13,528 results match your criteria Headache Children

Arterolane-piperaquine-mefloquine versus arterolane-piperaquine and artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children: a single-centre, open-label, randomised, non-inferiority trial.

Lancet Infect Dis 2021 Jun 7. Epub 2021 Jun 7.

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Background: Triple antimalarial combination therapies combine potent and rapidly cleared artemisinins or related synthetic ozonides, such as arterolane, with two, more slowly eliminated partner drugs to reduce the risk of resistance. We aimed to assess the safety, tolerability, and efficacy of arterolane-piperaquine-mefloquine versus arterolane-piperaquine and artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in Kenyan children.

Methods: In this single-centre, open-label, randomised, non-inferiority trial done in Kilifi County Hospital, Kilifi, coastal Kenya, children with uncomplicated Plasmodium falciparum malaria were recruited. Read More

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Orbital neuromuscular choristoma of the ophthalmic nerve.

Eur J Ophthalmol 2021 Jun 10:11206721211024821. Epub 2021 Jun 10.

Department of Ophthalmology, Rio Hortega University Hospital, Valladolid, Spain.

Introduction: Neuromuscular choristoma (NC) is a rare tumor composed of striated muscle fibers admixed with nerve fibers that often affects large peripheral nerve trunks in children. To the best of our knowledge, this is the first reported case in the literature of a NC of the ophthalmic nerve in an adult.

Case Description: A 27-year-old woman presented with a 20-day history of left periorbital headache radiating to the frontotemporal region, with associated tearing, nausea, and vomiting. Read More

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Dihydroergotamine infusion for pediatric refractory headache: A retrospective chart review.

Headache 2021 May;61(5):777-789

Neuroscience Programs, Boston Children's Hospital, Boston, MA, USA.

Background: Headaches are a common symptom in children. Children with refractory headaches may be admitted for inpatient treatment with intravenous dihydroergotamine mesylate (DHE). However, very few studies have characterized these patients and their treatment outcomes using validated, self-reported, pain scales. Read More

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The status of intravenous dihydroergotamine for pediatric headache: Status migrainosus and beyond.

Kaitlin A Greene

Headache 2021 May;61(5):698-699

Doernbecher Children's Hospital Child & Adolescent Headache Program, Division of Pediatric Neurology, Oregon Health & Science University, Portland, OR, USA.

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Cerebral sinovenous thrombosis in children: A single-center experience.

Turk Arch Pediatr 2021 1;56(3):236-244. Epub 2021 May 1.

Department of Child Health and Diseases, Department of Child Neurology, Ege University School of Medicine, İzmir, Turkey.

Objective: The study aimed to evaluate the patients with a diagnosis of cerebral sinovenous thrombosis in terms of clinical findings, etiology and underlying risk factors, imaging findings, treatment, and prognosis in the long term.

Materials And Methods: Medical records of 19 patients whose ages ranged between 0 days and 17 years with clinical and radiological cerebral sinovenous thrombosis in Ege University Department of Child Neurology were retrospectively evaluated.

Results: Nine of nineteen cases were female (47. Read More

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Epidural blood patch to treat a postsurgical cerebrospinal fluid leak using central line kit.

Pain Manag 2021 Jun 9. Epub 2021 Jun 9.

Department of Anesthesiology Critical Care Medicine, Division of Pain Medicine, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.

Epidural blood patches are considered definitive treatment for postdural puncture headache in adult patients. However, they are infrequently used in children or in patients with altered spine anatomy. In patients who have undergone recent spine surgery, the lumbar epidural space can be approached safely via the caudal canal. Read More

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Arterial Ischemic Stroke-Peculiarities of Clinical Presentation and Risk Factors in Indian Children.

Neuropediatrics 2021 Jun 8. Epub 2021 Jun 8.

Division of Pediatric Neurology, Department of Pediatrics, Dayanand Medical College & Hospital, Ludhiana, Punjab, India.

