1,257,036 results match your criteria Healthcare informatics : the business magazine for information and communication systems[Journal]


Impact of Deployment on Reproductive Health in U.S. Active-Duty Servicewomen and Veterans.

Semin Reprod Med 2018 Nov 19;36(6):361-370. Epub 2019 Apr 19.

Informatics, Decision Enhancement, and Analytic Sciences (IDEAS) Center, VA Salt Lake City Health Care System, Salt Lake City, Utah.

Reproductive-age women are a fast-growing component of active-duty military personnel who experience deployment and combat more frequently than previous service-era women Veterans. With the expansion of the number of women and their roles, the United States Departments of Defense and Veterans Affairs have prioritized development and integration of reproductive services into their health systems. Thus, understanding associations between deployments or combat exposures and short- or long-term adverse reproductive health outcomes is imperative for policy and programmatic development. Read More

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http://dx.doi.org/10.1055/s-0039-1678749DOI Listing
November 2018

Preconception Care in the Veterans Health Administration.

Semin Reprod Med 2018 Nov 19;36(6):327-339. Epub 2019 Apr 19.

VA Central Office, Women's Health Services, Washington, District of Columbia.

Preconception care (PCC), defined as a set of interventions to help women optimize their health and well-being prior to pregnancy, can improve pregnancy outcomes and is recommended by national organizations including the Centers for Disease Control and Prevention and the American College of Obstetricians and Gynecologists. Women Veterans who use the Department of Veterans Affairs (VA) health care system may face elevated risks of adverse pregnancy and birth outcomes due to a high prevalence of chronic medical and mental health conditions as well as psychosocial stressors including sexual trauma history and intimate partner violence. Many women Veterans of childbearing age experience poverty and homelessness, which are key social determinants of poor reproductive health outcomes. Read More

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http://dx.doi.org/10.1055/s-0039-1678753DOI Listing
November 2018

Reproductive Health of Women Veterans: A Systematic Review of the Literature from 2008 to 2017.

Semin Reprod Med 2018 Nov 19;36(6):315-322. Epub 2019 Apr 19.

Division of Gynecology, Department of Surgery, VA Boston Healthcare System, Boston, Massachusetts.

The literature on the reproductive health and healthcare of women Veterans has increased dramatically, though there are important gaps. This article aims to synthesize recent literature on reproductive health and healthcare of women Veterans. We updated a literature search to identify manuscripts published between 2008 and July 1, 2017. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678750
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http://dx.doi.org/10.1055/s-0039-1678750DOI Listing
November 2018
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Sick of retirement?

J Health Econ 2019 Apr 1;65:133-152. Epub 2019 Apr 1.

Department of Economics, University of Copenhagen and Center for Economic Behavior and Inequality (CEBI), Denmark. Electronic address:

This paper examines the causal effect of retirement on health and healthcare utilization using two identification strategies on Danish full population data. First, I use a reform of the statutory retirement age in an IV design. Second, I use a large discontinuity in retirement take-up at the earliest age of retirement (60) in a regression discontinuity design. Read More

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http://dx.doi.org/10.1016/j.jhealeco.2019.03.008DOI Listing

Muscarinic activity in hippocampus and entorhinal cortex is crucial for spatial and fear memory retrieval.

Pharmacol Rep 2019 Feb 8;71(3):449-456. Epub 2019 Feb 8.

Neurobiology Laboratory, Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan. Electronic address:

Background: Hippocampus and entorhinal cortex are key players of learning and memory. Despite their established role in memory processes, the contribution of muscarinic receptor activity in these brain regions during memory retrieval remains elusive. This study was aimed to assess the role of hippocampal CA1 and medial entorhinal cortex muscarinic receptors in memory retrieval. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.02.004DOI Listing
February 2019

Moderate hearing loss is related with social frailty in a community-dwelling older adults: The Korean Frailty and Aging Cohort Study (KFACS).

Arch Gerontol Geriatr 2019 Apr 12;83:126-130. Epub 2019 Apr 12.

Department of Family Medicine, Kyung Hee University Medical Center, kyungheedaero 23, dongdaemun-gu, 02447, Seoul, Republic of Korea; Elderly Frailty Research Center, Department of Family Medicine, Kyung Hee University College of Medicine, kyungheedaero 23, dongdaemun-gu, 02447, Seoul, Republic of Korea. Electronic address:

Objectives: To determine whether hearing loss is associated with social frailty in older adults.

