606,504 results match your criteria Head and Neck Carcinoma in the Young Patient


Survival, Motor Function, and Motor Milestones: Comparison of AVXS-101 Relative to Nusinersen for the Treatment of Infants with Spinal Muscular Atrophy Type 1.

Adv Ther 2019 Mar 16. Epub 2019 Mar 16.

AveXis, Inc., Bannockburn, IL, USA.

Introduction: Infants with spinal muscular atrophy (SMA) type 1 typically face a decline in motor function and a severely shortened life expectancy. Clinical trials for SMA type 1 therapies, onasemnogene abeparvovec (AVXS-101) and nusinersen, demonstrated meaningful improvements in efficacy (e.g. Read More

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http://dx.doi.org/10.1007/s12325-019-00923-8DOI Listing

Long-term health-related quality of life after mandibular resection and reconstruction.

Eur Arch Otorhinolaryngol 2019 Mar 16. Epub 2019 Mar 16.

The Department of Otolaryngology Head and Neck Surgery, Tel-Aviv Sourasky Medical Center (affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel), Tel-Aviv, Israel.

Purpose: To compare short- and long-term quality of life (QOL) scores in patients undergoing mandibular resection and reconstruction.

Materials And Methods: All the patients who underwent resection and reconstruction of the mandible between 2000 and 2015 at a large tertiary center were retrospectively reviewed. Their QOL was measured by the University of Washington QOL questionnaire. Read More

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http://dx.doi.org/10.1007/s00405-019-05371-2DOI Listing

Physical and psychological outcomes of simple sigmoid sinus bony wall repair for pulsatile tinnitus due to sigmoid sinus wall anomalies.

Eur Arch Otorhinolaryngol 2019 Mar 16. Epub 2019 Mar 16.

Department of Otolaryngology-Head and Neck Surgery, Eye and ENT Hospital of Fudan University, Shanghai, China.

Purpose: Pulsatile tinnitus (PT) due to sigmoid sinus wall anomalies (SSWA) is a common health disorder. The purpose of this study is to investigate the efficiency of simple sigmoid sinus bony wall repair on tinnitus relief and psychological improvement.

Methods: Nine cases of PT due to SSWA were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s00405-019-05380-1DOI Listing

The Impact of Raising the Bar for Clinical Trials in Ulcerative Colitis.

J Crohns Colitis 2019 Feb 14. Epub 2019 Feb 14.

University of Michigan, Ann Arbor, MI, USA.

In order to identify the practical implications for both health care practitioners and patients in understanding differences between the results of trials assessing therapies for ulcerative colitis [UC], we reviewed clinical trials of therapies for moderate to severe UC, with a focus on trial design. Over time, patient populations in UC trials have become more refractory, reflecting that patients are failing treatment with additional and different classes of drug, including conventional therapies, immunosuppressant drugs, and anti-tumour necrosis factor therapies. Outcomes used to measure efficacy have become increasingly stringent in order to meet the expectations of patients and physicians, and the requirements of regulatory bodies. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjz038DOI Listing
February 2019

Surgical resection of carotid-jugular arteriovenous fistula after multiple failed embolisation.

BMJ Case Rep 2019 Mar 16;12(3). Epub 2019 Mar 16.

Department of Neurosurgery, National Neuroscience Institute, Singapore, Singapore.

Carotid-jugular fistula is a rare presentation of arteriovenous fistula. A case of a 60-year-old Chinese man who presented with iatrogenic carotid-jugular fistula with multiple fistulous points was reported. His presenting complaint was a gradually enlarging right pulsatile neck mass complicated by worsening symptoms of congestive cardiac failure. Read More

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http://dx.doi.org/10.1136/bcr-2018-228232DOI Listing

Treatment of Locally Advanced Nasopharyngeal Carcinoma by Helical Tomotherapy: An Observational, Prospective Analysis.

Transl Oncol 2019 Mar 14;12(5):757-763. Epub 2019 Mar 14.

Department of Radiation Oncology, The University of Texas Southwestern Medical Center, Dallas, TX.

Nasopharyngeal carcinoma (NPC) is endemic in southern China. Due to the unique anatomical and biological properties of NPCs, radiotherapy or combined modality based on radiotherapy is an effective treatment option. Helical tomotherapy (HT) is an emerging intensity modulated radiotherapy technology. Read More

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http://dx.doi.org/10.1016/j.tranon.2019.02.011DOI Listing

3D printing of meat.

Meat Sci 2019 Mar 7;153:35-44. Epub 2019 Mar 7.

