76,155 results match your criteria Head and Neck Cancer - Squamous Cell Carcinoma


Lymphotoxin-α promotes tumor angiogenesis in HNSCC by modulating glycolysis in a PFKFB3 dependent manner.

Int J Cancer 2019 Feb 20. Epub 2019 Feb 20.

Department of Oral and Maxillofacial Surgery, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.

Tumor angiogenesis is critical for tumor progression as the new blood vessels supply nutrients and facilitate metastasis. Previous studies indicate tumor associated lymphocytes, including B cells and T cells, contribute to tumor angiogenesis and tumor progression. The present study aims to identify the function of Lymphotoxin-α (LT-α), which is secreted by the activated lymphocytes, in the tumor angiogenesis of head and neck squamous cell carcinoma (HNSCC). Read More

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http://dx.doi.org/10.1002/ijc.32221DOI Listing
February 2019

Cetuximab and Methotrexate in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma- A Single Institution Analysis of 54 Patients.

Clin Otolaryngol 2019 Feb 19. Epub 2019 Feb 19.

Department of Hematology-Oncology and Urology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.

Cetuximab (CTX) and methotrexate (MTX) have both shown single-agent activity in recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) but data on CTX/MTX combination is limited. We report safety and efficacy data of 54 R/M HNSCC patients treated with concurrent CTX/MTX. Median progression-free survival and overall survival were 2. Read More

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http://dx.doi.org/10.1111/coa.13316DOI Listing
February 2019

Specific growth rates calculated from CTs in patients with head and neck squamous cell carcinoma: a retrospective study performed in Austria.

BMJ Open 2019 Feb 19;9(2):e025359. Epub 2019 Feb 19.

Department of Otorhinolaryngology-Head and Neck Surgery, Medical University of Innsbruck, Innsbruck, Austria.

Objective: To provide data on specific growth rates (SGRs) of primary tumours (PT-SGR) and largest pathological cervical lymph nodes (LN-SGR) for head and neck squamous cell carcinoma (HNSCC). To explore PT-SGR's and LN-SGR's correlation with selected biomarkers epidermal growth factor receptor (EGFR), Ki67 and CD44.

Design And Setting: Retrospective study performed at a tertiary oncological referral centre in Innsbruck, Austria. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025359DOI Listing
February 2019

The Emerging Role of Robotic Surgery among Minimally Invasive Surgical Approaches in the Treatment of Hypopharyngeal Carcinoma: Systematic Review and Meta-Analysis.

J Clin Med 2019 Feb 18;8(2). Epub 2019 Feb 18.

Otorhinolaryngology Unit, Humanitas University, Humanitas Clinical and Research Center-IRCCS, 20089 Rozzano, Italy.

The aim of this systematic review with meta-analysis was to investigate the available literature on transoral approaches in the treatment of hypopharyngeal squamous cell carcinoma, with a special focus on transoral robotic surgery (TORS). A systematic review was conducted according to the PRISMA (preferred reporting items for systematic reviews and meta-analyses) check-list, and 15 studies were included. Five of the included studies evaluated TORS, while ten studies focused on transoral laser microsurgery (TLM) for the treatment of early or advanced stage hypopharyngeal cancer. Read More

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http://dx.doi.org/10.3390/jcm8020256DOI Listing
February 2019

Association of Periodontitis with Oral Cancer: A Case-Control Study.

J Dent Res 2019 Feb 19:22034519827565. Epub 2019 Feb 19.

1 Department of Preventive and Social Dentistry, School of Dentistry, Seoul National University, Seoul, Korea.

The association between oral squamous cell carcinoma (OSCC) and periodontitis in large hospital cases with cohort controls has yet to be evaluated. The aim of this study was to investigate the association of periodontitis with OSCC across tumor location and tumor-node-metastasis (TNM) stage among Koreans ( N = 424). OSCC cases ( n = 146) were recruited from Seoul National University Dental Hospital and matched by age, sex, and smoking to controls ( n = 278) from the Yangpyeong health and periodontal cohort in Korea. Read More

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http://dx.doi.org/10.1177/0022034519827565DOI Listing
February 2019

Intraoperative electron beam radiotherapy for locoregionally persistent or recurrent head and neck cancer.

Head Neck 2019 Feb 19. Epub 2019 Feb 19.

Department of Radiation Oncology, Arthur G. James Comprehensive Cancer Center and Richard J. Solove Research Institute, The Ohio State University Medical Center, Columbus, Ohio.

Background: To report our institutional experience with intraoperative radiotherapy for persistent or recurrent head and neck cancer.

Methods: Sixty-one patients were treated with salvage surgery and intraoperative radiation therapy (IORT). Fifty-eight patients (95%) had previously received external beam radiotherapy (EBRT) as a component of their definitive therapy. Read More

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http://dx.doi.org/10.1002/hed.25673DOI Listing
February 2019

Hypopharyngeal cancer treatment: Does initial surgery confer survival benefit?

Head Neck 2019 Feb 19. Epub 2019 Feb 19.

