4,302,642 results match your criteria Health & Place [Journal]


Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder.

Neuropsychopharmacology 2019 Feb 16. Epub 2019 Feb 16.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.

Recent European genome-wide association studies (GWAS) have revealed strong statistical correlations between MDD and numerous zero-to-high linked variants in the genomic region containing major histocompatibility complex (MHC) genes (MHC region), but the underlying molecular mechanisms are still unclear. To better understand the roles of this genomic region in the neurobiology of MDD, we applied a convergent functional genomics approach to integrate GWAS data of MDD relevant biological phenotypes, gene-expression analyses results obtained from brain samples, and genetic analyses of independent Chinese MDD samples. We observed that independent MDD risk variants in the MHC region were also significantly associated with the relevant biological phenotypes in the predicted directions, including the emotional and cognitive-related phenotypes. Read More

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http://dx.doi.org/10.1038/s41386-019-0346-3DOI Listing
February 2019

Neurological recovery following traumatic spinal cord injury: a systematic review and meta-analysis.

J Neurosurg Spine 2019 Feb 15:1-17. Epub 2019 Feb 15.

1Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences.

OBJECTIVEPredicting neurological recovery following traumatic spinal cord injury (TSCI) is a complex task considering the heterogeneous nature of injury and the inconsistency of individual studies. This study aims to summarize the current evidence on neurological recovery following TSCI by use of a meta-analytical approach, and to identify injury, treatment, and study variables with prognostic significance.METHODSA literature search in MEDLINE and EMBASE was performed, and studies reporting follow-up changes in American Spinal Injury Association (ASIA) Impairment Scale (AIS) or Frankel or ASIA motor score (AMS) scales were included in the meta-analysis. Read More

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http://dx.doi.org/10.3171/2018.10.SPINE18802DOI Listing
February 2019

Improved survival of glioblastoma patients treated at academic and high-volume facilities: a hospital-based study from the National Cancer Database.

J Neurosurg 2019 Feb 15:1-12. Epub 2019 Feb 15.

1The Vivian L. Smith Department of Neurosurgery, The University of Texas Health Science Center at Houston McGovern Medical School.

OBJECTIVEThe present study was designed to explore the association between facility type (academic center [AC] vs non-AC), facility volume (high-volume facility [HVF] vs low-volume facility [LVF]), and outcomes of glioblastoma (GBM) treatment.METHODSBased on the National Cancer Database (NCDB), GBM patients were categorized by treatment facility type (non-AC vs AC) and volume [4 categories (G1-G4): < 5.0, 5. Read More

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http://dx.doi.org/10.3171/2018.10.JNS182247DOI Listing
February 2019

Impact of decompression surgery without fusion for lumbar spinal stenosis on sagittal spinopelvic alignment: minimum 2-year follow-up.

J Neurosurg Spine 2019 Feb 15:1-7. Epub 2019 Feb 15.

1Department of Orthopaedic Surgery, Japanese Red Cross Shizuoka Hospital, Shizuoka, Japan; and.

OBJECTIVEThe importance of global sagittal alignment is well known. Patients with lumbar spinal stenosis (LSS) generally tend to bend forward to relieve their neurological symptoms, i.e. Read More

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http://dx.doi.org/10.3171/2018.11.SPINE181092DOI Listing
February 2019

Encore careers: a solution to the unmet need in global neurosurgical care.

J Neurosurg 2019 Feb 15:1-3. Epub 2019 Feb 15.

3George Washington University School of Medicine and Health Sciences, Washington, DC.

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http://dx.doi.org/10.3171/2018.11.JNS183298DOI Listing
February 2019

Correlation of perioperative risk scores with hospital costs in neurosurgical patients.

J Neurosurg 2019 Feb 15:1-7. Epub 2019 Feb 15.

2Department of Neurosurgery, University of Florida, Gainesville, Florida.

OBJECTIVEThe American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) online surgical risk calculator uses inherent patient characteristics to provide predictive risk scores for adverse postoperative events. The purpose of this study was to determine if predicted perioperative risk scores correlate with actual hospital costs.METHODSA single-center retrospective review of 1005 neurosurgical patients treated between September 1, 2011, and December 31, 2014, was performed. Read More

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http://dx.doi.org/10.3171/2018.10.JNS182041DOI Listing
February 2019

Spondylodiscitis in end-stage renal disease: a systematic review.

J Neurosurg Spine 2019 Feb 15:1-9. Epub 2019 Feb 15.

1Department of Neurological Surgery, University of Miami, Miami, Florida; and.

OBJECTIVEDiscitis and osteomyelitis are seen in end-stage renal disease (ESRD) patients due to repeated vascular access for hemodialysis and urinary tract infections leading to recurrent bacteremia. Discitis and osteomyelitis are underdiagnosed due to the nonspecific initial presentation of back pain. In this article, we review the literature for better understanding of the problem and the importance of early diagnosis by primary care physicians and nephrologists. Read More

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http://dx.doi.org/10.3171/2018.9.SPINE18824DOI Listing
February 2019

Locating the foramen ovale by using molar and inter-eminence planes: a guide for percutaneous trigeminal neuralgia procedures.