There are not enough recent studies on arterial ischemic stroke (AIS) in Indian children. We retrospectively reviewed data on 95 children (69 boys), aged 3 months to 17 years, with AIS. Focal signs were noted in 84 (88%) with hemiparesis in 72 (76%). Read More

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Safety of measles, rubella and mumps vaccines in adults: a prospective cohort study.

J Travel Med 2021 Jun 9. Epub 2021 Jun 9.

The Center for Geographic Medicine and Tropical Diseases, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621, Israel.

Background: In recent years, multiple outbreaks of measles associated with vaccine hesitancy occurred in high-income countries, where measles incidence had previously been low. Most safety data about the measles, mumps and rubella (MMR) vaccine are derived from studies conducted among children, whereas evidence regarding the safety profile of the vaccine in adults is scarce.

Methods: In 2017, during an outbreak of measles in Europe, Israeli travellers to high-risk locations who were incompletely vaccinated, were urged to complete the two MMR vaccination schedule before their travel. Read More

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Efficacy and safety of bismuth-based quadruple therapy for Helicobacter pylori eradication in children.

Helicobacter 2021 Jun 7:e12825. Epub 2021 Jun 7.

Pediatric Gastroenterology, Hepatology and Obesity, HUDERF, Queen Fabiola Children's University Hospital, Université libre de Bruxelles, Brussels, Belgium.

Objectives: To evaluate the efficacy and safety of a 10-day quadruple therapy containing colloidal bismuth sub-citrate (CBS), esomeprazole (ESO), amoxicillin (AMO), and metronidazole (MET) for Helicobacter pylori (H. pylori) eradication in children.

Methods: Monocentric, open-label, prospective, single-arm clinical trial in children aged 6-17 years with H. Read More

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Postdengue chronic fatigue syndrome in an adolescent boy.

BMJ Case Rep 2021 Jun 7;14(6). Epub 2021 Jun 7.

Paediatrics, Oxford University Hospitals NHS Foundation Trust, Oxford, UK

Chronic fatigue syndrome (CFS) is often preceded by a viral illness and has recurrent 'flulike' symptoms which include a wide spectrum of musculoskeletal and neurological clinical features. The condition is also known as myalgic encephalomyelitis and systemic exertional intolerance syndrome. CFS has been reported following dengue among adult patients. Read More

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Approach to Pediatric Intractable Migraine.

Curr Neurol Neurosci Rep 2021 Jun 4;21(8):38. Epub 2021 Jun 4.

Division of Neurology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada.

Purpose Of Review: Intractable migraine in children and adolescents is a significant cause of disability and decreased quality of life (QoL) in this population. Challenges include lack of unifying definition for intractable migraine, and limited data on best-practice management in this age group, with most current treatment pathways extrapolated from adult studies or expert consensus.

Recent Findings: A comprehensive approach in the evaluation and management of intractable migraine in this age group encompasses excluding secondary causes of headache; making an accurate diagnosis; identifying and appropriately managing modifiable risk factors; and initiating appropriate pharmacologic therapy to reduce disability, improve health-related quality of life, reduce risk of progression, and develop adaptive pain coping strategies. Read More

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Post-traumatic Headache in Children and Adolescents.

Curr Pain Headache Rep 2021 Jun 4;25(8):51. Epub 2021 Jun 4.

Norton Children's Neuroscience Institute, Norton Healthcare, Louisville, KY, USA.

Purpose Of Review: Post-traumatic headache is a common disorder in the pediatric age group, seen both by child neurologists and by non-neurologists. The current review of post-traumatic headache in children and adolescents aims to review the pathophysiology, risk factors, clinical features, neuroimaging, and both acute and preventive treatment options.

Recent Findings: Recent literature provides insight into specific risk factors in the pediatric age group for developing post-traumatic headache as well as unique pathophysiologic changes seen in neuroimaging and neurometabolic pathways. Read More

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Optic nerve sheath fenestration for visual rehabilitation in moyamoya disease.

