24,714 results match your criteria Hawaii medical journal[Journal]


Pleomorphic and atypical multinucleated giant cells in solid pseudopapillary neoplasm of pancreas: A diagnostic pitfall in cytology and a review of the literature.

Diagn Cytopathol 2018 Dec 14. Epub 2018 Dec 14.

Department of Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio.

Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low-grade malignancy typically occurring in young women. Occasionally, these neoplasms present with pleomorphic to atypical multinucleated giant tumor cells which may mimic high-grade malignancy. Our patient is a 25-year-old male who presented with one year of intermittent epigastric pain. Read More

View Article
December 2018

Entecavir and peginterferon alfa-2a in adults with HBeAg-positive immune tolerant chronic hepatitis B virus infection.

Hepatology 2018 Dec 14. Epub 2018 Dec 14.

University of Michigan.

Background/aim: Monotherapy with interferon or nucleoside analog is generally not recommended during the immune tolerant (IT) phase of chronic hepatitis B virus (HBV) infection. Recognition that high HBV DNA levels are associated with hepatocellular carcinoma has increased interest in treating HBV in the IT phase. Small pediatric studies reported efficacy with combination nucleoside analog and interferon therapy. Read More

View Article
December 2018

Increased AURKA promotes cell proliferation and predicts poor prognosis in bladder cancer.

BMC Syst Biol 2018 Dec 14;12(Suppl 7):118. Epub 2018 Dec 14.

National Medical Centre of Colorectal Disease, The Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210001, China.

Background: Bladder cancer (BC) is the most common cancer of the urinary bladder and upper tract, in which the clinical management is limited. AURKA (aurora kinase A) has been identified as an oncogene in cancer development; however, its potential role and underlying mechanisms in the progression of BC remain unknown.

Results: In this study, we evaluated Aurora kinase A (AURKA) expression in patient samples by performing gene expression profiling, and found that AURKA expression levels were significantly higher in BC tissues than in normal tissues. Read More

View Article
December 2018
1 Read

The emerging role of microRNA-4487/6845-3p in Alzheimer's disease pathologies is induced by Aβ25-35 triggered in SH-SY5Y cell.

BMC Syst Biol 2018 Dec 14;12(Suppl 7):119. Epub 2018 Dec 14.

Department of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.

Background: Accumulation of amyloid β-peptide (Aβ) is implicated in the pathogenesis and development of Alzheimer's disease (AD). Neuron-enriched miRNA was aberrantly regulated and may be associated with the pathogenesis of AD. However, regarding whether miRNA is involved in the accumulation of Aβ in AD, the underlying molecule mechanism remains unclear. Read More

View Article
December 2018

Machine learning selected smoking-associated DNA methylation signatures that predict HIV prognosis and mortality.

Clin Epigenetics 2018 Dec 13;10(1):155. Epub 2018 Dec 13.

Department of Psychiatry, Yale School of Medicine, 300 George Street, 950 Campbell Ave, West Haven, New Haven, CT, 06511, USA.

Background: The effects of tobacco smoking on epigenome-wide methylation signatures in white blood cells (WBCs) collected from persons living with HIV may have important implications for their immune-related outcomes, including frailty and mortality. The application of a machine learning approach to the analysis of CpG methylation in the epigenome enables the selection of phenotypically relevant features from high-dimensional data. Using this approach, we now report that a set of smoking-associated DNA-methylated CpGs predicts HIV prognosis and mortality in an HIV-positive veteran population. Read More

View Article
December 2018
2 Reads

The Use of Mobile Health to Assist Self-management and Access to Services in a Rural Community.

Comput Inform Nurs 2018 Dec 12. Epub 2018 Dec 12.

Author Affiliations: School of Nursing, University of Nevada, Las Vegas (Dr Serafica); John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu (Dr Inouye); School of Nursing, Johns Hopkins University, Baltimore, MD (Dr Lukkahatai); School of Nursing & Dental Hygiene, University of Hawaii at Manoa, Honolulu, (Dr Braginsky); and Department of Kinesiology and Exercise Science (Dr Pacheco) and School of Nursing (Dr Daub), University of Hawaii at Hilo.