J Neurosurg 2019 Feb 15:1-7. Epub 2019 Feb 15.

Departments of1Natural Sciences and Mathematics and.

OBJECTIVEThe first attempt to cannulate the foramen ovale is oftentimes unsuccessful and requires subsequent reattempts, thereby increasing the risk of an adverse event and radiation exposure to the patient and surgeon. Failure in cannulation may be attributable to variation in soft-tissue-based landmarks used for needle guidance. Also, the incongruity between guiding marks on the face and bony landmarks visible on fluoroscopic images may also complicate cannulation. Read More

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http://dx.doi.org/10.3171/2018.11.JNS182276DOI Listing
February 2019

Rear Admiral (Astronaut) Alan Shepard: Ménière's disease and the race to the moon.

J Neurosurg 2019 Feb 15:1-7. Epub 2019 Feb 15.

6Department of Neurosurgery, University of South Alabama, Mobile, Alabama.

On May 5, 1961, Alan B. Shepard Jr. piloted the Freedom 7 craft into a suborbital flight to become the first American man in space. Read More

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http://dx.doi.org/10.3171/2018.9.JNS182522DOI Listing
February 2019

Leptomeningeal dissemination: a sinister pattern of medulloblastoma growth.

J Neurosurg Pediatr 2019 Feb 15:1-9. Epub 2019 Feb 15.

3Cancer Research Program, Research Institute of the McGill University Health Center and Department of Surgery, McGill University, Montreal, Quebec, Canada.

Leptomeningeal dissemination (LMD) is the defining pattern of metastasis for medulloblastoma. Although LMD is responsible for virtually 100% of medulloblastoma deaths, it remains the least well-understood part of medulloblastoma pathogenesis. The fact that medulloblastomas rarely metastasize outside the CNS but rather spread almost exclusively to the spinal and intracranial leptomeninges has fostered the long-held belief that medulloblastoma cells spread directly through the CSF, not the bloodstream. Read More

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http://dx.doi.org/10.3171/2018.11.PEDS18506DOI Listing
February 2019

Pontine tumor in a neonate: case report and analysis of the current literature.

J Neurosurg Pediatr 2019 Feb 15:1-7. Epub 2019 Feb 15.

1Pediatric Hematology and Oncology, Goethe University; Departments of.

Tumors of the central nervous system represent the largest group of solid tumors found in pediatric patients. Pilocytic astrocytoma is the most common pediatric glioma, mostly located in the posterior fossa. The majority of brainstem tumors, however, are classified as highly aggressive diffuse intrinsic pontine gliomas (DIPGs) and their prognosis is dismal. Read More

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http://dx.doi.org/10.3171/2018.10.PEDS18215DOI Listing
February 2019

Adverse events and their risk factors 90 days after cervical spine surgery: analysis from the Michigan Spine Surgery Improvement Collaborative.

J Neurosurg Spine 2019 Feb 15:1-13. Epub 2019 Feb 15.

Departments of1Neurosurgery.

OBJECTIVEThe Michigan Spine Surgery Improvement Collaborative (MSSIC) is a statewide, multicenter quality improvement initiative. Using MSSIC data, the authors sought to identify 90-day adverse events and their associated risk factors (RFs) after cervical spine surgery.METHODSA total of 8236 cervical spine surgery cases were analyzed. Read More

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http://dx.doi.org/10.3171/2018.10.SPINE18666DOI Listing
February 2019

Validation of a methodology for neuro-urological and lumbosacral stimulation studies in domestic pigs: a humanlike animal model.

J Neurosurg Spine 2019 Feb 15:1-11. Epub 2019 Feb 15.

7Neurosurgery, Pellegrin Hospital, Bordeaux, Nouvelle Aquitaine; and.

OBJECTIVESpinal cord injuries (SCIs) result in loss of movement and sensory feedback, but also organ dysfunction. Nearly all patients with complete SCI lose bladder control and are prone to kidney failure if intermittent catheterization is not performed. Electrical stimulation of sacral spinal roots was initially considered to be a promising approach for restoring continence and micturition control, but many patients are discouraged by the need for surgical deafferentation as it could lead to a loss of sensory functions and reflexes. Read More

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http://dx.doi.org/10.3171/2018.11.SPINE18676DOI Listing
February 2019

Brain-derived neurotrophic factor DNA methylation mediates the association between neighborhood disadvantage and adolescent brain structure.

Psychiatry Res Neuroimaging 2018 Dec 24;285:51-57. Epub 2018 Dec 24.

