652,090 results match your criteria Head and Neck Carcinoma in the Young Patient


Evaluation of Blunt Force Trauma for Culling of Neonatal Piglets On-Farm.

J Anim Sci 2020 Jul 3. Epub 2020 Jul 3.

Embrapa Suínos e Aves, Concórdia, Brazil.

Twenty-seven neonate piglets (range from 0.35 to 1.17 kg) were evaluated for the effectiveness of blunt force trauma as a method of on-farm cull. Read More

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http://dx.doi.org/10.1093/jas/skaa204DOI Listing

Transoral thyroidectomy (TOETVA): Complications, surgical time and learning curve.

Oral Oncol 2020 Jun 30;110:104871. Epub 2020 Jun 30.

Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, Sao Paulo, Brazil; Head and Neck Surgery, University of São Paulo Medical School, Sao Paulo, Brazil.

Background: Since 2018, transoral endoscopic thyroidectomy vestibular approach (TOETVA) has emerged as a true scarless thyroid surgery. In this study, we explore early outcomes and learning curve of this new approach.

Methods: A retrospective cohort including conventional thyroidectomies and TOETVAs performed in a cancer center was designed. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104871DOI Listing

Radiomic analysis identifies tumor subtypes associated with distinct molecular and microenvironmental factors in head and neck squamous cell carcinoma.

Oral Oncol 2020 Jun 30;110:104877. Epub 2020 Jun 30.

Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

Purpose: To identify whether radiomic features from pre-treatment computed tomography (CT) scans can predict molecular differences between head and neck squamous cell carcinoma (HNSCC) using The Cancer Imaging Archive (TCIA) and The Cancer Genome Atlas (TCGA).

Methods: 77 patients from the TCIA with HNSCC had imaging suitable for analysis. Radiomic features were extracted and unsupervised consensus clustering was performed to identify subtypes. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104877DOI Listing

Surgical outcomes in traumatic brain injuries with bilateral mass occupying lesions. Analysis of prognostic factors.

Clin Neurol Neurosurg 2020 Jun 20;196:106017. Epub 2020 Jun 20.

Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka 560029, India. Electronic address:

Introduction: Traumatic brain injury is a silent epidemic with major impacts on national productivity as it affects the economically productive age group. Bilateral injuries are usually severe with no clearly defined predictors of outcome as per current available literature.

Methods: We retrospectively assessed 102 consecutive cases of post traumatic intracranial mass lesions operated bilaterally, either simultaneously or sequentially, between January 2011 and April 2019. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.106017DOI Listing

Rituximab as an effective therapeutic option in refractory Neuro-Behçet syndrome.

J Neuroimmunol 2020 Jun 26;346:577308. Epub 2020 Jun 26.

Multiple sclerosis and Demyelinating disorders Clinic, National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Head of Neurology Department National Institute of Neurology and Neurosurgery, Mexico City, Mexico.

Introduction: Behçet's disease (BD) is an inflammatory disease of unknown etiology with periods of relapses and remissions. Neuro-Behçet syndrome (NBS) is one of the main causes of long-term morbidity and mortality, making its prompt recognition and early treatment fundamental to achieving a better outcome. Currently there are no treatment guidelines either for BS or NB, making the management of these patients particularly difficult. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2020.577308DOI Listing

Characterizing Early Inpatient Death After Trauma.

J Surg Res 2020 Jun 30;255:405-410. Epub 2020 Jun 30.

Division of Trauma, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address:

Background: There is a paucity of data to predict early death or futility after trauma. The objective of this study was to characterize the laboratory values, blood product administration, and hospital disposition for patients with trauma who died within 72 h of admission.

Methods: All deaths within 72 h of admission over a 5-y period at a level I trauma center were reviewed. Read More

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http://dx.doi.org/10.1016/j.jss.2020.05.083DOI Listing

Peripheral cytokines are not influenced by the type of surgical approach for non-small cell lung cancer by four weeks postoperatively.

Lung Cancer 2020 Jun 27;146:303-309. Epub 2020 Jun 27.

Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, United States. Electronic address:

Objectives: The influence of surgical approach on systemic inflammatory response and the subsequent oncologic impact for non-small cell lung cancer is debated. We aimed to measure the effects of thoracic surgical approach on peripheral cytokine milieu over time.

