12,738 results match your criteria Headache Children


Serum Homocysteine, Pyridoxine, Folate, and Vitamin B12 Levels in Migraine: Systematic Review and Meta-Analysis.

Headache 2020 Jul 2. Epub 2020 Jul 2.

Department of Neurology, University Hospital of Larissa, School of Medicine, University of Thessaly, Larissa, Greece.

Background: Migraine, especially migraine with aura (MA), has been linked to increased risk for ischemic cerebrovascular disease. The possible role of elevated serum homocysteine (Hcy, a cause of thrombophilia) in migraine has been demonstrated by several studies.

Objective: The present study aims to review and meta-analyze data from studies investigating the difference of serum Hcy and Hcy lowering vitamins between migraine patients and healthy controls (HC), as well as between patients with MA and migraine without aura (MO). Read More

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http://dx.doi.org/10.1111/head.13892DOI Listing

Safety and Efficacy of Centanafadine Sustained-Release in Adults With Attention-Deficit Hyperactivity Disorder: Results of Phase 2 Studies.

Neuropsychiatr Dis Treat 2020 8;16:1411-1426. Epub 2020 Jun 8.

Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Purpose: Two phase 2 studies evaluated the efficacy and tolerability of centanafadine sustained-release (SR) for adults with attention-deficit/hyperactivity disorder (ADHD).

Patients And Methods: In a phase 2a, flexible-dose, single-blind study, 41 male patients (aged 18‒55 years) with a diagnosis of ADHD (based on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) were titrated with centanafadine-SR 200‒300, 400, or 500 mg/d for 2 weeks, and then were treated with the titrated dose for 2 weeks. In a phase 2b, randomized, double-blind, placebo-controlled, crossover study, 85 male and female patients (aged 18‒60 years) with a diagnosis of ADHD (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition) were titrated to target doses of centanafadine-SR 400, 500, 600, or 800 mg/d over the course of 1 week, and then received their titrated dose for 3 weeks. Read More

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http://dx.doi.org/10.2147/NDT.S242084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292254PMC

Clinical Profile and Outcome of Brain Abscess in Children from a Tertiary Care Hospital in Eastern Uttar Pradesh.

Ann Indian Acad Neurol 2020 May-Jun;23(3):303-307. Epub 2020 Jun 10.

Department of Paediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Background And Aims: Brain abscess is a serious and dreadful disease presenting at tertiary centre. The objective of this study was to look into the clinical profile, predisposing conditions, microbiology and outcome of children suffering from brain abscess.

Methods: 30 children up to 18 years with clinical and imaging evidence of brain abscess were taken for study. Read More

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http://dx.doi.org/10.4103/aian.AIAN_425_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313559PMC

Symptom Score: A New Instrument to Assess Orthostatic Intolerance in Children and Adolescents.

J Child Neurol 2020 Jun 29:883073820936025. Epub 2020 Jun 29.

Department of Pediatric Cardiovasology, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Objective: To develop an orthostatic intolerance symptom scoring system to assess orthostatic intolerance and then to compare the symptom score among different head-up tilt test responses.

Methods: 272 subjects (5-18 years) presenting with orthostatic intolerance symptoms finished questionnaire and head-up tilt test. According to head-up tilt test hemodynamic responses, the subjects were divided into head-up tilt test negative, vasovagal syncope, and postural tachycardia syndrome groups. Read More

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http://dx.doi.org/10.1177/0883073820936025DOI Listing

Cinnarizine as alternative recommendation for migraine prophylaxis: a narrative review.

Expert Rev Neurother 2020 Jun 29. Epub 2020 Jun 29.

Headache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences , Tehran, Iran.

Introduction: Despite the available prophylactic and acute drugs for migraine management, this disabling disorder remains undertreated especially among pediatrics. In this review, the authors aim at assessing the preventive role cinnarizine plays in treating migraine based on previously published studies.

Areas Covered: Randomized clinical trials, randomized controlled trials, non-randomized open-label trials and retrospective studies concerning cinnarizine in migraine prevention in children and adults were reviewed. Read More

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http://dx.doi.org/10.1080/14737175.2020.1787834DOI Listing

An open-label, multicentre, randomized comparative study of efficacy, safety and tolerability of the 5 plant - extract BNO 1012 in the Delayed Antibiotic Prescription Method in children, aged 6 to 11 years with acute viral and post-viral rhinosinusitis.

