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    Chronic Kidney Disease and Subclinical Brain Infarction Increase the Risk of Vascular Cognitive Impairment: The Sefuri Study.
    J Stroke Cerebrovasc Dis 2017 Feb 27;26(2):420-424. Epub 2016 Oct 27.
    Center for Emotional and Behavioral Disorders, National Hospital Organization Hizen Psychiatric Center, Kanzaki, Saga, Japan.
    Background And Purpose: The purpose of this study was to determine the complex associations among chronic kidney disease (CKD), subclinical brain infarction (SBI), and cognitive impairment.

    Methods: We used structural equation modeling (SEM) to examine the complex relationships among CKD, SBI, and cognitive function with Mini-Mental State Examination (MMSE; global function) and modified Stroop test (executive function) in a population-based cohort of 560 non-demented elderly subjects.

    Results: Path analysis based on SEM revealed that the direct paths from estimated glomerular filtration rate (eGFR) to SBI and from SBI to executive function were significant (β = -. Read More

    Painful Hashimoto's thyroiditis: myth or reality?
    J Endocrinol Invest 2017 Mar 24. Epub 2017 Mar 24.
    Unit of Internal Medicine and Endocrinology, ICS Maugeri I.R.C.C.S., Chair of Endocrinology, University of Pavia, Via S. Maugeri 10, 27100, Pavia, Italy.
    Neck pain is a common complain, being in most cases due to non-thyroidal causes. However, a minority of patients suffer from painful thyroid diseases. Among them, sub-acute thyroiditis (SAT) is the most frequent one. Read More

    Transarterial (Chemo)Embolization for Liver Metastases in Patients with Neuroendocrine Tumors.
    Oncology 2017 Mar 23. Epub 2017 Mar 23.
    Department of Clinical Oncology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
    Objective: The aim of this study was to evaluate the safety and efficacy of transarterial (chemo)embolization [TA(C)E] for the control of liver metastasis in patients with neuroendocrine tumors (NETs).

    Methods: In this retrospective study, we enrolled 43 patients with metastatic NETs who had been treated with TA(C)E between December 1999 and June 2013 at the National Cancer Center Hospital, Tokyo or the National Cancer Center Hospital East, Kashiwa. We assessed tumor response, time to treatment failure (TTF), overall survival (OS), and frequency of adverse events in these patients, and attempted to identify predictors of TTF. Read More

    Partial tetrasomy 11q resulting from an intrachromosomal triplication of a 22 Mb region of chromosome 11.
    Am J Med Genet A 2017 Apr;173(4):1056-1060
    Departmentof Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohio.
    Intrachromosomal triplications are complex chromosomal rearrangements which arise during meiosis or mitosis and lead to a tetrasomic dose of the affected genomic regions. We describe a female patient harboring an intrachromosomal triplication who presented to the Genetics clinic with dysmorphic features, including telecanthus, flat facial profile, and prognathism, short stature, widely spaced nipples, multiple allergy complaints, loose bowel movements, and mild speech delay. Microarray analysis showed a copy number gain of a 22. Read More

    Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain.
    Mol Neurodegener 2017 Mar 21;12(1):27. Epub 2017 Mar 21.
    Alzheimer Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114, 16th St., Charlestown, MA, 02129, USA.
    Background: Amyloid-β oligomers (oAβ) are thought to mediate neurotoxicity in Alzheimer's disease (AD), and previous studies in AD transgenic mice suggest that calcium dysregulation may contribute to these pathological effects. Even though AD mouse models remain a valuable resource to investigate amyloid neurotoxicity, the concomitant presence of soluble Aβ species, fibrillar Aβ, and fragments of amyloid precursor protein (APP) complicate the interpretation of the phenotypes.

