76,794 results match your criteria Head and Neck Cancer - Squamous Cell Carcinoma


Cost-Effectiveness of Sentinel Lymph Node Biopsy for Head and Neck Cutaneous Squamous Cell Carcinoma.

J Surg Res 2019 Apr 17;241:15-23. Epub 2019 Apr 17.

Division of Surgical Oncology, Department of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey. Electronic address:

Background: Sentinel lymph node biopsy (SLNB) has shown promise in identifying subclinical nodal metastasis in patients with high-risk cutaneous squamous cell carcinoma. However, low metastasis rates may indicate that performing such a procedure in all patients may be unnecessary and costly.

Materials And Methods: A decision model was developed to analyze costs and survival in patients with head and neck cutaneous squamous cell carcinoma based on their tumor and nodal metastasis staging and whether or not they received an SLNB. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.040DOI Listing

Increasing incidence rates of oropharyngeal squamous cell carcinoma in Germany and significance of disease burden attributed to human papillomavirus.

Cancer Prev Res (Phila) 2019 Apr 19. Epub 2019 Apr 19.

Department of Otolaryngology, Head and Neck Surgery, University Hospital Cologne.

Increasing incidences of head and neck cancers and rising proportions of these associated with human papilloma virus (HPV), especially in the oropharynx, have been reported in international studies. So far, the trends and contribution of HPV to the number of newly diagnosed cases of oropharyngeal squamous cell carcinomas (OPSCC) in Germany are uncertain. We investigated HPV association and incidence rates in a cohort of consecutively included patients with OPSCC in Giessen 2000-2017, and compared our results with regional (Giessen and the federal state of Hesse), national (Germany) and international (USA) databases. Read More

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http://cancerpreventionresearch.aacrjournals.org/lookup/doi/
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http://dx.doi.org/10.1158/1940-6207.CAPR-19-0098DOI Listing
April 2019
1 Read

Platinum rechallenge in recurrent head and neck squamous cell carcinoma after primary chemoradiation.

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Apr 16. Epub 2019 Apr 16.

Head and Neck Oncology, Centre François Baclesse, Avenue du Général Harris, 14000 Caen, France; Radiotherapy Department, Centre Francois Baclesse, Caen, France.

Objective: To evaluate platinum rechallenge efficacy and tolerance in patients presenting recurrent head and neck squamous cell carcinoma (HNSCC) after platinum-based chemoradiation.

Materials And Methods: We retrospectively included all patients treated from 2007 to 2016 by platinum-based polychemotherapy for recurrence of HNSCC previously treated by primary or postsurgical platinum-based chemoradiation. The primary end-point was disease control rate (DCR) on platinum rechallenge. Read More

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http://dx.doi.org/10.1016/j.anorl.2019.04.007DOI Listing

Innervation of cervical carcinoma is mediated by cancer-derived exosomes.

Gynecol Oncol 2019 Apr 16. Epub 2019 Apr 16.

Sanford Research, Cancer Biology and Immunotherapy Group, 2301 East 60th St north, Sioux Falls, SD 57104, USA. Electronic address:

Objective: Recently, our laboratory identified sensory innervation within head and neck squamous cell carcinomas (HNSCCs) and subsequently defined a mechanism whereby HNSCCs promote their own innervation via the release of exosomes that stimulate neurite outgrowth. Interestingly, we noted that exosomes from human papillomavirus (HPV)-positive cell lines were more effective at promoting neurite outgrowth than those from HPV-negative cell lines. As nearly all cervical tumors are HPV-positive, we hypothesized that these findings would extend to cervical cancer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258193114
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http://dx.doi.org/10.1016/j.ygyno.2019.04.651DOI Listing
April 2019
1 Read

Bioactive sphingolipid profile in a xenograft mouse model of head and neck squamous cell carcinoma.

PLoS One 2019 19;14(4):e0215770. Epub 2019 Apr 19.

Departments of Medicine and Biochemistry & the Stony Brook Cancer Center at Stony Brook University, Stony Brook, New York, United States of America.

The purpose of this study was to determine the profile of bioactive sphingolipids in xenograft mouse tissues of head and neck squamous cell carcinoma. We utilized UHPLC-MS/MS to determine the profile of full set of ceramides, sphingosine, and sphingosine 1-phosphate in this xenograft mouse model. The tissues isolated and investigated were from brain, lung, heart, liver, spleen, kidney, bladder, tumors and blood. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215770PLOS

Similarities in mRNA expression of peripheral blood drug metabolizing enzymes and cancer marker genes with biopsy samples of head and neck cancer patients.

Biomarkers 2019 Apr 19:1-30. Epub 2019 Apr 19.

a Developmental Toxicology Laboratory, System Toxicology & Health Risk Assessment Group , CSIR-Indian Institute of Toxicology Research (CSIR-IITR) , Vishvigyan Bhawan, 31, Mahatma Gandhi Marg , Lucknow - 226001 , U.P , India.

Purpose: To develop peripheral blood mRNA expression profiles of drug metabolizing enzymes (DMEs) as a surrogate to monitor tobacco induced head & neck squamous cell carcinoma (HNSCC), attempts were made to investigate i) similarities in alterations with the cancer marker genes in biopsy samples, and ii) if alterations similar to that seen in biopsy samples are reflected in peripheral blood.

