597,193 results match your criteria Head and Neck Carcinoma in the Young Patient
Pharmacopsychiatry 2018 Dec 6. Epub 2018 Dec 6.
Head of Department, Professor of Psychiatry and Psychotherapy, Danuvius Klinik GmbH, Pfaffenhofen an der Ilm, Technischen Universität München, Bavaria, Germany.
The combination of tiapride (TIA) and carbamazepine (CBZ) as an alternative treatment option to benzodiazepines and clomethiazole has been investigated by several investigations. We performed a systematic review and meta-analysis to further explore the efficacy of this combination in order to render more definite answers whether this combination can be recommendable in the clinical practice. We systematically searched electronic databases including PubMed (MEDLINE), EMBASE, OVID, Cochrane, Google Scholar, and Scopus for human studies. Read More
Fish Shellfish Immunol 2018 Dec 3. Epub 2018 Dec 3.
State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan University, PR China.
CC chemokines are a large subfamily of chemokines that play an important role in the innate immune system. To date, several CC chemokines have been identified in fish species; however, the activities and functions of these putative chemokines remain ambiguous in teleosts, especially in the golden pompano, Trachinotus ovatus. Here, we characterized CC chemokine ligand 4 from T. Read More
J Biomed Inform 2018 Dec 3. Epub 2018 Dec 3.
Department of Computer Science Sapienza University of Rome, Via Salaria 113, 00198, Rome, Italy. Electronic address:
Strokes, surgeries, or degenerative diseases can impair motor abilities and balance. Long-term rehabilitation is often the only way to recover, as completely as possible, these lost skills. To be effective, this type of rehabilitation should follow three main rules. Read More
Arch Phys Med Rehabil 2018 Dec 3. Epub 2018 Dec 3.
Professorand Head, Department of Orthopaedics, Smt. Kashibai Navale Medical College and General Hospintal, Pune, Maharashatra, India.
Objectives: To evaluate the effect of spinal mobilization with leg movement (SMWLM) on low back and leg pain intensity, disability, pain centralization and patient satisfaction in subjects with lumbar radiculopathy.
Design: A double blind randomized controlled trial.
Setting: General Hospital PARTICIPANTS: Sixty adults (mean age 44 years) with sub-acute lumbar radiculopathy INTERVENTIONS: Subjects were randomly allocated to receive SMWLM, exercise and electrotherapy (n = 30) or exercise and electrotherapy alone (n = 30). Read More
Acta Ortop Mex 2018 May-Jun;32(3):118-125
Instituto de Astronomía de la Universidad Nacional Autónoma de México.
Introduction: Quadrilateral plate fractures are the most difficult to reduce and fix. Different techniques have been developed for quadrilateral plate osteosynthesis. The objective of this work was to create an implant and a novel approach to simplify and improve acetabular fracture osteosynthesis. Read More
ChemMedChem 2018 Dec 6. Epub 2018 Dec 6.
SWITZERLAND.
Bruton's tyrosine kinase (Btk) is an attractive target for the treatment of a wide array of B-cell malignancies and autoimmune diseases. Small molecule covalent irreversible Btk inhibitors targeting Cys481 have been developed for the treatment of the aforementioned diseases. In clinical trials, probe molecules are required in occupancy studies to measure the level of engagement of the Btk protein by these Btk covalent irreversible inhibitors. Read More
Head Neck 2018 Dec 6. Epub 2018 Dec 6.
Otolaryngology Department, Hospital Clínic, Barcelona, Spain.
Background: Indications of transoral laser microsurgery (TLM) are conditioned by the risk of local relapse.
Objective: To evaluate prognostic factors of local relapse and local control with TLM (LC-TLM).
Methods: Local relapse and LC-TLM were evaluated in 1119 patients. Read More
Head Neck 2018 Dec 6. Epub 2018 Dec 6.
Division of Head and Neck Oncologic and Endocrine Surgery, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, California.
Background: This study examines the effect of insurance status (as a measure of socioeconomic status) on patient with benign thyroid disease.
Methods: A retrospective review was performed among 60 patients undergoing total thyroidectomy for benign thyroid disease. Univariate and multivariable analyses examined the relationship between insurance status and thyroid volume (sum of the left and right lobe volumes). Read More
Head Neck 2018 Dec 6. Epub 2018 Dec 6.
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Background: The aim of this study was to evaluate the feasibility, safety, and early surgical outcomes of transoral thyroidectomy and to compare robotic and endoscopic procedures.
