Search Our Scientific Publications & Authors

J Surg Res 2022 Jun 24;279:113-118. Epub 2022 Jun 24.

Children's Hospital New Orleans, New Orleans, Louisiana; Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana.

Introduction: Youth in the juvenile justice system are a vulnerable, high-risk population. While the role of pediatricians and mental health professionals in providing care for these children is well studied, the surgical needs of this population are not well understood. We sought to characterize the physical trauma and surgical subspecialty needs of this population. Read More

Facial Plast Surg Aesthet Med 2022 Jun 28. Epub 2022 Jun 28.

Department of Otolaryngology - Head and Neck Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Orbital wall fractures are often associated with concomitant ocular injury. In some cases, detection and treatment of such injuries requires ophthalmology evaluation. To identify a change in ocular management as a result of ophthalmology evaluation in patients with orbital wall fractures. Read More

J Spinal Cord Med 2022 Jul;45(4):556-563

Department of Orthopedics, The First Affiliated Hospital of Nanchang University, College of Medicine, Nanchang, Jiangxi, People's Republic of China.

Study Design: A hospital-based retrospective epidemiological study.

Objective: To describe the recent epidemiological profile and characteristics of traumatic cervical spinal cord injury (TCSCI) in Nanchang, Jiangxi Province, China.

Setting: The First Affiliated Hospital of Nanchang University, The Second Affiliated Hospital of Nanchang University and The Third Affiliated Hospital of Nanchang University. Read More

Shock 2022 Jun;57(6):251-259

Department of Surgery, Division of Trauma and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Background: Traumatic brain injury (TBI) is an underrecognized public health threat. Survivors of TBI often suffer long-term neurocognitive deficits leading to the progressive onset of neurodegenerative disease. Recent data suggests that the gut-brain axis is complicit in this process. Read More

Radiol Med 2022 Jun 27. Epub 2022 Jun 27.

Department of Emergency Radiology, Azienda Ospedaliera San Camillo-Forlanini, Circonvallazione Gianicolense 87, 00152, Rome, Italy.

Electric scooters have become very popular over the past five years. However, their growing popularity and their easy availability are strongly related to an increasing number of injuries. These accidents are more common among young people and typically occurred during the night. Read More

J Craniofac Surg 2022 Jun 27. Epub 2022 Jun 27.

Division of Plastic and Reconstructive Surgery, Children's Hospital of Philadelphia, Philadelphia, PA.

Introduction: Although single institution studies have analyzed various animal attacks, there has not been multicenter investigation into dog bites in children. The purpose of this study was to characterize national trends and investigate the characteristics of pediatric dog bites.

Methods: Aretrospective cohort study was conducted of pediatric dog bite injuries in the United States from 2015 to 2020 using the Pediatric Health Information System national database. Read More

Mater Today Bio 2022 Jun 10;15:100321. Epub 2022 Jun 10.

Department of Otolaryngology, School of Medicine, Ajou University, Suwon, South Korea.

Silk is a promising biomaterial for injectable hydrogel, but its long-gelation time and cytotoxic crosslinking methods are the main obstacles for clinical application. Here, we purpose a new crosslinking technique of silk-alginate (S-A) injectable hydrogel using liquid-type non-thermal atmospheric plasma (LTP) in vocal fold (VF) wound healing. We confirmed that LTP induces the secondary structure of silk in a dose-dependent manner, resulting in improved mechanical properties. Read More

J Neurol Surg Rep 2022 Apr 24;83(2):e54-e62. Epub 2022 Jun 24.

Department of Surgery, St. Luke's University Health Network, Bethlehem, Pennsylvania, United States.

Nail gun use and its associated incidence of injury have continued to increase since it was first introduced in 1959. While most of these injuries involve the extremities, a subset of patients suffer intracranial trauma. The most recent comprehensive review on this particular subject referenced 41 cases and advocated for further discussion regarding proper treatment plans for these individuals. Read More

Cureus 2022 May 24;14(5):e25289. Epub 2022 May 24.

Internal Medicine & Geriatrics, Oregon Health & Science University, Portland, USA.

