82,118 results match your criteria Headache: The Journal of Head and Face Pain[Journal]
Obes Facts 2018 Dec 11;11(6):501-513. Epub 2018 Dec 11.
Department of Food and Resource Economics, University of Copenhagen, Copenhagen, Denmark.
Objectives: The study investigated whether treatment options for episodic tension-type headache vary among general practitioners (GPs) in Denmark depending on the patients' weight status and gender, and whether these decisions can be explained by the GPs' own anti-fat bias and lifestyle.
Methods: A cross-sectional questionnaire study with responses from 240 GPs on measures of anti-fat bias, healthiness of GPs' lifestyles, and reported patient treatment decisions.
Results: GPs tended to exhibit negative explicit and implicit anti-fat bias. Read More
Clin Neurol Neurosurg 2018 Dec 3;176:73-77. Epub 2018 Dec 3.
Science & Innovation Manager, R&D Department, Cumbria Partnership NHS Foundation Trust, Carlisle, CA1 3SX, UK. Electronic address:
Objective: Greater occipital nerve (GON) block is a treatment option applied for a variety of primary headache disorders. Although a patient's body position is known to have an impact on the effect of local anaesthetics, this has not before been investigated for patients undergoing GON block. Therefore, the clinical effectiveness of either a sitting or supine position was assessed. Read More
Clin Pharmacol Drug Dev 2018 Dec 10. Epub 2018 Dec 10.
GlaxoSmithKline, Clinical Pharmacology Modeling & Simulation, Collegeville, PA, USA.
This was a first-time-in-human randomized, double-blind, single-center, placebo-controlled dose-escalation study to determine the safety, tolerability, and pharmacokinetic (PK) profiles of GSK3342830 after single and repeat intravenous doses in healthy adult subjects (NCT0271424). Sixty-two subjects were enrolled: 48 subjects in part 1 (single dose) and 14 subjects in part 2 (multiple doses). Following single intravenous infusions, total systemic exposure of GSK3342830 was dose proportional over the 250- to 6000-mg dose range evaluated, whereas peak exposure was approximately dose proportional over the dose range. Read More
J Intern Med 2018 Dec 8. Epub 2018 Dec 8.
Clinical Genetics, Karolinska University Hospital, 171 76, Stockholm.
Pheochromocytomas (PCC) and paragangliomas (PGL), collectively abbreviated PPGL are rare tumours originating from the chromaffin cells in the adrenal medulla (PCC) or the sympathetic or parasympathetic extra-adrenal paraganglia (PGL) (1, 2), Figure 1. The enlarged cell volume leads to increased levels of catecholamines (adrenaline, noraderenaline and/or dopamine) and their metabolites which can be measured in plasma or urine for biochemical diagnosis. Hormone-producing PPGL commonly originate from sympathetic paraganglia in the adrenal glands, abdomen or pelvis (3). Read More
Headache 2018 Dec 10. Epub 2018 Dec 10.
Objective: To provide healthcare professionals with updated guidance in the use of novel preventive and acute treatments for migraine in adults.
Background: The principles of preventive and acute pharmacotherapy for patients with migraine have been outlined previously, but the emergence of new technologies and treatments, as well as new formulations of previously established treatments, has created a need for an updated guidance on the preventive and acute treatment of migraine.
Methods: This statement is based on a review of existing guidelines and principles for preventive and acute treatment of migraine, as well as the results of recent clinical trials of drugs and devices for these indications. Read More
Laryngorhinootologie 2018 Dec 10;97(12):875-896. Epub 2018 Dec 10.
Vestibular schwannomas are benign neoplasms originating from the Schwann cells of the vestibular vestibular nerve of the vestibulocochlear nerve, and rarely from the pars cochlearis. These are tumors that are in contact with the nerve but do not bind the fibers. Benign neoplasms of the Schwann cells of the auditory and equilibrium nerves can also occur primarily in the inner ear and are referred to as intralabyrinthine schwannomas (ILS). Read More
Neurosurg Rev 2018 Dec 10. Epub 2018 Dec 10.