Methods: Total RNA from eight soft gingival tissues and eight biopsy samples of HNSCC patients and total DNA and RNA from blood of healthy controls (n = 150) and HNSCC patients (n = 150) was processed for expression and genotyping studies. Blood from patients receiving chemo-radiotherapy was processed for follow-up study Results: qRT-PCR revealed significant increase in mRNA expression of DMEs in biopsy and blood samples of HNSCC patients when compared to controls. Read More

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https://www.tandfonline.com/doi/full/10.1080/1354750X.2019.1
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http://dx.doi.org/10.1080/1354750X.2019.1609090DOI Listing
April 2019
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The Double-Edged Sword-How Human Papillomaviruses Interact With Immunity in Head and Neck Cancer.

Front Immunol 2019 2;10:653. Epub 2019 Apr 2.

State Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, China.

Patients with human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) have remarkably better prognosis, which differs from HPV-negative oropharyngeal squamous cell carcinoma (OPSCC) with respect to clinical, genomic, molecular, and immunological aspects, especially having the characteristics of high levels of immune cell infiltration and high degrees of immunosuppression. This review will summarize immune evasion mechanisms in HPV-positive HNSCC, analyze the host various immune responses to HPV and abundant numbers of infiltrating immune cell, and discuss the differences between HPV-positive HNSCC with cervical cancer. A deeper understanding of the immune landscape will help new concepts to emerge in immune-checkpoint oncology, which might be a valuable add-on to established concepts. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00653
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http://dx.doi.org/10.3389/fimmu.2019.00653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454067PMC
April 2019
1 Read

Changes in the 8th Edition of the American Joint Committee on Cancer (AJCC) Staging of Head and Neck Cancer: Rationale and Implications.

Curr Oncol Rep 2019 Apr 17;21(6):52. Epub 2019 Apr 17.

Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.

Purpose Of Review: The objectives of this article are to review the major changes in the staging of head and neck cancers and the rationale for the modifications.

Recent Findings: Information gathered from various institutional reports lead to a better understanding of the clinical and biological behavior of head and neck tumors, resulting in distinct outcomes, which were used to update the staging system. This article reviews the changes in the staging of head and neck cancers published in the 8th edition of the AJCC/UICC TNM staging system. Read More

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http://dx.doi.org/10.1007/s11912-019-0799-xDOI Listing

Differential expression of Helios, Neuropilin-1 and FoxP3 in head and neck squamous cell carcinoma (HNSCC) patients.

3 Biotech 2019 May 16;9(5):178. Epub 2019 Apr 16.

School of Life Sciences, B S Abdur Rahman Crescent Institute of Science and Technology, GST Road, Vandalur, Chennai, Tamil Nadu 600048 India.

In recent years, studies have begun to explore the immune involvement in head and neck tumors. Advanced stage head and neck squamous cell carcinoma (HNSCC) has a poor prognosis with low survival rates with high level of immune infiltrates. Tregs (regulatory T cells) play a crucial role in constructing an immunosuppressive tumor microenvironment. Read More

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http://dx.doi.org/10.1007/s13205-019-1707-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468022PMC

A Six-Gene-Based Prognostic Model Predicts Survival in Head and Neck Squamous Cell Carcinoma Patients.

J Maxillofac Oral Surg 2019 Jun 24;18(2):320-327. Epub 2019 Jan 24.

3Department of Pathology, The University of Iowa, 500 Newton Road, #ML 1132, Iowa City, IA 52242-5000 USA.

Background And Objective: Head and neck cancer is a malignant tumor that begins in the head and neck region, and has the sixth highest incidence worldwide. Previous studies have indicated several prognostic markers for head and neck squamous cell carcinoma (HNSCC), but due to poor accuracy and sensitivity of these clinical characteristic markers attention has been gradually switched to molecular biomarkers. This study aimed to sort out the mRNAs correlated with patient survival time to establish an mRNA combination prognostic biomarker model for HNSCC patient risk stratification, providing optimal therapeutic regimens and improving patient prognosis. Read More

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http://dx.doi.org/10.1007/s12663-019-01187-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441444PMC

Xenotropic and polytropic retrovirus receptor 1 (XPR1) promotes progression of tongue squamous cell carcinoma (TSCC) via activation of NF-κB signaling.

J Exp Clin Cancer Res 2019 Apr 17;38(1):167. Epub 2019 Apr 17.

Department of Head and Neck, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, People's Republic of China.

Background: Xenotropic and polytropic retrovirus receptor 1 (XPR1), a previously identified cellular receptor for several murine leukemia viruses, plays a role in many pathophysiological processes. However, the role of XPR1 in human cancers has not yet been characterized.

Methods: Real-time PCR and western blotting assay were used to measure the expression of XPR1 in tongue squamous cell carcinoma (TSCC) tissues. Read More

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http://dx.doi.org/10.1186/s13046-019-1155-6DOI Listing

Independent validation of tumour volume, cancer stem cell markers and hypoxia-associated gene expressions for HNSCC after primary radiochemotherapy.

Clin Transl Radiat Oncol 2019 May 18;16:40-47. Epub 2019 Mar 18.

German Cancer Consortium (DKTK) Partner Site Dresden, Germany and German Cancer Research Center (DKFZ), Heidelberg, Germany.

