609,833 results match your criteria Head & Face Medicine [Journal]


Neck muscle fatigue affects performance of an eye-hand tracking task.

J Electromyogr Kinesiol 2019 Apr 10;47:1-9. Epub 2019 Apr 10.

Faculty of Health Sciences, University of Ontario Institute of Technology, 2000 Simcoe St. North, Oshawa, ON L1H 7K4, Canada. Electronic address:

Altered afferent input from the neck due to fatigue alters upper limb proprioception and is likely to impact upper limb performance accuracy. This study examined the effect of cervical extensor muscle (CEM) fatigue on eye-hand tracking accuracy in healthy participants. Twenty-four healthy right-handed individuals were randomly assigned to either a control or CEM fatigue group. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10506411183048
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http://dx.doi.org/10.1016/j.jelekin.2019.04.001DOI Listing
April 2019
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Spatiotemporal gait parameters and tremor distribution in essential tremor.

Gait Posture 2019 Apr 14;71:32-37. Epub 2019 Apr 14.

University of Florida, Gainesville, FL, United States.

Background: Essential Tremor is characterized by an action tremor of the upper extremities, which may or may not be accompanied by a head, voice, leg or trunk tremor. Problems with gait and balance have also been identified in persons with Essential Tremor. Therefore, understanding gait performance is an important area of focus for clinicians and researchers. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2019.04.004DOI Listing

The effect of altered stride length on iliocapsularis and pericapsular muscles of the anterior hip: An electromyography investigation during asymptomatic gait.

Gait Posture 2019 Apr 10;71:26-31. Epub 2019 Apr 10.

The University of Queensland, School of Health & Rehabilitation Sciences, Brisbane, QLD, 4072, Australia; La Trobe Sport and Exercise Medicine Research Centre (LASEM), College of Science, Health and Engineering, School of Allied Health, La Trobe University, Melbourne, Victoria, Australia.

Background: Anterior pericapsular muscles potentially contribute to active hip joint stability in walking by controlling anterior femoral translation in peak extension. Alternatively, these muscles could flex the hip and tension the anterior capsule to aid initiation of swing. Although never investigated, the location of Iliocapsularis and its extensive anterior hip capsule attachment imply a potential role in these functions. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2019.04.003DOI Listing

Cost-Effectiveness of Sentinel Lymph Node Biopsy for Head and Neck Cutaneous Squamous Cell Carcinoma.

J Surg Res 2019 Apr 17;241:15-23. Epub 2019 Apr 17.

Division of Surgical Oncology, Department of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey. Electronic address:

Background: Sentinel lymph node biopsy (SLNB) has shown promise in identifying subclinical nodal metastasis in patients with high-risk cutaneous squamous cell carcinoma. However, low metastasis rates may indicate that performing such a procedure in all patients may be unnecessary and costly.

Materials And Methods: A decision model was developed to analyze costs and survival in patients with head and neck cutaneous squamous cell carcinoma based on their tumor and nodal metastasis staging and whether or not they received an SLNB. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.040DOI Listing

How to Transect the C2 Root for C1 lateral Mass Screw Placement: Case series and review of an under-appreciated variable in outcome.

World Neurosurg 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurosurgery, Maine Medical Center, Portland, Maine, USA.

Objective: The techniques for atlantoaxial arthrodesis have been modified over the years and placing C1 lateral mass screws is a modern approach.C2 neuropathy is a complication of concern although sacrifice of the C2 nerve is an accepted and often favored adjunct. The impact of the technique for cutting the C2 nerve is not adequately addressed in the literature. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.100DOI Listing

A new adhesive bone conduction hearing system effectively treats conductive hearing loss in children.

Int J Pediatr Otorhinolaryngol 2019 Apr 3;122:117-125. Epub 2019 Apr 3.

Department of Otorhinolaryngology, Head and Neck Surgery, St. Elisabeth-Hospital, Ruhr University Bochum, Bochum, Germany.

Objectives: Bone conduction hearing devices integrated in softbands (BCDSs) are frequently not well accepted by children with conductive hearing loss due to pressure on the head, sweating, or cosmetic stigma. A non-surgical hearing system (ADHEAR) uses a new bone conduction concept consisting of an audio processor connected to an adhesive adapter fixed behind the ear. This study is the first to evaluate the audiological and clinical outcome of this novel system, comparing it with conventional BCDSs in a short- and mid-term follow-up in children under 10 years of age. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.03.014DOI Listing

EUS versus Magnetic Resonance Imaging in Staging Rectal Adenocarcinoma: A Diagnostic Test Accuracy Meta-Analysis.

Gastrointest Endosc 2019 Apr 17. Epub 2019 Apr 17.

Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada; Gastrointestinal Health Technology Assessment Group, The Farncombe Family Digestive Health Research Institute, Hamilton, Ontario, Canada.