Saudi J Ophthalmol 2020 Jul-Sep;34(3):223-226. Epub 2021 Feb 27.

Department of Neuro-Ophthalmology, Sankara Nethralaya, Medical Research Foundation, Chennai, Tamil Nadu, India.

A 13-year-old female presented with decrease in vision in both eyes with headache and vomiting for 15 days. Her visual acuity was perception of light with inaccurate projection in the right eye and counting fingers close to face in the left eye. Pupils were nonreactive. Read More

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February 2021

Neurology and neuropsychiatry of COVID-19: a systematic review and meta-analysis of the early literature reveals frequent CNS manifestations and key emerging narratives.

J Neurol Neurosurg Psychiatry 2021 Jun 3. Epub 2021 Jun 3.

Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.

There is accumulating evidence of the neurological and neuropsychiatric features of infection with SARS-CoV-2. In this systematic review and meta-analysis, we aimed to describe the characteristics of the early literature and estimate point prevalences for neurological and neuropsychiatric manifestations.We searched MEDLINE, Embase, PsycINFO and CINAHL up to 18 July 2020 for randomised controlled trials, cohort studies, case-control studies, cross-sectional studies and case series. Read More

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Pseudotumor cerebri in the paediatric population: clinical features, treatment and prognosis.

Neurologia 2021 May 31. Epub 2021 May 31.

Unidad de Neurología Pediátrica. Unidad de Gestión Clínica de Pediatría y sus Especialidades. Hospital Universitario Reina Sofía, Córdoba, España; Grupo clínico vinculado al CIBERER, Área de Medicina Metabólica Hereditaria, Instituto de Salud Carlos III, Madrid, España; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, España.

Introduction: Pseudotumor cerebri (PC) in prepubertal patients displays certain characteristics that differentiate it from its presentation at the postpubertal stage. The aim of this study is to describe the characteristics of paediatric patients diagnosed with PC at our centre and to compare them according to their pubertal status.

Patients And Methods: We included patients aged between 1 and 18 years who were diagnosed with PC in a tertiary-level hospital between 2006 and 2019 and who met the updated diagnostic criteria for PC. Read More

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Long lasting insecticidal mosquito nets (LLINs) ownership, use and coverage following mass distribution campaign in Lake Victoria basin, Western Kenya.

BMC Public Health 2021 Jun 2;21(1):1046. Epub 2021 Jun 2.

International Centre of Insect Physiology and Ecology (ICIPE), PO Box 30772, Nairobi, Kenya.

Background: Long-lasting insecticidal nets (LLINs) are the most widely used malaria prevention and control intervention in Africa. However, their effectiveness may vary depending on their local geographic coverage, ownership and use at household level. This study aimed at assessing LLINs ownership and use following mass distribution campaign in western Kenya. Read More

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Analysis of early and late maternal complications associated with delivery using propensity score.

Rev Bras Epidemiol 2021 26;24:e210027. Epub 2021 May 26.

Epidemiological Research Center, Post-Graduation Program in Epidemiology, Universidade Federal de Pelotas - Pelotas (RS), Brazil.

Objective: To analyze early and late maternal complications associated with the mode of delivery in a birth cohort in Brazil, using the propensity score technique for analysis.

Methods: This is a prospective cohort study, using data from the Pelotas Birth Cohort, RS, 2004. A total of 4,189 women were included and a descriptive analysis of the data and subsequent calculation of the propensity and pairing score of vaginal delivery women and cesarean delivery women with similar scores (1,366 pairs). Read More

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The prevalence and burden of recurrent headache in Australian adolescents: findings from the longitudinal study of Australian children.

J Headache Pain 2021 Jun 1;22(1):49. Epub 2021 Jun 1.

School of Health Sciences and Social Work, Griffith University, Nathan, Brisbane, 4111, Australia.