School of Agriculture and Food Sciences, The University of Queensland, St Lucia, QLD 4072, Australia. Electronic address:

Three-dimensional printing (3DP) process stands as a developing technology for food manufacturing, which offers the opportunity to design novel food products with improved nutritional value and sensorial profile. This review analyses the potential applications of 3DP technology for meat processing and the elemental aspects affecting the printability and post-processing feasibility of 3D printed meat products. The combination of nutritionally balanced ingredients and novel internal structures may be schemed into a multi-material 3D model that meets special individual needs, such as chewing and swallowing difficulties. Read More

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http://dx.doi.org/10.1016/j.meatsci.2019.03.005DOI Listing

Epigenetic changes: An emerging potential pharmacological target in allergic rhinitis.

Int Immunopharmacol 2019 Mar 14;71:76-83. Epub 2019 Mar 14.

Department of Otolaryngology-Head and Neck Surgery, The Second Hospital of Jilin University, Changchun 130041, China. Electronic address:

The importance of epigenetics has increased due to identification of its role in the pathophysiology of a number of diseases including allergic rhinitis. Amongst the different epigenetic changes in allergic retinitis, deacetylation of histone proteins by histone deacetylase (HDACs), hypermethylation of DNA by DNA methyltransferases (DNMT) and alteration in post-transcriptional process by the changes in the levels of miRNA are widely studied. Studies conducted related to allergic rhinitis have shown the elevation in the levels of HDAC1, 3 and 11 in the nasal epithelia and HDAC inhibitors have shown effectiveness in decreasing the symptoms of rhinitis. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.03.004DOI Listing

Toxic effects of oxine-copper on development and behavior in the embryo-larval stages of zebrafish.

Aquat Toxicol 2019 Feb 27;210:242-250. Epub 2019 Feb 27.

Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs, Ji'an, Jiangxi, China; Center for Developmental Biology of Jinggangshan University, College of Life Sciences, Jinggangshan University, Ji'an, Jiangxi, China. Electronic address:

Oxine-copper (OxCu) is generally used as an agricultural pesticide and induces harmful effects on ecosystems. In this study, zebrafish was used to assess the aquatic toxicity of OxCu. To detect the effects on development, embryos of 6 h post-fertilization (hpf) were exposed to 10 μg/L, 20 μg/L, 40 μg/L OxCu for 18 h; meanwhile, to evaluate the effects on the behavior, larval fish at 6 days post-fertilization (dpf) were exposed to the same concentrations for 24 h. Read More

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http://dx.doi.org/10.1016/j.aquatox.2019.02.020DOI Listing
February 2019

Cured from a Cardiac Myxoma? Brain Intraparenchymal Hemorrhage in a Patient with a 10-year Successfully Resected Cardiac Myxoma.

World Neurosurg 2019 Mar 13. Epub 2019 Mar 13.

Lyerly Neurosurgery / Baptist Neurological Institute, Jacksonville, FL. Electronic address:

Background: A cardiac myxoma (CM) is the most common primary tumor of the heart. This case report highlights that for metastatic cardiac myxomas, even after a successful total resection, there is a small but real risk of recurrence that can manifest as late as 10 years after initial tumor resection.

Case Description: We present the case of a 53-year-old woman who visited the emergency room after a 4-day worsening right-sided weakness. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.295DOI Listing

Profile of Head Injuries: Pre hospital Care, Diagnosis and Severity in an Ethiopian Tertiary Hospital.

World Neurosurg 2019 Mar 13. Epub 2019 Mar 13.

Emergency Medicine Department, Addis Ababa University, College of Health Sciences, Ethiopia.

Background: Consistent data on head injury is lacking especially in the low and middle income countries. Our study tries to characterize head injury patients at the emergency room of one of the few tertiary public hospitals giving neurosurgical care in the country.

Methods: A retrospective cross sectional study done from May 2015 -October 2015 in one of the neurosurgical teaching hospitals, Black Lion Specialized Hospital. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.044DOI Listing

Impaired EIF2S3 function associated with a novel phenotype of X-linked hypopituitarism with glucose dysregulation.

EBioMedicine 2019 Mar 13. Epub 2019 Mar 13.

Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, United Kingdom. Electronic address:

Background: The heterotrimeric GTP-binding protein eIF2 forms a ternary complex with initiator methionyl-tRNA and recruits it to the 40S ribosomal subunit for start codon selection and thereby initiates protein synthesis. Mutations in EIF2S3, encoding the eIF2γ subunit, are associated with severe intellectual disability and microcephaly, usually as part of MEHMO syndrome.

Methods: Exome sequencing of the X chromosome was performed on three related males with normal head circumferences and mild learning difficulties, hypopituitarism (GH and TSH deficiencies), and an unusual form of glucose dysregulation. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.03.013DOI Listing

Simultaneous blocking of CD47 and PD-L1 increases innate and adaptive cancer immune responses and cytokine release.

EBioMedicine 2019 Mar 14. Epub 2019 Mar 14.