    Method: To explore the specific contribution of soluble oligomeric Aβ (oAβ) to calcium dyshomeostasis and synaptic morphological changes, we acutely exposed the healthy mouse brain, at 3 to 6 months of age, to naturally occurring soluble oligomers and investigated their effect on calcium levels using in vivo multiphoton imaging. Read More

    Genes outside the major histocompatibility complex (MHC) locus are linked to the development of thyroid autoantibodies and thyroiditis in NOD.H2h4 mice.
    Endocrinology 2017 Jan 17. Epub 2017 Jan 17.
    Thyroid Autoimmune Disease Unit, Cedars-Sinai Medical Center and UCLA School of Medicine, 8700 Beverly Blvd, Suite B-131, Los Angeles, CA, USA.
    Thyroiditis and autoantibodies to thyroglobulin (TgAb) and thyroid peroxidase (TPOAb) develop spontaneously in NOD.H2h4 mice, a phenotype enhanced by dietary iodine. NOD. Read More

    The recency ratio is associated with reduced CSF glutamate in late-life depression.
    Neurobiol Learn Mem 2017 Mar 18;141:14-18. Epub 2017 Mar 18.
    Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA; Department of Psychiatry, School of Medicine, New York University, New York City, NY, USA.
    Glutamate is the principal excitatory neurotransmitter in the central nervous system, and is thought to be involved in the process of memory encoding and storage. Glutamate disturbances have also been reported in psychiatric disorders, such as schizophrenia and major depressive disorder (MDD), and in Alzheimer's disease. In this paper, we set out to study the relationship between cerebrospinal fluid (CSF) glutamate levels and memory performance, which we believe has not been reported previously. Read More

    Combined use of dopamine transporter imaging (DAT-SPECT) and (123)I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy for diagnosing Parkinson's disease.
    J Neurol Sci 2017 Apr 14;375:80-85. Epub 2017 Jan 14.
    Department of Radiology, Tokai University Hospital, 143 Simokasuya, Isehara 259-1193, Japan.
    Background: To examine whether combined use of (123)I-FP-CIT dopamine transporter single photon emission computed tomography (DAT-SPECT) and (123)I-MIBG myocardial scintigraphy (MIBG) is superior to either modality alone for diagnosing Parkinson's disease (PD).

    Methods: Patients with probable PD (n=120) who underwent both DAT-SPECT and MIBG myocardial scintigraphy within short intervals were enrolled. Specific binding ratio (SBR) of DAT-SPECT images and heart-to-mediastinum (H/M) ratio of MIBG images were used as quantitative measures. Read More

    Vascular Smooth Muscle Cell Maturation Stage and Ki-67 Index are Diagnostic Biomarkers for Pathologic Grade of Ovarian Teratoma.
    Int J Gynecol Pathol 2017 Mar 17. Epub 2017 Mar 17.
    Departments of Molecular Pathology (M.H.-K., A.K., K.F., M.K.) Anatomic Pathology (T.N.), Tokyo Medical University Department of Diagnostic Pathology, NTT Medical Center Tokyo (H. Hashimoto, H. Horiuchi), Tokyo, Japan.
    Although immature teratoma of the ovary is a rare disease, its pathologic grading, especially between low-grade (grade 1) and high-grade (grade 2 or 3) immature teratomas, is important for optimal therapy and prognosis. This grading, however, is currently solely dependent on quantitation of neuroepithelial components as judged by subjective assessments. As we have recently successfully studied the maturation of vascular smooth muscle cells (SMCs) in other organs using an h-caldesmon to α-smooth muscle actin (α-SMA) ratio, we decided to use this ratio to investigate a potential link between teratoma grade and SMC maturation, in combination with Ki-67 index. Read More

    A concise review of Hashimoto thyroiditis (HT) and the importance of iodine, selenium, vitamin D and gluten on the autoimmunity and dietary management of HT patients.Points that need more investigation.
    Hell J Nucl Med 2017 Mar 20. Epub 2017 Mar 20.
    Department of Internal Medicine, Naval Hospital of Crete, Chania, Greece.
    Hashimoto's thyroiditis (HT) is a chronic autoimmune thyroid disease caused by an interaction between genetic factors and environmental conditions, both of which are yet to be fully understood. The management of HT depends on its clinical manifestations, commonly including diffuse or nodular goiter with euthyroidism, subclinical hypothyroidism and permanent hypothyroidism. However, in most cases of patients with HT, lifelong levothyroxine substitution is required. Read More

    Adjuvant Chemotherapy with S-1 plus Cisplatin for Patients with Stage III Gastric Cancer After Curative Resection.
    Anticancer Res 2017 Mar;37(3):1329-1333
    Department of Surgery, New Tokyo Hospital, Chiba, Japan.
    Background/aim: The aim of this study was to investigate the efficacy and safety of S-1 plus low-dose cisplatin for stage IIIB and stage IIIC gastric cancer patients after D2 gastrectomy.

