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    The efficacy of steroids for postoperative persistent inflammatory reaction in a patient with barium peritonitis: A case report.
    Int J Surg Case Rep 2017 May 15;36:38-41. Epub 2017 May 15.
    Department of Surgery and Science, Graduate School of Medicine and Pharmaceutical, Sciences for Research, University of Toyama, 2630 Sugitani, Toyama City, Toyama 930-0194, Japan, Japan. Electronic address:
    Introduction: Barium peritonitis is a serious and life-threatening disease requiring intensive care. Residual barium in the intraperitoneal cavity can cause persistent inflammation, postoperatively.

    Presentation Of Case: An 80-year-old woman was admitted to our hospital because of abdominal pain and vomiting after barium meal examination. Read More

    Association of cord blood chemokines and other biomarkers with neonatal complications following intrauterine inflammation.
    PLoS One 2017 22;12(5):e0175082. Epub 2017 May 22.
    Department of Pediatrics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan.
    Background: Intrauterine inflammation has been associated with preterm birth and neonatal complications. Few reports have comprehensively investigated multiple cytokine profiles in cord blood and precisely identified surrogate markers for intrauterine inflammation.

    Aim: To identify the cytokines and surrogate markers associated with intrauterine inflammation and subsequent neonatal complications. Read More

    The microbiome and hepatobiliary-pancreatic cancers.
    Cancer Lett 2017 May 17. Epub 2017 May 17.
    Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan. Electronic address:
    The human intestinal microbiome encompasses at least 100 trillion microorganisms that can influence host immunity and disease conditions, including cancer. Hepatobiliary and pancreatic cancers have been associated with poor prognosis owing to their high level of tumor invasiveness, distant metastasis, and resistance to conventional treatment options, such as chemotherapy. Accumulating evidence from animal models suggests that specific microbes and microbial dysbiosis can potentiate hepatobiliary-pancreatic tumor development by damaging DNA, activating oncogenic signaling pathways, and producing tumor-promoting metabolites. Read More

    Association of vitamin D insufficiency/deficiency with thyroid artery Doppler ultrasonography in patients with Hashimoto thyroiditis.
    Pak J Med Sci 2017 Mar-Apr;33(2):295-299
    Prof. Dr. Hakan Cinemre, Departments of Internal Medicine, Sakarya University School of Medicine, Sakarya, Turkey.
    Background & Objective: During the course of the autoimmune thyroid diseases, ultrasonography change parallel to histopathology. Vitamin D is associated with autoimmune diseases and thus can affect thyroid blood flow. Our aim was to investigate the relationship between vitamin D insufficiency/deficiency and thyroid hemodynamic indices in patients with Hashimoto thyroiditis. Read More

    Coexistence of ulcerative colitis and Sjögren's syndrome in a patient with Takayasu's arteritis and Hashimoto's thyroiditis.
    Intest Res 2017 Apr 27;15(2):255-259. Epub 2017 Apr 27.
    Department of Pathology, Kyungpook National University School of Medicine, Daegu, Korea.
    A 31-year-old woman with a 15-year history of Takayasu's arteritis (TA) and a 13-year history of Hashimoto's thyroiditis presented with hematochezia. She received a diagnosis of Sjögren's syndrome at 1 month before her visit to Kyungpook National University Medical Center. Her colonoscopic findings were compatible with a diagnosis of ulcerative colitis (UC). Read More

    Identification of chronic kidney disease patient characteristics influencing the renoprotective effects of febuxostat therapy: a retrospective follow-up study.
    BMC Nephrol 2017 May 18;18(1):162. Epub 2017 May 18.
    Department of Nephrology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.
    Background: The ability of antihyperuricemic therapy to exert renoprotective effects in patients with chronic kidney disease (CKD) is controversial. In the present study, we studied patient characteristics that may mask favorable impact of antihyperuricemic therapy on the progression of CKD.