Methods: Patients undergoing primary lung resection without neoadjuvant therapy (2016-2018) were evaluated. Read More

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http://dx.doi.org/10.1016/j.lungcan.2020.06.022DOI Listing

Molecular characteristics of extended-spectrum β-lactamase-producing Klebsiella pneumoniae in Japan: predominance of CTX-M-15 and emergence of hypervirulent clones.

Int J Infect Dis 2020 Jun 30. Epub 2020 Jun 30.

Department of Microbiology and Infectious Diseases, Nara Medical University, Nara, Japan. Electronic address:

Objective: To provide data on the molecular characteristics of extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae clinical isolates in Japan.

Methods: A total of 100 clinical isolates of ESBL-producing K. pneumoniae collected throughout Japan between June and July 2018 were studied. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.06.083DOI Listing

Relation between age and CT radiation doses: Dose trends in 705 pediatric head CT.

Eur J Radiol 2020 Jun 21;130:109138. Epub 2020 Jun 21.

Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Purpose: To evaluate the relationship between patient age and radiation doses associated with routine pediatric head CT performed with automatic tube potential selection and tube current modulation techniques.

Methods: We obtained patient demographics, scan parameters, and radiation dose descriptors (CT dose index volume -CTDIvol and dose length product -DLP) associated with consecutive routine head CT in 705 children (mean age 6.9 ± 5 years). Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109138DOI Listing

Three Photobiomodulation Protocols in the Prevention/Treatment of Radiotherapy-induced Oral Mucositis.

Photodiagnosis Photodyn Ther 2020 Jun 30:101906. Epub 2020 Jun 30.

Stomatology Department- A.C. Camargo Cancer Center, Sao Paulo, Brazil; Stomatology Department School of Dentistry, Sao Paulo University, Sao Paulo, Brazil. Electronic address:

Purpose: To compare three Photobiomodulation protocols to prevent/treat oral mucositis associated to radiotherapy.

Methods: Seventy-three patients with cancer in oral cavity, oropharynx, and nasopharynx, who underwent RT with dose in facial fields equal or higher than 6000 cGy were randomized into three groups (mean RT dose = 66 cGy ±4.9). Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101906DOI Listing

Biodegradable Magnesium versus Polylactide Pins for Radial Head Fracture Stabilization: A Biomechanical Study.

J Shoulder Elbow Surg 2020 Jun 30. Epub 2020 Jun 30.

Department of Orthopedics and Trauma Surgery, Medical Center - Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Germany; Department of Trauma Surgery, Asklepios Klinikum Hamburg, Germany.

Background: Biodegradable implants gain increasing importance for the fixation of simple displaced radial head fractures to supersede implant removal and to minimize cartilage destruction. Commonly used polylactide pins still lead to higher rates of secondary loss of reduction compared to metal implants. Alternatively, implants made from a magnesium alloy meanwhile are available in a pin design which hypothetically could perform superior to polylactide pins. Read More

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http://dx.doi.org/10.1016/j.jse.2020.06.007DOI Listing

Structural, ultrastructural, and immunohistochemical characteristics of the cell composition of the head kidney of grass carp (Ctenopharyngodon idella).

Authors:
Doaa M Mokhtar

Fish Shellfish Immunol 2020 Jun 30. Epub 2020 Jun 30.

Department of Anatomy and Histology, Faculty of Vet. Medicine, Assiut University, 71526, Egypt. Electronic address:

The head-kidney (HK) is a unique immune, hemopoietic, and endocrine organ in fish. Twenty fish were used to study the structure, ultrastructure, and immunohistochemistry of the HK of Grass carp. The HK of grass carp was consisted mainly of a network of hematopoietic cells with a few kidney tubules. Read More

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http://dx.doi.org/10.1016/j.fsi.2020.06.011DOI Listing

A Systematic Review and Meta-Analysis of Biceps Tenodesis Fixation Strengths: Fixation Type and Location Are Biomechanically Equivalent.

Arthroscopy 2020 Jun 30. Epub 2020 Jun 30.

Steadman Philippon Research Institute, Vail, CO; The Steadman Clinic, Vail, CO. Electronic address:

Purpose: The purpose of this meta-analysis and systematic review was to critically evaluate the biomechanical outcomes of different fixation constructs for a variety of biceps tenodesis techniques in cadaveric models based on both type of fixation as well as location.