The purpose of this study was to explore the barriers to and needs for using mobile health technology to assist low-income Asian American and Pacific Islander participants living in rural Hawaii in their healthcare. Three focus groups consisting of patients, family support/significant others, and providers (N = 19) were conducted to assess the unique needs of low-income Asian American and Pacific Islander patients in rural Hawaii. The electronic health literacy scale was also used among participants in the patients and family support/significant other groups. Read More

View Article
December 2018

Randomized controlled trial evaluating the utility of urine HPV DNA for cervical cancer screening in a Pacific Island population.

J Glob Health Rep 2018 6;2. Epub 2018 Jul 6.

John A. Burns School of Medicine, Honolulu, Hawaii, USA.

Background: Non-invasive, self-collection sampling methods for human papillomavirus (HPV) DNA detection have the potential to address logistical and cultural barriers to Pap screening, particularly in under resourced settings such as Yap state in the Federated States of Micronesia - a population with low levels of screening and high incidence of cervical cancer.

Methods: A randomized controlled trial was conducted among adult women in Yap to compare cervical HPV DNA in self-collected urine and clinician-collected liquid cytology. Adult women aged 21-65 (n=217) were randomized by the order of sample collection. Read More

View Article

Natural Killer-derived exosomal miR-186 inhibits neuroblastoma growth and immune escape mechanisms.

Cancer Res 2018 Dec 12. Epub 2018 Dec 12.

University of Hawaii Cancer Center, University of Hawaii at Manoa

In neuroblastoma, the interplay between immune cells of the tumor microenvironment and cancer cells contributes to immune escape mechanisms and drug resistance. In this study, we show that NK cell-derived exosomes carrying the tumor suppressor microRNA (miR)-186 exhibit cytotoxicity against MYCN-amplified neuroblastoma cell lines. The cytotoxic potential of these exosomes was partly dependent upon expression of miR-186. Read More

View Article
December 2018

Associations of Adolescent Exposure to Severe Violence with Substance Use From Adolescence into Adulthood: Direct Versus Indirect Exposures.

Subst Use Misuse 2018 Dec 13:1-12. Epub 2018 Dec 13.

b Department of Population Health, NYU School of Medicine , New York , New York , USA.

Background: While previous research has documented the impact of violence on substance use, none has looked longitudinally across the lifespan to measure independent effects of direct and indirect violence exposure.

Objective: To examine independent associations between adolescent experiences of violence and subsequent substance use in adolescence and adulthood in the United States.

Method: Using the National Longitudinal Study of Adolescent to Adult Health (N = 12,288), we examined being shot or stabbed ("experienced"), being threatened with a knife or gun ("threatened"), and seeing someone either shot or stabbed ("witnessed") during adolescence (Wave I) as correlates of substance use in adolescence and adulthood (Wave IV) via logistic regression. Read More

View Article
December 2018

A First-in-Human Evaluation of a Novel Mesh-Covered Stent for Treatment of Carotid Stenosis in Patients at High Risk for Endarterectomy: 30-Day Results of the SCAFFOLD Trial.

JACC Cardiovasc Interv 2018 Dec;11(23):2396-2404

Lankenau Heart Institute, Main Line Health, Wynnewood, Pennsylvania.

Objectives: The primary purpose of this study was the composite of major adverse events through 30 days post-index procedure or ipsilateral stroke from 30 days to 1 year (365 days). Presented here is the composite of death, stroke, and myocardial infarction (MI) through 30 days.

Background: Rates of minor stroke have been higher with carotid artery stenting (CAS) compared with carotid endarterectomy (CEA). Read More

View Article
December 2018

Digital acoustic sensor performance across the infrasound range in non-isolated conditions.

J Acoust Soc Am 2018 Nov;144(5):3036

Infrasound Laboratory, University of Hawai'i at Manoa, 73970 Makako Bay Drive 205, Kailua-Kona, Hawaii 96740, USA.

The next generation of acoustic sensors is emerging to supplement legacy sensors traditionally used in regional and global networks. These devices operate under similar principles as traditional sensors, without the need of a separate external digitizer. The calibration of these sensors against their predecessors is crucial to the modernization of conventional technologies. Read More

View Article
November 2018

Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial.

Am J Clin Nutr 2018 Dec;108(6):1249-1258

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, School of Medicine, Vanderbilt University, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.

Background: Previous in vitro and in vivo studies indicate that enzymes that synthesize and metabolize vitamin D are magnesium dependent. Recent observational studies found that magnesium intake significantly interacted with vitamin D in relation to vitamin D status and risk of mortality. According to NHANES, 79% of US adults do not meet their Recommended Dietary Allowance of magnesium. Read More

View Article
December 2018
1 Read

Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer.

