and December 31, 2014, was performed. Read More

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http://dx.doi.org/10.3171/2018.10.JNS182041DOI Listing
February 2019

Marital quality, partner's engagement and continuous positive airway pressure adherence in obstructive sleep apnea.

Sleep Med 2018 Dec 26;55:56-61. Epub 2018 Dec 26.

HP2 Laboratory, INSERM U1042, Univ. Grenoble Alpes, Grenoble, France; EFCR Laboratory, Grenoble Alpes University Hospital, Grenoble, France. Electronic address:

Background: Continuous positive airway pressure (CPAP) is the first line therapy for obstructive sleep apnea (OSA) but its effectiveness requires high adherence. We aimed to assess the impacts of the spouse's/partner's involvement and the quality of the couple's relationship on CPAP adherence.

Methods: In a multicenter prospective study conducted in France, patients reported their subjective views regarding their partner's engagement in their CPAP treatment and the quality of their marital relationship using the Quality of Marriage Index. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.12.009DOI Listing
December 2018

Inadequate prenatal care utilization among women with and without methadone-treated opioid use disorders in Taiwan.

Int J Drug Policy 2019 Feb 13;67:1-8. Epub 2019 Feb 13.

Children and Family Research Center, National Taiwan University, Taipei, Taiwan.

Aims: The present study aims to investigate the utilization pattern of prenatal care and correlates for women with opioid use disorders (OUD) in Taiwan.

Method: Using the data linkage between the Methadone Maintenance Treatment (MMT) register with national health insurance, national birth notification system, and birth registration system, we identified 1712 pregnancies with 20 or more gestational weeks from women enrolled in the MMT (heroin-exposed: receiving no methadone treatment during pregnancy, n = 1053 by 882 women; methadone-treated: receiving methadone for at least one day during pregnancy, n = 659 by 574 women) and their 1:10 matched pregnancies from 17,060 women without substance use disorder in the period of 2004-2013. The generalized linear mixed models with negative binomial and logit distributions were performed to evaluate the relationship between individual sociodemographic, health, and addiction treatment characteristics with the number of prenatal visits and receiving prenatal care in the first trimester (i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09553959193003
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http://dx.doi.org/10.1016/j.drugpo.2019.01.024DOI Listing
February 2019
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'Poetry in motion' a place in the classroom: Using poetry to develop writing confidence and reflective skills.

Nurse Educ Today 2019 Feb 6;76:73-77. Epub 2019 Feb 6.

University of Essex, Wivenhoe Park, Colchester CO4 3SQ, United Kingdom of Great Britain and Northern Ireland. Electronic address:

Background: Non-traditional students entering nursing programmes at university often experience difficulties with the academic literacy requirements of their courses, in particular academic and reflective writing. Levels of student anxiety may also be affected by other issues including the pressures of managing work, family and study commitments.

Objectives: To explore how classroom-based poetry writing activities might support students in developing their skills as student-writers and reflective practitioners. Read More

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http://dx.doi.org/10.1016/j.nedt.2019.01.026DOI Listing
February 2019

Stroke occurrence while on antiplatelet therapy may predict atrial fibrillation detected after stroke.

Atherosclerosis 2019 Jan 24;283:13-18. Epub 2019 Jan 24.

Division of Neurology, Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City, Taiwan; Department of Information Management and Institute of Healthcare Information Management, National Chung Cheng University, Chiayi County, Taiwan. Electronic address:

Background And Aims: Stroke occurrence while on antiplatelet therapy, i.e., a breakthrough stroke, is often conveniently attributed to antiplatelet resistance. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.01.007DOI Listing
January 2019

Polymers with distinctive anticancer mechanism that kills MDR cancer cells and inhibits tumor metastasis.

Biomaterials 2019 Jan 25;199:76-87. Epub 2019 Jan 25.

Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, 138669, Singapore. Electronic address:

Although mortality continues to decline over the past two decades, cancer is still a pervasive healthcare problem worldwide due to the increase in the number of cases, multidrug resistance (MDR) and metastasis. As a consequence of multidrug resistance, cancer treatment must rely on a host of chemotherapeutic agents and chemosensitizers to achieve remission. To overcome these problems, a series of biodegradable triblock copolymers of PEG, guanidinium-functionalized polycarbonate and polylactide (PEG-PGC-PDLA) is designed as chemotherapeutic agents. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.036DOI Listing
January 2019

Advances in Immunotherapy Delivery from Implantable and Injectable Biomaterials.

Acta Biomater 2019 Feb 13. Epub 2019 Feb 13.

Department of Chemistry, Department of Bioengineering, Rice University, Houston, TX 77005, United states. Electronic address:

Macroscale biomaterials, such as preformed implantable scaffolds and injectable soft materials, possess powerful synergies with anti-cancer immunotherapies. Immunotherapies on their own typically have poor delivery properties, and often require repeated high-dose injections that result in serious off-tumor effects and/or limited efficacy. Rationally designed biomaterials allow for discrete localization and controlled release of immunotherapeutic agents, and have been shown in a large number of applications to improve outcomes in the treatment of cancers via immunotherapy. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.016DOI Listing
February 2019

Universal screening for Clostridioides difficile in a tertiary hospital: risk factors for carriage and clinical disease.