Objective: To independently validate the impact of tumour volume, p16 status, cancer stem cell (CSC) marker expression and hypoxia-associated gene signatures as potential prognostic biomarkers for patients with locally advanced head and neck squamous cell carcinoma (HNSCC), who underwent primary radiotherapy or radiochemotherapy (RCTx). These markers have previously been reported in a study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG) (Linge et al., 2016). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24056308183011
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http://dx.doi.org/10.1016/j.ctro.2019.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449705PMC
May 2019
2 Reads

Putative biomarkers of malignant transformation of sinonasal inverted papilloma into squamous cell carcinoma.

J Int Med Res 2019 Apr 16:300060519838385. Epub 2019 Apr 16.

1 Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Objective: To compare genome-wide DNA methylation between samples of sinonasal inverted papilloma (SNIP) and squamous cell carcinoma (SCC) samples in order to identify aberrantly methylated genes that might be involved in malignant transformation.

Methods: Tissue samples were collected from patients. DNA methylation in C-phosphate-G islands and gene promoters was analysed using a DNA methylation microarray kit. Read More

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http://dx.doi.org/10.1177/0300060519838385DOI Listing
April 2019
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F-FDG-PET Can Predict Microvessel Density in Head and Neck Squamous Cell Carcinoma.

Cancers (Basel) 2019 Apr 15;11(4). Epub 2019 Apr 15.

Department of Nuclear Medicine, University Hospital of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany.

: Positron emission tomography (PET) with F-fluordeoxyglucose (F-FDG) plays an essential role in the staging and tumor monitoring of head and neck squamous cell carcinoma (HNSCC). Microvessel density (MVD) is one of the clinically important histopathological features in HNSCC. The purpose of this study was to analyze possible associations between F-FDG-PET findings and MVD parameters in HNSCC. Read More

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https://www.mdpi.com/2072-6694/11/4/543
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http://dx.doi.org/10.3390/cancers11040543DOI Listing
April 2019
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The Prognostic Roles of Pretreatment Circulating Tumor Cells, Circulating Cancer Stem-Like Cells, and Programmed Cell Death-1 Expression on Peripheral Lymphocytes in Patients with Initially Unresectable, Recurrent or Metastatic Head and Neck Cancer: An Exploratory Study of Three Biomarkers in One-time Blood Drawing.

Cancers (Basel) 2019 Apr 15;11(4). Epub 2019 Apr 15.

Chang Gung University, College of Medicine, Taoyuan 333, Taiwan.

Circulating tumor cells (CTCs) and immune status are strongly related to cancer prognosis, although few studies have examined both factors. This prospective observational study (ClinicalTrials.gov: NCT02420600) evaluated whether CTCs, circulating cancer stem-like cells (cCSCs), and peripheral lymphocytes with/without Programmed cell death protein 1 (PD-1) expression were associated with prognosis among patients receiving palliative chemotherapy for initially unresectable, recurrent/metastatic head and neck squamous cell carcinoma (rmHNSCC). Read More

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http://dx.doi.org/10.3390/cancers11040540DOI Listing

Clinical effect of postoperative chemoradiotherapy in resected advanced laryngeal squamous cell carcinoma.

Oncol Lett 2019 May 4;17(5):4717-4725. Epub 2019 Mar 4.

Department of Otorhinolaryngology-Head and Neck Surgery, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai 200031, P.R. China.

Laryngeal squamous cell carcinoma (LSCC) is one of the most prevalent types of head and neck malignancies. Advanced LSCC has failed to demonstrate a satisfactory prognosis, despite the progresses in the diagnosis and treatment, and the optimal treatment modality continues to be debated. To evaluate the clinical utility and survival outcomes of adjuvant chemoradiotherapy (CRT) for patients with resected advanced LSCC, a retrospective analysis of 232 patients with LSCC who had undergone total laryngectomy and neck dissection between 2005 and 2010 was conducted. Read More

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http://dx.doi.org/10.3892/ol.2019.10104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447886PMC
May 2019
1 Read

Depletion of PCAT-1 in head and neck cancer cells inhibits tumor growth and induces apoptosis by modulating c-Myc-AKT1-p38 MAPK signalling pathways.

BMC Cancer 2019 Apr 15;19(1):354. Epub 2019 Apr 15.

Department of Pathology, Saint Louis University, 1100 South Grand Boulevard, St. Louis, MO, 63104, USA.

Background: Head and neck squamous cell carcinoma (HNSCC) represents one of the most common malignancies worldwide with a high mortality rate mainly due to lack of early detection markers, frequent association with metastasis and aggressive phenotype. Recently, long non-coding RNAs (lncRNAs) have been shown to have important regulatory roles in human cancers. The lncRNA prostate cancer-associated transcript 1 (PCAT-1) showed potential oncogenic roles in different cancers, however its role in HNSCC is not known. Read More

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http://dx.doi.org/10.1186/s12885-019-5562-zDOI Listing
April 2019
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Targeted Therapies and Immune-Checkpoint Inhibition in Head and Neck Squamous Cell Carcinoma: Where Do We Stand Today and Where to Go?

Cancers (Basel) 2019 Apr 3;11(4). Epub 2019 Apr 3.

Department of Radiation Oncology, Rämistrasse 100, University Hospital Zurich, 8091 Zürich, Switzerland.