    Methods: This was a single-center, retrospective, follow-up study. Read More

    Growth Hormone Treatment and Adverse Events.
    Pediatr Endocrinol Rev 2017 Mar;14(Suppl 1):235-239
    Tanaka Growth Clinic, Tokyo, Japan.
    We compiled the major adverse events included in the Annual Research Reports of the Foundation for Growth Research published in and after 2000. We conducted a review of approximately 32,000 patients treated with growth hormone (GH) who subsequently developed leukemia and who were registered with the Foundation for Growth Research (from 1975 to December 31 1997). We performed a literature review and found that GH therapy was not associated with leukemia onset in patients with no risk factors for leukemia. Read More

    Secondary Sjogren's Syndrome Presenting with Distal Tubular Acidosis and Quadriparesis.
    Indian J Crit Care Med 2017 Apr;21(4):243-244
    Department of Critical Care Medicine, Yashoda Multi-speciality Hospital, Hyderabad, Telangana, India.
    A 52-year-old female patient was admitted to Intensive Care Unit with complaints of quadriparesis. Investigations revealed distal renal tubular acidosis (DRTA) secondary to Sjogren's syndrome with involvement of the parotid and thyroid glands. Laboratory investigations showed hyperchloremic metabolic acidosis and an alkaline urine pH with clinical signs of sicca syndrome. Read More

    Successful Treatment of Primary Cutaneous Peripheral T-Cell Lymphoma Presenting Acquired Ichthyosis with Oral Bexarotene Monotherapy.
    Case Rep Oncol 2017 Jan-Apr;10(1):328-332. Epub 2017 Apr 6.
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
    Acquired ichthyosis (AI) is a reactive cutaneous manifestation that can be associated with malignant hematological disease, including cutaneous T-cell lymphoma (CTCL). Since it is difficult to distinguish AI from ichthyosiform mycosis fungoides, to select the treatment for CTCL with ichthyosis-like appearance and to evaluate its efficacy is sometimes challenging. In this report, we describe a case of primary cutaneous peripheral T-cell lymphoma not otherwise specified presenting AI successfully treated with oral bexarotene. Read More

    Fatty liver as a risk factor for progression from metabolically healthy to metabolically abnormal in non-overweight individuals.
    Endocrine 2017 May 16. Epub 2017 May 16.
    Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
    Purpose: Recent studies identified that metabolically abnormal non-obese phenotype is a risk factor for cardiovascular diseases. However, little is known about risk factor for progression from metabolically healthy non-overweight to metabolically abnormal phenotype. We hypothesized that fatty liver had a clinical impact on progression from metabolically healthy non-overweight to metabolically abnormal phenotype. Read More

    Prospective Observational Post-Marketing Study of Tafluprost for Glaucoma and Ocular Hypertension: Effectiveness and Treatment Persistence.
    Adv Ther 2017 May 13. Epub 2017 May 13.
    Santen Pharmaceutical Co., Ltd., Osaka, Japan.
    Introduction: The aim of this study was to investigate the long-term intraocular pressure (IOP)-lowering effect and safety of tafluprost, a prostaglandin analogue, in actual clinical practice and to determine persistency of tafluprost as an indicator of its benefit-risk balance.

    Methods: This was a large-scale, post-marketing, multicenter, non-interventional, open-label, long-term study. Patients with glaucoma or ocular hypertension who initiated tafluprost treatment were registered and prospectively observed over a 2-year period in the real-world setting in Japan. Read More

    Post-chemotherapy PD-L1 expression correlates with clinical outcomes in Japanese bladder cancer patients treated with total cystectomy.
    Med Oncol 2017 Jun 12;34(6):117. Epub 2017 May 12.
    Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifucho, Hirosaki, Aomori, 036-8562, Japan.
    Programmed cell death ligand-1 (PD-L1) is a key target molecule of immunotherapy that is frequently overexpressed in bladder cancer. In the present study, we examined whether PD-L1 expression is associated with clinical outcomes in bladder cancer patients. We enrolled 102 bladder cancer patients treated with cystectomy at the Aomori Prefectural Hospital between April 2004 and May 2014. Read More

