609,603 results match your criteria Head & Neck[Journal]


Case of paediatric steroid-induced glaucoma showing extremely fast progression with deformation of lamina cribrosa.

Clin Exp Optom 2019 Apr 17. Epub 2019 Apr 17.

Department of Medicine, Seoul National University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1111/cxo.12908DOI Listing

Comparison of Place-versus-Pitch Mismatch between a Perimodiolar and Lateral Wall Cochlear Implant Electrode Array in Patients with Single-Sided Deafness and a Cochlear Implant.

Audiol Neurootol 2019 Apr 17;24(1):38-48. Epub 2019 Apr 17.

Department of Otorhinolaryngology and Head and Neck Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.

Background: In electric-acoustic pitch matching experiments in patients with single-sided deafness and a cochlear implant, the observed "mismatch" between perceived pitch and predicted pitch, based on the amended Greenwood frequency map, ranges from -1 to -2 octaves. It is unknown if and how this mismatch differs for perimodiolar versus lateral wall electrode arrays.

Objectives: We aimed to investigate if the type of electrode array design is of influence on the electric-acoustic pitch match. Read More

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http://dx.doi.org/10.1159/000499154DOI Listing

An Extended Endoscopic Endonasal Approach for Sellar Area Chondrosarcoma: A Case Report and Literature Review.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, People's Republic of China.

Background: Chondrosarcoma is a malignant tumor that originates from mesenchymal cells that have differentiated into chondrocytes, often growing laterally, rarely seen in the cranium, and seldom seen in the saddle area. We believe that only a few cases have been reported in the literature. We report a case of pituitary fossa chondrosarcoma, which was completely resected by an extended endoscopic endonasal approach, and a literature review. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.075DOI Listing

Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.

Cell Rep 2019 Apr;27(3):860-871.e8

Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Inflammation Program, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Department of Otolaryngology-Head and Neck Surgery, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. Electronic address:

A truncating mutation in the mouse Srrm4 gene, which encodes a neuronal splicing factor, causes alternative splicing defects selectively in the ear. The mechanism by which splicing is preserved in the brain of these mice is not known. Here, we show that SRRM3 limits the Srrm4 mutation-associated defects to the ear and that, in cortical neurons, overlapping SRRM3-SRRM4 activity regulates the development of interneuronal inhibition. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.072DOI Listing

Control of Wheat Fusarium Head Blight by Heat-Stable Antifungal Factor (HSAF) from .

Plant Dis 2019 Apr 17:PDIS09181517RE. Epub 2019 Apr 17.

1 Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Jiangsu Key Laboratory for Food Quality and Safety, State Key Laboratory Cultivation Base of Ministry of Science and Technology, Nanjing 210014, P.R. China.

Heat-stable antifungal factor (HSAF), which belongs to the polycyclic tetramate macrolactam family, was isolated from fermentations and exhibited inhibitory activities against a wide range of fungal pathogens. In this study, the antifungal activity of HSAF against in vitro and in vivo was investigated. A total of 50% of mycelial growth of was suppressed with 4. Read More

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http://dx.doi.org/10.1094/PDIS-09-18-1517-REDOI Listing

Galvanic vestibular stimulation: from basic concepts to clinical applications.

J Neurophysiol 2019 Apr 17. Epub 2019 Apr 17.

Department Biology II, Ludwig-Maximilians-University Munich, Germany.

Galvanic vestibular stimulation (GVS) plays an important role in the quest to understand sensory signal processing in the vestibular system under normal and pathological conditions. It has become a highly relevant tool to probe neuronal computations and to assist in the differentiation and treatment of vestibular syndromes. Following its accidental discovery, GVS became a diagnostic tool that generates eye movements in the absence of head/body motion. Read More

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https://www.physiology.org/doi/10.1152/jn.00035.2019
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http://dx.doi.org/10.1152/jn.00035.2019DOI Listing
April 2019
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Non-Human Primate Vestibulo-Ocular Reflex Responses to Prosthetic Vestibular Stimulation are Robust to Pulse Timing Errors Caused by Temporal Discretization.

J Neurophysiol 2019 Apr 17. Epub 2019 Apr 17.

Otolaryngolgoy - Head & Neck Surgery, Johns Hopkins University, United States.

Electrical stimulation of vestibular afferent neurons to partially restore semicircular canal sensation of head rotation and the stabilizing reflexes that sensation supports has potential to effectively treat individuals disabled by bilateral vestibular hypofunction. Ideally, a vestibular implant system using this approach would be integrated with a cochlear implant, which would provide clinicians with a means to simultaneously treat loss of both vestibular and auditory sensation. Despite obvious similarities, merging these technologies poses several challenges, including stimulus pulse timing errors that arise when a system must implement a pulse-frequency-modulation encoding scheme (as is used in vestibular implants to mimic normal vestibular nerve encoding of head movement) within fixed-rate continuous interleaved sampling (CIS) strategies used in cochlear implants. Read More

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https://www.physiology.org/doi/10.1152/jn.00887.2018
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http://dx.doi.org/10.1152/jn.00887.2018DOI Listing
April 2019
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Multi-scale modeling of mechanotransduction in the utricle.