Department of Neurosurgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
The aim of this study is to investigate the clinical presentation and outcomes associated with endoscopic endonasal resection of Rathke cleft cysts (RCCs). The authors retrospectively studied a series of 13 patients who were diagnosed with RCCs after endoscopic endonasal resection at the Second Xiangya Hospital between June 2016 and December 2017. All 13 patients (8 women) underwent a purely endoscopic endonasal approach (EEA) for fenestration and aspiration of RCCs with excision of the cystic wall. Read More
Neurol Sci 2018 Dec 10. Epub 2018 Dec 10.
Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China.
Objective: To investigate the clinical and imaging features of gray matter heterotopia (GMH) and improve the clinicians' understanding of the disease.
Methods: A retrospective study was performed on 15 patients with GMH diagnosed at The Affiliated Hospital of Xuzhou Medical University from November 2014 to November 2016. Their clinical and imaging features are also summarized. Read More
Neurosurgery 2018 Dec 10. Epub 2018 Dec 10.
School of Medicine, Tzu Chi University, Hualien, Taiwan, Republic of China.
Background: Management of chronic cluster headache (CCH) remains a challenging endeavor, and the optimal surgical approach for medically refractory CCH remains controversial.
Objective: To conduct a preliminary evaluation of the efficacy and safety of vidian neurectomy (VN) in patients with medically refractory CCH.
Methods: Between March 2013 and December 2015, 9 CCH patients, all of whom had failed to respond to conservative therapy, underwent VN with a precise nerve cut and maximal preservation of the sphenopalatine ganglion. Read More
Pain Med 2018 Dec 7. Epub 2018 Dec 7.
Neurology Department, University Clinical Hospital Lozano Blesa, Instituto Aragonés de Ciencias de la Salud, Grupo de Estudio de Trastornos del Movimiento y Cefaleas (GIIS070), Zaragoza, Spain; Neurology Department, University Clinical Hospital Lozano Blesa, Zaragoza, Spain.
Background. : Cluster headache is one of the most disabling of all headache conditions. Although some studies have investigated the psychological profile of patients with cluster headache, research on its impact on cognitive function in patients with episodic cluster headache outside the cluster bout is scant. Read More
J Neurol Surg Rep 2018 Oct 7;79(4):e93-e97. Epub 2018 Dec 7.
Department of Neurosurgery, Kantonsspital Aarau (KSA), Aarau, Switzerland.
Microsurgical clip ligation is considered a definitive treatment for intracranial aneurysms (IAs), resulting in low rates of local recurrence that range from 0.2 to 0.5% and a latency period that averages about a decade. Read More
Int J Health Sci (Qassim) 2018 Nov-Dec;12(6):65-68
Department of Paediatric, Paediatric Rheumatology Division, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
Mixed connective tissue disease (MCTD) or overlap syndrome is a rare disease. It has overlapping features of more than one autoimmune disease with high titer of anti-ribonucleoprotein antibodies against U1. We present a 12-year-old Saudi male patient who was presented to the dental clinic complaining from non-healing oral ulcers and multiple periapical abscesses that not responsive to extractions and the use of oral antibiotics, these symptoms were accompanied with persistent fever, headache, muscle weakness, general malaise, and painful bilateral cervical lymphadenopathy. Read More
Surg Neurol Int 2018 5;9:227. Epub 2018 Nov 5.
Department of Neurosurgery, Iran University of Medical Sciences, Tehran, Iran.
Background: Gliosarcoma (GS) is a primary rare malignant brain tumor that accounts 4% of all high-grade glial tumor of the brain.
Case Description: We present a 45-year-old female admitted to our center with progressive headache since 1 month ago concomitant with nausea and emesis and generalized weakness. Imaging revealed a large solid mass with well-defined margin and some cystic portions that enhanced brightly with contrast. Read More
Surg Neurol Int 2018 2;9:226. Epub 2018 Nov 2.
Department of Neurosurgery, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime 791-0295, Japan.
Background: Chordoid glioma of the third ventricle is a rare neuroepithelial tumor characterized by a unique histomorphology within the third ventricular region, but with radiological and histopathological features mimicking benign lesions such as meningioma. We report a case of chordoid glioma of the third ventricle and suggest a useful indicator for accurate diagnosis.
Case Description: A previously healthy 46-year-old woman was admitted to our hospital with mild headache. Read More
PLoS One 2018 11;13(12):e0208810. Epub 2018 Dec 11.
Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou, China.
