4,372,709 results match your criteria Health & Place [Journal]


The double burden of food insecurity and obesity among Latino youth: Understanding the role of generational status.

Pediatr Obes 2019 Apr 25:e12525. Epub 2019 Apr 25.

Department of Public Health Education, University of North Carolina, Greenboro, NC, USA.

Background: Obesity is linked to food insecurity and generational status; however, little is known about how both impact obesity risk among Latino youth.

Objective: To investigate the joint effect of generational status and food insecurity on obesity prevalence among Latino youth.

Methods: We pooled data from the 2011 to 2017 waves of the National Health Interview Survey to derive a sample Latino youth aged 12 to 17 (N = 7532). Read More

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http://dx.doi.org/10.1111/ijpo.12525DOI Listing

Low Plasma Sodium Concentration Predicts Perforated Acute Appendicitis in Children: A Prospective Diagnostic Accuracy Study.

Eur J Pediatr Surg 2019 Apr 25. Epub 2019 Apr 25.

Department of Pediatric Perioperative Medicine and Intensive Care, Astrid Lindgren Children's Hospital, Karolinska University Hospital Solna, Stockholm, Sweden.

Background:  Early differentiation between perforated and nonperforated acute appendicitis (AA) in children is of major benefit for the selection of proper treatment. Based on pilot study data, we hypothesized that plasma sodium concentration at hospital admission is a diagnostic marker for perforation in children with AA.

Materials And Methods:  This was a prospective diagnostic accuracy study, including previously healthy children, 1 to 14 years of age, with AA. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1687870
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http://dx.doi.org/10.1055/s-0039-1687870DOI Listing
April 2019
1 Read

Artificial Intelligence in Clinical Decision Support: Challenges for Evaluating AI and Practical Implications.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Macquarie University, Australian Institute of Health Innovation, Sydney, Australia.

Objectives: This paper draws attention to: i) key considerations for evaluating artificial intelligence (AI) enabled clinical decision support; and ii) challenges and practical implications of AI design, development, selection, use, and ongoing surveillance.

Method: A narrative review of existing research and evaluation approaches along with expert perspectives drawn from the International Medical Informatics Association (IMIA) Working Group on Technology Assessment and Quality Development in Health Informatics and the European Federation for Medical Informatics (EFMI) Working Group for Assessment of Health Information Systems.

Results: There is a rich history and tradition of evaluating AI in healthcare. Read More

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http://dx.doi.org/10.1055/s-0039-1677903DOI Listing

Artificial Intelligence in Primary Health Care: Perceptions, Issues, and Challenges.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Department of Clinical & Experimental Medicine, University of Surrey, Guildford, Surrey, UK.

Background: Artificial intelligence (AI) is heralded as an approach that might augment or substitute for the limited processing power of the human brain of primary health care (PHC) professionals. However, there are concerns that AI-mediated decisions may be hard to validate and challenge, or may result in rogue decisions.

Objective: To form consensus about perceptions, issues, and challenges of AI in primary care. Read More

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http://dx.doi.org/10.1055/s-0039-1677901DOI Listing

Role of Artificial Intelligence within the Telehealth Domain.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

IBM Research, Brazil.

Objectives: This paper provides a discussion about the potential scope of applicability of Artificial Intelligence methods within the telehealth domain. These methods are focussed on clinical needs and provide some insight to current directions, based on reports of recent advances.

Methods: Examples of telehealth innovations involving Artificial Intelligence to support or supplement remote health care delivery were identified from recent literature by the authors, on the basis of expert knowledge. Read More

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http://dx.doi.org/10.1055/s-0039-1677897DOI Listing

Artificial Intelligence for Participatory Health: Applications, Impact, and Future Implications.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Swinburne University of Technology, and University of Melbourne, Australia.

Objective: Artificial intelligence (AI) provides people and professionals working in the field of participatory health informatics an opportunity to derive robust insights from a variety of online sources. The objective of this paper is to identify current state of the art and application areas of AI in the context of participatory health.

Methods: A search was conducted across seven databases (PubMed, Embase, CINAHL, PsychInfo, ACM Digital Library, IEEExplore, and SCOPUS), covering articles published since 2013. Read More

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http://dx.doi.org/10.1055/s-0039-1677902DOI Listing

The Interplay of Knowledge Representation with Various Fields of Artificial Intelligence in Medicine.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Associate Professor, Department of Medical Informatics, Academic Medical Center - University of Amsterdam, Amsterdam Public Health research institute, Amsterdam, The Netherlands.