With an increased understanding of the tumor biology of squamous cell carcinoma of the head and neck (SCCHN), targeted therapies have found their way into the clinical treatment routines against this entity. Nevertheless, to date platinum-based cytostatic agents remain the first line choice and targeting the epidermal growth factor-receptor (EGFR) with combined cetuximab and radiation therapy remains the only targeted therapy approved in the curative setting. Investigation of immune checkpoint inhibitors (ICI), such as antibodies targeting programmed cell death protein 1 (PD-1) and its ligand PD-L1, resulted in a change of paradigms in oncology and in the first approval of new drugs for treating SCCHN. Read More

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http://dx.doi.org/10.3390/cancers11040472DOI Listing
April 2019
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ROS Production and Distribution: A New Paradigm to Explain the Differential Effects of X-ray and Carbon Ion Irradiation on Cancer Stem Cell Migration and Invasion.

Cancers (Basel) 2019 Apr 3;11(4). Epub 2019 Apr 3.

Laboratoire de Radiobiologie Cellulaire et Moléculaire, Faculté de Médecine Lyon-Sud, Univ Lyon, Université Lyon 1, UMR CNRS5822/IN2P3, IPNL, PRISME, 69921 Oullins Cedex, France.

Although conventional radiotherapy promotes the migration/invasion of cancer stem cells (CSCs) under normoxia, carbon ion (C-ion) irradiation actually decreases these processes. Unraveling the mechanisms of this discrepancy, particularly under the hypoxic conditions that pertain in niches where CSCs are preferentially localized, would provide a better understanding of the origins of metastases. Invasion/migration, proteins involved in epithelial-to-mesenchymal transition (EMT), and expression of MMP-2 and HIF-1α were quantified in the CSC subpopulations of two head-and-neck squamous cell carcinoma (HNSCC) cell lines irradiated with X-rays or C-ions. Read More

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http://dx.doi.org/10.3390/cancers11040468DOI Listing

Assessment of PD-L1 mRNA and protein expression in non-small cell lung cancer, head and neck squamous cell carcinoma and urothelial carcinoma tissue specimens using RNAScope and immunohistochemistry.

PLoS One 2019 15;14(4):e0215393. Epub 2019 Apr 15.

Precision Medicine Laboratories, Precision Medicine and Genomics, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Cambridge, United Kingdom.

Four immunohistochemistry (IHC) diagnostic assays have been approved for tumour PD-L1 protein assessment in the clinic. However, mRNA detection by in situ hybridisation (ISH) could be utilised as an alternative to protein detection. Detecting spatial changes in gene expression provides vital prognostic and diagnostic information, particularly in immune oncology where the phenotype, cellular infiltration and immune activity status may be associated with patient survival. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215393PLOS
April 2019
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Survival of oral tongue squamous cell carcinoma in young adults.

Head Neck 2019 Apr 15. Epub 2019 Apr 15.

Department of Otolaryngology, NYU Langone Health, New York, New York.

Background: Small cohort studies have suggested oral tongue squamous cell carcinoma (OTSCC) could be associated with worse prognosis in individuals younger than 40.

Methods: We compared the survival of all OTSCC cases in the National Cancer Database under 40 years old with those older than 40, excluding patients over 70. Cox regression and propensity score matched (PSM) survival analyses were performed. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hed.25772
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http://dx.doi.org/10.1002/hed.25772DOI Listing
April 2019
1 Read

Myoepithelial Cell Carcinoma of the Oral Tongue: Case Report and Review of the Literature.

Clin Med Insights Oncol 2019 2;13:1179554919838254. Epub 2019 Apr 2.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of New Mexico Hospital, UNM School of Medicine, Albuquerque, NM, USA.

Background: Myoepithelial cell carcinoma is a rare malignant neoplasm of salivary gland origin that typically presents in the parotid gland and minor salivary glands. It has been described previously in head and neck sites such as buccal mucosa, alveolar ridge, and base of tongue.

Methods: A 55-year-old man presented with 30 years of right-sided tongue pain and 10 years of gradually worsening ulceration. Read More

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http://dx.doi.org/10.1177/1179554919838254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448097PMC
April 2019
2 Reads

"Melting Lymph Node Sign": The Endobronchial Ultrasound Pattern of Cystic Mediastinal Nodal Metastases.

Ann Thorac Surg 2019 Apr 11. Epub 2019 Apr 11.

Pathology Unit, Policlinico Sant'Orsola-Malpighi, Bologna, Italy.

Cystic change in metastatic lymph nodes occurs in certain types of tumors (i.e., papillary thyroid carcinoma, squamous cell carcinoma of the Waldeyer's ring) and it is usually observed in the head and neck region. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.03.038DOI Listing
April 2019
1 Read

CD100-Plexin-B1 induces Epithelial-Mesenchymal Transition of head and neck squamous cell carcinoma and promotes metastasis.

Cancer Lett 2019 Apr 11. Epub 2019 Apr 11.

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China. Electronic address:

Head and neck squamous cell carcinoma (HNSCC) is one of the most lethal cancers mainly due to the high rate of metastasis. Here, we find that the expression level of CD100 in HNSCC is positively correlated with the T category, pathological grade and lymph node metastasis of the tumor. The level of soluble CD100 (sCD100) is highly increased in serum of HNSCC patients, and sCD100 markedly induces the epithelial-mesenchymal transition (EMT) of HNSCC through its receptor, Plexin-B1 (PlxnB1), and promotes the metastasis in a xenograft mouse model. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.04.013DOI Listing
April 2019
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Are Comorbidities Associated With Overall Survival in Patients With Oral Squamous Cell Carcinoma?