Background: Dengue is one of the most important vector-bore infectious diseases in China because of its drastic increase in incidence, geographic extension and profound influence on China's economy. This study aims to retrospectively uncover the epidemiological profile of dengue in Zhejiang, one of the most developed provinces in China, and to find the problem existing in dengue control and prevention.
Methodology: Descriptive analyses on the dengue incidence and associated factors were performed. Read More
PLoS One 2018 11;13(12):e0208912. Epub 2018 Dec 11.
Centre for Social Science and Global Health, University of Amsterdam, Amsterdam, The Netherlands.
Background: In the Greater Mekong Sub-region (GMS), malaria elimination efforts are targeting the asymptomatic parasite reservoirs. Understanding community perceptions about asymptomatic malaria infections and interventions that target this reservoir is critical to the design of community engagement. This article examines knowledge, attitudes, perceptions and practices related to asymptomatic malaria infections and mass drug administration (MDA) in malaria-endemic villages in southern Savannakhet Province, Laos. Read More
Front Psychiatry 2018 23;9:626. Epub 2018 Nov 23.
Section of Psychiatry, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
"Medically Unexplained Physical Symptoms" (MUPS) defines a subgroup of patients presenting physical symptoms of unclear origin. The study aims to profile clinical and socio-demographic characteristics of patients with MUPS. This 9-years observational retrospective study assesses all patients admitted between 2008 and 2016 in the divisions of neurology and gastroenterology. Read More
J Indian Prosthodont Soc 2018 Oct;18(Suppl 1):S46-S47
Department of Prosthodontics Faculty of Dentistry, Universitas Sumatera Utara, Medan 20155, Indonesia.
Indian J Anaesth 2018 Nov;62(11):881-886
Department of Anaesthesia, Critical Care and Pain, Tata Memorial Hospital and Homi Bhabha National Institute, Mumbai, Maharashtra, India.
Background And Aims: Post-dural puncture headache (PDPH) is one of the complications following spinal anaesthesia (SA) and accidental dural puncture (ADP). In our institute, we routinely practice epidural analgesia (EA) for supra-major surgeries. Our previous audit on EA revealed 4% incidence of ADP. Read More
Minerva Endocrinol 2018 Dec 7. Epub 2018 Dec 7.
Pathology Department, Hospital General Universitario de Alicante, Alicante, Spain.
Silent somatotroph pituitary neuroendocrine tumors (or silent growth hormone pituitary neuroendocrine tumors, SGH-PitNET) are neoplasias with positive immunostaining for growth hormone (GH), in patients with no signs and symptoms of acromegaly nor biochemical evidence of GH hypersecretion. From a clinical stand-point they are considered and managed as non-functioning pituitary tumors, since they usually come to evidence due to mass-effects (headache, visual impairment, hypopituitarism) or as asymptomatic pituitary incidentalomas. SGH-PitNET have deserved little attention in the medical literature, and no specific guidelines exist regarding their management. Read More
Curr Opin Neurol 2018 Dec 10. Epub 2018 Dec 10.
Center for Stroke Research Berlin (CSB).
Purpose Of Review: Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiological syndrome characterized by acute cerebral endotheliopathy with consecutive disruption of the blood-brain barrier and vasogenic edema. Since its first description in 1996, PRES is increasingly recognized. However, many aspects of this syndrome with its wide spectrum of clinical and radiological features are still incompletely understood. Read More
J Clin Psychopharmacol 2018 Dec 6. Epub 2018 Dec 6.
Pfizer Inc, Cambridge, UK.
Background: Generalized anxiety disorder (GAD) is a common psychiatric disorder, but many patients experience only partial relief of symptoms with existing therapies. Benzodiazepines are effective in many cases but are limited by a number of significant adverse effects. PF-06372865 is a subtype-selective gamma-aminobutyric acid A (GABAA)-positive allosteric modulator lacking in functional activity at alpha 1-containing receptors that are believed to mediate many of these adverse effects. Read More
Surg Laparosc Endosc Percutan Tech 2018 Dec 10. Epub 2018 Dec 10.
Department of General Surgery, Kaizhou People Hospital, Chongqing, China.
Introduction: The efficacy of melatonin to improve sleep quality after laparoscopic cholecystectomy remains controversial. We conduct a systematic review and meta-analysis to explore the influence of melatonin intervention versus placebo on sleep quality after laparoscopic cholecystectomy.