    Patients And Methods: The study group comprised of 52 patients. In the first cycle, S-1 (80 mg/m(2)) was administered daily for 3 weeks, followed by 2 weeks of rest; low-dose cisplatin (10 mg) was administered on days 1-5 and 8-12. Read More

    HIF1α in aortic aneurysms and beyond.
    Clin Sci (Lond) 2017 Apr;131(7):621-623
    Cardiovascular Research Center, Department of Anatomy and Cell Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, U.S.A.
    Abdominal aortic aneurysm (AAA) is a permanent expansion of the vessel wall with a high prevalence in those 65 years of age and older. Aneurysms are prone to dissection and rupture that carry a mortality rate of over 85%. Currently, surgical repair is the only option to treat this disease. Read More

    Concomitant expression of ezrin and HER2 predicts distant metastasis and poor prognosis of patients with salivary gland carcinomas.
    Hum Pathol 2017 Mar 11. Epub 2017 Mar 11.
    Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan. Electronic address:
    Salivary gland carcinomas (SGCs) exhibit heterogeneous biological behaviors, including the formation of distant metastases, which is a critical event associated with poor prognosis. Ezrin, which is a member of the ezrin-radixin-moesin family of plasma membrane-cytoskeleton linker proteins, may provide a marker for metastasis and poor survival of patients with cancer. The aim of the present study was to investigate the relationship between ezrin expression and the expression of HER2, p53, and Ki-67 as well as clinicopathological factors in SGCs. Read More

    The impact of evacuation on the incidence of chronic kidney disease after the Great East Japan Earthquake: The Fukushima Health Management Survey.
    Clin Exp Nephrol 2017 Mar 15. Epub 2017 Mar 15.
    Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima, Japan.
    Background: About 146,000 people were forced into long-term evacuation due to the nuclear power plant accident caused by the Great East Japan Earthquake in 2011. Disaster is known to induce hypertension in survivors for a certain period, but it is unclear whether prolonged disaster stress influences chronic kidney disease (CKD). We conducted an observational cohort study to elucidate the effects of evacuation stress on CKD incidence. Read More

    Fibroblast-led cancer cell invasion is activated by epithelial-mesenchymal transition through platelet-derived growth factor BB secretion of lung adenocarcinoma.
    Cancer Lett 2017 Mar 9;395:20-30. Epub 2017 Mar 9.
    Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan; Laboratory of Cancer Biology, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba, 277-8561, Japan. Electronic address:
    Cancer-associated fibroblast (CAF)-dependent local invasion is the process by which cancer cells invade the extracellular matrix using tracks that have been physically remodeled by CAFs. In the present study, we investigated the process by which the epithelial-mesenchymal transition (EMT) of cancer cells affect CAF-dependent local invasion. Using an in vitro collagen invasion assay, we showed cancer cells undergoing EMT to promote the matrix-remodeling ability of CAFs and thereby enhance CAF-dependent local cancer cell invasion. Read More

    The utility of apoptosis inhibitor of macrophages as a possible diagnostic marker in patients with Crohn's disease.
    BMC Gastroenterol 2017 Mar 11;17(1):40. Epub 2017 Mar 11.
    Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.
    Background: Apoptosis inhibitor of macrophages (AIM) was initially identified as an apoptosis inhibitor that supports the survival of macrophages against various apoptosis-inducing stimuli, and AIM produced by macrophages may contribute to the pathogenesis of inflammatory bowel diseases (IBDs). However, there have been no reports on the kinetics of AIM in IBD and the impact of AIM on the pathogenesis of IBD. In this study, we aimed to investigate the diagnostic utility of levels of AIM and their correlation with the activity of Crohn's disease (CD) and IBD. Read More

    Hashimoto's thyroiditis: Relative recurrence risk ratio and implications for screening of first degree relatives.
    Clin Endocrinol (Oxf) 2017 Mar 8. Epub 2017 Mar 8.
    Department of Endocrinology, Seth GSMC and KEM Hospital, Parel, Mumbai, 400091.
    Context: The relative recurrence risk ratio (λR ) for Hashimoto's thyroiditis (HT) has not been widely studied. The age at which thyroid function evaluation should be initiated for relatives of HT patients remains unclear.

