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Sr Care Pharm 2022 Jul;37(7):260-265

1The Peter Lamy Center on Drug therapy and Aging, University of Maryland, School of Pharmacy, Baltimore, Maryland.

The purpose of this manuscript is to provide pharmacists with education on hearing loss that colleagues in audiology believe is most critical for pharmacists. As well as highlighting insightful interventions pharmacists can make in collaboration with hearing professionals, such as audiologists, otolaryngologists, and otologists, to improve patient care. This project was initiated by professional students at the University of Maryland in both Baltimore and College Park campuses, after completing the interprofessional elective course IPE Care in Geriatrics. Read More

BMC Med Educ 2022 Jun 26;22(1):498. Epub 2022 Jun 26.

Department of Digital Medicine, College of Biomedical Engineering and Medical Imaging, Third Military Medical University (Army Medical University), No. 30, Gaotanyan Street, Shapingba District, 400038, Chongqing, China.

Background: Effective first aid on the battlefield is vital to minimize deaths caused by war trauma and improve combat effectiveness. However, it is difficult for junior medical students, which have relatively poor human anatomy knowledge and first aid experience. Therefore, we aim to create a treatment simulation software for war trauma, and to explore its application for first aid training. Read More

Clin Transl Oncol 2022 Jun 25. Epub 2022 Jun 25.

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Endometrial cancer (EC) is one of the most common tumors in the female reproductive system, which seriously threatens women's health, particularly in developed countries. 13% of the patients with EC have a poor prognosis due to recurrence and metastasis. Therefore, identifying good predictive biomarkers and therapeutic targets is critical to enable the early detection of metastasis and improve the prognosis. Read More

Clin Transl Oncol 2022 Jun 25. Epub 2022 Jun 25.

Otorhinolaryngology Department, Hospital del Mar, Barcelona, Spain.

Purpose: FNDC4 gene encodes the fibronectin type III domain-containing 4 protein. Elevated expression of FNDC4 has been associated with poor prognosis in several types of cancer. There are no studies that have evaluated the prognostic capacity of FNDC4 in patients with head and neck cancer (HNSCC). Read More

Pediatr Res 2022 Jun 25. Epub 2022 Jun 25.

Division of Neonatology, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA.

Background: The aim of this study was to compare the impact of a semi-upright swing with a standard crib on vital signs in infants in the neonatal intensive care unit (NICU).

Methods: We performed a within-subjects' comparison of vital signs of NICU infants corrected to ≥34 weeks of gestation and placed in the supine position versus the semi-upright position in a swing. The primary outcome was the mean oxygen saturation, and the secondary outcomes were the mean heart rate, the proportion of time with oxygen saturation (SpO) <90%, and respiratory rate. Read More

Arch Virol 2022 Jun 25. Epub 2022 Jun 25.

College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China.

Little is known about the prophages in Hafniaceae bacteria. A novel Hafnia phage, yong2, was induced from Hafnia paralvei by treatment with mitomycin C. The phage has an elliptical head with dimensions of approximately 45 × 38 nm and a long noncontractile tail of approximately 157 × 4 nm. Read More

Radiol Med 2022 Jun 25. Epub 2022 Jun 25.

Radiation Oncology, Azienda Ospedaliero-Universitaria Careggi, University of Florence, largo Brambilla 3, 50134, Florence, Italy.

The advent of immune checkpoint inhibitors for recurrent/metastatic head and neck squamous cell carcinoma (RM-HNSCC) has revolutionized the standard of care approach in first-line treatment. The heterogeneity of disease presentation and treatment-related toxicities can be associated with suboptimal patient compliance to oncologic care. Hence, prioritizing quality of life and well-being are crucial aspects to be considered in tailoring the best treatment choice. Read More

Nat Commun 2022 Jun 25;13(1):3640. Epub 2022 Jun 25.

Department of Pediatrics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.

Systematic SARS-CoV-2 testing is a valuable tool for infection control and surveillance. However, broad application of high sensitive RT-qPCR testing in children is often hampered due to unpleasant sample collection, limited RT-qPCR capacities and high costs. Here, we developed a high-throughput approach ('Lolli-Method') for SARS-CoV-2 detection in children, combining non-invasive sample collection with an RT-qPCR-pool testing strategy. Read More

J Plast Reconstr Aesthet Surg 2022 May 6. Epub 2022 May 6.

