82,008 results match your criteria Head and Neck Cancer - Squamous Cell Carcinoma


Salvage surgery in head and neck cancer: External validation of predictors of disease-specific survival.

Oral Oncol 2020 Jun 29;109:104876. Epub 2020 Jun 29.

Department of Otolaryngology-Head and Neck Surgery, University Hospital de la Santa Creu i Sant Pau, Universitat Autonòma de Barcelona, Barcelona, Spain.

Objective: Salvage surgery in recurrent head and neck squamous cell carcinoma (HNSCC) is associated with poor outcomes. There is great interest to better identify suitable surgical patients. This study aimed to validate the proposal of Hamoir et al. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104876DOI Listing

Treatment implications of postoperative chemoradiotherapy for squamous cell carcinoma of the oral cavity with minor and major extranodal extension.

Oral Oncol 2020 Jun 29;110:104845. Epub 2020 Jun 29.

Department of Pathology, University Health Network, Toronto, Canada.

Objectives: To evaluate adjuvant chemoradiotherapy (CRT) for patients with oral cavity squamous cell carcinoma (OSCC) with minor or major extranodal extension (ENE).

Materials And Methods: Surgically resected OSCC with pathologically involved lymph node(s) (pN+) between 2006 and 2017. Sections of pN+ were re-reviewed and classified as no, minor (≤2 mm), or major (>2 mm) ENE. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104845DOI Listing

[Prognostic and predictive methylation biomarkers in HNSCC : Epigenomic diagnostics for head and neck squamous cell carcinoma (HNSCC)].

HNO 2020 Jul 1. Epub 2020 Jul 1.

Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde, Universitätsklinikum Bonn, Venusberg-Campus 1, 53127, Bonn, Deutschland.

Background: Prognostic and predictive biomarkers for personalized treatment management in head and neck squamous cell carcinoma (HNSCC) are of great clinical interest.

Objective: DNA methylation is an epigenetic process involved in gene regulation and could be a source of potential prognostic and predictive biomarkers.

Methods: This study comprises literature research in PubMed and own studies. Read More

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http://dx.doi.org/10.1007/s00106-020-00902-4DOI Listing

The radiobiology of HPV-positive and HPV-negative head and neck squamous cell carcinoma.

Expert Rev Mol Med 2020 Jul 2;22:e3. Epub 2020 Jul 2.

Cancer Research Centre, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, 200 London Road, LiverpoolL3 9TA, UK.

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, with reported incidences of ~800 000 cases each year. One of the critical determinants in patient response to radiotherapy, particularly for oropharyngeal cancers, is human papillomavirus (HPV) status where HPV-positive patients display improved survival rates and outcomes particularly because of increased responsiveness to radiotherapy. The increased radiosensitivity of HPV-positive HNSCC has been largely linked with defects in the signalling and repair of DNA double-strand breaks. Read More

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http://dx.doi.org/10.1017/erm.2020.4DOI Listing

Occult Metastasis in Laryngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.

Ann Otol Rhinol Laryngol 2020 Jul 1:3489420937744. Epub 2020 Jul 1.

Department of Otolaryngology-Head and Neck Surgery, Medical College of Georgia at Augusta University, Augusta, GA, USA.

Objective: The incidence of occult metastasis (OM) in laryngeal squamous cell carcinoma (SCC) is still widely debated. In this systematic review, we aim to determine the rate of OM in laryngeal SCC, its impact on recurrence, and the role of elective neck dissection (END) in the management of the clinically negative neck.

Methods: A systematic review of the English-language literature in Web of Science, PubMed, MEDLINE, and Cochrane Library databases on occult metastasis in laryngeal SCC from 1977 to 2018 was conducted. Read More

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http://dx.doi.org/10.1177/0003489420937744DOI Listing

A Novel Tumor Suppressor SPINK5 Serves as an Independent Prognostic Predictor for Patients with Head and Neck Squamous Cell Carcinoma.

Cancer Manag Res 2020 23;12:4855-4869. Epub 2020 Jun 23.

Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Background: In our previous study, serine protease inhibitor Kazal-type 5 (SPINK5), which encodes the product of serine protease inhibitor lymphoepithelial Kazal-type-related inhibitor (LEKTI) was found to be down-regulated in head and neck squamous cell carcinoma (HNSCC) using oligonucleotide microarrays. However, the function and clinical implications of SPINK5/LEKTI remain obscure in HNSCC.

Methods: The endogenous expression level of SPINK5/LEKTI was further verified in 9 HNSCC cell lines and HNSCCs by means of reverse transcription-polymerase chain reaction, real-time PCR, Western blotting and immunohistochemistry. Read More

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http://dx.doi.org/10.2147/CMAR.S236266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320891PMC

Effect of CXCR5-Positive Cell Infiltration on the Immune Contexture and Patient Prognosis in Head and Neck Squamous Cell Carcinoma.

Onco Targets Ther 2020 22;13:5869-5877. Epub 2020 Jun 22.