    Evaluating the safety of β-interferons in MS: A series of nested case-control studies.
    Neurology 2017 May 12. Epub 2017 May 12.
    From the Division of Neurology and Centre for Brain Health (H.J.I.d.J., E.K., A.S., Y.Z., F.Z., M.L.v.d.K., A.T., H.T.), Department of Medicine, and Vancouver Coastal Health Research Institute, University of British Columbia, Canada; School for Mental Health and Neuroscience (H.J.I.d.J., J.W.C.T., R.H.), Maastricht University Medical Center, the Netherlands; College of Pharmacy and Nutrition (C.E.), University of Saskatchewan, Saskatoon, Canada; Department Public Health Sciences (M.L.v.d.K.), Karolinska Institutet, Stockholm, Sweden; Department of Statistics (P.G., J.P.), University of British Columbia, Vancouver, Canada; and Departments of Internal Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
    Objective: To examine the association between interferon-β (IFN-β) and potential adverse events using population-based health administrative data in British Columbia, Canada.

    Methods: Patients with relapsing-remitting multiple sclerosis (RRMS) who were registered at a British Columbia Multiple Sclerosis Clinic (1995-2004) were eligible for inclusion and were followed up until death, absence from British Columbia, exposure to a non-IFN-β disease-modifying drug, or December 31, 2008. Incidence rates were estimated for each potential adverse event (selected a priori and defined with ICD-9/10 diagnosis codes from physician and hospital claims). Read More

    Increased Risk of Chronic Spontaneous Urticaria in Patients With Autoimmune Thyroid Diseases: A Nationwide, Population-based Study.
    Allergy Asthma Immunol Res 2017 Jul;9(4):373-377
    Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
    There was no previous population-based study on the comparison of the risk of chronic spontaneous urticaria (CSU) between autoimmune thyroid diseases (AITD) and age- and gender-matched controls. The primary objective of this study was to evaluate the risk of CSU after diagnosis of AITD using national registry data from Korea. The secondary objective was to evaluate other risk factors of CSU. Read More

    Case of shift from linear immunoglobulin A bullous dermatosis to pemphigus herpetiformis for a short period of time.
    J Dermatol 2017 Feb 5;44(2):189-193. Epub 2016 Nov 5.
    Department of Dermatology, Kurume University School of Medicine, Kurume, Japan.
    Pemphigus herpetiformis (PH) is a rare variant of pemphigus characterized by erythemas and vesicles, tending to present with annular-shaped lesions. Immunologically, immunoglobulin (Ig)G deposition at the keratinocyte cell surfaces is observed. Linear IgA bullous dermatosis (LABD) is a rare subepidermal blistering disease with linear IgA deposits at the epidermal basement membrane zone (BMZ). Read More

    Prognostic Value of Preoperative Anti-thyroglobulin Antibody in Differentiated Thyroid Cancer.
    Clin Endocrinol (Oxf) 2017 May 10. Epub 2017 May 10.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
    Context: The coexistence of differentiated thyroid cancer (DTC) and thyroid autoimmune disease could represent a better or worse prognosis. This study investigated the prognostic importance of preoperative anti-thyroglobulin antibody (TgAb) in DTC patients.

    Design And Patients: This retrospective hospital-cohort study enrolled 1,171 consecutive DTC patients with preoperative TgAb data, who underwent total thyroidectomy between January 2006 and December 2011. Read More

    Multicystic biliary hamartoma with extremely elevated CA19-9: a case report.
    Scand J Gastroenterol 2017 May 9:1-4. Epub 2017 May 9.
    a Department of Gastroenterological Surgery, Graduate School of Life Sciences , Kumamoto University , Kumamoto , Japan.
    Multicystic biliary hamartoma (MCBH) is a rare cystic disease of the liver. We herein report a case of MCBH associated with extremely elevated levels of serum carbohydrate antigen (CA) 19-9. A 53-year-old man was referred to our hospital because of extremely elevated CA19-9 levels (more than 12,000 U/mL). Read More

    Steroid-Responsive Chronic Schizophreniform Syndrome in the Context of Mildly Increased Antithyroid Peroxidase Antibodies.
    Front Psychiatry 2017 21;8:64. Epub 2017 Apr 21.
    Faculty of Medicine, Department of Psychiatry, Section for Experimental Neuropsychiatry, University of Freiburg, Freiburg, Germany.
    Background: Schizophreniform syndromes can be divided into primary forms from polygenic causes or secondary forms due to immunological, epileptiform, monogenic, or degenerative causes. Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) is a secondary immunological form associated with increased thyroid antibodies, such as antithyroid peroxidase antibodies and shows a good response to corticosteroids.