Authors:
Naomi Walsh Han Zhang Paula L Hyland Qi Yang Evelina Mocci Mingfeng Zhang Erica J Childs Irene Collins Zhaoming Wang Alan A Arslan Laura Beane-Freeman Paige M Bracci Paul Brennan Federico Canzian Eric J Duell Steven Gallinger Graham G Giles Michael Goggins Gary E Goodman Phyllis J Goodman Rayjean J Hung Charles Kooperberg Robert C Kurtz Núria Malats Loic LeMarchand Rachel E Neale Sara H Olson Ghislaine Scelo Xiao O Shu Stephen K Van Den Eeden Kala Visvanathan Emily White Wei Zheng Demetrius Albanes Gabriella Andreotti Ana Babic William R Bamlet Sonja I Berndt Ayelet Borgida Marie-Christine Boutron-Ruault Lauren Brais Paul Brennan Bas Bueno-de-Mesquita Julie Buring Kari G Chaffee Stephen Chanock Sean Cleary Michelle Cotterchio Lenka Foretova Charles Fuchs J Michael M Gaziano Edward Giovannucci Michael Goggins Thilo Hackert Christopher Haiman Patricia Hartge Manal Hasan Kathy J Helzlsouer Joseph Herman Ivana Holcatova Elizabeth A Holly Robert Hoover Rayjean J Hung Vladimir Janout Eric A Klein Robert C Kurtz Daniel Laheru I-Min Lee Lingeng Lu Núria Malats Satu Mannisto Roger L Milne Ann L Oberg Irene Orlow Alpa V Patel Ulrike Peters Miquel Porta Francisco X Real Nathaniel Rothman Howard D Sesso Gianluca Severi Debra Silverman Oliver Strobel Malin Sund Mark D Thornquist Geoffrey S Tobias Jean Wactawski-Wende Nick Wareham Elisabete Weiderpass Nicolas Wentzensen William Wheeler Herbert Yu Anne Zeleniuch-Jacquotte Peter Kraft Donghui Li Eric J Jacobs Gloria M Petersen Brian M Wolpin Harvey A Risch Laufey T Amundadottir Kai Yu Alison P Klein Rachael Z Stolzenberg-Solomon

J Natl Cancer Inst 2018 Dec 12. Epub 2018 Dec 12.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.

Background: Genome-wide association studies (GWAS) identify associations of individual single-nucleotide polymorphisms (SNPs) with cancer risk but usually only explain a fraction of the inherited variability. Pathway analysis of genetic variants is a powerful tool to identify networks of susceptibility genes.

Methods: We conducted a large agnostic pathway-based meta-analysis of GWAS data using the summary-based adaptive rank truncated product method to identify gene sets and pathways associated with pancreatic ductal adenocarcinoma (PDAC) in 9040 cases and 12 496 controls. Read More

View Article
December 2018
1 Read
12.583 Impact Factor

The antiviral mechanism of viperin and its splice variant in spring viremia of carp virus infected fathead minnow cells.

Fish Shellfish Immunol 2018 Dec 9. Epub 2018 Dec 9.

College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, China; Freshwater Aquaculture Collaborative Innovation Center of Hubei Province, Wuhan, 430070, China; Hubei Engineering Technology Research Center for Aquatic Animal Diseases Control and Prevention, Wuhan, 430070, China. Electronic address:

Viperin is known to play an important role in innate immune and its antiviral mechanisms are well demonstrated in mammals. Fish Viperin mediates antiviral activity against several viruses. However, little has been done to the underlying mechanism. Read More

View Article
December 2018
2 Reads

The 2018 rift eruption and summit collapse of Kīlauea Volcano.

Science 2018 Dec 11. Epub 2018 Dec 11.

U.S. Geological Survey, National Civil Applications Center, 12201 Sunrise Valley Dr., MS-562, Reston, VA 20192, USA.

In 2018, Kīlauea Volcano experienced its largest lower East Rift Zone (LERZ) eruption and caldera collapse in at least 200 years. After collapse of the Pu'u 'Ō'ō vent on 30 April, magma propagated downrift. Eruptive fissures opened in the LERZ on 3 May, eventually extending ~6. Read More

View Article
December 2018
1 Read

Comprehensive cancer control planning in the Pacific: the Cancer Council of the Pacific Islands a multi-national regional coalition.