Section of Plastic and Reconstructive Surgery, Memorial Sloan Kettering Cancer Center, NY, USA; Head and Neck Service, Memorial Sloan Kettering Cancer Center, NY, USA. Electronic address:

Introduction There is currently no consensus as to the comparative complication profiles of mini-plate (MP) and reconstruction bar (RB) osseous fixation in fibula flap mandibular reconstruction. The aim of this study is to compare complication rates associated with the use of MP versus RB fixation for vascularized fibula free flap (FFF) reconstruction of oncologic mandibular defects in an effort to better guide hardware utilization and pre-operative virtual surgical planning methods. Methods A systematic review and meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Read More

J Foot Ankle Surg 2022 Mar 12. Epub 2022 Mar 12.

Department of Orthopedic Surgery, Hospital Santa Helena, Brasília, DF, Brazil. Electronic address:

We investigated the potential of exogenous hyaluronic acid (HA) associated with corticosteroid injections to improve pain and function for the treatment of post-traumatic subtalar osteoarthritis, in comparison with isolated intra-articular corticosteroid. Twenty-five symptomatic participants (50 ± 8 years) with a minimum follow-up of 1 year after surgery for calcaneus fractures were enrolled. Participants were randomly assigned into a therapeutic group that underwent isolated corticosteroid intra-articular subtalar injection (Corticosteroid Group, n = 12) or a combination of HA plus corticosteroid (HA+C Group, n = 13). Read More

Oral Maxillofac Surg Clin North Am 2022 Jun 22. Epub 2022 Jun 22.

Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA.

The prevalence of sagittal and lambdoid suture craniosynostosis differs considerably, as they are notably the most and least prevalent sutures involved in isolated suture craniosynostosis, respectively. The goals of reconstructing the cranial vault in both entities is the same: to release the fused suture, expand cranial volume, restore normal head shape and morphology, and allow for normal growth of the cranial vault. With regards to sagittal suture synostosis, opinions vary on whether reconstruction should focus on either the anterior or poster cranial vault. Read More

J Voice 2022 Jun 22. Epub 2022 Jun 22.

GZA Sint-Augustinus, Department of Otorhinolaryngology and Head & Neck Surgery, European Institute of ORL-HNS, Antwerp, Belgium; Ghent University, Faculty of Medicine and Health Sciences, Department of Rehabilitation Sciences, Ghent, Belgium; University College Ghent, Department of Speech-Language Therapy and Audiology, Ghent, Belgium; Université Catholique de Louvain, Faculty of Psychology and Pedagogical Sciences, School of Logopedics, Ottignies-Louvain-La-Neuve, Belgium; Phonanium, Lokeren, Belgium. Electronic address:

Background: Acoustic measurements are useful tools to objectively measure overall voice quality. The Acoustic Voice Quality Index (AVQI) has shown to be a valid multiparametric tool to objectify dysphonia severity. The increasing number of validity studies investigating AVQI's validity demands a comprehensive synthesis of the available outcomes. Read More

Ann Emerg Med 2022 Jun 22. Epub 2022 Jun 22.

University of Utah School of Medicine, Salt Lake City, UT.

Study Objective: To measure the effectiveness of a multimodal strategy, including simultaneous implementation of a clinical decision support system, to sustain adherence to a clinical pathway for care of children with minor head trauma treated in general emergency departments (EDs).

Methods: Prospective, type III hybrid effectiveness-implementation cohort study with a nonrandomized stepped-wedge design and monthly repeated site measures. The study population included pediatric minor head trauma encounters from July 2018 to December 2020 at 21 urban and rural general ED sites in an integrated health care system. Read More

Rev Mal Respir 2022 Jun 22. Epub 2022 Jun 22.

Service d'anatomie-pathologique, groupement hospitalier est, HCL, Bron, France.

Background: Since the previous French guidelines were published in 2017, substantial additional knowledge about idiopathic pulmonary fibrosis has accumulated.

Methods: Under the auspices of the French-speaking Learned Society of Pulmonology and at the initiative of the coordinating reference center, practical guidelines for treatment of rare pulmonary diseases have been established. They were elaborated by groups of writers, reviewers and coordinators with the help of the OrphaLung network, as well as pulmonologists with varying practice modalities, radiologists, pathologists, a general practitioner, a head nurse, and a patients' association. Read More

J Prosthet Dent 2022 Jun 22. Epub 2022 Jun 22.

Reader, Department of Prosthodontics and Crown & Bridge, T. P. C. T.'s Terna Dental College, Navi Mumbai, India.

Statement Of Problem: Systematic reviews and meta-analyses have emerged as forerunners of evidence-based dentistry, but assessing the quality of the available research is essential so that it can be applied to clinical practice. While a wide variety of risk-of-bias tools are available, each specifically developed for different study designs, a comprehensive tool exclusively framed to assess the quality of in vitro dental studies is lacking.