Backgrounds And Aims: EUS and magnetic resonance imaging (MRI) are both used for locoregional staging of rectal cancer, which determines treatment options. There is a lack of consensus on the best modality for locoregional staging, with studies supporting both EUS and MRI. In this study, we performed the first diagnostic test accuracy meta-analysis to compare the diagnostic accuracy, sensitivity, and specificity of EUS and MRI in the staging of rectal cancer. Read More

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http://dx.doi.org/10.1016/j.gie.2019.04.217DOI Listing

Evaluation of a Lectin-Based Imaging System for the Chairside Detection of Oral Dysplasia and Malignancy.

J Oral Maxillofac Surg 2019 Mar 26. Epub 2019 Mar 26.

Chief of Surgery, Chief and Fellowship Director, Oral and Maxillofacial Surgery, North Memorial Medical Center, Robbinsdale, MN. Electronic address:

Purpose: Currently available oral cancer screening adjuncts do not have enhanced clinical screening methods because of high false positives and negatives, highlighting the need for a molecularly specific technique for accurate screening of suspicious oral lesions. The purpose of this study was to evaluate the in vivo screening accuracy of an oral lesion identification system that evaluates aberrant glycosylation patterns using a fluorescently labeled lectin (wheat germ agglutinin and fluorescein isothiocyanate [WGA-FITC]).

Materials And Methods: The authors designed and implemented a prospective cohort study at 3 institutions composed of patients with and without suspicious oral lesions. Read More

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http://dx.doi.org/10.1016/j.joms.2019.03.012DOI Listing

Correlations between Computational Fluid Dynamics and clinical evaluation of nasal airway obstruction due to septal deviation: an observational study.

Clin Otolaryngol 2019 Apr 20. Epub 2019 Apr 20.

APHM, Department of Oto-Rhino-Laryngology and Head and Neck Surgery, La Conception University Hospital, 13385, Marseille Cedex, France.

Objectives: The primary objective of this study was to determine how Computational Fluid Dynamics (CFD) could be correlated to clinical evaluation of Nasal Airway Obstruction (NAO) in a population of patients with symptomatic septal deviation (SD). The secondary objective was to determine whether CFD could define which side was the more obstructed.

Design: This was an observational study. Read More

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http://dx.doi.org/10.1111/coa.13344DOI Listing

Changes of visualized Eustachian tube lengths by age and position: Radiologic study in sitting and supine positions using cone-beam and conventional CT.

Clin Otolaryngol 2019 Apr 20. Epub 2019 Apr 20.

Department of Otorhinolaryngology-Head & Neck Surgery, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Objectives: Patulous Eustachian tube (ET) has been characterized by the visualization of full length ET on computed tomography (CT) results. We wanted to investigate the changes of visualized ET lengths by age in supine and sitting positions.

Design: Retrospective study. Read More

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http://dx.doi.org/10.1111/coa.13342DOI Listing

Impact of noise-reduction schemes on quantitative accuracy of CT numbers.

Med Phys 2019 Apr 20. Epub 2019 Apr 20.

Department of Medical Physics, University of Wisconsin, School of Medicine and Public Health, 1111 Highland Avenue, Madison, WI, 53705, USA.

Purpose: In previous works, it has been demonstrated that for filtered backprojection (FBP) reconstruction based CT images, the measured CT numbers are biased and the bias level decreases with increasing radiation dose. Low dose scans typically include noise-reduction schemes to reduce noise level. The purpose of this work was to investigate the potential impact of different noise-reduction schemes on the CT number bias. Read More

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http://dx.doi.org/10.1002/mp.13549DOI Listing

Toward neuroimaging-based network biomarkers for transient ischemic attack.

Hum Brain Mapp 2019 Apr 19. Epub 2019 Apr 19.

Institute for Brain Research and Rehabilitation, Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for Studies of Psychological Application, South China Normal University, Guangzhou, China.

Stroke is associated with topological disruptions of large-scale functional brain networks. However, whether these disruptions occur in transient ischemic attack (TIA), an important risk factor for stroke, remains largely unknown. Combining multimodal MRI techniques, we systematically examined TIA-related topological alterations of functional brain networks, and tested their reproducibility, structural, and metabolic substrates, associations with clinical risk factors and abilities as diagnostic and prognostic biomarkers. Read More

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http://dx.doi.org/10.1002/hbm.24602DOI Listing

Defining the Role of Lymphadenectomy for Pancreatic Neuroendocrine Tumors: An Eight-Institution Study of 695 Patients from the US Neuroendocrine Tumor Study Group.

Ann Surg Oncol 2019 Apr 19. Epub 2019 Apr 19.

Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, GA, USA.

Background: Preoperative factors that reliably predict lymph node (LN) metastases in pancreatic neuroendocrine tumors (PanNETs) are unclear. The number of LNs needed to accurately stage PanNETs has not been defined.