Bone and Joint Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.

Purpose: CXCR5-positive (CXCR5) tumor cell infiltration has different prognostic values in different types of cancer. The objective was to evaluate the effect of CXCR5 cell infiltration in head and neck squamous cell carcinoma (HNSCC).

Patients And Methods: The study included two patient cohorts: The Cancer Genome Atlas cohort (TCGA, n = 472) and the Renji Hospital cohort (RJHC, n = 201). Read More

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http://dx.doi.org/10.2147/OTT.S248958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319516PMC

Intracardiac metastasis from head and neck squamous cell carcinoma.

BMJ Case Rep 2020 Jun 30;13(6). Epub 2020 Jun 30.

Department of Hematology/Medical Oncology, University of Missouri System, Columbia, Missouri, USA.

Cardiac metastasis from head and neck cancer is an extremely rare and devastating condition with an abysmal prognosis. Most of our knowledge about this condition is from case reports and series. We present a case of squamous cell carcinoma of the tonsils that was complicated by embolic stroke and critical limb ischemia that were found to be secondary to intracardiac metastasis. Read More

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http://dx.doi.org/10.1136/bcr-2020-234691DOI Listing

Repurposing the FDA-Approved Antiviral Drug Ribavirin as Targeted Therapy for Nasopharyngeal Carcinoma.

Mol Cancer Ther 2020 Jun 30. Epub 2020 Jun 30.

Hunterian Neurosurgical Research Laboratory, Department of Neurosurgery, Johns Hopkins University School of Medicine

Nasopharyngeal carcinoma (NPC) is a squamous cell carcinoma with a proclivity for systemic dissemination, leading many patients to present with advanced-stage disease and fail available treatments. There is a notable lack of targeted therapies for NPC, despite working knowledge of multiple proteins with integral roles in NPC cancer biology. These proteins include EZH2, Snail, eIF4E, and IMPDH, which are all overexpressed in NPC and correlated with poor prognosis. Read More

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http://dx.doi.org/10.1158/1535-7163.MCT-19-0572DOI Listing

Index of Cancer-Associated Fibroblasts Is Superior to the Epithelial-Mesenchymal Transition Score in Prognosis Prediction.

Cancers (Basel) 2020 Jun 28;12(7). Epub 2020 Jun 28.

National Institute of Cancer Research, National Health Research Institutes, Miaoli County 35053, Taiwan.

In many solid tumors, tissue of the mesenchymal subtype is frequently associated with epithelial-mesenchymal transition (EMT), strong stromal infiltration, and poor prognosis. Emerging evidence from tumor ecosystem studies has revealed that the two main components of tumor stroma, namely, infiltrated immune cells and cancer-associated fibroblasts (CAFs), also express certain typical EMT genes and are not distinguishable from intrinsic tumor EMT, where bulk tissue is concerned. Transcriptomic analysis of xenograft tissues provides a unique advantage in dissecting genes of tumor (human) or stroma (murine) origins. Read More

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http://dx.doi.org/10.3390/cancers12071718DOI Listing

The Intermediate Filament Synemin Regulates Non-Homologous End Joining in an ATM-Dependent Manner.

Cancers (Basel) 2020 Jun 28;12(7). Epub 2020 Jun 28.

OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.

The treatment resistance of cancer cells is a multifaceted process in which DNA repair emerged as a potential therapeutic target. DNA repair is predominantly conducted by nuclear events; yet, how extra-nuclear cues impact the DNA damage response is largely unknown. Here, using a high-throughput RNAi-based screen in three-dimensionally-grown cell cultures of head and neck squamous cell carcinoma (HNSCC), we identified novel focal adhesion proteins controlling DNA repair, including the intermediate filament protein, synemin. Read More

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http://dx.doi.org/10.3390/cancers12071717DOI Listing

The Value of Laboratory Parameters for Anemia, Renal Function, Systemic Inflammation and Nutritional Status as Predictors for Outcome in Elderly Patients with Head-and-Neck Cancers.

Cancers (Basel) 2020 Jun 26;12(6). Epub 2020 Jun 26.

Department of Radiation Oncology, University of Freiburg-Medical Center, Robert-Koch-Str. 3, 79106 Freiburg, Germany.

The purpose of this study was to evaluate the value of routine blood markers regarding their predictive potential for treatment outcomes of elderly head-and-neck squamous cell carcinoma (HNSCC) patients. In total, 246 elderly HNSCC patients (≥65 years) undergoing (chemo)radiotherapy from 2010 to 2018 were analyzed for treatment outcomes, depending on their hemoglobin, glomerular filtration rate (GFR), C-reactive protein (CRP) and albumin values, representing anemia, kidney function, inflammation and nutrition status, respectively. Local/locoregional control, progression-free and overall survival (OS) were calculated using the Kaplan-Meier method. Read More

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http://dx.doi.org/10.3390/cancers12061698DOI Listing

Radiation-induced second primary squamous cell carcinoma of the oral cavity after radiotherapy for nasopharyngeal carcinoma.