Methods: We searched PubMed, EMbase, Web of Science, EBSCO, and Cochrane library databases through July 2018 for randomized controlled trials assessing the effect of melatonin intervention versus placebo on sleep quality after laparoscopic cholecystectomy. Read More
Int Clin Psychopharmacol 2018 Dec 5. Epub 2018 Dec 5.
Gedeon Richter Plc, Budapest, Hungary.
Lack of treatment response is a critical problem in major depressive disorder (MDD). Cariprazine is a D3-preferring dopamine D3/D2 receptor partial agonist and 5-HT1A partial agonist. This phase 3, multicenter, open-label, long-term (26-week), flexible-dose (1. Read More
Neural Regen Res 2019 Feb;14(2):313-318
Department of Neurology and Neurosurgery, School of Medicine, Collegium Medicum - University of Warmia and Mazury in Olsztyn; University Clinical Hospital in Olsztyn, Olsztyn, Poland.
Animal experiments have confirmed that mesenchymal stem cells can inhibit motor neuron apoptosis and inflammatory factor expression and increase neurotrophic factor expression. Therefore, mesenchymal stem cells have been shown to exhibit prospects in the treatment of amyotrophic lateral sclerosis. However, the safety of their clinical application needs to be validated. Read More
CMAJ 2018 Dec;190(49):E1434-E1440
Faculty of Health (Latimer), Dalhousie University; Centre for Pediatric Pain Research (Latimer, MacLeod, Sylliboy, Filiaggi, Finley), IWK Health Centre, Halifax, NS; Department of Integrated Studies (Sylliboy), McGill University, Montréal, Que.; Eskasoni Health Centre (Rudderham), Eskasoni, NS; Departments of Surgery (Lethbridge) and Anesthesia, Pain Management and Perioperative Medicine (Finley), and School of Physiotherapy (Harman), Dalhousie University, Halifax, NS.
Background: Indigenous youth have higher rates of chronic health conditions interfering with healthy development, including high rates of ear, dental, chest and musculoskeletal pain, as well as headache, arthritis and mental health issues. This study explores differences in pain-related diagnoses in First Nations and non-First Nations children.
Methods: Data from a study population of age- and sex-matched First Nations and non-First Nations children and youth were accessed from a specific region of Atlantic Canada. Read More
Int Immunopharmacol 2018 Dec 6;67:13-21. Epub 2018 Dec 6.
Provincial Key Lab. of the Conservation and Exploitation Research of Biological Resources in Anhui, Life Science College of Anhui Normal University, Wuhu, Anhui 241000, China. Electronic address:
Helicid (4-formylphenyl-β-D-allopyranoside) is a bioactive constituent of Helicid nilgirica Bedd that has been used in Chinese traditional herbal medicine to treat headache, insomnia, and depression. However, the underlying mechanisms of these effects are unclear. We have now investigated the effect of helicid on depression-related behaviors in rats exposed to chronic unpredictable mild stress (CUMS) and have also explored possible underlying mechanisms that involve neurotrophin expression. Read More
World Neurosurg 2018 Dec 6. Epub 2018 Dec 6.
Department of Neurosurgery, Tokyo Medical University, #6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
The combined transpetrosal approach enables wide exposure around the petroclival region by lifting of the middle fossa dura and cutting of the tentorium. However, interruption of the venous drainage on the middle skull base during the transpetrosal approach has been reported to lead to temporal lobe damage.(1,2) This video (Video 1) demonstrates a microsurgical technique for the preservation of various venous drainage in the middle fossa, including the sphenobasal and sphenopetrosal veins, during the combined transpetrosal approach for treatment of a petroclival meningioma. Read More
Semergen 2018 Dec 7. Epub 2018 Dec 7.
Centro de Salud Universitario La Paz, Servicio Extremeño de Salud, Badajoz, España. Electronic address:
Introduction: In assessing the patient with headache, clinicians are often faced with 2 important questions: Is this headache a migraine? Does this patient require neuroimaging? The aim of this study was to assess the validity and applicability of the mnemonic POUNDing rule in patients diagnosed with migraine.
Patients And Methods: A descriptive, validation study of the POUNDing rule in patients with a diagnosis of migraines and with a brain imaging test (computed tomography or magnetic resonance imaging), in an urban health centre and a neurology clinic of the University Hospital of Badajoz.