Angiosarcoma is an exceptionally rare malignancy that accounts for less than 1% of all sarcomas. This case describes a 90-year-old male veteran who presented with a hematoma from a traumatic head injury. This then progressed to an ulcerated bleeding lesion that measured 2. Read More

Neurohospitalist 2022 Jul 28;12(3):444-452. Epub 2022 Mar 28.

Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Objective: To assess the clinical, racial, and social characteristics of victims of Gunshot wounds (GSWs) to the head and assess for associations between these factors and outcomes.

Summary Background Data: Previous literature has not focused on the association of race and socioeconomic factors with these specific injuries.

Methods: We identified patients with GSWs to the head who presented to 2 urban academic medical centers between 1998 and 2020, and extracted patient-level demographic data, information about the clinical and surgical course, and outcomes at discharge and follow-up. Read More

Front Hum Neurosci 2022 9;16:868074. Epub 2022 Jun 9.

Spaulding Rehabilitation Hospital, Cambridge, MA, United States.

Humans routinely modify their walking speed to adapt to functional goals and physical demands. However, damage to the central nervous system (CNS) often results in abnormal modulation of walking speed and increased risk of falls. There is considerable interest in treatment modalities that can provide safe and salient training opportunities, feedback about walking performance, and that may augment less reliable sensory feedback within the CNS after injury or disease. Read More

Comput Methods Biomech Biomed Engin 2022 Jun 25:1-10. Epub 2022 Jun 25.

Department of Biomedical Engineering, Islamic Azad University, Central Tehran Branch, Tehran, Iran.

Subdural hematoma (SDH) is common abnormality that is caused by the rupture of cerebral bridge veins (BVs). It occurs in more than 30% of severe head injuries. The purpose of this research was to develop a numerical model to examine the effects of brain atrophy and age on the rupture of bridging veins in subdural hematoma. Read More

Injury 2022 Jun 12. Epub 2022 Jun 12.

Professor-Section Head Trauma & Orthopaedic Surgery School of Medicine University of Leeds, UK. Electronic address:

Meta-analyses constitute fundamental tools of the Evidence-Based Medicine (EBM) aiming at synthesizing outcome data from individual trials in order to produce pooled effect estimates for various outcomes of interest. Combining summary data from several studies increases the sample size, improves the statistical power of the findings as well as the precision of the obtained effect estimates. For all these reasons, meta-analyses are thought of providing the best evidence to support clinical practice guidelines. Read More

J Biomed Inform 2022 Jun 23:104122. Epub 2022 Jun 23.

Head of Research, Datafoundry AI, Bangalore, India.

Recently Artificial Intelligence(AI) has not only been used to diagnose the disease but also to cure the disease. Researchers started using AI for drug discovery. Predicting the Adverse Drug Reactions(ADRs) caused by the drug in the manufacturing stage or in the clinical trial stage is a very important problem in drug discovery. Read More

Int J Surg Case Rep 2022 Jun 22;96:107338. Epub 2022 Jun 22.

Department of Biomedical Science, Hematologic Unit, University of Catania, Policlinico "G. Rodolico-San Marco", Via S. Sofia 78, 95123 Catania, Italy.

Introduction: Purtscher's retinopathy causes sudden loss of vision of varying severity, secondary to head injury or chest compression. Its pathophysiology is unclear. Purtscher's-like retinopathy has more attenuated clinical and objective features and can be associated with many non-neoplastic pathologies. Read More

Ann Emerg Med 2022 Jun 22. Epub 2022 Jun 22.

University of Utah School of Medicine, Salt Lake City, UT.

Study Objective: To measure the effectiveness of a multimodal strategy, including simultaneous implementation of a clinical decision support system, to sustain adherence to a clinical pathway for care of children with minor head trauma treated in general emergency departments (EDs).

Methods: Prospective, type III hybrid effectiveness-implementation cohort study with a nonrandomized stepped-wedge design and monthly repeated site measures. The study population included pediatric minor head trauma encounters from July 2018 to December 2020 at 21 urban and rural general ED sites in an integrated health care system. Read More

J Physiol 2022 Jun 25. Epub 2022 Jun 25.

ICORD, Faculty of Medicine, University of British Columbia, Vancouver, BC.

