2,093 results match your criteria Head and Neck Cancer - Resection and Neck Dissection


Step-by-Step Cadaver Dissection and Surgical Technique for Compartmental Tongue and Floor of Mouth Resection.

Front Oncol 2021 23;11:613945. Epub 2021 Apr 23.

Department of Otorhinolaryngology - Head and Neck Surgery, "San Maurizio" Hospital, Bolzano, Italy.

Background: The aim of oral cancer surgery is tumor removal within clear margins of healthy tissue: the latter definition in the literature, however, may vary between 1 and 2 cm, and should be intended in the three dimensions, which further complicates its precise measurement. Moreover, the biological behavior of tongue and floor of mouth cancer can be unpredictable and often eludes the previously mentioned safe surgical margins concept due to the complexity of tongue anatomy, the intricated arrangements of its intrinsic and extrinsic muscle fibers, and the presence of rich neurovascular and lymphatic networks within it. These structures may act as specific pathways of loco-regional tumor spread, allowing the neoplasm to escape beyond its visible macroscopic boundaries. Read More

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Free flap transfer, a safe and efficient method for reconstruction of composite skull base defects after salvage resection of advanced intra- and extracranial communicating tumors: Short title Free flap transfer for reconstruction of composite skull base defects.

World Neurosurg 2021 Apr 30. Epub 2021 Apr 30.

Department of Neurosurgery, National Cancer Center/ National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100021, China. Electronic address:

Object: Surgical treatment of advanced intra- and extracranial communicating skull base tumors is challenging, especially for the reconstruction of the large composite defect left by tumor resection. The aim of the study is to evaluate the utility of the free flap reconstruction of the defects resulting from radical resection of these tumors in a single institution.

Methods: The clinical data of 17 consecutive patients who underwent free flap reconstruction for defect left by salvage resection of advanced intra- and extracranial communicating tumors from 2013 to 2019 were retrospectively collected and analyzed. Read More

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The addition of chemotherapy to adjuvant radiation is associated with inferior survival outcomes in intermediate-risk HPV-negative HNSCC.

Cancer Med 2021 May 2. Epub 2021 May 2.

Division of Medical Oncology, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Background: Only high-risk tumors with extranodal extension (ENE) and/or positive surgical margins (PSM) benefit from adjuvant therapy (AT) with concurrent chemoradiation (CRT) compared to radiation therapy (RT) in locally advanced head and neck squamous cell carcinoma (HNSCC). Optimal treatment for intermediate-risk tumors remains controversial. We categorized patients based on their surgical pathologic risk factors and described AT treatment patterns and associated survival outcomes. Read More

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Progress in application of near-infrared fluorescence imaging in the diagnosis and treatment of oral cancer.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Mar;46(3):316-321

Breast Oncoplastic Surgery Department/ Head and Neck Surgery Department 3, Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410006.

The preliminary screening of oral cancer mostly depends on the experience of clinicians, The surgical margin of tumor is mostly based on physical examination and preoperative imaging examination. It lacks real-time and objective intraoperative evaluation methods. Indocyanine green (ICG), as a safe and pollution-free organic fluorescent pigments, combined with near-infrared fluorescence imaging can be applied in the screening of early oral cancer, the determination of tumor resection margins, sentinel lymph node biopsy, cervical lymph node dissection, targeted chemotherapy, and other aspects. Read More

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Optimal Management of the Unilateral Recurrent Laryngeal Nerve Involvement in Patients with Thyroid Cancer.

Cancers (Basel) 2021 Apr 28;13(9). Epub 2021 Apr 28.

Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kumamoto University, Kumamoto 860-8555, Japan.

We aimed to determine the optimal management of recurrent laryngeal nerve (RLN) involvement in thyroid cancer. We enrolled 80 patients with unilateral RLN involvement in thyroid cancer between 2000 and 2016. Eleven patients with preoperatively functional vocal folds (VFs) underwent sharp tumor resection to preserve the RLN (shaving group). Read More

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Consensus recommendations from the Czech Head and Neck Cancer Cooperative Group (2019): definition of surgical margins status, neck dissection reporting, and HPV/p16 status assessment.