Am J Otolaryngol 2020 Jun 1;41(5):102564. Epub 2020 Jun 1.

Department of Pediatric Otolaryngology of the National Academy of the Postgraduate Education, 9, Dorogozhytska Street, Kyiv 04112, Ukraine.

Acute rhinosinusitis (ARS) can be characterized as bacterial (ABRS) and require antibiotic therapy only in 0.5-5% of cases. In most cases, the disease is in a viral and post-viral form, which requires pathogenetic and symptomatic treatment. Read More

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http://dx.doi.org/10.1016/j.amjoto.2020.102564DOI Listing

Management of spontaneous intracranial hypotension: a series of 31 cases over 15-years with a challenging outlier.

Br J Neurosurg 2020 Jun 26:1-3. Epub 2020 Jun 26.

Department of Neurosurgery, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland.

Spontaneous intracranial hypotension (SIH) has been classified as a triad of postural headache, low CSF opening pressure (below 60mmH0) and diffuse pachymeningeal gadolinium enhancement on MRI. SIH is due to a non-iatrogenic defect in the dura somewhere along the neuraxis (usually in the spine). The resultant leak depressurizes the system and undermines the buoyancy-providing quality of CSF. Read More

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http://dx.doi.org/10.1080/02688697.2020.1784845DOI Listing

Pituitary adenoma presenting as acute onset isolated complete third cranial nerve palsy without vision changes.

BMJ Case Rep 2020 Jun 24;13(6). Epub 2020 Jun 24.

Child Sight Institute, Pediatric Ophthalmology, Strabismus and Neuro-ophthalmology, Nimmagadda Prasad Children Eye Care Centre, LV Prasad Eye Institute, GMRV Campus, Visakhapatnam, Andhra Pradesh, India

We report a case of isolated unilateral complete pupil involving third cranial nerve palsy due to pituitary adenoma with parasellar extension into the right cavernous sinus. The patient was referred to us from neurosurgery with sudden onset binocular vertical diplopia with complete ptosis, and mild right-sided headache of 5-day duration. Ocular examination revealed pupil involving third cranial nerve palsy in right eye while rest of the examination including automated perimetry was normal. Read More

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http://dx.doi.org/10.1136/bcr-2019-232490DOI Listing

Multimodal Imaging of Optic Nerve Drusen in a 10-year Hyperopic Child.

J Coll Physicians Surg Pak 2020 May;30(5):541-542

Department of Ophthalmology, University of Health Sciences, Beyoglu Eye Training and Research Hospital Istanbul, Turkey.

Optic nerve drusen (OND) are abnormal calcified acellular deposits located within the prelaminar portion of the optic nerve. They are usually asymptomatic and detected incidentally during fundoscopic examination. They have a clinical significance due to their appearance which mimicks true papilledema, if the drusen are buried. Read More

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http://dx.doi.org/10.29271/jcpsp.2020.05.541DOI Listing

Impact of primary headache disorder on quality of life among school students in Kuwait.

J Headache Pain 2020 Jun 24;21(1):80. Epub 2020 Jun 24.

Neurology Department, Ibn Sina Hospital, P.O. Box 25427, Safat, 13115, Kuwait City, Kuwait.

Background: Primary headache disorders have being increasingly reported in younger populations. They can have significant effects on their quality of life and academic achievement and may cause significant distress to their families.

Aims And Objectives: To assess the burden of primary headache disorder and its impact on the quality of life on school student in Kuwait. Read More

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http://dx.doi.org/10.1186/s10194-020-01124-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313161PMC

The Efficacy of Botulinum Toxin in Pediatric Chronic Migraine: A Literature Review.

J Child Neurol 2020 Jun 24:883073820931256. Epub 2020 Jun 24.

Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Aims: To conduct a review of the literature on the use of botulinum toxin for the treatment of pediatric chronic migraine.

Methods: A review of the literature was performed using EMBASE, PubMed, and Cochrane/Ovid. Using our inclusion and exclusion criteria, we targeted any study, published before April 2020, evaluating the efficacy of botulinum toxin in migraineurs younger than 18 years. Read More

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http://dx.doi.org/10.1177/0883073820931256DOI Listing

Clinical characteristics of children and adults with anti-N-methyl-D-aspartate receptor encephalitis.