J Neurophysiol 2019 Apr 17. Epub 2019 Apr 17.

Biological Sciences, Ohio University, United States.

We review recent progress in using numerical models to relate utricular hair bundle and otoconial membrane structure to the functional requirements imposed by natural behavior in turtles. Section I reviews the evolution of experimental attempts to understand vestibular system function with emphasis on turtles, including data showing that accelerations occurring during natural head movements achieve higher magnitudes and frequencies than previously assumed. Section 2 reviews quantitative anatomical data documenting topographical variation in the structures underlying macromechanical and micromechanical responses of the turtle utricle to head movement: hair bundles, otoconial membrane (OM), and bundle-OM coupling. Read More

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http://dx.doi.org/10.1152/jn.00068.2019DOI Listing

A review on screening tests for vestibular disorders.

Authors:
Helen S Cohen

J Neurophysiol 2019 Apr 17. Epub 2019 Apr 17.

Bobby R Alford Department of Otolaryngology - Head and Neck Surgery, Baylor College of Medicine, United States.

Although many studies have reported on tests of the vestibular system a valid and reliable, evidence-based screening battery for easy clinical use remains elusive. Many screening tests attempt to assess the vestibulo-ocular reflex. Therefore, head shaking, the Dix-Hallpike maneuver, the supine roll test and head impulse tests are discussed. Read More

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http://dx.doi.org/10.1152/jn.00819.2018DOI Listing

Motorcycle helmet visor-related facial injury and its potential mechanism of injury: Evidence-based case study.

Traffic Inj Prev 2019 Apr 17:1-4. Epub 2019 Apr 17.

b Monash University Accident Research Centre (MUARC), Monash University , Victoria , Australia.

Objectives: We encountered an unusual facial laceration wound in relation to motorcycle helmet visor use during our clinical practice. We aimed to assess the prevalence of this unusual facial injury among motorcyclists who sustained facial injuries in selected hospitals and to determine the possible mechanism involved.

Methods: We used our prospective cross-sectional substudy involving injured motorcyclists presenting at major trauma hospitals in Southern Klang Valley, Malaysia, between March 2010 and March 2011. Read More

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http://dx.doi.org/10.1080/15389588.2018.1557640DOI Listing

Influence of Axial Length on Parafoveal and Peripapillary Metrics from Swept Source Optical Coherence Tomography Angiography.

Curr Eye Res 2019 Apr 17. Epub 2019 Apr 17.

a Department of Ophthalmology , 1st affiliated hospital of Xi'an Jiaotong University , Xi'an , Shaanxi , China .

Purpose: To assess the effect of axial length (AL) on the quantification of superficial vessel density of both macular and disc region using swept source optical coherence tomography angiography (SSOCTA).

Methods: This is a cross-sectional clinical study. Seventy-five eyes from 75 Chinese healthy participants (56 females) with a mean age of 26. Read More

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http://dx.doi.org/10.1080/02713683.2019.1607393DOI Listing

International comparisons of autism spectrum disorder behaviors in preschoolers rated by parents and caregivers/teachers.

Autism 2019 Apr 17:1362361319839151. Epub 2019 Apr 17.

2 University of Vermont, USA.

This study tested international similarities and differences in scores on a scale comprising 12 items identified by international mental health experts as being very consistent with the Diagnostic and Statistical Manual of Mental Disorders (5th ed.) category of autism spectrum disorder. Participants were 19,850 preschoolers in 24 societies rated by parents on the Child Behavior Checklist for Ages 1½-5; 10,521 preschoolers from 15 societies rated by caregivers/teachers on the Caregiver-Teacher Report Form, and 7380 children from 13 societies rated by both types of informant. Read More

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http://dx.doi.org/10.1177/1362361319839151DOI Listing

Comparison of postoperative voice outcomes after postauricular facelift robotic hemithyroidectomy and conventional transcervical hemithyroidectomy.

Head Neck 2019 Apr 17. Epub 2019 Apr 17.

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Republic of Korea.

Background: The purpose of this study was to determine whether postauricular robotic and conventional hemithyroidectomy result in significantly different voice outcomes.

Methods: We prospectively compared the voice handicap index (VHI)-10 and acoustic parameters of a postauricular facelift robotic group and a conventional group preoperatively, 1 week, 1 month, and 6 months after surgery.

Results: Forty-two patients in the postauricular group and 68 patients in the conventional group completed the VHI-10 questionnaire and acoustic analysis. Read More

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http://dx.doi.org/10.1002/hed.25777DOI Listing

Capsulotomy in Unstable Slipped Capital Femoral Epiphysis and the Odds of AVN: A Meta-Analysis of Retrospective Studies.

J Pediatr Orthop 2019 Apr 15. Epub 2019 Apr 15.

Hospital for Special Surgery, New York, NY.