Oral Oncol 2020 Jun 27;109:104863. Epub 2020 Jun 27.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, PR China. Electronic address:

Background: The increasing occurrence of radiation-induced second primary squamous cell carcinoma of the oral cavity (RISCCO) after radiotherapy for nasopharyngeal carcinoma (NPC) has become a noteworthy complication that can influence long-term survival. This study aimed to analyze the associations of clinicopathologic characteristics with prognostic factors among patients who developed RISCCO after radiotherapy for NPC.

Methods: A total of 41,446 NPC patients admitted to Sun Yat-sen University Cancer Center (SYSUCC) between August 1989 and January 2019 were reviewed. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104863DOI Listing

A novel technique of arterial blood flow modification in intra-arterial chemoradiotherapy of maxillary sinus squamous cell carcinoma.

Oral Oncol 2020 Jun 27;109:104873. Epub 2020 Jun 27.

Department of Head and Neck Oncology and Surgery, International University of Health and Welfare, Mita Hospital, 1-4-3 Mita, Minato-ku, Tokyo 108-8329, Japan. Electronic address:

Objectives: Intra-arterial chemoradiotherapy via a superficial temporal artery is reportedly a useful organ-preserving treatment for maxillary sinus squamous cell carcinoma. This study aimed to determine whether blood flow modification facilitates sufficient drug delivery to the entire carcinoma via the maxillary artery alone, even for advanced tumors.

Materials And Methods: A retrospective study of 10 patients who were diagnosed with locally advanced carcinoma (4 [40%] at stage T3, 5 [50%] at T4a, and 1 [10%] at T4b) from August 2016 to July 2018, with tumor blood flow from both the maxillary and facial arteries, was conducted. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104873DOI Listing

Association of Nonsteroidal Anti-inflammatory Drug Use With Survival in Patients With Squamous Cell Carcinoma of the Head and Neck Treated With Chemoradiation Therapy.

JAMA Netw Open 2020 Jun 1;3(6):e207199. Epub 2020 Jun 1.

Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York.

Importance: Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin, are commonly prescribed medications with anti-inflammatory and antiplatelet properties used long term to decrease the risk of cardiovascular events. A recent study showed that aspirin was associated with improved survival in patients with head and neck squamous cell carcinoma (HNSCC) who were treated with surgery.

Objective: To examine whether use of NSAIDs during definitive chemoradiation therapy (CRT) was associated with improved outcomes in patients with HNSCC. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.7199DOI Listing

The Immune Microenvironment in Head and Neck Squamous Cell Carcinoma: on Subsets and Subsites.

Curr Oncol Rep 2020 Jun 29;22(8):81. Epub 2020 Jun 29.

Department of Otolaryngology-Head and Neck Surgery, Cancer Center Amsterdam, Amsterdam UMC, VU University medical center, De Boelelaan, 1117, Amsterdam, The Netherlands.

Purpose: To understand why some patients respond to immunotherapy but many do not, a clear picture of the tumor microenvironment (TME) of head and neck squamous cell carcinoma (HNSCC) is key. Here we review the current understanding on the immune composition per HNSCC subsite, the importance of the tumor's etiology and the prognostic power of specific immune cells.

Recent Findings: Large cohort data are mostly based on deconvolution of transcriptional databases. Read More

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http://dx.doi.org/10.1007/s11912-020-00938-3DOI Listing

An Update on Surgical Margins in the Head Neck Squamous Cell Carcinoma: Assessment, Clinical Outcome, and Future Directions.

Curr Oncol Rep 2020 Jun 30;22(8):82. Epub 2020 Jun 30.

Head and Neck Oncology Department, Tata Memorial Hospital and HBNI, Mumbai, India.

Purpose Of Review: Failure to achieve tumor-free margins is the single largest cause of death for head neck cancer patients. At the same time, it is the only factor that is in complete control of the surgeon. This review summarizes evidence for the definition, clinical implications, and methods to achieve optimal margins. Read More

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http://dx.doi.org/10.1007/s11912-020-00942-7DOI Listing

Dual Energy Computed Tomography in Head and Neck Imaging: Pushing the Envelope.

Neuroimaging Clin N Am 2020 Aug 10;30(3):311-323. Epub 2020 Jun 10.

Augmented Intelligence & Precision Health Laboratory, Department of Radiology, Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec H4A 3J1, Canada; Department of Radiology, McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada; Segal Cancer Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote Suite-Catherine Road, Montreal, Quebec H3T 1E2, Canada; Gerald Bronfman Department of Oncology, McGill University, Suite 720, 5100 Maisonneuve Boulevard West, Montreal, Quebec H4A3T2, Canada; Department of Otolaryngology, Head and Neck Surgery, Royal Victoria Hospital, McGill University Health Centre, 1001 boul. Decarie Boulevard, Montreal, Quebec H3A 3J1, Canada. Electronic address:

Multiple applications of dual energy computed tomography (DECT) have been described for the evaluation of disorders in the head and neck, especially in oncology. We review the body of evidence suggesting advantages of DECT for the evaluation of the neck compared with conventional single energy computed tomography scans, but the full potential of DECT is still to be realized. There is early evidence suggesting significant advantages of DECT for the extraction of quantitative biomarkers using radiomics and machine learning, representing a new horizon that may enable this technology to reach its full potential. Read More

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http://dx.doi.org/10.1016/j.nic.2020.04.003DOI Listing

MAGE-A4, NY-ESO-1 and SAGE mRNA expression rates and co-expression relationships in solid tumours.