Methods: A PROSPERO registered systematic review (CCRD42018109243) was conducted of the current literature with the terms "long head of biceps" AND "tenodesis" AND "biomechanics" and numerous variations thereof in PubMed, EMBASE, and Cochrane yielding 1460 abstracts. After screening by eligibility criteria, 18 full-text articles were included. Read More

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http://dx.doi.org/10.1016/j.arthro.2020.05.055DOI Listing

FOXN3 suppresses the growth and invasion of papillary thyroid cancer through the inactivation of Wnt/β-catenin pathway.

Mol Cell Endocrinol 2020 Jun 30:110925. Epub 2020 Jun 30.

Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China. Electronic address:

Forkhead box N3 (FOXN3) is a subtype of FOX family that has been demonstrated to be implicated in several cancers. However, the role of FOXN3 in papillary thyroid carcinoma (PTC) and its mechanisms have not yet been investigated. Our results showed that FOXN3 was markedly down regulated in PTC tissues and cell lines. Read More

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http://dx.doi.org/10.1016/j.mce.2020.110925DOI Listing

Measuring progress towards healthy working lives.

Lancet Public Health 2020 Jul;5(7):e366-e367

College of Human and Health Sciences, Centre for Innovative Ageing, Swansea University, UK.

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http://dx.doi.org/10.1016/S2468-2667(20)30141-9DOI Listing

SMARCB1 (Integrase Interactor 1)-Deficient Sinonasal Carcinoma of the Maxillary Sinus: A Newly Described Sinonasal Neoplasm.

J Oral Maxillofac Surg 2020 May 30. Epub 2020 May 30.

Associate Professor of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA.

SMARCB1 (integrase interactor 1) is a tumor suppressor gene encoded on chromosome 22q11.2 that encodes a core subunit of SWI/SNF chromatin remodeling complexes and plays a critical role in regulating gene expression and chromatin structure. We describe a case of SMARCB1 (integrase interactor 1)-deficient sinonasal carcinoma of the left maxillary sinus in a 63-year-old woman with an initial presentation of numbness of the maxillary teeth and facial swelling. Read More

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http://dx.doi.org/10.1016/j.joms.2020.05.033DOI Listing

Predictive coding in early vestibular pathways: Implications for vestibular cognition.

Cogn Neuropsychol 2020 Jul 3:1-4. Epub 2020 Jul 3.

Departments of Biomedical Engineering, Neuroscience, and Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1080/02643294.2020.1783222DOI Listing

Predictors of worsening neuropathy and neuropathic pain after 12 years in people with HIV.

Ann Clin Transl Neurol 2020 Jul 3. Epub 2020 Jul 3.

Departments of Medicine and Psychiatry, University of California, San Diego, La Jolla, California.

Objective: Distal sensory polyneuropathy (DSP) and neuropathic pain are important clinical concerns in virally suppressed people with HIV. We determined how these conditions evolved, what factors influenced their evolution, and their clinical impact.

Methods: Ambulatory, community-dwelling HIV seropositive individuals were recruited at six research centers. Read More

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http://dx.doi.org/10.1002/acn3.51097DOI Listing

Prevalence of Synchronous ESCN in Head and Neck Cancer: A Single-Institution Perspective.

Laryngoscope 2020 Jul 3. Epub 2020 Jul 3.

Department of Otolaryngology, Head and Neck Surgery, All India Institute of Medical Sciences New Delhi, Delhi, India.

Objectives: The primary objective was to determine the prevalence of synchronous esophageal squamous cell carcinoma in head and neck squamous cell carcinoma (HNSCC) patients. The secondary objective was to determine risk factors for the development of synchronous esophageal squamous cell carcinoma (ESCN).

Study Design: Cross sectional observation study. Read More

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http://dx.doi.org/10.1002/lary.28821DOI Listing

Medicare Reimbursement Trends for Facility Performed Otolaryngology Procedures: 2000-2019.

Laryngoscope 2020 Jul 3. Epub 2020 Jul 3.

Department of Otolaryngology, Mayo Clinic, Phoenix, Arizona, U.S.A.