Clin Neurol Neurosurg 2020 Jun 12;196:106015. Epub 2020 Jun 12.

Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.

Objectives: To investigate the clinical characteristics of children and adults with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis.

Methods: Patients who tested positive for the anti-NMDAR antibody (by a cell-based assay) in the cerebrospinal fluid were enrolled. They were divided into two groups based on age (<16 years or older). Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.106015DOI Listing

Short-term Treatment of Migraine in Children and Adolescents.

JAMA Pediatr 2020 Jun 22. Epub 2020 Jun 22.

Pediatric Headache Center, Dell Medical School, Department of Neurology, University of Texas at Austin, Austin.

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http://dx.doi.org/10.1001/jamapediatrics.2020.1422DOI Listing

A Comparison Between Chinese Children Infected with COVID-19 and with SARS.

J Pediatr 2020 Jun 18. Epub 2020 Jun 18.

Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China. Electronic address:

Objectives: To compare the clinical and laboratory features of severe acute respiratory syndrome 2003 (SARS) and coronavirus disease 2019 (COVID-19) in two Chinese pediatric cohorts, given that the causative pathogens and are biologically similar.

, Study Design: This is a cross-sectional study reviewing paediatric patients with SARS (n = 43) and COVID-19 (n=244) who were admitted to the Princess Margaret Hospital in Hong Kong and Wuhan Children's Hospital in Wuhan, respectively. Demographics, hospital length of stay, clinical and laboratory features were compared RESULTS: Overall, 97. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.06.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301144PMC
June 2020
3.790 Impact Factor

The first case of teeth discoloration induced by linezolid in children in China Mainland.

J Infect Chemother 2020 Jun 17. Epub 2020 Jun 17.

Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China. Electronic address:

Linezolid is an oxazolidinone antimicrobial agent often used to treat multidrug-resistant Gram-positive bacterial infections. The common adverse reactions of linezolid are diarrhea, nausea, headache and bone marrow suppression, and so on. Here, we report the first case of teeth discoloration induced by linezolid linked with extrinsic discoloration in China Mainland. Read More

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http://dx.doi.org/10.1016/j.jiac.2020.05.010DOI Listing

Headache in children with Sturge-Weber syndrome - Prevalence, associations and impact.

Eur J Paediatr Neurol 2020 May 28. Epub 2020 May 28.

Neurosciences Unit, Great Ormond Street Hospital NHS Foundation Trust, UK; Neurosciences Unit, UCL Institute of Child Health, UK.

Background: Sturge-Weber syndrome (SWS) is a congenital neurovascular disorder characterised by capillary-venous malformations involving the skin, brain and eye. Patients experience headache, however little is known about its characteristics or associations. We aimed to estimate prevalence, associations and the impact of headache in children with SWS. Read More

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http://dx.doi.org/10.1016/j.ejpn.2020.05.001DOI Listing
May 2020
1.934 Impact Factor

A COVID-19 case report from asymptomatic contact: implication for contact isolation and incubation management.

Infect Dis Poverty 2020 Jun 19;9(1):70. Epub 2020 Jun 19.

Centre for Diseases Prevention and Control of Eastern Theater, Nanjing, 210002, China.

Background: As of 2 March, 2020, at least 80 151 coronavirus disease 2019 (COVID-19) cases were reported in China. Most of the patients had a history of visiting Hubei Province or contacting with people who had ever stayed in or passed by Hubei Province or were exposed to symptoms. Some patients got infected through only asymptomatic contact. Read More

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http://dx.doi.org/10.1186/s40249-020-00686-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303942PMC

Lactation Ketoacidosis: A Systematic Review of Case Reports.

Medicina (Kaunas) 2020 Jun 17;56(6). Epub 2020 Jun 17.

Division of Medicine, Royal Darwin Hospital, Darwin, NT 0800, Australia,

: Lactation ketoacidosis is a rare cause of high anion gap metabolic acidosis affecting breastfeeding mothers. We aim to review and analyze all cases of lactation ketoacidosis reported. : A systematic search of PubMed/MEDLINE and Cumulative Index to Nursing and Allied Health Literature (CINAHL), identifying relevant case reports published from 1 January 1970 to 31 December 2019. Read More

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http://dx.doi.org/10.3390/medicina56060299DOI Listing

Effect of anti-interleukin-1 treatment on quality of life in children with colchicine-resistant familial Mediterranean fever: A single-center experience.