BMC Cancer 2020 Jun 29;20(1):606. Epub 2020 Jun 29.

Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

Background: Cancer testis (CT) antigens are promising targets for cancer immunotherapies such as cancer vaccines and genetically modified adoptive T cell therapy. In this study, we evaluated the expression of three CT antigens, melanoma-associated antigen A4 (MAGE-A4), New York oesophageal squamous cell carcinoma 1 (NY-ESO-1) and sarcoma antigen gene (SAGE).

Methods: MAGE-A4, NY-ESO-1 and/or SAGE antigen expression in tumour samples was evaluated by quantitative real-time polymerase chain reaction (qRT-PCR). Read More

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http://dx.doi.org/10.1186/s12885-020-07098-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325278PMC

Machine Learning Prediction of Extracapsular Extension in Human Papillomavirus-Associated Oropharyngeal Squamous Cell Carcinoma.

Otolaryngol Head Neck Surg 2020 Jun 30:194599820935446. Epub 2020 Jun 30.

Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, University of Maryland, Baltimore, Maryland, USA.

Objective: To determine whether machine learning (ML) can predict the presence of extracapsular extension (ECE) prior to treatment, using common oncologic variables, in patients with human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC).

Study Design: Retrospective database review.

Setting: National Cancer Database study. Read More

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http://dx.doi.org/10.1177/0194599820935446DOI Listing

Sinonasal Squamous Cell Carcinoma Outcomes: Does Treatment at a High-Volume Center Confer Survival Benefit?

Otolaryngol Head Neck Surg 2020 Jun 30:194599820935395. Epub 2020 Jun 30.

Division of Rhinology and Skull Base Surgery, Department of Head and Neck Surgery and Communication Sciences, Duke University Health System, Durham, North Carolina, USA.

Objective: To determine whether treatment of sinonasal squamous cell carcinoma (SCC) at a high-volume facility affects survival.

Study Design: Retrospective database analysis.

Setting: National Cancer Database (2004-2014). Read More

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http://dx.doi.org/10.1177/0194599820935395DOI Listing

Feasibility of In-office Fine-Needle Aspiration for Base of Tongue Tumors.

Otolaryngol Head Neck Surg 2020 Jun 30:194599820935454. Epub 2020 Jun 30.

Department of Otolaryngology, University of Vermont Medical Center, Burlington, Vermont, USA.

We aim to demonstrate the feasibility of in-office transcervical ultrasound (TCUS)-guided fine-needle aspiration (FNA) of base of tongue (BOT) tumors in a single-institution. Retrospective chart review was performed and 3 patients met criteria, with BOT tumors ≥3 cm . Two patients had no cervical adenopathy, while FNA of a cervical lymph node was inconclusive in patient 3. Read More

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http://dx.doi.org/10.1177/0194599820935454DOI Listing

Glycoprotein Nonmetastatic Melanoma Protein B as Potential Imaging Marker in Posttherapeutic Metastatic Head and Neck Cancer.

Otolaryngol Head Neck Surg 2020 Jun 30:194599820932869. Epub 2020 Jun 30.

Department of Otorhinolaryngology, Head and Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Objective: To evaluate expression of potential molecular imaging targets epidermal growth factor receptor (EGFR), glycoprotein nonmetastatic melanoma protein B (GPNMB), and vascular endothelial growth factor (VEGF) in lymph nodes (LNs) with or without head and neck squamous cell carcinoma (HNSCC) metastases after (chemo)radiation.

Study Design: Retrospective study comparing receptor expression in paired lymph nodes after initial treatment.

Setting: A tertiary referral hospital. Read More

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http://dx.doi.org/10.1177/0194599820932869DOI Listing

Acquisition of Cisplatin Resistance Shifts Head and Neck Squamous Cell Carcinoma Metabolism toward Neutralization of Oxidative Stress.

Cancers (Basel) 2020 Jun 24;12(6). Epub 2020 Jun 24.

Bobby R. Alford Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Houston, TX 77030, USA.

: Cisplatin (CDDP) is commonly utilized in the treatment of advanced solid tumors including head and neck squamous cell carcinoma (HNSCC). Cisplatin response remains highly variable among individual tumors and development of cisplatin resistance is common. We hypothesized that development of cisplatin resistance is partially driven by metabolic reprogramming. Read More

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http://dx.doi.org/10.3390/cancers12061670DOI Listing

HCV infection and the risk of head and neck cancer: A meta-analysis.