    Case Presentation: We present the case of a 41-year-old woman suffering from a schizophreniform syndrome. Read More

    Two cases of perforated duodenal diverticulum successfully treated using conservative therapy.
    Nihon Shokakibyo Gakkai Zasshi 2017 ;114(5):871-880
    Department of Hepatology, Japanese Red Cross Okayama Hospital.
    We encountered two cases of perforated duodenal diverticulum successfully treated with conservative therapy. The first case involved a 72-year-old man who presented with abdominal pain and fever. An abdominal computed tomography revealed pneumoretroperitoneum. Read More

    An unusual cause of orthopnoea-hashimoto's thyroiditis presenting as bilateral diaphragmatic palsy.
    Respir Med Case Rep 2017 21;21:132-134. Epub 2017 Apr 21.
    Department of Medicine, Govt. Medical College, Kozhikode, Kerala, India.
    We report a case of 36 yr old male without any comorbidities, who presented with a history of gradually progressive dyspnoea and orthopnoea for 6 months. Physical examination revealed bradycardia, paradoxical respiration suggestive of bilateral diaphragmatic palsy. Fluoroscopy demonstrated the presence of bilateral diaphragmatic paralysis. Read More

    Psychiatric Presentations Heralding Hashimoto's Encephalopathy: A Systematic Review and Analysis of Cases Reported in Literature.
    J Neurosci Rural Pract 2017 Apr-Jun;8(2):261-267
    Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
    Hashimoto's encephalopathy (HE) may often present initially with psychiatric symptoms. These presentations are often variable in clinical aspects, and there has been no systematic analysis of the numerous psychiatric presentations heralding an eventual diagnosis of HE which will guide clinicians to make a correct diagnosis of HE. This systematic review was done to analyze the demographic characteristics, symptom typology, and clinical and treatment variables associated with such forerunner presentations. Read More

    Characteristics and timing of recurrence during postoperative surveillance after curative resection for lung adenocarcinoma.
    Surg Today 2017 May 4. Epub 2017 May 4.
    Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata, Niigata, 951-8510, Japan.
    Purpose: To establish the most effective methods of postoperative surveillance to detect early recurrence of lung adenocarcinoma.

    Methods: The subjects of this retrospective study were 485 patients with p-stage I-III lung adenocarcinoma, who underwent postoperative surveillance. We examined the sites and detection modes of recurrence and calculated the recurrence-free probabilities. Read More

    Clinical practice guidelines for the diagnosis and management of otitis media with effusion (OME) in children in Japan, 2015.
    Auris Nasus Larynx 2017 May 1. Epub 2017 May 1.
    Department of Health Informatics, Kyoto University School of Public Health, Japan.
    Objective: To (1) indicate the definition, the disease state, methods of diagnosis, and testing for otitis media with effusion (OME) in childhood (<12 years); and (2) recommend methods of treatment in accordance with the evidence-based consensus reached by the Subcommittee of Clinical Practice Guideline for Diagnosis and Management of OME in Children.

    Methods: We produced Clinical Questions (CQs) concerning the treatment of OME and searched the literature published until April 2014 according to each theme including CQ, the definition, the disease state, the method of diagnosis, and examination. The recommendations are based on the results of the literature review and the expert opinion of the Subcommittee. Read More

    Phenanthridin-6-one derivatives as the first class of non-steroidal pharmacological chaperones for Niemann-Pick disease type C1 protein.
    Bioorg Med Chem Lett 2017 Apr 22. Epub 2017 Apr 22.
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan; RIKEN, 2-1, Hirosawa, Wako-shi, Saitama 351-0198, Japan. Electronic address:
    Niemann-Pick disease type C is a fatal, progressive neurodegenerative disease mostly caused by mutations in Nieamnn-Pick type C1 (NPC1), a late endosomal membrane protein that is essential for intracellular cholesterol transport. The most prevalent mutation, I1061T (Ile to Thr), interferes with the protein folding process. Consequently, mutated but intrinsically functional NPC1 proteins are prematurely degraded via proteasome, leading to loss of NPC1 function. Read More