Clin Microbiol Infect 2019 Feb 13. Epub 2019 Feb 13.

Internal Medicine C, Sheba Medical Center, Israel; Sackler school of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objectives: The role of asymptomatic carriers in CDI epidemiology is not fully understood. Our aim was to evaluate CD carriage prevalence on admission, associated risk factors and the risk to develop CDI.

Methods: A ten-week surveillance program for CD carriage of all medical patients admitted to the Sheba Medical Center was implemented, utilizing admission rectal swab PCR (Xpert C. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.02.002DOI Listing
February 2019

Insight into Imiquimod Skin Permeation and Increased Delivery Using Microneedle Pre-treatment.

Eur J Pharm Biopharm 2019 Feb 13. Epub 2019 Feb 13.

Division of Advanced Materials and Healthcare Technologies, School of Pharmacy, The University of Nottingham, NG7 2RD, UK. Electronic address:

Basal cell carcinoma (BCC) is the most common skin cancer in humans. Topical treatment with imiquimod provides a non-invasive, self-administered treatment with relatively low treatment cost. Despite displaying excellent efficacy, imiquimod is only licensed by the FDA for superficial BCC. Read More

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http://dx.doi.org/10.1016/j.ejpb.2019.02.006DOI Listing
February 2019

Evaluation of the sensitivity of Rρ MRI to pH and macromolecular density.

Magn Reson Imaging 2019 Feb 13. Epub 2019 Feb 13.

Department of Radiology, Box 218, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, United Kingdom, CB2 0QQ. Electronic address:

The tumor microenvironment is characteristically acidic and this extracellular acidosis is known to play a role in carcinogenesis and metastasis and can affect tumor chemosensitivity and radiosensitivity. Intracellular pH has been used as a possible biomarker of salvageable tissue in ischemic stroke. A non-invasive MRI-based approach for the determination and imaging of cerebral pH would be a powerful tool in cancer diagnosis and monitoring, as well as stroke treatment planning. Read More

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http://dx.doi.org/10.1016/j.mri.2019.02.004DOI Listing
February 2019

5-Year Outcomes of a Single Institution Prospective Trial of 19 Gy Single-Fraction HDR Brachytherapy for Low- and Intermediate-Risk Prostate Cancer.

Int J Radiat Oncol Biol Phys 2019 Feb 13. Epub 2019 Feb 13.

Department of Radiation Oncology, Beaumont Health System, Royal Oak, MI. Electronic address:

Purpose: To update outcome and toxicity results of a prospective trial of 19 Gy single-fraction high-dose-rate (HDR) brachytherapy for men with low- and intermediate-risk prostate cancer.

Materials And Methods: Patients were treated on a prospective study of single-fraction HDR brachytherapy. All patients had low- or intermediate-risk prostate cancer. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.02.010DOI Listing
February 2019

Correlation of Outer Retinal Degeneration and Choriocapillaris Loss in Stargardt disease using en face OCT and OCT Angiography.

Am J Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Casey Eye Institute, Oregon Health & Science University, Portland, OR, United States. Electronic address:

Purpose: Measure and correlate degeneration of the inner segment/outer segment junction (IS/OS), retinal pigment epithelium (RPE) and choriocapillaris (CC) in Stargardt disease (STGD) DESIGN: Prospective cross-sectional study METHODS SETTING: Casey Eye Institute POPULATION: 23 patients with STGD PROCEDURES: OCT angiography (OCTA) scans were centered on the fovea. OCT slab projection and en face boundary maps were used to create masks to measure total IS/OS loss or RPE atrophy, as well as regions of isolated IS/OS loss, isolated RPE atrophy, matched IS/OS and RPE degeneration, or intact IS/OS and RPE. CC vascular density (CCVD) was quantified from CC angiogram. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.007DOI Listing
February 2019

Effects of amantadine on corneal endothelium.

Exp Eye Res 2019 Feb 13. Epub 2019 Feb 13.

Ross Eye Institute, Department of Ophthalmology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA; Research and Ophthalmology Services, Veterans Administration of Western New York Healthcare System, Buffalo, NY, USA. Electronic address:

Purpose: An adverse effect of amantadine, a drug used for Parkinson's disease, is corneal edema. While corneal endothelial cell loss is noted with amantadine toxicity, the reversibility of corneal edema suggests that amantadine affects active mechanisms regulating corneal hydration. Although mainly known as a NMDA receptor antagonist, amantadine is also a K-channel blocker. Read More

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http://dx.doi.org/10.1016/j.exer.2019.02.010DOI Listing
February 2019

Clinical and Economic Burden of Patients with Chronic Hepatitis C with Versus Without Antiviral Treatment in Japan: An Observational Cohort Study Using Hospital Claims Data.