    Objective: To study λR and age-related prevalence of HT in first degree relatives of HT patients. Read More

    Type B Insulin Resistance in Peru.
    Am J Med Sci 2017 Mar 30;353(3):258-262. Epub 2016 Aug 30.
    Endocrinology Unit, Hospital Nacional Arzobispo Loayza, Lima, Peru.
    Type B insulin resistance (IR) is a rare autoimmune disease characterized by the presence of insulin receptor autoantibodies, resulting in a marked IR inducing hyperglycemia. Our first case is a 42-year-old female with a history of RA, SLE and Hashimoto-thyroiditis that presented with cachexia, acanthosis-nigricans, hirsutism, negative anti-insulin-ab and glucose level between 400 to 700 mg/dl, despite a total insulin dose of 1000 IU/day. She received pulses of cyclophosphamide along with prednisone. Read More

    The discrepancy between serum creatinine and cystatin C can predict renal function after treatment for postrenal acute kidney injury: multicenter study and pooled data analysis.
    Clin Exp Nephrol 2017 Mar 3. Epub 2017 Mar 3.
    Department of Urology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo, 060-8543, Japan.
    Background: Although serum cystatin C and creatinine are used as practical markers of renal function, the discrepancy between them in postrenal acute kidney injury (AKI) cases was reported. The aim of this study was to determine whether the preoperative serum cystatin C (pre-CysC) level could predict clinical outcomes after treatment in patients with postrenal AKI.

    Methods: Patients who underwent urological interventions with postrenal AKI were enrolled in this prospective observational study. Read More

    Selenium supplementation modulates apoptotic processes in thyroid follicular cells.
    Biofactors 2017 Mar 2. Epub 2017 Mar 2.
    Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli "Federico II", Napoli, 80131, Italy.
    Selenium (Se) is an essential micronutrient modulating several physiopathological processes in the human body. The aim of the study is to characterize the molecular effects determined by Se-supplementation in thyroid follicular cells, using as model the well-differentiated rat thyroid follicular cell line FRTL5. Experiments have been performed to evaluate the effects of Se on cell growth, mortality and proliferation and on modulation of pro- and antiapoptotic pathways. Read More

    The Relationship between the Growth Hormone/Insulin-like Growth Factor System and the Histological Features of Nonalcoholic Fatty Liver Disease.
    Intern Med 2017 1;56(5):473-480. Epub 2017 Mar 1.
    Department of Gastroenterology and Internal Medicine, Tokyo Women's Medical University, Japan.
    Objective Growth hormone (GH) deficiency has recently been reported as a cause of nonalcoholic fatty liver disease (NAFLD), and GH supplementation has been shown to improve the histology of NAFLD. The aim of the present study was to clarify the relationship between the histological severity of NAFLD and production of the GH/insulin-like growth factor 1 (IGF-1) axis. Methods A total of 222 Japanese patients with liver biopsy-confirmed NAFLD and 55 patients with hepatitis C virus (HCV)-related chronic liver disease (CLD) were enrolled in the present study. Read More

    Lymph node characteristics for predicting locoregional recurrence of papillary thyroid cancer in adolescents and young adults.
    Oral Oncol 2017 Mar 6;66:22-27. Epub 2017 Jan 6.
    Deparment of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, 253 Gongye Road, Guangzhou, Guangdong Province, China. Electronic address:
    Purpose: To determine lymph node (LN) characteristics predictive of locoregional recurrence (LRR) in adolescent and young adult (AYA) ages 15-39years presenting with papillary thyroid cancer (PTC) and cervical pathologically proven LN metastases (pN1).

    Methods And Materials: Retrospective chart review was performed for all patients with PTC and nodal metastases who had undergone total thyroidectomy, LN dissection, and postoperative radioactive iodine therapy in a university hospital between 2006 and 2014. Clinical and histopathologic markers that were independently associated with tumor recurrence were evaluated. Read More

    Development of ghrelin resistance in a cancer cachexia rat model using human gastric cancer-derived 85As2 cells and the palliative effects of the Kampo medicine rikkunshito on the model.
    PLoS One 2017 1;12(3):e0173113. Epub 2017 Mar 1.
    Division of Cancer Pathophysiology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.
    Cancer cachexia (CC) is a multifactorial disease characterized by decreased food intake and loss of body weight due to reduced musculature with or without loss of fat mass. Patients with gastric cancer have a high incidence of cachexia. We previously established a novel CC rat model induced by human gastric cancer-derived 85As2 cells in order to examine the pathophysiology of CC and identify potential therapeutics. Read More