J Oral Maxillofac Surg 2019 Mar 19. Epub 2019 Mar 19.

Attending Physician, Department of Clinical Oncology, Miguel Servet University Hospital, Zaragoza, Spain.

Purpose: Oral squamous cell carcinoma (OSCC) is a highly prevalent type of immunogenic cancer with a low survival rate in patients with comorbidities owing to toxic habits.

Materials And Methods: A retrospective cohort study was conducted of patients with resectable OSCC at a tertiary Spanish hospital from 2011 to 2014. The primary predictor variables were comorbidity and immune biomarkers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02782391193027
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http://dx.doi.org/10.1016/j.joms.2019.03.007DOI Listing
March 2019
2 Reads

PYHIN genes as potential biomarkers for prognosis of human papillomavirus-positive or -negative head and neck squamous cell carcinomas.

Mol Biol Rep 2019 Apr 12. Epub 2019 Apr 12.

Department of Public Health and Pediatric Sciences, University of Turin, Via Santena 9, 10126, Turin, Italy.

The aim of the present study is to determine the expression levels of PYHIN (IFI16 and AIM2) and APOBEC3 (A3A, A3B, A3C, A3D, A3F, A3G, and A3H) gene family members in a cohort of patients with head and neck squamous cell carcinoma (HNSCC) and assess their potential correlation with human papillomavirus (HPV) infection status, clinical characteristics, and survival. For this purpose, 34 HNSCC tissue specimens along with healthy surrounding mucosa were collected from patients surgically treated for HNSCC. Nucleic acids were isolated to assess the presence of HPV and the expression levels of selected molecular markers. Read More

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http://dx.doi.org/10.1007/s11033-019-04795-7DOI Listing
April 2019
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Head and neck squamous cell carcinoma: prediction of cervical lymph node metastasis by dual-energy CT texture analysis with machine learning.

Eur Radiol 2019 Apr 12. Epub 2019 Apr 12.

Department of Radiology and Research Institute of the McGill University Health Centre, McGill University, Room C02.5821, 1001 Decarie Blvd, Montreal, QC, H4A 3J1, Canada.

Objectives: This study was conducted in order to evaluate a novel risk stratification model using dual-energy CT (DECT) texture analysis of head and neck squamous cell carcinoma (HNSCC) with machine learning to (1) predict associated cervical lymphadenopathy and (2) compare the accuracy of spectral versus single-energy (65 keV) texture evaluation for endpoint prediction.

Methods: Eighty-seven patients with HNSCC were evaluated. Texture feature extraction was performed on virtual monochromatic images (VMIs) at 65 keV alone or different sets of multi-energy VMIs ranging from 40 to 140 keV, in addition to iodine material decomposition maps and other clinical information. Read More

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http://dx.doi.org/10.1007/s00330-019-06159-yDOI Listing

Expression of vimentin (VIM) and metastasis-associated 1 (MTA1) protein in laryngeal squamous cell carcinoma are associated with prognostic outcome of patients.

Am J Otolaryngol 2019 Apr 3. Epub 2019 Apr 3.

Department of Vascular Surgery, University General Hospital "Attikon", Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Purpose: Laryngeal squamous cell carcinoma (LSCC), a common type of head and neck cancer, is associated with high rates of metastasis and recurrence. In this study, we investigated the potential combinatorial prognostic value of NOTCH1, Vimentin (VIM), and Metastasis-associated 1 (MTA1) protein in LSCC, using immunohistochemistry.

Materials And Methods: Tissue specimens from 69 patients with LSCC were immunohistochemically evaluated for the protein expression of NOTCH1, VIM, and MTA1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01960709193025
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http://dx.doi.org/10.1016/j.amjoto.2019.04.002DOI Listing
April 2019
1 Read

Effects of adjuvant radiation therapy on survival for patients with resected primary tracheal carcinoma: an analysis of the National Cancer Database.

Jpn J Clin Oncol 2019 Apr 12. Epub 2019 Apr 12.

Department of Radiation Oncology, University of Louisville Hospital, Louisville KY, USA.

Objective(s): To identify predictors for receiving adjuvant radiation therapy (RT) and investigate the impact of adjuvant RT on survival for patients with resected primary tracheal carcinoma (PTC).

Methods: The National Cancer database was queried for patients with PTC diagnosed from 2004 to 2014 undergoing resection. Patients who died within 30 days of resection were excluded to minimize immortal time bias. Read More

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http://dx.doi.org/10.1093/jjco/hyz047DOI Listing
April 2019
35 Reads

Epidemiology and treatment trends for primary tracheal squamous cell carcinoma.

Laryngoscope 2019 Apr 12. Epub 2019 Apr 12.

Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, U.S.A.

Objective: Management of tracheal squamous cell carcinoma (TSCC) has been complicated by the lack of prognostic data and staging. We describe the epidemiology of TSCC and current treatment approaches.

Methods: Five hundred thirty-two adult patients with primary TSCC from 2004 to 2012 in the National Cancer Database were identified. Read More

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http://dx.doi.org/10.1002/lary.27994DOI Listing

Number of nodal metastases and prognosis in metastatic cutaneous squamous cell carcinoma of the head and neck.