Key Points: Cervical spinal cord injury (C-SCI) alters both the cardiac and respiratory systems, however little is known as to how these systems interact following injury. Here, we manipulated inspiratory or expiratory intrathoracic pressure (ITP) to mechanistically test the role of the respiratory pump on circulatory function in highly-trained individuals with C-SCI and an able-bodied reference group. In individuals with C-SCI, greater ITP during expiratory loading caused dynamic hyperinflation that was associated with impaired left-ventricular filling. Read More

BMC Med Res Methodol 2022 Jun 24;22(1):177. Epub 2022 Jun 24.

Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine (MC5723), 401 Quarry Road, Stanford, CA, 94305-5723, USA.

Background: Accurate measurement of trajectories in longitudinal studies, considered the gold standard method for tracking functional growth during adolescence, decline in aging, and change after head injury, is subject to confounding by testing experience.

Methods: We measured change in cognitive and motor abilities over four test sessions (baseline and three annual assessments) in 154 male and 165 female participants (baseline age 12-21 years) from the National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) study. At each of the four test sessions, these participants were given a test battery using computerized administration and traditional pencil and paper tests that yielded accuracy and speed measures for multiple component cognitive (Abstraction, Attention, Emotion, Episodic memory, Working memory, and General Ability) and motor (Ataxia and Speed) functions. Read More

Bioorg Chem 2022 Jun 17;127:105973. Epub 2022 Jun 17.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, Yunnan, China. Electronic address:

Scopariusicides D-M (1-10), ten new ent-clerodane-based meroditerpenoids with a cyclobutane-fused γ/δ-lactone core, were isolated from Isodon scoparius. Their structures were determined by comprehensive analysis of spectroscopic data, single-crystal X-ray diffraction, chemical transformation, and TDDFT ECD calculation. A plausible biosynthetic pathway of 1-10 was proposed in which the asymmetrical cyclobutane ring was formed via a crossed "head-to-tail" intermolecular [2 + 2] cycloaddition in anti/syn facial approaches between an ent-clerodane lactone and a cis-4-hydroxycinnamic acid. Read More

Eur J Pediatr 2022 Jun 24. Epub 2022 Jun 24.

Department of Pediatrics, Spaarne Gasthuis, Haarlem en Hoofddorp, The Netherlands.

Currently, in young children with minor traumatic head injuries (MTHI) classified as intermediate risk (IR), PECARN recommends clinical observation over computer tomography (CT) scan depending on provider comfort, although both options being possible. In this study, we describe clinicians' choice and which factors were associated with this decision. This was a planned sub-study of a prospective multicenter observational study that enrolled 1006 children younger than 18 years with MTHI who presented to six emergency departments in The Netherlands. Read More

Comput Intell Neurosci 2022 14;2022:1429042. Epub 2022 Jun 14.

Department of Physical Education, Guizhou University of Finance and Economics, Guiyang 550025, Guizhou, China.

Basketball is one of the popular sports in colleges. Basketball injuries are a common thing, and the use of machine learning and other technologies can effectively reduce basketball injuries, which should start with prevention. Nonstandard basketball movements and lack of physical coordination will not only reduce sports efficiency for athletes but also increase the probability of injury. Read More

Arthrosc Sports Med Rehabil 2022 Jun 24;4(3):e1083-e1089. Epub 2022 May 24.

Section of Young Adult Hip Surgery, Division of Sports Medicine, Department of Orthopedic Surgery, Rush Medical College of Rush University, Rush University Medical Center, Chicago, Illinois, U.S.A.

Purpose: To compare joint distraction measured on ultrasound (US) with joint space width (JSW) measured on fluoroscopy in hip arthroscopy and to determine whether ultrasound guidance is as safe and effective as fluoroscopy, the current gold standard, for establishing arthroscopic portals.

Methods: Cadaveric whole-body specimens were positioned supine and subjected to 60 lbs. of unilateral axial traction using a distal femoral Steinman pin. Read More

Neurol Clin Pract 2022 Jun;12(3):273-274

Rockville Centre, NY.

Some American neurologists seem uncertain about their role in caring for head-injured athletes. My long neurologic career focusing on brain injury has taught me that neurologists have a unique clinical skill set and expertise that is invaluable to the medical care of patients with MTBI related to sports. Read More

Cureus 2022 May 20;14(5):e25161. Epub 2022 May 20.

Otolaryngology - Head and Neck Surgery, Maulana Azad Medical College, New Delhi, IND.