Infect Dis Ther 2019 Feb 15. Epub 2019 Feb 15.

AbbVie Inc., North Chicago, IL, USA.

Introduction: Japan has one of the highest prevalence rate of chronic hepatitis C (CHC) in the industrialized world. However, the burden of CHC treatment is poorly understood. Thus, the healthcare resource utilization and costs of treated versus untreated patients, and patients with early versus delayed treatment initiation, were assessed in Japan. Read More

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http://dx.doi.org/10.1007/s40121-019-0234-5DOI Listing
February 2019

Understanding Skin Screening Practices Among Children at Elevated Risk for Melanoma to Inform Interventions for Melanoma Prevention and Control.

J Cancer Educ 2019 Feb 15. Epub 2019 Feb 15.

Huntsman Cancer Institute, 2000 Circle of Hope, Rm 4509, Salt Lake City, UT, 84112, USA.

Melanoma is the deadliest form of skin cancer. Screening can aid in early disease detection, when treatment is more effective. Although there are currently no consensus guidelines regarding skin screening for pediatric populations with elevated familial risk for melanoma, at-risk children with the help of their parents and healthcare providers may implement skin self-exams. Read More

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http://dx.doi.org/10.1007/s13187-019-01489-3DOI Listing
February 2019

Semantic data interoperability, digital medicine, and e-health in infectious disease management: a review.

Eur J Clin Microbiol Infect Dis 2019 Feb 15. Epub 2019 Feb 15.

bioMérieux, 3 route de Port Michaud, 38390, La Balme Les Grottes, France.

Disease management requires the use of mixed languages when discussing etiology, diagnosis, treatment, and follow-up. All phases require data management, and, in the optimal case, such data are interdisciplinary and uniform and clear to all those involved. Such semantic data interoperability is one of the technical building blocks that support emerging digital medicine, e-health, and P4-medicine (predictive, preventive, personalized, and participatory). Read More

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http://dx.doi.org/10.1007/s10096-019-03501-6DOI Listing
February 2019

Dynamic gas extraction of iodine in combination with a silver triangular nanoplate-modified paper strip for colorimetric determination of iodine and of iodine-interacting compounds.

Mikrochim Acta 2019 Feb 15;186(3):188. Epub 2019 Feb 15.

Department of Chemistry, Lomonosov Moscow State University, Leninskie gory, 1/3, 119991, Moscow, Russia.

A method is described for sensitive and selective detection of iodine by using a paper strip modified with silver triangular nanoplates (AgTNPs). It is based on the extraction of iodine from a solution into a flow of air via dynamic gas extraction and transferring it through a reactive paper modified with AgTNPs. The interaction of AgTNPs with iodine results in a color change from blue to white. Read More

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http://dx.doi.org/10.1007/s00604-019-3300-5DOI Listing
February 2019

[Care planning for people with dementia on the margins of care between home care and nursing home: the balance of care approach in the RightTimePlaceCare project in Germany].

Z Gerontol Geriatr 2019 Feb 15. Epub 2019 Feb 15.

Medizinische Fakultät, Institut für Gesundheits- und Pflegewissenschaft, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Straße 8, 06112, Halle (Saale), Deutschland.

Background: The balance of care approach is a strategic planning framework that can be used to research the adequacy of care arrangements and the cost implications. It seeks to identify people who are on the margins of care, i. e. Read More

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http://dx.doi.org/10.1007/s00391-019-01510-wDOI Listing
February 2019

Quantification of myocardial deformation by deformable registration-based analysis of cine MRI: validation with tagged CMR.

Eur Radiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Medical Imaging, University Health Network, 1 PMB-273, 585 University Avenue, Toronto, Ontario, M5G 2N2, Canada.

Objectives: To validate deformable registration algorithms (DRAs) for cine balanced steady-state free precession (bSSFP) assessment of global longitudinal strain (GLS) and global circumferential strain (GCS) using harmonic phase (HARP) cardiovascular magnetic resonance as standard of reference (SoR).

Methods: Seventeen patients and 17 volunteers underwent short axis stack and 2-/4-chamber cine bSSFP imaging with matching slice long-axis and mid-ventricular spatial modulation of magnetization (SPAMM) myocardial tagging. Inverse DRA was applied on bSSFP data for assessment of GLS and GCS while myocardial tagging was processed using HARP. Read More

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http://dx.doi.org/10.1007/s00330-019-06019-9DOI Listing
February 2019

Radiomics in multiple sclerosis and neuromyelitis optica spectrum disorder.

Eur Radiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, People's Republic of China.

Objective: To develop and validate an individual radiomics nomogram for differential diagnosis between multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD).

Methods: We retrospectively collected 67 MS and 68 NMOSD with spinal cord lesions as a primary cohort and prospectively recruited 28 MS and 26 NMOSD patients as a validation cohort. Radiomic features were extracted from the spinal cord lesions. Read More

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http://dx.doi.org/10.1007/s00330-019-06026-wDOI Listing
February 2019

Artificial intelligence in neuropathology: deep learning-based assessment of tauopathy.