Department of Otolaryngology and Immunology, University of Pittsburgh Medical Center and Cancer Institute, Pittsburgh, Pennsylvania.

Background: Organ preservation protocols have increasingly been applied for the treatment of head and neck cancers, including hypopharyngeal squamous cell carcinoma (HSCC). We sought to evaluate whether patients treated with primary surgery followed by adjuvant therapy had survival benefit over patients treated with initial nonsurgical modalities.

Methods: We retrospectively reviewed patients with new diagnosis of HSCC at the University of Pittsburgh (1994-2014) treated with either primary total laryngectomy with pharyngectomy or organ preservation. Read More

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http://dx.doi.org/10.1002/hed.25687DOI Listing
February 2019

Incidence of second and higher order smoking-related primary cancers following lung cancer: a population-based cohort study.

Thorax 2019 Feb 18. Epub 2019 Feb 18.

Department of Oncology, University of Cambridge, Cambridge, UK.

Background: Lung cancer 5-year survival has doubled over 15 years. Although the risk of second primary cancer is recognised, quantification over time is lacking. We describe the incidence of second and higher order smoking-related primary cancers in lung cancer survivors, identifying high-incidence groups and how incidence changes over time from first diagnosis. Read More

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http://dx.doi.org/10.1136/thoraxjnl-2018-212456DOI Listing
February 2019

Defining optimum surgical margins in buccoalveolar squamous cell carcinoma.

Eur J Surg Oncol 2019 Feb 5. Epub 2019 Feb 5.

Head & Neck Surgery, Tata Memorial Hospital, Mumbai, India. Electronic address:

Introduction: Surgical margin is one of the most important prognostic factors in oral cavity squamous cell carcinoma. There have been studies which refute the standard practice of considering 5 mm (mm) margin as free. Therefore we aimed to evaluate the impact of each mm of margin on the local recurrence free survival (LRFS) and to obtain a cut-off value which would impact the survival the most. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.01.224DOI Listing
February 2019

Impact of human papilloma virus in patients with oral and oropharyngeal squamous cell carcinomas.

Med Clin (Barc) 2019 Mar 7;152(5):174-180. Epub 2018 Jul 7.

Servicio de Anatomía Patológica, Hospital Vall d'Hebron, Barcelona, España.

Background And Objectives: Although there is scientific evidence demonstrating causation of human papilloma virus (HPV) on squamous cell carcinoma of head and neck, its percentage of causality on the anatomic region remains in dispute. This study was developed with the objectives of evaluating the relationship between HPV and oral and oropharyngeal squamous cell carcinomas (OOSCC), and of studying the correlation between HPV detection tests (PCR and p16).

Material And Method: Retrospective study of patients treated for OOSCC during 2011, with a follow-up of 6 years. Read More

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http://dx.doi.org/10.1016/j.medcli.2018.05.015DOI Listing

Histone deacetylase inhibitors suppress aggressiveness of head and neck squamous cell carcinoma via histone acetylation-independent blockade of the EGFR-Arf1 axis.

J Exp Clin Cancer Res 2019 Feb 18;38(1):84. Epub 2019 Feb 18.

Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, 30912, USA.

Background: A promising arsenal of histone deacetylase (HDAC)-targeted treatment has emerged in the past decade, as the abnormal targeting or retention of HDACs to DNA regulatory regions often occurs in many cancers. Head and neck squamous cell carcinoma (HNSCC) is one of the most aggressive malignancies worldwide associated with poor overall survival in late-stage patients. HDAC inhibitors have great potential to treat this devastating disease; however, few has been studied regarding the beneficial role of HDAC inhibition in anti-HNSCC therapy and the underlying molecular mechanisms remain elusive. Read More

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http://dx.doi.org/10.1186/s13046-019-1080-8DOI Listing
February 2019

[Study on the mechanism of miR-497-induced laryngeal squamous cell carcinoma growth inhibition by targeting CDK6].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Feb;54(2):126-132

Department of Otorhinolaryngology Head and Neck Surgery, Second Hospital, Tianjin Medical University, Tianjin 300221, China.

To study the effects of miR-497 and CDK6 on the growth of laryngeal squamous cell carcinoma (LSCC). The expressions of CDK6 mRNA in fresh LSCC specimens, the adjacent normal mucosa of LSCC, and cell lines of LSCC were detected with quantitative real time polymerase chain reaction, pcDNA3.1(+) CDK6 plasmids were respectively transfected into the LSCC cells, and MTT assay and clone formation assay were performed to evaluate the growth of LSCC cells. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.02.006DOI Listing
February 2019

Pravastatin Reverses Established Radiation-Induced Cutaneous and Subcutaneous Fibrosis in Patients with Head and Neck Cancer: Results of the Biology-Driven Phase Ii Clinical Trial Pravacur.

Int J Radiat Oncol Biol Phys 2019 Feb 15. Epub 2019 Feb 15.

Radiation Oncology Department, CHUV Lausanne, Switzerland.