Background: Unstable slipped capital femoral epiphysis (SCFE) may lead to avascular necrosis (AVN) in up to 60% of patients. The aim of this study was to assess the best clinical evidence to determine the effect of capsular decompression (CD) on odds of AVN in unstable SCFE.

Methods: Medline, Embase, and Cochrane databases were systematically searched for comparative studies investigating AVN rates in unstable SCFE treated with or without CD (aspiration, percutaneous, or open). Read More

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http://dx.doi.org/10.1097/BPO.0000000000001359DOI Listing

Primary Petrous Apex Epidermoids With Skull Base Erosion.

Otol Neurotol 2019 Apr 10. Epub 2019 Apr 10.

Division of Otolaryngology - Head and Neck Surgery, University of Utah, Salt Lake City, Utah.

Objective: To describe the clinical course and treatment outcomes for patients with petrous apex epidermoid with skull base erosion.

Study Design: Retrospective case series.

Setting: Tertiary-care academic center. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002199DOI Listing
April 2019
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Hearing Protection, Restoration, and Regeneration: An Overview of Emerging Therapeutics for Inner Ear and Central Hearing Disorders.

Otol Neurotol 2019 Apr 10. Epub 2019 Apr 10.

Department of Otolaryngology Head and Neck Surgery, Hannover Medical School, Hannover.

Objective: To provide an overview of biotechnology and pharmaceutical companies active in the field of inner ear and central hearing disorders and their therapeutic approaches.

Methods: Scientific and grey literature was searched using broad search terms to identify companies and their hearing-related therapeutic approaches. For each approach its lead indication, product, therapeutic modality, target, mechanism of action and current phase of clinical development was collated. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002194DOI Listing

Diagnostic Significance of HRAS Mutations in Epithelial-Myoepithelial Carcinomas Exhibiting a Broad Histopathologic Spectrum.

Am J Surg Pathol 2019 Apr 15. Epub 2019 Apr 15.

Departments of.

Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that is histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells. Because of its histologic variety, it is sometimes challenging to make an accurate diagnosis, and useful ancillary tests are essential for this purpose. We investigated 87 cases of EMC arising in the major and minor salivary glands and seromucinous glands in the nasal cavity or bronchus to describe the histologic features and mutation status of selected key oncogenes. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001258DOI Listing

A virtual burrow assay for head-fixed mice measures habituation, discrimination, exploration and avoidance without training.

Elife 2019 Apr 17;8. Epub 2019 Apr 17.

Department of Neuroscience, Howard Hughes Medical Institute, Columbia University, New York, United States.

We have designed an assay that measures approach and avoidance behaviors in head-fixed mice at millisecond timescale, is compatible with standard electrophysiological and optical methods for measuring neuronal activity, and requires no training. The Virtual Burrow Assay simulates a scenario in which a mouse, poised at the threshold of its burrow, evaluates whether to exit the enclosure or to retreat inside. The assay provides a sensitive readout of habituation, discrimination and exploration, as well as avoidance of both conditioned and innately aversive cues. Read More

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http://dx.doi.org/10.7554/eLife.45658DOI Listing

[The characteristics of soil water and gas transport under different land use patterns in the water-wind erosion crisscross region].

Ying Yong Sheng Tai Xue Bao 2019 Apr;30(4):1415-1422

State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau, Institute of Soil and Water Conservation, Chinese Academy of Sciences and Ministry of Water Resources, Yangling 712100, Shaanxi, China.

Understanding the effects of land use patterns on soil water and gas transport in the water-wind erosion crisscross region can provide guidance for high-efficiency use of limited soil and water resource in the ecological rehabilitation process on the Loess Plateau. To investigate the cha-racteristics of soil water and gas transport under different land use patterns and to study the relationships between soil saturated hydraulic conductivity (K), air permeability (K) and relative gas diffusivity (D/D), we collected soil samples (0-5 cm depth) from Caragana korshinskii land, abandoned land, alfalfa land, cropland, and bare land. K was measured by constant-head method. Read More

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http://dx.doi.org/10.13287/j.1001-9332.201904.040DOI Listing

Comparison of GPU Reconstruction based on Different Symmetries for Dual-head PET.

Med Phys 2019 Apr 17. Epub 2019 Apr 17.

Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710071, China.

Purpose: Dual-head positron emission tomography (PET) scanners have increasingly attracted the attention of many researchers. However, with the compact geometry, the depth-of-interaction (DOI) blurring will reduce the image resolution considerably. Monte Carlo (MC) based system response matrix (SRM) is able to describe the physical process of PET imaging accurately and improve reconstruction quality significantly. Read More

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http://dx.doi.org/10.1002/mp.13529DOI Listing

Medical Information Commons to Support Learning Healthcare Systems: Examples From Canada.