Int J Rheum Dis 2020 Jun 18. Epub 2020 Jun 18.

Department of Pediatric Nephrology and Rheumatology, Ankara City Hospital, University of Health Sciences, Ankara, Turkey.

Aim: The aim of this study is to evaluate the clinical parameters, acute-phase reactants, side effects, genetic mutations among colchicine-resistant Familial Mediterranean fever (FMF) patients who received anti-interleukin-1 (anti-IL-1) treatment. We also evaluate the quality of life and school attendance among colchicine-resistant FMF patients, in relation to treatment with anti-IL-1.

Introduction: Familial Mediterranean fever is the most common inherited autoinflammatory disorder. Read More

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http://dx.doi.org/10.1111/1756-185X.13891DOI Listing

Safety and effectiveness of a somatropin biosimilar in children requiring growth hormone treatment: second analysis of the PATRO Children study Italian cohort.

J Endocrinol Invest 2020 Jun 15. Epub 2020 Jun 15.

Unit of Pediatric Endocrinology, S.Orsola-Malpighi Hospital, Bologna, Italy.

Purpose: To investigate the long-term safety (primary endpoint) and effectiveness (secondary endpoint) of the somatropin biosimilar Omnitrope.

Methods: PATRO Children is an ongoing, multicenter, observational, post-marketing surveillance study. Children who received Omnitrope for any indication were included. Read More

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http://dx.doi.org/10.1007/s40618-020-01331-4DOI Listing

Characteristics of Diagnosed Concussions in Children Aged 0 to 4 Years Presenting to a Large Pediatric Healthcare Network.

Pediatr Emerg Care 2020 Jun 16. Epub 2020 Jun 16.

From the Center for Injury Research and Prevention.

Objective: The aim of the study was to comprehensively describe the natural history of concussion in early childhood between 0 and 4 years.

Methods: Retrospective cohort study of 329 patients aged 0 to 4 years, with an International Classification of Diseases, Ninth Revision, concussion diagnosis in the Children's Hospital of Philadelphia healthcare network from October 1, 2013, to September 30, 2015. Clinical data were abstracted from the Children's Hospital of Philadelphia electronic health record, which captured all clinical care visits and injury characteristics. Read More

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http://dx.doi.org/10.1097/PEC.0000000000002148DOI Listing

Traumatic epidural hematomas in the pediatric population: clinical characteristics and diagnostic pitfalls.

J Pediatr Surg 2020 May 15. Epub 2020 May 15.

Division of Trauma, Emergency Surgery and Surgical Critical Care, LAC+USC Medical Center, University of Southern California, 2051 Marengo Street, IPT, C5L100, Los Angeles, CA 90033, USA.

Background/purpose: The purpose of this study was to review the initial clinical presentation of EDH, identify potential clinical markers and highlight diagnostic pitfalls.

Methods: Retrospective review of all pediatric patients admitted to a Level I Trauma Center diagnosed with blunt traumatic EDH from 2008 to 2018.

Results: A total of 699 pediatric patients were identified with blunt traumatic brain injury (TBI); 106 with EDH made up the study population. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2020.05.011DOI Listing

Children with Functional Nausea-Comorbidities outside the Gastrointestinal Tract.

J Pediatr 2020 Jun 9. Epub 2020 Jun 9.

Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Ann and Robert H. Lurie Children's Hospital, Chicago, IL; Department of Pediatrics, Northwestern Feinberg School of Medicine, Chicago, IL.

Objective: To detail common comorbidities and procedures performed to evaluate functional nausea in children.

Study Design: In total, 63 children age 7-18 years seen in a tertiary care pediatric clinic who met Rome IV criteria for functional nausea prospectively completed an Intake Questionnaire, the Pediatric and Parent-Proxy PROMIS-25 Profile v 2.0, the Pediatric and Parent-Proxy Pediatric Sleep Disturbance-Short Form 4a, and the COMPASS 31 orthostatic intolerance scale to assess comorbidities. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.04.019DOI Listing

Corpus Callosum Lipomas in Children.

Turk Neurosurg 2019 Dec 31. Epub 2019 Dec 31.

Tatvan State Hospital, Department of Neurosurgery, Bitlis.