Methods: A total of 37 patients underwent robotic (23 cases) or endoscopic (14 cases) transoral thyroidectomy. We compared the outcomes of the two procedures. Read More
PLoS One 2018 6;13(12):e0208729. Epub 2018 Dec 6.
Research Centre for Generational Health and Ageing, Faculty of Health and Medicine, University of Newcastle, Newcastle, NSW, Australia.
Background: In Ethiopia, the uptake of antenatal care services has been low. Moreover, there is less frequent and late attendance of antenatal care among women who attend. Using the Anderson-Newman model of health care utilization, this study identified factors that either facilitate or impede antenatal care utilization in Kersa district, Eastern Ethiopia. Read More
PLoS One 2018 6;13(12):e0208127. Epub 2018 Dec 6.
Queen Margaret University, Centre of Health, Activity and Rehabilitation Research, Edinburgh, United Kingdom.
Background: Stage 5 chronic kidney disease patients on haemodialysis (HD) often present with dizziness and pre-syncopal events as a result of the combined effect of HD therapy and cardiovascular disease. The dysregulation of blood pressure (BP) during orthostasis may be implicated in the aetiology of falls in these patients. Therefore, we explored the relationship between baroreflex function, the haemodynamic responses to a passive orthostatic challenge, and falls in HD patients. Read More
J Clin Invest 2018 Dec 6. Epub 2018 Dec 6.
Both natural influenza infection and current seasonal influenza vaccines primarily induce neutralising antibody responses against highly diverse epitopes within the "head" of the viral hemagglutinin (HA) protein. There is increasing interest on redirecting immunity towards the more conserved HA-stem or stalk as a means to broaden protective antibody responses. Here we examined HA-stem-specific B cell and T-follicular helper (Tfh) cell responses in the context of influenza infection and immunisation in mouse and monkey models. Read More
Biol Chem 2018 Dec 1. Epub 2018 Dec 1.
Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, 64295 Darmstadt, Germany.
HDAC8 is an established and validated target for T-cell lymphoma and childhood neuroblastoma. The active site binding pocket of HDAC8 is highly conserved among all zinccontaining representatives of the histone deacetylase family. This explains that most HDACs are unselectively recognized by similar inhibitors featuring a zinc binding group (ZBG), a hydrophobic linker and a head group. Read More
J Appl Physiol (1985) 2018 Dec 6. Epub 2018 Dec 6.
Neuroscience Research Australia and The University of New South Wales, Sydney, Australia.
Briefly occluding the airway during inspiration produces a short-latency reflex inhibition in human inspiratory muscles. This occlusion reflex seems specific to respiratory muscles; however, it is not known whether the reflex inhibition has a uniform effect across a motoneurone pool when a muscle is recruited concurrently for breathing and posture. In this study, participants were seated and breathed through a mouthpiece that occluded inspiratory airflow for 250 ms at a volume threshold of 0. Read More
J Phys Chem B 2018 Dec 6. Epub 2018 Dec 6.
Periodic, nanostructured porous polymer membranes made from the cross-linked inverted hexagonal phase of self-assembled lyotropic liquid crystals (LLCs) are a promising class of materials for selective separations. In this work, we investigate an experimentally characterized LLC polymer membrane using atomistic molecular modeling. In particular, we compare simulated X-ray diffraction (XRD) patterns with experimental XRD data to quantify and understand the differences between simulation and experiment. Read More
Dermatol Ther 2018 Dec 6:e12799. Epub 2018 Dec 6.
Department of Dermatology, San Jacopo Hospital, V. Ciliegiole 1, 51100 Pistoia, Italy.
Head Neck 2018 Dec 6. Epub 2018 Dec 6.
Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Background: The prognostic value of the first posttreatment whole body integrated positron emission tomography-computed tomography (PET/CT) scanning in patients with sinonasal/skull base malignancies is undetermined.
Methods: We retrospectively reviewed the data of all patients that underwent surgery for sinonasal/skull base malignancies in 2000-2015. The results of the pretreatment and posttreatment PET/CT findings and the clinical course were retrieved. Read More
Head Neck 2018 Dec 6. Epub 2018 Dec 6.
Department of Radiation Oncology, Johann Wolfgang Goethe University, Frankfurt, Germany.
Background: For locally recurrent head and neck cancer, re-irradiation with modern techniques like stereotactic body radiotherapy is a promising, possibly curative alternative to palliative systemic therapy.
Methods: We report on 1 patient with nasopharyngeal carcinoma (NPC) and 1 patient with cutaneous squamous cell carcinoma (SCC). Both patients received full dose primary treatment (>66 Gy, EQD2), full dose re-irradiation (>50 Gy, EQD2), and a second course of re-irradiation via robotic radiosurgery (CyberKnife) for a second local recurrence. Read More
Cancer 2018 Dec 6. Epub 2018 Dec 6.