Purpose: The "xxx" phase II trial (NCTxxx) assessed the efficacy of pravastatin as anti-fibrotic agent in patients with established cutaneous and subcutaneous radiation-induced fibrosis (RIF) after head and neck squamous cell carcinoma (HNSCC) radiotherapy and/or radio-chemotherapy.

Methods And Materials: The main inclusion criteria were: patients with HNSCC in remission, with grade ≥2 cutaneous and subcutaneous neck RIF (NCI-CTCAE v4.0); no current treatment with statins or fibrates. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.02.024DOI Listing
February 2019

Impact of American Joint Committee on Cancer Eighth Edition clinical stage and smoking history on oncologic outcomes in human papillomavirus-associated oropharyngeal squamous cell carcinoma.

Head Neck 2019 Feb 18. Epub 2019 Feb 18.

Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.

Background: The purpose of this study was to evaluate the AJCC eighth edition clinical staging system for human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma and to further understand how clinical stage and smoking history affect oncologic outcomes. The purpose of this study was to present the understanding of how clinical stage and smoking history affect oncologic outcomes in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (SCC) is critical for selecting patients for treatment deintensification.

Methods: Kaplan-Meier and Cox regression were used to evaluate overall survival (OS), locoregional recurrence-free survival (LRFS), and distant recurrence-free survival (DRFS). Read More

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http://doi.wiley.com/10.1002/hed.25336
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http://dx.doi.org/10.1002/hed.25336DOI Listing
February 2019
5 Reads

Transoral supraglottic laryngectomy using a next-generation single-port robotic surgical system.

Head Neck 2019 Feb 18. Epub 2019 Feb 18.

Department of Otolaryngology - Head & Neck Surgery, "Regina Elena" National Cancer Institute, Rome, Italy.

Background: To investigate the feasibility of transoral robotic surgery (TORS) supraglottic laryngectomy (SGL) using a next-generation flexible surgical robot.

Methods: Preclinical human cadaver anatomic study of TORS SGL via en bloc resection.

Results: A single-port robotic surgical system (da Vinci Sp, Intuitive Surgical, Inc. Read More

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http://dx.doi.org/10.1002/hed.25676DOI Listing
February 2019

analysis reveals a shared immune signature in -mutated carcinomas with varying correlations to prognosis.

PeerJ 2019 11;7:e6402. Epub 2019 Feb 11.

DeepSeeq Bioinformatics, Bangalore, Karnataka, India.

Background: Sequencing studies across multiple cancers continue to reveal mutations and genes involved in the pathobiology of these cancers. Exome sequencing of oral cancers, a subset of Head and Neck Squamous cell Carcinomas (HNSCs) common among tobacco-chewing populations, revealed that ∼34% of the affected patients harbor mutations in the gene Uterine Corpus Endometrial Carcinoma (UCEC) is another cancer where ∼10% cases harbor mutations. Caspase-8, the protease encoded by gene, plays a dual role in programmed cell death, which in turn has an important role in tumor cell death and drug resistance. Read More

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http://dx.doi.org/10.7717/peerj.6402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375258PMC
February 2019

Impact of postoperative radiation therapy for deeply invasive oral cavity cancer upstaged to stage III.

Head Neck 2019 Feb 18. Epub 2019 Feb 18.

Department of Otolaryngology-Head and Neck Surgery, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Background: This article is about the eighth edition staging guidelines for upstaged patients with oral cavity squamous cell carcinoma (OCSCC) with >10 mm depth to pT3. This upstages some patients from stage I-II to stage III, a point at which patients are traditionally considered for postoperative radiation therapy (PORT). The role of PORT in patients upstaged for >10 mm depth is unknown. Read More

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http://dx.doi.org/10.1002/hed.25498DOI Listing
February 2019

Successful treatment with trastuzumab in HER2-positive squamous cell carcinoma of the head and neck.

Oral Oncol 2019 Feb 14. Epub 2019 Feb 14.

Department of Head and Neck Cancer, Gustave Roussy Cancer Campus, Villejuif, France.

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.008DOI Listing
February 2019

Postoperative Treatment of Oropharyngeal Cancer in the Era of Human Papillomavirus.

Curr Treat Options Oncol 2019 Feb 15;20(3):20. Epub 2019 Feb 15.

Department of Head and Neck Oncologic Surgery, Head and Neck Institute, Cleveland Clinic, 9500 Euclid Avenue, A-71, Cleveland, OH, 44195, USA.

Opinion Statement: Despite an overall decline in the incidence of tobacco-related cancers, human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) of the oropharynx is on the rise. The prognosis of HPV-related oropharynx cancer (HPV-OPC) is generally favorable even in locoregionally advanced disease, and a variety of treatment options are available. Though the primary treatment modality of choice remains definitive radiation (RT), surgical resection followed by appropriate adjuvant therapy remains an option, especially in those patients who may not be favorable candidates for definitive radiotherapy, particularly when concurrent chemotherapy is warranted. Read More

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http://dx.doi.org/10.1007/s11864-019-0620-yDOI Listing
February 2019
1 Read

The stem cell markers expression CD44v6 and podoplanin in lip cancer: clinical significance.

