691,989 results match your criteria Head and Neck Carcinoma in the Young Patient


Clinical predictors of poor 30-day headache outcomes after an emergency department visit for acute post-traumatic headache.

Am J Emerg Med 2021 Jun 9;49:158-162. Epub 2021 Jun 9.

Department of Emergency Medicine, Albert Einstein College of Medicine, Montefiore, 111 East 210th Street, Bronx, NY 10467, USA. Electronic address:

Purpose: We investigated clinical risk factors that predict poor 30-day headache outcomes among patients evaluated in the emergency department (ED) for post-traumatic headache (PTH).

Methods: This was an analysis of data from a randomized, placebo-controlled study of IV metoclopramide + diphenhydramine for acute PTH. Patients were enrolled during an ED visit and received telephone follow-up with a structured questionnaire 30 days later. Read More

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Prognostic value of tumor mutational burden in patients with oral cavity squamous cell carcinoma treated with upfront surgery.

ESMO Open 2021 Jun 9;6(4):100178. Epub 2021 Jun 9.

Department of Drug Development and Innovation (D3i), Institut Curie, Paris and Saint-Cloud, France. Electronic address:

Background: Oral cavity is the most prevalent site of head and neck squamous cell carcinomas (HNSCCs). Most often diagnosed at a locally advanced stage, treatment is multimodal with surgery as the cornerstone. The aim of this study was to explore the molecular landscape of a homogenous cohort of oral cavity squamous cell carcinomas (OCSCCs), and to assess the prognostic value of tumor mutational burden (TMB), along with classical molecular and clinical parameters. Read More

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Nonlinear dynamics for the spread of pathogenesis of COVID-19 pandemic.

J Infect Public Health 2021 Apr 20;14(7):817-831. Epub 2021 Apr 20.

University School of Basic & Applied Sciences (USBAS), Head, Non-Linear Dynamics-Research-Lab, GGS Indraprastha University, New Delhi, India. Electronic address:

Coronaviruses did not invite attention at a global level and responsiveness until the series of 2003-SARS contagion followed by year-2012 MERS plus, most recently, 2019-nCoV eruptions. SARS-CoV &MERS-CoV are painstaking, extremely pathogenic. Also, very evidently, both have been communicated from bats to palm-civets & dromedary camels and further transferred ultimately to humans. Read More

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High throughput proteomic and metabolic profiling identified target correction of metabolic abnormalities as a novel therapeutic approach in head and neck paraganglioma.

Transl Oncol 2021 Jun 9;14(8):101146. Epub 2021 Jun 9.

Department of Otolaryngology Head & Neck Surgery, The Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, No. 639, Zhi-Zao-Ju Road, Shanghai 200011, China; Ear Institute, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China. Electronic address:

Head and neck paragangliomas (HNPGLs) are rare neoplasms that represent difficult treatment paradigms in neurotology. Germline mutations in genes encoding succinate dehydrogenase (SDH) are the cause of nearly all familial HNPGLs. However, the molecular mechanisms underlying tumorigenesis remain unclear. Read More

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Health of African refugee children outside Africa: A scoping review.

J Pediatr Nurs 2021 Jun 9;61:199-206. Epub 2021 Jun 9.

Department of Educational Psychology, University of Alberta, Edmonton, Alberta T6G 2G5, Canada. Electronic address:

Problem: Africa is the largest source continent of refugee children. However, we found no published synthesis of the literature on the health of African refugee children outside Africa. Conducting a review of the literature on this particular population will help illuminate the particular contextual health issues faced by African child refugees who live outside Africa. Read More

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Hirschsprung disease with Edward syndrome: A rare association: A case report.

Int J Surg Case Rep 2021 Jun 9;84:106084. Epub 2021 Jun 9.

Department of GI and General Surgery, Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal. Electronic address:

Introduction And Importance: Edward's syndrome (ES) occurs as a result of trisomy of chromosome 18 and is associated with multisystem congenital anomalies. The association of ES with various gastrointestinal malformations but Hirschsprung disease (HD) is well documented.

Case Presentation: A female infant on her 5th day of life presented with episodes of bilious vomiting along with abdominal distension and no passage of stool. Read More

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Listening effort and fatigue in native and non-native primary school children.

J Exp Child Psychol 2021 Jun 9;210:105203. Epub 2021 Jun 9.

Department of Psychology, Lund University, 221 00 Lund, Sweden. Electronic address:

Background noise makes listening effortful and may lead to fatigue. This may compromise classroom learning, especially for children with a non-native background. In the current study, we used pupillometry to investigate listening effort and fatigue during listening comprehension under typical (0 dB signal-to-noise ratio [SNR]) and favorable (+10 dB SNR) listening conditions in 63 Swedish primary school children (7-9 years of age) performing a narrative speech-picture verification task. Read More

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A homozygous nonsense mutation early in exon 5 of BRCA2 is associated with very severe Fanconi anemia.