Results: A total of 116 patients were included (mean age 45. Read More
J Invest Dermatol 2018 Dec 5. Epub 2018 Dec 5.
Icahn School of Medicine at the Mount Sinai Medical Center, New York, NY, USA.
Background: and Purpose: A phase 2, double-blind, placebo-controlled trial evaluated apremilast efficacy, safety, and pharmacodynamics in adults with moderate to severe atopic dermatitis (AD).
Study Design: and Methods: Patients were randomized to placebo, apremilast 30 mg BID (APR30), or apremilast 40 mg BID (APR40) for 12 weeks. During Weeks 12-24, all patients received APR30 or APR40. Read More
J Vasc Surg 2018 Oct 24. Epub 2018 Oct 24.
Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minn.
Objective: The objective of this study was to evaluate outcomes of endovascular treatment of aortic coarctation in adults.
Methods: Clinical data and imaging studies of 93 consecutive patients treated at nine institutions from 1999 to 2015 were reviewed. We included newly diagnosed aortic coarctation (NCO), recurrent coarctation, and aneurysmal/pseudoaneurysmal degeneration (ANE) after prior open surgical repair (OSR) of coarctation. Read More
J Clin Neurosci 2018 Oct 24. Epub 2018 Oct 24.
Pathology, SGPGIMS, India.
Cortical ependymomas (CE) are rare subset of supratentorial ependymoma which are located in the peripheral cortical rim without any connection to the ventricular lining. With limited cases previously reported, current knowledge on diagnosis and management of tumors is lacking. We present the largest single center experience on CE reported so far and highlight their clinico-radiological aspects, histopathological features as well the results of their surgical excision. Read More
J Plast Reconstr Aesthet Surg 2018 Nov 22. Epub 2018 Nov 22.
Department of Oral and Maxillofacial Surgery, University of Groningen and University Medical Center Groningen (UMCG), PO BOX 30.001, Groningen 9700 RB, The Netherlands.
Objective: Various functional outcomes after upper blepharoplasty are reported in the literature. We systematically reviewed the literature to assess the objective and subjective functional effects of upper blepharoplasty.
Methods: After a systematic search of four search engines (Pubmed, Embase, Cinahl and Cochraine), any study on objective and subjective (patient reported) functional outcome after upper blepharoplasty was subjected to a quality assessment for possible inclusion in the review. Read More
Eur Ann Otorhinolaryngol Head Neck Dis 2018 Dec 4. Epub 2018 Dec 4.
Département d'otorhinolaryngologie/chirurgie cervico-faciale/chirurgie de la base du crâne, université Paris-Diderot, hôpital Lariboisière, AP-HP, Paris, France.
Introduction: Chronic invasive fungal rhinosinusitis (CIFR) is a rare entity generally observed in immunodepressed subjects. The pathogen most frequently identified is Aspergillus spp. Imaging generally reveals invasive pseudoneoplastic features. Read More
J Emerg Med 2018 Dec 4. Epub 2018 Dec 4.
Division of Global Health and Human Rights, Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts; African Institute for Health Transformation at Sagam Community Hospital, Luanda, Kenya; Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.
Background: Emergency care is a neglected area of focus in many low- and middle-income countries. There is a paucity of research on types and frequencies of acute illnesses and injuries in low-resource settings.
Objective: The primary objective of this study was to describe the demographic characteristics and emergency conditions of patients that presented to a new emergency care center (ECC) at Sagam Community Hospital in Luanda, Kenya. Read More
J Sex Med 2018 Dec;15(12):1663-1666
Sexual & Reproductive Medicine Program, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:
Am J Trop Med Hyg 2018 Dec 10. Epub 2018 Dec 10.
Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
From April to September 2017, Bangladesh experienced a huge outbreak of acute Chikungunya virus infection in Dhaka. This series describes the clinical and laboratory features of a large number of cases (690; 399 confirmed and 291 probable) suffered during that period. This observational study was carried out at Dhaka Medical College Hospital, Bangladesh. Read More
Expert Opin Pharmacother 2018 Dec 7:1-9. Epub 2018 Dec 7.
a Headache and Pain Unit, Department of Neurological , Motor and Sensorial Sciences; IRCCS San Raffaele Pisana , Rome , Italy.