Oral Oncol 2020 Jun 26;109:104869. Epub 2020 Jun 26.

Department of Neurosciences, Section of Otolaryngology, University of Padova, Treviso, Italy. Electronic address:

Recent evidence has consistently suggested a role for HCV in the etiology of head and neck squamous cell carcinoma (HNSCC), but the conclusions of these studies have often been limited by small sample size. Therefore, a meta-analysis was performed to summarize present evidence on the association between HCV infection and HNSCC. After screening citations from literature search, eight observational studies investigating the association between HCV and cancer(s) of either oral cavity, oropharynx, hypopharynx or larynx were included. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104869DOI Listing

Nonsurgical management of resectable oral cavity cancer in the wake of COVID-19: A rapid review and meta-analysis.

Oral Oncol 2020 Jun 10;109:104849. Epub 2020 Jun 10.

Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada; Department of Otolaryngology - Head and Neck Surgery, University of Toronto, Toronto, Canada. Electronic address:

Objective: Surgery is the preferred treatment modality for oral squamous cell carcinoma (OSCC). However, due to limited resources, re-assessment of treatment paradigms in the wake of the Coronavirus Disease 2019 (COVID-19) pandemic is urgently required. In this rapid review, we described contemporary oncological outcomes for OSCC using non-surgical modalities. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284253PMC

Oral cancer: The first symptoms and reasons for delaying correct diagnosis and appropriate treatment.

Adv Clin Exp Med 2020 Jun;29(6):735-743

Department of Maxillofacial Surgery, Wroclaw Medical University Hospital, Poland.

Background: The first symptoms of oral cancer are nonspecific. They raise suspicions of other, less serious conditions. Treatment of oral cancer is challenging, and the time of its detection and the implementation of appropriate therapy affect the prognosis. Read More

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http://dx.doi.org/10.17219/acem/116753DOI Listing

Integrated Bioinformatics Analysis of mRNAs and miRNAs Identified Potential Biomarkers of Oral Squamous Cell Carcinoma.

Asian Pac J Cancer Prev 2020 Jun 29;21(6):1841-1848. Epub 2020 Jun 29.

Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran.

Background: Oral cancer is a frequently encountered neoplasm of the head and neck region, being the eighth most common type of human malignancy worldwide. Despite improvement in its control, morbidity and mortality, rates have improved little in the past decades. The present investigations about gene interaction and pathways still could not clear the appearance and development of oral squamous cell carcinoma (OSCC), completely. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1841DOI Listing

Predictors of nodal metastasis in sinonasal squamous cell carcinoma: A national cancer database analysis.

World J Otorhinolaryngol Head Neck Surg 2020 Jun 25;6(2):137-141. Epub 2020 Mar 25.

Department of Otorhinolaryngology - Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, United States.

Objective: We present the largest population based study of sinonasal squamous cell carcinoma (SCC) to identify risk factors for presentation with nodal metastasis.

Methods: The National Cancer Database (NCDB) was used for this study. Location codes corresponding to the nasal cavity and paranasal sinuses and histology codes representing SCC malignancy were queried. Read More

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http://dx.doi.org/10.1016/j.wjorl.2020.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296471PMC

Predictors of chemotherapy and its effects in early stage squamous cell carcinoma of the larynx.

Laryngoscope Investig Otolaryngol 2020 Jun 24;5(3):445-452. Epub 2019 Dec 24.

Division of Radiation Oncology Allegheny Health Network Cancer Institute, Allegheny General Hospital Pittsburgh PA.

Background: Squamous cell carcinoma (SCC) of larynx is a common head and neck cancer. For cases that are node negative, the role of definitive concurrent chemoradiation is unclear and not supported by guidelines but used at provider discretion. To address this knowledge gap, we examined the oncological outcomes with additional chemotherapy and factors correlated with the chemotherapy administration. Read More

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http://dx.doi.org/10.1002/lio2.327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314463PMC

Acupuncture Therapy in Post-Radiation Head-and-Neck Cancer with Dysgeusia.

Med Acupunct 2020 Jun 16;32(3):157-162. Epub 2020 Jun 16.

Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Jakarta, Indonesia.

Radiation therapy for head-and-neck cancer can cause side-effects, including pain, nausea, vomiting, sensory disorders such as anosmia and dysgeusia, dysphagia, xerostomia, hot flashes, fatigue, sleep disorders, and even anxiety and depression disorders. Therapies using acupuncture are now being adopted at cancer therapy centers. Acupuncture has been clinically proven to reduce the side-effects of cancer therapies, thus, resulting in better quality of life. Read More

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http://dx.doi.org/10.1089/acu.2020.1410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310235PMC

Chrysophanol Regulates Cell Death, Metastasis, and Reactive Oxygen Species Production in Oral Cancer Cell Lines.

Evid Based Complement Alternat Med 2020 26;2020:5867064. Epub 2020 May 26.

National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Miaoli County, Taiwan, China.