Objective: There is a paucity of data regarding financial trends for procedural reimbursements in otolaryngology. The purpose of this study was to evaluate monetary trends in Medicare reimbursement rates for the 20 most commonly billed otolaryngology procedures from 2000 to 2019.

Study Design: Analysis of physician reimbursement. Read More

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http://dx.doi.org/10.1002/lary.28749DOI Listing

Proteomic and Genomic Methylation Signatures of Idiopathic Subglottic Stenosis.

Laryngoscope 2020 Jul 3. Epub 2020 Jul 3.

Division of Otolaryngology - Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, U.S.A.

Objective: Idiopathic subglottic stenosis (iSGS) is a chronic inflammatory condition that causes dyspnea and affects middle-aged women of White race and non-Latino or Hispanic ethnicity. To better characterize its phenotype and pathogenesis, we assessed the proteomic and genomic methylation signatures of subglottic tissue collected from iSGS patients compared to controls.

Study Design: Molecular analysis of clinical biospecimens. Read More

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http://dx.doi.org/10.1002/lary.28851DOI Listing

Dermatology residents and COVID-19: life behind the frontlines.

Clin Exp Dermatol 2020 Jul 3. Epub 2020 Jul 3.

Unit of Dermatology, Head and Neck Department, St. Orsola Malpighi University Hospital, Bologna, Italy.

the CoronaVirus Disease 2019 (COVID-19) pandemic outbreak in Italy completely changed patients' access to healthcare systems and therefore the doctor-patient relationship, in particular during the national lockdown (from March 11th to May 18th). Read More

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http://dx.doi.org/10.1111/ced.14365DOI Listing

Fatty Acid Conjugates of Toluidine Blue O as Amphiphilic Photosensitizers: Synthesis, Solubility, Photophysics, and Photochemical Properties.

Photochem Photobiol 2020 Jul 3. Epub 2020 Jul 3.

Laboratorio de Química Biosupramolecular, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Macul, Santiago, Chile.

Toluidine blue O (TBO) is a water-soluble photosensitizer that has been used in photodynamic antimicrobial and anticancer treatments, but suffers from limited solubility in hydrophobic media. In an effort to incrementally increase TBO's hydrophobicity, we describe the synthesis of hexanoic (TBOC6) and myristic (TBOC14) fatty acid derivatives of TBO formed in low to moderate percent yields by condensation with the free amine site. Covalently linking 6 and 14 carbon chains led to modifications of not only TBO's solubility, but also its photophysical and photochemical properties. Read More

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http://dx.doi.org/10.1111/php.13304DOI Listing

Does cup position differ between trabecular metal and titanium cups? A radiographic propensity score matched study of 300 hips.

Acta Orthop 2020 Jul 3:1-5. Epub 2020 Jul 3.

Swedish Hip Arthroplasty Register, Department of Orthopaedics, Institute of Surgical Sciences, Sahlgrenska University Hospital, Gothenburg, Sweden.

Background and purpose - The use of trabecular metal cups in primary total hip arthroplasty (THA) is increasing, despite the survival of Continuum cups being slightly inferior compared with other uncemented cups in registries. This difference is mainly explained by a higher rate of dislocation revisions. Cup malpositioning is a risk factor for dislocation and, being made of a highly porous material, Continuum cups might be more difficult to position. Read More

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http://dx.doi.org/10.1080/17453674.2020.1788290DOI Listing

Head-to-head comparison of the diagnostic accuracy of Xpert MTB/RIF and Xpert MTB/RIF Ultra for tuberculosis: a meta-analysis.

Infect Dis (Lond) 2020 Jul 3:1-13. Epub 2020 Jul 3.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

: Tuberculosis (TB) diagnosis has significantly improved since the introduction of the automated molecular test Xpert MTB/RIF (Xpert) and the new version Xpert MTB/RIF Ultra (Ultra) that detect . Due to the rapidly widespread use of Xpert and Ultra, we conducted a meta-analysis to compare the performances of Xpert and Ultra in diagnosing TB and discuss the advantages and limitations of these two tests.: Web of Science, Medline ( PubMed), Embase ( OvidSP), the Cochrane Central Register of Controlled Trials and Google Scholar (up to April 2020) were searched for relevant studies. Read More

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http://dx.doi.org/10.1080/23744235.2020.1788222DOI Listing

A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue.