J Law Med Ethics 2019 Mar;47(1):97-105

Tania Bubela, Ph.D., J.D., F.C.A.H.S., is an expert in health and intellectual property law and policy, combining her training in genetics (Ph.D. Biology, University of Sydney) and law (Gold medalist, University of Alberta). She is the Dean of Faculty of Health Sciences at Simon Fraser University (Burnaby, British Columbia), developing sector-leading policies, processes, practices, and infrastructure to support excellence in interdisciplinary education, research, and engagement that will improve health, health equity, and well-being. Shelagh K. Genuis, Ph.D., is the project manager for the Genome Canada's Precision Medicine Policy Network, based in the Faculty of Medicine and Dentistry at the University of Alberta, Alberta. Naveed Z. Janjua, M.D., Ph.D., is a Senior Scientist at the BC Centre for Disease Control and Clinical Associate Professor at School of Population and Public Health, University of British Columbia. Mel Krajden, M.D., F.R.C.P.C., is the Director of BC's Public Health Laboratory and the Medical Head, Hepatitis at the British Columbia Centre for Disease Control. He is also a Professor of Pathology and Laboratory Medicine at the University of British Columbia. He has extensive clinical trials expertise and is a Co-investigator/Mentor on the CIHR funded National Research Training Program (CanHepC). Nicole Mittmann, Ph.D., is the Chief Research Officer at CCO. She is an Assistant Professor at the University of Toronto in the Department of Pharmacology and Toxicology and an Associate Scientist at Sunnybrook Health Sciences Centre. Katerina Podolak is the Group Manager for Data Acquisition and Disclosure at Cancer Care Ontario, working with data partners to bring data into CCO, and health system partners who want access to CCO data. Katerina has extensive experience with information management in the hospital setting, as well as Ontario's Ministry of Health and Long-term Care. Larry Svenson, Ph.D., F.R.S.P.H., is the Provincial Health Analytics Officer and Executive Director for Analytics and Performance Reporting at Alberta Health. He is also an Associate Professor with the Division of Preventive Medicine at the University of Alberta and an Adjunct Professor with the School of Public Health at the University of Alberta and the Cumming School of Medicine at the University of Calgary.

We explore how principles predicting the success of a medical information commons (MIC) advantaged or disadvantaged three MIC initiatives in three Canadian provinces. Our MIC case examples demonstrate that practices and policies to promote access to and use of health information can help improve individual healthcare and inform a learning health system. MICs were constrained by heterogenous health information protection laws across jurisdictions and risk-averse institutional cultures. Read More

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http://dx.doi.org/10.1177/1073110519840488DOI Listing

What's new in perinatal psychiatry?

Australas Psychiatry 2019 Apr;27(2):109-110

Medical Unit Head, Helen Mayo House, Womens and Childrens Health Network, South Australia, Clinical Senior Lecturer, University of Adelaide, Adelaide, SA, Australia.

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http://dx.doi.org/10.1177/1039856219833838DOI Listing

Healthcare educational leadership in the twenty-first century.

Authors:
Davinder Sandhu

Med Teach 2019 Apr 17:1-5. Epub 2019 Apr 17.

a Head of School of Postgraduate Studies and Research, Royal College of Surgeons in Ireland , Medical University of Bahrain , Adliya , Bahrain.

Education leadership has to intimately lead our future champions of students and nurture them as professional, dynamic, reflective scholars to deal with the complex world of healthcare in a post-truth era. In addition the organization structure needs to develop faculty from clinical and educational supervisors through to program directors and Deans. Leadership theories have taken over from the previous decades of teaching on management. Read More

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http://dx.doi.org/10.1080/0142159X.2019.1595555DOI Listing

Response of Glucocorticoid Receptor Alpha and Histone Deacetylase 2 to Glucocorticoid Treatment Predicts the Prognosis of Sudden Sensorineural Hearing Loss.

Clin Exp Otorhinolaryngol 2019 Mar 27. Epub 2019 Mar 27.

Department of Otolaryngology-Head and Neck Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing City, China.

Objectives: To investigate glucocorticoid receptor (GR) and histone deacetylase 2 (HDAC2) gene expression and protein levels in peripheral blood mononuclear cells (PBMCs) of patients with severe or profound sudden sensorineural hearing loss (SSNHL) and to explore the roles of GRs and HDAC2 in glucocorticoid (GC) insensitivity.

Methods: Fifty-five severe or profound SSNHL patients were enrolled in the study. According to hearing improvement after GC treatment, patients were assigned into two groups: GC-sensitive and GC-resistant. Read More

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http://dx.doi.org/10.21053/ceo.2018.01298DOI Listing

Mouse Extraocular Muscles and the Musculotopic Organization of their Innervation.

Anat Rec (Hoboken) 2019 Apr 16. Epub 2019 Apr 16.

Departments of Neurobiology & Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.

The organization of extraocular muscles and their motor nuclei was investigated in the mouse due to the increased importance of this model for oculomotor research. Mice showed a standard extraocular muscle organization pattern, although their eyes are set at the side of the head. They do have more prominent oblique muscles, whose insertion points differ from those of frontal-eyed species. Read More

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http://dx.doi.org/10.1002/ar.24141DOI Listing

An evaluation of an early stage innovation for full-thickness excision of benign colonic polyps using the IDEAL framework.