Virchows Arch 2019 Feb 15. Epub 2019 Feb 15.

Department of Surgery, Stomatology, Pathology and Radiology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Alameda Octávio Pinheiro Brisola, 9-75, Bauru, SP, 17012-901, Brazil.

This study aimed to analyze the immunoexpression of cancer stem cell markers, CD44v6, and podoplanin in 91 patients with lip squamous cell carcinomas (LSCC). The immunostaining of podoplanin and CD44v6 was evaluated in ten high-power fields (× 400 magnification) at the invasive front of LSCC, using a semi-quantitative score method. Chi-square test or Fisher's exact test was used to verify the association of podoplanin and CD44v6 expressions with clinicopathologic variables. Read More

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http://dx.doi.org/10.1007/s00428-019-02539-3DOI Listing
February 2019

Prognostic impact of mRNA levels of LGR5 transcript variants in OSCC patients.

BMC Cancer 2019 Feb 15;19(1):155. Epub 2019 Feb 15.

Department of Oral and Maxillofacial Plastic Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str, 40 06097, Halle/Saale, Germany.

Background: The human leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5) is a stem cell marker in numerous adult tissues and is overexpressed in a large number of human carcinoma including colon cancer, breast cancer and oral squamous cell carcinomas (OSCC). The role of the full length transcript (LGR5FL) in progression and prognosis of several cancers was reported. However, the biological function of three splice variants of LGR5 (LGR5Δ5, LGR5Δ8 and LGR5Δ5-8) has yet to be thoroughly investigated. Read More

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http://dx.doi.org/10.1186/s12885-019-5327-8DOI Listing
February 2019
2 Reads

PDK1 mediates NOTCH1-mutated head and neck squamous carcinoma vulnerability to therapeutic PI3K/mTOR inhibition.

Clin Cancer Res 2019 Feb 15. Epub 2019 Feb 15.

Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center

Purpose: Head and neck squamous cell carcinoma (HNSCC) is driven largely by the loss of tumor suppressor genes, including NOTCH1, but lacks a biomarker-driven targeted therapy. Although the PI3K/mTOR pathway is frequently altered in HNSCC, the disease has modest clinical response rates to PI3K/mTOR inhibitors and lacks validated biomarkers of response. We tested the hypothesis that an unbiased pharmacogenomics approach to PI3K/mTOR pathway inhibitors would identify novel, clinically relevant molecular vulnerabilities in HNSCC with loss of tumor suppressor function. Read More

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-3276DOI Listing
February 2019
2 Reads

Application of diffusion-weighted MR imaging with ADC measurement for distinguishing between the histopathological types of sinonasal neoplasms.

Clin Imaging 2019 Feb 7;55:76-82. Epub 2019 Feb 7.

Department of Radiology, University of Minnesota Medical Center, Minneapolis, MN, USA. Electronic address:

Purpose: To evaluate the potential contribution of quantitative DWI parameters including ADC and ADC values to help in distinguishing the histopathological types of sinonasal neoplasms.

Methods: This retrospective study included 83 patients (50 males, 33 females; mean age 61 years) with pathologically proven untreated sinonasal neoplasms who have undergone diffusion-weighted MRI imaging from February 2010 to August 2017. Diffusion-weighted MRI was performed on a 3 T unit with b factors of 0 and 1000 s/mm, and ADC maps were generated. Read More

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http://dx.doi.org/10.1016/j.clinimag.2019.02.004DOI Listing
February 2019

CCL18 promotes the metastasis of squamous cell carcinoma of the head and neck through MTDH-NF-κB signalling pathway.

J Cell Mol Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.

Metastasis is one of the primary causes for high mortality in patients with squamous cell carcinoma of the head and neck (SCCHN). Our previous study showed that chemokine (C-C motif) ligand 18 (CCL18), derived from tumour-associated macrophages (TAMs), regulates SCCHN metastasis by promoting epithelial-mesenchymal transition (EMT) and preserving stemness. However, the underlying mechanism needs to be further investigation. Read More

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http://dx.doi.org/10.1111/jcmm.14168DOI Listing
February 2019

Multicenter Trial of [F]fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Staging of Head and Neck Cancer and Negative Predictive Value and Surgical Impact in the N0 Neck: Results From ACRIN 6685.

J Clin Oncol 2019 Feb 15:JCO1801182. Epub 2019 Feb 15.

10 University of Arkansas for Medical Sciences, Little Rock, AR.

Purpose: The objective of this study was to determine the negative predictive value (NPV) of positron emission tomography (PET)/computed tomography (CT) for the clinically N0 neck on the basis of neck dissection.