Lab Invest 2019 Feb 15. Epub 2019 Feb 15.

Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

Accumulation of abnormal tau in neurofibrillary tangles (NFT) occurs in Alzheimer disease (AD) and a spectrum of tauopathies. These tauopathies have diverse and overlapping morphological phenotypes that obscure classification and quantitative assessments. Recently, powerful machine learning-based approaches have emerged, allowing the recognition and quantification of pathological changes from digital images. Read More

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http://dx.doi.org/10.1038/s41374-019-0202-4DOI Listing
February 2019

A mathematical-descriptor of tumor-mesoscopic-structure from computed-tomography images annotates prognostic- and molecular-phenotypes of epithelial ovarian cancer.

Nat Commun 2019 Feb 15;10(1):764. Epub 2019 Feb 15.

Cancer Imaging Centre, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, W12 0HS, UK.

The five-year survival rate of epithelial ovarian cancer (EOC) is approximately 35-40% despite maximal treatment efforts, highlighting a need for stratification biomarkers for personalized treatment. Here we extract 657 quantitative mathematical descriptors from the preoperative CT images of 364 EOC patients at their initial presentation. Using machine learning, we derive a non-invasive summary-statistic of the primary ovarian tumor based on 4 descriptors, which we name "Radiomic Prognostic Vector" (RPV). Read More

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http://dx.doi.org/10.1038/s41467-019-08718-9DOI Listing
February 2019

Replication competence of virions induced from CD4+ lymphocytes latently infected with HIV.

Retrovirology 2019 Feb 15;16(1). Epub 2019 Feb 15.

San Diego Veterans Affairs Healthcare System, San Diego, CA, USA.

Latently infected CD4 lymphocytes preclude cure of HIV infection, even with the most effective antiretroviral therapy. The replication competent latent HIV reservoir has been quantified with the terminal dilution quantitative viral outgrowth assay, which induces virus propagation in CD4 T cell culture supernatants following cellular activation. Efforts to improve the sensitivity of this inefficient assay have introduced more sensitive p24 ELISA and RNA PCR based endpoints, but these more sensitive endpoints have raised the question whether they are measuring induced replication competent or defective virions. Read More

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http://dx.doi.org/10.1186/s12977-019-0466-1DOI Listing
February 2019

Epidemiological characteristics and trends of a Nationwide measles outbreak in Mongolia, 2015-2016.

BMC Public Health 2019 Feb 15;19(1):201. Epub 2019 Feb 15.

Department of Healthcare Administration, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Background: Mongolia was one of the four countries that received a measles-elimination certificate from the World Health Organization Regional Office for the Western Pacific in 2014. Following the outbreaks in many countries including China, a large measles outbreak occurred in Mongolia in 2015. This study reports 2015-2016 measles outbreak incidence, mortality, and complications, according to time, geographical distribution, and host characteristics. Read More

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http://dx.doi.org/10.1186/s12889-019-6511-0DOI Listing
February 2019

The feasibility of assessing frailty and sarcopenia in hospitalised older people: a comparison of commonly used tools.

BMC Geriatr 2019 Feb 15;19(1):42. Epub 2019 Feb 15.

Academic Geriatric Medicine, University of Southampton, Southampton, UK.

Background: Frailty and sarcopenia are common amongst hospitalised older people and associated with poor healthcare outcomes. Widely recognised tools for their identification are the Fried Frailty Phenotype, its self-report version the FRAIL Scale, and the European Working Group on Sarcopenia in Older People (EWGSOP) criteria. We studied the feasibility of using these tools in a hospital setting of acute wards for older people. Read More

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http://dx.doi.org/10.1186/s12877-019-1053-yDOI Listing
February 2019

Etiology of acute otitis media and phenotypic-molecular characterization of Streptococcus pneumoniae isolated from children in Liuzhou, China.

BMC Infect Dis 2019 Feb 15;19(1):168. Epub 2019 Feb 15.

Children's Hospital of Michigan, Detroit, MI, USA.

Background: The etiology and epidemiology of acute otitis media (AOM) are poorly understood in China. This study aimed to describe the etiology of AOM and the phenotypic and molecular characteristics of AOM-causing Streptococcus pneumoniae (S.pneumoniae) recovered from Chinese children. Read More

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http://dx.doi.org/10.1186/s12879-019-3795-8DOI Listing
February 2019

The Renew Anal Insert for Passive Faecal Incontinence: a retrospective audit of our use of a novel device.

Colorectal Dis 2019 Feb 15. Epub 2019 Feb 15.

Sir Alan Parks Physiology Unit, St Mark's Hospital and Academic Institute, London North West University Healthcare NHS Trust, Harrow, UK.

Introduction: The Renew Anal Insert is a recent treatment for patients who suffer from passive faecal incontinence (FI). The aim was to assess the effectiveness of the insert and patient satisfaction.