    BREG cells in Hashimoto's thyroiditis isolated or associated to further organ-specific autoimmune diseases.
    Clin Immunol 2017 Apr 28. Epub 2017 Apr 28.
    Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Latina, Italy; Endocrinology Unit, AUSL Latina, Latina, Italy. Electronic address:
    Hashimoto thyroiditis (HT) may occur isolated or associated with other non-endocrine autoimmune disorders (NEAD). No data are available about Breg cells in these disorders and this represented the aim of the study. Th17 and Breg cells subset were characterized on peripheral blood mononuclear cells isolated from 18 healthy donors (HD), 19 patients with isolated HT and 26 patients with HT+NEAD. Read More

    An unusual case of adult-onset multi-systemic Langerhans cell histiocytosis with perianal and incident thyroid involvement.
    Endocrinol Diabetes Metab Case Rep 2017 2;2017. Epub 2017 Feb 2.
    Department of Endocrinology and Metabolism.
    Summary: Langerhans cell histiocytosis (LCH) is a rare sporadic disease characterized by histiocytic neoplastic infiltration of various organ systems and a wide spectrum of clinical manifestations, ranging from benign and self-limiting to lethal. Herein, we report a rare case of adult-onset multi-systemic LCH in a 36-year-old male patient with an initial perianal presentation and incidental finding of subsequent thyroid gland involvement in the follow-up period. The patient with a history of perianal LCH treated with surgical excision and local radiotherapy was referred to our Endocrinology Department upon detection of hypermetabolic nodular lesions in the left lateral lobe of thyroid gland on positron emission tomography-computed tomography (PET/CT) scan in the nineth month of follow-up. Read More

    Z-score of Mitral Annular Plane Systolic Excursion is a Useful Indicator of Evaluation of Left Ventricular Function in Patients with Acute-Phase Kawasaki Disease.
    Pediatr Cardiol 2017 Apr 29. Epub 2017 Apr 29.
    Department of pediatrics, Kurobe City Hospital, Kurobe, Japan.
    We previously reported the clinical usefulness of the mitral annular plane systolic excursion (MAPSE) to evaluate the left ventricular (LV) function in patients with Kawasaki disease (KD) in the acute-phase. However, the feasibility of the MAPSE z-score has not been evaluated in patients with acute KD. We prospectively studied 60 KD patients without coronary aneurysms. Read More

    Thyroid disorders and mammographic density in Spanish women: Var-DDM study.
    Breast 2017 Apr 26;34:12-17. Epub 2017 Apr 26.
    Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), CIBERESP, Spain; Cancer Epidemiology Research Group, Oncology and Hematology Area, IIS Puerta de Hierro (IDIPHIM), Madrid, Spain. Electronic address:
    Objectives: The association between breast cancer (BC) and thyroid disorders has been widely explored with unclear results. Mammographic density (MD) is one of the strongest risk factor for BC. This study explores the relationship between thyroid diseases and MD in Spanish women. Read More

    Decrease in an anti-ageing factor, growth differentiation factor 11, in chronic obstructive pulmonary disease.
    Thorax 2017 Apr 28. Epub 2017 Apr 28.
    Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
    Rationale: Cellular senescence is observed in the lungs of patients with COPD and may contribute to the disease pathogenesis. Growth differentiation factor 11 (GDF11) belongs to the transforming growth factor β superfamily and was recently reported to be a circulating protein that may have rejuvenating effects in mice. We aimed to investigate the amounts of GDF11 in the plasma and the lungs of patients with COPD and elucidate the possible roles of GDF11 in cellular senescence. Read More