Melbourne Neuropsychiatry Center, Department of Psychiatry, The University of Melbourne and Melbourne Health, Parkville, Victoria, Australia; Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Victoria, Australia. Electronic address:

Prior research indicates that socioeconomic disadvantage is associated with prefrontal cortical (PFC) development in childhood and adolescence, however the mechanisms of this link are unclear. This study investigated whether DNA methylation of the brain-derived neurotrophic factor (BDNF, which plays a key role in synaptic plasticity), mediated the association between neighborhood disadvantage and thickness of the PFC in adolescents. Neighborhood disadvantage was measured in 33 adolescents aged 12-13 years using the Socio-Economic Indexes for Areas. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2018.12.012DOI Listing
December 2018

Perceptions of the possible impact of dyslexia on nursing and midwifery students and of the coping strategies they develop and/or use to help them cope in clinical practice.

Authors:
Anna T Crouch

Nurse Educ Pract 2019 Jan 4;35:90-97. Epub 2019 Jan 4.

The University of Northampton, Faculty of Health and Society, Waterside Campus, University Drive, Northampton, NN1 5PH, United Kingdom. Electronic address:

This qualitative grounded theory case study aimed to explore the perceptions of the impact of dyslexia on nursing and midwifery students and of the coping strategies they develop and/or use to help them cope in practice. The questions addressed were: 1. What is the perceived impact of dyslexia on the nursing and midwifery student in clinical practice? 2. Read More

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http://dx.doi.org/10.1016/j.nepr.2018.12.008DOI Listing
January 2019

Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep.

Redox Biol 2019 Jan 29;22:101128. Epub 2019 Jan 29.

Programa de Fisiopatología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Av. Salvador 486, Providencia 7500922, Santiago, Chile; International Center for Andean Studies (INCAS), Universidad de Chile, Baquedano s/n, Putre, Chile. Electronic address:

Chronic hypobaric hypoxia during fetal and neonatal life induces neonatal pulmonary hypertension. Hypoxia and oxidative stress are driving this condition, which implies an increase generation of reactive oxygen species (ROS) and/or decreased antioxidant capacity. Melatonin has antioxidant properties that decrease oxidative stress and improves pulmonary vascular function when administered postnatally. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101128DOI Listing
January 2019

Associations of blood levels of trace elements and heavy metals with metabolic syndrome in Chinese male adults with microRNA as mediators involved.

Environ Pollut 2019 Feb 6;248:66-73. Epub 2019 Feb 6.

Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, PR China. Electronic address:

Metabolic syndrome (MetS) is a global health problem with an increasing prevalence. However, effects of trace elements and heavy metals on MetS and the mechanism underlying this effect are poorly understood. A preliminary cross-sectional study was conducted in 2015. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.02.015DOI Listing
February 2019

Changes in blood pressure associated with lead, manganese, and selenium in a Bangladeshi cohort.

Environ Pollut 2019 Feb 7;248:28-35. Epub 2019 Feb 7.

Division of Epidemiology and Biostatistics, University of Illinois at Chicago, School of Public Health, Chicago, IL, USA. Electronic address:

Background: Heavy metal contamination is widespread in Bangladesh. Previous studies have observed lead increases blood pressure over time. However, the role of other metal contaminants and essential micronutrients, which could also adversely affect blood pressure or act as protective factors, is understudied. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.01.129DOI Listing
February 2019

The value of delta neutrophil index in neonatal sepsis diagnosis, follow-up and mortality prediction.

Early Hum Dev 2019 Feb 13;131:6-9. Epub 2019 Feb 13.

Division of Neonatology, Department of Pediatrics, University of Health Sciences, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, 06010, Ankara, Turkey; Division of Neonatology, Department of Pediatrics, Yildirim Beyazit University, 06800, Ankara, Turkey.

Background: The complete blood cell count (CBC) and peripheral blood smear were the most commonly ordered tests for the diagnosis of neonatal sepsis. Delta neutrophil index (DNI) shows leucocyte differentiation and calculated while CBC is performed.

Aims: We aimed to evaluate the value of DNI in neonatal sepsis. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2019.02.003DOI Listing
February 2019

Host's immune response in unresponsive and responsive patients with anthroponotic cutaneous leishmaniasis treated by meglumine antimoniate: A case-control study of Th1 and Th2 pathways.

Int Immunopharmacol 2019 Feb 13;69:321-327. Epub 2019 Feb 13.

Dadbin Health Clinic, Kerman University of Medical Sciences, Kerman, Iran.

The objective of the present study was to compare the host's immune responses between unresponsive and responsive patients with anthroponotic cutaneous leishmaniasis (ACL) treated by meglumine antimoniate. A case-control study was carried out in an endemic focus in Iran. Blood samples were taken from patients and peripheral blood mononuclear cells (PBMCs) were isolated. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.02.008DOI Listing
February 2019

Long non-coding RNA activated by transforming growth factor beta alleviates lipopolysaccharide-induced inflammatory injury via regulating microRNA-223 in ATDC5 cells.