Colorectal Dis 2019 Apr 16. Epub 2019 Apr 16.

Department of Surgery, St Mark's Hospital, Harrow, Middlesex, UK.

Aims: Colectomy is the current approach for patients with endoscopically unresectable benign polyps but risks considerable morbidity. Full-thickness laparoendoscopic excision(FLEX) is a novel, specifically developed procedure which could reduce this treatment burden and improve outcomes. However, traditional evaluations of surgical innovations have lacked methodological rigour. Read More

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http://dx.doi.org/10.1111/codi.14650DOI Listing

Nonrecurrent laryngeal nerve in thyroid surgery: Frequency, anatomical variations according to a new classification and surgery consideration.

Head Neck 2019 Apr 17. Epub 2019 Apr 17.

Department of Head and Neck Surgery, Vietnam National Cancer Hospital, Hanoi, Vietnam.

Background: The nonrecurrent laryngeal nerve (NRLN) is a rare embryologically derived variant of the RLN. We aimed to identify the proportion of NRLN (during thyroidectomy), classify clinical NRLN types, and recommend some surgical considerations.

Method: In this prospective study, from May 2017 to September 2018, our hospital carried out 2158 thyroid operations. Read More

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http://dx.doi.org/10.1002/hed.25771DOI Listing

Does drug-induced sleep endoscopy affect surgical outcome? A multicenter study of 326 obstructive sleep apnea patients.

Laryngoscope 2019 Apr 17. Epub 2019 Apr 17.

Otolaryngology Department, Western University, London, Ontario, Canada.

Objectives/hypothesis: Our objective was to determine whether drug-induced sleep apnea (DISE) affects the successfulness of the surgical outcome.

Study Design: Prospective, seven-country, nonrandomized trial.

Methods: There were 326 consecutive obstructive sleep apnea (OSA) patients who had nose, palate, and/or tongue surgery included in the study. Read More

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http://dx.doi.org/10.1002/lary.27987DOI Listing

Habitat use and vestibular system's dimensions in lacertid lizards.

J Anat 2019 Apr 17. Epub 2019 Apr 17.

Department of Biology, Laboratory of Functional Morphology, University of Antwerp, Antwerp, Belgium.

The vestibular system is crucial for movement control during locomotion. As the dimensions of the vestibular system determine the fluid dynamics of the endolymph and, as such, the system's function, we investigate the interaction between vestibular system size, head size and microhabitat use in lizards. We grouped 24 lacertid species in three microhabitat types, we acquired three-dimensional models of the bony vestibular systems using micro-computer tomography scanning, and we performed linear and surface measurements. Read More

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http://dx.doi.org/10.1111/joa.12993DOI Listing
April 2019
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Long noncoding RNA PTPRG-AS1 acts as a microRNA-194-3p sponge to regulate radiosensitivity and metastasis of nasopharyngeal carcinoma cells via PRC1.

J Cell Physiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Otolaryngology, Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.

Protein regulator of cytokinesis 1 (PRC1) has been reported in correlation with various malignancies. Functionality of PRC1 in nasopharyngeal carcinoma (NPC) was investigated, in perspective of long noncoding RNA (lncRNA) regulatory circuitry. Aberrant expressed messenger RNA and lncRNA were screened out from the Gene Expression Omnibus microarray database. Read More

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http://dx.doi.org/10.1002/jcp.28547DOI Listing

Sarcomas of the mandible.

J Surg Oncol 2019 Apr 16. Epub 2019 Apr 16.

Department of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, New York.

Introduction: Sarcomas of the mandible are extremely rare tumors, with osteosarcoma being the most common, followed by Ewing's sarcoma MATERIALS AND METHODS: A retrospective review of the clinical records, imaging studies, and pathology slides of patients with sarcoma of the mandible at a Tertiary Care Cancer Center from 1998 to 2014 was undertaken. The impact of neoadjuvant chemotherapy and postoperative radiotherapy with or without chemotherapy was studied, and factors impacting upon local control and disease-specific survival were analyzed.

Results: Twenty-two patients were treated over the study period, comprising of 15 males and seven females. Read More

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http://dx.doi.org/10.1002/jso.25477DOI Listing

Evaluation of reference genes for quantitative real-time PCR analysis of messenger RNAs and microRNAs in rainbow trout Oncorhynchus mykiss under heat stress.

J Fish Biol 2019 Apr 16. Epub 2019 Apr 16.

College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, China.

We assessed the expression stability of several messenger (m)RNAs and micro (mi)RNAs from liver and head kidney of rainbow trout Oncorhynchus mykiss using high-throughput RNA sequencing (RNA-seq) and miRNA-seq data. Additionally, four commonly used reference genes and one small non-coding RNA (u6) were also selected to identify ideal reference mRNAs and miRNAs for quantitative real-time (qrt)-PCR analysis of heat stress responses. GeNorm, NormFinder, BestKeeper and comparative ΔC were employed for analysis of qrt-PCR data to systematically assess the expression stability of candidate mRNAs and miRNAs and stability was ranked using geometric means. Read More

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http://dx.doi.org/10.1111/jfb.13986DOI Listing

A qualitative study investigating the meaning of participation to improve the measurement of this construct.