Background: Headache disorders are highly prevalent worldwide, but not well investigated in adolescents. Few studies have included representative nationwide samples. This study aimed to present the prevalence and burden of recurrent headache in Australian adolescents. Read More

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The Differences in Clinical Presentation, Management, and Prognosis of Laboratory-Confirmed COVID-19 between Pregnant and Non-Pregnant Women: A Systematic Review and Meta-Analysis.

Int J Environ Res Public Health 2021 05 24;18(11). Epub 2021 May 24.

Robinson Research Institute, University of Adelaide, Adelaide 5005, Australia.

Background: The coronavirus disease 2019 (COVID-19) pandemic has affected millions of people across the globe. Previous coronavirus outbreaks led to worsened symptoms amongst pregnant women, suggesting that pregnant women are at greater risk.

Objectives: Our aim is to investigate the differences in clinical presentation, management, and prognosis of COVID-19 infection in pregnant and non-pregnant women. Read More

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Findings of Brain Magnetic Resonance Imaging in Girls with Central Precocious Puberty Compared with Girls with Chronic or Recurrent Headache.

J Clin Med 2021 May 19;10(10). Epub 2021 May 19.

Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

In the present study, the results of brain magnetic resonance imaging (MRI) in girls with central precocious puberty (CPP) were compared those in with girls evaluated for headaches. A total of 295 girls with CPP who underwent sellar MRI were enrolled. A total of 205 age-matched girls with chronic or recurrent headaches without neurological abnormality who had brain MRI were included as controls. Read More

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Use of Nutraceutical Ingredient Combinations in the Management of Tension-Type Headaches with or without Sleep Disorders.

Nutrients 2021 May 13;13(5). Epub 2021 May 13.

Child Neurology and Psychiatry Medicine, Systems Medicine Department, Tor Vergata University of Rome, Via Montpellier 1, 00133 Rome, Italy.

Headache is the most common pain complaint in the pediatric population, with tension type headache (TTH) having a prevalence of 10-15% in children. Up to 70% of pediatric patients with chronic headache also experience sleep disruption, with a likely bidirectional relationship between headache and poor sleep. Treatment options include specific pharmacological approaches as well as non-pharmacological alternatives; nutraceuticals have the advantage of a relative lack of side effects. Read More

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Unraveling the Etiology of Pediatric Vertigo and Dizziness: A Tertiary Pediatric Center Experience.

Medicina (Kaunas) 2021 May 11;57(5). Epub 2021 May 11.

Department of Otorhinolaryngology and Cervicofacial Surgery, University Medical Centre Ljubljana, Zaloška Cesta 2, SI-1000 Ljubljana, Slovenia.

: Numerous authors have reported that the commonest type of vertigo in children is migraine-associated vertigo (vestibular migraine and benign paroxysmal vertigo of childhood-BPV). We aimed to provide the possible etiological background of vertigo and dizziness in Slovenian children. : A retrospective case series of pediatric vertigo and dizziness children referred to the tertiary pediatric otorhinolaryngology center from 2015 to 2020. Read More

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Anthelmintics for people with neurocysticercosis.

Cochrane Database Syst Rev 2021 06 1;6:CD000215. Epub 2021 Jun 1.

Institute of Neurology, Madras Medical College, Chennai, India.

Background: Neurocysticercosis is a parasitic infection of the central nervous system by the larval stage of the pork tapeworm and is a common cause of seizures and epilepsy in endemic areas. Anthelmintics (albendazole or praziquantel) may be given alongside supportive treatment (antiepileptics/analgesia) with the aim of killing these larvae (cysticerci), with or without corticosteroid treatment. However, there are potential adverse effects of these drugs, and the cysticerci may eventually die without directed anthelminthic treatment. Read More

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Neuroophthalmic Manifestations of Intracranial Tumours in Children.

Case Rep Ophthalmol Med 2021 15;2021:7793382. Epub 2021 May 15.

Department of Neurosurgery, Dr. D.Y. Patil Medical College and Hospital, Pimpri, Pune, Maharashtra, India.