Int Immunopharmacol 2019 Feb 13;69:313-320. Epub 2019 Feb 13.

Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin, China. Electronic address:

Osteoarthritis (OA) is a conversant joint disease, which seriously threatens the health of the elderly, and even leads to disability. Long non-coding RNA-activated by transforming growth factor beta (lncRNA-ATB) has been reported in diverse cancers. However, the functions of lncRNA-ATB in OA remain uninvestigated. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.01.056DOI Listing
February 2019

Adjuvant androgen deprivation therapy for poor-risk, androgen receptor-positive salivary duct carcinoma.

Eur J Cancer 2019 Feb 13;110:62-70. Epub 2019 Feb 13.

Department of Medical Oncology, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, the Netherlands. Electronic address:

Aim: Salivary duct carcinoma (SDC), an aggressive subtype of salivary gland cancer, is androgen receptor (AR)-positive in 67-96% of cases. In patients with locally recurrent and metastatic (R/M) AR-positive SDC, androgen deprivation therapy (ADT) has an overall response rate of 18-64.7%. Read More

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http://dx.doi.org/10.1016/j.ejca.2018.12.035DOI Listing
February 2019

A randomized, double-blind, placebo-controlled trial to assess the efficAcy and safety of Trimetazidine in patients with angina pectoris having been treated by percutaneous coronary intervention (ATPCI study): Rationale, design, and baseline characteristics.

Am Heart J 2019 Jan 15;210:98-107. Epub 2019 Jan 15.

Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou (HEGP), Department of Cardiology, Paris, France; Université Paris-Descartes, Paris, France; INSERM U-970, Paris, France.

Background: About 30% of angina patients have persisting symptoms despite successful revascularization and antianginal therapy. Moreover, in stable patients, percutaneous coronary intervention (PCI) does not improve survival as compared with medical therapy alone. Trimetazidine, an antianginal agent devoid of hemodynamic effect, may help reducing symptoms and improving outcomes after PCI. Read More

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http://dx.doi.org/10.1016/j.ahj.2018.12.015DOI Listing
January 2019

Marital quality, partner's engagement and continuous positive airway pressure adherence in obstructive sleep apnea.

Sleep Med 2018 Dec 26;55:56-61. Epub 2018 Dec 26.

HP2 Laboratory, INSERM U1042, Univ. Grenoble Alpes, Grenoble, France; EFCR Laboratory, Grenoble Alpes University Hospital, Grenoble, France. Electronic address:

Background: Continuous positive airway pressure (CPAP) is the first line therapy for obstructive sleep apnea (OSA) but its effectiveness requires high adherence. We aimed to assess the impacts of the spouse's/partner's involvement and the quality of the couple's relationship on CPAP adherence.

Methods: In a multicenter prospective study conducted in France, patients reported their subjective views regarding their partner's engagement in their CPAP treatment and the quality of their marital relationship using the Quality of Marriage Index. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.12.009DOI Listing
December 2018

Dietary supplementation with strawberry induces marked changes in the composition and functional potential of the gut microbiome in diabetic mice.

J Nutr Biochem 2019 Jan 18;66:63-69. Epub 2019 Jan 18.

Department of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT 84112, USA. Electronic address:

Gut microbiota contributes to the biological activities of berry anthocyanins by transforming them into bioactive metabolites, and anthocyanins support the growth of specific bacteria, indicating a two-way relationship between anthocyanins and microbiota. In the present study, we tested the hypothesis that strawberry supplementation alters gut microbial ecology in diabetic db/db mice. Control (db/+) and diabetic (db/db) mice (7 weeks old) consumed standard diet or diet supplemented with 2. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2019.01.004DOI Listing
January 2019

Inadequate prenatal care utilization among women with and without methadone-treated opioid use disorders in Taiwan.

Int J Drug Policy 2019 Feb 13;67:1-8. Epub 2019 Feb 13.

Children and Family Research Center, National Taiwan University, Taipei, Taiwan.

Aims: The present study aims to investigate the utilization pattern of prenatal care and correlates for women with opioid use disorders (OUD) in Taiwan.

Method: Using the data linkage between the Methadone Maintenance Treatment (MMT) register with national health insurance, national birth notification system, and birth registration system, we identified 1712 pregnancies with 20 or more gestational weeks from women enrolled in the MMT (heroin-exposed: receiving no methadone treatment during pregnancy, n = 1053 by 882 women; methadone-treated: receiving methadone for at least one day during pregnancy, n = 659 by 574 women) and their 1:10 matched pregnancies from 17,060 women without substance use disorder in the period of 2004-2013. The generalized linear mixed models with negative binomial and logit distributions were performed to evaluate the relationship between individual sociodemographic, health, and addiction treatment characteristics with the number of prenatal visits and receiving prenatal care in the first trimester (i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09553959193003
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http://dx.doi.org/10.1016/j.drugpo.2019.01.024DOI Listing
February 2019
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Recent advances of anti-cancer therapies including the use of cell-penetrating peptides.