    Intermittent Ibandronate Maintains Bone Mass, Bone Structure, and Biomechanical Strength of Trabecular and Cortical Bone After Discontinuation of Parathyroid Hormone Treatment in Ovariectomized Rats.
    Calcif Tissue Int 2017 Feb 28. Epub 2017 Feb 28.
    Fuji Gotemba Research Laboratories, Product Research Department, Chugai Pharmaceutical Co., Ltd, 1-135 Komakado, Gotemba, Shizuoka, 412-8513, Japan.
    Although parathyroid hormone (PTH) expresses an anabolic effect on bone mass, the increased bone mass disappears once PTH treatment is withdrawn. Therefore, sequential treatment with anti-bone-resorptive agents is required to maintain bone mass after PTH treatment. We examined the effect of sequential treatment with ibandronate (IBN), a nitrogen-containing bisphosphonate, following PTH in ovariectomized (OVX) rats. Read More

    Early post-treatment choroidal thickness to alert sunset glow fundus in patients with Vogt-Koyanagi-Harada disease treated with systemic corticosteroids.
    PLoS One 2017 27;12(2):e0172612. Epub 2017 Feb 27.
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
    Purpose: To determine if early post-treatment central choroidal thickness (CCT) changes can predict sunset glow fundus (SGF) development in patients with Vogt-Koyanagi-Harada (VKH) disease treated using systemic corticosteroids.

    Methods: This retrospective case series included 39 eyes of 21 treatment-naïve patients with acute VKH disease who could be followed up for more than 12 months after systemic corticosteroid therapy. The eyes were divided into two groups according to whether SGF was present or absent at 12 months (9 eyes of 5 patients versus 30 eyes of 16 patients, respectively). Read More

    Hippocampal atrophy and memory dysfunction associated with physical inactivity in community-dwelling elderly subjects: The Sefuri study.
    Brain Behav 2017 Feb 29;7(2):e00620. Epub 2016 Dec 29.
    Center for Emotional and Behavioral Disorders National Hospital Organization Hizen Psychiatric Center Saga Japan.
    Background: Physical inactivity is one of the modifiable risk factors for hippocampal atrophy and Alzheimer's disease. We investigated the relationship between physical activity, hippocampal atrophy, and memory using structural equation modeling (SEM).

    Materials And Methods: We examined 213 community-dwelling elderly subjects (99 men and 114 women with a mean age of 68. Read More

    Vitiligo and overt thyroid diseases: A nationwide population-based study in Korea.
    J Am Acad Dermatol 2017 Feb 23. Epub 2017 Feb 23.
    Department of Dermatology, College of Medicine, Nowon Eulji Medical Center, Eulji University, Seoul, Korea. Electronic address:
    Background: Associations between vitiligo and thyroid diseases have been reported repeatedly.

    Objective: We investigated the associations between vitiligo and overt autoimmune thyroid diseases and thyroid cancer using the Korean National Health Insurance claims database.

    Methods: We defined patients with vitiligo as those whose records showed ≥4 physician contacts between 2009 and 2013 in which vitiligo was the principal diagnosis. Read More

    The persistence of chronic spontaneous urticaria in childhood is associated with the urticaria activity score.
    Allergy Asthma Proc 2017 03;38(2):136-142
    Background: There is little information regarding the etiology and natural course of chronic spontaneous urticaria (CSU) in childhood.

    Objective: To investigate the etiology, prognosis, and the factors associated with the prognosis of CSU in children.