Cesk Patol 2021 ;57(1):53-56

The Czech Head and Neck Cancer Cooperative Group (CHNCCG) held a meeting in Tabor on 11-12 October 2019 with the aim of reaching an interdisciplinary consensus on some controversial points where international unity is absent. The meeting resulted in recommendations on resection margin size terminology (definition of terms: negative margin, close margin and positive margin) and on the adoption of terminology for neck dissections reporting according to the International Recommendation of the International Head and Neck Scientific Group and on assessment of HPV/p16 status in head and neck tumors. Read More

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Transoral robotic surgery versus nonrobotic resection of oropharyngeal squamous cell carcinoma.

Head Neck 2021 Apr 26. Epub 2021 Apr 26.

Division of Otolaryngology - Head & Neck Surgery, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.

The aim of this study is to evaluate the impact of transoral robotic surgery (TORS) compared to nonrobotic surgery (NRS) on overall survival in oropharyngeal squamous cell carcinoma (OPSCC). We performed a retrospective study of patients with HPV+ and HPV- OPSCC undergoing TORS or NRS with neck dissection using the National Cancer Database from the years 2010-2016. Among patients with OPSCC in our cohort, 3167 (58. Read More

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Relationship between the extent of central node dissection and parathyroid function preservation in thyroid cancer surgery.

Gland Surg 2021 Mar;10(3):1093-1103

Department of Head and Neck Surgery, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Background: The risk and effect of hypocalcemia following surgery of different magnitudes remains unclear. Thus, we assessed whether different extents of central lymph node dissection (CLND) and status of preserved parathyroid glands can influence parathyroid function in differentiated thyroid carcinoma (DTC) patients with initial surgical resection.

Methods: Participants were categorized into 6 groups based on the extent of the surgical procedures, number of parathyroid glands preserved , and parathyroid autotransplantation. Read More

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The application of chimeric deep circumflex iliac artery perforator flap for oromandibular reconstruction: A case report.

Medicine (Baltimore) 2021 Apr;100(14):e25458

Department of Head and Neck Cancer Center.

Rationale: The free fibular flap is considered the gold standard, particularly for a mandibular defect combined with a significant soft tissue defect. However, the fibular flap has the disadvantages of a lack of height for postoperative dental restoration and donor site skin graft if the skin paddle is wider than 5 cm. The larger bone and soft tissue defects tend to be reconstructed using either a scapula or a combination of iliac artery and radial free flap. Read More

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Protective strategy of parathyroid glands during thyroid lobectomy: A retrospective cohort and case-control study.

Medicine (Baltimore) 2021 Apr;100(14):e21323

Center of Thyroid & Parathyroid Surgery.

Abstract: Parathyroid protection during thyroid lobectomy was not illustrated previously. Aim of this study was to find out the influence of parathyroid glands in situ preservation and autotransplantation on postoperative parathyroid function in thyroid lobectomy.Consecutive patients who underwent primary thyroid lobectomy with unilateral central neck dissection for papillary thyroid carcinoma in our center were included retrospectively. Read More

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Endoscopic-assisted multi-portal compartmental resection of the masticatory space in oral cancer: Anatomical study and preliminary clinical experience.

Oral Oncol 2021 Apr 4;117:105269. Epub 2021 Apr 4.

Unit of Otorhinolaryngology, "San Maurizio" Hospital of Bolzano, Bolzano, Italy.

Objectives: To present an anatomical cadaver dissection study and our preliminary surgical experience with endoscopic-assisted multi-portal compartmental resection of the masticatory space (MS) in locally advanced oral squamous cell carcinoma (OSCC) of the retromolar area.

Materials And Methods: Two fresh-frozen cadaver heads were dissected in the Laboratory of Anatomy to define the surgical steps of an endoscopic-assisted multi-portal compartmental approach to the MS. After this preclinical anatomical study, patients affected by locally advanced OSCC originating from the retromolar area with extension to the MS were prospectively enrolled and operated at two Italian referral centers for head and neck cancer between October 2019 and May 2020. Read More

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High-grade Transformation/Dedifferentiation in Salivary Gland Carcinomas: Occurrence Across Subtypes and Clinical Significance.

Adv Anat Pathol 2021 May;28(3):107-118

International Head and Neck Scientific Group, Padua, Italy.