Curr Opin Pharmacol 2019 Feb 13;47:8-13. Epub 2019 Feb 13.

University of Cologne, Department of Chemistry, Biochemistry, Zülpicher Str. 47a, 50674 Cologne, Germany. Electronic address:

Cancer is one of the major growing public health problems making the development of new anti-cancer treatment strategies still compulsory. Conventionally used chemotherapies are quite often associated with severe side effects. One reason is limited cell-permeability of the used drugs resulting in only poor overall bioavailability. Read More

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http://dx.doi.org/10.1016/j.coph.2019.01.003DOI Listing
February 2019

Subthalamic and pallidal oscillatory activity in patients with Neurodegeneration with Brain Iron Accumulation type I (NBIA-I).

Clin Neurophysiol 2019 Jan 25;130(4):469-473. Epub 2019 Jan 25.

Department of Neurology, Charité - Universitätsmedizin Berlin, Germany; NeuroCure, ExzellenzCluster, Charité - Universitätsmedizin Berlin, Germany; Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Germany. Electronic address:

Objectives: Neurodegeneration with Brain Iron Accumulation type I (NBIA-I) is a rare hereditary neurodegenerative disorder with pallidal degeneration leading to disabling generalized dystonia and parkinsonism. Pallidal or subthalamic deep brain stimulation can partially alleviate motor symptoms. Disease-specific patterns of abnormally enhanced oscillatory neuronal activity recorded from the basal ganglia have been described in patients with movement disorders undergoing deep brain stimulation (DBS). Read More

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http://dx.doi.org/10.1016/j.clinph.2018.12.012DOI Listing
January 2019

Differences between flexion and extension synergy-driven coupling at the elbow, wrist, and fingers of individuals with chronic hemiparetic stroke.

Clin Neurophysiol 2019 Jan 31;130(4):454-468. Epub 2019 Jan 31.

Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, USA; Department of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address:

Objective: The flexion and extension synergies were quantified at the paretic elbow, forearm, wrist, and finger joints within the same group of participants for the first time. Differences in synergy expression at each of the four joints were examined, as were the ways these differences varied across the joints.

Methods: Twelve post-stroke individuals with chronic moderate-to-severe hemiparesis and six age-matched controls participated. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.010DOI Listing
January 2019

Economic sanctions threaten population health: the case of Iran.

Public Health 2019 Feb 13;169:10-13. Epub 2019 Feb 13.

Department of Finance, NEOMA Business School, France.

Objective: The aim of the study is to review evidence of the negative consequences of international economic sanctions on population health in Iran and pathways via which the sanctions affect health.

Study Design: This is a narrative review.

Methods: Data from the World Bank and the Central Bank of Iran were gathered to clarify economic consequences of sanctions. Read More

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http://dx.doi.org/10.1016/j.puhe.2019.01.006DOI Listing
February 2019

Exploring socio-economic inequalities in the use of medicines: is the relation mediated by health status?

Public Health 2019 Feb 13;169:1-9. Epub 2019 Feb 13.

LMU Munich, University Hospital, Department of Psychiatry and Psychotherapy, Nußbaumstr. 7, 80336 Munich, Germany. Electronic address:

Objectives: This study evaluated mediating effects of the health status on the association between socio-economic status (SES) and medicine use. It was hypothesized that more privileged people show a reduced use of medicines, as compared with the underprivileged, because of their superior health status. It was further hypothesized that people may apply medication based on their type of health complaint (ill physical versus mental status). Read More

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http://dx.doi.org/10.1016/j.puhe.2018.12.018DOI Listing
February 2019

Prognostic effect of serum BDNF levels in late-life depression: Moderated by childhood trauma and SSRI usage?

Psychoneuroendocrinology 2019 Feb 7;103:276-283. Epub 2019 Feb 7.

University of Groningen, University Medical Center Groningen, Department of Psychiatry, University of Groningen PO Box 72, 9700 AB, Groningen, the Netherlands.

Background: Brain-derived neurotrophic factor (BDNF) levels decline during depression and normalise after remission, although studies in older patient samples are inconsistent. Whether BDNF serum levels predict depression remission is unclear. We hypothesize that the predictive value of serum BDNF levels in late-life depression is moderated by selective serotonin reuptake inhibitors (SSRI) usage and early traumatization. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.02.003DOI Listing
February 2019

Decay rates of Escherichia coli, Enterococcus spp., F-specific bacteriophage MS2, somatic coliphage and human adenovirus in facultative pond sludge.

Water Res 2019 Feb 1;154:62-71. Epub 2019 Feb 1.