Cancer Causes Control 2018 Dec 10. Epub 2018 Dec 10.

Cancer Council of the Pacific Islands, Yap State Department of Health Services, Yap State, Federated States of Micronesia, c/o Department of Family Medicine and Community Health, John A. Burns School of Medicine, University of Hawai'i, 651 Ilalo Street, MEB 224, Honolulu, HI, 96813, USA.

Introduction: In the early 1990s, a comprehensive cancer control (CCC) approach was developed in the United States (US). In 2003, the US-Affiliated Pacific Islands (USAPI) adopted the CCC approach through a regional coalition, the Cancer Council of the Pacific Islands (CCPI). Using the CCC approach, the CCPI developed jurisdiction-specific cancer coalitions and initiated their respective cancer plans. Read More

View Article
December 2018

Lilikoi: an R package for personalized pathway-based classification modeling using metabolomics data.

Gigascience 2018 Dec 1;7(12). Epub 2018 Dec 1.

Department of Computational Medicine and Bioinformatics, Building 520, 1600 Huron Parkway, Ann Arbor, MI 48109, USA.

Lilikoi (the Hawaiian word for passion fruit) is a new and comprehensive R package for personalized pathway-based classification modeling using metabolomics data. Four basic modules are presented as the backbone of the package: feature mapping module, which standardizes the metabolite names provided by users and maps them to pathways; dimension transformation module, which transforms the metabolomic profiles to personalized pathway-based profiles using pathway deregulation scores; feature selection module, which helps to select the significant pathway features related to the disease phenotypes; and classification and prediction module, which offers various machine learning classification algorithms. The package is freely available under the GPLv3 license through the github repository at: https://github. Read More

View Article
December 2018

Diffusiophoresis in ionic surfactants: effect of micelle formation.

Soft Matter 2018 Dec 11. Epub 2018 Dec 11.

Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, New Jersey 08544, USA.

We explore the consequences of micelle formation for diffusiophoresis of charged colloidal particles in ionic surfactant concentration gradients, using a quasi-chemical association model for surfactant self assembly. The electrophoretic contribution to diffusiophoresis is determined by re-arranging the Nernst-Planck equations, and the chemiphoretic contribution is estimated by making plausible approximations for the density profiles in the electrical double layer surrounding the particle. For sub-micellar solutions we find that a particle will typically be propelled down the concentration gradient, although electrophoresis and chemiphoresis are finely balanced and the effect is sensitive to the detailed parameter choices and simplifying assumptions in the model. Read More

View Article
December 2018

Preliminary observations of tool-processing behaviour in Hawaiian crows .

Commun Integr Biol 2018 21;11(4):e1509637. Epub 2018 Oct 21.

Centre for Biological Diversity, School of Biology, University of St Andrews, St Andrews, UK.

Very few animal species habitually make and use foraging tools. We recently discovered that the Hawaiian crow is a highly skilled, natural tool user. Most captive adults in our experiment spontaneously used sticks to access out-of-reach food from a range of extraction tasks, exhibiting a surprising degree of dexterity. Read More

View Article
October 2018
1 Read

The Weathervane.

Authors:
Russell T Stodd

Hawaii J Med Public Health 2018 Dec;77(12):338

View Article
December 2018

Insights in Public Health: Ke A'o Mau: Strengthening Cultural Competency in Interdisciplinary Education.

Hawaii J Med Public Health 2018 Dec;77(12):333-336

Myron B. Thompson School of Social Work, University of Hawai'i at Manoa, Honolulu, HI.

In order to successfully address social determinants of health and to achieve social justice for and all the people of Hawai'i, we must broaden our understanding of and approach to healing/health through interdisciplinary, culturally-informed education. Strengthening cultural competence within an Interprofessional Education framework, has potential in meeting important challenges in patient and population health, including meeting the increased demand for culturally trained professionals, increasing access to providers, and reducing health inequities in (Native Hawaiians). We present a model of course design and delivery, (Learning Preserved), intended to provide (students) with a unique body of culturally-anchored and community-based knowledge, skills and values that facilitate work with was implemented in the 2017-2018 academic year at University of Hawai'i (UH) at Manoa and optimized the authenticity of cultural learning through the engagement of (expert teachers) to instruct in their area of expertise. Read More

View Article
December 2018

Health Locus of Control Beliefs in Health Care Providers in the Pacific Basin.