Background: Oral cancer belongs to the class of head and neck cancers and can be life threatening if not diagnosed and treated early. Activation of cell death via apoptosis or reactive oxygen species (ROS) accumulation and inhibition of cell cycle progression, migration, and epithelial-to-mesenchymal transition (EMT) may be a good strategy to arrest the development of oral cancer. In this study, we analyzed the possible action of chrysophanol isolated from the rhizomes of on the oral cancer cell lines FaDu (human pharynx squamous cell carcinoma) and SAS (human tongue squamous carcinoma) by investigating whether chrysophanol could influence cell death. Read More

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http://dx.doi.org/10.1155/2020/5867064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271060PMC

POSITIVE EXPRESSION OF NEDD9 IN HEAD AND NECK CANCER IS RELATED TO BETTER SURVIVAL PERIOD.

Acta Clin Croat 2019 Dec;58(4):655-661

1Division of Head and Neck Surgery, Department of Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 2Department of Otorhinolaryngology and Head and Neck Surgery, Zagreb University Hospital Centre, Zagreb, Croatia; 3Department of Pathology, University Hospital for Tumors, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 4Department of Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia.

The aim was to determine immunohistochemical expression of NEDD9 protein in head and neck squamous cell carcinoma (HNSCC) and the possible relation of its expression with primary tumor size (T), regional lymph node status (N), stage of disease (TNM) and survival period. A total of 131 patients with primary tumor localization in the area of oropharynx, hypopharynx and larynx, monitored for at least 5 years after initial surgical treatment were analyzed. The study included 128 male and three female patients, median age 62. Read More

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http://dx.doi.org/10.20471/acc.2019.58.04.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314307PMC
December 2019

Robot-assisted real-time sentinel lymph node mapping in oral cavity cancer: preliminary experience.

J Robot Surg 2020 Jun 27. Epub 2020 Jun 27.

Division of Head and Neck Surgery, Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China.

This study aims to assess the feasibility of using indocyanine green and robotic near infra-red fluorescent imaging (Firefly) for sentinel lymph node biopsy in cN0 oral cavity cancer. Ten patients with early squamous cell carcinoma of the tongue (n = 8) and buccal mucosa (n = 2) were included. Peritumoral injection of 10 mg indocyanine green and real-time mapping of sentinel lymph nodes in the neck was performed using Firefly via a retro-auricular trans-hairline incision. Read More

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http://dx.doi.org/10.1007/s11701-020-01112-4DOI Listing

Virtual screening of mutations in antioxidant genes and its putative association with HNSCC: An in silico approach.

Mutat Res 2020 Jun 9;821:111710. Epub 2020 Jun 9.

Biomedical Research Unit and Laboratory Animal Centre (BRULAC) - Dental Research Cell (DRC), Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Poonamallee High Road, Chennai 600 077, Tamil Nadu, India.

Abnormalities in the antioxidant pathway are usually associated with inflammatory conditions, followed by tissue damage. Cancer is one such disease where there is a build-up of reactive oxygen species leading to pathological consequences. The present study aims to identify the alteration in genes and proteins associated with the common antioxidant pathways among patients with head and neck squamous cell carcinoma (HNSCC). Read More

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http://dx.doi.org/10.1016/j.mrfmmm.2020.111710DOI Listing

Characteristics and Impact of HPV-Associated p16 Expression on Head and Neck Squamous Cell Carcinoma in Thai Patients.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1679-1687. Epub 2020 Jun 1.

Division of Medical Oncology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: Head and neck squamous cell carcinoma (HNSCC) is a common malignancy in Asia. Infection by human papilloma virus (HPV) has been recognized as an etiological risk for HNSCC, especially oropharyngeal region. While the association between HPV and HNSCC has been well evaluated in Western countries, only a few investigated the HPV-associated HNSCC in Southeast Asia. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1679DOI Listing

Glutathione S-transferase Polymorphisms in Head and Neck Squamous Cell Carcinoma Treated with Chemotherapy and/or Radiotherapy.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1637-1644. Epub 2020 Jun 1.

Department of Molecular Biological, Genetics and Molecular Biology Research Unit - UPGEM, Faculty of Medicine of São José do Rio Preto - FAMERP, São José do Rio Preto, São Paulo, Brazil.

Background/aim: The Glutathione S-transferases (GSTs) are important carcinogen-metabolizing enzymes. Polymorphisms involved in these enzymes can modulate the development and treatment of head and neck cancer. To investigate the association of GSTs polymorphisms with head and neck cancer and risk factors, clinical-pathological features, and survival time of the patients treated with chemotherapy and/or radiotherapy. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.6.1637DOI Listing

Neutrophil-to-lymphocyte ratio as a prognostic indicator for overall and cancer-specific survival in squamous cell carcinoma of the head and neck.

Head Neck 2020 Jun 27. Epub 2020 Jun 27.

Department of Medicine, Division of General Internal Medicine, Mount Sinai Hospital, New York, New York, USA.