High-grade transformation (HGT) or dedifferentiation has been described in a variety of salivary gland carcinomas, including acinic cell carcinoma, secretory carcinoma, adenoid cystic carcinoma, epithelial-myoepithelial carcinoma, polymorphous adenocarcinoma, low-grade mucoepidermoid carcinoma, and hyalinizing clear cell carcinoma. High-grade (HG) transformed tumors are composed of a conventional low-grade component characterized by specific microscopic and immunohistochemical features for the given entity, intermingled with or juxtaposed to areas of HG morphology. This is usually either poorly differentiated adenocarcinoma, carcinoma not otherwise specified, or undifferentiated carcinoma, in which the original line of differentiation is lost. Read More

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Transoral Robotic Surgery for Pharyngeal and Laryngeal Cancers-A Prospective Medium-Term Study.

J Clin Med 2021 Mar 2;10(5). Epub 2021 Mar 2.

School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.

Transoral robotic surgery (TORS) has been used for treating pharyngeal and laryngeal cancers for many years. However, the application of neoadjuvant chemotherapy (NACT) before TORS, the sparing rate of adjuvant irradiation after TORS, and the long-term oncologic/functional outcomes of TORS are seldom reported. From September 2014 to May 2018, 30 patients with clinical T1 to T3 cancers of oropharynx (7), larynx (3), and hypopharynx (20) were prospectively recruited for TORS in a tertiary referral medical center. Read More

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Does Submandibular Gland Sacrificing Neck Dissection Decrease Salivary Output and Quality of Life?

ORL J Otorhinolaryngol Relat Spec 2021 Mar 23:1-6. Epub 2021 Mar 23.

Professor, Department of Otorhinolaryngology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Purpose: Our study aimed to quantify the impact of submandibular gland (SMG) resection during Level I neck dissection (ND) on stimulated salivary output (SSO) and xerostomia-related quality of life in patients with head and neck cancer (HNC).

Methods: A retrospective cohort was formed from 32 patients that underwent unilateral or bilateral Level I ND and a control group of 23 patients that had level II-IV ND. SSO (Saxon test) and University of Washington Quality of Life survey results for both groups were compared. Read More

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Pericardial metastasis of parotid mucoepidermoid carcinoma diagnosed by pericardial biopsy.

Auris Nasus Larynx 2021 Mar 6. Epub 2021 Mar 6.

Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, 6-7-1, Shinjuku-ku, Tokyo, Nishishinjuku 160-0023, Japan.

A 30-year-old man presented with swelling in the lower left ear. Close examination led to a diagnosis of parotid gland cancer, T4N0M0 Stage IVA, so total resection of the left parotid gland and left neck dissection were performed. Pathological examination led to a diagnosis of high-grade malignant-type mucoepidermoid, and chemoradiotherapy was performed as postoperative treatment. Read More

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Chondrosarcoma of the parapharyngeal space: Case report and literature review of an extremely rare location.

Radiol Case Rep 2021 May 26;16(5):1099-1102. Epub 2021 Feb 26.

Department of Radiotherapy, Faculty of Medicine, Mohammed VI University of Health Sciences/Cheikh Khalifa International University Hospital, 82403, Oum Rabii, Hay Hassani, Casablanca, Morocco.

Chondrosarcoma of the head and neck region is a rare disease, representing approximately 0.1% of all head and neck neoplasms. Parapharyngeal location is extremely rare and low-grade ones are even rarer. Read More

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Triplet induction chemotherapy followed by less invasive surgery without reconstruction for human papillomavirus-associated oropharyngeal cancers: Why is it successful or unsuccessful?

Int J Clin Oncol 2021 Mar 8. Epub 2021 Mar 8.

Division of Radiation Oncology, Shizuoka Cancer Center, Shizuoka, Japan.

Background: De-escalating treatments have been focused on for HPV-associated oropharyngeal squamous cell carcinoma (OPSCC). We assessed the efficacy of a triplet induction chemotherapy (ICT) followed by surgery with or without neck dissection (ND) for locally advanced OPSCC, aiming at less invasive surgery without free-flap reconstruction and avoiding postoperative irradiation.

Methods: This was a retrospective study of 41 patients with advanced resectable HPV-positive OPSCC who underwent ICT followed by surgery of primary resection with or without ND. Read More

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Primary squamous cell carcinoma of the thyroid gland successfully treated with surgical resection and adjuvant chemoradiotherapy.