Methods: Patients who underwent curative-intent resection of non-functional PanNETs at eight institutions from 2000 to 2016 were analyzed. Read More

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http://link.springer.com/10.1245/s10434-019-07367-y
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http://dx.doi.org/10.1245/s10434-019-07367-yDOI Listing
April 2019
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Characterization and genome analysis of a novel bacteriophage vB_SpuP_Spp16 that infects Salmonella enterica serovar pullorum.

Virus Genes 2019 Apr 19. Epub 2019 Apr 19.

College of Veterinary Medicine, Qingdao Agricultural University, Shandong, 266109, China.

A novel virulent bacteriophage vB_SpuP_Spp16 (hereafter designated Spp16) that infects Salmonella enterica serovar pullorum was isolated. Transmission electron microscopy showed that Spp16 possessed an isometric polyhedral head (60 nm in diameter) and a short tail (10 nm in length) belonging to the family Podoviridae. Its complete genome was determined to be 41,832 bp, with a 39. Read More

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http://dx.doi.org/10.1007/s11262-019-01664-0DOI Listing

Functional and oncological outcomes after retropharyngeal node dissection for papillary thyroid carcinoma.

Eur Arch Otorhinolaryngol 2019 Apr 19. Epub 2019 Apr 19.

Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-Ku, Kobe, Hyogo, 650-0017, Japan.

Background: Papillary thyroid carcinoma frequently metastasizes to central and lateral neck lymph nodes, but metastasis to retropharyngeal lymph nodes (RPLN) is rare.

Patients And Methods: We retrospectively reviewed 16 patients with RPLN metastasis of PTC who underwent therapeutic dissection of RPLN metastases.

Results: Among 16 patients, 7 patients underwent RPLN dissection with initial surgery and remaining 9 patients as salvage surgery. Read More

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http://dx.doi.org/10.1007/s00405-019-05420-wDOI Listing

A patient tumour-on-a-chip system for personalised investigation of radiotherapy based treatment regimens.

Sci Rep 2019 Apr 19;9(1):6327. Epub 2019 Apr 19.

Department of Biomedical Sciences, The University of Hull, Cottingham Road, Hull, UK.

Development of personalised cancer models to predict response to radiation would benefit patient care; particularly in malignancies where treatment resistance is prevalent. Herein, a robust, easy to use, tumour-on-a-chip platform which maintains precision cut head and neck cancer for the purpose of ex vivo irradiation is described. The device utilises sintered discs to separate the biopsy and medium, mimicking in vivo microvascular flow and diffusion, maintaining tissue viability for 68 h. Read More

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http://dx.doi.org/10.1038/s41598-019-42745-2DOI Listing

Nonsense mutation in causes normal-pressure hydrocephalus with ciliary abnormalities.

Neurology 2019 Apr 19. Epub 2019 Apr 19.

From the Departments of Neuropsychiatry (Y.M., N.Y., H.O.) and Otolaryngology-Head and Neck Surgery (C.S.), Unit of Translation Medicine, and Department of Human Genetics (S.Y., A.K., H.M., K.-i.Y., S.O.), Nagasaki University Graduate School of Biomedical Sciences; Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute (K.M., M.N.), Central Laboratory, Institute of Tropical Medicine (NEKKEN) (M.S.), and Gene Research Center, Center for Frontier Life Sciences (T.K.), Nagasaki University; Department of Infectious Diseases (T.T.) and Child and Adolescent Psychiatry Community Partnership Unit (A.I.), Nagasaki University Hospital; Department of Cell Pathology (Y.K.), Graduate School of Medical Sciences, Kumamoto University; and Department of Clinical Psychology, Faculty of Medicine (N.K.), Kagawa University, Takamatsu, Japan.

Objective: To identify genes related to normal-pressure hydrocephalus (NPH) in one Japanese family with several members with NPH.

Methods: We performed whole-exome sequencing (WES) on a Japanese family with multiple individuals with NPH and identified a candidate gene. Then we generated knockout mouse using CRISPR/Cas9 to confirm the effect of the candidate gene on the pathogenesis of hydrocephalus. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007505DOI Listing
April 2019
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A novel mutation in the gene expands the phenotype of Alexander disease.

J Med Genet 2019 Apr 19. Epub 2019 Apr 19.

Neurometabolic Diseases Laboratory, Institut d'Investigacio Biomedica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat (Barcelona), Catalonia, Spain

Background: Alexander disease, an autosomal dominant leukodystrophy, is caused by missense mutations in . Although mostly diagnosed in children, associated with severe leukoencephalopathy, milder adult forms also exist.

Methods: A family affected by adult-onset spastic paraplegia underwent neurological examination and cerebral MRI. Read More

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http://jmg.bmj.com/lookup/doi/10.1136/jmedgenet-2018-105959
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http://dx.doi.org/10.1136/jmedgenet-2018-105959DOI Listing
April 2019
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Head, heart or checklist? How self-reported decision-making strategies change according to speciality and grade: a cross-sectional survey of doctors.

Postgrad Med J 2019 Apr 19. Epub 2019 Apr 19.