Cancer Metastasis Alert and Prevention Center, College of Chemistry, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, China; Marine Drug R&D Center, Institute of Oceangraphy, Minjiang University, Fuzhou 350108, China. Electronic address:

Background: Treatment multiple tumors by immune therapy can be achieved by mobilizing both innate and adaptive immunity. The programmed death ligand 1 (PD-L1; or CD274, B7-H1) is a critical "don't find me" signal to the adaptive immune system. Equally CD47 is a critical "don't eat me" signal to the innate immune system and a regulator of the adaptive immune response. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523964193015
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http://dx.doi.org/10.1016/j.ebiom.2019.03.018DOI Listing
March 2019
3 Reads

Root Elongation After Autotransplantation in 58 Transplanted Premolars: The Radiographic Width of the Apex as a Predictor.

J Oral Maxillofac Surg 2019 Feb 20. Epub 2019 Feb 20.

Maxillofacial Surgeon, Professor, and Department Head, Department of Oral and Maxillofacial Surgery, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

Purpose: Autotransplantation of premolars with incomplete root development is a reliable treatment option for tooth replacement. Nevertheless, little is known about root development after transplantation of teeth. The aim of this study was to evaluate preoperative root development stage and radiographic width of the apex as predictors for root elongation after autotransplantation. Read More

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http://dx.doi.org/10.1016/j.joms.2019.02.019DOI Listing
February 2019

Reconstruction of the Oral Commissure With the Zisser Flap.

J Oral Maxillofac Surg 2019 Feb 19. Epub 2019 Feb 19.

Professor and Department Head, First Department of Otorhinolaryngology, Head and Neck Surgery, Aristotle University of Thessaloniki, Thessaloniki, Greece.

The aim of this study was to investigate the role of the Zisser flap in the reconstruction of defects of the oral commissure. We describe our personal experience with this method and present some interesting aspects from the relevant literature. We retrospectively evaluated the records, from the period between 2003 and 2017, of all patients with defects of the oral commissure after resection of malignant tumors, traumas, or burns and reconstruction by means of the Zisser flap. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02782391193022
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http://dx.doi.org/10.1016/j.joms.2019.02.017DOI Listing
February 2019
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Intraoperative Depth of Invasion Is Accurate in Early-Stage Oral Cavity Squamous Cell Carcinoma.

J Oral Maxillofac Surg 2019 Feb 20. Epub 2019 Feb 20.

Chair, Section of Oral and Maxillofacial Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI.

Purpose: Depth of invasion (DOI) is one predictor of nodal metastasis in oral cavity squamous cell carcinoma (OCSCC) and can facilitate the decision to complete an elective neck dissection (END) in early-stage disease with a clinically negative neck. The purpose of this study was to investigate the accuracy of DOI in intraoperative frozen specimens for T1N0 oral OCSCC.

Materials And Methods: To compare the accuracy of DOI in frozen versus permanent specimens, we completed a prospective, blinded study of 30 patients with cT1N0 OCSCC who presented between October 2016 and December 2017. Read More

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http://dx.doi.org/10.1016/j.joms.2019.02.016DOI Listing
February 2019

Successful Mandibular Mucormycosis Treatment in the Severely Neutropenic Patient.

J Oral Maxillofac Surg 2019 Feb 18. Epub 2019 Feb 18.

Head, Department of Oral and Maxillofacial Surgery, Hebrew University-Hadassah, Jerusalem, Israel.

Purpose: Mucormycosis is a rare opportunistic and aggressive deep fungal infection that predominantly affects immunocompromised patients, and its mortality rate has been reported as up to 80%. Typing of the infection is based mainly on clinical and anatomic presentations, with the most common being the rhinocerebral type.

Materials And Methods: This report presents 3 patients with cancer who had successful treatment of mandibular mucormycosis. Read More

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http://dx.doi.org/10.1016/j.joms.2019.02.012DOI Listing
February 2019

Characterizing the Effects of Radiation Dermatitis on Quality of Life: A Prospective Survey-Based Study.

J Am Acad Dermatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Medicine, Division of Dermatology, Albert Einstein College of Medicine, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2019.03.011DOI Listing

Type 1 tympanoplasty in pediatric patients: Comparison of fascia and perichondrium grafts.

Int J Pediatr Otorhinolaryngol 2019 Mar 9;121:95-98. Epub 2019 Mar 9.

Aksaray University Faculty of Medicine, Department of Ear Nose and Throat and Head and Neck Surgery, Turkey. Electronic address:

Objective: The timing of tympanoplasty in the pediatric age group is an ongoing debate. The purpose of this study was to analyze and compare the success of grafts in type 1 tympanoplasty in pediatric patients, and to evaluate the prognostic factors that may affect its success.