Qual Life Res 2019 Apr 16. Epub 2019 Apr 16.

Coronel Institute of Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, AMC, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

Purpose: The purpose of this study was to improve the measurement of participation. Research questions were as follows: (1) What constitutes participation according to adults? (2) Do they mention participation subdomains that are not covered in the Patient-Reported Outcomes Measurement Information System (PROMIS) item bank "Ability to Participate in Social Roles and Activities"?

Methods: Semi-structured interviews were conducted with 46 adults from the general population. Interviews were thematically analysed using the International Classification of Functioning, Disability and Health (ICF) as conceptual framework. Read More

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http://dx.doi.org/10.1007/s11136-019-02179-9DOI Listing

A preclinical evaluation of thiostrepton, a natural antibiotic, in nasopharyngeal carcinoma.

Invest New Drugs 2019 Apr 16. Epub 2019 Apr 16.

Department of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, No.201, Sec.2, Shipai Road, Taipei, 112, Taiwan.

Background Thiostrepton, a natural antibiotic, has recently been shown to be a potential anticancer drug for certain cancers, but its study in nasopharyngeal carcinoma (NPC) is still limited. The aims of this study were to investigate the anticancer effect of thiostrepton on NPC cells and to explore its underlying mechanism. Methods The effects of thiostrepton on the proliferation, migration, and invasion of NPC cells were investigated by a WST-1 assay, wound healing assay, and cell invasion assay, respectively. Read More

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http://link.springer.com/10.1007/s10637-019-00779-3
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http://dx.doi.org/10.1007/s10637-019-00779-3DOI Listing
April 2019
1 Read

Feasibility and usefulness of endoscopic ultrasonography-guided shear-wave measurement for assessment of autoimmune pancreatitis activity: a prospective exploratory study.

J Med Ultrason (2001) 2019 Apr 16. Epub 2019 Apr 16.

Department of Gastorenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.

Purpose: To assess the feasibility and the clinical usefulness of a newly developed endoscopic ultrasonography (EUS) shear-wave elastography technique (EUS shear-wave measurement: EUS-SWM) in the diagnosis and treatment of autoimmune pancreatitis (AIP).

Methods: Tissue elasticity was measured in the pancreas in 160 patients. The success rate of EUS-SWMs, the velocity of the shear wave (Vs, m/s), and the reliability index of the Vs measurement (VsN) were evaluated, and the elasticity (median Vs) was compared between AIP patients (n = 14) and normal controls. Read More

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http://dx.doi.org/10.1007/s10396-019-00944-4DOI Listing

Update in Neurocritical Care: a summary of the 2018 Paris international conference of the French Society of Intensive Care.

Ann Intensive Care 2019 Apr 16;9(1):47. Epub 2019 Apr 16.

Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, 1070, Brussels, Belgium.

The 2018 Paris Intensive Care symposium entitled "Update in Neurocritical Care" was organized in Paris, June 21-22, 2018, under the auspices of the French Intensive Care Society. This 2-day post-graduate educational symposium comprised several chapters, aiming first to provide all-board intensivists with current standards for the clinical assessment of altered consciousness states (including coma and delirium) and peripheral nervous system in critically ill patients, monitoring of brain function (specifically, electro-encephalography) and best practices for sedation-analgesia-delirium management. An update on the treatment of specific severe brain pathologies-including ischaemic/haemorrhagic stroke, cerebral venous thrombosis, hypoxic-ischaemic brain injury, immune-mediated and infectious encephalitis and refractory status epilepticus-was also provided. Read More

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http://dx.doi.org/10.1186/s13613-019-0523-xDOI Listing

Pedicle screw navigation using surface digitization on the Microsoft HoloLens.

Int J Comput Assist Radiol Surg 2019 Apr 15. Epub 2019 Apr 15.

Computer Assisted Research and Development Group, Balgrist University Hospital, University of Zurich, Forchstrasse 340, 8008, Zurich, Switzerland.

Purpose: In spinal fusion surgery, imprecise placement of pedicle screws can result in poor surgical outcome or may seriously harm a patient. Patient-specific instruments and optical systems have been proposed for improving precision through surgical navigation compared to freehand insertion. However, existing solutions are expensive and cannot provide in situ visualizations. Read More

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http://dx.doi.org/10.1007/s11548-019-01973-7DOI Listing

Barbed suspension pharyngoplasty for treatment of lateral pharyngeal wall and palatal collapse in patients affected by OSAHS.

Eur Arch Otorhinolaryngol 2019 Apr 16. Epub 2019 Apr 16.

IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Purpose: The aim of this study is to analyze the efficacy of a new modified pharyngoplasty technique with barbed sutures: barbed suspension pharyngoplasty (BSP).