Paediatric Surgery, Barts Health NHS Trust, London, UK.

Purpose: To identify and analyse variations in self-reported decision-making strategies between medical professionals of different specialty and grade.

Study Design: We conducted a cross-sectional survey of doctors of different specialities and grades at St. George's Hospital, London, UK. Read More

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http://dx.doi.org/10.1136/postgradmedj-2018-136184DOI Listing

Increasing incidence rates of oropharyngeal squamous cell carcinoma in Germany and significance of disease burden attributed to human papillomavirus.

Cancer Prev Res (Phila) 2019 Apr 19. Epub 2019 Apr 19.

Department of Otolaryngology, Head and Neck Surgery, University Hospital Cologne.

Increasing incidences of head and neck cancers and rising proportions of these associated with human papilloma virus (HPV), especially in the oropharynx, have been reported in international studies. So far, the trends and contribution of HPV to the number of newly diagnosed cases of oropharyngeal squamous cell carcinomas (OPSCC) in Germany are uncertain. We investigated HPV association and incidence rates in a cohort of consecutively included patients with OPSCC in Giessen 2000-2017, and compared our results with regional (Giessen and the federal state of Hesse), national (Germany) and international (USA) databases. Read More

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http://dx.doi.org/10.1158/1940-6207.CAPR-19-0098DOI Listing

"No-No" Head Tremor-A Nod to the Diagnosis.

Pediatr Neurol 2019 Mar 19. Epub 2019 Mar 19.

Department of Neurology and Neurophysiology, Temple Street Children's University Hospital, Dublin, Ireland; Academic Centre on Rare Diseases, School of Medicine and Medical Science, University College Dublin, Ireland.

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http://dx.doi.org/10.1016/j.pediatrneurol.2019.03.007DOI Listing

Platinum rechallenge in recurrent head and neck squamous cell carcinoma after primary chemoradiation.

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Apr 16. Epub 2019 Apr 16.

Head and Neck Oncology, Centre François Baclesse, Avenue du Général Harris, 14000 Caen, France; Radiotherapy Department, Centre Francois Baclesse, Caen, France.

Objective: To evaluate platinum rechallenge efficacy and tolerance in patients presenting recurrent head and neck squamous cell carcinoma (HNSCC) after platinum-based chemoradiation.

Materials And Methods: We retrospectively included all patients treated from 2007 to 2016 by platinum-based polychemotherapy for recurrence of HNSCC previously treated by primary or postsurgical platinum-based chemoradiation. The primary end-point was disease control rate (DCR) on platinum rechallenge. Read More

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http://dx.doi.org/10.1016/j.anorl.2019.04.007DOI Listing

Sydenham's Chorea.

J Emerg Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Emergency Medicine, UPMC Hamot, University of Pittsburgh Medical Center (UPMC), Erie, Pennsylvania.

Background: Sydenham's chorea is the most common acquired movement disorder of adolescence. This clinical manifestation of acute rheumatic fever has a clear and documented relationship with Group A streptococcal infections. The symptoms are involuntary choreiform movements that can affect the face and all extremities. Read More

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http://dx.doi.org/10.1016/j.jemermed.2019.02.012DOI Listing

Innervation of cervical carcinoma is mediated by cancer-derived exosomes.

Gynecol Oncol 2019 Apr 16. Epub 2019 Apr 16.

Sanford Research, Cancer Biology and Immunotherapy Group, 2301 East 60th St north, Sioux Falls, SD 57104, USA. Electronic address:

Objective: Recently, our laboratory identified sensory innervation within head and neck squamous cell carcinomas (HNSCCs) and subsequently defined a mechanism whereby HNSCCs promote their own innervation via the release of exosomes that stimulate neurite outgrowth. Interestingly, we noted that exosomes from human papillomavirus (HPV)-positive cell lines were more effective at promoting neurite outgrowth than those from HPV-negative cell lines. As nearly all cervical tumors are HPV-positive, we hypothesized that these findings would extend to cervical cancer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258193114
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http://dx.doi.org/10.1016/j.ygyno.2019.04.651DOI Listing
April 2019
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A Review on Automatic Facial Expression Recognition Systems Assisted by Multimodal Sensor Data.

Sensors (Basel) 2019 Apr 18;19(8). Epub 2019 Apr 18.

Swinburne Data Science Research Institute, Swinburne University of Technology, Hawthorn VIC 3122, Australia.

Facial Expression Recognition (FER) can be widely applied to various research areas, such as mental diseases diagnosis and human social/physiological interaction detection. With the emerging advanced technologies in hardware and sensors, FER systems have been developed to support real-world application scenes, instead of laboratory environments. Although the laboratory-controlled FER systems achieve very high accuracy, around 97%, the technical transferring from the laboratory to real-world applications faces a great barrier of very low accuracy, approximately 50%. Read More

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https://www.mdpi.com/1424-8220/19/8/1863
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http://dx.doi.org/10.3390/s19081863DOI Listing
April 2019
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SEPSIS SECONDARY TO DELAYED PRESENTATION OF NECROTISING FASCIITIS OF THE THIGH-PRESENTATION OF TWO CASES WITH A POOR OUTCOME.