Materials And Methods: A retrospective study of 42 pediatric patients who were younger than 18 years and underwent a primary type 1 tympanoplasty using tragal cartilage perichondrium and temporalis fascia from January 2013 to December 2018, were evaluated. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.03.007DOI Listing

Expression of endoplasmic reticulum stress-related mRNA in otitis media with effusion.

Int J Pediatr Otorhinolaryngol 2019 Mar 9;121:109-113. Epub 2019 Mar 9.

Department of Otorhinolaryngology-Head and Neck Surgery, Kyung Hee University School of Medicine, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea; Medical Science Research Institute, Kyung Hee University Medical Center, Seoul, Republic of Korea; Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, School of Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea. Electronic address:

Objectives: The endoplasmic reticulum (ER) is an intracellular organelle involved in the synthesis and secretion of proteins. The ER stress response, which protects cells from cytotoxic proteins such as unfolded proteins, is related to several diseases including inflammation. In this study, we investigated the effect of ER stress on the pathophysiology of otitis media with effusion (OME). Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.03.006DOI Listing

Impact of head and neck cancer on partner's sociability.

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Mar 13. Epub 2019 Mar 13.

Inserm/Université de Caen U1086, cancers et préventions, 14000 Caen, France; CHU de Caen, service ORL et chirurgie cervico-faciale, 14000 Caen, France.

Introduction: "Sociability" is defined as the range of experiences linking the subject to others. This is the first study to focus specifically on the impact of head and neck cancer on the sociability of patients' partners.

Method: Data were collected via a dedicated questionnaire sent to patients' partners. Read More

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http://dx.doi.org/10.1016/j.anorl.2019.02.017DOI Listing

"Suggestive" and "Significant": You can't always get what you want….

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Mar 13. Epub 2019 Mar 13.

30, rue Faidherbe, 75011, Paris, France.

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http://dx.doi.org/10.1016/j.anorl.2019.02.006DOI Listing

Craniofacial penetration by a wooden stick.

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Mar 13. Epub 2019 Mar 13.

Dolphin west-Funabashi ENT clinic, 2-335-1 Katsushika, Funabashi-City, Chiba 273-0032, Japan.

Introduction: Penetrating craniofacial injuries caused by stick-like foreign bodies occur as a result of accidents particularly in children, and often lead to significant morbidity.

Case Summary: We describe a 5-year-old boy who sustained facial trauma after falling on a wooden stick which penetrated his left cheek. At the initial visit, his vital and neurological signs were normal. Read More

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http://dx.doi.org/10.1016/j.anorl.2018.07.008DOI Listing

Multi-electrode sequential versus single electrode stimulation to elicit the stapedial reflex during cochlear implantation: Correlation with maximum comfort level.

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Mar 13. Epub 2019 Mar 13.

Audiology Unit, Department of Clinical and Experimental Medicine, U.O.C. Otorinolaringoiatria e Otoneurochirurgia, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, 43100 Parma, Italy.

Objectives: To assess whether electrical stimulation sequentially delivered through 4 electrodes located in different cochlear areas may elicit the stapedial reflex at lower levels compared to single electrode stimulation and to correlate the sequentially obtained values with the maximum comfort level (C-level).

Patients And Methods: A retrospective study was performed on 35 post-verbal adult patients (age 19-80 years) consecutively implanted in 2 cochlear implant centers, evaluating the level of stimulation (pulse width) necessary to electrically evoke the stapedial reflex with two different stimulation modalities: single electrode versus sequential 4 electrode stimulation. Threshold values were compared with C-level obtained at activation. Read More

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http://dx.doi.org/10.1016/j.anorl.2018.01.012DOI Listing

Association of Macular and Circumpapillary Microvasculature with Visual Field Sensitivity in Advanced Glaucoma.

Am J Ophthalmol 2019 Mar 13. Epub 2019 Mar 13.

Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, and Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, United States. Electronic address:

Purpose: To evaluate the association between optical coherence tomography angiography (OCTA) macular and circumpapillary vessel density and visual field mean deviation (MD) in advanced primary open angle glaucoma (POAG).

Design: Cross-sectional study.

Methods: Macula (superficial layer) and optic nerve head [ONH, with (capillary density :CD) and without (vessel density: VD) automated removal of large vessels] OCTA of 34 eyes (34 patients, MD < -10 dB) were investigated as macula whole image VD (wiVD), parafoveal VD (pfVD), ONH wiVD, wiCD, circumpapillary VD (cpVD), and cpCD. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.004DOI Listing

Ventriculostomy and endoscopic biopsy of pineal mass with hydrocephalus and unexpected definitive diagnosis.

Neurocirugia (Astur) 2019 Mar 13. Epub 2019 Mar 13.

Servicio de Neurocirugía, Complejo Hospitalario de Jaén, Hospital Neurotraumatológico, Jaén, España.