Introduction: Artificial intelligence (AI) is widespread in many areas, including medicine. However, it is unclear what exactly AI encompasses. This paper aims to provide an improved understanding of medical AI and its constituent fields, and their interplay with knowledge representation (KR). Read More

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http://dx.doi.org/10.1055/s-0039-1677899DOI Listing

Serious Games in Health Professions Education: Review of Trends and Learning Efficacy.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Games for Health Innovations Centre, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.

Objectives: To provide an overview of research trends and a review regarding the learning efficacy of serious games for health professions education taking into account short-term learning outcomes.

Methods: For the review of research trends, we performed the search on Web of Science from 1996 until the present. For the scoping review on learning efficacy, ERIC, Education Source, PsychINFO, Global Health, CINAHL, Web Of Science, and Medline were searched. Read More

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http://dx.doi.org/10.1055/s-0039-1677904DOI Listing

The Price of Artificial Intelligence.

Authors:
Enrico Coiera

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Australian Institute of Health Innovation, Macquarie University, Sydney, NSW, Australia.

Introduction: Whilst general artificial intelligence (AI) is yet to appear, today's narrow AI is already good enough to transform much of healthcare over the next two decades.

Objective: There is much discussion of the potential benefits of AI in healthcare and this paper reviews the cost that may need to be paid for these benefits, including changes in the way healthcare is practiced, patients are engaged, medical records are created, and work is reimbursed.

Results: Whilst AI will be applied to classic pattern recognition tasks like diagnosis or treatment recommendation, it is likely to be as disruptive to clinical work as it is to care delivery. Read More

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http://dx.doi.org/10.1055/s-0039-1677892DOI Listing

Artificial Intelligence in Medicine: Weighing the Accomplishments, Hype, and Promise.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Department of Biomedical Informatics, Columbia University.

Introduction: Artificial Intelligence in Medicine (AIM) research is now 50 years old, having made great progress that has tracked the corresponding evolution of computer science, hardware technology, communications, and biomedicine. Characterized as being in its "adolescence" at an international meeting in 1991, and as "coming of age" at another meeting in 2007, the AIM field is now more visible and influential than ever before, paralleling the enthusiasm and accomplishments of artificial intelligence (AI) more generally.

Objectives: This article summarizes some of that AIM history, providing an update on the status of the field as it enters its second half-century. Read More

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http://dx.doi.org/10.1055/s-0039-1677891DOI Listing

Beginnings of Artificial Intelligence in Medicine (AIM): Computational Artifice Assisting Scientific Inquiry and Clinical Art - with Reflections on Present AIM Challenges.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Department of Computer Science, Rutgers University, USA.

Background: The rise of biomedical expert heuristic knowledge-based approaches for computational modeling and problem solving, for scientific inquiry and medical decision-making, and for consultation in the 1970's led to a major change in the paradigm that affected all of artificial intelligence (AI) research. Since then, AI has evolved, surviving several "winters", as it has oscillated between relying on expensive and hard-to-validate knowledge-based approaches, and the alternative of using machine learning methods for inferring classification rules from labelled datasets. In the past couple of decades, we are seeing a gradual but progressive intertwining of the two. Read More

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http://dx.doi.org/10.1055/s-0039-1677895DOI Listing

On the 80th Birthday of Jan van Bemmel.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Dept. of Medical informatics, Erasmus University, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1055/s-0039-1677893DOI Listing

Assessment of the Relationship Between Serum High Molecular Weight Adiponectin Hormone Levels and Insulin Resistance in Patients with Polycystic Ovary Syndrome.

Horm Metab Res 2019 Apr 25;51(4):261-266. Epub 2019 Apr 25.

VKV American Hospital, Women's Healthcare Centre, Istanbul, Turkey.

The purpose of this study was to assess the rate of insulin resistance (IR) and the relationship between IR and high-molecular weight adiponectin (HMWA) in patients with polycystic ovary syndrome (PCOS). A cross sectional study involving 43 women with PCOS and 39 normal women was carried out over a period of nine months. Fasting glucose and insulin levels, lipid parameters and androgen levels were measured in all serum samples. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0867-0886
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http://dx.doi.org/10.1055/a-0867-0886DOI Listing
April 2019
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Characterization of a Novel POU1F1 Mutation Identified on Screening 160 Growth Hormone Deficiency Patients.

Horm Metab Res 2019 Apr 25;51(4):248-255. Epub 2019 Apr 25.

Laboratory of Cyto-Molecular Genetics, Department of Anatomy, All India Institute of Medical Sciences (AIIMS), New Delhi, India.