Introduction Despite the theoretical advantages of bleeding control, there is increased morbidity in postoperative pain, sleep disturbance, allergy, toxic shock syndrome, and mucosal injury with the nasal packing in septoplasty procedure for deviated nasal septum. Trans-septal suturing after septoplasty has been advocated as an effective alternative to conventional nasal packing. The current study aims to compare the frequency of subjective symptoms, such as postoperative nasal pain, nasal bleeding, postnasal drip, sleep disturbance, dysphagia, headache, and epiphora between the trans-septal suturing technique and nasal packing in septoplasty surgery. Read More

IBRO Neurosci Rep 2022 Jun 9;12:157-162. Epub 2022 Feb 9.

Uniformed Services University of the Health Sciences, Edward Hebert School of Medicine, Department of Pharmacology and Molecular Therapeutics, Bethesda, MD 20814, USA.

Mild traumatic brain injury (mTBI) or concussion is the most common form of TBI which frequently results in persistent cognitive impairments and memory deficits in affected individuals [1]. Although most studies have investigated the role of hippocampal synaptic dysfunction in earlier time points following a single injury, the long-lasting effects of mTBI on hippocampal synaptic transmission following multiple brain concussions have not been well-elucidated. Using a repetitive closed head injury (3XCHI) mouse model of mTBI, we examined the alteration of spontaneous synaptic transmission onto hippocampal CA1 pyramidal neurons by recording spontaneous excitatory AMPA receptor (AMPAR)- and inhibitory GABAR-mediated postsynaptic currents (sEPSCs and sIPSCs, respectively) in adult male mice 2-weeks following the injury. Read More

Sensors (Basel) 2022 Jun 20;22(12). Epub 2022 Jun 20.

Neurotoxin Research Center of Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Neurological Department of Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Shanghai 200065, China.

Abnormal movement of the head and neck is a typical symptom of Cervical Dystonia (CD). Accurate scoring on the severity scale is of great significance for treatment planning. The traditional scoring method is to use a protractor or contact sensors to calculate the angle of the movement, but this method is time-consuming, and it will interfere with the movement of the patient. Read More

Medicina (Kaunas) 2022 Jun 1;58(6). Epub 2022 Jun 1.

Third Department of General Surgery, Medical School, AHEPA University Hospital, Aristotle University of Thessaloniki, 54621 Thessaloniki, Greece.

: Recurrent laryngeal nerve injury is one of the major complications of thyroidectomy, with the lateral thyroid ligament (Berry's ligament) being the most frequent site of nerve injury. Neuromonitoring during thyroidectomy revealed three possible anatomical regions of the recurrent laryngeal nerve P1, P2, and P3. P1 represents the recurrent laryngeal nerve's caudal extralaryngeal part and is primarily associated with Berry's ligament. Read More

Medicina (Kaunas) 2022 May 26;58(6). Epub 2022 May 26.

The Department of Infectious Diseases and Travel Medicine, Louis Pasteur University Hospital, Rastislavova 43, 04011 Kosice, Slovakia.

Cerebrospinal fluid (CSF) leakage is a rare condition. Prompt diagnosis and early treatment of CSF leakage minimizes the risk of severe complications such as bacterial meningitis. Different diagnostic modalities are used to detect the site of CSF leakage but often with unreliable results. Read More

J Pers Med 2022 May 28;12(6). Epub 2022 May 28.

Department of Pediatrics, Radboud University Medical Center, Postbox 9101, 6500 HB Nijmegen, The Netherlands.

Nephrotoxicity is a common and dose-limiting side effect of platinum compounds, which often manifests as acute kidney injury or hypomagnesemia. This study aimed to investigate the genetic risk loci for platinum-induced nephrotoxicity. Platinum-treated brain tumor and head-neck tumor patients were genotyped with genome-wide coverage. Read More

Int J Mol Sci 2022 Jun 16;23(12). Epub 2022 Jun 16.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.

Traumatic optic neuropathy (TON) is a significant cause of vision loss and irreversible blindness worldwide. It is defined as retinal ganglion cell death and axon degeneration caused by injury. Optic nerve crush (ONC), a well-validated model of TON, activates retinal microglia and initiates neuroinflammation. Read More