    Method: Data from children with CSU who had been diagnosed between 1992 and 2015 were analyzed. Read More

    Significance of lymph node metastasis in pancreatic neuroendocrine tumor.
    Surg Today 2017 Feb 22. Epub 2017 Feb 22.
    Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
    Purpose: Pancreatic neuroendocrine tumor (PNET) is relatively rare and has a generally better prognosis than does pancreatic cancer. However, as its prognosis in patients with lymph node metastasis (LNM) is unclear, lymph node dissection for PNET is controversial. Our study aimed to clarify the significance of LNM in PNET. Read More

    RAGE polymorphisms and oxidative stress levels in Hashimoto's thyroiditis.
    Eur J Clin Invest 2017 Feb 22. Epub 2017 Feb 22.
    Endocrine Unit, Department Med Therapeutics, Alexandra Hospital, School of Medicine, National Kapodistrian University, Athens, Greece.
    Background: Polymorphisms of the receptor for advanced glycation end products (RAGE) gene have been studied in various autoimmune disorders, but not in Hashimoto's thyroiditis. Also, increased oxidative stress has been described in patients with Hashimoto's thyroiditis. The aim of this study was to investigate the possible role of two common RAGE polymorphisms (-429T>C, -374T>A) in Hashimoto's thyroiditis; in parallel, we studied oxidative stress levels. Read More

    Nationwide multi-institutional retrospective analysis of high-dose-rate brachytherapy combined with external beam radiotherapy for localized prostate cancer: An Asian Prostate HDR-BT Consortium.
    Brachytherapy 2017 Feb 17. Epub 2017 Feb 17.
    Department of Radiology and Radiation Oncology, Kitasato University School of Medicine, Kanagawa, Japan.
    Purpose: To report outcomes and risk factors of high-dose-rate (HDR) brachytherapy combined with external beam radiotherapy with or without androgen deprivation therapy (ADT) in prostate cancer patients.

    Materials And Methods: This multi-institutional retrospective analysis comprised 3424 patients with localized prostate cancer at 16 Asian hospitals. One-thirds (27. Read More

    Binding of (11)C-Pittsburgh compound-B correlated with white matter injury in hypertensive small vessel disease.
    Ann Nucl Med 2017 Apr 20;31(3):227-234. Epub 2017 Feb 20.
    Department of Cerebrovascular medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
    Objective: (11)C-Pittsburgh compound-B ((11)C-PIB) positron emission tomography (PET) is used to visualize and quantify amyloid deposition in the brain cortex in pathological conditions such as Alzheimer's disease (AD). Intense (11)C-PIB retention is also observed in the white matter (WM) of both healthy individuals and AD patients. However, the clinical implications of this retention in brain WM have not been clarified. Read More

    Bullous pemphigoid arising in a patient with acquired perforating dermatosis.
    Clin Exp Dermatol 2017 Feb 20. Epub 2017 Feb 20.
    Department of Dermatology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan.
    A middle-aged Japanese man who had been on haemodialysis treatment for diabetic nephropathy developed multiple itchy papules and nodules, which were histopathologically diagnosed as acquired perforating dermatosis. Two years later he developed oral lesions and subsequently numerous erosive plaques with necrotic crusts on the trunk and extremities. Histopathology of a papule showed a parakeratotic plug intermingled with basophilic, necrotic debris and collagen bundles, along with penetration of collagen bundles across the epidermis and subepidermal blister. Read More

    Improving iodine nutritional status and increasing prevalence of autoimmune thyroiditis in children.
    Indian J Endocrinol Metab 2017 Jan-Feb;21(1):85-89
    Department of Pediatrics, CSI Hospital, Bengaluru, Karnataka, India.
    Objective: The objective of this study is to evaluate the link between excess iodine intake as evidenced by increased urinary iodine excretion (UIE) and autoimmune thyroiditis in children and to assess the correlation between UIE and thyroid microsomal antibody (thyroid peroxidase [TPO]) titers in children.

    Materials And Methods: All children with goiter between age group 6 and 12 years, were subjected to blood tests for free thyroxine, thyroid stimulating hormone, and TPO antibody, fine needle aspiration was advised for all children with goiter. Forty-three children with confirmed autoimmune thyroiditis served as cases, and 43 children with euthyroid goiter with workup negative for autoimmune thyroiditis and iodine deficiency were enrolled as controls. Read More

    Surgery for metastatic tumors of the pancreas.
    Surg Case Rep 2017 Dec 18;3(1):31. Epub 2017 Feb 18.
    Department of Gastroenterological Surgery, Kumamoto University Graduate School of Medical Sciences, 1-1-1 Honjo, Kumamoto City, 860-8556, Japan.
    Metastatic lesion of the pancreas originated from other organs is uncommon. The aim of this report was to evaluate the outcome of surgery in patients with isolated metastases to the pancreas. Nine patients underwent pancreatic resection for metastatic malignant disease from 2000 to 2015 at the Department of Gastroenterological Surgery of the Kumamoto University Hospital. Read More