Methods: Participants with newly diagnosed, first-time, head and neck squamous cell carcinoma (HNSCC) and at least one clinically N0 neck side for which dissection was planned were included. A total of 287 participants were prospectively enrolled from 23 American College of Radiology Imaging Network-qualified institutions. Read More

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http://dx.doi.org/10.1200/JCO.18.01182DOI Listing
February 2019
1 Read
18.428 Impact Factor

The Relevance of Assessing the Cell Proliferation Factor Ki-67 in Squamous Cell Carcinoma of the Larynx.

Biomed Res Int 2019 15;2019:8142572. Epub 2019 Jan 15.

Department for Otolaryngology and Head and Neck Surgery, Clinical Hospital Center Rijeka, Kresimirova 42, 51000 Rijeka, Croatia.

The aim of study was to investigate the expression of the proliferation factor Ki-67 and its relationship with histological grade, cancer stage, and treatment outcome in squamous cell carcinoma of the larynx. Samples from 78 patients with laryngeal cancer were analysed retrospectively. Paraffin sections of tumors were immunohistochemically stained for Ki-67 expression. Read More

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http://dx.doi.org/10.1155/2019/8142572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350589PMC
January 2019

Safety and efficacy of nimotuzumab with concurrent chemoradiotherapy in unresectable locally advanced squamous cell carcinoma of head and neck: An Indian rural hospital experience.

South Asian J Cancer 2019 Jan-Mar;8(1):52-56

Department of Radiation Oncology, NSCB Medical College and Government Hospital, Jabalpur, Madhya Pradesh, India.

Context: Nimotuzumab is the only anti-epidermal growth factor receptor monoclonal antibody which can be safely added to concurrent chemoradiotherapy (CRT) to improve efficacy in the management of unresectable, locally advanced squamous cell carcinoma of head and neck (LA-SCCHN). However, the evidence available on this is limited.

Aims: We retrospectively investigated efficacy and safety of nimotuzumab when combined with chemoradiation for LA-SCCHN. Read More

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http://dx.doi.org/10.4103/sajc.sajc_76_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348788PMC
February 2019
1 Read

Squamous cell carcinoma of upper alveolus: An experience of a tertiary care center of Northeast India.

South Asian J Cancer 2019 Jan-Mar;8(1):44-46

Department of Gynecologic Oncology, Dr. B Borooah Cancer Institute, Guwahati, Assam, India.

Objective: The main objective of this study was to analyze the clinical behavior and the impact of nodal metastasis on the prognosis of upper alveolus squamous cell carcinoma (SCC).

Materials And Methods: The medical records of 110 patients with SCC of the upper alveolus (International Classification of Diseases-10-C03.0) diagnosed during 2010-2015 were reviewed. Read More

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http://dx.doi.org/10.4103/sajc.sajc_66_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348776PMC
February 2019

Positivity Rates in Oropharyngeal and Nonoropharyngeal Head and Neck Cancer in the VA.

Fed Pract 2018 Aug;35(Suppl 5):S44-S47

and are Attending Physicians; is the Section Chief of the Hematology/Oncology Division; and is the Section Chief of Radiation Oncology, all at Kansas City VAMC in Missouri. is a Nurse Practitioner, and is an Attending Physician, both at the VA Eastern Kansas Health Care System Topeka campus. Dr. Park is a Clinical Assistant Professor, and Dr. Reddy is a Clinical Professor, both in the Department of Radiology at the University of Missouri, Kansas City. Dr. Huang and Dr. Kambhampati are Associate Professors, Medical Oncology at the University of Kansas School of Medicine in Kansas City.

The rates of human papillomavirus positivity of the p16 biomarker in veterans were similar to those of patients with oropharyngeal head and neck tumors in the general population, but differed from general population patients with nonoropharyngeal squamous cell carcinoma. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248148PMC

[The Immune Checkpoints Inhibitors for Head and Neck Cancer].

Authors:
Tomoya Yokota

Gan To Kagaku Ryoho 2019 Jan;46(1):21-27

Division of Gastrointestinal Oncology, Shizuoka Cancer Center.

Recent breakthrough in cancer immunotherapy employing immune checkpoint inhibitors(ICI)has evolved into number of clinical trials with antibodies against PD-1, PD-L1, and CTLA-4 for patients with squamous cell carcinoma of head and neck (SCCHN). The development of ICI in SCCHN initiated in the recurrent and metastatic setting. CheckMate141 supports nivolumab as a standard therapy for patients with platinum-refractory recurrent and metastatic-SCCHN. Read More

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January 2019

Reprogramming of Energy Metabolism in Response to Radiotherapy in Head and Neck Squamous Cell Carcinoma.

Cancers (Basel) 2019 Feb 5;11(2). Epub 2019 Feb 5.

Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología, México/Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, San Fernando No. 22, Col. Sección XVI, Tlalpan, Ciudad de México 14080, México.

Head and neck cancer (HNC) is the sixth cause of cancer-related death worldwide. Head and neck squamous cells carcinoma (HNSCC) is the most frequent subtype of HNC. The development of HNSCC is associated to alcohol consumption, smoking or infection by high-risk human Papillomavirus (HR-HPV). Read More

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http://dx.doi.org/10.3390/cancers11020182DOI Listing
February 2019

The association between human papillomavirus infection and head and neck cancer: A population-based cohort study.