A 72-year-old female with no relevant medical history consulted in the emergency room for a two-week history of headache, vomiting and gait disturbance. Head CT scan revealed obstructive hydrocephalus secondary to a pineal mass with compression of the third ventricle. Magnetic Resonance showed another mass located in the right Lushcka foramen. Read More

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http://dx.doi.org/10.1016/j.neucir.2019.01.005DOI Listing

Naringin regulates bone metabolism in glucocorticoid-induced osteonecrosis of the femoral head via the Akt/Bad signal cascades.

Chem Biol Interact 2019 Mar 13. Epub 2019 Mar 13.

Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, 300052, People's Republic of China. Electronic address:

Purpose: Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a common disease following long-term use or large doses of glucocorticoids. The pathogenesis of GIONFH remains controversial, and abnormal bone metabolism caused by glucocorticoids(GCs) may be one of the important factors. Due to its positive effect on bone remodeling, naringin shows potential therapeutic effects in bone metabolism-related diseases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797183140
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http://dx.doi.org/10.1016/j.cbi.2019.03.008DOI Listing
March 2019
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"The effect of tDCS on functional connectivity in primary progressive aphasia" NeuroImage: Clinical, volume 19 (2018), pages 703-715.

Neuroimage Clin 2019 Mar 13:101734. Epub 2019 Mar 13.

Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA; Department of Cognitive Science, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address:

Transcranial direct current stimulation (tDCS) is an innovative technique recently shown to improve language outcomes even in neurodegenerative conditions such as primary progressive aphasia (PPA), but the underlying brain mechanisms are not known. The present study tested whether the additional language gains with repetitive tDCS (over sham) in PPA are caused by changes in functional connectivity between the stimulated area (the left inferior frontal gyrus (IFG)) and the rest of the language network. We scanned 24 PPA participants (11 female) before and after language intervention (written naming/spelling) with a resting-state fMRI sequence and compared changes before and after three weeks of tDCS or sham coupled with language therapy. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101734DOI Listing
March 2019
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Associations between Sleep and Dietary Patterns among Low-Income Children Attending Preschool.

J Acad Nutr Diet 2019 Mar 13. Epub 2019 Mar 13.

Background: Sleep disturbances and low-quality diets are prevalent among children in low-income settings, yet the nature of their relationship remains unclear. In particular, whether aspects other than sleep duration, including timing and quality, are associated with dietary patterns has rarely been examined, especially among preschool-aged children.

Objective: To evaluate whether nightly and total sleep duration, sleep timing, differences in timing and duration from weekdays to weekends, and sleep quality were related to dietary patterns. Read More

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http://dx.doi.org/10.1016/j.jand.2019.01.008DOI Listing

Changes in Atlantic salmon (Salmo salar) sperm morphology and membrane lipid composition related to cold storage and cryopreservation.

Anim Reprod Sci 2019 Mar 5. Epub 2019 Mar 5.

Department of Chemical Engineering, Faculty of Engineering and Science, University of La Frontera, Temuco, Chile; Center of Reproductive Biotechnology - Scientific and Technological Bioresource Nucleus (CEBIOR - BIOREN), University of La Frontera, Temuco, Chile. Electronic address:

The cold storage and cryopreservation of semen decrease sperm quality. Morphological and biochemical analyses of spermatozoa provide valuable information for the optimization of storage protocols to obtain a sufficient number of spermatozoa for in vitro fertilization. The aim of this study was to evaluate the morphology and lipid composition of Atlantic salmon (Salmo salar) spermatozoa after storage at 4 °C and cryopreservation. Read More

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http://dx.doi.org/10.1016/j.anireprosci.2019.03.004DOI Listing

Image-Guided Percutaneous Gastrostomy Tube Placement is Safe in Patients Requiring Aspirin 325 mg.

Acad Radiol 2019 Mar 14. Epub 2019 Mar 14.

Department of Radiology, Duke University School of Medicine, Durham, North Carolina.

Rationale And Objectives: Requests for gastrostomy tube placement in patients on aspirin (ASA) 325 mg are common, particularly in patients following reconstructive surgery for head and neck cancer, but periprocedural guidelines and recommendations regarding management of high dose aspirin are inconsistent. The purpose of this study was to assess the bleeding risk of percutaneous gastrostomy tube placement in patients on ASA 325 mg.

Materials And Methods: This retrospective study of 213 patients who underwent image-guided "push" percutaneous gastrostomy tube placement compared rates of significant bleeding and other secondary outcomes (including all-cause mortality within 30 days, procedure-related mortality, bowel perforation, abdominal abscess, peritonitis, aspiration pneumonia, intraprocedural airway complications, and tube dislodgement) between patients maintained on ASA 325 mg and patients not on antiplatelet or anticoagulation therapy. Read More

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http://dx.doi.org/10.1016/j.acra.2019.02.008DOI Listing

Vibroplasty combined with tympanic membrane reconstruction in middle ear ventilation disorders.