Background: Neutrophil-to-lymphocyte ratio (NLR) is a biomarker that is correlated with systemic inflammation and poor prognosis in solid tumors. We investigated the value of NLR in predicting survival in a large population of head and neck cancer patients in the United States.

Methods: We performed a retrospective cohort study of Veterans Affairs patients with head and neck squamous cell carcinoma (HNSCC) diagnosed between January 2000 and December 2017. Read More

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http://dx.doi.org/10.1002/hed.26329DOI Listing

What is the impact of COVID-19 on head and neck squamous cell carcinoma patients?

Authors:
Sean Dolan

Evid Based Dent 2020 06;21(2):52-53

DCT2, Oral and Maxillofacial Surgery, Ninewells Hospital, Dundee, UK.

Data sources It is not made clear in this review the different databases selected or how they conducted their search. The studies used are from 1975-2020Study selection The authors have performed a scoping review using 84 studies ranging from 1975-2020. The majority of these are from before the 2019-2020 COVID-19 outbreak period. Read More

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http://dx.doi.org/10.1038/s41432-020-0091-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317258PMC

Analysis of real-world PD-L1 IHC 28-8 and 22C3 pharmDx assay utilisation, turnaround times and analytical concordance across multiple tumour types.

J Clin Pathol 2020 Jun 26. Epub 2020 Jun 26.

Bristol Myers Squibb, Princeton, New Jersey, USA.

Aims: Programmed death-1/programmed death ligand 1 (PD-1/PD-L1) inhibitor therapy is accompanied by companion or complementary PD-L1 testing in some tumour types. We investigated utilisation of the Dako PD-L1 IHC 28-8 and 22C3 pharmDx assays and the Ventana PD-L1 (SP142) assay and evaluated concordance between the 28-8 and 22C3 assays in a real-world cohort of patients tested at a single US national reference laboratory.

Methods: NeoGenomics Laboratories performed PD-L1 testing on tumour samples between October 2015 and March 2018. Read More

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http://dx.doi.org/10.1136/jclinpath-2020-206466DOI Listing

Comprehensive multiparameter genetic analysis improves circulating tumor DNA detection in head and neck cancer patients.

Oral Oncol 2020 Jun 23;109:104852. Epub 2020 Jun 23.

Department of Otolaryngology - Head and Neck Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, the Netherlands. Electronic address:

Introduction: Tumor-specific genetic aberrations in cell-free DNA (cfDNA) from plasma are promising biomarkers for diagnosis of recurrent head and neck squamous cell carcinoma (HNSCC). However, the sensitivity when using somatic mutations only in cfDNA is suboptimal. Here, we combined detection of copy number aberrations (CNAs), human papillomavirus (HPV) DNA and somatic mutations in a single sequencing workflow. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104852DOI Listing

Pretreatment High MCV as Adverse Prognostic Marker in Nonanemic Patients with Head and Neck Cancer.

Laryngoscope 2020 Jun 26. Epub 2020 Jun 26.

Department of Neurosciences, Section of Otolaryngology, University of Padova, Treviso, Italy.

Objective: Mean corpuscular volume (MCV) has been shown in to be a reliable prognostic marker in other cancers; however, no evidence exists on its use in head and neck squamous cell carcinoma (HNSCC). This study aimed to investigate the association between MCV, hemoglobin, platelet count and albumin concentration, and survival in stage III/IVA-B HNSCC treated with concurrent chemoradiotherapy.

Study Design: Retrospective cohort study. Read More

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http://dx.doi.org/10.1002/lary.28882DOI Listing

The crosstalk between AXL and YAP promotes tumor progression through STAT3 activation in head and neck squamous cell carcinoma.

Cancer Sci 2020 Jun 26. Epub 2020 Jun 26.

Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, No 639, Zhizaoju Rd, Shanghai, 200011, China.

Receptor tyrosine kinases (RTKs) and Yes-associated protein (YAP) are critical driving factors in tumors. Currently, the regulation of RTKs in the Hippo-YAP pathway has been recognized as an important issue. However, the relationship between AXL, one of the RTKs, and YAP in head and neck squamous cell carcinoma (HNSCC) remains unknown. Read More

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http://dx.doi.org/10.1111/cas.14546DOI Listing

Role of cancer stem cell markers ALDH1, BCL11B, BMI-1, and CD44 in the prognosis of advanced HNSCC.

Strahlenther Onkol 2020 Jun 25. Epub 2020 Jun 25.

Department of Pathology, University Medical Center Göttingen, Göttingen, Germany.

Purpose: Cancer stem cells (CSCs) are held accountable for the progress of head and neck squamous cell carcinoma (HNSCC). In the presented study, the authors evaluated the prognostic value of CSC markers in two particular HNSCC cohorts.