Method: A retrospective audit of patients who were treated with the Renew Anal Insert was undertaken. Read More

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http://dx.doi.org/10.1111/codi.14587DOI Listing
February 2019

The burden of proof: The process of involving young people in research.

Health Expect 2019 Feb 15. Epub 2019 Feb 15.

Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.

Patient and public involvement in research includes non-academics working with researchers, on activities from consultative tasks, to joint working, and on user-led initiatives. Health and social care funding bodies require involvement in research projects. A current debate focuses on a perceived lack of empirical "proof" to demonstrate the impact of involvement upon the quality of research. Read More

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http://dx.doi.org/10.1111/hex.12870DOI Listing
February 2019

Factors associated with readmission and mortality in adult patients with skin and soft tissue infections.

Int J Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Clinical Microbiology Department, Son Llàtzer Hospital, Balearic Islands, Spain.

Background: Skin and soft tissue infections (SSTIs) are a common cause of consultation, and complicated cases require hospitalization. We describe factors that are related to readmission and/or mortality of hospitalized patients diagnosed with SSTIs.

Methods: Retrospective review of hospital-admitted patients with a diagnosis of cellulitis, abscess, hidradenitis, fasciitis, and Fournier's gangrene. Read More

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http://dx.doi.org/10.1111/ijd.14390DOI Listing
February 2019

Endorsement of the 66/68 joint count for the measurement of musculoskeletal disease activity: OMERACT 2018 Psoriatic Arthritis workshop report.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore University of Leeds, Leeds, UK, and University of Oxford, Oxford, UK Musculoskeletal Health and Outcomes Research, St. Michael's Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto, Toronto, ON, Canada. Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital & Department of Rheumatology, Odense University Hospital, Denmark Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, , Amsterdam, The Netherlands. Department of Medicine, University of Toronto, Women's College Hospital, Toronto, ON, Canada Pfizer Inc., Montreal, QC, Canada Department of Rheumatology, St Vincent's University Hospital and Conway Institute for Biomolecular Research, University College Dublin, Ireland. Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada Patient Research Partner; Division of Rheumatology, Duke University School of Medicine, Durham, NC; Kezar Life Sciences, South San Francisco, CA, USA Division of Rheumatology, Duke University School of Medicine, Durham, NC, USA Royal Prince Alfred Hospital Medical Centre, Sydney, Australia Patient Research Partner, employed by Amgen Inc, Thousand Oaks, CA, USA Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research, Ottawa, ON, Canada Swedish-Providence-St. John's Health Systems and University of Washington, Seattle, WA, USA Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa, ON, Canada Division of Immunology/Rheumatology, Stanford University School of Medicine, Palo Alto, CA, USA St. Vincent's University Hospital and University College Dublin, Dublin, Ireland Royal National Hospital for Rheumatic Diseases and the University of Bath, Bath, UK. Address correspondence to Alexis Ogdie, MD, University of Pennsylvania, White Building Room 5023, 3400 Spruce St, Philadelphia, Pennsylvania 19104, United States. E-mail:

Objective: The psoriatic arthritis (PsA) core domain set for randomized controlled trials (RCTs) and longitudinal observational studies (LOS) has recently been updated. The joint counts are central to the measurement of the peripheral arthritis component of the musculoskeletal (MSK) disease activity domain. We report the Outcome Measures in Rheumatology (OMERACT) 2018 meeting approaches to seek endorsement of the 66/68-swollen and tender joint count (SJC66/TJC68) for inclusion in the PsA Core Outcome Measurement Set. Read More

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http://dx.doi.org/10.3899/jrheum.181089DOI Listing
February 2019

Economic Burden among Commercially Insured Patients with Systemic Sclerosis in the United States.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From the Analysis Group Inc., Boston, Massachusetts; Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut; University of Colorado School of Medicine, Denver, Colorado, USA. This study was funded by Boehringer Ingelheim Pharmaceuticals Inc. Y. Fan is a salaried employee of Boehringer Ingelheim Pharmaceuticals Inc. Z. Zhou, W. Tang, X. Liu, D. Thomason, Z.Y. Zhou, and D. Macaulay are employees of Analysis Group Inc., which has received consultancy fees from Boehringer Ingelheim Pharmaceuticals Inc. Z. Zhou, MS, Analysis Group Inc.; Y. Fan, ScD, Boehringer Ingelheim Pharmaceuticals Inc.; W. Tang, MS, Analysis Group Inc.; X. Liu, MS, Analysis Group Inc.; D. Thomason, MBA, Analysis Group Inc.; Z.Y. Zhou, PhD, Analysis Group Inc.; D. Macaulay, PhD, Analysis Group Inc.; A. Fischer, MD, University of Colorado School of Medicine. Address corresponding to Z. Zhou, 111 Huntington Ave., Boston, Massachusetts 02199-7668, USA. E-mail: Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication October 16, 2018.

Objective: To quantify healthcare resource utilization (HRU), work loss, and annual direct and indirect healthcare costs among patients with systemic sclerosis (SSc) compared to matched controls in the United States.