J Long Term Eff Med Implants 2018 ;28(4):309-317

Trauma and Orthopaedic Department, Red Cross Hospital, Athens, Greece.

Necrotizing fasciitis is an extremely virulent form of infectious fasciitis. It affects skin, subcutaneous fat, and superficial and deep muscular fascia by rapidly progressive necrosis. We present two cases, a 54-year-old female patient and a 46-year-old male patient, who presented to the emergency department of our hospital 30 days and 14 days after the onset of symptoms, respectively, with progressively deteriorating pain and swelling of the thigh, accompanied by fever, nausea, sweating, shortness of breath, and sepsis. Read More

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http://dx.doi.org/10.1615/JLongTermEffMedImplants.2019030061DOI Listing
January 2018
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Superior Capsular Reconstruction for Massive Rotator Cuff Tear with Malunion of the Greater Tuberosity in a Young Patient: A Case Report and Review of the Literature.

J Long Term Eff Med Implants 2018 ;28(4):289-295

OhioHealth Orthopedic Surgeons, Grant Medical Center, Columbus, Ohio.

We describe a 37-year-old female treated with superior capsular reconstruction (SCR) for a nonfunctional rotator cuff in a patient with surgical malunion of the greater tuberosity of the proximal humerus. Despite initially improving, at one year follow-up the patient's acromiohumerual distance had narrowed and pain had increased, resulting in loss of motion. A nonfunctional rotator cuff in the setting of greater tuberosity malunion and superior humeral head migration may not be amenable to SCR. Read More

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http://dx.doi.org/10.1615/JLongTermEffMedImplants.2019029861DOI Listing
January 2018

Early Fracture of the Modular Femoral Neck Component in Total Hip Arthroplasty: A Case Report.

J Long Term Eff Med Implants 2018 ;28(4):267-270

Department of Orthopaedic Surgery, Maimonides Medical Center, Brooklyn, NY.

A 64-year-old man who had previously undergone total hip arthroplasty (THA) with the use of a dual modular (head and neck) total hip implant presented with a mechanical failure at the neck-stem junction three years after the index surgery with a low energy mechanism. The fractured stem was then removed, and a revision stem was implanted in order to restore the ability to ambulate for the patient. We demonstrate and contribute to the growing evidence of failure of modular THA systems at the neck-stem junction. Read More

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http://dx.doi.org/10.1615/JLongTermEffMedImplants.2019029606DOI Listing
January 2018
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Comprehensive anatomy of the foramen ovale critical to percutaneous stereotactic radiofrequency rhizotomy: cadaveric study of dry skulls.

J Neurosurg 2019 Apr 19:1-9. Epub 2019 Apr 19.

1Department of Neurosurgery, University of Minnesota, Minneapolis, Minnesota.

OBJECTIVEPercutaneous stereotactic radiofrequency rhizotomy (PSR) is often used to treat trigeminal neuralgia, a serious condition that results in lancinating, episodic facial pain. Thorough understanding of the microsurgical anatomy of the foramen ovale (FO) and its surrounding structures is required for efficient, effective, and safe use of this technique. This morphometric study compares anatomical and surgical orientations to identify the variations of the FO and assess cannulation difficulty. Read More

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http://dx.doi.org/10.3171/2019.1.JNS18899DOI Listing

Intraoperative monitoring of olfactory function: a feasibility study.

J Neurosurg 2019 Apr 19:1-6. Epub 2019 Apr 19.

2Faculty of Medicine, University of Geneva, Switzerland.

OBJECTIVEIntraoperative neuromonitoring of the chemical senses (smell and taste) has never been performed. The objective of this study was to determine if olfactory-evoked potentials could be obtained intraoperatively under general anesthesia.METHODSA standard olfactometer was used in the surgical theater with hydrogen sulfide (4 ppm, 200 msec). Read More

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https://thejns.org/view/journals/j-neurosurg/aop/article-10.
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http://dx.doi.org/10.3171/2019.1.JNS182731DOI Listing
April 2019
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Slow and steady wins the race: physical limits on the rate of viral DNA packaging.

Authors:
Paul J Jardine

Curr Opin Virol 2019 Apr 16;36:32-37. Epub 2019 Apr 16.

Department of Diagnostic and Biological Sciences, University of Minnesota, 18-242 Moos Tower, 515 Delaware St SE, Minneapolis, MN 55455, United States. Electronic address:

During the assembly of dsDNA viruses such as the tailed bacteriophages and herpesviruses, the viral chromosome is compacted to near crystalline density inside a preformed head shell. DNA translocation is driven by powerful ring ATPase motors that couple ATP binding, hydrolysis, and release to force generation and movement. Studies of the motor of the bacteriophage phi29 have revealed a complex mechanochemistry behind this process that slows as the head fills. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18796257183015
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http://dx.doi.org/10.1016/j.coviro.2019.03.002DOI Listing
April 2019
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Video-oculography eye tracking towards clinical applications: A review.