Molecular and Life Sciences, Curtin University, GPO Box U1987 Perth, Western Australia, 6845, Australia. Electronic address:

The purpose of this study was to evaluate the efficacy of a waste stabilization pond (WSP) system to reduce pathogen contaminants in sludge. This included examining the factors that influence the fate and concentration of human pathogens and their indicators in two sludge layers. The decay rates of five study microorganisms were determined under in-situ conditions at a WSP. Read More

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http://dx.doi.org/10.1016/j.watres.2019.01.027DOI Listing
February 2019

Data fitting approach more critical than exposure scenarios and treatment of censored data for quantitative microbial risk assessment.

Water Res 2019 Feb 4;154:45-53. Epub 2019 Feb 4.

Instituto de Investigaciones para la Industria Química (INIQUI), CONICET, Universidad Nacional de Salta (UNSa), Av. Bolivia 5150, Salta, 4400, Argentina; Singapore Centre for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, 637551, Singapore; Facultad de Ingeniería, UNSa, Salta, Argentina. Electronic address:

Recreational waters are a source of many diseases caused by human viral pathogens, including norovirus genogroup II (NoV GII) and enterovirus (EV). Water samples from the Arenales river in Salta, Argentina, were concentrated by ultrafiltration and analyzed for the concentrations of NoV GII and EV by quantitative PCR. Out of 65 samples, 61 and 59 were non-detects (below the Sample Limit of Detection limit, SLOD) for EV and NoV GII, respectively. Read More

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http://dx.doi.org/10.1016/j.watres.2019.01.041DOI Listing
February 2019

Direct and indirect effects of perception on generalization gradients.

Behav Res Ther 2019 Jan 18;114:44-50. Epub 2019 Jan 18.

Center for the Psychology of Learning and Experimental Psychopathology, Faculty of Psychology and Educational Sciences, KU Leuven, Tiensestraat 102, Box 3712, 3000, Leuven, Belgium.

For more than a century, researchers have attempted to understand why organisms behave similarly across situations. Despite the robust character of generalization, considerable variation in conditioned responding both between and within humans remains a challenge for contemporary generalization models. The current study aims to investigate the extent to which variation in behavior in a context of generalization can be attributed to differences in perception. Read More

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http://dx.doi.org/10.1016/j.brat.2019.01.006DOI Listing
January 2019

Temporal and geographical variations in colorectal cancer incidence in Northern Iran 2004-2013.

Cancer Epidemiol 2019 Feb 13;59:143-147. Epub 2019 Feb 13.

Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Genetic Epidemiology Group, Folkhälsan Research Center, Faculty of Medicine, Helsinki University, Helsinki, Finland; Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.

Introduction: Colorectal cancer (CRC) is one of the most common cancers in the Golestan province, Northern Iran. The purpose of this study is to describe colorectal cancer incidence patterns and trends in the province 2004-2013.

Methods: Data on CRC cases were obtained from the Golestan Population-based Cancer Registry (GPCR). Read More

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http://dx.doi.org/10.1016/j.canep.2019.02.003DOI Listing
February 2019

Contemporary trends of pelvic lymph node dissection at radical cystectomy for urothelial carcinoma of urinary bladder and associated cancer specific mortality and complications: comparison between octogenarian versus younger patients.

Cancer Epidemiol 2019 Feb 13;59:135-142. Epub 2019 Feb 13.

Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Québec, Canada; Division of Urology, University of Montreal Hospital Center (CHUM), Montreal, Quebec, Canada.

Background: We analysed contemporary pelvic lymph node dissection (PLND) trend during radical cystectomy (RC) for urothelial carcinoma of urinary bladder (UCUB), as well as PLND association with cancer specific mortality (CSM) and complications after stratification according to octogenarian vs. younger age.

Materials And Methods: Within the SEER and NIS databases, respectively 10,427 (T2 and T3 stages) and 19,203 (all T-stages) RC patients (2004-2015) for UCUB were identified. Read More

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http://dx.doi.org/10.1016/j.canep.2019.02.002DOI Listing
February 2019

Pumping the brakes: suppression of synapse development by MDGA-neuroligin interactions.

Curr Opin Neurobiol 2019 Feb 13;57:71-80. Epub 2019 Feb 13.

Djavad Mowafaghian Centre for Brain Health and Department of Psychiatry, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada. Electronic address:

Synapse development depends on a dynamic balance between synapse promoters and suppressors. MDGAs, immunoglobulin superfamily proteins, negatively regulate synapse development through blocking neuroligin-neurexin interactions. Recent analyses of MDGA-neuroligin complexes revealed the structural basis of this activity and indicate that MDGAs interact with all neuroligins with differential affinities. Read More

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http://dx.doi.org/10.1016/j.conb.2019.01.002DOI Listing
February 2019

Worldwide variation in Pseudomonas associated ventilator associated pneumonia. A meta-regression.