Introduction: Migraine is increasingly recognized as an extremely burdensome and disabling disorder in both children and adolescents. A proper treatment plan is needed to improve the quality of life of both children and families as well as to minimize the risk of disease progression. Areas covered: This review focuses on the current pharmacotherapy for acute migraine in pediatric populations, taking into account specific considerations for those drugs tested in randomized, placebo-controlled trials (RCTs). Read More
Cephalalgia 2018 Dec 10:333102418795163. Epub 2018 Dec 10.
1 Department of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland.
Background: Several previous studies have investigated cortical abnormalities, specifically cortical thickness, in patients with migraine, with variable results. The relatively small sample sizes of most previous studies may partially explain these inconsistencies.
Objective: To investigate differences of cortical thickness between control subjects and migraineurs in a large cohort. Read More
Ann Otol Rhinol Laryngol 2018 Dec 10:3489418816999. Epub 2018 Dec 10.
1 Department of Otolaryngology/Head & Neck Surgery, Thomas Jefferson University Hospitals, Philadelphia, PA, USA.
Objectives:: (1) To define patient demographics and common symptoms in patients who undergo styloidectomy for stylohyoid pain syndrome (Eagle's syndrome). (2) To evaluate the effectiveness of styloidectomy in reducing symptoms of Eagle's syndrome.
Methods:: Retrospective chart review and prospective case series. Read More
Semin Neurol 2018 Dec 6;38(6):627-633. Epub 2018 Dec 6.
Department of Neurology, University at Buffalo School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, New York.
Headache is a neurologic disorder that displays gender dichotomy. It is well established that there is a strong link between migraine headache and sex hormones, specifically estrogen, which influences the severity of migraines during the menstrual cycle, pregnancy, and menopause. Furthermore, the epidemiology of headaches during pregnancy and the postpartum period is very distinct from that in males or nonpregnant females, in part due to the hemodynamic and hematologic changes that occur during pregnancy. Read More
Semin Neurol 2018 Dec 6;38(6):619-626. Epub 2018 Dec 6.
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.
Posttraumatic headaches are among the most challenging complaints after mild traumatic brain injury (mTBI). They are a debilitating problem experienced by patients after TBI of all severities. Up to 90% of mild TBI patients experience headache, particularly if female and with a premorbid history of primary headache. Read More
Semin Neurol 2018 Dec 6;38(6):608-618. Epub 2018 Dec 6.
Department of Neurology, Boston Medical Center, Boston, Massachusetts.
Migraine and tension-type headache (TTH) are common primary disorders that carry significant morbidity and socioeconomic effect. In this article, we will review the epidemiology, presentation, and diagnosis of these disorders. First-line acute treatment for migraine consists of analgesics, triptans, and antiemetics, while nonsteroidal anti-inflammatory drugs are the mainstay treatment for TTH. Read More
Semin Neurol 2018 Dec 6;38(6):603-607. Epub 2018 Dec 6.
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.
The trigeminal autonomic cephalalgias are a group of distinct primary headache disorders that share common characteristics of strict unilateral headache often accompanied by unilateral cranial autonomic features. Cluster headache is the most well-known example, but other than neurologists, practitioners often have limited familiarity with these disorders and treatment options. Delays in diagnosis are typical and treatment options remain suboptimal, associated with limited scientific research into these brain disorders. Read More
Semin Neurol 2018 Dec 6;38(6):601-602. Epub 2018 Dec 6.
Department of Neurology, Boston University Medical Center, Boston, Massachusetts.
Am J Respir Crit Care Med 2018 Dec 6. Epub 2018 Dec 6.
Case Western Reserve University, Cleveland, Ohio, United States.
Rationale: Primary treatment of obstructive sleep apnea can be accompanied by a persistence of excessive sleepiness despite adherence. Furthermore, effectiveness of sleep apnea treatment is limited by poor adherence. Currently available pharmacologic options for the treatment of sleepiness in this population are limited. Read More
PLoS One 2018 6;13(12):e0208435. Epub 2018 Dec 6.
Occupational and environmental medicine, Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Recurrent headache, abdominal and musculoskeletal pain are common in adolescents and it is therefore important to understand their impact on the transitional period from childhood to adulthood. However, studies of the prevalence over time and implications on educational outcomes are still limited, especially regarding multiple pain symptoms. The present study material consists of questionnaire surveys, completed in 2000 and 2008, including two study populations of 9th grade adolescents aged 15 living in West Sweden (n = 20 877). Read More