Methods: Data were obtained from a large US commercial claims database. Patients were ≥ 18 years old at the index date (first SSc diagnosis) and had ≥ 1 SSc diagnosis in the inpatient (IP) or emergency room (ER) setting, or ≥ 2 SSc diagnoses on 2 different dates in the outpatient (OP) setting between January 1, 2005, and March 31, 2015; continuous enrollment was required during the followup period (12 months after the index date). Read More

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http://dx.doi.org/10.3899/jrheum.180445DOI Listing
February 2019

A Tale of Two Sterilizers.

Authors:
James P Agalloco

PDA J Pharm Sci Technol 2019 Feb 15. Epub 2019 Feb 15.

Agalloco & Associates Inc.

Steam sterilization is widely used across the healthcare industry, and among the most documented and standardized. Despite its broad application, there is considerable confusion regarding the different process control consideration and sterilizer designs necessary for its successful use. The methods and equipment used for porous (equipment, components and tools) loads are established to address air removal and steam penetration as these are critical to process efficacy. Read More

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http://dx.doi.org/10.5731/pdajpst.2019.009993DOI Listing
February 2019

Open-label trial of anterior limb of internal capsule-nucleus accumbens deep brain stimulation for obsessive-compulsive disorder: insights gained.

J Neurol Neurosurg Psychiatry 2019 Feb 15. Epub 2019 Feb 15.

Department of Psychiatry and Psychotherapy, University Hospital of Cologne, Cologne, Germany.

Background: For more than 15 years, deep brain stimulation (DBS) has served as a last-resort treatment for severe treatment-resistant obsessive-compulsive disorder (OCD).

Methods: From 2010 to 2016, 20 patients with OCD (10 men/10 women) were included in a single-centre trial with a naturalistic open-label design over 1 year to evaluate the effects of DBS in the anterior limb of the internal capsule and nucleus accumbens region (ALIC-NAcc) on OCD symptoms, executive functions, and personality traits.

Results: ALIC-NAcc-DBS significantly decreased OCD symptoms (mean Yale-Brown Obsessive Compulsive Scale reduction 33%, 40% full responders) and improves global functioning without loss of efficacy over 1 year. Read More

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http://dx.doi.org/10.1136/jnnp-2018-318996DOI Listing
February 2019

Lifestyle changes may be more important than drugs for mild hypertension.

BMJ 2019 Feb 15;364:l571. Epub 2019 Feb 15.

Bazian, Economist Intelligence Unit healthcare, London, UK.

The studySheppard JP, Stevens S, Stevens R, Martin U, Mant J, Hobbs R, McManus R. Benefits and harms of antihypertensive treatment in low-risk patients with mild hypertension.Published on 1 December 2018 2018;178:1626-34. Read More

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http://dx.doi.org/10.1136/bmj.l571DOI Listing
February 2019

Obesity is strongly and independently associated with a higher prevalence of pulmonary embolism.

Respir Investig 2019 Feb 12. Epub 2019 Feb 12.

Long Beach VA Health Care System, Long Beach, CA, USA. Electronic address:

Background: Obesity is associated with many cardiovascular risk factors. This study aimed to evaluate the independent association between obesity and pulmonary embolism.

Methods: We used the International Classification of Diseases, Ninth Revision, Codes for obesity and pulmonary embolism from the Nationwide Inpatient Sample database. Read More

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http://dx.doi.org/10.1016/j.resinv.2019.01.003DOI Listing
February 2019

Economic evaluation of a publicly funded hepatitis A travel vaccination program in Ontario, Canada.

Vaccine 2019 Feb 12. Epub 2019 Feb 12.

School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario M5T 1P8, Canada; Toronto Health Economics and Technology Assessment (THETA) Collaborative, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada; Public Health Ontario, 480 University Avenue, Toronto, Ontario M5G 1V2, Canada; Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada.

Background: Hepatitis A virus (HAV) causes acute liver infection and is spread through the fecal-oral route. Travel to countries in HAV-endemic regions (e.g. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.01.070DOI Listing
February 2019

Vertical stiffness during one-legged hopping with and without using a running-specific prosthesis.

J Biomech 2019 Feb 1. Epub 2019 Feb 1.

German Sport University Cologne, Cologne, Germany; ARCUS Clinics Pforzheim, Pforzheim, Germany.

Although athletes with unilateral below-the-knee amputations (BKAs) generally use their affected leg, including their prosthesis, as their take-off leg for the long jump, little is known about the spring-like leg behavior and stiffness regulation of the affected leg. The purpose of this study was to investigate vertical stiffness during one-legged hopping in an elite-level long jump athlete with a unilateral BKA. We used the spring-mass model to calculate vertical stiffness, which equals the ratio of maximum vertical ground reaction force to maximum center of mass displacement, while the athlete with a BKA hopped on one leg at a range of frequencies. Read More

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http://dx.doi.org/10.1016/j.jbiomech.2019.01.034DOI Listing
February 2019

Time-driven activity-based costing to model the utility of parallel induction redesign in high-turnover operating lists.