J Pathol 2020 Jul 3. Epub 2020 Jul 3.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, US.

Activation of the nuclear factor (erythroid-derived 2)-like 2 (NFE2L2 or NRF2) transcription factor is a critical and evolutionarily conserved cellular response to oxidative stress, metabolic stress, and xenobiotic insult. Deficiency of NRF2 results in hypersensitivity to a variety of stressors, whereas its aberrant activation contributes to several cancer types, most commonly squamous cell carcinomas of the esophagus, oral cavity, bladder, and lung. Between 10 and 35% of patients with squamous cell carcinomas display hyperactive NRF2 signaling, harboring activating mutations and copy number amplifications of the NFE2L2 oncogene or inactivating mutations or deletions of KEAP1 or CUL3, the proteins of which co-complex to ubiquitylate and degrade NRF2 protein. Read More

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http://dx.doi.org/10.1002/path.5504DOI Listing

Implant Survival of 6,080 Tritanium Cups in Primary Total Hip Arthroplasty: Data from the Finnish Arthroplasty Register from 2009 to 2017.

J Bone Joint Surg Am 2020 Jul;102(13):1177-1185

Department of Orthopaedic Surgery (A.P., M.H., I.L., and K.T.M.) and the Turku PET Centre (M. Matilainen), University of Turku and Turku University Hospital, Turku, Finland.

Background: To enhance osseointegration in total hip arthroplasty (THA), ultraporous or highly porous-coated cups were introduced. Implant survival data on these new devices have been scarce. The aim of our study was to assess the survivorship of ultraporous Tritanium cups (Stryker) in a population-based register study. Read More

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http://dx.doi.org/10.2106/JBJS.19.00874DOI Listing

Blood pressure lability is associated with subcortical atrophy in early Parkinson's disease.

J Hypertens 2020 Jun 25. Epub 2020 Jun 25.

Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul.

Objective: Increased cerebral white matter intensities associated with blood pressure (BP) lability were reported in patients with Parkinson's disease. However, this type of cardiovascular dysautonomia has seldom been associated with disruptions in deep gray matter structures in Parkinson's disease. In the present study, the associations between BP lability and subcortical deep gray matter structures in early Parkinson's disease were evaluated. Read More

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http://dx.doi.org/10.1097/HJH.0000000000002505DOI Listing

The science of art: Leonardo Da Vinci and facial plastic surgery.

Authors:
David A Shaye

Curr Opin Otolaryngol Head Neck Surg 2020 Jun 28. Epub 2020 Jun 28.

Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: Leonardo Da Vinci possessed one of humanity's greatest minds, known for exploring the boundaries of art and science. The discipline of facial plastic surgery also relies on art and science for its advancement. This review focuses on key elements of Leonardo Da Vinci's work, and how they relate to concepts within facial plastic surgery. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000643DOI Listing

Update on evidence in craniomaxillofacial surgery.

Curr Opin Otolaryngol Head Neck Surg 2020 Jun 28. Epub 2020 Jun 28.

Department of Otolaryngology at SUNY Upstate Medical University, Syracuse, New York, USA.

Purpose Of Review: Evidence-based medicine underpins clinical practice. Ideally, our clinical decision-making stems from systematic reviews of randomized controlled trials. However, in practice, this is not often the case, and we must instead rely on the best available evidence. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000642DOI Listing

Advances in facial nerve management in the head and neck cancer patient.

Curr Opin Otolaryngol Head Neck Surg 2020 Jun 28. Epub 2020 Jun 28.

Division of Otolaryngology - Head and Neck Surgery, Department of Surgery, University of California San Diego, San Diego, California, USA.

Purpose Of Review: The purpose of this review is to summarize best practices in facial nerve management for patients with head and neck cancer. In addition, we provide a review of recent literature on novel innovations and techniques in facial reanimation surgery.

Recent Findings: Although recommended when tumor ablation surgery requires facial nerve sacrifice, facial reanimation procedures are not always performed. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000641DOI Listing

Gender affirming and aesthetic cranioplasty: what's new?

Curr Opin Otolaryngol Head Neck Surg 2020 Jun 28. Epub 2020 Jun 28.

Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology - Head and Neck Surgery, Boston University School of Medicine, The Spiegel Center, Newton, Massachusetts, USA.

Purpose Of Review: Esthetic cranioplasty is an important part of facial feminization surgery. Additionally, it is an often underappreciated procedure for facial beautification. This chapter reviews current trends in esthetic cranioplasty for transgender women and others. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000640DOI Listing

Minimally invasive techniques in rhinoplasty.

Curr Opin Otolaryngol Head Neck Surg 2020 Jun 28. Epub 2020 Jun 28.

ENT- Department of the Cantonal Hospital in St. Gallen, Switzerland.

Purpose Of Review: To present criteria of minimally invasive surgery, which include minimal and hidden incision lines, reduced injury to tissue and application of endoscopic techniques, when feasible; to analyze techniques in rhinoplasty for their minimally invasive character - in light of recent publications; and to discuss the techniques that best meet the criteria of minimally invasive surgery.

Recent Findings: The nose consists of about 60 percent soft tissue and 40 percent skeletal elements. Surgery causes injury to both tissue types through various mechanisms, including mechanical traction, separation, incision, heat, desiccation, and others. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000639DOI Listing

Recent developments in head and neck melanoma.

Curr Opin Otolaryngol Head Neck Surg 2020 Jun 28. Epub 2020 Jun 28.

Department of Otolaryngology, Head and Neck Surgery, SUNY Upstate Medical University, Syracuse, New York, USA.

Purpose Of Review: To provide an overview of recently published articles covering melanoma management of the head and neck region.

Recent Findings: Melanoma management represents a rapidly evolving field. The advent of immunotherapy has led to significant changes in diagnosis, treatment, and surveillance for these patients. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000633DOI Listing

Considerations for the otolaryngologist in the era of COVID-19: a review of the literature.

Curr Opin Otolaryngol Head Neck Surg 2020 Jun 28. Epub 2020 Jun 28.

Department of Otolaryngology - Head and Neck Surgery.

Purpose Of Review: The SARS-CoV-2 coronavirus pandemic, referred to as COVID-19, has spread throughout the globe since its first case in China in December 2019, leaving a significant number of people infected and clinically ill. The purpose of this review is to provide the current known clinical characteristics of and management for COVID-19 as it relates to otolaryngology.

Recent Findings: COVID-19 is a highly transmissible respiratory disease with common presenting symptoms of fever, cough, and fatigue. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000632DOI Listing

Optimizing septal perforation repair techniques.

Curr Opin Otolaryngol Head Neck Surg 2020 Jun 28. Epub 2020 Jun 28.

Department of Otolaryngology-Head and Neck Surgery.

Purpose Of Review: Multiple successful techniques and approaches for nasal septal perforation repair have been described, yet consistency in perforation and outcome metrics is required to identify the optimal approach to repair. The present article will review the recent literature.

Recent Findings: Computational fluid dynamic studies continue to expand our understanding of the airflow dynamics in nasal septal perforation and after repair. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000631DOI Listing

Reversible Cerebral Vasoconstriction Syndrome Following Carotid Endarterectomy: A Case Report.

Neurologist 2020 Jul;25(4):104-105

Lehigh Valley Health Network, Allentown, PA.

Introduction: Reversible cerebral vasoconstriction syndrome (RCVS) is a cerebrovascular disorder associated with multifocal intracranial arterial constriction and dilation that occurs spontaneously or as a result of a stimulant. The authors present a case of RCVS in a patient who presented with a new-onset thunderclap headache a day after carotid endarterectomy (CEA). RCVS has been rarely reported after CEA. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000280DOI Listing

Patient Reported Outcomes of Femoral Head Fractures With Minimum 10-Year Follow-up.

J Orthop Trauma 2020 Jun 26. Epub 2020 Jun 26.

Hennepin County Medical Center, Minneapolis, MN, USA.

Objective: To evaluate the clinical and patient-reported outcomes of patients with femoral head fractures treated at a single level I trauma center with a minimum 10-year follow-up.

Design: Retrospective review SETTING:: Academic Level-1 Trauma Center PATIENTS/PARTICIPANTS:: One hundred and one consecutive femoral head fractures were identified for this study. The final study group consisted of 28 patients with a minimum of 10-years of clinical follow-up. Read More

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http://dx.doi.org/10.1097/BOT.0000000000001880DOI Listing

Disc-fovea Angle is Associated with Visual Field Defect Location in Patients with Glaucoma.