Comput Biol Med 2019 Mar 30;108:57-66. Epub 2019 Mar 30.

Research Institute for Signals, Systems and Computational Intelligence, Sinc(i), FICH-UNL/CONICET, Ruta Nac. No 168, Km 472.4 (3000), Santa Fe, Argentina.

Most neurological diseases are usually accompanied by a broad spectrum of oculomotor alterations. Being able to record and analyze these different types of eye movements would be a valuable tool to understand the functional integrity of brain structures. Nowadays, video-oculography is the most widely used eye-movements assessing method. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.03.025DOI Listing

A comprehensive assessment of stream fragmentation in Great Britain.

Sci Total Environ 2019 Apr 10;673:756-762. Epub 2019 Apr 10.

Department of Biosciences, College of Science, Swansea University, Swansea SA2 8PP, UK.

Artificial barriers are one of the main threats to river ecosystems, resulting in habitat fragmentation and loss of connectivity. Yet, the abundance and distribution of most artificial barriers, excluding high-head dams, is poorly documented. We provide a comprehensive assessment of the distribution and typology of artificial barriers in Great Britain, and estimate for the first time the extent of river fragmentation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193165
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http://dx.doi.org/10.1016/j.scitotenv.2019.04.125DOI Listing
April 2019
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Cisplatin: The first metal based anticancer drug.

Authors:
Sumit Ghosh

Bioorg Chem 2019 Apr 11;88:102925. Epub 2019 Apr 11.

Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh 208016, India. Electronic address:

Cisplatin or (SP-4-2)-diamminedichloridoplatinum(II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, ovarian, head and neck, bladder, lung, cervical cancer, melanoma, lymphomas and several others. Cisplatin exerts anticancer activity via multiple mechanisms but its most acceptable mechanism involves generation of DNA lesions by interacting with purine bases on DNA followed by activation of several signal transduction pathways which finally lead to apoptosis. However, side effects and drug resistance are the two inherent challenges of cisplatin which limit its application and effectiveness. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.102925DOI Listing
April 2019
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Dependence of resting-state fMRI fluctuation amplitudes on cerebral cortical orientation relative to the direction of B0 and anatomical axes.

Neuroimage 2019 Apr 16. Epub 2019 Apr 16.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 149 13th St., Charlestown, Boston, MA 02129, USA; Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, MA, USA. Electronic address:

Functional magnetic resonance imaging (fMRI) is now capable of sub-millimetre scale measurements over the entire human brain, however with such high resolutions each voxel is influenced by the local fine-scale details of the cerebral cortical vascular anatomy. The cortical vasculature is structured with the pial vessels lying tangentially along the grey matter surface, intracortical diving arterioles and ascending venules running perpendicularly to the surface, and a randomly oriented capillary network within the parenchyma. It is well-known that the amplitude of the blood-oxygenation level dependent (BOLD) signal emanating from a vessel depends on its orientation relative to the Bfield. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.04.036DOI Listing

Effect of symbiotic supplemented diet on innate-adaptive immune response, cytokine gene regulation and antioxidant property in Labeo rohita against Aeromonas hydrophila.

Fish Shellfish Immunol 2019 Apr 16. Epub 2019 Apr 16.

Department of Herbal and Environmental Science, Tamil University, Thanjavur, 613 005, Tamil Nadu, India.

Administration of probiotic, prebiotic or symbiotic supplemented diets boosts the antioxidant property, pro and/or anti-inflammatory cytokine gene transcription, innate-adaptive immunity, growth rate and feed digestibility with very low or no mortality in healthy and infected (both groups) in Labeo rohita against Aeromonas hydrophila is reported. The probiotic diet increased the white blood cell (WBC) count and globulin (GB) level significantly on or after 6th week whereas with the symbiotic diet the increase was noted two weeks earlier in both groups; the total protein (TP) level also increased significantly when fed with probiotic diet on weeks 6 and 8, whereas with symbiotic diet the significant increase manifested earlier at 4th week itself. The serum phagocytic activity (PA), respiratory burst activity (RBA), complement C3 (CC3) level, alternative complement pathway (ACP), lysozyme activity (LA), and immunoglobulin M (IgM) levels in head kidney (HK) leucocytes increased significantly (P < 0. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.04.036DOI Listing

(-)-α-Bisabolol reduces nociception and trigeminal central sensitisation in acute orofacial neuropathic pain induced by infraorbital nerve injury.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

Faculty of Dentistry, University of Toronto, Canada; Deparment of Physiology, University of Toronto, Canada.

Neuropathic orofacial pain conditions represent a challenge to diagnose and treat. Natural substances are promising therapeutic options for the control of pain.