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Background: The purpose of this study was to evaluate the influence of sex and race/ethnicity upon prevalence trends of human papillomavirus (HPV) in oropharyngeal cancer (OPC) and survival after OPC.
Method: This was a cohort study of patients included in the United States National Cancer Database who had been diagnosed with OPC between 2010 and 2015. Outcomes were HPV status of tumor specimens and overall survival. Read More
Cancer 2018 Dec 6. Epub 2018 Dec 6.
Department of Radiation Oncology, Baylor College of Medicine, Houston, Texas.
Background: Patients with head and neck cancer (HNC) experience significant physical and psychological morbidity during radiotherapy (RT) that contributes to treatment interruptions and a poor quality of life. Although spouses/partners can help by encouraging patient self-management (eg, self-care) during RT, they often experience high psychological distress rates, lack basic health care knowledge and skills, and report increased marital conflict regarding patient self-management. The current pilot study examined the feasibility and acceptability of a 6-session telephone-based intervention called Spouses coping with the Head And neck Radiation Experience (SHARE), which teaches self-management, communication, and coping skills to patients with HNC and their spouses. Read More
JAMA Otolaryngol Head Neck Surg 2018 Dec 6. Epub 2018 Dec 6.
Department of Otolaryngology-Head and Neck Surgery, University of Minnesota, Minneapolis.
Rheumatology (Oxford) 2018 Dec 6. Epub 2018 Dec 6.
Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Objectives: Idiopathic osteonecrosis of the femoral head (ION) is a common complication of SLE associated with CS therapy. Although the pathogenesis of ION involves local bone ischaemia favoured by thrombophilia, the involvement of aPL in lupus ION remains to be elucidated. We have previously reported the aPL score (aPL-S) as a quantitative marker of aPL and the development of thrombotic events in autoimmune diseases. Read More
JAMA Otolaryngol Head Neck Surg 2018 Dec 6. Epub 2018 Dec 6.
ENT Institute, Otorhinolaryngology Department, Eye and ENT Hospital of Fudan University, Shanghai, China.
JAMA Otolaryngol Head Neck Surg 2018 Dec 6. Epub 2018 Dec 6.
Oklahoma State University Center for Health Sciences, Tulsa.
JAMA Otolaryngol Head Neck Surg 2018 Dec 6. Epub 2018 Dec 6.
Department of Psychiatry, New York State Psychiatric Institute, Vagelos College of Physicians and Surgeons, NewYork-Presbyterian/Columbia University Irving Medical Center, Columbia University, New York.
Importance: Age-related hearing loss is highly prevalent and has recently been associated with numerous morbid conditions of aging. Late-life depression is also prevalent and can be resistant to available treatments. Preliminary studies examining the association between hearing loss and late-life depression have been limited by subjective hearing measures, small sample sizes, and primarily white populations. Read More
JAMA Otolaryngol Head Neck Surg 2018 Dec 6. Epub 2018 Dec 6.
Department of Otolaryngology, Far Eastern Memorial Hospital, Taipei, Taiwan.
JAMA Otolaryngol Head Neck Surg 2018 Dec 6. Epub 2018 Dec 6.
Institute for Health and Equity (Bioethics and Medical Humanities), Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin.
Appl Immunohistochem Mol Morphol 2018 Dec 4. Epub 2018 Dec 4.
Department of Clinical Specialistic and Dental Sciences.
The present study investigated the immunohistochemical expression of p53, p63, and p73 in different types of odontogenic cysts (OC), a group of common intraosseous jaw lesions, to provide a better understanding of p53-family functions in odontogenic lesions. We carried out immunohistochemical analysis to evaluate the expression of p53, p63, and p73 in 60 samples of OC, including dentigerous cysts, radicular cysts, orthokeratinized OC, and odontogenic keratocysts (OKC). The epithelial expression of p53-family members was evaluated both in the basal-parabasal and in the superficial layers, measuring the percentage of positive cells and the value of expression intensity. Read More
Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.
Department of Pathology, Stanford University School of Medicine, Stanford, CA.
The spectrum of tumors arising in the salivary glands is wide and has recently been shown to harbor a network of tumor-specific fusion genes. Acinic cell carcinoma (AciCC) is one of the more frequently encountered types of salivary gland carcinoma, but it has remained a genetic orphan until recently when a fusion between the HTN3 and MSANTD3 genes was described in one case. Neither of these 2 genes is known to be implicated in any other malignancy. Read More
Eur J Anaesthesiol 2019 Jan;36(1):77-78
From the Department of Anaesthesiology (KCR, NHS) and Centre for Head and Orthopaedic Surgery (TP), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
J Pediatr Hematol Oncol 2018 Dec 4. Epub 2018 Dec 4.