Background: All children between 0 and 16 years presenting with brain tumours confirmed by Magnetic Resonance Imaging (MRI) and treated surgically in our institute were included in this study.

Objective: The aim of this study is to evaluate the neuroophthalmic and clinical characteristics of intracranial space occupying lesions in children.

Methods: Neuroophthalmic manifestations along with location of the tumour by contrast-enhanced MRI, type of surgical intervention, and postoperative histopathological diagnosis were evaluated. Read More

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Effect of Topical Brimonidine 0.15% on Conjunctival Injection after Strabismus Surgery in Children.

J Ophthalmol 2021 4;2021:5574194. Epub 2021 May 4.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

Purpose: To investigate the effects of topical brimonidine 0.15% instillation on conjunctival injection after strabismus surgery in children.

Methods: We retrospectively analyzed 63 Korean children who underwent strabismus surgery for intermittent exotropia. Read More

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Longitudinal study of early adaptation to the coronavirus disease pandemic among youth with chronic pain and their parents: effects of direct exposures and economic stress.

Pain 2021 Apr 2. Epub 2021 Apr 2.

Center for Child Health, Behavior and Development, Seattle Children's Research Institute Seattle, WA, United States, Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine Seattle, WA, United States, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, United States.

Abstract: The novel coronavirus disease (COVID-19) has caused prolonged disruptions in daily life for many communities. Little is known about the impact of the COVID-19 pandemic on the health and well-being of youth with chronic pain and their families. We conducted a longitudinal, mixed-methods study to characterize early adaptation to the COVID-19 pandemic among 250 families of youth (ages 12-21 years) diagnosed with chronic headache (64%) or other chronic pain conditions (36%) and to determine whether direct exposures to COVID-19 and secondary economic stress modified symptom trajectories. Read More

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Headache in Children and Adolescents.

Continuum (Minneap Minn) 2021 06;27(3):703-731

Purpose Of Review: This article reviews the approach to a child or adolescent with headache, the criteria for common diagnoses, and the evidence base for treatments.

Recent Findings: The guidelines for acute and preventive treatment of migraine were updated in 2019. These guidelines summarize the available evidence and outline the questions that should be addressed in future research. Read More

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Headache in Women.

Continuum (Minneap Minn) 2021 06;27(3):686-702

Purpose Of Review: Women are greatly overrepresented among patients seeking treatment for symptoms of headache pain in general and migraine in particular. Understanding the presentation of headache in women in relation to hormonal changes both during the menstrual cycle and throughout the life span is essential for appropriate diagnosis and treatment.

Recent Findings: Although perimenstrual migraine attacks are generally without aura, the diagnosis of migraine with aura has been added to the headache classification for menstrual migraine to account for women with the diagnosis of migraine with aura who experience menstrual migraine attacks. Read More

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New Daily Persistent Headache in a Pediatric Population.

J Child Neurol 2021 May 28:8830738211004514. Epub 2021 May 28.

Children's National Hospital, Washington, DC, USA.

Introduction: New daily persistent headache (NDPH) is a primary headache disorder characterized by an intractable, daily, and unremitting headache lasting for at least 3 months. Currently, there are limited studies in the pediatric population describing the characteristics of NDPH.

Objective: The objective of the current study is to describe the characteristics of NDPH in pediatric patients presenting to a headache program at a tertiary referral center. Read More

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Fatal Acute Hemorrhagic Leukoencephalitis Following Immunization Against Human Papillomavirus in a 14-Year-Old Boy.

Child Neurol Open 2021 Jan-Dec;8:2329048X211016109. Epub 2021 May 18.

Department of Pediatrics, Atrium Health/Levine Children's Hospital, Charlotte, NC, USA.

Human papilloma virus (HPV) is a prevalent pathogen whose persistent infection can lead to a variety of cancers. To protect against this threat, an HPV vaccine has been developed and is routinely administered to adolescents. The HPV vaccine has a reassuring safety profile, but reports have emerged of acute disseminated encephalomyelitis following its administration. Read More

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