    Elderly-onset hereditary pulmonary alveolar proteinosis and its cytokine profile.
    BMC Pulm Med 2017 Feb 17;17(1):40. Epub 2017 Feb 17.
    Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, Niigata, 951-8520, Japan.
    Background: Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by surfactant accumulation, and is caused by disruption of granulocyte/macrophage colony-stimulating factor (GM-CSF) signaling. Abnormalities in CSF2 receptor alpha (CSF2RA) were reported to cause pediatric hereditary PAP. We report here the first case of CSF2RA-mutated, elderly-onset hereditary (h) PAP. Read More

    Urinary iodine in early pregnancy is associated with subclinical hypothyroidism in Tianjin, China: an observational study.
    BMC Endocr Disord 2017 Feb 17;17(1):10. Epub 2017 Feb 17.
    Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, No154 Anshan Road, Heping District, Tianjin, 300052, China.
    Background: Subclinical hypothyroidism (SH) is associated with adverse obstetric outcomes and neurodevelopment disorders. Both iodine deficiency and excess are associated with SH; however, few data regarding iodine nutrition status of pregnant women with SH are available. This study aimed to clarify whether iodine deficiency or excess is associated with SH, especially, when test results for anti-thyroid autoantibodies are negative. Read More

    Risk factors of human herpesvirus 6 encephalitis/myelitis after allogeneic hematopoietic stem cell transplantation.
    Transpl Infect Dis 2017 Feb 16. Epub 2017 Feb 16.
    Department of Hematology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
    Background: Human herpesvirus 6 (HHV-6) encephalitis/myelitis is now a well-known complication after allogeneic stem cell transplantation (allo-HSCT), particularly after cord blood transplantation (CBT). In this study, we evaluated the risk factors of HHV-6 encephalitis/myelitis.

    Methods: We evaluated 253 patients who received allo-HSCT from 2007 to 2015 at our institute. Read More

    Elevated serum interferon γ-induced protein 10 kDa is associated with TAFRO syndrome.
    Sci Rep 2017 Feb 13;7:42316. Epub 2017 Feb 13.
    Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
    Multicentric Castleman disease (MCD) is a heterogeneous lymphoproliferative disorder. It is characterized by inflammatory symptoms, and interleukin (IL)-6 contributes to the disease pathogenesis. Human herpesvirus 8 (HHV-8) often drives hypercytokinemia in MCD, although the etiology of HHV-8-negative MCD is idiopathic (iMCD). Read More

    Inositol 1,4,5-trisphosphate receptor determines intracellular Ca(2+) concentration in Trypanosoma cruzi throughout its life cycle.
    FEBS Open Bio 2016 Dec 14;6(12):1178-1185. Epub 2016 Oct 14.
    Department of Molecular and Cellular Parasitology Juntendo University School of Medicine Tokyo Japan.
    Regulation of intracellular Ca(2+) concentration ([Ca(2+)]i) is vital for eukaryotic organisms. Recently, we identified a Ca(2+) channel (TcIP 3R) associated with intracellular Ca(2+) stores in Trypanosoma cruzi, the parasitic protist that causes Chagas disease. In this study, we measured [Ca(2+)]i during the parasite life cycle and determined whether TcIP 3R is involved in the observed variations. Read More

    Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile Dermatomyositis.
    Case Rep Oncol 2017 Jan-Apr;10(1):106-111. Epub 2017 Jan 20.
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
    Both long-term administration of immunosuppressive agents and chronic inflammatory conditions, such as autoimmune disease, could be risk factors for the development of cutaneous squamous cell carcinoma (cSCC). In this report, we present a case of recurrent multiple cSCC on the scalp in a patient with juvenile dermatomyositis who had been administered cyclosporine and Predonine since she was a 1-year-old infant. Interestingly, immunohistochemical staining revealed IL-17-producing cells adjacent to IL-17R-expressing atypical keratinocytes. Read More