Healthc (Amst) 2019 Feb 12. Epub 2019 Feb 12.

Department of Anaesthetics, Perioperative and Pain Medicine, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, Victoria 3000, Australia; University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia. Electronic address:

Background: Value-based healthcare is strongly advocated to reduce the spiralling rise in healthcare expenditure. Operating room efficiency is an important focus of value-based healthcare delivery due to high costs and associated hospital revenue derived from procedural streams of care. A parallel induction design, utilising induction rooms for anesthetising patients, may improve operating room efficiency and optimise revenue. Read More

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http://dx.doi.org/10.1016/j.hjdsi.2019.01.003DOI Listing
February 2019

Opioid Use Disorder and Its Treatment Among Older Adults: An Invited Commentary.

Authors:
Patience Moyo

Am J Geriatr Psychiatry 2019 Jan 17. Epub 2019 Jan 17.

Department of Health Services, Policy, and Practice (PM), Center for Gerontology and Healthcare Research, Brown University School of Public Health, Providence, RI. Electronic address:

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http://dx.doi.org/10.1016/j.jagp.2019.01.009DOI Listing
January 2019

Effect of a social support program for mothers of children with precocious puberty: A preliminary quasi-experimental study.

J Pediatr Nurs 2019 Feb 12. Epub 2019 Feb 12.

Department of Nursing, Dong-A University, Busan, Republic of Korea. Electronic address:

Purpose: The purpose of this study was to evaluate the effects of a social support program on the stress, anxiety, guilt, and life satisfaction levels among Korean mothers of children with precocious puberty.

Design And Methods: A non-equivalent control group and a non-synchronized design were used in this quasi-experiment study. Thirty-four mothers (divided into equal-sized experimental and control groups), 32-47 years of age, with children aged 6-11 years old, were recruited from a pediatric outpatient department at a national university hospital. Read More

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http://dx.doi.org/10.1016/j.pedn.2019.01.012DOI Listing
February 2019

Surgical Technique for Complex Cases of Peyronie's Disease With Implantation of Penile Prosthesis, Multiple Corporeal Incisions, and Grafting With Collagen Fleece.

J Sex Med 2019 Feb;16(2):323-332

Urology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Universidad Autónoma de Madrid, Madrid, Spain. Electronic address:

Introduction: Patients with Peyronie's disease (PD) and erectile dysfunction (ED) concomitant with shortening or other malformations benefit from prosthesis implantation and penile lengthening procedures.

Aim: To evaluate the safety and efficacy of a multi-incisional technique with penile prosthesis implantation with multiple corporeal incisions and collagen grafting for the surgical management of complex cases of PD with ED and severe penile shortening.

Methods: From February 2015-May 2018, 43 consecutive patients with complex PD were treated using this technique. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.11.014DOI Listing
February 2019

Epidemiology of Penile Fractures in United States Emergency Departments: Access to Care Disparities May Lead to Suboptimal Outcomes.

J Sex Med 2019 Feb;16(2):248-256

Boston Medical Center, Boston, MA, USA. Electronic address:

Introduction: The epidemiology of penile fractures in the emergency setting is not well described.

Aim: Examine the incidence, evaluation, management, risk factors predicting surgical repair or hospital transfer, and use of financial resources in patients presenting with penile fractures to the emergency departments (ED) nationwide in the Unites States.

Methods: ED visits with a primary diagnosis of penile fractures (International Classification of Diseases, Ninth Edition codes) between 2010-2014 were abstracted from the Nationwide Emergency Department Sample. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.12.009DOI Listing
February 2019

Renal perfusion, oxygenation, and sympathetic nerve activity during volatile or intravenous general anaesthesia in sheep.

Br J Anaesth 2019 Mar 11;122(3):342-349. Epub 2019 Jan 11.

Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia. Electronic address:

Background: Global and intra-renal perfusion and oxygenation may be affected by the choice of anaesthetic. We compared the effects of isoflurane with those of propofol and fentanyl on renal blood flow (RBF) and intra-renal perfusion and oxygenation, and assessed how these were associated with renal sympathetic nerve activity (RSNA).

Methods: A renal artery flow probe and laser Doppler and oxygen-sensing probes were surgically implanted in the renal medulla and cortex in 20 Merino ewes. Read More

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http://dx.doi.org/10.1016/j.bja.2018.11.018DOI Listing

Effectiveness of 80% vs 30-35% fraction of inspired oxygen in patients undergoing surgery: an updated systematic review and meta-analysis.

Br J Anaesth 2019 Mar 6;122(3):325-334. Epub 2019 Jan 6.

Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Background: In 2016, the World Health Organization (WHO) strongly recommended the use of a high fraction of inspired oxygen (FiO) in adult patients undergoing general anaesthesia to reduce the risk of surgical site infection (SSI). Since then, further trials have been published, trials included previously have come under scrutiny, and one article was retracted. We updated the systematic review on which the recommendation was based. Read More

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http://dx.doi.org/10.1016/j.bja.2018.11.024DOI Listing

Safety of 80% vs 30-35% fraction of inspired oxygen in patients undergoing surgery: a systematic review and meta-analysis.