ANZ J Surg 2019 Apr 11. Epub 2019 Apr 11.

Department of Head and Neck Surgery, Liverpool Hospital, Sydney, New South Wales, Australia.

Background: Existing prognostic systems for metastatic cutaneous squamous cell carcinoma of the head and neck (cSCCHN) do not discriminate between the number of involved nodes beyond single versus multiple. This study aimed to determine if the number of metastatic lymph nodes is an independent prognostic factor in metastatic cSCCHN and whether it provides additional prognostic information to the American Joint Committee on Cancer (AJCC) staging.

Methods: We retrospectively analysed 101 patients undergoing curative intent treatment for metastatic cSCCHN to parotid and/or neck nodes by surgery +/- radiotherapy at Liverpool Hospital, Sydney, Australia. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ans.15086
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http://dx.doi.org/10.1111/ans.15086DOI Listing
April 2019
6 Reads
1.118 Impact Factor

Prognostic value of the nodal yield in head and neck squamous cell carcinoma: A systematic review.

Head Neck 2019 Apr 10. Epub 2019 Apr 10.

Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.

Objective: Literature analysis on the prognostic factor of the nodal yield (NY) in neck dissections (NDs), which in general surgical oncology is a strong prognosticator and quality-of-care marker.

Methods: We performed a systematic review of all PubMed and Embase publications until June 30, 2018 screening for data on NY as prognosticator and overall survival (OS) as outcome in patients with head and neck squamous cell carcinoma (HNSCC). Risk for bias was asserted by application of the Quality In Prognosis Studies tool. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hed.25764
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http://dx.doi.org/10.1002/hed.25764DOI Listing
April 2019
6 Reads

Performance of the American Joint Committee on Cancer Staging Manual, 8th Edition vs the Brigham and Women's Hospital Tumor Classification System for Cutaneous Squamous Cell Carcinoma.

JAMA Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Importance: Brigham and Women's tumor classification (BWH) better predicts poor outcomes than American Joint Committee on Cancer (AJCC) 7th edition (AJCC 7). AJCC 8th edition (AJCC 8) has not been evaluated.

Objectives: To compare BWH and AJCC 8 tumor classifications for head and neck cutaneous squamous cell carcinoma (HNCSCC). Read More

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http://dx.doi.org/10.1001/jamadermatol.2019.0032DOI Listing
April 2019
2 Reads

Comparing high-dose cisplatin with cisplatin-based combination chemotherapy in definitive concurrent chemoradiation setting for locally advanced head and neck squamous cell carcinoma (LAHNSCC).

Cancer Med 2019 Apr 9. Epub 2019 Apr 9.

Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Background: High-dose cisplatin (Cis) is a preferred systemic agent for concurrent chemoradiation (CRT) in locally advanced head and neck squamous cell cancer (LAHNSCC) patients. As some patients are unable to tolerate Cis, this study compares the toxicity and efficacy of weekly cisplatin-paclitaxel (CP) regimen with Cis.

Methods: Patients with LAHNSCC receiving definitive chemoradiation either with Cis (Cisplatin-100 mg/m q3w x 3) or CP (Cisplatin-20 mg/m ; Paclitaxel-30 mg/m qw x7) were included. Read More

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http://dx.doi.org/10.1002/cam4.2139DOI Listing
April 2019
1 Read

Intratumor heterogeneity of PD-L1 expression in head and neck squamous cell carcinoma.

Br J Cancer 2019 Apr 10. Epub 2019 Apr 10.

Department of Oncology, Section of Radiotherapy, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Intratumor heterogeneity may contribute to the ambiguous clinical results on PD-L1 status as a predictor for immunotherapy response in patients with HNSCC. This decreases the utility of PD-L1 expression from single tumour biopsies as a predictive biomarker. In this prospective study, intratumor heterogeneity of PD-L1 expression in HNSCC was investigated with both Tumour Proportion Score (TPS) and Combined Positive Score (CPS). Read More

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http://dx.doi.org/10.1038/s41416-019-0449-yDOI Listing

Necrotizing Sialometaplasia of the Hypopharynx.

Ear Nose Throat J 2019 Apr 9:145561319840826. Epub 2019 Apr 9.

1 Department of Otolaryngology, Harvard Medical School, Massachusetts Eye and Ear, Boston, MA, USA.

Necrotizing sialometaplasia (NSM) is a benign, reactive metaplastic condition of the minor salivary gland tissue typically seen in the setting of injury, chemical or traumatic, and is nonneoplastic and self-limited. The diagnosis may be challenging as it may clinically mimic malignancy. We present the case of a 74-year-old male with a 1 pack per day smoking history for 60 years who presented with a reported 20-pound weight loss, dysphagia, and dysphonia progressing over the course of 6 months and found to have a 3. Read More

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http://dx.doi.org/10.1177/0145561319840826DOI Listing
April 2019
2 Reads

Apatinib and S-1 combination therapy for the treatment of advanced head and neck neoplasms: Three case reports.

J Cancer Res Ther 2019 ;15(2):442-446

Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.