Methods: Cross-sectional analysis of cohort study data. Hearing was measured using of Pure-tone audiometry. Read More

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http://dx.doi.org/10.1016/j.archger.2019.04.004DOI Listing

Commercial kitchenware glass as a potential thermoluminescent media for retrospective dosimetry.

Appl Radiat Isot 2019 Apr 7;148:218-224. Epub 2019 Apr 7.

Centre for Biomedical Physics, School of Healthcare and Medical Sciences, Sunway University, 47500, Bandar Sunway, Selangor, Malaysia; Department of Physics, University of Surrey, Guildford, Surrey, GU2 7XH, UK.

Study has been made of the thermoluminescence (TL) yield of various glass-based commercial kitchenware (Reko-China, Skoja-France, Godis-China, Glass Tum-Malaysia, Lodrat-France). Interest focuses on their potential for retrospective dosimetry. Use was made of aCo gamma-ray irradiator, delivering doses in the range 2-10 Gy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09698043183121
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http://dx.doi.org/10.1016/j.apradiso.2019.04.001DOI Listing
April 2019
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Allogeneic stem cell transplantation for acute lymphoblastic leukemia in adolescents and young adults.

Biol Blood Marrow Transplant 2019 Apr 16. Epub 2019 Apr 16.

Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan; Department of Pediatric Hematology and Oncology Research, National Center for Child Health and Development, Tokyo, Japan.

Hematologic stem cell transplantation (HSCT) is the most potent consolidation therapy for high-risk acute lymphoblastic leukemia (ALL), but their outcomes and complications in adolescent and young adult (AYA) patients are still unclear. We compared outcomes after HSCT for ALL among children (1 to 9 years old, n = 607), adolescents (10 to 19 years old, n= 783) and young adults (20 to 29 years old, n = 603), based on nationwide registry data in Japan. The overall survival rate among AYA patients was worse than that of children; survival rate at 5 years among AYA patients was 64% (95% confidence intervals [CI], 60% to 68%). Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.04.014DOI Listing

Worldwide Network for Blood and Marrow Transplantation (WBMT) recommendations for establishing a hematopoietic stem cell transplantation program in countries with limited resources (Part II): clinical, technical and socio-economic considerations.

Biol Blood Marrow Transplant 2019 Apr 16. Epub 2019 Apr 16.

Center for Hematopoietic Stem Cell Transplantation, Aichi Medical University Hospital, Nagakute; Department of Hematology and Medical Oncology, University Hospital, Leipzig, Germany.

The development of hematopoietic stem cell transplantation (HSCT) programs can face significant challenges in most developing countries because such endeavors must compete with other government health care priorities, including the delivery of basic services. While this is may be a limiting factor, these countries should prioritize development of the needed expertise to offer state of the art treatments including transplantation, by providing financial, technological, legal, ethical and other needed support. This would prove beneficial in providing successful programs customized to the needs of their population, and potentially provide long-term cost-savings by circumventing the need for their citizens to seek care abroad. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.04.012DOI Listing

Safety-Engineered Syringes: An Intervention to Decrease Hepatitis C Burden in Developing Countries-A Cost-Effectiveness Analysis from Egypt.

Value Health Reg Issues 2019 Apr 16;19:51-58. Epub 2019 Apr 16.

HTA Office, L.L.C., Cairo, Egypt; Pharmacy Practice Department, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt. Electronic address:

Introduction: To assess the cost-effectiveness of introducing the safety-engineered syringe (SES) to decrease hepatitis C burden resultant from unsafe injection practices in healthcare settings.

Methods: A Markov process model for a hypothetical study cohort was developed over a 30-year time horizon to compare the adoption of SES use with the current strategy, conventional syringes (CS), in the Egyptian healthcare settings. The national treatment program was applied in both groups. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22121099193003
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http://dx.doi.org/10.1016/j.vhri.2018.11.009DOI Listing
April 2019
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A systematic review of the word sentence association paradigm (WSAP).

J Behav Ther Exp Psychiatry 2019 Apr 11;64:133-148. Epub 2019 Apr 11.

Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, United States; McLean Hospital/Harvard Medical School, United States. Electronic address:

Background And Objectives: The Word Sentence Association Paradigm (WSAP) was originally designed to assess and modify interpretive biases (IB) in socially anxious individuals. Researchers have since modified the WSAP for use across various populations. Despite its widespread use, no studies have systematically reviewed the WSAP to determine its validity and reliability. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00057916183017
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http://dx.doi.org/10.1016/j.jbtep.2019.04.003DOI Listing
April 2019
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Inner speech is accompanied by a temporally-precise and content-specific corollary discharge.

Neuroimage 2019 Apr 16. Epub 2019 Apr 16.