Hear Res 2019 Feb 27. Epub 2019 Feb 27.

Technische Universitaet Dresden, Faculty of Medicine Carl Gustav Carus, Department of Otorhinolaryngology, Ear Research Center, Dresden, Germany.

Although the Vibrant Soundbridge is one of the most frequently used active middle ear implants, data regarding how middle ear ventilation disorders may affect the transmission behavior of its floating mass transducer are still insufficient. Studies involving coupling the floating mass transducer to the stapes head are particularly lacking. This temporal bone study evaluated the influence of simulated middle ear ventilation disorders on the middle ear transfer function in the reconstructed middle ear. Read More

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http://dx.doi.org/10.1016/j.heares.2019.02.012DOI Listing
February 2019

Deltoid-split approach versus deltopectoral approach for proximal humerus fractures: A systematic review and meta-analysis.

Orthop Traumatol Surg Res 2019 Mar 13. Epub 2019 Mar 13.

Department of Orthopaedics Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, XueYuan West road, 325000 Wenzhou, Luheng District, Zhejiang Province, People's Republic of China. Electronic address:

Purpose: To investigate the evidence of deltoid-split approach (DS) versus deltopectoral approach (DP) in treatment of proximal humerus fractures from current RCT and prospective literatures.

Methods: The electronic literature database of Pubmed, Embase, and Cochrane library was searched at December 2017. The data complications (including implant failure, humeral head necrosis, infection, radiological adverse events, nonunion rate, subacromial impingement, and damage of the axillary nerve), functional outcomes (including Constant, NEER, DASH, ADL, VAS score), operation time, hospital stay and intraoperative blood loss were extracted and analyzed by STATA 11. Read More

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http://dx.doi.org/10.1016/j.otsr.2018.12.004DOI Listing

[Diagnostic and treatment pitfalls and guidelines for variants of squamous cell carcinomas of the head and neck].

Bull Cancer 2019 Mar 13. Epub 2019 Mar 13.

Hôpital Bichat, département d'oto-rhino-laryngologie (ORL) et chirurgie cervico-faciale, 46 rue Henri-Huchard, 75018 Paris, France.

Among the 20,000 new cases of head and neck neoplasms in France each year, squamous cell carcinomas (HNSCC) represent about 90 % of the cases. Among these, variants of conventional squamous cell carcinomas represent between 5% and 10% of cases. Patient history and risk factors are often similar from those of conventional HSNCC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00074551193011
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http://dx.doi.org/10.1016/j.bulcan.2019.01.015DOI Listing
March 2019
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Knee Dislocation (KD) IV Injuries of the Knee: Presentation, Treatment, and Outcomes.

Clin Sports Med 2019 Apr 19;38(2):247-260. Epub 2019 Jan 19.

Department of Orthopaedic Surgery, University of New Mexico, MSC10 5600, 1 University of New Mexico, Albuquerque, NM 87131-0001, USA. Electronic address:

"KDIV ligamentous injuries of the knee are frequently high-energy injuries with significant soft tissue disruption, gross knee instability, and rarely are treated nonoperatively. KDIVs frequently require external fixation, but when presenting in an isolated fashion can be reconstructed in one setting. Five presentations of KDIV injury are described: closed with multitrauma/closed head injury requiring external fixation, irreducible KDIV requiring semi-emergent open reduction and repair, isolated KDIV without arterial injury undergoing 4-ligament reconstruction after regaining motion, KDIV with varus and slight thrust undergoing medial opening osteotomy before ligament reconstruction, and KDIV with failed ligaments requiring revision and posterior tibial tendon transfer. Read More

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http://dx.doi.org/10.1016/j.csm.2018.11.007DOI Listing

Multiple Ligament Injured Knee: Initial Assessment and Treatment.

Clin Sports Med 2019 Apr 19;38(2):193-198. Epub 2019 Jan 19.

Geisinger Orthopaedics, 115 Woodbine Lane, Danville, PA 17822-5212, USA. Electronic address:

The multiple ligament injured knee (knee dislocation) is oftentimes part of a multisystem injury complex that can include injuries not only to knee ligaments but also to blood vessels, skin, nerves, bones (fractures), head, and other organ system trauma. These additional injuries can affect surgical timing for knee ligament reconstruction and also affect the results of treatment. This article presents the author's approach and experience to the initial assessment and treatment of the multiple ligament injured (dislocated) knee. Read More

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http://dx.doi.org/10.1016/j.csm.2018.11.004DOI Listing

Network meta-analysis of randomised trials of pharmacological, psychotherapeutic, exercise and collaborative care interventions for depressive symptoms in patients with coronary artery disease: hybrid systematic review of systematic reviews protocol.

Syst Rev 2019 Mar 16;8(1):71. Epub 2019 Mar 16.