Aim: Pericallosal lipomas (PCL) are congenital, benign, fat-containing brain malformations, which are closely related to the development of the primitive meninges and corpus callosum (CC).This study aimed to determine the clinical and radiographical aspects of six patients diagnosed with PCL.

Material And Methods: A retrospective analysis of patients who presented to the neurosurgery outpatient clinics of Selcuk Faculty of Medicine between 2009 and 2019 revealed that six patients were diagnosed with PCL. Read More

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http://dx.doi.org/10.5137/1019-5149.JTN.27692-19.6DOI Listing
December 2019

Pediatric Migraine and Academics.

Curr Pain Headache Rep 2020 Jun 11;24(8):40. Epub 2020 Jun 11.

The George Washington University School of Medicine & Health Sciences, Children's National Hospital, 111 Michigan Ave, NW, Washington, DC, 20010, USA.

Purpose Of Review: The purpose of this review is to examine the multitude of factors which may impact learning and academic performance in patients with pediatric migraine.

Recent Findings: A range of associations of varying degree were noted between pediatric migraine and conditions such as ADHD, learning disabilities, sleep disorders, and psychiatric comorbidities with regard to headache pain and school functioning. Recent literature highlights the importance of sleep in relation to headache, mood disorders, and learning in youth and the emerging role of perfectionism. Read More

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http://dx.doi.org/10.1007/s11916-020-00869-5DOI Listing

Epidemiology of herpes simplex and varicella zoster virus in cerebrospinal fluid of patients suffering from meningitis in Iran.

New Microbes New Infect 2020 Jul 30;36:100688. Epub 2020 Apr 30.

Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

From the early 18th century that "meningitis" outbreak was firstly recorded in Geneva, it is one of the alarming health problems worldwide. Different infectious risk factors may contribute to the progression of meningitis. Herpes simplex virus (HSV) and Varicella-zoster virus (VZV) are just some noticeable risk factors among many involved in the progression of this disease. Read More

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http://dx.doi.org/10.1016/j.nmni.2020.100688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276451PMC

Familial Kawasaki disease and acute glomerulonephritis: case report and review of literature.

Sudan J Paediatr 2020 ;20(1):68-72

Mohamed Alamin Hamid Hospital for Children, Omdurman, Sudan.

We report two siblings, a 6-year-old boy and his 4-year-old sister who were admitted with fever for 15 days and features of Kawasaki disease. After admission to the hospital, both patients developed red urine and headache. Blood pressure was found to be high in relation to blood pressure percentiles for both patients. Read More

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http://dx.doi.org/10.24911/SJP.106-1548975790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282432PMC
January 2020

Unilateral Neuroimaging Findings in Pediatric Craniofacial Scleroderma: Parry-Romberg Syndrome and En Coup de Sabre.

J Child Neurol 2020 Jun 12:883073820931253. Epub 2020 Jun 12.

Division of Pediatric Rheumatology, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.

Objective: Parry-Romberg syndrome (PRS) and en coup de sabre (ECDS) are subtypes of craniofacial localized scleroderma. Systematic analyses of central nervous system imaging findings and their clinical associations in children are lacking. Here, we aim to characterize neuroimaging findings and associated neurological symptoms in these conditions. Read More

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http://dx.doi.org/10.1177/0883073820931253DOI Listing

Diagnostic test accuracy of jolt accentuation for headache in acute meningitis in the emergency setting.

Cochrane Database Syst Rev 2020 Jun 11;6:CD012824. Epub 2020 Jun 11.

Hospital Care Research Unit, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Japan.

Background: Meningitis is inflammation of the meninges, the layers that protect the brain and spinal cord. Acute meningitis is an emergent disease that develops over the course of hours to several days. Delay in treatment can lead to serious outcomes. Read More

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http://dx.doi.org/10.1002/14651858.CD012824.pub2DOI Listing

Clinicoradiographic data and management of children with Chiari malformation type 1 and 1.5: an Italian case series.

Acta Neurol Belg 2020 Jun 10. Epub 2020 Jun 10.

Department of General Surgery and Medical Surgical Specialties, Section of Orthopaedics and Traumatologic Surgery, University of Catania, 95123, Catania, Italy.