Hawaii J Med Public Health 2018 Dec;77(12):325-329

Department of Obstetrics, Gynecology & Women's Health, John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI.

As part of the strategic plan to improve preconception care, health care providers are advised to counsel women about developing a reproductive life plan. Women are asked think about whether they want to become pregnant and have children and if so, when they would like to do so. The utility of a reproductive life plan is based on the premise that an individual has control over their own health and reproduction. Read More

View Article
December 2018

Inappropriate Laughter and Behaviours: How, What, and Why? Case of an Adult with Undiagnosed Gelastic Seizure with Hypothalamic Hamartoma.

Hawaii J Med Public Health 2018 Dec;77(12):319-324

John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI (NLB,JCK,AS).

Gelastic seizures (GS) are a rare form of epilepsy characterized by inappropriate, uncontrolled laughter. They are highly associated with abnormal cognitive development and behavioral problems in patients. Research has shown that GS can originate from hypothalamic hamartomas (HH), non- neoplastic masses consisting of gray matter with large and small neurons interspersed with glial nuclei. Read More

View Article
December 2018
1 Read

Dengue outbreaks in Hawai'i After WWII - A Review of Public Health Response and Scientific Literature.

Hawaii J Med Public Health 2018 Dec;77(12):315-318

Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawai'i at Manoa, Honolulu, HI (WYT, WKW).

The four serotypes of dengue virus (DENV) cause the most important and common arthropod-borne viral diseases in humans. There have been three major dengue outbreaks in Hawai'i since 1946. The most recent and largest outbreak occurred on Hawai'i Island in 2015-2016. Read More

View Article
December 2018

High Resource Utilization of Psychiatric Emergency Services by Methamphetamine Users.

Hawaii J Med Public Health 2018 Dec;77(12):312-314

Department of Psychiatry, John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI (BRS, BYL, JMO, TPT).

Methamphetamine use has increased throughout the United States in recent years, and is historically prevalent in Hawai'i. This retrospective study aimed to determine the effect of methamphetamine use on emergency department (ED) resources, by examining visits to an emergency department (ED) in an urban hospital in Hawai'i from 2007 - 2011. The rate of patients who tested positive for amphetamine was measured and broken down by year. Read More

View Article
December 2018

Relationships between Adipose Mitochondrial Function, Serum Adiponectin, and Insulin Resistance in Persons with HIV after 96 weeks of Antiretroviral Therapy.

J Acquir Immune Defic Syndr 2018 Nov 29. Epub 2018 Nov 29.

Johns Hopkins Univ., Baltimore, MD.

Objective: Some antiretroviral therapy (ART) and HIV itself confer metabolic risk, perhaps through altered mitochondrial function and adipokines. In ACTG study A5224s, adipose mitochondrial DNA (mtDNA) levels decreased on ART, and electron transport chain complex I (CI) and IV (CIV) activity decreased. Another study found decreased serum adiponectin on ART with mtDNA mutation m. Read More

View Article
November 2018

miR-192-5p silencing by genetic aberrations is a key event in hepatocellular carcinomas with cancer stem cell features.

Cancer Res 2018 Dec 7. Epub 2018 Dec 7.

Life Sciences Institute, Zhejiang University

Various cancer stem cell (CSC) biomarkers have been identified for hepatocellular carcinoma (HCC), but little is known about the implications of heterogeneity and shared molecular networks within the CSC population. Through miRNA profile analysis in a HCC cohort (n=241) for five groups of CSC+ HCC tissues, i.e. Read More

View Article
December 2018
9.329 Impact Factor

Borehole muography of subsurface reservoirs.

Philos Trans A Math Phys Eng Sci 2018 Dec 10;377(2137). Epub 2018 Dec 10.

Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.

Imaging subsurface rock formations or geological objects like oil and gas reservoirs, mineral deposits, cavities or even magmatic plumbing systems under active volcanoes has been for many years a major quest of geoscientists. Since these subsurface objects cannot be observed directly, different indirect methods have been developed. These methods are all based on variations of certain physical properties of the subsurface materials that can be detected from the ground surface or from boreholes. Read More

View Article
December 2018

Inhibition of dengue virus by curcuminoids.