Medicine (Baltimore) 2019 Feb;98(7):e14436

School of Medicine, Chung Shan Medical University.

Human papillomavirus (HPV) has been linked with development of oropharyngeal squamous cell carcinoma, a subset of head and neck cancer (HNC). This study aimed to evaluate the association between HPV infection and subsequent development of HNC and to report epidemiological information in Taiwan.This population-based cohort study retrieved patient data from the longitudinal health insurance database (LHID) of Taiwan's National Health Insurance Research Database (NHIRD) from 2005 to 2010 and analyzed it retrospectively. Read More

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http://dx.doi.org/10.1097/MD.0000000000014436DOI Listing
February 2019
1 Read

Emerging patient-specific treatment modalities in head and neck cancer - a systematic review.

Expert Opin Investig Drugs 2019 Feb 14. Epub 2019 Feb 14.

b Department of Radiation Oncology , University of Lausanne, Centre Hospitalier Universitaire Vaudois (CHUV) , Lausanne , Switzerland.

Introduction: Head and neck cancer (HNC) is an immunosuppressive disease that demonstrates heterogeneous molecular characteristics and features of tumor-host interaction. Beside radiotherapy and surgery, the current standard of care in systemic treatment involves the use of cytotoxic chemotherapy, monoclonal antibodies (mAbs) and tyrosine kinase inhibitors (TKIs). There are also other modalities being developed under the category of immunotherapy, but they are overshadowed by the recent advancements of immune checkpoint inhibitors. Read More

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http://dx.doi.org/10.1080/13543784.2019.1582642DOI Listing
February 2019
1 Read

[Progress in roles and mechanisms of deacetylase SIRT7].

Sheng Wu Gong Cheng Xue Bao 2019 Jan;35(1):13-26

State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China.

As a member of the Sirtuins family in mammals, SIRT7 locates in nucleus and is a highly specific H3K18Ac (acetylated lysine 18 of histone H3) deacetylase. Recent studies showed that SIRT7 could participate in the ribosomal RNA transcription, cell metabolism, cell stress and DNA damage repair through various signaling pathways. In addition, SIRT7 is also closely related with aging, heart disease and fatty liver. Read More

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http://dx.doi.org/10.13345/j.cjb.180139DOI Listing
January 2019
1 Read

Outcomes of carotid-sparing IMRT for T1 glottic cancer: Comparison with conventional radiation.

Laryngoscope 2019 Feb 12. Epub 2019 Feb 12.

Multidisciplinary Larynx Cancer Working Group from the Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, U.S.A.

Objectives: We aim to report oncologic outcomes after conventional radiotherapy (ConRT) using opposed lateral beams and intensity-modulated radiation therapy (IMRT) for tumor (T)1 nodal (N)0 T1 N0 glottic squamous cell carcinoma.

Study Design: Retrospective case-control study.

Methods: We retrospectively reviewed demographic, disease, and treatment characteristics for patients treated at our institution during 2000 to 2013. Read More

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http://dx.doi.org/10.1002/lary.27873DOI Listing
February 2019

Combined Aurora kinase A (AURKA) and WEE1 inhibition demonstrates synergistic antitumor effect in squamous cell carcinoma of the head and neck.

Clin Cancer Res 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Medicine and Yale Cancer Center, Yale University School of Medicine

Purpose: Human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCC) commonly bear disruptive mutations in TP53, resulting in treatment resistance. In these patients, direct targeting of p53 has not been successful, but synthetic lethal approaches have promise. Although Aurora A kinase (AURKA) is overexpressed and an oncogenic driver, its inhibition has only modest clinical effects in HPV-negative HNSCC. Read More

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-18-0440DOI Listing
February 2019
2 Reads
8.722 Impact Factor

Muscle-Specific FXR1 Isoforms in Squamous Cell Cancer.

Trends Cancer 2019 Feb 21;5(2):82-84. Epub 2018 Dec 21.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address:

The RNA-binding protein fragile-X mental retardation autosomal 1 (FXR1) is upregulated in head and neck squamous cell carcinomas (HNSCCs) and expressed as at least seven isoforms in humans. Only two of these isoforms are capable of binding to RNA containing G-quadruplex structures. We suggest that these unique isoforms play a role in the pathogenesis of HNSCC. Read More

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http://dx.doi.org/10.1016/j.trecan.2018.12.001DOI Listing
February 2019

Low let-7d and high miR-205 expression levels positively influence HNSCC patient outcome.

J Biomed Sci 2019 Feb 13;26(1):17. Epub 2019 Feb 13.

Laboratory of Cancer Genetics, Greater Poland Cancer Centre, 15th Garbary Street, room 5025, 61-866, Poznan, Poland.