Methods: We enrolled patients affected by obstructive sleep apnea-hypopnea syndrome (OSAHS), having the main site of obstruction at the palatal and lateral pharyngeal walls, who refused or failed to tolerate CPAP therapy and underwent non-resective pharyngoplasty with barbed sutures between January 2014 and October 2017. Two surgical techniques with barbed sutures were used: barbed reposition pharyngoplasty (BRP) and BSP; the main characteristics of the latter are a double passage of the needle, each side, through the soft palate. Read More

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http://dx.doi.org/10.1007/s00405-019-05426-4DOI Listing

Endoscopic transvestibular anatomy of the infratemporal fossa and upper parapharyngeal spaces for clinical surgery: a cadaver study.

Eur Arch Otorhinolaryngol 2019 Apr 16. Epub 2019 Apr 16.

Department of Otorhinolaryngology-Head and Neck Surgery (Shanghai Key Clinical Disciplines of Otorhinolaryngology), Eye, Ear, Nose and Throat Hospital, Fudan University, Fenyang Road Num83, Xuhui District, Shanghai, 200031, China.

Aims: To investigate the anatomy of the infratemporal fossa (ITF) and to discuss the practicality of endoscopic transvestibular surgery for an ITF tumor.

Methods: Five fresh cadaveric specimens (10 sides) with vascular silicone injection were prepared for endoscopic anatomy. A transvestibular vertical incision was made along the ramus of the mandible, and pivotal nerves, arteries, and muscles were exposed to sculpt the anatomic landmarks of the ITF. Read More

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http://dx.doi.org/10.1007/s00405-019-05410-yDOI Listing

Assessing quality of life in palliative care settings: head-to-head comparison of four patient-reported outcome measures (EORTC QLQ-C15-PAL, FACT-Pal, FACT-Pal-14, FACT-G7).

Support Care Cancer 2019 Apr 16. Epub 2019 Apr 16.

Deakin Health Economics, Institute for Health Transformation, School of Health and Social Development, Faculty of Health, Deakin University, Geelong, Victoria, Australia.

Purpose: Head-to-head comparison of reliability, validity and responsiveness of four patient-reported outcome measures (PROMS) suitable for assessing health-related quality of life (HRQOL) in palliative care settings: EORTC QLQ-C15-PAL, FACT-G7, FACIT-Pal and short-form FACIT-Pal-14.

Methods: Secondary analysis of two phase III randomised trials: ketamine for chronic cancer pain, octreotide for vomiting in inoperable malignant bowel obstruction. Sub-groups were defined by Australia-modified Karnofsky performance status (AKPS) and participants' global impression of change (GIC). Read More

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http://dx.doi.org/10.1007/s00520-019-04754-9DOI Listing

Health-related and cancer-related Internet use by patients treated with total laryngectomy.

Support Care Cancer 2019 Apr 16. Epub 2019 Apr 16.

Department of Clinical, Neuro- and Developmental Psychology, Faculty of Behavioral and Movement Sciences, Amsterdam Public Health research institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Objectives: To investigate among patients treated with a total laryngectomy (TL) (1) Internet-use and Internet use to search for information on health and cancer (content); (2) which patients are most likely to use the Internet in general, for health-related and cancer-related purposes; (3) which other types of eHealth (community, communication, care) are used; and (4) preferences towards future use.

Methods: Patient members of the Dutch TL patient society were asked to complete a questionnaire on Internet use, health-related and cancer-related Internet use, types of eHealth, preferences towards future use, socio-demographics, clinical factors, and quality of life (QOL). Factors associated with Internet use and health-related and cancer-related Internet use were investigated using stepwise logistic regression analysis. Read More

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http://link.springer.com/10.1007/s00520-019-04757-6
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http://dx.doi.org/10.1007/s00520-019-04757-6DOI Listing
April 2019
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Reply to Letter to the Editor Regarding "The Importance of Diagnosing Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) Based on the Defined Criteria".

Ann Surg Oncol 2019 Apr 16. Epub 2019 Apr 16.

Department of Otolaryngology - Head and Neck Surgery/Surgical Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1245/s10434-019-07358-zDOI Listing

Pharmacological intervention in the field of ototoxicity.

Authors:
G Laurell

HNO 2019 Apr 16. Epub 2019 Apr 16.

Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Uppsala University, Akademiska sjukhuset ing 78-79, 75185, Uppsala, Sweden.

Modern research on ototoxicity goes back to the 1940s, when streptomycin was introduced into clinical practice. Today, aminoglycoside antibiotics and platinum-based chemotherapy, mainly cisplatin, are the most important drugs that damage the inner ear and cause hearing loss. The mode of drug administration as well as drug characteristics influence the likelihood that adequate monitoring of drug pharmacokinetics can be performed. Read More

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http://dx.doi.org/10.1007/s00106-019-0663-1DOI Listing

Independent validation of tumour volume, cancer stem cell markers and hypoxia-associated gene expressions for HNSCC after primary radiochemotherapy.