Antiviral Res 2018 Dec 6. Epub 2018 Dec 6.

Department of Microbiology and Immunology, Georgetown University, Washington, D.C, USA. Electronic address:

The dengue virus is considered to be a globally important human pathogen prevalent in tropical and subtropical regions of the world. According to a recent estimate, the disease burden due to DENV infections is ∼390 million infections per year globally in ∼100 countries including the southern US, Puerto Rico and Hawaii, resulting in nearly ∼25,000 deaths mostly among children. Despite the significant morbidity and mortality that results from DENV infections, there is currently no effective chemotherapeutic treatment for DENV infections. Read More

View Article
December 2018
1 Read

Patient safety after implementation of a coproduced family centered communication programme: multicenter before and after intervention study.

BMJ 2018 Dec 5;363:k4764. Epub 2018 Dec 5.

Harvard Medical School, Boston, MA, USA.

Objective: To determine whether medical errors, family experience, and communication processes improved after implementation of an intervention to standardize the structure of healthcare provider-family communication on family centered rounds.

Design: Prospective, multicenter before and after intervention study.

Setting: Pediatric inpatient units in seven North American hospitals, 17 December 2014 to 3 January 2017. Read More

View Article
December 2018
2 Reads

Neighborhood social cohesion and cognitive function in U.S. Chinese older adults-findings from the PINE study.

Aging Ment Health 2018 Dec 6:1-9. Epub 2018 Dec 6.

d Institute for Health, Health Care Policy and Aging Research , Rutgers University, The State University of New Jersey , New Brunswick , New Jersey.

Objectives: The projected increase in the population of older adults in the United States entails a pressing need to examine risk and protective factors associated with cognitive function. This study aims to examine the association between neighborhood social cohesion and cognitive function among older Chinese adults in the United States.

Method: Using the first epidemiological survey of older Chinese Americans and applying ordinary least squares and quantile regressions, this study examines the association between neighborhood social cohesion and various domains of cognitive function. Read More

View Article
December 2018
1.781 Impact Factor

Update About the Effects of the Sunscreen Ingredients Oxybenzone and Octinoxate on Humans and the Environment.

Plast Surg Nurs 2018 Oct/Dec;38(4):158-161

Alfredo Siller, BS, is medical student, Medical College of Wisconsin, Milwaukee. Scott C. Blaszak, BS, is medical student, Medical College of Wisconsin, Milwaukee. Michelle Lazar, is college student, University of Wisconsin, Madison. Edit B. Olasz Harken, MD, PhD, is Associate Professor, Medical College of Wisconsin, Milwaukee. She is co-founder of Harken Derm LLC.

As skin cancer prevalence continues to rise, the importance of sun protection, including sunscreen use, has become accepted in the public. Sunscreens are divided into two main categories based on the type of their active ingredient, organic and inorganic ultraviolet (UV) filters. It has been shown that inorganic filters are more effective at blocking forms of UV light, both UVA and UVB, as compared with organic filters because organic sunscreens absorb and convert radiation whereas inorganic sunscreens reflect radiation. Read More

View Article
December 2018

Taking Care of Business-Lessons Learned Through Collaborative Process Mapping in Pacific and Atlantic Jurisdictions.

J Public Health Manag Pract 2019 Jan/Feb;25(1):92-94

Association of State and Territorial Health Officials, Arlington, Virginia (Mr Ensign and Ms Silva); and Pacific Island Health Officers Association, Honolulu, Hawaii (Ms Chutaro and Dr Durand).

View Article
December 2018

Descriptions of four new species of and new country records highlight the high biodiversity of fruit flies in Vietnam (Diptera, Tephritidae, Dacinae).

Zookeys 2018 19(797):87-115. Epub 2018 Nov 19.

University of Hawaii, Department of Plant and Environmental Protection Services, 3050 Maile Way, Honolulu, Hawaii, 96822-2231, USA.

Recent snap-shot surveys for fruit flies in Vietnam in 2015 and 2017 using traps baited with the male Dacinae fruit fly lures methyl eugenol, cue-lure and zingerone, collected 56 species, including 11 new country records and another 11 undescribed species, four of which are described in this paper. This increases the number of described species known to occur in Vietnam from 78 to 93. Species accumulation curves, based on the Chao 2 mean estimate, suggest that we collected 60-85 % of the local fauna at the sites sampled, and that species diversity decreases with increasing latitude. Read More

View Article
November 2018

Should Pass/Fail Grading Be Used Instead of Traditional Letter Grades in Dental Education? Two Viewpoints: Viewpoint 1: Pass/Fail Grading Improves Learning Experiences for Students and Viewpoint 2: Traditional Letter Grading Provides Objective Evaluation for Dental Education.