Eur J Med Genet 2021 Jun 9:104260. Epub 2021 Jun 9.

Department of Pediatrics III, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany; Department of Otorhinolaryngology & Head/Neck Surgery, University Hospital Düsseldorf, Heinrich Heine University, 40225 Düsseldorf, Germany. Electronic address:

Fanconi anemia (FA) due to biallelic mutations in the BRCA2 gene is very rare and associated with an extremely high risk of early-onset of aggressive childhood malignancies, predominantly brain tumors, leukemia, and nephroblastoma. Here, we present a consanguineous family with three affected children of the D1 subtype of FA and describe the clinical consequences of the earliest known biallelic nonsense/stop-gain germ-line mutation in BRCA2, exon 5 c.469A>T, that leads to a premature stop of translation, p. Read More

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Reply to "Commentary on: Risk factors for postoperative morbidity after thyroid surgery in a PROSPECTIVE cohort of 1500 patients (Int. J. Surg. 2021, Epub ahead of print)".

Int J Surg 2021 Jun 9:105994. Epub 2021 Jun 9.

Centre for Translational Microbiome Research Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, Stockholm, Sweden; Global Health Institute, University of Antwerp, Wilrijk, Belgium.

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A 48-Channel Receive Array Coil for Mesoscopic Diffusion-Weighted MRI of ex vivo Human Brain on the 3 T Connectome Scanner.

Neuroimage 2021 Jun 9:118256. Epub 2021 Jun 9.

Institute of Medical Physics and Radiation Protection (IMPS), TH-Mittelhessen University of Applied Sciences (THM), Giessen, Germany; Center for Mind, Brain and Behavior (CMBB), Marburg, Germany.

In vivo diffusion-weighted magnetic resonance imaging is limited in signal-to-noise-ratio (SNR) and acquisition time, which constrains spatial resolution to the macroscale regime. Ex vivo imaging, which allows for arbitrarily long scan times, is critical for exploring human brain structure in the mesoscale regime without loss of SNR. Standard head array coils designed for patients are sub-optimal for imaging ex vivo whole brain specimens. Read More

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Expression profiling, immune functions, and molecular characteristics of the tetraspanin molecule CD63 from Amphiprion clarkii.

Dev Comp Immunol 2021 Jun 9:104168. Epub 2021 Jun 9.

Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju 63333, Republic of Korea. Electronic address:

CD63, a member of the tetraspanin family, is involved in the activation of immune cells, antiviral immunity, and signal transduction. The economically important anemonefishes Amphiprion sp. often face disease outbreaks, and the present study aimed to characterize CD63 in Amphiprion clarkii (denoted AcCD63) to enable better disease management. Read More

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Successful perioperative management of a primary pulmonary arterial angiosarcoma - Case report.

Braz J Anesthesiol 2021 Jun 9. Epub 2021 Jun 9.

Hospital Universitari Son Espases, Cardiovascular Surgery, Quiron Clinica Rotger and Head of Service, Lead Consultant Cardiac Surgeon, Palma de Mallorca, Spain.

Introduction: Primary pleomorphic pulmonary angiosarcomas are extremely rare tumors which could be easily mistaken for pulmonary emboli.

Background And Findings: We describe the successful perioperative management of a patient with a pulmonary arterial mass which turned out to be a primary pulmonary angiosarcoma. The severe pulmonary hypertension was a particular challenge compounded with the site and adhesions of the tumor, and pulmonary hemorrhage. Read More

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Circulating microRNA profile in humans and mice with congenital GH deficiency.

Aging Cell 2021 Jun 12:e13420. Epub 2021 Jun 12.

Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA.

Reduced inflammation, increased insulin sensitivity, and protection against cancer are shared between humans and mice with GH/IGF1 deficiency. Beyond hormone levels, miRNAs are important regulators of metabolic changes associated with healthy aging. We hypothesized that GH deficiency in humans alters the abundance of circulating miRNAs and that a subset of those miRNAs may overlap with those found in GH-deficient mice. Read More

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Nasogastric Tube Insertion in intubated patients with the guide of Wire rope: A Prospective Randomized Controlled Study.

Int J Clin Pract 2021 Jun 12:e14508. Epub 2021 Jun 12.

Department of Anesthesiology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Nasogastric tube (NGT) insertion is sometimes required in intubated patients. NGTs are prone to kink and coil during blind insertion. We hypothesized that Wire rope guide-assisted NGT insertion with chin lift can significantly improve the first-attempt success rate over the conventional technique during its insertion in intubated patients. Read More

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Oxidative formation of bis-N-methylquinolinone from anti-head-to-head N-methylquinolinone cyclodimer.