Introduction: Head and neck squamous carcinoma (HNSCC) is one of the most invasive types of cancer with high mortality. A previous study has indicated that low levels of let-7d and miR-205 in HNSCC patients are correlated with poor survival. Let-7d and miR-205 are tumor suppressors and regulators of epithelial-to-mesenchymal transition (EMT). Read More

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http://dx.doi.org/10.1186/s12929-019-0511-3DOI Listing
February 2019

Investigational multitargeted kinase inhibitors in development for head and neck neoplasms.

Expert Opin Investig Drugs 2019 Feb 12. Epub 2019 Feb 12.

a Department of Otolaryngology - Head and Neck Surgery , University of California , San Francisco , CA 94143 , USA.

Introduction: Despite advances in treatment, head and neck squamous cell carcinoma (HNSCC) survival rates remain stagnant. Current treatment is associated with significant toxicities and includes chemotherapy, radiation, surgery and few targeted treatments. Targeted treatments, epidermal growth factor receptor (EGFR)-targeted agent, cetuximab, and immune checkpoint inhibitors, pembrolizumab and nivolumab, show improved toxicity profiles and modestly improved survival in select patients. Read More

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http://dx.doi.org/10.1080/13543784.2019.1581172DOI Listing
February 2019
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Radiation therapy treatment facility and overall survival in the adjuvant setting for locally advanced head and neck squamous cell carcinoma.

Cancer 2019 Feb 12. Epub 2019 Feb 12.

Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut.

Background: Treatment at high-volume surgical facilities (HVSFs) provides a survival benefit for patients with head and neck squamous cell carcinomas (HNSCCs); however, it is unknown what role postoperative radiation therapy (PORT) plays in achieving the improved outcomes.

Methods: From the National Cancer Database, 6844 patients with locally advanced invasive HNSCCs of the oral cavity, oropharynx, larynx, and hypopharynx who underwent definitive surgery with PORT between 2004 and 2013 were identified. HVSFs were those in the top percentile for annual case volume during this period. Read More

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http://dx.doi.org/10.1002/cncr.32001DOI Listing
February 2019

HPV as a marker for molecular characterization in head and neck oncology: Looking for a standardization of clinical use and of detection method(s) in clinical practice.

Head Neck 2019 Feb 12. Epub 2019 Feb 12.

Infections and Cancer Biology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France.

Background: A consensus about the most appropriate diagnostic method(s) for head and neck human papillomavirus (HPV)-induced carcinogenesis is still lacking because most of the commercially available assays have been designed for the cervix.

Methods: This article summarizes current data and trends concerning HPV diagnostic strategies in oropharyngeal squamous cell carcinoma (OPSCC). Six main approaches are described. Read More

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http://dx.doi.org/10.1002/hed.25591DOI Listing
February 2019
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Barbed suture in oral cavity reconstruction: preliminary results.

Acta Otorhinolaryngol Ital 2019 Jan 31. Epub 2019 Jan 31.

Head and Neck Oncology Service, Oncology Deparment University of Turin, Candiolo Cancer Institute - FPO, IRCCS, Candiolo (To), Italy.

The purpose of this study is to evaluate the efficacy and safety of unidirectional barbed suture (V-Loc) compared to a standard monofilament stitch (Vicryl) in suturing of a free flap to local tissue after head and neck surgery for squamous cell carcinoma of the oral cavity. Complication rates, operative closure time, length of hospitalisation and costs were evaluated. The study cohort (group A) of 20 consecutive patients reconstructed using barbed stitches for suturing was prospectively compared to a control cohort (group B) of 20 consecutive patients reconstructed using conventional vicryl stitches. Read More

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http://dx.doi.org/10.14639/0392-100X-2130DOI Listing
January 2019

Probe-based confocal laser endomicroscopy in detecting malignant lesions of vocal folds.

Acta Otorhinolaryngol Ital 2019 Jan 31. Epub 2019 Jan 31.

Department of Otorhinolaryngology, Head and Neck Surgery, Universität Regensburg, University Hospital, Regensburg, Germany.

Probe-based confocal laser endomicroscopy (CLE) is an innovative technique for real-time, non-invasive analysis of the surface epithelium. While being successfully used for diagnosis by experts, this method has not yet been established in clinical routine, partly due to the lack of standards and criteria for classifying various lesions. Our aim was to determine the diagnostic value and inter-rater reliability of CLE in detecting malignant lesions of the vocal cords. Read More

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http://dx.doi.org/10.14639/0392-100X-2121DOI Listing
January 2019

Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1-2 trial.

Lancet Oncol 2019 Feb 7. Epub 2019 Feb 7.

Department of Oncology, Phase 1 Unit, Rigshospitalet, Copenhagen, Denmark.

Background: Tisotumab vedotin is a first-in-human antibody-drug conjugate directed against tissue factor, which is expressed across multiple solid tumour types and is associated with poor clinical outcomes. We aimed to establish the safety, tolerability, pharmacokinetic profile, and antitumour activity of tisotumab vedotin in a mixed population of patients with locally advanced or metastatic (or both) solid tumours known to express tissue factor.