Purpose: The purpose of this study was to develop and validate a tool to evaluate the quality and risk of bias of in vitro dental studies. Read More

Otolaryngol Clin North Am 2022 Jun 22. Epub 2022 Jun 22.

Center for the Care of the Professional Voice, 980 Westfall road, Suite 1-127, Rochester, NY 14618, USA. Electronic address:

The use of gender-affirming hormone therapy is found almost universally in transgendered and nonbinary patients presenting for gender-affirming surgical procedures of the face, neck, and voice. Surgeons caring for this population need to be aware of the effects, reasonable expectations, and limitations as well as potential perioperative risks of both continuation and discontinuation of hormone therapy. Read More

Otolaryngol Clin North Am 2022 Jun 22. Epub 2022 Jun 22.

Department of Otolaryngology - Head and Neck Surgery, Boston University School of Medicine, One Boston Medical Center Place, Boston, MA 02118, USA; The Spiegel Center, 335 Boylston Street, Newton, MA 02459, USA. Electronic address:

An increasing number of transgender patients are seeking gender-affirming facial surgery, also known as facial feminization surgery. Physicians offering these services must be well versed in how to compassionately care for this patient population. We recommend having a well-informed staff that is knowledgeable about proper verbiage, use of pronouns, and preferred names for transgender patients. Read More

Otolaryngol Clin North Am 2022 Jun 22. Epub 2022 Jun 22.

Consulting Editor Otolaryngologic Clinics of North America; Past President, American Academy of Otolaryngology-, Head and Neck Surgery; Secretary-Treasurer and President-Elect, American Otological Society; Eastern Section Vice President and Sections Meeting Program Chair, Triological Society; Partner, ENT & Allergy Associates LLP, 18 East 48th Street, 2nd Floor, New York, NY 10017, USA; Clinical Professor, Department of Otolaryngology- Head and Neck Surgery, Zucker School of Medicine at Hofstra-Northwell, Hempstead, NY, USA; Clinical Associate Professor, Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Co-Host and Co-Executive Producer, She's On Call. Electronic address:

Semin Nucl Med 2022 Jun 22. Epub 2022 Jun 22.

Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet Copehagen University Hospital, Copenhagen, Denmark.

PET/CT with the tracer 2-[F]fluoro-2-deoxy-D-glucose ([F]FDG) has improved diagnostic imaging in cancer and is routinely used for diagnosing, staging and treatment planning in lung cancer patients. However, pitfalls of [F]FDG-PET/CT limit the use in specific settings. Additionally, lung cancer is still the leading cause of cancer associated death and has high risk of recurrence after curative treatment. Read More

Neuroscience 2022 Jun 22. Epub 2022 Jun 22.

Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, United States. Electronic address:

Dendritic spines are small protrusions on dendrites that serve as the postsynaptic site of the majority of excitatory synapses. These structures are important for normal synaptic transmission, and alterations in their density and morphology have been documented in various disease states. Over 130 years ago, Ramón y Cajal used Golgi-stained tissue sections to study dendritic morphology. Read More

Neuroscience 2022 Jun 22. Epub 2022 Jun 22.

Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, United States. Electronic address:

Recessive mutations in GRXCR2 cause deafness in both humans and mice. In Grxcr2 null hair cells, the sensory receptors for sound in the inner ear, stereocilia are disorganized. Reducing the expression of taperin, a protein that interacts with GRXCR2 at the base of stereocilia, corrects the morphological defects of stereocilia and restores hearing in Grxcr2 null mice. Read More

Crit Rev Oncol Hematol 2022 Jun 22:103751. Epub 2022 Jun 22.

Molecular Cancer Genetics & Translational Research Lab, Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh-202002, India. Electronic address:

Background: Apigenin is being increasingly recognized as a cancer chemopreventive agent. We aimed to investigate the anticancer effects of Apigenin in in-vivo studies to know its present research status and how close or how far it is from the clinics.

Methods: Several electronic databases such as PubMed, Springer, Cochrane, and ctri. Read More

Fish Shellfish Immunol 2022 Jun 22. Epub 2022 Jun 22.

Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-resources, Institute of Tropical Bioscience and Biotechnology, Hainan Institute of Tropical Agricultural Resources, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, China. Electronic address:

This study aimed to investigate the effects of Elephantopus scaber extract on the GIFT (genetic improvement of farmed tilapia) strain of Nile tilapia Oreochromis niloticus. A total of 800 tilapia with an initial body weight of 1.34 ± 0. Read More

Am J Obstet Gynecol 2022 Jun 22. Epub 2022 Jun 22.