The objective of the study is the functional characterization of a novel c.605delC mutation in combined pituitary hormone deficiency (CPHD) and to report the clinical and genetic details of 160 growth hormone deficiency patients. Screening of , , , , and genes by Sanger sequencing was carried out in 160 trios and 100 controls followed by characterization of the c. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0867-1026
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http://dx.doi.org/10.1055/a-0867-1026DOI Listing
April 2019
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Serum Prostate-Specific Antigen Level in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis.

Horm Metab Res 2019 Apr 25;51(4):230-242. Epub 2019 Apr 25.

Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

We undertook a comprehensive search of all published original articles evaluating the diagnostic value of prostate-specific antigen (PSA) for the detection of polycystic ovary syndrome (PCOS). Finally, 25 studies with a total of 1865 participants (1104 cases and 761 controls) met the inclusion criteria. Mean serum PSA levels were significantly higher in PCOS women compared to healthy women [Standardized mean difference (SMD)=1. Read More

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http://dx.doi.org/10.1055/a-0863-5779DOI Listing

Social Network Structure in Young Stroke Survivors with Aphasia: A Case Series Report.

Semin Speech Lang 2019 Apr 25. Epub 2019 Apr 25.

Communication Equity and Outcomes Laboratory, College of Allied Health Sciences East Carolina University, Greenville, North Carolina.

The aim of this study was to profile the social networks of young adult stroke survivors with aphasia. A case series approach using four persons with aphasia (PWA) younger than 50 years was utilized. Semistructured interviews were completed with the PWA and their primary caregiver/family to explore the most salient relationships in the PWA's social network. Read More

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http://dx.doi.org/10.1055/s-0039-1688695DOI Listing

Transition from video-assisted thoracoscopic to robotic esophagectomy: a single surgeon's experience.

Dis Esophagus 2019 Apr 25. Epub 2019 Apr 25.

Department of Cardiothoracic Surgery, New York University Langone Health, New York, USA.

Lymph node dissection (LND) along the left recurrent laryngeal nerve (RLN) is a technically challenging part of esophageal cancer surgery, especially after chemoradiotherapy (CRT). Robotic surgery holds promise to increase its safety and feasibility. The aim of this study was to describe a single thoracoscopic surgeon's experience related to the transition from video-assisted esophagectomy (VATE) to robotic esophagectomy (RE)-with a special focus on the safety of left RLN LND. Read More

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http://dx.doi.org/10.1093/dote/doz033DOI Listing

IL-22: There Is a Gap in Our Knowledge.

Immunohorizons 2018 Jul 5;2(6):198-207. Epub 2018 Jul 5.

Department of Microbiology and Immunology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104

IL-22 is a critical cytokine in modulating tissue responses during inflammation. IL-22 is upregulated in many chronic inflammatory diseases, making IL-22 biology a potentially rewarding therapeutic target. However, this is complicated by the dual-natured role of IL-22 in inflammation, as the cytokine can be protective or inflammatory depending on the disease model. Read More

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http://dx.doi.org/10.4049/immunohorizons.1800006DOI Listing

Breadth and Dynamics of HLA-A2- and HLA-B7-Restricted CD8 T Cell Responses against Nonstructural Viral Proteins in Acute Human Tick-Borne Encephalitis Virus Infection.

Immunohorizons 2018 Jul 2;2(6):172-184. Epub 2018 Jul 2.

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, 141 86 Stockholm, Sweden;

Tick-borne encephalitis virus (TBEV) is a leading cause of viral meningoencephalitis in many parts of Europe and eastwards in Asia, with high morbidity and often long-term neurologic sequelae. With no treatment available, studies of the immune response to TBEV are essential for the understanding of the immunopathogenesis of tick-borne encephalitis and for the development of therapeutics. We have previously demonstrated that CD8 T cell responses in peripheral blood in patients with acute TBEV peak at around 7 d after hospitalization in the neuroinvasive phase of the disease. Read More

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http://dx.doi.org/10.4049/immunohorizons.1800029DOI Listing

Open, Laparoscopic, and Robotic Inguinal Hernia Repair: Outcomes and Predictors of Complications.

J Surg Res 2019 Apr 22;241:119-127. Epub 2019 Apr 22.

Department of Surgery, University of Texas Southwestern Medical Center, Harold C. Simmons Comprehensive Cancer Center, Dallas, Texas.