    Mild Lung Tuberculosis in a Patient Suffering from Status Epilepticus Caused by the Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH).
    Intern Med 2017 15;56(4):429-433. Epub 2017 Feb 15.
    Division of Respiratory Disease, Department of Internal Medicine, The Jikei University School of Medicine, Japan.
    A 76-year-old woman was diagnosed with lung tuberculosis. On the second day of anti-tuberculosis treatment, she became unconscious and developed status epilepticus accompanied by hyponatremia. The hyponatremia was caused by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Read More

    A comparative study of nuclear 8-hydroxyguanosine expression in Autoimmune Thyroid Diseases and Papillary Thyroid Carcinoma and its relationship with p53, Bcl-2 and Ki-67 cancer related proteins.
    Adv Med Sci 2016 Jun 22;62(1):45-51. Epub 2016 Jun 22.
    Laboratory of Analysis, Development and Food Safety, Research Group "Biotechnology and Pathology", National School of Engineers of Sfax, Sfax, Tunisia.
    Purpose: To investigate whether the oxidative stress is involved in the evolution of Graves' disease (GD) and Hashimoto thyroiditis (HT) into Papillary Thyroid Carcinoma (PTC), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and cancer related proteins (Bcl-2, p53 and Ki-67) expressions were evaluated in these pathologies.

    Patients And Methods: Immunohistochemical method was applied on 25 thyroid tissues. Allred score (AS) serving to evaluate the immunostaining is based on a scale from 0 to 8. Read More

    Respiratory impedance is correlated with morphological changes in the lungs on three-dimensional CT in patients with COPD.
    Sci Rep 2017 Feb 8;7:41709. Epub 2017 Feb 8.
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan.
    The forced oscillation technique provides information concerning respiratory impedance, which comprises resistance and reactance of the respiratory system. However, its relationship with morphological changes of the lungs in chronic obstructive pulmonary disease (COPD) remains unclear. Respiratory impedance and spirometric data were evaluated in 98 patients with COPD and 49 reference subjects. Read More

    Fibromyalgia in patients with thyroid autoimmunity: prevalence and relationship with disease activity.
    Clin Rheumatol 2017 Feb 7. Epub 2017 Feb 7.
    Department of Physical Medicine and Rehabilitation, Erzurum Regional Research and Training Hospital, Erzurum, Turkey.
    Fibromyalgia (FM) is a syndrome characterised by chronic musculoskeletal pain, tenderness and other somatic symptoms. The prevalence of FM is approximately 2-7% in the general global population and is 30-40% in the population of Hashimoto thyroiditis (HT) with a structural pathology. In 2010, new classification criteria for FM were proposed, as an alternative to the American College of Rheumatology (ACR) 1990 criteria. Read More

    Aortic calcification burden predicts deterioration of renal function after radical nephrectomy.
    BMC Urol 2017 Feb 6;17(1):13. Epub 2017 Feb 6.
    Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 036-8562, Japan.
    Background: Radical nephrectomy for renal cell carcinoma (RCC) is a risk factor for the development of chronic kidney disease (CKD), and the possibility of postoperative deterioration of renal function must be considered before surgery. We investigated the contribution of the aortic calcification index (ACI) to the prediction of deterioration of renal function in patients undergoing radical nephrectomy.

    Methods: Between January 1995 and December 2012, we performed 511 consecutive radical nephrectomies for patients with RCC. Read More

    The IL15 +96522 A>T functional polymorphism is related to the differentiation of Th17 cells and the severity of Hashimoto's disease.
    Int J Immunogenet 2017 Apr 5;44(2):41-50. Epub 2017 Feb 5.
    Department of Biomedical Informatics, Division of Health Sciences, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
    To clarify the association between the genetic producibility of IL-15, a pro-inflammatory cytokine, and the pathogenesis of autoimmune thyroid diseases (AITDs), we genotyped +96522 A>T and +82889 A>G polymorphisms in the IL15 gene using 127 patients with Hashimoto's disease (HD), including 55 patients with severe HD and 48 patients with mild HD; 130 patients with Graves' disease (GD), including 52 patients with intractable GD and 44 patients with GD in remission; and 79 healthy volunteers. Both the IL15 +96522 A allele and AA genotype were more frequent in patients with severe HD than in those with mild HD. The serum levels of IL-15 were higher in individuals with the IL15 +96522 AA genotype than in those with the T allele, and they were also higher in patients with severe HD than in those with mild HD. Read More

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