Introduction: The widespread use of imaging has increased Chiari malformation (CM) diagnosis. CM shows clinical heterogeneity that makes management controversial. We aimed to evaluate the occurrence and clinical and radiographic presentation of children with CM-1 and CM-1. Read More

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http://dx.doi.org/10.1007/s13760-020-01398-zDOI Listing

Bow hunter syndrome: A rare yet important etiology of posterior circulation stroke.

J Clin Neurosci 2020 Jun 7. Epub 2020 Jun 7.

Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.

A6-year-oldgirl presented with acute-onset headache andfluctuating right-sided weakness.HerPedNIHSSwas13. Brain MRI/MRA showed acute pontine arterial ischemic stroke(AIS)and remote right cerebellar and thalamic infarcts. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.04.110DOI Listing

The prevalence of headache disorders in children and adolescents in Lithuania: a schools-based study.

J Headache Pain 2020 Jun 10;21(1):73. Epub 2020 Jun 10.

Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Edvard Griegs gate, Trondheim, Norway.

Background: While the Global Burden of Disease (GBD) study reports headache disorders as the second-highest cause of disability worldwide, the headache data in GBD come very largely from adults. This national study in Lithuania was part of a global schools-based programme within the Global Campaign against Headache contributing data from children (7-11 years) and adolescents (12-17 years).

Methods: The methods followed the generic protocol for the global study. Read More

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http://dx.doi.org/10.1186/s10194-020-01146-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288438PMC

Pre-operative headaches and obstructive hydrocephalus predict an extended length of stay following suboccipital decompression for pediatric Chiari I malformation.

Childs Nerv Syst 2020 Jun 9. Epub 2020 Jun 9.

Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520, USA.

Purpose: For young children and adolescents with Chiari malformation type I (CM-I), the determinants of extended length of hospital stay (LOS) after neurosurgical suboccipital decompression are obscure. Here, we investigate the impact of patient- and hospital-level risk factors on extended LOS following surgical decompression for CM-I in young children to adolescents.

Methods: The Kids' Inpatient Database year 2012 was queried. Read More

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http://dx.doi.org/10.1007/s00381-020-04688-2DOI Listing

ANOSMIA AND AGEUSIA: NOT AN UNCOMMON PRESENTATION OF COVID-19 INFECTION IN CHILDREN AND ADOLESCENTS.

Pediatr Infect Dis J 2020 Jun 8. Epub 2020 Jun 8.

From the Department of Paediatrics and Adolescent Medicine, Infectious Disease Centre, Princess Margaret Hospital, Hong Kong Special Administrative Region, China.

Since the emergence of a cluster of viral pneumonia cases in Wuhan, Hubei Province, People's Republic of China, at the end of December 2019, caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2), a novel coronavirus also known as "coronavirus disease 2019 (COVID-19)," as of 7 April 2020, more than 1,214,466 cases of COVID-19 have been reported in more than 200 countries and territories, resulting in more than 67,767 deaths. The disease was recognized by World Health Organization (WHO) as a pandemic on 11 March 2020. Published reports of adult patients with COVID-19 infection described symptoms including fever, cough, fatigue, sputum production, headache, dyspnoea and diarrhoea. Read More

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http://dx.doi.org/10.1097/INF.0000000000002718DOI Listing
June 2020
2.723 Impact Factor

Treatment of somatic symptom disorder in childhood: evidence-based psychotherapy interventions

Orv Hetil 2020 06;161(25):1050-1058

Általános Orvostudományi Kar, Klinikai Pszichológia Tanszék,Semmelweis Egyetem Budapest, Üllői út 78., 1083.

Introduction: About 25-30% of patients present themselves in general practice and specialized healthcare with medically unexplained somatic symptoms. The prevalence of these symptoms is the highest among the elderly, children and adolescents. Approximately 20% of patients in primary care and 47% of them in specialized clinics are children between the age of 7-12 who seem to have somatic symptom disorder (SSD). Read More

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http://dx.doi.org/10.1556/650.2020.31740DOI Listing

Mid-Aortic Syndrome: A Rare Cause of Renovascular Hypertension in Childhood Treated Percutaneously with an Unusual Vascular Access.

Curr Pediatr Rev 2020 06 9. Epub 2020 Jun 9.

Azienda Ospedaliero Universitaria Policlinico, Pediatric Hospital Giovanni XXIII, Pediatric Nephrology and dialysis Unit, Bari. Italy.