J Glaucoma 2020 Jun 30. Epub 2020 Jun 30.

Department of Ophthalmology, Otorhinolaryngology and Head Neck Surgery, Ribeirao Preto Medical School - University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

PRéCIS:: The current study showed that glaucomatous eyes from patients with central visual field defects presented less negative disc-fovea angle compared to patients with peripheral defects.

Purpose: To investigate the relationship between disc-fovea angle and visual field location in patients with glaucoma.

Methods: Cross-sectional study including glaucoma patients divided into isolated central and isolated peripheral scotoma groups. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001595DOI Listing

Apolipoprotein E ε4 and cognitive function after surgery in middle-aged and elderly Danish twins.

Eur J Anaesthesiol 2020 Jun 30. Epub 2020 Jun 30.

From the The Unit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, Danish Twin Registry, Danish Aging Research Center, University of Southern Denmark (UD, MW, MT, KC, JM-F), Department of Anaesthesiology and Intensive Care Medicine, Odense University Hospital, Odense (TGH), Department of Anaesthesia, Centre of Head and Orthopaedics, Rigshospitalet, University of Copenhagen, Copenhagen (LSR), Clinical Biochemistry and Pharmacology (KC) and Clinical Genetics, Odense University Hospital, Odense, Denmark (KC, JM-F).

Background: Transient cognitive impairment is common in adult patients of all ages following anaesthesia and surgery. Apolipoprotein E (APOE) ε4 carriers may have a larger deterioration in short-term cognitive function after major surgery compared with APOE ε4 noncarriers.

Objectives: The aim was to examine the effect of APOE ε4 on the association between exposure to surgery and anaesthesia, and subsequent cognitive functioning. Read More

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http://dx.doi.org/10.1097/EJA.0000000000001250DOI Listing

Recent advances in orthognathic surgery.

Curr Opin Otolaryngol Head Neck Surg 2020 Aug;28(4):246-250

Texas Center for Facial Plastic and Laser Surgery, San Antonio, Texas.

Purpose Of Review: The aim of this article is to review the recent literature on orthognathic surgery for treatment of malocclusion and obstructive sleep apnea (OSA). The discussion outlines the refinements of the procedure and advances in technology.

Recent Findings: Maxillomandibular advancement (MMA) may be performed for complex malocclusion and OSA. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000638DOI Listing

Effects of Head Movements on Sound-Source Localization in Single-Sided Deaf Patients With Their Cochlear Implant On Versus Off.

Ear Hear 2020 Jun 30. Epub 2020 Jun 30.

College of Health Solutions, Arizona State University, Tempe, Arizona, USA.

Objectives: We investigated the ability of single-sided deaf listeners implanted with a cochlear implant (SSD-CI) to (1) determine the front-back and left-right location of sound sources presented from loudspeakers surrounding the listener and (2) use small head rotations to further improve their localization performance. The resulting behavioral data were used for further analyses investigating the value of so-called "monaural" spectral shape cues for front-back sound source localization.

Design: Eight SSD-CI patients were tested with their cochlear implant (CI) on and off. Read More

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http://dx.doi.org/10.1097/AUD.0000000000000882DOI Listing

The Effect of High-Flow Nasal Oxygen on Carbon Dioxide Accumulation in Apneic or Spontaneously Breathing Adults During Airway Surgery: A Randomized-Controlled Trial.

Anesth Analg 2020 Jun 30. Epub 2020 Jun 30.

From the Department of Anaesthesia, Princess Alexandra Hospital-Southern Clinical School, Faculty of Medicine, The University of Queensland, Brisbane, Australia.

Background: High-flow nasal oxygen (HFNO) is an emerging technology that has generated interest in tubeless anesthesia for airway surgery. HFNO has been shown to maintain oxygenation and CO2 clearance in spontaneously breathing patients and is an effective approach to apneic oxygenation. Although it has been suggested that HFNO can enhance CO2 clearance during apnea, this has not been established. Read More

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http://dx.doi.org/10.1213/ANE.0000000000005002DOI Listing

Retention of Monoblock Femoral Components Using a Dual Mobility Bearing: A Report of 3 Cases.