Aims: This study aimed to examine whether (-)-α-bisabolol (BISA), a natural terpene, can attenuate nociceptive behaviour and central sensitisation in a rodent model of trigeminal neuropathic pain. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.032DOI Listing

Another case of coincidental Giardia infection and pancreatic cancer.

Parasitol Int 2019 Apr 16. Epub 2019 Apr 16.

Institute of Immunology and Microbiology, First Faculty of Medicine, Charles University, Prague, Czech Republic. Electronic address:

Until now, few cases of coincidental giardiasis and pancreatic tumors have been described. Among these cases, three described giardiasis cases coincided with confirmed pancreatic cancer. We present another case of Giardia infection coexisting with pancreatic cancer in a 67-year-old man who suffered from stenosis of the distal ductus choledochus combined with a hypoechoic mass in the head of the pancreas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13835769183035
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http://dx.doi.org/10.1016/j.parint.2019.04.013DOI Listing
April 2019
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The RAG2 gene of yellow catfish (Tachysurus fulvidraco) and its immune response against Edwardsiella ictaluri infection.

Dev Comp Immunol 2019 Apr 16. Epub 2019 Apr 16.

Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, China. Electronic address:

Recombination-activating gene 2 (rag 2) allies with recombination-activating gene 1 (rag 1) and regulates the V(D)J recombination of immunoglobulin (Ig) and T-cell receptor (TCR) genes. Being a key player in the adaptive immune response of vertebrates, functional characterization of rag 2 from yellow catfish is beneficial for understanding the biological response towards the pathogens. In this report, we have cloned and characterized the rag 2 gene of yellow catfish, and a particular pattern of expression was analysed in the major tissues of yellow catfish. Read More

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http://dx.doi.org/10.1016/j.dci.2019.04.006DOI Listing

Charcot-Leyden Crystal Concentration in Nasal Secretions Predicts Clinical Response to Glucocorticoids in Chronic Rhinosinusitis with Nasal Polyps.

J Allergy Clin Immunol 2019 Apr 16. Epub 2019 Apr 16.

Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing 100730, China. Electronic address:

Charcot-Leyden Crystal concentration in nasal secretions may serve as a suitable non-invasive biomarker with predictive capability for response to GC therapy in CRSwNP patients, and possibly lead to better strategies for GC therapy in future. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.03.029DOI Listing
April 2019
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What Are the Characteristics of the Upper Airway in Patients With Craniofacial Microsomia?

J Oral Maxillofac Surg 2019 Mar 26. Epub 2019 Mar 26.

Associate Professor, Dutch Craniofacial Center, Department of Oral and Maxillofacial Surgery, Erasmus University Hospital, Sophia Children's Hospital Rotterdam, Rotterdam, The Netherlands; Craniofacial Unit, Great Ormond Street Hospital, London, UK; Craniofacial Center, Department of Plastic and Oral Surgery, Boston Children's Hospital, Boston, MA.

Purpose: Obstructive sleep apnea (OSA) is a common problem in patients with craniofacial microsomia (CFM); however, the exact pathophysiology in patients with CFM remains unclear. The first aim of this study was to evaluate upper airway volume and morphology in patients with CFM. The second aim was to identify risk factors for the presence of OSA. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02782391193034
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http://dx.doi.org/10.1016/j.joms.2019.03.017DOI Listing
March 2019
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Markerless motion tracking and correction for PET, MRI, and simultaneous PET/MRI.

PLoS One 2019 19;14(4):e0215524. Epub 2019 Apr 19.

Department of Applied Mathematics and Computer Science, Technical University of Denmark, Lyngby, Denmark.

Objective: We demonstrate and evaluate the first markerless motion tracker compatible with PET, MRI, and simultaneous PET/MRI systems for motion correction (MC) of brain imaging.

Methods: PET and MRI compatibility is achieved by careful positioning of in-bore vision extenders and by placing all electronic components out-of-bore. The motion tracker is demonstrated in a clinical setup during a pediatric PET/MRI study including 94 pediatric patient scans. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215524PLOS
April 2019
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Bioactive sphingolipid profile in a xenograft mouse model of head and neck squamous cell carcinoma.

PLoS One 2019 19;14(4):e0215770. Epub 2019 Apr 19.

Departments of Medicine and Biochemistry & the Stony Brook Cancer Center at Stony Brook University, Stony Brook, New York, United States of America.

The purpose of this study was to determine the profile of bioactive sphingolipids in xenograft mouse tissues of head and neck squamous cell carcinoma. We utilized UHPLC-MS/MS to determine the profile of full set of ceramides, sphingosine, and sphingosine 1-phosphate in this xenograft mouse model. The tissues isolated and investigated were from brain, lung, heart, liver, spleen, kidney, bladder, tumors and blood. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215770PLOS

FDG PET based prediction of response in head and neck cancer treatment: Assessment of new quantitative imaging features.