Departments of Otolaryngology-Head and Neck Surgery.
This study sought to examine if modern medical evaluations including newborn screening and early diagnosis along with better methods of disease control have improved rates of hearing loss in children with sickle cell disease (SCD). Audiometric and medical data for patients with SCD was obtained from the AudGen Database and analyzed for the presence of hearing loss, type of hearing loss, severity of hearing loss, and correlation with comorbid conditions. Children with sickle cell trait (SCT) were used as a comparison group. Read More
Br J Psychiatry 2018 Dec 6:1-9. Epub 2018 Dec 6.
Clinical Senior Lecturer in Mood Disorders and Consultant Psychiatrist,National Affective Disorders Service; Academic Psychiatry Training Programme Lead,Institute of Psychiatry,Psychology and Neuroscience,King's College London,South London and Maudsley NHS Foundation Trust (SLaM); andCRN South London Lead for Mental Health,Centre for Affective Disorders, Institute of Psychiatry,Psychology and Neuroscience,King's College London,South London and Maudsley NHS Foundation Trust (SLaM),UK.
Background: Most people with bipolar disorder spend a significant percentage of their lifetime experiencing either subsyndromal depressive symptoms or major depressive episodes, which contribute greatly to the high levels of disability and mortality associated with the disorder. Despite the importance of bipolar depression, there are only a small number of recognised treatment options available. Consecutive treatment failures can quickly exhaust these options leading to treatment-resistant bipolar depression (TRBD). Read More
J Neurotrauma 2018 Dec 6. Epub 2018 Dec 6.
University of Pittsburgh, Neurosurgery , 3434 Fifth Ave , Pittsburgh, Pennsylvania, United States , PA ;
New neuroprotective therapies for severe traumatic brain injury (TBI) have not translated from pre-clinical to clinical success. Numerous explanations have been suggested in both the pre-clinical and clinical arenas. Coverage of TBI in the lay press has reinvigorated interest creating a golden age of TBI research with innovative strategies to circumvent roadblocks. Read More
Saudi Med J 2018 Dec;39(12):1238-1241
Department of Otolaryngology-Head and Neck Surgery, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail.
Objectives: To determine the mean nasal skin thickness in the Middle Eastern population and to assess the effect of skin thickness on patients' satisfaction following rhinoplasty surgeries. Methods: Radiological measurements of skin thickness at the 3 vertical thirds of the nasal dorsum were taken. A total of 154 patients (80 females and 74 males) who were scheduled for computed tomography scan for the paranasal sinuses were included in the study. Read More
Soft Matter 2018 Dec 6. Epub 2018 Dec 6.
Department of Materials and Environmental Chemistry, Stockholm Universtity, Stockholm, Sweden.
Cholesterol is an essential component of all animal cell membranes and plays an important role in maintaining the membrane structure and physical-chemical properties necessary for correct cell functioning. The presence of cholesterol is believed to be responsible for domain formation (lipid rafts) due to different interactions of cholesterol with saturated and unsaturated lipids. In order to get detailed atomistic insight into the behaviour of cholesterol in bilayers composed of lipids with varying degrees of unsaturation, we have carried out a series of molecular dynamics simulations of saturated and polyunsaturated lipid bilayers with different contents of cholesterol, as well as well-tempered metadynamics simulations with a single cholesterol molecule in these bilayers. Read More
Med Sci Monit 2018 Dec 6;24:8822-8830. Epub 2018 Dec 6.
Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi, China (mainland).
BACKGROUND Astrocytomas are the most common primary brain neoplasms. Biological indicators of astrocytomas can reflect its biological characteristics. The aim of this study was to assess the expression of the pathological glial fibrillary acidic protein (GFAP) Topo IIα and O⁶-methylguanine-DNA methyltransferase (MGMT) in astrocytomas using magnetic resonance (MR) diffusion kurtosis imaging (DKI) to evaluate the biological characteristics of astrocytomas. Read More
Psychol Med 2018 Dec 6:1-9. Epub 2018 Dec 6.
School of Traditional Chinese Medicine, Southern Medical University,Guangzhou,China.
Background: We hypothesize that the tumor necrosis factor-α (TNF-α) may play a role in disturbing the effect of selective serotonin reuptake inhibitor (SSRI) on the striatal connectivity in patients with major depressive disorder (MDD).