Background: The robotic approach to an inguinal hernia has not been compared head to head with the open and laparoscopic techniques in randomized controlled trials. Furthermore, long-term outcomes for robotic inguinal hernia repair (RHR) are lacking. In this study, we compared laparoscopic inguinal hernia repair (LHR) and RHR with open inguinal hernia repair (OHR) in veteran patients performed by surgeons most familiar with each approach. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.046DOI Listing

Gender- and age-dependencies of oxidative stress, as detected based on the steady state concentrations of different biomarkers in the MARK-AGE study.

Redox Biol 2019 Apr 15;24:101204. Epub 2019 Apr 15.

Department of Physiology and Pharmacology, Sackler Medical School, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Recently, Weber et al. published a thorough investigation of the age-dependency of oxidative stress (OS) determined by the steady state concentrations of different compounds - oxidation products and antioxidants - that are in common use as biomarkers of OS in 2207 healthy individuals of the cross-sectional MARK-AGE Project. The correlations among biomarkers were significant but weak. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101204DOI Listing

Cholesterol crystals promote endothelial cell and monocyte interactions via HO-mediated PP2A inhibition, NFκB activation and ICAM1 and VCAM1 expression.

Redox Biol 2019 Apr 3;24:101180. Epub 2019 Apr 3.

Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address:

In the present study, we show that cholesterol crystals induce NFκB activation, and ICAM1 and VCAM1 expression via xanthine oxidase-mediated HO production and PP2A inhibition in influencing endothelial cell and monocyte interactions and all these adverse effects of cholesterol crystals could be attenuated by proresolving lipid mediator RvD1. In addition, feeding mice with cholesterol rich diet (CRD) increased xanthine oxidase expression, its activity and HO production leading to PP2A inhibition, NFκB activation, and ICAM1 and VCAM1 expression and RvD1 attenuated all these effects of CRD substantially. Furthermore, peripheral blood mononuclear cells (PBMCs) from wild type mice when injected into mice that were fed with CRD or RvD1 + CRD showed increased leukocyte trafficking to arteries of CRD-fed mice as compared to RvD1 + CRD mice. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132317193031
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http://dx.doi.org/10.1016/j.redox.2019.101180DOI Listing
April 2019
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High seizure load during sensitive periods of development leads to broad shifts in ultrasonic vocalization behavior in neonatal male and female C57BL/6J mice.

Epilepsy Behav 2019 Apr 22;95:26-33. Epub 2019 Apr 22.

Department of Psychology and Neuroscience, Baylor University, Waco, TX 76798, USA; Institute of Biomedical Studies, Baylor University, Waco, TX 76798, USA; Department of Biology, Baylor University, Waco, TX 76798, USA. Electronic address:

There is increasing evidence that seizures during early development can impact ultrasonic vocalizations (USVs) emitted from neonatal mice. However, most of the effects of early-life seizures have been reported using chemoconvulsants that produce continuous seizures (status epilepticus). In the present study, we evaluated the impact of different seizure frequency loads during early-life vocalization development in C57BL/6J male and female mice. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.03.037DOI Listing

The effects of textured materials on static balance in healthy young and older adults: A systematic review with meta-analysis.

Gait Posture 2019 Apr 17;71:79-86. Epub 2019 Apr 17.

School of Health and Social Care, Teesside University, Middlesbrough, UK. Electronic address:

Background: Standing on textured materials can improve static balance, potentially by modulating somatosensory inputs from the soles of the feet.

Research Question: To synthesise and quantify the immediate effects of textured materials on static balance in healthy young and older adults.

Methods: Primary outcomes were the centre of pressure (COP) displacement and velocity, during eyes open and eyes closed conditions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09666362183189
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http://dx.doi.org/10.1016/j.gaitpost.2019.04.017DOI Listing
April 2019
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Inorganic and organic fertilizers application enhanced antibiotic resistome in greenhouse soils growing vegetables.

Ecotoxicol Environ Saf 2019 Apr 22;179:24-30. Epub 2019 Apr 22.

Beijing Agro-Biotechnology Research Center, Beijing Key Laboratory of Agricultural Genetic Resources and Biotechnology, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China. Electronic address:

Antibiotic resistance genes (ARGs) and antibiotic-resistant bacteria (ARB) in fertilizers pose risks to human health and their variation in soil after fertilization has been reported. However, some important questions, such as the origin of ARG and ARB observed in soil following fertilization, which are present in soil regardless of fertilizer type (i.e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513193046
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http://dx.doi.org/10.1016/j.ecoenv.2019.04.039DOI Listing
April 2019
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Characteristics and risk assessments of heavy metals in fine and coarse particles in an industrial area of central China.