School of Psychology, UNSW Sydney, Sydney, Australia.

When we move our articulator organs to produce overt speech, the brain generates a corollary discharge that acts to suppress the neural and perceptual responses to our speech sounds. Recent research suggests that inner speech - the silent production of words in one's mind - is also accompanied by a corollary discharge. Here, we show that this corollary discharge contains information about the temporal and physical properties of inner speech. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.04.038DOI Listing

The new US and European guidelines in hypertension: A multi-dimensional analysis.

Contemp Clin Trials 2019 Apr 16. Epub 2019 Apr 16.

Medbase, Chapel Hill, NC, USA.

The Systolic Blood Pressure Intervention Trial (SPRINT) compared the clinical outcomes between target systolic blood pressure (SBP) levels between 140 and 120 mmHg or lower. Both,the 2017 ACC/AHA and the 2018 ESC/ESH guidelines in hypertension are derived from the SPRINT trial and advise initiation and/or intensification of treatment at lower blood pressure thresholds. The ACC/AHA guidance supersedes the 2014 Eight Joint National Committee guideline (JNC-8) which advised initiation of treatment when the BP was 140/90 mmHg or higher; in adults 60 years or over, the target was 150/90 mmHg. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15517144183071
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http://dx.doi.org/10.1016/j.cct.2019.04.008DOI Listing
April 2019
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"I was considering surgery because I believed that was how it was treated": A qualitative study on willingness for joint surgery after completion of a digital management program for osteoarthritis.

Osteoarthritis Cartilage 2019 Apr 16. Epub 2019 Apr 16.

Department of Health Sciences, Lund University, Lund, Sweden; The PRO-CARE Group, School of Health and Society, Kristianstad University, Kristianstad, Sweden.

Objective: To explore, using a qualitative approach, reasons for patients' continued willingness or their shift in willingness for total joint replacement (TJR) surgery, following participation in Joint Academy, a Swedish, digital, non-surgical treatment program for osteoarthritis (OA).

Design: Nineteen patients with hip or knee OA were interviewed after finishing their first six weeks in the treatment program, using a semi-structured interview guide. The interviews were transcribed verbatim and analyzed using a systematic text condensation method. Read More

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http://dx.doi.org/10.1016/j.joca.2019.04.004DOI Listing

Competencies on environmental health and pedagogical approaches in the nursing curriculum: A systematic review of the literature.

Nurse Educ Pract 2019 Apr 5;37:1-8. Epub 2019 Apr 5.

Health Service Research, Faculty of Health and Human Sciences, Plymouth University, Drake Circus, Plymouth PL4 8AA, UK. Electronic address:

It has been suggested that climate change is the biggest threat to public health for the 21st Century; increased demand on health services will impact on already overstretched resources and systems will need to be able to respond. However limited attention is given to climate change and sustainability in nursing education; there is no clear guidance on curricula content for nurses or recommendations regarding the skills and competencies that will be required. Literature published in Dutch, English, German, and Spanish was searched and 32 papers met the inclusion criteria for the review. Read More

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http://dx.doi.org/10.1016/j.nepr.2019.04.004DOI Listing

Vacuum Induced Surface Freezing for the Freeze-Drying of the Human Growth Hormone: How does Nucleation Control Affect Protein Stability?

J Pharm Sci 2019 Apr 16. Epub 2019 Apr 16.

Standardisation Science, National Institute for Biological Standards and Control, Blanche Lane, Medicines & Healthcare products Agency, South Mimms, Potters Bar, Hertfordshire, EN6 3QG, UK. Electronic address:

In the present work, the effect of controlled nucleation on the stability of human growth hormone (hGH) during freeze-drying has been investigated. More specifically, the vacuum induced surface freezing technique has been compared to conventional freezing, both with and without an annealing step. Size exclusion chromatography and cell-based potency assays have been used to characterize the formation of soluble aggregates and the biological activity of hGH, respectively. Read More

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http://dx.doi.org/10.1016/j.xphs.2019.04.014DOI Listing

Pharmacokinetics and tissue distribution of pilocarpine after eyelid skin application to rats.

J Pharm Sci 2019 Apr 16. Epub 2019 Apr 16.

Graduate School of Pharmaceutical Sciences; Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Saitama, Japan. Electronic address:

Extending the delivery of drugs into the eyes while reducing systemic bioavailability is of utmost importance in the management of chronic ocular diseases. Topical application onto the lower eyelid skin, as an alternative to eye drops, is seen to be a valuable strategy in the treatment of chronic eye diseases. To elucidate the critical value of delivering drugs in solution onto the eyeball through the eyelid skin, pharmacokinetic studies of pilocarpine were conducted, and the results were verified using a direct pharmacodynamic study in rats. Read More

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http://dx.doi.org/10.1016/j.xphs.2019.04.012DOI Listing

Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood.