Introduction: Mid-Aortic Syndrome (MAS) is a rare vascular malformation characterized by segmental narrowing of the abdominal aorta and stenosis of its principal branches. Patients affected by MAS typically present malignant renovascular hypertension, with variable clinical symptoms like claudication, abdominal angina and headache. Moreover, they can develop complications such as hypertensive encephalopathy, congestive heart failure and vascular brain accidents. Read More

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http://dx.doi.org/10.2174/1573396316666200609170003DOI Listing

[Successful unrelated cord blood transplantation for extensive meningeal juvenile xanthogranuloma developing after treatment of Langerhans cell histiocytosis in a child].

Rinsho Ketsueki 2020 ;61(5):468-473

Department of Laboratory Medicine, Uji-Tokushukai Medical Center.

A 2-year and 4-month-old boy developed Langerhans cell histiocytosis (LCH) at the left parietal region of the skull. After treatment with chemotherapy, the patient achieved remission but experienced three relapses. After 3 years, he complained of headache, blurred vision, and lethargy. Read More

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http://dx.doi.org/10.11406/rinketsu.61.468DOI Listing
January 2020

Characteristics of Concussion in Elementary School-Aged Children: Implications for Clinical Management.

J Pediatr 2020 May 29. Epub 2020 May 29.

Center for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, PA.

Objective: To comprehensively characterize the clinical presentation and course of care for concussion among 5- to 11-year-old children, identifying preinjury and injury factors potentially influencing clinical outcomes.

Study Design: A single-institution retrospective cohort study using electronic health record data from children ages 5- to 11 years with a concussion from July 1, 2014, through June 30, 2015. Electronic health record data were abstracted for a 20% random sample of 292 patients. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.04.001DOI Listing

The fifth cranial nerve in headaches.

J Headache Pain 2020 Jun 5;21(1):65. Epub 2020 Jun 5.

Department of Clinical Experimental Research, Glostrup Research Institute, Rigshospitalet Glostrup, 2600, Glostrup, Denmark.

The fifth cranial nerve is the common denominator for many headaches and facial pain pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it connects to the brainstem and supplies various parts of the head and face with sensory innervation. In this review, we describe the neuroanatomical structures and pathways implicated in the sensation of the trigeminal system. Read More

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http://dx.doi.org/10.1186/s10194-020-01134-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275328PMC

Evaluation of Risk Factors for Cerebrospinal Leakage in Pediatric Patients With Cerebral Palsy Treated With Intrathecal Baclofen.

J Pediatr Orthop 2020 Jul;40(6):e522-e526

Department of Orthopaedic Surgery, Alfred I. duPont Hospital for Children, Wilmington, DE.

Background: Insertion of an intrathecal baclofen (ITB) pump can provide significant benefits in patients with cerebral palsy (CP). However, there are little data describing the risk of complications. Specifically, there is a lack of data describing the incidence of cerebrospinal fluid (CSF) leakage and risk factors following ITB placement. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001472DOI Listing

Post-traumatic stress disorder attributed to traumatic brain injury in children - a systematic review.

Brain Inj 2020 Jun 5:1-7. Epub 2020 Jun 5.

BIDMC Comprehensive Headache Center.

Objective: To assess the proportion of pediatric patients who develop post-traumatic stress disorder (PTSD) attributed to traumatic brain injury (TBI).

Methods: PubMed and Embase were searched from database inception until January 26, 2019. Two independent investigators screened titles, abstracts, and subsequently, full-text articles. Read More

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http://dx.doi.org/10.1080/02699052.2020.1764104DOI Listing

Active SMS-based surveillance of adverse events following immunisation with influenza and pertussis-containing vaccines in Australian pregnant women using AusVaxSafety.

Vaccine 2020 Jun 2;38(31):4892-4900. Epub 2020 Jun 2.

National Centre for Immunisation Research and Surveillance, Children's Hospital at Westmead, Westmead, New South Wales, Australia; Discipline of Child and Adolescent Health, University of Sydney, Sydney, Australia; Department of Microbiology and Infectious Disease, Children's Hospital at Westmead, Westmead, New South Wales, Australia. Electronic address:

Background: Maternal immunisation is important to protect both mother and baby, but safety concerns can lead to low uptake. AusVaxSafety participant-based surveillance actively monitors adverse events following immunisation (AEFI) in Australia. We aimed to analyse AEFI in the days following vaccination with seasonal inactivated influenza vaccine (IIV) and/or reduced antigen diphtheria-tetanus-acellular pertussis vaccine (dTpa) in pregnant women in Australia. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.04.056DOI Listing

Quantitative Sensory Testing in Adolescents with Co-occurring Chronic Pain and Obesity: A Pilot Study.