    Ionic Liquid-Mediated Hydrofluorination of o-Azaxylylenes Derived from 3-Bromooxindoles.
    Org Lett 2017 May 28;19(10):2572-2575. Epub 2017 Apr 28.
    Nishiisahaya Hospital , 3015 Kaizu, Isahaya, Nagasaki 854-0063, Japan.
    The hydrofluorination reaction of 3-bromooxindole using mild HF reagents in an ionic liquid is described. This transformation can operate at room temperature to give a series of 3-substituted 3-fluorooxindole derivatives including racemic BMS 204352 (MaxiPost). The mechanistic study about interactions between HF and 3-butyl-1-methylimidazolium tetrafluoroborate [bmim][BF4] is also discussed on the basis of energy calculations. Read More

    Predictors for recurrent/persistent high-grade intraepithelial lesions and cervical stenosis after therapeutic conization: a retrospective analysis of 522 cases.
    Int J Clin Oncol 2017 Apr 27. Epub 2017 Apr 27.
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
    Objective: The objective of the study is to identify the risk factors associated with recurrent/persistent disease and cervical stenosis after conization.

    Methods: Five hundred twenty-two (522) cases of high-grade intraepithelial lesions treated by conization were retrospectively reviewed. Risk factors associated with recurrent/persistent disease were analyzed by univariate and multivariate analysis using a Cox hazard regression model. Read More

    Thyroid Ultrasonography in Differentiation between Graves' Disease and Hashimoto's Thyroiditis.
    J Biomed Phys Eng 2017 Mar 1;7(1):21-26. Epub 2017 Mar 1.
    Medical Imaging Research Center, Department of Radiology, Shiraz University of Medical Sciences, Shiraz, Iran.
    Objective: Graves' disease and Hashimoto's thyroiditis are the most common causes of hyper and hypothyroidism, respectively. Differentiation of these 2 diseases, if the patient is euthyroid, may sometimes be extremely difficult on the basis of clinical and laboratory findings. The purpose of this study was to determine the sensitivity and specificity of gray scale sonography in differentiation of Graves' disease from Hashimoto's thyroiditis. Read More

    Successful treatment with denosumab in a patient with sacral giant cell tumor of bone refractory to combination therapy with arterial embolization and zoledronic acid: A case report.
    Mol Clin Oncol 2017 Mar 23;6(3):307-310. Epub 2017 Jan 23.
    Department of Orthopedic Surgery, Kindai University Faculty of Medicine, Osakasayama, Osaka 589-8511, Japan.
    Giant cell tumor of bone (GCTB) is commonly treated with surgery; however, surgery of GCTB in the sacrum may be challenging due to the associated risk. A conservative approach may be selective arterial embolization or zoledronic acid (ZOL) treatment; however, there are currently no studies investigating the efficacy of combining these two treatments. Denosumab may also be used; however, to the best of our knowledge, there are no reports of a stepwise approach for the use of all three treatments in a single patient. Read More


    Prevalence and clinical relevance of thyroid stimulating hormone receptor-blocking antibodies in autoimmune thyroid disease.
    Clin Exp Immunol 2017 Apr 25. Epub 2017 Apr 25.
    Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany.
    The prevalence and clinical relevance of thyroid stimulating hormone (TSH) receptor (TSHR) blocking antibodies (TBAb) in patients with autoimmune thyroid disease (AITD) was investigated. Serum TBAb were measured with a reporter gene bioassay using Chinese hamster ovary cells. Blocking activity was defined as percentage inhibition of luciferase expression relative to induction with bovine TSH alone (cut-off 40% inhibition). Read More

    The Emerging Role of Epigenetics in Autoimmune Thyroid Diseases.
    Front Immunol 2017 7;8:396. Epub 2017 Apr 7.
    Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.
    Autoimmune thyroid diseases (AITD) are a group of both B cell- and T cell-mediated organ-specific autoimmune diseases. Graves' disease and Hashimoto thyroiditis are the two main clinical presentations of AITD. Both genetic and environmental factors have important roles in the development of AITD. Read More