Ecotoxicol Environ Saf 2019 Apr 22;179:1-8. Epub 2019 Apr 22.

School of Municipal and Environmental Engineering, Co-Innovation Center for Green Building of Shandong Province, Shandong Jianzhu University, Jinan, 250101, China; Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Fudan University, Shanghai, 200433, China. Electronic address:

In order to investigate the pollution level and chemical form transformation characteristics of heavy metals, atmospheric fine particles and coarse particles were collected in an urban industrial area of Zhuzhou City in central China during winter and summer. The results indicated that PM and PM all showed similar time variation, with the highest concentration in winter (112.1 μg/m, 210. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.024DOI Listing

Emotional Semantic Congruency based on stimulus driven comparative judgements.

Cognition 2019 Apr 22;190:20-41. Epub 2019 Apr 22.

Department of Life Sciences, Psychology Unit "Gaetano Kanizsa", University of Trieste, Via E. Weiss 2, 34128 Trieste, Italy. Electronic address:

A common cognitive process in everyday life consists in the comparative judgements of emotions given a pair of facial expressions and the choice of the most positive/negative among them. Results from three experiments on complete-facial expressions (happy/angry) and mixed-facial expressions (neutral/happy-or-angry) pairs viewed with (Experiment 1 and 3) or without (Experiment 2) foveation and performed in conditions in which valence was either task relevant (Experiment 1 and 2) or task irrelevant (Experiment 3), show that comparative judgements of emotions are stimulus driven. Judgements' speed increased as the target absolute emotion intensity grew larger together with the average emotion of the pair, irrespective of the compatibility between the valence and the side of motor response: a semantic congruency effect in the domain of emotion. Read More

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http://dx.doi.org/10.1016/j.cognition.2019.04.014DOI Listing

First evidence of protein modulation by polystyrene microplastics in a freshwater biological model.

Environ Pollut 2019 Apr 17;250:407-415. Epub 2019 Apr 17.

Department of Biosciences, University of Milan, Via Celoria 26, 20133, Milan, Italy. Electronic address:

Microplastics (MPs) are now one of the major environmental problems due to the large amount released in aquatic and terrestrial ecosystems, as well as their diffuse sources and potential impacts on organisms and human health. Still the molecular and cellular targets of microplastics' toxicity have not yet been identified and their mechanism of actions in aquatic organisms are largely unknown. In order to partially fill this gap, we used a mass spectrometry based functional proteomics to evaluate the modulation of protein profiling in zebra mussel (Dreissena polymorpha), one of the most useful freshwater biological model. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.04.088DOI Listing

Use of toxicant sensitivity distributions (TSD) for development of exposure guidelines for risk to human health from benzene.

Environ Pollut 2019 Apr 10;250:386-396. Epub 2019 Apr 10.

School of Environment and Sciences, Griffith University, Nathan Campus, Brisbane, 4111, QLD, Australia.

This technique for setting guideline values differs from that currently used by regulatory agencies throughout the world. Data for benzene were evaluated from epidemiological studies on human populations (29 studies). Exposure durations were evaluated in terms of Long Term Exposure (LTE) and Lifetime Exposure. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.04.001DOI Listing

Dexamethasone ameliorates the damage of hippocampal filamentous actin cytoskeleton but is not sufficient to cease epileptogenesis in pilocarpine induced epileptic mice.

Epilepsy Res 2019 Apr 18;154:26-33. Epub 2019 Apr 18.

Department of Pediatric Neurology, The First Hospital of Jilin University, Changchun, Jilin Province 130021, PR China. Electronic address:

Rogressive deconstruction of filament actin (F-actin) in hippocampal neurons in the epileptic brain have been associated with epileptogenesis. Previous clinical studies suggest that glucocorticoids treatment plays beneficial roles in refractory epilepsy. Glucocorticoids treatment affects dendritic spine morphology by regulating local glucocorticoid receptors and F-actin cytoskeleton dynamics. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.04.009DOI Listing

Long-term safety and efficacy of cannabidiol in children and adults with treatmentresistant Lennox-Gastaut syndrome or Dravet syndrome: Expanded access program results.

Epilepsy Res 2019 Mar 25;154:13-20. Epub 2019 Mar 25.

Oishei Children's Hospital, Buffalo, NY, USA.

Background: Since 2014, patients with severe treatment-resistant epilepsies (TREs) have been receiving add-on cannabidiol (CBD) in an ongoing, expanded access program (EAP), which closely reflects clinical practice. We conducted an interim analysis of long-term efficacy and tolerability in patients with Lennox-Gastaut syndrome (LGS) or Dravet syndrome (DS) who received CBD treatment through December 2016.