Clin Transl Radiat Oncol 2019 May 18;16:40-47. Epub 2019 Mar 18.

German Cancer Consortium (DKTK) Partner Site Dresden, Germany and German Cancer Research Center (DKFZ), Heidelberg, Germany.

Objective: To independently validate the impact of tumour volume, p16 status, cancer stem cell (CSC) marker expression and hypoxia-associated gene signatures as potential prognostic biomarkers for patients with locally advanced head and neck squamous cell carcinoma (HNSCC), who underwent primary radiotherapy or radiochemotherapy (RCTx). These markers have previously been reported in a study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG) (Linge et al., 2016). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24056308183011
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http://dx.doi.org/10.1016/j.ctro.2019.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449705PMC
May 2019
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Perspectives on the Social, Physical, and Emotional Impact of Living With Perthes' Disease in Children and Their Family: A Mixed Methods Study.

Glob Pediatr Health 2019 4;6:2333794X19835235. Epub 2019 Apr 4.

University of Liverpool, Liverpool, UK.

. To determine the social, physical, and emotional impact of living with Perthes' disease on affected children and their family (caregivers). . Read More

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http://dx.doi.org/10.1177/2333794X19835235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449807PMC
April 2019
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Oral Health Status and Oral Health-related Quality of Life According to Presence or Absence of Mucositis in Head and Neck Cancer Patients.

J Cancer Prev 2019 Mar 30;24(1):43-47. Epub 2019 Mar 30.

Department of Dentistry, Kyungpook National University Chilgok Hospital, Daegu, Korea.

Background: Oral mucositis during radiotherapy which is harmful to the patients with head and neck is suggested to be related to the oral hygiene and health. Therefore, we evaluated the oral health status in relation to the occurrence of mucositis among patients with head and neck cancer during radiotherapy.

Methods: Tooth plaque index (PI), periodontal depth, and oral mucositis in 50 patients with head and neck cancer were examined by a dentist for 8 weeks after radiotherapy initiation. Read More

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http://dx.doi.org/10.15430/JCP.2019.24.1.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453589PMC

Osteonecrosis of the femoral head: pathophysiology and current concepts of treatment.

EFORT Open Rev 2019 Mar 15;4(3):85-97. Epub 2019 Mar 15.

Clinic of Orthopaedics and Trauma Surgery, Geneva University Hospitals, Geneva, Switzerland.

Osteonecrosis of the femoral head is a disabling pathology affecting a young population (average age at treatment, 33 to 38 years) and is the most important cause of total hip arthroplasty in this population. It reflects the endpoint of various disease processes that result in a decrease of the femoral head blood flow.The physiopathology reflects an alteration of the vascularization of the fine blood vessels irrigating the anterior and superior part of the femoral head. Read More

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http://dx.doi.org/10.1302/2058-5241.4.180036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440301PMC

Bayesian Analysis of Three-Parameter Frechet Distribution with Medical Applications.

Comput Math Methods Med 2019 12;2019:9089856. Epub 2019 Mar 12.

Faculty of Basic Sciences and Humanities, University of Engineering and Technology, Taxila, Pakistan.

The medical data are often filed for each patient in clinical studies in order to inform decision-making. Usually, medical data are generally skewed to the right, and skewed distributions can be the appropriate candidates in making inferences using Bayesian framework. Furthermore, the Bayesian estimators of skewed distribution can be used to tackle the problem of decision-making in medicine and health management under uncertainty. Read More

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http://dx.doi.org/10.1155/2019/9089856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434294PMC

The Significant Influence of the Neuroendocrine Component on the Survival of Patients with Gastric Carcinoma Characterized by Coexisting Exocrine and Neuroendocrine Components.

J Oncol 2019 12;2019:3671268. Epub 2019 Mar 12.

Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Background: Gastric adenocarcinoma patients with a neuroendocrine (NE) component are frequently observed in routine practice. Several previous studies have investigated the influence of a NE component on the survival of these patients; however, the results were inconsistent.

Methods: We retrospectively investigated a consecutive series of 95 gastric adenocarcinoma patients with a NE component and 190 gastric adenocarcinoma patients without a NE component. Read More

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http://dx.doi.org/10.1155/2019/3671268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434268PMC

Long-term Breastfeeding in the Prevention of Allergic Rhinitis: Allergic Rhinitis Cohort Study for Kids (ARCO-Kids Study).

Clin Exp Otorhinolaryngol 2019 Apr 18. Epub 2019 Apr 18.

Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul, Korea.

Objectives: There is a great deal of interest in the possibility that environmental factors may influence the risk of developing allergic rhinitis (AR) in early life. We investigated the simultaneous effects of mode of delivery and duration of breastfeeding on the development of AR in children.

Methods: Data from 1,374 children participating in the Allergic Rhinitis Cohort Study for kids (ARCO-kids study) was analyzed. Read More

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http://dx.doi.org/10.21053/ceo.2018.01781DOI Listing
April 2019
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