Queen's University Belfast, Belfast, UK.

Background: Depression is common in patients with coronary artery disease (CAD) and is associated with poorer outcomes and higher costs. Several randomised controlled trials (RCTs) targeting depression, of various modalities (including pharmacological, psychotherapeutic and other approaches), have been conducted and summarised in pairwise meta-analytic reviews. However, no study has considered the cumulative evidence within a network, which can provide valuable indirect comparisons and information about the relative efficacy of interventions. Read More

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http://dx.doi.org/10.1186/s13643-019-0985-9DOI Listing

Removal of intraconal bullet through endoscopic transnasal surgery with image-guided navigation system 8 months after injury: a case report.

J Med Case Rep 2019 Mar 17;13(1):65. Epub 2019 Mar 17.

Division of Allergy and Rhinology, Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkla, 90110, Thailand.

Background: Lodgment of a bullet within the orbit is uncommon. The decision to remove these objects poses a challenge to surgeons due to a high risk of complications. Currently, endoscopic transnasal surgery with navigator assistance facilitates the localization of foreign bodies allowing their safe removal with minimal surrounding tissue damage or optic nerve injury. Read More

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http://dx.doi.org/10.1186/s13256-019-2007-xDOI Listing

Audiological evaluation of infants using mother's voice.

Int J Pediatr Otorhinolaryngol 2019 Mar 11;121:81-87. Epub 2019 Mar 11.

Department of Otolaryngology - Head & Neck Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

Objectives: Hearing loss is a serious problem in infants and children because it may interfere with the development of typical speech, verbal language, and auditory and communication skills. By measuring hearing ability (thresholds) as early as possible, even as early as during infancy, effective treatment can be administered. These treatments may significantly reduce the handicap associated with hearing loss. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.03.005DOI Listing

Which graft should be used for the pediatric transcanal endoscopic type 1 tympanoplasty? A comparative clinical study.

Int J Pediatr Otorhinolaryngol 2019 Mar 1;121:76-80. Epub 2019 Mar 1.

Private Sanmed Hospital, Department of Otorhinolaryngology, Head and Neck Surgery, Şanlıurfa, Turkey. Electronic address:

Objectives: To compare the functional and anatomical success rates of the fascial versus perichondrial grafts in pediatric endoscopic type 1 tympanoplasties.

Methods: This retrospective clinical study was conducted on 40 pediatric patients (23 females and 17 males; mean age: 10.0 ± 1. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.02.046DOI Listing

Using intraoperative optical coherence tomography to image pediatric unilateral vocal fold paralysis.

Int J Pediatr Otorhinolaryngol 2019 Feb 26;121:72-75. Epub 2019 Feb 26.

Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.

Objectives: Unilateral vocal fold paralysis (UVFP) impairs communication and reduces academic performance and social interactions in children. Deciding between temporary, permanent, or potentially destructive surgical interventions can be challenging, as there currently exists no reliable means of predicting vocal fold recovery or assessing the presence of vocal fold atrophy. Regarding vocal fold atrophy, optical coherence tomography (OCT) has been shown to be an appealing non-invasive alternative for accessing vocal fold structures. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876193010
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http://dx.doi.org/10.1016/j.ijporl.2019.02.039DOI Listing
February 2019
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Contraception, Venous Thromboembolism, and Inflammatory Bowel Disease: What Clinicians (and Patients) Should Know.

Inflamm Bowel Dis 2019 Mar 16. Epub 2019 Mar 16.

Section of Gastroenterology, Boston Medical Center, Boston, Massachusetts.

The peak incidence of the inflammatory bowel diseases (IBDs) is between the second and fourth decades of life, which coincides with prime reproductive years. Unplanned or mistimed pregnancies may account for nearly half of all pregnancies and are associated with adverse consequences such as a higher risk of delayed preconceptual care, increased risk of preterm birth, low birth weight, and adverse maternal and neonatal outcomes. Increased IBD activity during pregnancy is also associated with adverse pregnancy-related outcomes, such as miscarriage, intrauterine growth retardation, and preterm birth. Read More

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http://dx.doi.org/10.1093/ibd/izz025DOI Listing

Avoiding the Unhappy Patient by Building Rapport in the Internet Age.

Facial Plast Surg 2019 Mar 15. Epub 2019 Mar 15.

Department of Otorhinolaryngology - Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

The dynamics of the doctor-patient relationship has been complicated as more patients seem to expect perfection in this age of selfies and Internet postings. The preoperative patient interview is critical to recognize both body language clues and subtle but apparent red flags to avoid rhinoplasty on potentially unhappy patients. This interview should include routine use of a body dysmorphic disorder screening questionnaire since legions of these patients are undiagnosed prior to surgery and few, if any, are ever satisfied with even an excellent surgical result. Read More

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http://dx.doi.org/10.1055/s-0039-1683858DOI Listing

A novel image-based retrieval system for characterization of maxillofacial lesions in cone beam CT images.