Methods: InnovaTV 201 is a phase 1-2, open-label, dose-escalation and dose-expansion study done at 21 centres in the USA and Europe. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30859-3DOI Listing
February 2019
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Loss of CD169 Subcapsular Macrophages during Metastatic Spread of Head and Neck Squamous Cell Carcinoma.

Otolaryngol Head Neck Surg 2019 Feb 12:194599819829741. Epub 2019 Feb 12.

1 Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Objective: The purpose of this study is to assess CD169 expression in metastatic and nearby tumor-free lymph nodes of patients with head and neck squamous cell carcinoma (SCC).

Study Design: Retrospective analysis based on immunohistochemistry.

Setting: Tertiary care center. Read More

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http://dx.doi.org/10.1177/0194599819829741DOI Listing
February 2019

Frequent Alteration of Annexin A9 and A10 in HPV-Negative Head and Neck Squamous Cell Carcinomas: Correlation with the Histopathological Differentiation Grade.

J Clin Med 2019 Feb 10;8(2). Epub 2019 Feb 10.

Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias, University of Oviedo, Avda. Roma, 33011, Oviedo, Spain.

The annexin protein superfamily has been implicated in multiple physiological and pathological processes, including carcinogenesis. Altered expression of various annexins has frequently been observed and linked to the development and progression of various human malignancies. However, information is lacking on the expression and clinical significance of annexin A9 (ANXA9) and A10 (ANXA10) in head and neck squamous cell carcinomas (HNSCC). Read More

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http://dx.doi.org/10.3390/jcm8020229DOI Listing
February 2019

The influence of lymph node ratio on survival and disease recurrence in squamous cell carcinoma of the tongue.

Int J Oral Maxillofac Surg 2019 Feb 6. Epub 2019 Feb 6.

Department of Cranio-Maxillo-Facial and Oral Surgery, University Hospital of Zurich, Zurich, Switzerland.

This study was performed to report the outcomes of patients with oral squamous cell carcinoma (OSCC) of the tongue over a 10-year period with the aim of testing the hypothesis that the lymph node ratio (LNR) has a significant influence on loco-regional recurrence. The charts of 227 patients with OSCC of the mobile tongue treated at the University Hospital of Zurich from 2003 to 2012 were screened. Following the application of the exclusion criteria (prior chemotherapy, radiotherapy, or surgery, perioperative death, N3 disease, unresectable disease, synchronous second primary, no signed informed consent, and follow-up <3years), prospective data were collected and a retrospective analysis performed for 88 of these patients who were treated with selective neck dissection. Read More

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http://dx.doi.org/10.1016/j.ijom.2019.01.008DOI Listing
February 2019
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Cytoplasmic HMGB1 and HMGB1-Beclin1 complex are increased in radioresistant oral squamous cell carcinoma.

Br J Oral Maxillofac Surg 2019 Feb 6. Epub 2019 Feb 6.

Department of Otorhinolaryngology - Head and Neck Surgery, College of Medicine, Chung-Ang University, Seoul, Republic of Korea. Electronic address:

Cytoplasmic high mobility group box 1 (HMGB1) is an autophagy regulator, and autophagy is important in the radioresistance of various solid cancers. We evaluated the degree of autophagy and cytoplasmic HMGB1 in radioresistant oral squamous cell carcinoma (SCC) by culturing the SCC15 and quasiliquid layer 1 (QLL1) SCC cell lines that originate from cancer of the oral tongue and a metastatic lymph node, respectively, and then delivered radiation to induce radioresistance to cells. We then compared the degree of autophagy between non-irradiated control and radioresistant cancer cells using a western blot assay. Read More

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http://dx.doi.org/10.1016/j.bjoms.2019.01.011DOI Listing
February 2019

The role of age in treatment-related adverse events in patients with head and neck cancer: A systematic review.

Head Neck 2019 Feb 9. Epub 2019 Feb 9.

International Head and Neck Scientific Group, Padua, Italy.

Head and neck squamous cell carcinoma (HNSCC) is often diagnosed in advanced stage and therefore requires aggressive, multimodal treatment. Elderly patients are often excluded from standard therapy regimens purely based on age. This clinical review aims to collect all published data in the literature on treatment modality selection in elderly patients and on age-related adverse events following treatment of HNSCC. Read More

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http://dx.doi.org/10.1002/hed.25696DOI Listing
February 2019

Examining adjuvant radiation dose in head and neck squamous cell carcinoma.

Head Neck 2019 Feb 9. Epub 2019 Feb 9.

Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.

Background: Compare adjuvant radiation dose trends and outcomes in head and neck squamous cell carcinoma (HNSCC).

Methods: Nonmetastatic HNSCCs treated between 2004 and 2014 with primary site surgery, lymph node dissection, and adjuvant radiation were identified in the National Cancer Database. Standard dose radiation (SD-RT) was defined as an equivalent dose in 2 Gy (EQD2) ≥56. Read More

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http://dx.doi.org/10.1002/hed.25680DOI Listing
February 2019
1 Read