Methods: Children and adults with LGS/DS taking stable doses of antiepileptic drugs (AEDs) at baseline were included from 25 EAP sites across the United States. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.015DOI Listing

Effectiveness of school-based health center delivery of a cognitive skills building intervention in young, rural adolescents: Potential applications for addiction and mood.

J Pediatr Nurs 2019 Apr 22;47:23-29. Epub 2019 Apr 22.

University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, United States of America. Electronic address:

Purpose: Uniquely positioned, school nurses address two of the most critical adolescent health issues - addiction and mood. Cognitive behavioral therapy, the mainstay in management of adolescent mood disorders, demonstrates promise in the treatment and prevention of addictive behaviors. Quality decision-making may protect adolescents from substance abuse. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08825963193014
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http://dx.doi.org/10.1016/j.pedn.2019.04.013DOI Listing
April 2019
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Physician altruism and moral hazard: (no) Evidence from Finnish national prescriptions data.

J Health Econ 2019 Mar 19;65:153-169. Epub 2019 Mar 19.

Paris School of Economics - École d'Économie de Paris, Hospinnomics, Hôtel-Dieu, 1, Parvis de Notre-Dame, Bâtiment B1, 5° étage, 75004, Paris, France; Imperial College Business School, Department of Management & Centre for Health Economics & Policy Innovation (CHEPI), South Kensington Campus, SW7 2AZ, London, UK. Electronic address:

We test the physicians' altruism and moral hazard hypotheses using a national panel register containing all 2003-2010 statins prescriptions in Finland. We estimate the likelihood that physicians prescribe generic versus branded versions of statins as a function of the shares of the difference between what patients have to pay out of their pocket and what is covered by the insurance, controlling for patient, physician, and drug characteristics. We find that the estimated coefficients and the average marginal effects associated with moral hazard and altruism are nearly zero, and are orders of magnitude smaller than the ones associated with other explanatory factors such as the prescriptions' year and the physician specialization. Read More

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http://dx.doi.org/10.1016/j.jhealeco.2019.03.006DOI Listing

Hippocampal subfield volumes and childhood trauma in bipolar disorders.

J Affect Disord 2019 Apr 10;253:35-43. Epub 2019 Apr 10.

IRCCS Santa Lucia Foundation, Laboratory of Neuropsychiatry, Rome, Italy; Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. Electronic address:

Background: Alterations in hippocampal structure and function are present in bipolar disorder (BD). Childhood trauma is associated with risk for BD, and the several subfields of the hippocampus are differentially sensitive to the effects of stressors of the sort associated with risk for BD. The current study therefore sought to test the hypothesis that childhood trauma may be differentially associated with abnormal hippocampal subfield volumes in BD. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.071DOI Listing

Solidification of sand by Pb(II)-tolerant bacteria for capping mine waste to control metallic dust: Case of the abandoned Kabwe Mine, Zambia.

Chemosphere 2019 Apr 16;228:17-25. Epub 2019 Apr 16.

Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-Ku, Sapporo, 060-0818, Japan.

Environmental impacts resulting from historic lead and zinc mining in Kabwe, Zambia affect human health due to the dust generated from the mine waste that contains lead, a known hazardous pollutant. We employed microbially induced calcium carbonate precipitation (MICP), an alternative capping method, to prevent dust generation and reduce the mobility of contaminants. Pb-resistant Oceanobacillus profundus KBZ 1-3 and O. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.107DOI Listing

Salting out assisted liquid-liquid extraction for liquid chromatography tandem-mass spectrometry determination of amphetamine-like stimulants in meconium.

J Pharm Biomed Anal 2019 Apr 17;172:42-49. Epub 2019 Apr 17.

Institute of Forensic Medicine and Toxicology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 2, 121 08 Prague 2, Czech Republic; Department of Analytical Chemistry, Faculty of Science, Charles University, Albertov 6, 128 43 Prague 2, Czech Republic. Electronic address:

In the last decade there has been a dramatic increase in the availability and abuse of synthetic cathinones - new amphetamine-like stimulants. Even though their abuse during pregnancy could have serious adverse effects on the fetus, cathinones are not readily included in neonatal toxicological screenings. Meconium (first neonatal stool) is the specimen of choice to reveal long term drug exposure, however as it is a highly complex matrix, the sample preparation is a critical step before the instrumental analysis. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.04.036DOI Listing

Preventing and mitigating health risks of climate change.