Int J Comput Assist Radiol Surg 2019 Mar 14. Epub 2019 Mar 14.

Graduate School of Information Science, Nara Institute of Science and Technology (NAIST), 8916-5, Takayama, Ikoma, Nara, 630-0192, Japan.

Purpose: The objective of medical content-based image retrieval (CBIR) is to assist clinicians in decision making by retrieving the most similar cases to a given query image from a large database. Herein, a new method for content-based image retrieval of cone beam CT (CBCT) scans is presented.

Methods: The introduced framework consists of two main phases: training database construction and querying. Read More

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http://dx.doi.org/10.1007/s11548-019-01946-wDOI Listing

Body changes after cancer: female cancer patients' perceived social support and their perspective on care.

Support Care Cancer 2019 Mar 15. Epub 2019 Mar 15.

Department of Clinical, Neuro- and Developmental Psychology, Faculty of Behavioral and Movement Sciences, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, van der Boechorststraat 7, Amsterdam, Netherlands.

Purpose: The aim of this study was to investigate among female cancer patients their perceived social support from health care professionals (HCPs), family and friends, and public media, and their perspective on care concerning body changes.

Methods: A study-specific questionnaire was completed by 235 female cancer patients. Descriptive statistics were used to describe social support and perspective on care. Read More

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http://dx.doi.org/10.1007/s00520-019-04729-wDOI Listing

Where is your head? Perception of relative position of the head on a wielded object.

Atten Percept Psychophys 2019 Mar 14. Epub 2019 Mar 14.

Department of Health Promotion Sciences, Tokyo Metropolitan University, Tokyo, Japan.

Perception of exteroceptive properties (e.g., object length) by effortful or dynamic touch is both task-specific and anatomically independent. Read More

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http://dx.doi.org/10.3758/s13414-019-01705-8DOI Listing

The clinical application of mental nerve dissection in transoral endoscopic thyroidectomy via an oral vestibular approach.

Surg Endosc 2019 Mar 14. Epub 2019 Mar 14.

The Department of Head and Neck Surgery, Hunan Cancer Hospital, The Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha, Hunan, China.

Background: Transoral endoscopic thyroidectomy vestibular approach is the natural orifice surgery to avoid surgical scars. However, mental nerve injury is a characteristic complication. Herein, we report the development of a novel method to dissect the mental nerve proactively during surgery to minimize the morbidity from mental nerve injury. Read More

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http://dx.doi.org/10.1007/s00464-019-06743-9DOI Listing

Bruner and Beyond: a Commentary.

Integr Psychol Behav Sci 2019 Mar 15. Epub 2019 Mar 15.

Department of Human Development and Childhood Studies, Lady Irwin College, University of Delhi, New Delhi, India.

The philosophy of Bruner transcends traditional boundaries in the study of the human mind with a new kind of psychology, one that frees the thinking mind from its opposition to feelings and also from the limitations of being considered an 'inside-the-head' phenomenon. It is with active engagement with the outside world that a child develops its understanding. In this engagement with the outside world, the developmental construction of thought is actively created through the use of symbols. Read More

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http://dx.doi.org/10.1007/s12124-019-09486-3DOI Listing

Investigation of anisotropic fishing line-based phantom as tool in quality control of diffusion tensor imaging.

Radiol Phys Technol 2019 Mar 16. Epub 2019 Mar 16.

Neurophysics Group, Gleb Wataghin Physics Institute, University of Campinas (UNICAMP), 777 Sergio Buarque de Holanda St, University City, Campinas, SP, 13083 859, Brazil.

This work proposes a low-cost, fishing line-based phantom for quality control of diffusion tensor imaging (DTI). The device was applied to investigate the relationship between DTI indexes (DTIi) and imaging acquisition parameters. A Dyneema fishing line phantom was built with fiber bundles of different thicknesses. Read More

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http://dx.doi.org/10.1007/s12194-019-00507-9DOI Listing

Circulating microRNAs in head and neck cancer: a scoping review of methods.

Clin Exp Metastasis 2019 Mar 14. Epub 2019 Mar 14.

Discipline of Surgery, College of Medicine and Public Health, Flinders University, Bedford Park, Australia.

Circulating microRNAs have been described as head and neck cancer biomarkers in multiple anatomical subsites including the oral cavity, nasopharynx, larynx, salivary glands and the skin. While there is an expanding volume of published literature showing the significance of individual or panels of microRNAs, the clinical validation of candidate biomarkers is lacking. The various methods used to collect, store, process and interpret these microRNAs are likely introducing bias and contributing to the inconsistent results. Read More

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http://dx.doi.org/10.1007/s10585-019-09961-6DOI Listing
March 2019
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