Children (Basel) 2020 Jun 2;7(6). Epub 2020 Jun 2.

Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Factors such as gender, ethnicity, and age affect pain processing in children and adolescents with chronic pain. Although obesity has been shown to affect pain processing in adults, almost nothing is known about pediatric populations. The aim of this pilot study was to explore whether obesity alters sensory processing in adolescents with chronic pain. Read More

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http://dx.doi.org/10.3390/children7060055DOI Listing

Comparison of the Prevalence of Infantile Colic Between Pediatric Migraine and Other Types of Pediatric Headache.

J Child Neurol 2020 Jun 3:883073820924264. Epub 2020 Jun 3.

Pediatric Headache Clinic, Day Hospitalization Department, Schneider Children's Medical Center of Israel, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background/objective: The International Headache Society lists infantile colic under "episodic syndromes that may be associated with migraine" in the ICHD3-beta version of its classification of headache disorders. The aim of this study was to examine whether this association is specific to migraine or applies to all pediatric headache types.

Methods: A cross-sectional historical study was conducted including 219 patients aged 3-18 years who presented to a tertiary pediatric headache clinic in 2016-2017. Read More

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http://dx.doi.org/10.1177/0883073820924264DOI Listing

Acute disseminated encephalomyelitis after SARS-CoV-2 infection.

Neurol Neuroimmunol Neuroinflamm 2020 09 1;7(5). Epub 2020 Jun 1.

From the Department of Neuroscience (G.N., E.P., D.F.), Ospedale Policlinico San Martino, IRCCS; Ospedale Policlinico San Martino (T.R., L.R., M.I.), IRCCS; Department of Neuroradiology (L.S., C.R.), Ospedale Policlinico San Martino, IRCCS, Genova, Italy; Department of Health Sciences (DISSAL) (L.R.), University of Genova; and Department of Neuroscience (M.I.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research (CEBR), University of Genova, Italy.

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http://dx.doi.org/10.1212/NXI.0000000000000797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286650PMC
September 2020

Clinical Features and Burden Scores in Japanese Pediatric Migraines With Brainstem Aura, Hemiplegic Migraine, and Retinal Migraine.

J Child Neurol 2020 Jun 1:883073820927840. Epub 2020 Jun 1.

Department of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo, Japan.

Background: Migraines are a broad spectrum of disorders classified by the type of aura with some requiring attentive treatment. Vasoconstrictors, including triptans, should be avoided in the acute phase of migraines with brainstem aura, in hemiplegic migraine, and in retinal migraine. This study investigated the characteristics and burden of these migraines. Read More

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http://dx.doi.org/10.1177/0883073820927840DOI Listing

The Relationship Between Parental Care and Pain in Children With Headache: A Narrative Review.

Headache 2020 Jun;60(6):1217-1224

Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy.

Purpose: In migraine or primary headache in children, parents play a fundamental role in pain management. For this narrative review, PubMed, Google Scholar, and Psych Info were searched using the terms "parent headache", "mother/father headache", "parental impact headache", "alexithymia parents headache", "catastrophizing parent headache", "family headache", "children parent headache", and "quality of life family headache". Articles were chosen for inclusion based on their relevance in to the topic. Read More

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http://dx.doi.org/10.1111/head.13822DOI Listing

Bruxism Throughout the Lifespan and Variants in , and .

J Pers Med 2020 May 27;10(2). Epub 2020 May 27.

Department of Oral Biology, University of Pittsburgh School of Dental Medicine, 412 Salk Pavilion, 335 Sutherland Drive, Pittsburgh, PA 15261, USA.

Bruxism is a masticatory muscle activity characterized by grinding of the teeth and clenching of the jaw that causes tooth wear and breakage, temporomandibular joint disorders, muscle pain, and headache. Bruxism occurs in both adults and children. Clinical characteristics and habits were evaluated in an adult sample. Read More

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http://dx.doi.org/10.3390/jpm10020044DOI Listing