Authors:
S Tong K Ebi

Environ Res 2019 Apr 16;174:9-13. Epub 2019 Apr 16.

Center for Health and the Global Environment, USA.

Global environmental changes, driven by the consequences of human activities and population growth, are altering our planet in ways that pose current threats to human health, with the magnitude of these threats projected to increase over coming decades if additional, proactive actions are not taken. Global changes, unprecedented in their geospatial and temporal scales, include climate change, marine pollution, ozone layer depletion, soil degradation, and urbanization. Climate change is the best studied. Read More

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http://dx.doi.org/10.1016/j.envres.2019.04.012DOI Listing

The role of nuclear receptors in the differentiation of oligodendrocyte precursor cells derived from fetal and adult neural stem cells.

Stem Cell Res 2019 Apr 17;37:101443. Epub 2019 Apr 17.

Health Science and Technologies Interdepartmental Center for Industrial Research (HST-ICIR), University of Bologna, Italy; Department of Pharmacy and Biotechnology, University of Bologna, Italy; IRET Foundation, Ozzano Emilia, Italy.

Oligodendrocyte precursor cells (OPCs) differentiation from multipotent neural stem cells (NSCs) into mature oligodendrocytes is driven by thyroid hormone and mediated by thyroid hormone receptors (TRs). We show that several nuclear receptors display strong changes in expression levels between fetal and adult NSCs, with an overexpression of TRβ and a lower expression of RXRγ in adult. Such changes may determine the reduced capacity of adult OPCs to differentiate as supported by reduced yield of maturation and compromised mRNA expression of key genes. Read More

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http://dx.doi.org/10.1016/j.scr.2019.101443DOI Listing

There's a frog in my salad! A review of online media coverage for wild vertebrates found in prepackaged produce in the United States.

Sci Total Environ 2019 Mar 19;675:1-12. Epub 2019 Mar 19.

Department of Agricultural and Biological Engineering, University of Illinois Urbana-Champaign, 1304 West Pennsylvania Avenue, Urbana, IL 61801, USA. Electronic address:

Prepackaged leafy green vegetables represent one of the fastest growing segments of the fresh-produce industry in the United States. Several steps in the production process have been mechanized to meet the downstream demand for prebagged lettuces. The growth in this market, however, has come with drawbacks, and chief among them are consumers finding wild animals in prepackaged crops. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.254DOI Listing
March 2019
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Human Amniotic Epithelial Cell-Derived Exosomes Restore Ovarian Function by Transferring MicroRNAs against Apoptosis.

Mol Ther Nucleic Acids 2019 Apr 6;16:407-418. Epub 2019 Apr 6.

The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China; Shanghai Key Laboratory of Embryo Original Diseases, Shanghai 200030, China; Shanghai Municipal Key Clinical Speciality, Shanghai 20030, China. Electronic address:

Premature ovarian failure (POF) is one of the most common complications among female patients with tumors treated with chemotherapy and requires advanced treatment strategies. Human amniotic epithelial cell (hAEC)-based therapy mediates tissue regeneration in a variety of diseases, and increasing evidence suggests that the therapeutic efficacy of hAECs mainly depends on paracrine action. This study aimed to identify exosomes derived from hAECs and explored the therapeutic potential in ovaries damaged by chemotherapy and the underlying molecular mechanism. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S21622531193006
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http://dx.doi.org/10.1016/j.omtn.2019.03.008DOI Listing
April 2019
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Kaempferol protects lipopolysaccharide-induced inflammatory injury in human aortic endothelial cells (HAECs) by regulation of miR-203.

Biomed Pharmacother 2019 Apr 22;115:108888. Epub 2019 Apr 22.

Hypertension Department, Henan Provincial People's Hospital, Zhengzhou, 450003, China. Electronic address:

Background/aims: Hypertension is a common public health problem due to its high morbidity and potential risk, which is related to inflammatory actions. Kaempferol (KAE) has anti-inflammation activities. Herein, we explored the effects of KAE on LPS-induced inflammatory injury in human aortic endothelial cells (HAECs). Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108888DOI Listing

Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience.

Eur J Cancer 2019 Apr 22;114:27-35. Epub 2019 Apr 22.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

Purpose: Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive paediatric brain tumour with fatal outcome. The Individualised Therapy For Relapsed Malignancies In Childhood (INFORM) registry study offers comprehensive molecular profiling of high-risk tumours to identify target alterations for potential precision therapy. We analysed molecular characteristics and clinical data after brainstem biopsy of all enrolled newly diagnosed DIPGs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09598049193022
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http://dx.doi.org/10.1016/j.ejca.2019.03.019DOI Listing
April 2019
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Regional, socioeconomic and behavioural- impacts on consumer acceptability of beef in Northern Ireland, Republic of Ireland and Great Britain.