Br J Anaesth 2019 Mar 3;122(3):311-324. Epub 2019 Jan 3.

Norwich Medical School, University of East Anglia, Norwich, UK.

Background: Evidence-based guidelines from the World Health Organization (WHO) have recommended a high (80%) fraction of inspired oxygen (FiO) to reduce surgical site infection in adult surgical patients undergoing general anaesthesia with tracheal intubation. However, there is ongoing debate over the safety of high FiO. We performed a systematic review to define the relative risk of clinically relevant adverse events (AE) associated with high FiO. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00070912183135
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http://dx.doi.org/10.1016/j.bja.2018.11.026DOI Listing
March 2019
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"Wounds Home Alone"-Why and How Venous Leg Ulcer Patients Self-Treat Their Ulcer: A Qualitative Content Study.

Int J Environ Res Public Health 2019 Feb 15;16(4). Epub 2019 Feb 15.

Polyclinic Marija, Kneza Mislava 2, Zagreb 10000, Croatia.

Background: Venous leg ulcers (VLUs), the most common type of leg ulcerations, have long healing times and high recurrence rates; reimbursement rules and a general shortage of nursing staff have put self-treatment into focus. The study aimed to investigate why and how patients with VLUs self-treat their ulcers.

Methods: Patients with VLUs ( = 32) were selected by criterion sampling for a multicentric qualitative study using semi-structured interviews. Read More

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http://dx.doi.org/10.3390/ijerph16040559DOI Listing
February 2019

Comparing the Convergent and Concurrent Validity of the Dynamic Gait Index with the Berg Balance Scale in People with Multiple Sclerosis.

Healthcare (Basel) 2019 Feb 15;7(1). Epub 2019 Feb 15.

UAB/Lakeshore Research Collaborative; School of Health Professions, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Recent clinical guidelines for adults with neurological disabilities suggest the need to assess measures of static and dynamic balance using the Berg Balance Scale (BBS) and Dynamic Gait Index (DGI) as core outcome measures. Given that the BBS measures both static and dynamic balance, it was unclear as to whether either of these instruments was superior in terms of its convergent and concurrent validity, and whether there was value in complementing the BBS with the DGI. : The objective was to evaluate the concurrent and convergent validity of the BBS and DGI by comparing the performance of these two functional balance tests in people with multiple sclerosis (MS). Read More

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http://dx.doi.org/10.3390/healthcare7010027DOI Listing
February 2019

Outpatient Cancer Care Delivery in the Context of E-Oncology: A French Perspective on "Cancer outside the Hospital Walls".

Cancers (Basel) 2019 Feb 14;11(2). Epub 2019 Feb 14.

Aix-Marseille Univ, INSERM U1068, CNRS UMR7258, Département d'Oncologie Médicale, Institut Paoli-Calmettes, CRCM, 13009 Marseille, France.

In oncology, the treatment of patients outside of hospitals has become imperative due to an increasing number of patients who are older and live longer, along with issues such as medical desertification, oncologist hyperspecialization, and difficulties in financing mounting health expenditures. Treatments have become less "invasive", with greater precision and efficiency. Patients can therefore receive most of their care outside of hospitals. Read More

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http://dx.doi.org/10.3390/cancers11020219DOI Listing
February 2019

[Dopamine Transporter SPECT with I-123 labelled FP-CIT (DaTSCANTM)].

Nuklearmedizin 2019 Feb 15;58(1):5-16. Epub 2019 Feb 15.

Universitätsklinikum Freiburg, Klinik für Nuklearmedizin.

The aim of the S1 guideline is to assist in establishing the indication and in performing, interpreting and reporting SPECT investigations of the dopamine transporter (DAT) with DaTSCAN. Compared to the preceding version dated from 2007 the current update considers relevant new publications, the guidelines of the European (EANM) and Society of Nuclear Medicine (SNM), and the current version of the S3 guideline of the German Society of Neurology on "Idiopathic Parkinsonsian Syndrome". In addition new technical developments are incorporated. Read More

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http://dx.doi.org/10.1055/a-0807-8137DOI Listing
February 2019

[Violence in the Emergency Medicine (Emergency Rescue Service and Emergency Departments) - Current Situation in Germany].

Anasthesiol Intensivmed Notfallmed Schmerzther 2019 Feb 15;54(2):146-154. Epub 2019 Feb 15.

Background: During the last years healthcare personnel is more often faced with different degrees of violence and aggression while doing their jobs. However, systematic data with respect to offender profiles, reasons, frequency and types of violence in emergency medicine in Germany has not been systematically analyzed.

Aim: The aim of this article is to overview the data of present German studies. Read More

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http://dx.doi.org/10.1055/s-0043-112189DOI Listing
February 2019
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