PLoS One 2019 19;14(4):e0215465. Epub 2019 Apr 19.

Department of Radiation Oncology, The University of Iowa, Iowa City, United States of America.

Introduction: 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is now a standard diagnostic imaging test performed in patients with head and neck cancer for staging, re-staging, radiotherapy planning, and outcome assessment. Currently, quantitative analysis of FDG PET scans is limited to simple metrics like maximum standardized uptake value, metabolic tumor volume, or total lesion glycolysis, which have limited predictive value. The goal of this work was to assess the predictive potential of new (i. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215465PLOS

CancerInSilico: An R/Bioconductor package for combining mathematical and statistical modeling to simulate time course bulk and single cell gene expression data in cancer.

PLoS Comput Biol 2019 Apr 19;14(4):e1006935. Epub 2019 Apr 19.

Department of Oncology, Division of Biostatistics and Bioinformatics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD United States of America.

Bioinformatics techniques to analyze time course bulk and single cell omics data are advancing. The absence of a known ground truth of the dynamics of molecular changes challenges benchmarking their performance on real data. Realistic simulated time-course datasets are essential to assess the performance of time course bioinformatics algorithms. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006935DOI Listing

Natural Language Processing for Automated Quantification of Brain Metastases Reported in Free-Text Radiology Reports.

JCO Clin Cancer Inform 2019 Apr(3):1-9

1 Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Purpose: Although the bulk of patient-generated health data are increasing exponentially, their use is impeded because most data come in unstructured format, namely as free-text clinical reports. A variety of natural language processing (NLP) methods have emerged to automate the processing of free text ranging from statistical to deep learning-based models; however, the optimal approach for medical text analysis remains to be determined. The aim of this study was to provide a head-to-head comparison of novel NLP techniques and inform future studies about their utility for automated medical text analysis. Read More

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http://dx.doi.org/10.1200/CCI.18.00138DOI Listing

Evaluating crisaborole as a treatment option for atopic dermatitis.

Expert Opin Pharmacother 2019 Apr 19:1-7. Epub 2019 Apr 19.

d Department of Dermatology , Wake Forest School of Medicine , Winston-Salem , NC , USA.

Introduction: Atopic dermatitis (AD) is a chronic and recurrent disease presenting with eczematous lesions and pruritus. It impacts patient and family quality of life, increases morbidity, and accounts for large health-care expenditures. Although nonpharmacologic, topical, and systemic treatments exist, management of AD remains challenging due to limited treatment options. Read More

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http://dx.doi.org/10.1080/14656566.2019.1604688DOI Listing

Efficacy of three proton pump inhibitor therapeutic strategies on laryngopharyngeal reflux disease; a prospective randomized double blind study.

Clin Otolaryngol 2019 Apr 19. Epub 2019 Apr 19.

Department of Otorhinolaryngology-Head and Neck Surgery, Research Institute for Medical Sciences, Chungnam National University, School of Medicine, Daejeon, Republic of Korea.

Objectives: Proton pump inhibitor (PPI) prescribing practices in Laryngopharyngeal reflux disease (LPR) differ among physicians. We assessed the improvement in reflux symptom index (RSI) and reflux finding score (RFS) after treating LPR with three different regimens DESIGN: A prospective, double-blind, randomized clinical trial.

Setting: Chungnam national university hospital in Korea. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/coa.13345
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http://dx.doi.org/10.1111/coa.13345DOI Listing
April 2019
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Multiple interleaved mode saturation (MIMOSA) for B inhomogeneity mitigation in chemical exchange saturation transfer.

Magn Reson Med 2019 Apr 19. Epub 2019 Apr 19.

Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Germany.

Purpose: To mitigate inhomogeneity in quantitative CEST MRI at ultra-high magnetic field strengths (B ≥ 7 Tesla) using a parallel transmit system.

Methods: Multiple interleaved mode saturation employs interleaving of 2 complementary phase sets during the saturation pulse train. Phase differences of 45° (first mode) and 90° (second mode) between 2 adjacent transmitter coil channels are used. Read More

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http://dx.doi.org/10.1002/mrm.27762DOI Listing

A multicenter validation study for the EU-TIRADS using histological diagnosis as a gold standard.

Clin Endocrinol (Oxf) 2019 Apr 19. Epub 2019 Apr 19.

Thyroid Imaging and Cytopathology Centre, Paris, France.

Objective: Many systems for risk stratification of thyroid nodule with ultrasound (US) have been proposed and the EU-TIRADS issued by the ETA in 2017 was the last to have been published. The present study was undertaken to evaluate if the malignancy risk of each category corresponded to the given range of the guidelines and assess the diagnostic value of EU-TIRADS in a multi-institutional trial with histology as gold standard.

Design: Three institutions in Switzerland, France, and United Kingdom shared this retrospective study. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cen.13997
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http://dx.doi.org/10.1111/cen.13997DOI Listing
April 2019
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