Methods: This two cohort study consisted of 85 patients with advanced stage HNSCC, treated with primary radio(chemo)therapy (pRCT), and 95 patients with HNSCC, treated with surgery and partially adjuvant radio(chemo)therapy. Read More

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http://dx.doi.org/10.1007/s00066-020-01653-5DOI Listing

Dynamics of Serum Tumor Markers Can Serve as a Prognostic Biomarker for Chinese Advanced Non-small Cell Lung Cancer Patients Treated With Immune Checkpoint Inhibitors.

Front Immunol 2020 10;11:1173. Epub 2020 Jun 10.

Department of Oncology, The First Medical Center of Chinese PLA General Hospital, Beijing, China.

Serum tumor markers carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), cytokeratin 19 fragment (CYFRA21-1) and squamous-cell carcinoma-related antigen (SCC-Ag) are routinely used for monitoring the response to chemotherapy or targeted therapy in advanced-stage non-small cell lung cancer (NSCLC), however their role in immunotherapy remains unclear. The aim of this study was to investigate whether dynamics of these serum markers were associated with the efficacy and prognosis of Chinese late-stage NSCLC patients treated with programmed cell death-1/programmed cell death ligand-1 (PD-1/PD-L1) inhibitors. We initiated a longitudinal prospective study on advanced NSCLC patients treated with PD-1/PD-L1 inhibitors in Chinese PLA general hospital (Beijing, China). Read More

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http://dx.doi.org/10.3389/fimmu.2020.01173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298878PMC

Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival.

Sci Rep 2020 Jun 25;10(1):10382. Epub 2020 Jun 25.

Postgraduate Program in Biotechnology/RENORBIO, Federal University of Espirito Santo, Av. Marechal Campos, 1468, Vitoria, 29.040-090, ES, Brazil.

Oral cancer squamous cell carcinoma (OCSCC) mainly affects individuals aged between 50 and 70 years who consume tobacco and alcohol. Tobacco smoke contains hundreds of known toxic and carcinogenic molecules, and a few studies have sought to verify the relationship of such trace elements as risk or prognostic factors for head and neck cancer. We obtained 78 samples of tumor tissues from patients with OCSCC, and performed a qualitative elemental characterization using the micro X-Ray Fluorescence technique based on synchrotron radiation. Read More

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http://dx.doi.org/10.1038/s41598-020-67270-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316707PMC

Impact of SRY-Box Transcription Factor 11 Gene Polymorphisms on Oral Cancer Risk and Clinicopathologic Characteristics.

Int J Mol Sci 2020 Jun 23;21(12). Epub 2020 Jun 23.

Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.

Oral cancer is among the most common cancers worldwide and has become a major global health problem because of its relatively high morbidity and mortality rates. The sex-determining region on the Y-chromosome-related high-mobility-group box (SOX) transcription factor 11 (SOX11) plays a key role in human development and differentiation and is frequently increased in various human cancers. However, the clinical significance of SOX11 polymorphisms in oral cancer and their association with oral cancer risk are unclear. Read More

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http://dx.doi.org/10.3390/ijms21124468DOI Listing

The Role of Ataxia Telangiectasia Mutant and Rad3-Related DNA Damage Response in Pathogenesis of Human Papillomavirus.

Pathogens 2020 Jun 23;9(6). Epub 2020 Jun 23.

Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, China.

Human papillomavirus (HPV) infection leads to a variety of benign lesions and malignant tumors such as cervical cancer and head and neck squamous cell carcinoma. Several HPV vaccines have been developed that can help to prevent cervical carcinoma, but these vaccines are only effective in individuals with no prior HPV infection. Thus, it is still important to understand the HPV life cycle and in particular the association of HPV with human pathogenesis. Read More

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http://dx.doi.org/10.3390/pathogens9060506DOI Listing

Expression of let-7i and miR-192 is associated with resistance to cisplatin-based chemoradiotherapy in patients with larynx and hypopharynx cancer.

Oral Oncol 2020 Jun 22;109:104851. Epub 2020 Jun 22.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Medical Oncology, Cancer Center Amsterdam, the Netherlands. Electronic address:

Objectives: The majority of patients with locally advanced larynx or hypopharynx squamous cell carcinoma are treated with organ-preserving chemoradiotherapy (CRT). Clinical outcome following CRT varies greatly. We hypothesized that tumor microRNA (miRNA) expression is predictive for outcome following CRT. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104851DOI Listing

Non-HPV-Related Head and Neck Squamous Cell Carcinoma in a Young Patient Cohort.

Ear Nose Throat J 2020 Jun 25:145561320935839. Epub 2020 Jun 25.

Department of Otolaryngology-Head and Neck Surgery, University of Virginia Health System, Charlottesville, VA, USA.

Objectives: Head and neck squamous cell carcinoma (HNSCC) is rare in patients younger than 40 years. Many practitioners suspect HNSCC is a more aggressive disease in this age group, and perhaps increasing in incidence; however, there are scant and conflicting data to support this assertion. We sought to compare outcomes for young patients with non-human papillomavirus (HPV)-related HNSCC to those of older patients. Read More

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http://dx.doi.org/10.1177/0145561320935839DOI Listing