Methods: We performed a longitudinal observation by combining resting-state functional magnetic resonance imaging (rs-fMRI) and biochemical analyses to identify the abnormal striatal connectivity in MDD patients, and to evaluate the effect of TNF-α level on these abnormal connectivities during SSRI treatment. Eighty-five rs-fMRI scans were collected from 25 MDD patients and 35 healthy controls, and the scans were repeated for all the patients before and after a 6-week SSRI treatment. Read More
Curr Aging Sci 2018 Dec 5. Epub 2018 Dec 5.
Acute Geriatrics Unit, Monza (MB). Italy.
Introduction: Doege-Potter syndrome (DPS) is a rare but life-threatening paraneoplastic syndrome, characterized by non-islet cell tumor-induced hypoglycemia (NICTH) secondary to a solitary fibrous tumor (SFT), which secretes an incompletely processed form of insulin-like growth factor 2 (IGF-2).
Results: A 96-year-old woman was admitted with head trauma due to an accidental fall. During her hospital stay she experienced frequent hypoglycemic episodes. Read More
Ther Apher Dial 2018 Dec 6. Epub 2018 Dec 6.
Department of Anaesthesiology, University of Healthy Sciences, Bakırkoy Dr. Sadi Konuk Training and Research Hospital Istanbul, Turkey.
Scoring systems are used for mortality and morbidity rating in intensive care conditions, prognosis prediction, standardization of scientific data and the monitoring of clinical quality. The aim of this study was to retrospectively analyze the efficacy of APACHE II (Acute Physiology and Chronic Health Evaluation), APACHE IV and SAPS (Simplified Acute Physiology Score) III prognostic scorings in the prediction of mortality and disease severity of patients admitted to the Anesthesia and Reanimation Clinic Intensive Care Unit (ICU) in Bakırköy Dr. Sadi Konuk Training and Research Hospital according to general and specific diagnoses. Read More
J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.
Comprehensive Center for Inflammation Medicine, University of Luebeck, Luebeck, Germany.
Background: Itch is common in psoriasis, adversely affecting health-related quality of life (HRQoL) and sleep.
Objective: We evaluated the efficacy of topical fixed-dose combination calcipotriol 50 μg/g plus betamethasone dipropionate 0.5 mg/g cutaneous foam (Cal/BD foam) on itch, itch-related sleep loss and HRQoL versus foam vehicle. Read More
J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.
Head Research & Head Outpatient Clinic, Department of Dermatology, University Hospital Zürich, Switzerland.
We read with interest and with full consent the new consensus-based European guidelines for the treatment of atopic eczema, Part II . However, we would like to comment on the section on microbial textiles where the recommendation to use silk garments with permanent antimicrobial in the management of children with moderate to severe eczema is raised. On the basis of an UK multicenter clinical trial which seemed to show that silk garments with permanent antimicrobial were ineffective in the treatment of children with atopic eczema, the guidelines deny now any clinical benefit of AEGIS-coated silk textiles in children with atopic eczema and this contrary to the previous two guidelines . Read More
Contact Dermatitis 2018 Dec 5. Epub 2018 Dec 5.
University of Groningen, University Medical Center Groningen, Department of Dermatology, The Netherlands.
Background: Analyses of the European Surveillance System on Contact Allergies (ESSCA) database have focused primarily on prevalence of contact allergies to the European baseline series; overall and in subgroups of patients. However, affected body sites have hitherto not been addressed.
Objective: To determine prevalence of contact allergies for distinct body sites in patients with allergic contact dermatitis (ACD). Read More
Laryngoscope 2018 Dec 5. Epub 2018 Dec 5.
Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.
Objectives/hypothesis: Currently, due to the rarity of pathology, there are limited data surrounding outcomes of pediatric skull base surgery. Traditionally, surgeons have proceeded with caution when electing endonasal endoscopic transsellar/transplanum approaches to the skull base in pediatric patients due to poor sphenoid pneumatization. In this study, we review outcomes of endoscopic pediatric skull base surgery based on sphenoid pneumatization patterns. Read More
Cell Biol Toxicol 2018 Dec 5. Epub 2018 Dec 5.
Tianjin Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, Department of Histology and Embryology, School of Medicine, Nankai University, Tianjin, 300071, China.
The effects of teas on embryonic development are still known little. The objective of this study was to compare and analyze developmental effects of green tea, delicate flavor oolong tea, strong flavor oolong tea, black tea, and pu'er tea using zebrafish embryos. Embryos were exposed in tea solutions from one-cell stage; the morphology, locomotor capacity, and gene expression of embryos or larvae were analyzed. Read More