JBJS Case Connect 2020 Jul-Sep;10(3):e1900641

Department of Trauma and Orthopaedics, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, United Kingdom.

Case: We present the results of 3 cases followed up for a minimum period of 4.5 years of revision total hip arthroplasty using a metal acetabular shell with retention of a well-fixed monoblock femoral component by inserting a dual mobility polyethylene bearing onto the femoral head in situ.

Conclusion: This is the first case series to use this technique to address acetabular osteolysis and avoid removing a well-fixed monoblock femoral component at the time of revision surgery. Read More

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http://dx.doi.org/10.2106/JBJS.CC.19.00641DOI Listing

Head and Brain Postmortem Computed Tomography-Autopsy Correlation in Hospital Deaths.

Am J Forensic Med Pathol 2020 Jun 30. Epub 2020 Jun 30.

From the Department of Pathology.

The use of postmortem computed tomography (PMCT) to support autopsy pathology has increased in recent decades. To some extent, PMCT has also been contemplated as a potential alternative to conventional postmortem examination. The purpose of this study was to investigate the ability of PMCT to detect specific pathologic findings in the head and brain in natural hospital deaths. Read More

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http://dx.doi.org/10.1097/PAF.0000000000000538DOI Listing

Radiotherapy for Adult Soft Tissue Sarcomas of the Head and Neck.

Am J Clin Oncol 2020 Jun 30. Epub 2020 Jun 30.

Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL.

Objective: Surgery followed by postoperative radiation therapy (RT) is the standard of care for soft tissue sarcomas (STS) of the head and neck that are high grade or have close or positive margins.

Methods: The authors retrospectively reviewed adult patients with head and neck STS treated with RT at a single institution between 1981 and 2017. All patients who were 19 years and older with STS of the head and neck-excluding rhabdomyosarcoma, angiosarcoma, and Ewing tumors-were included in this study. Read More

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http://dx.doi.org/10.1097/COC.0000000000000729DOI Listing

Pseudo mastoid obliteration with conchal cartilage may be a safe alternative technique for cochlear implantation in canal wall down mastoidectomy with large meatoplasty.

J Laryngol Otol 2020 Jun 19:1-4. Epub 2020 Jun 19.

Otorhinolaryngology, Head and Neck Surgery Department, Son Espases University Hospital, Palma de Mallorca, Spain.

Objective: Safe cochlear implantation is challenging in patients with canal wall down mastoid cavities, and the presence of large meatoplasties increases the risk of external canal overclosure. This paper describes our results of obliteration of the mastoid cavity with conchal cartilage as an alternative procedure in cases of canal wall down mastoidectomy with very large meatoplasty.

Methods: The cases of seven patients with a canal wall down mastoidectomy cavity who underwent cochlear implantation were retrospectively reviewed. Read More

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http://dx.doi.org/10.1017/S0022215120001139DOI Listing

Protecting prone positioned patients from facial pressure ulcers using prophylactic dressings: A timely biomechanical analysis in the context of the COVID-19 pandemic.

Int Wound J 2020 Jul 3. Epub 2020 Jul 3.

Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel.

Prone positioning is used for surgical access and recently in exponentially growing numbers of coronavirus disease 2019 patients who are ventilated prone. To reduce their facial pressure ulcer risk, prophylactic dressings can be used; however, the biomechanical efficacy of this intervention has not been studied yet. We, therefore, evaluated facial soft tissue exposures to sustained mechanical loads in a prone position, with versus without multi-layered silicone foam dressings applied as tissue protectors at the forehead and chin. Read More

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http://dx.doi.org/10.1111/iwj.13435DOI Listing

Atypical Fibroxanthoma - An Analysis of 105 Tumors.

Dermatol Ther 2020 Jul 3:e13962. Epub 2020 Jul 3.

Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Dresden, Germany.

Background: Atypical fibroxanthoma (AFX) is a rare, low-grade dermal sarcoma.

Patients And Methods: We analyzed our files from January 2001 to January 2020 for AFX. Clinical parameters, histopathology, treatment and outcome have been investigated. Read More

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http://dx.doi.org/10.1111/dth.13962DOI Listing
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