BMJ Case Rep 2021 Mar 1;14(3). Epub 2021 Mar 1.

Department of Otolaryngology, Wrightington, Wigan and Leigh NHS Foundation Trust, Wigan, UK.

A 57-year-old woman presented with a 3-month history of an enlarging thyroid mass causing breathlessness and dysphagia. Cross-sectional imaging showed a thyroid tumour infiltrating the trachea and abutting the oesophagus. She underwent panendoscopy, total thyroidectomy and planned tracheal resection, but due to intraoperative findings, a staged procedure was planned instead. Read More

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Repeated loss of consciousness as the first symptom of recurrence of head and neck malignancy: a case report.

Eur Heart J Case Rep 2021 Jan 4;5(1):ytaa430. Epub 2021 Jan 4.

Department of Cardiovascular Medicine, National Cerebral & Cardiovascular Centre, 6-1 Kishibeshinmachi, Suita, Osaka 564-8565, Japan.

Background: Head and neck malignancies rarely cause reflex syncope. Three mechanistic patterns of reflex syncope are known in such patients: carotid sinus syndrome, glossopharyngeal neuralgia syndrome, and parapharyngeal space lesions syncope syndrome. There are few reports describing parapharyngeal space lesions syncope syndrome. Read More

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January 2021

Retrospective analysis of outcome and toxicity after postoperative radiotherapy in patients with squamous cell carcinoma of the lip.

Tumori 2021 Mar 1:300891621996805. Epub 2021 Mar 1.

Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany.

Background: Carcinomas of the lips are a relatively common malignancy of the head and neck region, accounting for roughly one quarter of all oral cavity cancers. Compared to other oral cancer sites, this location has a favorable prognosis, with 5-year survival rates between 85% and 95%. This study summarizes our institutional experience in utilizing postoperative radiation for patients with squamous cell carcinoma of the upper and/or lower lip following incomplete surgical resection or positive lymph node involvement with extracapsular extension. Read More

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Two cases of rare thyroid malignancy-case report.

Gland Surg 2021 Jan;10(1):386-394

Department of Otolaryngology Head and Neck, Tianjin First Central Hospital, Tianjin, China.

We report 2 cases of rare thyroid malignancy: angiosarcoma and myoepithelial carcinoma (MC). Thyroid angiosarcomas (TAS) is extremely rare and comprises less than 1% of primary thyroid cancer worldwide. MC usually presents as a slow-growing painless mass arising in the salivary glands. Read More

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January 2021

Metachronous primary cancer of the tongue and malignant lymphoma of the small intestine: A case report.

Medicine (Baltimore) 2021 Feb;100(7):e24806

Department of Oral and Maxillofacial Surgery, Iwata City Hospital, Iwata.

Rationale: Oral cancer often causes secondary primary cancers in the upper gastrointestinal tract. However, there are no reports of secondary primary cancers in patients with oral squamous cell carcinoma and malignant lymphoma of the small intestine. This report describes a case of metachronous multiple primary cancers of the tongue and small intestine malignant lymphoma. Read More

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February 2021

Case control study comparing the HPV genome in patients with oral cavity squamous cell carcinoma to normal patients using metagenomic shotgun sequencing.

Sci Rep 2021 Feb 16;11(1):3867. Epub 2021 Feb 16.

Department of Pathology, New York University School of Medicine, New York, 10016, USA.

The aim of this study was to carry out a case control study comparing the HPV genome in patients with oral cavity squamous cell carcinoma (OC-SCC) to normal patients using metagenomic shotgun sequencing. We recruited 50 OC-SCC cases which were then matched with a control patient by age, gender, race, smoking status and alcohol status. DNA was extracted from oral wash samples from all patients and whole genome shotgun sequencing performed. Read More

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February 2021

A Rare Case of Oral Mucosal Amelanotic Melanoma in a 77-year-old Immunocompromised Man.

J Clin Aesthet Dermatol 2021 Jan 1;14(1):27-29. Epub 2021 Jan 1.

All authors are with Largo Medical Center in Largo, Florida.

Primary mucosal melanomas are rare neoplasms that occur in the mouth, esophagus, nasopharynx, larynx, and anogenital mucosa. Mucosal melanomas are rare, accounting for approximately one percent of all melanomas. Of the mucosal melanomas that occur in the head and neck, oral mucosal melanomas compose approximately 25 percent. Read More

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January 2021

Anatomical-based classification for transoral base of tongue resection.