Cell 2019 Apr;177(3):587-596.e9

Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

Severe obesity is a rapidly growing global health threat. Although often attributed to unhealthy lifestyle choices or environmental factors, obesity is known to be heritable and highly polygenic; the majority of inherited susceptibility is related to the cumulative effect of many common DNA variants. Here we derive and validate a new polygenic predictor comprised of 2. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193029
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http://dx.doi.org/10.1016/j.cell.2019.03.028DOI Listing
April 2019
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Abortion Providers' experiences and views on self-managed medication abortion, an exploratory study.

Contraception 2019 Apr 16. Epub 2019 Apr 16.

University of Iowa Hospitals and Clinics, Department of Obstetrics and Gynecology, 200 Hawkins Drive, Iowa City, IA, 52242.

Objective: Data on the practice of self-managed medication abortion are limited, in part because this practice takes place purposefully outside of established healthcare systems. Given this, we aimed to ascertain abortion providers' familiarity with self-managed medication abortion and associated complications, compare regional differences, and evaluate provider attitudes.

Study Design: We distributed an online survey to members of Society for Family Planning, Association of Reproductive Health Providers, and the Abortion Care Network between July and September 2017 querying experiences with and opinions about self-managed abortion. Read More

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http://dx.doi.org/10.1016/j.contraception.2019.04.006DOI Listing
April 2019
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Direct Detection of Tissue-Resident Bacteria and Chronic Inflammation in the Bladder Wall of Postmenopausal Women with Recurrent Urinary Tract Infection.

J Mol Biol 2019 Apr 16. Epub 2019 Apr 16.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, United States of America; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, United States of America; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, United States of America. Electronic address:

Urinary tract infections (UTIs) are the most commonly reported infections in adult women and have high rates of recurrence, especially in postmenopausal women. Recurrent UTI (RUTI) greatly reduces quality of life, places a significant burden on the healthcare system, and contributes to antimicrobial resistance. Because treatment of RUTI by long-term antibiotic therapy is often ineffective or poorly tolerated in elderly women, new therapies must be developed. Read More

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http://dx.doi.org/10.1016/j.jmb.2019.04.008DOI Listing

SMFM Special Statement: State of the Science on Multifetal Gestations: Unique Considerations and Importance.

Am J Obstet Gynecol 2019 Apr 16. Epub 2019 Apr 16.

Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, United States.

We sought to review the state of the science for research on multiple gestations. A literature search was performed using PubMed to quantify the representation of multiple gestations for a sample period (2012-2016) limited to Phase III and IV randomized controlled trials and written in English addressing at least one of four major pregnancy complications for illustration: fetal growth restriction or small-for-gestational-age fetus, gestational diabetes, preeclampsia, and preterm delivery. Of the 226 studies included in the analysis, multiple pregnancies were most represented in studies of preterm delivery: 17% of trials recruited both singleton and multiple pregnancies, and another 18% of trials recruited only multiple pregnancies. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.04.013DOI Listing

Intermittent hypoxia impairs uterine artery function in pregnant mice.

J Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.

Key Points: Obstructive sleep apnoea (OSA) is a chronic condition characterized by intermittent hypoxia that induces oxidative stress and inflammation leading to cardiovascular disease. Women can develop OSA during late pregnancy, which is associated with adverse maternal and fetal outcomes. However, the effects of OSA throughout pregnancy on fetoplacental outcomes are unknown. Read More

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http://dx.doi.org/10.1113/JP277775DOI Listing

From crisis to self-confidence and adaptation; Experiences of being a parent of a child with VACTERL association - A complex congenital malformation.

PLoS One 2019 19;14(4):e0215751. Epub 2019 Apr 19.

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

Aim: Knowledge is scarce regarding mothers' and fathers' experiences of being a parent of a child with VACTERL association-a complex malformation. The aim of the study was to describe experiences of being a parent of a child with VACTERL association.

Method: Semi-structured interviews were performed with ten mothers and nine fathers face-to-face or by telephone and analyzed by using Qualitative content analysis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215751PLOS
April 2019
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Correlates of continuum of maternal health services among Nepalese women: Evidence from Nepal Multiple Indicator Cluster Survey.

PLoS One 2019 19;14(4):e0215613. Epub 2019 Apr 19.