Authors:
James C Hurley

J Crit Care 2019 Feb 6;51:88-93. Epub 2019 Feb 6.

Department of Rural Health, Melbourne Medical School, University of Melbourne, Internal Medicine Service, Ballarat Health Services, Victoria, Australia. Electronic address:

Purpose: The objective here is to define the extent and possible reasons for geographic variation in Pseudomonas aeruginosa associated with Ventilator Associated Pneumonia (VAP).

Methods: A random effects meta-regression model of Pseudomonas associated VAP incidence within the published literature was undertaken incorporating group level factors such trauma admission, year of publication and use of bronchoscopic sampling towards VAP diagnosis.

Results: Pseudomonas associated VAP incidence was reported in 162 studies from seven worldwide regions published over 30 years. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.001DOI Listing
February 2019

Synthesis, neuroprotective and antioxidant capacity of PBN-related indanonitrones.

Bioorg Chem 2019 Feb 1;86:445-451. Epub 2019 Feb 1.

Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain. Electronic address:

In this work six PBN-related indanonitrones 1-6 have been designed, synthesized, and their neuroprotection capacity tested in vitro, under OGD conditions, in SH-SY5Y human neuroblastoma cell cultures. As a result, we have identified indanonitrones 1, 3 and 4 (EC = 6.64 ± 0. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.01.071DOI Listing
February 2019

Intrahepatic Delivery of Pegylated Catalase Is Protective in a Rat Ischemia/Reperfusion Injury Model.

J Surg Res 2019 Feb 13;238:152-163. Epub 2019 Feb 13.

The COPPER Laboratory, The Ohio State University Wexner Medical Center, Columbus, Ohio; Comprehensive Transplant Center, The Ohio State University Wexner Medical Center, Columbus, Ohio; Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio. Electronic address:

Background: Ischemia/reperfusion injury (IRI) can occur during liver surgery. Endogenous catalase is important to cellular antioxidant defenses and is critical to IRI prevention. Pegylation of catalase (PEG-CAT) improves its therapeutic potential by extending plasma half-life, but systemic administration of exogenous PEG-CAT has been only mildly therapeutic for hepatic IRI. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.028DOI Listing
February 2019

SELDI-TOF MS Analysis of Hepatocellular Carcinoma in an Australian Cohort.

J Surg Res 2019 Feb 13;238:127-136. Epub 2019 Feb 13.

Cancer Surgery and Metabolism Research Group, University of Sydney, Kolling Institute of Medical Research, St Leonards, NSW, Australia; Upper GI Surgical Unit, Royal North Shore Hospital and North Shore Private Hospital, St Leonards, NSW, Australia; Discipline of Surgery, The University of Sydney, Camperdown, NSW, Australia.

Background: Hepatocellular carcinoma (HCC) is a common cause of cancer death worldwide. Resection offers the best chance of long-term survival, but a consistent adverse prognostic factor is the presence of microvascular invasion (MVI). In this study, surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS), a high throughput method of analyzing complex samples, was used to explore differentially expressed proteins between HCC and adjacent nontumour liver tissue (ANLT). Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.008DOI Listing
February 2019

Development of a scenario-based stormwater management planning support system for reducing combined sewer overflows (CSOs).

J Environ Manage 2019 Feb 13;236:571-580. Epub 2019 Feb 13.

U.S. Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory, Water Systems Division, Water Resources Recovery Branch, Cincinnati, OH, USA. Electronic address:

Using combined sewer systems to handle excess stormwater runoff is common in older urban areas. Combined sewer overflow (CSO) events occur when hydraulic capacity is exceeded, and untreated wastewater discharges to surface waters. As urban population density increases, and more demand is placed on infrastructure, CSO events happen more often and cause serious environmental problems and public-health risks. Read More

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http://dx.doi.org/10.1016/j.jenvman.2018.12.089DOI Listing
February 2019

Municipal reclaimed water for multi-purpose applications in the power sector: A review.

J Environ Manage 2019 Feb 13;236:561-570. Epub 2019 Feb 13.

The Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA; Stantec Consulting Services, Inc., 1101 14th Street NW Suite 1200, Washington, DC, 20005-5637, USA.

Wastewater and power utilities in the United States have an enormous opportunity to collaborate on the mutually beneficial uses of reclaimed water. Despite close proximity to wastewater facilities, only a limited number of power plants are currently using municipal reclaimed water for cooling tower and boiler applications. Through a review of the literature, this document aims at creating a more perspicuous understanding of the reuse of reclaimed water for power plant applications, particularly as pertains to those associated with cooling towers and boilers, by highlighting the drivers of current implementation, regulatory issues and treatment goals, and available treatment technologies. Read More

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http://dx.doi.org/10.1016/j.jenvman.2018.10.102DOI Listing
February 2019

Perpetration of sexual aggression among adolescents in South Africa.