Photochem Photobiol Sci 2021 Jun 12. Epub 2021 Jun 12.

Department of Chemistry, Philipps-Universität Marburg, Hans-Meerwein-Straße 4, 35032, Marburg, Germany.

The light-driven formation and cleavage of cyclobutane structural motifs resulting from [2 + 2]-pericyclic reactions, as found in thymine and coumarin-type systems, is an important and intensively studied photochemical reaction. Various applications are reported utilizing these systems, among others, in cross-linked polymers, light-triggered drug release, or other technical applications. Herein coumarin is most frequently used as the photoactive group. Read More

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Human papillomavirus in Italy: retrospective cohort analysis and preliminary vaccination effect from real-world data.

Eur J Health Econ 2021 Jun 12. Epub 2021 Jun 12.

Institute for Leadership and Management in Health, Kingston University London, London, UK.

Introduction: The objective of this study was to estimate the lifetime risk of hospitalization associated with all major human papillomavirus (HPV)-related diseases in Italy. Moreover, a preliminary vaccination effect was also performed.

Methods: A retrospective, nonrandomized, observational study was developed based on patients hospitalized between 2006 and 2018 in Italy. Read More

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Review of personal radiation exposure dose and history of the interventional procedure records for 40 years.

Jpn J Radiol 2021 Jun 12. Epub 2021 Jun 12.

Department of the Diagnostic and Interventional Radiology, Nasu Red Cross Hospital, 1081-4, Nakadawara, Ohtawara, Tochigi, 324-8686, Japan.

Objective: To inspect personal dose as an interventional radiologist for 40 years, to assess the enforcement number of interventional radiology (IR), and to check for radiation cataract.

Materials And Methods: I evaluated my own effective dose, an equivalent dose to the lens of the eye (EDL), and the number of IR procedures between March 2019 and June 1979. I examined the lens in June 2019 as a radiologist for 40 years. Read More

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Prepancreatic common hepatic artery arising from superior mesenteric artery: an exceptional but important finding during pancreaticoduodenectomy.

Surg Radiol Anat 2021 Jun 12. Epub 2021 Jun 12.

HPB Unit, Digestive Surgery Department, Nouvel Hopital Civil, University of Strasbourg, 1 Place de l'Hôpital, 67091, Strasbourg, France.

Purpose: The hepato-mesenteric trunk is an extremely rare condition in which the common hepatic artery (CHA) originates from the superior mesenteric artery (SMA). Usually, CHA passes behind the head of the pancreas. A systematic review was performed to provide guidelines for the perioperative management of patients with this anatomical variation who underwent a pancreaticoduodenectomy (PD). Read More

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Treatment of juvenile recurrent parotitis with irrigation therapy without anesthesia.

Eur Arch Otorhinolaryngol 2021 Jun 12. Epub 2021 Jun 12.

Department of Otolaryngology, Head and Neck Surgery, Philipps-University, Marburg, 35043, Baldingerstraße, Germany.

Purpose: No standardized treatment regimen exists for juvenile recurrent parotitis (JRP). The investigators hypothesized that irrigation with saline only without local anesthesia will be an effective and beneficial option.

Methods: Using a retrospective study design, a series of children with typical symptoms of JRP who were treated with at least one irrigation therapy were evaluated. Read More

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What do surgeons need to know about the mesopancreas.

Langenbecks Arch Surg 2021 Jun 12. Epub 2021 Jun 12.

Department of Gastrointestinal Surgery, Hepatopancreatobiliary Unit, Presidente Dutra Hospital, São Luiz, Brazil.

Background: Pancreatoduodenectomy is the only treatment with a promise of cure for patients with pancreatic head adenocarcinoma, and a negative resection margin is an important factor related to overall survival. Complete clearance of the medial margin with removal of the so-called mesopancreas may decrease the recurrence rate after pancreatic resection. Here, we present some important information about the mesopancreas, total mesopancreas excision, and technical aspects to achieve negative resection margins. Read More

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Constitutive Hedgehog/GLI2 signaling drives extracutaneous basaloid squamous cell carcinoma development and bone remodeling.

Carcinogenesis 2021 Jun 12. Epub 2021 Jun 12.

Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.