Meat Sci 2019 Apr 10;154:86-95. Epub 2019 Apr 10.

University College Cork, School of Food & Nutritional Sciences, Cork, Ireland.

This study was commissioned to assess if there are regional differences in the acceptability of beef between consumers from Northern Ireland (NI), Republic of Ireland (ROI) and Great Britain (GB). Palatability traits were affected by socioeconomic and behavioural factors such as preferred cooking endpoint, animal welfare, value, health aspects of beef product, ease of preparation as well as consumption frequency for specific cuts. "Willingness to pay" (WTP) was influenced by income, preferred cooking endpoint, value of beef product, ease of preparation and consumption frequency for frying steak. Read More

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http://dx.doi.org/10.1016/j.meatsci.2019.04.009DOI Listing

Management of critical events in the operating room: Usefulness of implementing a cognitive aid on the knowledge and satisfaction in French health-care providers.

J Clin Anesth 2019 Apr 22;58:7-8. Epub 2019 Apr 22.

Département d'Anesthésie Réanimation, Centre Hospitalier Universitaire de Toulouse, University Toulouse 3-Paul Sabatier, Toulouse, France; Department of Anesthesia, University of Toronto, Toronto, Ontario M5S 3E2, Canada.

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http://dx.doi.org/10.1016/j.jclinane.2019.04.020DOI Listing

Micro-geographic targeting for precision public policy: Analysis of child sex ratio across 587,043 census villages in India, 2011.

Health Place 2019 Apr 22;57:92-100. Epub 2019 Apr 22.

Harvard Center for Population and Development Studies, Cambridge, MA, USA; Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address:

Child sex ratio (CSR) is a marker of disproportionate sex ratio at birth and discriminatory practices that lead to differential survival in early childhood by sex. We used the 2011 Census on rural India to present the first local analysis of CSR across 587,043 villages. In our multilevel analysis considering villages, tehsils, districts, and states/union territories, we found 96% of the total variation in CSR to be attributed to villages. Read More

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http://dx.doi.org/10.1016/j.healthplace.2019.02.005DOI Listing

Coming 'Home': Place bonding for parents accessing or considering hospice based respite.

Health Place 2019 Apr 22;57:101-106. Epub 2019 Apr 22.

De Montfort University, Leicester, Leicestershire, LE1 9BH, UK. Electronic address:

Little literature examines the cognitive journey taken by parents considering/receiving hospice care for their child. A constructivist grounded theory study explored 38 parents' views of considering/using a children's hospice. Data analysed from focus groups and interviews identified three main concepts. Read More

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http://dx.doi.org/10.1016/j.healthplace.2019.03.004DOI Listing

Interventions involving a major dietary component improve cognitive function in cognitively healthy adults: a systematic review and meta-analysis.

Nutr Res 2019 Mar 14;66:1-12. Epub 2019 Mar 14.

Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA; Global Brain Health Institute, University of California San Francisco, San Francisco, CA, USA; Departments of Neurology, and Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA; San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.

Accumulating evidence suggests a role for diet in promoting brain health. The purpose of this systematic review was to (1) quantitatively assess whether interventions with a major dietary component can enhance cognition in cognitively healthy adults and (2) identify responsive domains of cognition to inform the design of future dietary trials. Electronic databases were systematically searched to find eligible randomized controlled trials that assessed the effect of interventions with a major dietary component on cognitive function or incident dementia in adults without known cognitive impairment. Read More

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http://dx.doi.org/10.1016/j.nutres.2019.02.008DOI Listing

Localized delivery of immunosuppressive regulatory T cells to peripheral nerve allografts promotes regeneration of branched segmental defects.

Biomaterials 2019 Apr 17;209:1-9. Epub 2019 Apr 17.

University of Wyoming, School of Pharmacy, Laramie, WY, 82071, USA. Electronic address:

Segmental injuries to peripheral nerves (PNs) too often result in lifelong disability or pain syndromes due to a lack of restorative treatment options. For injuries beyond a critical size, a bridging device must be inserted to direct regeneration. PN allografts from immunologically incompatible donors are highly effective bridging devices but are not a regular clinical option because of the expense and health risks of systemic immunosuppression (ISN). Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.04.015DOI Listing
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