Research Unit of General Practice, Department of Public Health, University of Southern Denmark, Odense, Denmark.

Continuum of Care (CoC) is an essential strategy to prevent maternal and child deaths where health services are arranged in a pathway throughout pregnancy, childbirth and after delivery. However, CoC is still a challenge in Nepal. This study aimed to investigate the correlates of CoC from pregnancy to the postnatal period in Nepalese women aged 15 to 49 years. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215613PLOS

Prevalence and predictors for sustained remission in rheumatoid arthritis.

PLoS One 2019 19;14(4):e0214981. Epub 2019 Apr 19.

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea.

Objective: Remission is a key goal in managing rheumatoid arthritis (RA), with sustained remission as the preferred sequelae of short-term remission. However little is known about the predictors of sustained remission for patients reaching remission. Using two independent cohorts, we aimed to evaluate the prevalence and predictors for sustained remission. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214981PLOS

The World after Ebola: An Overview of Ebola Complications, Vaccine Development, Lessons Learned, Financial Losses, and Disease Preparedness.

Crit Rev Eukaryot Gene Expr 2019 ;29(1):77-84

Foundation University Medical College, Foundation University Islamabad, DHA-I Islamabad (44000), Pakistan.

The 2014-2016 Ebola outbreak in West Africa was the largest of its kind with 11,000 deaths and approximately 28,637 affected cases. The aim of the study was to analyze the global situation after the Ebola outbreak including Ebola complications, vaccine development, lessons learned, financial losses, and disease preparedness. We searched in PubMed, Google, and Google Scholar by using keywords Ebola virus, Ebola vaccine development and Ebola virus transmission, the world after Ebola, financial losses by Ebola outbreak, and disease preparedness. Read More

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http://dx.doi.org/10.1615/CritRevEukaryotGeneExpr.2019025175DOI Listing
January 2019

Enhancing Understanding of Moral Distress: The Measure of Moral Distress for Health Care Professionals.

AJOB Empir Bioeth 2019 Apr 19:1-12. Epub 2019 Apr 19.

e School of Nursing , Virginia Commonwealth University , Richmond , Virginia , USA.

Background: As ongoing research explores the impact of moral distress on health care professionals (HCPs) and organizations and seeks to develop effective interventions, valid and reliable instruments to measure moral distress are needed. This article describes the development and testing of a revision of the widely used Moral Distress Scale-Revised (MDS-R) to measure moral distress.

Methods: We revised the MDS-R by evaluating the combined data from 22 previous studies, assessing 301 write-in items and 209 root causes identified through moral distress consultation, and reviewing 14 recent publications from various professions in which root causes were described. Read More

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http://dx.doi.org/10.1080/23294515.2019.1586008DOI Listing

Alternatives to (antipsychotic) medication in people with dementia.

Authors:
Aysha Mendes

Br J Nurs 2019 Apr;28(8):534

Freelance Journalist, specialising in healthcare, psychology and nursing.

, Freelance Journalist, specialising in healthcare, psychology and nursing, looks at ways of caring for people with dementia without the use of antipsychotic drugs. Read More

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http://dx.doi.org/10.12968/bjon.2019.28.8.534DOI Listing
April 2019
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Vascular access nurse of the year 2019: runners up.

Br J Nurs 2019 Apr;28(8):S14

Clinical Nurse Specialists for Intravenous Therapy, Hounslow and Richmond Community Healthcare NHS Trust.

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http://www.magonlinelibrary.com/doi/10.12968/bjon.2019.28.8.
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http://dx.doi.org/10.12968/bjon.2019.28.8.S14DOI Listing
April 2019
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Pediatric drug safety signal detection of non-chemotherapy drug-induced neutropenia and agranulocytosis using electronic healthcare records.

Expert Opin Drug Saf 2019 Apr 19:1-7. Epub 2019 Apr 19.

a Clinical Research Center , National Center for Children's Health, Beijing Children's Hospital, Capital Medical University , Beijing , China.

Objectives: This study aimed to develop a procedure to explore the adverse drug reaction signals of drug-induced neutropenia (DIN) or drug-induced agranulocytosis (DIA) in children using an electronic health records (EHRs) database.

Methods: A two-stage design was presented. First, the suspected drugs to induce DIN or DIA were selected. Read More

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http://dx.doi.org/10.1080/14740338.2019.1604682DOI Listing

Managing costs and care for chronic idiopathic constipation.