Departments of Obstetrics & Gynecology and Global Health, University of Washington, Seattle, Washington, United States of America.

The coronavirus disease 2019 (COVID-19) pandemic has disproportionately impacted pregnant people by increasing health risks of maternal morbidity and mortality, stillbirth, and preterm birth. Although numerous studies have supported the safety and efficacy of COVID-19 vaccination in pregnancy to prevent or mitigate risk for these adverse outcomes, many pregnant people remain hesitant. Approximately half of U. Read More

Curr Probl Cancer 2022 Jun 11;46(4):100878. Epub 2022 Jun 11.

Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Electronic address:

The significance of tumor infiltrating lymphocytes (TILs) in melanoma has been studied for a long time, but, to date, there has been insufficient research on TILs in sinonasal mucosal melanoma. The purpose of this study was to analyze the correlation between TILs and prognosis for Chinese patients with sinonasal mucosal melanoma, and to clarify the significance of TILs in prognosis. As a retrospective cohort study, 44 cases of malignant melanoma in head and neck mucosa were studied by immunohistochemical staining. Read More

Oral Oncol 2022 Jun 22;132:105955. Epub 2022 Jun 22.

Department of Head and Neck Surgery & Communication Sciences, Duke University Medical Center, Durham, NC, USA; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA. Electronic address:

Objectives: To develop and validate a prediction model to estimate overall survival (OS) with and without postoperative radiotherapy (PORT) for resected major salivary gland (SG) cancers.

Materials And Methods: Adults in the National Cancer Database diagnosed with invasive non-metastatic major SG cancer between 2004 and 2015 were identified. Exclusion criteria included prior malignancy, pT1N0 or unknown stage, no or unknown surgery, and neoadjuvant therapy. Read More

Comput Methods Programs Biomed 2022 Jun 9;222:106948. Epub 2022 Jun 9.

Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany. Electronic address:

Objectives: Recent studies have shown that deep learning based on pre-treatment positron emission tomography (PET) or computed tomography (CT) is promising for distant metastasis (DM) and overall survival (OS) prognosis in head and neck cancer (HNC). However, lesion segmentation is typically required, resulting in a predictive power susceptible to variations in primary and lymph node gross tumor volume (GTV) segmentation. This study aimed at achieving prognosis without GTV segmentation, and extending single modality prognosis to joint PET/CT to allow investigating the predictive performance of combined- compared to single-modality inputs. Read More

Epilepsy Behav 2022 Jun 22;133:108784. Epub 2022 Jun 22.

Monroe Carell Jr. Children's Hospital at Vanderbilt University Medical Center, 2200 Children's Way, Nashville, TN 37232, USA. Electronic address:

The benefits of continuous electroencephalography (cEEG) monitoring in the intensive care unit (ICU) are increasingly appreciated, though expanding indications for cEEG may strain resources. The current standard of care in babies with hypoxic-ischemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH) includes cEEG monitoring throughout the entire TH and rewarming process (at least 72 h). Recent cEEG data demonstrate that most seizures occur within the first 24 h of monitoring. Read More

J Hazard Mater 2022 Jun 13;437:129365. Epub 2022 Jun 13.

Shandong Key Laboratory of Environmental Processes and Health, School of Environmental Science and Engineering, Shandong University, Qingdao 266237, China. Electronic address:

Polycyclic aromatic hydrocarbon (PAH) pollution caused by marine oil spills and antibiotic pollution caused by aquaculture industries were common environmental problems in the Yellow River Estuary, China. But few data are reported on the bioaccumulation and influencing factors of these two types of contaminants in aquaculture simultaneously. This study investigated the occurrence and bioaccumulation of PAHs and antibiotics in aquaculture areas of the Yellow River Estuary, and explored the factors affecting the bioaccumulation. Read More

Anim Reprod Sci 2022 Jun 20;243:107029. Epub 2022 Jun 20.

Laboratory on Animal Germplasm Conservation, Universidade Federal Rural do Semi-Árido, UFERSA, Mossoró, RN, Brazil. Electronic address:

The red-rumped agouti (Dasyprocta leporina) is a hystricognath rodent with reproductive anatomical peculiarities presenting as an intra-abdominal testes-epididymis complex. This study was carried out to describe, for the first time, details related to the morphological and functional changes in sperm along the epididymal transit in agoutis. The testes-epididymal complexes were sampled from seven sexually mature agoutis. Read More