Uncontrolled activation of the Hedgehog (Hh) signaling pathway, operating through GLI transcription factors, plays a central role in the pathogenesis of cutaneous basal cell carcinoma and contributes to the development of several malignancies arising in extracutaneous sites. We now report that K5-tTA;tetO-Gli2 bitransgenic mice develop distinctive epithelial tumors within their jaws. These tumors consist of large masses of highly proliferative, monomorphous, basaloid cells with scattered foci of keratinization and central necrosis, mimicking human basaloid squamous cell carcinoma (BSCC), an aggressive upper aerodigestive tract tumor. Read More

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Impact of Adjuvant Medical Therapies on Surgical Outcomes in Idiopathic Subglottic Stenosis.

Laryngoscope 2021 Jun 12. Epub 2021 Jun 12.

Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, U.S.A.

Objectives/hypothesis: Adjuvant medications including proton pump inhibitors (PPI), antibiotics (trimethoprim/sulfamethoxazole [TMP-SMX]), and inhaled corticosteroids (ICS) may be prescribed for patients with idiopathic subglottic stenosis (iSGS). We describe medication use with endoscopic dilation (ED) or endoscopic resection with medical treatment (ERMT) and evaluate impact on outcomes.

Study Design: International, prospective, 3-year multicenter cohort study of 810 patients with untreated, newly diagnosed, or previously treated iSGS. Read More

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Sinonasal adenocarcinoma: A population-based analysis of demographic and socioeconomic disparities.

Head Neck 2021 Jun 12. Epub 2021 Jun 12.

Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Background: Sinonasal adenocarcinoma (SNAC) is a rare tumor. The impact of health disparities on survival, stage at presentation, and utilization of surgery is not well understood in patients with SNAC.

Methods: The Surveillance, Epidemiology, and End Results database was queried for cases of SNAC from 1973 to 2015. Read More

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Bleeding complications in patients with squamous cell carcinoma of the head and neck.

Head Neck 2021 Jun 12. Epub 2021 Jun 12.

Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Hemorrhage in recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) may be attributed to chemotherapy and local tumor irradiation. Evidence of the relationship between hemorrhage in R/M HNSCC and targeted therapies, including epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) inhibitors, or immune checkpoint inhibitors, is limited. We aimed to identify epidemiological and clinical data related to the occurrence of hemorrhage in R/M HNSCC and to explore its relationship with various therapies. Read More

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Pignat's vertical partial laryngectomy with crico-hyoido-epiglotto-plasty.

Eur Arch Otorhinolaryngol 2021 Jun 11. Epub 2021 Jun 11.

Otorhinolaryngology Division, Leon Berard Cancer Center, Lyon, France.

Purpose: Pignat's partial laryngectomy with crico-hyoido-epiglotto-plasty (CHEPL) is a vertical laryngectomy with resection of the anterior portion of the thyroid cartilage and reconstruction with a wires net and the subhyoid muscles. The aim of this retrospective study was to evaluate and analyze oncologic and functional outcomes in patients affected by laryngeal squamous cell carcinoma and treated with Pignat's partial laryngectomy.

Methods: Seventy patients with cT1-cT3 glottic cancer were surgically treated with Pignat's technique. Read More

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Swallowing Exercise During Head and Neck Cancer Treatment: Results of a Randomized Trial.

Dysphagia 2021 Jun 11. Epub 2021 Jun 11.

Cancer Late Effects Research Unit (CASTLE), Department of Oncology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.

The diagnosis and treatment of head and neck cancer (HNC) can have substantial impact on swallowing function, nutritional balance, physical function and quality of life (QoL). Early initiated swallowing exercises are hypothesized to improve swallowing function in HNC patients. The aim was to investigate the effects of swallowing exercises and progressive resistance training (PRT) during radiotherapy on swallowing function, physical function and QoL in patients with pharynx-, larynx-, oral cavity cancer or unknown primary compared to usual care. Read More

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Correction to: Doppler Ultrasonographic Anatomy of the Midline Nasal Dorsum.

Aesthetic Plast Surg 2021 Jun 11. Epub 2021 Jun 11.

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Banpo-daero 222, Seocho-gu, Seoul, 06591, Korea.

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Head-to-head comparison of (R)-[C]verapamil and [F]MC225 in non-human primates, tracers for measuring P-glycoprotein function.

Eur J Nucl Med Mol Imaging 2021 Jun 11. Epub 2021 Jun 11.

Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.

Purpose: P-glycoprotein (P-gp) function is altered in several brain disorders; thus, it is of interest to monitor the P-gp function in vivo using PET. (R)-[C]verapamil is considered the gold standard tracer to measure the P-gp function; however, it presents some drawbacks that limit its use. New P-gp tracers have been developed with improved properties, such as [F]MC225. Read More

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Morrison dental chair.

Authors:
Rachel Bairsto

Br Dent J 2021 Jun;230(11):697

Head of Museum Services, British Dental Association Museum, UK.

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