Authors:
Dana McCormick

Am J Manag Care 2019 Mar;25(4 Suppl):S63-S69

Director of Pharmacy, Blue Cross Blue Shield of Texas, Richardson, TX. Email:

For decades, chronic idiopathic constipation (CIC) has been one of the most common chronic functional gastrointestinal disorders encountered by clinicians. Common comorbidities include depression, diabetes, functional dyspepsia, hypothyroidism, overweight, obesity, and neurological disorders. CIC imposes a large economic burden on the American healthcare system with estimated costs of $1912 to $7522 in 2007 US dollars per patient per year. Read More

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March 2019
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Update on the management of chronic idiopathic constipation.

Authors:
Brian E Lacy

Am J Manag Care 2019 Mar;25(4 Suppl):S55-S62

Senior Associate Consultant, Mayo Clinic, Jacksonville, FL. Email:

Chronic idiopathic constipation is a functional bowel disorder characterized by difficult, infrequent, and/or incomplete defecation, affecting 35 million adult Americans, resulting in more than millions of physician visits annually. Symptoms of constipation vary from patient to patient and impact all age groups and patient populations in the United States. The definition of constipation was previously not well specified, beyond stool frequency, and has been revised to incorporate the patient perspective and experience in addition to specific criteria created by the Rome Foundation. Read More

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Newly defined ABCB5 dermal mesenchymal stem cells promote healing of chronic iron overload wounds via secretion of interleukin-1 receptor antagonist.

Stem Cells 2019 Apr 19. Epub 2019 Apr 19.

Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany.

Here we report the beneficial effects of a newly identified dermal cell subpopulation expressing the ATP-binding cassette subfamily B member 5 (ABCB5) for the therapy of non-healing wounds. Local administration of dermal ABCB5 -derived MSCs attenuated macrophage-dominated inflammation and thereby accelerated healing of full-thickness excisional wounds in the iron overload mouse model mimicking the non-healing state of human venous leg ulcers. The observed beneficial effects were due to interleukin-1 receptor antagonist (IL-1RA) secreted by ABCB5 -derived MSCs, which dampened inflammation and shifted the prevalence of unrestrained pro-inflammatory M1 macrophages toward repair promoting anti-inflammatory M2 macrophages at the wound site. Read More

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http://dx.doi.org/10.1002/stem.3022DOI Listing

Multiple interleaved mode saturation (MIMOSA) for B inhomogeneity mitigation in chemical exchange saturation transfer.

Magn Reson Med 2019 Apr 19. Epub 2019 Apr 19.

Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Germany.

Purpose: To mitigate inhomogeneity in quantitative CEST MRI at ultra-high magnetic field strengths (B ≥ 7 Tesla) using a parallel transmit system.

Methods: Multiple interleaved mode saturation employs interleaving of 2 complementary phase sets during the saturation pulse train. Phase differences of 45° (first mode) and 90° (second mode) between 2 adjacent transmitter coil channels are used. Read More

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http://dx.doi.org/10.1002/mrm.27762DOI Listing

HbA1c showed a positive association with carcinoembryonic antigen (CEA) level in only diabetes, not prediabetic or normal individuals.

J Clin Lab Anal 2019 Apr 19:e22900. Epub 2019 Apr 19.

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.

Background: This study was conducted to investigate the association of carcinoembryonic antigen (CEA) and glycated hemoglobin (HbA1c) in normal, prediabetic, and diabetic subjects.

Methods: A total of 2,911 participants who underwent general health checkups were enrolled and categorized into the normal, prediabetes, and diabetes groups. Demographic, anthropological, and clinical variables were investigated, and correlations with CEA were analyzed. Read More

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http://dx.doi.org/10.1002/jcla.22900DOI Listing

Taking Care of the Dyad: Frequency of Caregiver Assessment Among Veterans with Dementia.

J Am Geriatr Soc 2019 Apr 19. Epub 2019 Apr 19.

Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas.

Objectives: This study assessed frequency of caregiver identification and needs of a sample of persons with dementia (PWDs) and their caregivers to determine whether needs were addressed and whether documentation increased with growing levels of self-reported relationship problems and burden.

Design: Cross-sectional design using data from electronic medical record (EMR) review and baseline research assessments (Burden Interview and Mutuality Scale). Items from a caregiver assessment tool were used to identify documentation of important factors in clinical guidelines. Read More

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http://dx.doi.org/10.1111/jgs.15882DOI Listing
April 2019
2 Reads

The missing reality of real life in real-world evidence.

Authors:
Sally Okun

Clin Pharmacol Ther 2019 Apr 19. Epub 2019 Apr 19.

PatientsLikeMe, Cambridge, MA.