J Adolesc 2019 Feb 13;72:32-36. Epub 2019 Feb 13.

Department of Psychiatry and Mental Health, Alpert Medical School of Brown University; Providence/Boston Center for AIDS Research, USA.

Introduction: In South Africa, one in three men have reported perpetrating rape. Adolescence presents a unique developmental period for primary prevention of violence. However, few studies characterize the epidemiology of sexual violence among adolescents in South Africa. Read More

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http://dx.doi.org/10.1016/j.adolescence.2019.02.002DOI Listing
February 2019

Adolescent men's attitudes and decision making in relation to pregnancy and pregnancy outcomes: An integrative review of the literature from 2010 to 2017.

J Adolesc 2019 Feb 12;72:23-31. Epub 2019 Feb 12.

Queen's University Belfast, School of Nursing and Midwifery, 97 Lisburn Rd, Belfast, BT9 7BL, UK. Electronic address:

Introduction: The review updates a previous review conducted in 2010 (Lohan et al.), summarizing the available literature on young men's attitudes and decision-making in the context of addressing two questions: (1) What are adolescent men's attitudes to adolescent pregnancy? (2) What are adolescent men's attitudes and decision-making in relation to pregnancy outcomes?

Methods: Using Whittemore and Knafl's process for conducting an integrative review, 38 studies published between 2010 and 2017 reporting on young men's attitudes and decision-making in relation to pregnancy and pregnancy outcomes were analysed.

Results: One of the most important conclusions of this review is that the findings of studies can often be contradictory. Read More

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http://dx.doi.org/10.1016/j.adolescence.2018.12.008DOI Listing
February 2019

Maternal employment and child health in Nepal: The importance of job type and timing across the child's first five years.

Soc Sci Med 2019 Feb 6;224:94-105. Epub 2019 Feb 6.

Population Studies Center, University of Michigan, 426 Thompson Street, P.O. Box 1248, Ann Arbor, MI, 48106-1248, USA; Institute for Social and Environmental Research Nepal, Bharatpur Metropolitan City, Ward No. 15, Chitwan, Nepal. Electronic address:

The increase in female labor force participation (FLFP) in the paid labor market since the mid-1900s is one of the most pronounced family transitions and increasingly a global phenomenon. While this may improve income and bargaining power of the women, it may also increase stress and decrease time with children. Using the Chitwan Valley Family Study in Nepal, we explore the consequences of this transition for children's health by combining newly collected data on child health outcomes, quarterly data on women's employment, and data on households and neighborhoods. Read More

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http://dx.doi.org/10.1016/j.socscimed.2019.02.009DOI Listing
February 2019

The hidden cost of informal care: An empirical study on female caregivers' subjective well-being.

Soc Sci Med 2019 Feb 7;224:85-93. Epub 2019 Feb 7.

Harold Walter Siebens School of Business, Buena Vista University, Storm Lake, IA, USA. Electronic address:

Using data from the China Health and Nutrition Survey (CHNS), this study investigated the impact of informal care on female caregivers' subjective well-being in China. We found that informal care significantly reduced the subjective well-being of female caregivers using the instrumental variable (IV) ordered probit model. Our results revealed that the care effect on subjective well-being was more significant for rural caregivers than for urban caregivers. Read More

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http://dx.doi.org/10.1016/j.socscimed.2019.01.051DOI Listing
February 2019

Migration regularity of six preservatives from wooden children's products to saliva and sweat based on microstructure-related migration models.

Ecotoxicol Environ Saf 2019 Feb 13;173:149-155. Epub 2019 Feb 13.

Institute of Industrial and Consumer Product Safety, Chinese Academy of Inspection and Quarantine, Beijing 100176, China.

Wood preservatives in wooden children's products (WCPs) may migrate into children's body through oral and dermal exposure, resulting in a potential health risk. In this paper, a systematic investigation on the migration regularity of lindane and five chlorophenols preservatives from WCPs to saliva and sweat was introduced. Migration models were established based on the abundant migration data among different time periods (2 min-96 h). Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.01.108DOI Listing
February 2019

Chronic exposure to microcystin-LR reduces thyroid hormone levels by activating p38/MAPK and MEK/ERK signal pathway.

Ecotoxicol Environ Saf 2019 Feb 13;173:142-148. Epub 2019 Feb 13.

Department of Geriatric Endocrinology, Geriatric Hospital of Nanjing Medical University, Luojia Road 30, Nanjing 210024, China. Electronic address:

Microcystin-LR (MC-LR) is the most toxic and abundant microcystin that produced by cyanobacteria. Previous studies have shown MC-LR had acute toxic to thyroid, however, the mechanism is still unclear, and the effect of long-term, low-dose MC-LR on thyroid remains uncertain. In this study, we investigated the chronic, low-dose effect of MC-LR on mouse thyroid tissues and thyroid hormone metabolism. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.02.024DOI Listing
February 2019
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