    Quantification and physiological significance of the rightward shift of the V-slope during incremental cardiopulmonary exercise testing.
    BMC Sports Sci Med Rehabil 2017 20;9. Epub 2017 Apr 20.
    Cardiology, Hokko Memorial Hospital, 1-6 Kita-27 Higashi-8, Higashiku, Sapporo, 065-0027 Japan.
    Background: Ventilatory anaerobic threshold (VAT) is frequently used as a measure of exercise tolerance, with the V-slope method being the standard; however, this needs to be visually determined. Over the years, we have observed that the V-slope itself often appears to shift rightward before the appearance of the VAT (RtShift: rightward shift of V-slope). This phenomenon has long been known to occur during the first 1-2 min of steady-state exercise and disappears thereafter; it is attributed to CO2 storage, presumably in active muscle. Read More

    Hashimoto encephalopathy with high plasma monoamine metabolite levels: a case report.
    Neuropsychiatr Dis Treat 2017 7;13:1043-1045. Epub 2017 Apr 7.
    Department of Neuropsychiatry, Fukushima Medical University School of Medicine.
    Hashimoto encephalopathy (HE) is believed to be an immune-mediated disorder associated with Hashimoto's thyroiditis. It was suggested that neuropsychiatric symptoms, the presence of antithyroid antibody, and good response to steroids were important for the diagnosis of HE. It has been reported that homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG), which are monoamine metabolites of dopamine and noradrenaline, respectively, are the possible biomarkers of neuropsychiatric diseases. Read More

    Protein oxidation and autoantibodies' reactivity against malondialdehyde and hydrogen peroxide-modified thyroid antigens in plasma of patients with Graves' disease and Hashimoto Thyroiditis.
    Chem Biol Interact 2017 Apr 18. Epub 2017 Apr 18.
    Laboratory LR11ES45, Research Group "Biotechnology and Pathology", National School of Engineers, Univeristy of Sfax, Tunisia; Service of Nuclear Medicine, CHU Habib Bourguiba, Sfax, Tunisia.
    The aim of this study was first to investigate the oxidative proteins modifications in the plasma of both autoimmune thyroid diseases (AITD), Graves' disease (GD) and Hashimoto Thyroiditis (HT). Then, the impact of these oxidative modifications on immune response was evaluated by measuring the reactivity of patients' autoantibodies against malondialdéhyde (MDA) and Hydrogen peroxide (H2O2) modified thyroid antigens (T.Ag) in comparison to native ones. Read More

    Hypothyroidism in Pediatric Population - Bosnian and Herzegovinian Situation.
    Med Arch 2017 Feb 5;71(1):62-65. Epub 2017 Feb 5.
    Faculty of Medicine, Sarajevo School of Science and Technology, Sarajevo, Bosnia and Herzegovina.
    Introduction: Thyroid gland diseases in children are in second place by frequency among all endocrine disorders. When interpreting the results of the thyroid function assessment it should be taken into account the significant differences in the concentrations of TSH, thyroid hormones, thyroid binding proteins and calcitonin among children of different ages.

    Goal: To present the age and sex structure of the patients diagnosed with hypothyroidism, evaluate diagnostic methods for making diagnosis, evaluation of etiology of hypothyroidism, with special review of the therapeutic modality. Read More

    Total thyroidectomy for pressure symptoms in patients with Hashimoto's thyroiditis.
    ANZ J Surg 2017 Apr 16. Epub 2017 Apr 16.
    Department of Surgery, The Alfred Hospital, Melbourne, Victoria, Australia.
    Background: Hashimoto's thyroiditis (HT) is rarely on its own the indication for thyroidectomy. However, surgery in patients with HT will be undertaken when there is malignancy and may be required for pressure symptoms. Therefore, this study aimed to investigate the indications for surgery in HT patients. Read More

    Circulating Tumor Cell Count Can Be a Useful Prognostic Factor in Lung Resection via Cardiopulmonary Bypass.
    Case Rep Oncol 2017 Jan-Apr;10(1):169-174. Epub 2017 Feb 15.
    Department of Thoracic Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
    Tumor resection with cardiopulmonary bypass (CPB) remains controversial in the field of oncology. Here, we present a 57-year-old male patient with locally advanced squamous cell carcinoma. The tumor was located in the left hilum and invaded the left atrium. Read More

    Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior.
    J Exp Med 2017 May 13;214(5):1431-1452. Epub 2017 Apr 13.
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
    Abnormal epigenetic regulation can cause the nervous system to develop abnormally. Here, we sought to understand the mechanism by which this occurs by investigating the protein complex cohesin, which is considered to regulate gene expression and, when defective, is associated with higher-level brain dysfunction and the developmental disorder Cornelia de Lange syndrome (CdLS). We generated conditional Smc3-knockout mice and observed greater dendritic complexity and larger numbers of immature synapses in the cerebral cortex of Smc3(+/-) mice. Read More

    Comorbidity of chronic spontaneous urticaria and autoimmune thyroid diseases: a systematic review.
    Allergy 2017 Apr 13. Epub 2017 Apr 13.
    Charité - Universitätsmedizin Berlin, Department of Dermatology and Allergy, Berlin, Germany.
    Chronic spontaneous urticaria (CSU) patients are widely held to often have other autoimmune disorders, including autoimmune thyroid disease. Here, we systematically evaluated the literature on the prevalence of thyroid autoimmunity in CSU and vice versa. There is a strong link between CSU and elevated levels of IgG anti-thyroid autoantibodies (AAbs), with most of a large number of studies reporting rates of ≥10%. Read More

    Effects of Vitamin D deficiency treatment on metabolic markers in Hashimoto thyroiditis patients.
    J Res Med Sci 2017 27;22. Epub 2017 Jan 27.
    Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: The aim of the current trial was to investigate the effect of Vitamin D treatment on metabolic markers in people with Vitamin D deficiency and thyroid autoimmunity.

    Materials And Methods: In this double-blind, randomized, placebo-controlled clinical trial, 65 Vitamin D deficient euthyroid or hypothyroid patients with positive TPO-Ab were enrolled. They randomly allocated into two groups to receive oral Vitamin D3 (50000 IU weekly) and placebo for 12 weeks. Read More

    Carbamylated albumin is one of the target antigens of anti-carbamylated protein antibodies.
    Rheumatology (Oxford) 2017 Apr 7. Epub 2017 Apr 7.
    Department of Rheumatology and Clinical Immunology.
    Objectives.: Anti-carbamylated protein (anti-CarP) antibodies are detected in RA patients. Fetal calf serum is used as an antigen source in anti-CarP ELISA, and the precise target antigens have not been found. Read More

    Paraneoplastic Pemphigus Associated with a Malignant Thymoma: A Case of Persistent and Refractory Oral Ulcerations Following Thymectomy.
    Ann Dermatol 2017 Apr 24;29(2):219-222. Epub 2017 Mar 24.
    Department of Dermatology, Gangnam Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
    Paraneoplastic pemphigus is a rare, life-threatening autoimmune mucocutaneous blistering disease associated with underlying neoplasia, commonly lymphoproliferative tumors. Herein we report a case of paraneoplastic pemphigus with a unique autoantibody profile associated with a malignant thymoma. A 56-year-old female patient presented with relapsing oral ulcerations accompanied by erythematous papules and patches on her extremities for 2 months. Read More

    Monthly oral ibandronate 100 mg is as effective as monthly intravenous ibandronate 1 mg in patients with various pathologies in the MOVEST study.
    J Bone Miner Metab 2017 Apr 7. Epub 2017 Apr 7.
    Aoba Hospital, Tokyo, Japan.
    The non-inferiority of oral ibandronate 100 mg to intravenous (i.v.) ibandronate 1 mg in increasing lumbar spine (LS) bone mineral density (BMD) after 12 months of treatment was demonstrated in the randomized, phase III MOVEST study. Read More

    Management of childhood thyroid nodules: Surgical and endocrinological experience in more than one hundred cases.
    J Clin Res Pediatr Endocrinol 2017 Apr 7. Epub 2017 Apr 7.
    Objective: The management of childhood thyroid nodules is still a big challenge for clinicians. In this study, we aimed to present our surgical and endocrinological experience in more than one hundred cases as a large experience in children.

    Methods: Retrospective analysis of patients admitted with a thyroid nodule between 2006-2014 was performed. Read More

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