Reality is defined as a real event, a real thing or state of affairs. Reality exists in the places where we live our daily lives, in the relationships we have with others and in our experiences, circumstances, and situations that occur across the lifespan. As the everydayness of our lives become increasingly digitized data generated from the reality that exists outside of our healthcare encounters holds much promise to fill recognized gaps in real-world evidence. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cpt.1465
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http://dx.doi.org/10.1002/cpt.1465DOI Listing
April 2019
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Factors associated with antibiotic prescribing for adults with acute conditions: an umbrella review across primary care and a systematic review focusing on primary dental care.

J Antimicrob Chemother 2019 Apr 19. Epub 2019 Apr 19.

University of Leeds/Leeds Teaching Hospitals NHS Trust, Leeds, UK.

Introduction: One way to slow the spread of resistant bacteria is by improved stewardship of antibiotics: using them more carefully and reducing the number of prescriptions. With an estimated 7%-10% of antibiotic prescriptions globally originating from dental practices and up to 80% prescribed unnecessarily, dentistry has an important role to play. To support the design of new stewardship interventions through knowledge transfer between contexts, this study aimed to identify factors associated with the decision to prescribe antibiotics to adults presenting with acute conditions across primary care (including dentistry). Read More

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http://dx.doi.org/10.1093/jac/dkz152DOI Listing

US Emergency Department Visits and Hospital Discharges Among Uninsured Patients Before and After Implementation of the Affordable Care Act.

JAMA Netw Open 2019 Apr 5;2(4):e192662. Epub 2019 Apr 5.

US Acute Care Solutions, Canton, Ohio.

Importance: The US Patient Protection and Affordable Care Act of 2010 (ACA) was enacted in 2010 with several provisions that targeted reducing numbers of uninsured Americans.

Objective: To assess the numbers and proportion of emergency department (ED) visits (2006-2016) and hospital discharges (2006-2016) by uninsured patients, focusing on the 2014 ACA insurance reforms (Medicaid expansion, individual mandate, and private insurance exchanges).

Design, Setting, And Participants: Cross-sectional study of visitors to US EDs and patients discharged from US hospitals using National Hospital Ambulatory Care Survey data and Healthcare Cost and Utilization Project data, respectively, from 2006 to 2016. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.2662DOI Listing

Factors Associated With Use of Sipuleucel-T to Treat Patients With Advanced Prostate Cancer.

JAMA Netw Open 2019 Apr 5;2(4):e192589. Epub 2019 Apr 5.

Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor.

Importance: Sipuleucel-T is an immunotherapy that has been approved for use in patients with asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). However, sipuleucel-T may not be available to some patients because of logistics, cost, and practice structure.

Objective: To identify factors associated with the adoption of sipuleucel-T across the United States. Read More

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http://jamanetworkopen.jamanetwork.com/article.aspx?doi=10.1
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http://dx.doi.org/10.1001/jamanetworkopen.2019.2589DOI Listing
April 2019
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Comparison of a Potential Hospital Quality Metric With Existing Metrics for Surgical Quality-Associated Readmission.

JAMA Netw Open 2019 Apr 5;2(4):e191313. Epub 2019 Apr 5.

Veterans Affairs, Palo Alto, Veterans Affairs Medical Center, Palo Alto, California.

Importance: The existing readmission quality metric does not meaningfully distinguish readmissions associated with surgical quality from those that are not associated with surgical quality and thus may not reflect the quality of surgical care.

Objective: To compare a quality metric that classifies readmissions associated with surgical quality with the existing metric of any unplanned readmission in a surgical population.

Design, Setting, And Participants: Cohort study using US nationwide administrative data collected on 4 high-volume surgical procedures performed at 103 Veterans Affairs hospitals from October 1, 2007, through September 30, 2014. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.1313DOI Listing

Clinical Accountability and Measuring Surgical Readmissions.

JAMA Netw Open 2019 Apr 5;2(4):e191301. Epub 2019 Apr 5.

Center for Healthcare Outcomes and Policy, University of Michigan, Ann Arbor.

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http://dx.doi.org/10.1001/jamanetworkopen.2019.1301DOI Listing

A Scoping Review of Nonpharmacological Interventions to Reduce Disability in Older Adults.

Gerontologist 2019 Apr 19. Epub 2019 Apr 19.

Department of Occupational Therapy, School of Health and Rehabilitation Science, Pennsylvania.

Background And Objectives: Minimizing disability is critical to reduce the costly health care associated with disability and maintain quality of life into old age. We examined the effect sizes of nonpharmacological intervention studies in reducing disability and explored the active ingredients of interventions.