Head Neck 2021 May 13;43(5):1604-1609. Epub 2021 Feb 13.

Depatment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.

Background: To propose a classification of transoral base of tongue (BOT) procedures able to provide uniform terminology in order to better define postoperative results.

Methods: The classification resulted from the consensus of the different authors and is based on anatomical and surgical principles.

Results: The classification comprises three types of BOT resections: type 1 is the resection of the entire lingual tonsil to the muscular plane; type 2 is performed by removing the entire lingual tonsil and part of BOT muscles; type 3 is performed by removing the entire lingual tonsil and the entire BOT muscles. Read More

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Medial clavicle fracture with bone destruction after radical neck dissection combined with postoperative chemotherapy for secondary cervical lymph node metastasis of tongue cancer: a case report.

Oral Radiol 2021 Feb 12. Epub 2021 Feb 12.

Division of Oral and Maxillofacial Radiology, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari-Tobetsu, Hokkaido, 061-0293, Japan.

Background: Clavicle fractures (CF) after radical neck dissection (RND) for oral cancer are rare but are thought to occur as a result of myotonia and decreased blood supply to the muscles around the clavicle after RND. The current report presents a rare case of a non-neoplastic pathological CF after RND, and discusses the role of imaging examinations for the timely detection of CF.

Case Report: An 82-year-old Japanese man underwent RND followed by chemotherapy without radiotherapy for secondary metastasis of the right cervical lymph node after resection of tongue cancer. Read More

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February 2021

Surgical Treatment of Advanced Thyroid Cancer with Tracheal Invasion.

Case Rep Endocrinol 2021 29;2021:8823405. Epub 2021 Jan 29.

Department of Oncology, Hanoi Medical University, Hanoi, Vietnam.

Introduction: Tracheal invasion in thyroid cancer occurs in one-third of locally advanced cases and is the third most common site of infiltration following strap muscles and recurrent laryngeal nerves. Surgical resection plays an important role in the management strategy followed by either radioactive iodine or external beam radiotherapy. Nonetheless, there has been still controversy about the optimal extension of the surgery. Read More

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January 2021

Radioactive iodine-125 seed localization as an aid in reoperative neck surgery.

Am J Surg 2021 03 11;221(3):534-537. Epub 2021 Jan 11.

NorthShore University HealthSystem, 2650 Ridge Ave., Walgreen Suite 2507, Evanston, IL, 60201, USA.

Background: Scarring and disrupted tissue planes add to already-complex neck anatomy and make localization of nonpalpable pathology difficult in cervical endocrine reoperations. We describe the use of radioactive iodine-125 seed localization (RSL) in 6 patients with metastatic papillary thyroid carcinoma (PTC) and 2 with recurrent hyperparathyroidism.

Methods: Eight patients had 2-D ultrasound-guided RSL of the target lesion, 0-3 days preoperatively. Read More

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Cavernous sinus thrombosis: a late complication of head and neck surgery.

BMJ Case Rep 2021 Feb 4;14(2). Epub 2021 Feb 4.

Surgical Oncology, All India Institute of Medical Sciences, New Delhi, India.

Cavernous sinus thrombosis is a rare but fatal condition arising due to various infectious and noninfectious causes. Although its incidence is very low in the setting of head and neck surgery, including radical neck dissection, a high index of suspicion with prompt treatment is the key to a successful outcome. We report a case of a 50-year-old woman with a chondrosarcoma of left lower alveolobuccal complex who underwent en bloc tumour resection with infratemporal fossa clearance and left modified radical neck dissection. Read More

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February 2021

[Construction and verification of lymph node metastasis model of cN0 stage thyroid micropapillary carcinoma and discussion of surgical methods].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Feb;35(2):137-140

Breast and Thyorid Surgery,the Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China.

To construct and verify a model of lymph node metastasis in cN0 stage thyroid micropapillary carcinoma. To explore the significance of thyroid gland lobectomy combined with prophylactic zone Ⅵ lymph node dissection in cN0 stage thyroid micropapillary carcinoma surgery. The clinical data of 670 patients with cN0 stage thyroid micropapillary carcinoma and area Ⅵ lymph node dissection were collected. Read More

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February 2021