J Dent Educ 2018 Dec;82(12):1258-1264

Bruno C. Jham is Associate Professor and Associate Dean for Academic Affairs, College of Dental Medicine-Illinois, Midwestern University; Dolores Cannella is Associate Professor and Associate Dean for Education, School of Dental Medicine, Stony Brook University; Shawn Adibi is Associate Professor, Department of General Practice and Dental Public Health, The University of Texas School of Dentistry at Houston; Kim Austin is Associate Professor and Assistant Dean of Diversity, Inclusion, and Access, Herman Ostrow School of Dentistry of USC; Veeratrishul Allareddy is Professor, Department of Oral Pathology, Radiology, and Medicine, The University of Iowa College of Dentistry & Dental Clinics; and Cynthia S. Petrie is Associate Professor, Dr. George Tanaka Hawaii Professor of Restorative Dentistry, and Chair of the Department of Restorative Clinical Sciences, School of Dentistry, University of Missouri-Kansas City.

Discussions about which grading system (letter grade or pass/fail) is more effective in dental education have been occurring for several decades. As more institutions continue to consider the change from the traditional five-tier letter grading system (A/B/C/D/F) to a two-tier grading system (pass/fail), this debate will likely continue. This point/counterpoint article examines arguments for and against each type of grading system, taking into consideration academic performance, learning outcomes, psychological well-being, learning environment, acceptance/performance in postgraduate educational programs, and student motivation. Read More

View Article
December 2018

The high and heterogeneous burden of breast cancer in Hawaii: A unique multiethnic U.S. Population.

Cancer Epidemiol 2018 Nov 29;58:71-76. Epub 2018 Nov 29.

University of Hawaii Cancer Center, Cancer Epidemiology Program, 701 Ilalo Street, Honolulu, HI 96813, USA.

Background: While breast cancer incidence and mortality rates differ across racial/ethnic populations in the U.S., little is known about Asian and Pacific Island subpopulations. Read More

View Article
November 2018

Inhibition of microRNA-124-3p as a novel therapeutic strategy for the treatment of Gulf War Illness: Evaluation in a rat model.

Neurotoxicology 2018 Nov 29;71:16-30. Epub 2018 Nov 29.

Department of Clinical Investigation, Tripler Army Medical Center, 1 Jarrett White Road, Honolulu, Hawaii, 96859, USA. Electronic address:

Gulf War Illness (GWI) is a chronic, multisymptom illness that continues to affect up to 30% of veterans deployed to the Persian Gulf during the 1990-1991 Gulf War. After nearly 30 years, useful treatments for GWI are lacking and underlying cellular and molecular mechanisms involved in its pathobiology remain poorly understood, although exposures to pyridostigmine bromide (PB) and pesticides are consistently identified to be among the strongest risk factors. Alleviation of the broad range of symptoms manifested in GWI, which involve the central nervous system, the neuroendocrine system, and the immune system likely requires therapies that are able to activate and inactivate a large set of orchestrated genes. Read More

View Article
November 2018
2 Reads

Scenarios and Models to Support Global Conservation Targets.

Trends Ecol Evol 2018 Dec 1. Epub 2018 Dec 1.

CSIRO Land and Water, Canberra, ACT, Australia.

Global biodiversity targets have far-reaching implications for nature conservation worldwide. Scenarios and models hold unfulfilled promise for ensuring such targets are well founded and implemented; here, we review how they can and should inform the Aichi Targets of the Strategic Plan for Biodiversity and their reformulation. They offer two clear benefits: providing a scientific basis for the wording and quantitative elements of targets; and identifying synergies and trade-offs by accounting for interactions between targets and the actions needed to achieve them. Read More

View Article
December 2018
1 Read

The Dietary Inflammatory Index and All-Cause, Cardiovascular Disease, and Cancer Mortality in the Multiethnic Cohort Study.

Nutrients 2018 Dec 1;10(12). Epub 2018 Dec 1.