Research Design And Methods: A scoping review was conducted via PubMed, PsycINFO, and CINAHL databases. Read More

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http://dx.doi.org/10.1093/geront/gnz026DOI Listing

Thriving in today's health care environment: strategies for social work leadership in population health.

Soc Work Health Care 2019 Apr 19:1-20. Epub 2019 Apr 19.

a Mount Sinai Health Partners , Mount Sinai Health System , New York , NY , USA.

The current healthcare environment challenges social workers to balance multiple constituencies - organizational, payer-related, and professional - and convey the value-added nature of clinical work with patients and families. As healthcare systems move towards population health, leadership opportunities abound. This article provides an historical overview of healthcare transformation and its impact on social work practice, and describes strategies implemented to bolster the clinical focus and organizational responsiveness of Mount Sinai Health System care management staff. Read More

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http://dx.doi.org/10.1080/00981389.2019.1602099DOI Listing
April 2019
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The qualculative dimension of healthcare data interoperability.

Authors:
Kathleen H Pine

Health Informatics J 2019 Apr 19:1460458219833095. Epub 2019 Apr 19.

Arizona State University, USA.

Research on interoperability and information exchange between information technology systems touts the use of secondary data for a variety of purposes, including research, management, quality improvement, and accountability. However, many studies have pointed out that this is difficult to achieve in practice. Hence, this article aims to examine the causes for this by reporting an ethnographic study of the data work performed by medical records coders and birth certificate clerks working in a hospital system to uncover the practices of creating administrative data (e. Read More

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http://journals.sagepub.com/doi/10.1177/1460458219833095
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http://dx.doi.org/10.1177/1460458219833095DOI Listing
April 2019
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Home deaths of children under 5 years in rural South Africa: a population-based longitudinal study.

Trop Med Int Health 2019 Apr 19. Epub 2019 Apr 19.

Nuffield Department of Primary Care Health Sciences, University of Oxford, UK.

Objectives: To determine the proportion of under-5 deaths that occurred at home in rural South Africa, whether care was sought prior to death, and determinants of home deaths amongst those who sought care.

Methods: Verbal autopsy data were used for all under-5 deaths, 2000-2015, in two health and demographic surveillance system sites. Trends in place of death and care-seeking were assessed. Read More

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http://dx.doi.org/10.1111/tmi.13239DOI Listing

Benefits and hazards of electromagnetic waves, telecommunication, physical and biomedical: a review.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3121-3128

Department of Information Engineering, Electronics and Telecommunications, Sapienza University of Rome, Rome, Italy.

Objective: The aim of this paper is to review the current literature on electromagnetic radiation (EMR): physical, biophysical, and telecommunication. The widespread application of EMR in modern technologies requires telecommunication and healthcare professionals to possess some knowledge of its physical and biological properties. In this review article, we will discuss biophysical principles of EMR, its interactions with living organisms and its application in clinical practices. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17596DOI Listing
April 2019
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Costs of irritable bowel syndrome in European countries with universal healthcare coverage: a meta-analysis.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2986-3000

Regional Healthcare Agency of Abruzzo, Pescara, Italy.

Objective: To provide an overall estimate of the direct, indirect and total costs of irritable bowel syndrome (IBS) for the adult population of the European countries with universal healthcare coverage.

Materials And Methods: We searched MedLine and Scopus databases (up to September 2018) to identify the European studies that evaluated the economic impact of IBS. Mean annual direct, indirect and total per-capita IBS costs were estimated using random-effect single-group meta-analyses of continuous data. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17580DOI Listing

Novel Sequence Type in Bacillus cereus Strains Associated with Nosocomial Infections and Bacteremia, Japan.

Emerg Infect Dis 2019 May;25(5):883-890

Bacillus cereus is associated with foodborne illnesses characterized by vomiting and diarrhea. Although some B. cereus strains that cause severe extraintestinal infections and nosocomial infections are recognized as serious public health threats in healthcare settings, the genetic backgrounds of B. Read More

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http://dx.doi.org/10.3201/eid2505.171890DOI Listing

Outbreak of Nontuberculous Mycobacteria Joint Prosthesis Infections, Oregon, USA, 2010-2016.

Emerg Infect Dis 2019 May;25(5):849-855

We investigated a cluster of Mycobacterium fortuitum and M. goodii prosthetic joint surgical site infections occurring during 2010-2014. Cases were defined as culture-positive nontuberculous mycobacteria surgical site infections that had occurred within 1 year of joint replacement surgery performed on or after October 1, 2010. Read More

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http://dx.doi.org/10.3201/eid2505.181687DOI Listing
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