Apatinib, one of the novel oral antiangiogenic agents, shows survival benefits in treating advanced or metastatic gastric adenocarcinoma. However, its efficacy in treating advanced head and neck neoplasms has not been reported. Herein, three elderly men with advanced head and neck neoplasms were treated with apatinib and S-1. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_894_18DOI Listing
January 2019
2 Reads

Nimotuzumab plus chemotherapy with docetaxel, cisplatin, 5-fluorouracil for locally advanced head and neck squamous cell carcinoma: A clinical study.

J Cancer Res Ther 2019 ;15(2):312-316

Department of Oromaxillofacial Head and Neck Surgery, College of Medicine, Affiliated Xuzhou Hospital, Southeast University, Xuzhou, Jiangsu 221000, China.

Background: A clinical study was conducted to determine the efficacy of nimotuzumab combined with docetaxel, cisplatin, and 5-fluorouracil (TPF) for patients with locally advanced head and neck squamous cell carcinoma (HNSCC) after surgery and conformal radiotherapy.

Methods: Thirty-one HNSCC patients received three courses of chemotherapy every 21 days, at a dose of 75 mg/m of docetaxel and cisplatin on day 1 and 750 mg/m of 5-fluorouracil on days 1-5 followed by 200 mg/m/week of nimotuzumab on week 1-2 (day 6-21).

Results: After sequential therapy, complete and partial responses were observed in 10 (32. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_889_17DOI Listing
January 2019
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Radiation Therapy Impact on Lymph Node Yield in Patients With Laryngeal Squamous Cell Carcinoma.

Ear Nose Throat J 2019 Apr 8:145561319839790. Epub 2019 Apr 8.

1 Department of Otolaryngology-Head and Neck Surgery, Augusta University, Augusta, GA, USA.

Background: A lymph node yield (LNY) over 20 is considered a quality metric for lateral neck dissection to ensure an oncologic representative sample. Anecdotally, however, LNY in patients undergoing neck dissection after radiation therapy (RT) is lower due to atrophy and fibrosis.

Objective: To determine whether preoperative RT decreases LNY in patients with laryngeal cancers undergoing surgery. Read More

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http://dx.doi.org/10.1177/0145561319839790DOI Listing
April 2019
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Genetic Susceptibility in Head and Neck Squamous Cell Carcinoma in a Spanish Population.

Cancers (Basel) 2019 Apr 7;11(4). Epub 2019 Apr 7.

Medical Oncology Service, University Hospital of Salamanca-IBSAL, 37007 Salamanca, Spain.

Despite classical environmental risk factors like tobacco, alcohol or viral infection, not all individuals develop head and neck cancer. Therefore, identification of the genetic susceptibility produced by single nucleotide polymorphisms (SNPs) is an important task. A total of 296 human papillomavirus negative head and neck cancer (HNC) patients (126 laryngeal, 100 pharyngeal and 70 oral cavity) were included in the study, involving 29 candidate SNPs in genes within important carcinogenic pathways (oncogenesis and tumour suppression, DNA repair, inflammation, oxidation and apoptosis). Read More

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http://dx.doi.org/10.3390/cancers11040493DOI Listing
April 2019
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Patient perspectives and treatment regret after de-escalated chemoradiation for human papillomavirus-positive oropharyngeal cancer: Findings from a phase II trial.

Head Neck 2019 Apr 8. Epub 2019 Apr 8.

Department of Radiation Oncology, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California.

Background: We evaluated priorities, expectations, and regret among patients treated on a phase II trial of de-escalated chemoradiation for human papillomavirus (HPV)-positive oropharyngeal cancer.

Methods: Eligibility included stage III/IV squamous cell carcinoma of the oropharynx, p16-positivity, age ≥18 years, and Zubrod score 0-1. Participants were surveyed with validated measures evaluating their treatment experience. Read More

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http://dx.doi.org/10.1002/hed.25760DOI Listing
April 2019
1 Read

Aesthetic single-stage vermilion reconstruction using facial artery musculomucosal flap and radial forearm free flap following cancer resection: A case report.

Microsurgery 2019 Apr 8. Epub 2019 Apr 8.

Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.

Reconstruction of defects measuring approximately two-thirds of the lower lip width is traditionally reconstructed utilizing loco-regional flap utilizing lip and cheek tissues. This often results in microstomia and unsatisfactory aesthetic outcome. This may hinder the psychosocial aspect of a recovering cancer survivor. Read More

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http://dx.doi.org/10.1002/micr.30456DOI Listing
April 2019
4 Reads

Zinc finger E‑box binding homeobox 2 functions as an oncogene in human laryngeal squamous cell carcinoma.

Mol Med Rep 2019 Apr 4. Epub 2019 Apr 4.

Department of Biochemistry, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.

Zinc finger E‑box binding homeobox 2 (ZEB2) is a member of the Zfh1 family of two‑handed zinc finger/homeodomain proteins. To date, the role of ZEB2 in human laryngeal carcinoma has not been clearly defined. In the present study, the level of ZEB2 expression in laryngeal squamous cell carcinoma (LSCC) tissues and adjacent normal tissues was evaluated using reverse transcription‑quantitative polymerase chain reaction. Read More

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http://www.spandidos-publications.com/10.3892/mmr.2019.10126
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http://dx.doi.org/10.3892/mmr.2019.10126DOI Listing
April 2019
11 Reads

Intervening in the Acute Phase of Postradiation Carotid Blowout Syndrome.