Cancer Center, University of Hawaii, Honolulu, HI 96813, USA.

Diet quality based on inflammatory potential, assessed by the Dietary Inflammatory Index (DII), has been related to mortality, but studies from racially/ethnically diverse populations are scarce. Using data from the Multiethnic Cohort Study in Hawaii and California, we investigated the association of the DII with all-cause, cardiovascular disease (CVD) and cancer mortality, both overall and by race/ethnicity. The analysis included 150,405 African Americans, Native Hawaiians, Japanese Americans, Latinos, and Whites aged 45⁻75 years, with 47,436 deaths during an average follow-up of 18. Read More

View Article
December 2018

Correlates of Mild Cognitive Impairment of Community-Dwelling Older Adults in Wuhan, China.

Int J Environ Res Public Health 2018 Nov 30;15(12). Epub 2018 Nov 30.

School of Health Sciences, Wuhan University, 115# Donghu Road, Wuhan 430071, China.

Mild cognitive impairment (MCI) is an early stage of Alzheimer's disease or other forms of dementia that occurs mainly in older adults. The MCI phase could be considered as an observational period for the secondary prevention of dementia. This study aims to assess potential differences in the risk of MCI among different elderly groups in Wuhan, China, and to further identify the most vulnerable populations using logistic regression models. Read More

View Article
November 2018
1 Read

An interprofessional team simulation exercise about a complex geriatric patient.

Gerontol Geriatr Educ 2018 Dec 4:1-14. Epub 2018 Dec 4.

a The John A. Hartford Foundation Center of Excellence in Geriatrics, Department of Geriatric Medicine, John A. Burns School of Medicine , University of Hawaii at Manoa , Honolulu , HI , USA.

Interprofessional collaboration is an essential skill to optimize the care of older adults with complex problems. We successfully developed and evaluated an interprofessional teamwork simulation exercise for medical, nursing, pharmacy, and social work students. Pharmacy students participated via video conferencing. Read More

View Article
December 2018
1 Read

Montelukast and Nasal Corticosteroids to Treat Pediatric Obstructive Sleep Apnea: A Systematic Review and Meta-analysis.

Otolaryngol Head Neck Surg 2018 Dec 4:194599818815683. Epub 2018 Dec 4.

1 Otolaryngology Head and Neck Surgery, Tripler Army Medical Center, Hawaii, USA.

Objective: To systematically review the literature on anti-inflammatory medications for treating pediatric obstructive sleep apnea and perform meta-analysis of the available data.

Data Sources: PubMed/MEDLINE and 4 additional databases.

Review Methods: Three authors independently and systematically searched through June 28, 2018, for studies that assessed anti-inflammatory therapy for treatment of pediatric obstructive sleep apnea (OSA). Read More

View Article
December 2018

Predictors of Participation in Invasive Species Control Activities Depend on Prior Experience with the Species.

Environ Manage 2018 Dec 3. Epub 2018 Dec 3.

Department of Wildland Resources, Utah State University, Logan, UT, USA.

The increasing worldwide spread of non-native species is both a component and a consequence of environmental change, and islands are especially vulnerable to negative effects. Efforts to control non-native species often include public education intended to promote behaviors designed to reduce or reverse their spread. To inform the use of information strategies to control the invasive, non-native frog Eleutherodactylus coqui in Hawaii, USA, we surveyed over 700 property owners about their attitudes and behaviors regarding the species. Read More

View Article
December 2018

Description of a new deep-water dogfish shark from Hawaii, with comments on the species complex in the West Pacific.

Zookeys 2018 21(798):135-157. Epub 2018 Nov 21.

Florida State University Coastal and Marine Laboratory, 3618 Coastal Highway, St. Teresa, FL 32358, USA Florida State University St. Teresa United States of America.

Dogfish sharks of the genus are small, deep-water sharks with a slow rate of molecular evolution that has led to their designation as a series of species complexes, with low between-species diversity relative to other taxa. The largest of these complexes is named for the Shortspine spurdog ( Jordan & Snyder), a medium-sized dogfish shark common to warm upper slope and seamount habitats, with a putative circumglobal distribution that has come under investigation recently due to geographic variation in morphology and genetic diversity. The Hawaiian population of was examined using both morphological and molecular analyses, putting this group in an evolutionary context with animals from the type population in Japan and closely-related congeners. Read More

View Article
November 2018