Int Arch Otorhinolaryngol 2019 Apr 1;23(2):172-177. Epub 2019 Mar 1.

Department of Neurosurgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

 Acute carotid blowout syndrome (aCBS) is a severe complication of head and neck cancer (HNC). It can be defined as a rupture of the extracranial carotid arteries, or one of their branches, that causes life-threatening hemorrhage, and which nowadays can be treated with urgent endovascular intervention.  We retrospectively evaluate the endovascular management of aCBS and its outcome in years of survival. Read More

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http://dx.doi.org/10.1055/s-0038-1676660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449140PMC
April 2019
2 Reads

Enteral Access Potentially Endangers Esophageal Carcinoma Patients Under Multi-modality Therapy: A Population-based Study.

Anticancer Res 2019 Apr;39(4):2227-2232

Institute of Medical Sciences, Tzu-Chi University, Hualien, Taiwan, R.O.C.

Background/aim: This study aimed to evaluate the clinical outcome of esophageal cancer (EC) patients with enteral access (EA) undergoing multimodality therapy.

Patients And Methods: This retrospective study analyzed data between 1997 and 2012 in Taiwan using the National Health Insurance Research Database. Patients with newly-diagnosed EC undergoing multimodality therapy were identified and classified as either EA group or no-EA group. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13338DOI Listing
April 2019
6 Reads

Prognostic Roles of SCC Antigen, CRP and CYFRA 21-1 in Oral Cavity Squamous Cell Carcinoma.

Anticancer Res 2019 Apr;39(4):2025-2033

Department of Otolaryngology - Head & Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan, R.O.C.

Background/aim: Tumor-related and inflammation-related markers were reported to be prognostic in cancer patients. In this study, we evaluated squamous cell carcinoma antigen (SCC-Ag), cytokeratin 19 fragment (CYFRA 21-1) and C-reactive protein (CRP) simultaneously in oral cavity squamous cell carcinoma (OSCC) patients.

Patients And Methods: Two hundred and forty-six newly diagnosed OSCC patients were retrospectively recruited between December 2010 and December 2016. Read More

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http://dx.doi.org/10.21873/anticanres.13313DOI Listing
April 2019
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HPV Status and Survival in Non-Oropharyngeal Squamous Cell Carcinoma of the Head and Neck.

Anticancer Res 2019 Apr;39(4):1907-1914

Department of Internal Medicine, Division of Oncology-Hematology, VA Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, U.S.A.

Background/aim: HPV-mediated oropharyngeal squamous cell carcinoma is associated with an increased survival. The prognostic value of HPV status for other primary sites is unclear. We aimed to assess the effect of HPV status on overall survival in patients with non-oropharyngeal head and neck squamous cell carcinoma (non-OPSCC) using the National Cancer Database (NCDB). Read More

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http://dx.doi.org/10.21873/anticanres.13299DOI Listing
April 2019
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Validation of gene expression profiles of candidate genes using low density array in peripheral blood of tobacco consuming head and neck cancer patients and auto/taxi drivers with preneoplastic lesions.

Genomics 2019 Apr 2. Epub 2019 Apr 2.

Developmental Toxicology Laboratory, System Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow 226001, U.P., India. Electronic address:

TaqMan Low-Density Array (TLDA) based Real-Time PCR (RT-PCR) of selected genes showed increased expression of polycyclic aromatic hydrocarbons (PAHs) metabolizing cytochrome P450s (CYPs), glutathione S-transferases (GSTs) and associated transcription factors in biopsy and peripheral blood samples isolated from head and neck squamous cell carcinoma (HNSCC) patients when compared to the controls. The genes involved in DNA repair, signal transduction pathway, EMT pathway, apoptosis, and cell adhesion/motility were found to be altered in both peripheral blood and biopsy samples of HNSCC patients. Transcription profiles in blood isolated from auto/taxi drivers, with pre-neoplastic lesions and history of tobacco use, also showed similar alterations. Read More

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http://dx.doi.org/10.1016/j.ygeno.2019.04.003DOI Listing

From presumed benign neck masses to delayed recognition of human papillomavirus-positive oropharyngeal cancer.

Laryngoscope 2019 Apr 5. Epub 2019 Apr 5.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Objectives/hypothesis: To describe patients with delayed diagnosis of human papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV-OPC) after initial incorrect diagnosis of branchial cleft cyst or nondiagnostic workup of unilateral neck mass.

Study Design: Retrospective case series.

Methods: Patients with delayed diagnosis of HPV-OPC after initial nondiagnostic workup for unilateral neck mass were eligible. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/lary.27946
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http://dx.doi.org/10.1002/lary.27946DOI Listing
April 2019
6 Reads

Frozen section is not cost beneficial for the assessment of margins in oral cancer.

Indian J Cancer 2019 Jan-Mar;56(1):19-23

Department of Head and Neck Surgery, Tata Memorial Hospital, Mumbai, Maharashtra, India.

Background: Routine use of frozen section (FS) is a costly procedure and sparsely available in resource poor countries. A proper cost benefit analysis may help to reduce its routine use and would empower surgeons to perform oral cancer surgeries without having FS facility. FS is performed to identify microscopic spread beyond gross disease that cannot be assessed clinically. Read More

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http://dx.doi.org/10.4103/ijc.IJC_41_18DOI Listing
April 2019
10 Reads