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    The persistence of chronic spontaneous urticaria in childhood is associated with the urticaria activity score.
    Allergy Asthma Proc 2017 Mar;38(2):136-142
    Background: There is little information regarding the etiology and natural course of chronic spontaneous urticaria (CSU) in childhood.

    Objective: To investigate the etiology, prognosis, and the factors associated with the prognosis of CSU in children.

    Method: Data from children with CSU who had been diagnosed between 1992 and 2015 were analyzed. Read More

    Significance of lymph node metastasis in pancreatic neuroendocrine tumor.
    Surg Today 2017 Feb 22. Epub 2017 Feb 22.
    Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
    Purpose: Pancreatic neuroendocrine tumor (PNET) is relatively rare and has a generally better prognosis than does pancreatic cancer. However, as its prognosis in patients with lymph node metastasis (LNM) is unclear, lymph node dissection for PNET is controversial. Our study aimed to clarify the significance of LNM in PNET. Read More

    RAGE polymorphisms and oxidative stress levels in Hashimoto's thyroiditis.
    Eur J Clin Invest 2017 Feb 22. Epub 2017 Feb 22.
    Endocrine Unit, Dept Med Therapeutics, Alexandra Hospital, School of Medicine, National Kapodistrian University, Athens, Greece.
    Background: Polymorphisms of the receptor for advanced glycation end products (RAGE) gene have been studied in various autoimmune disorders, but not in Hashimoto's thyroiditis. Also, increased oxidative stress has been described in patients with Hashimoto's thyroiditis. The aim of the present study was to investigate the possible role of two common RAGE polymorphisms (-429T>C, -374T>A) in Hashimoto's thyroiditis; in parallel we studied oxidative stress levels. Read More

    Nationwide multi-institutional retrospective analysis of high-dose-rate brachytherapy combined with external beam radiotherapy for localized prostate cancer: An Asian Prostate HDR-BT Consortium.
    Brachytherapy 2017 Feb 17. Epub 2017 Feb 17.
    Department of Radiology and Radiation Oncology, Kitasato University School of Medicine, Kanagawa, Japan.
    Purpose: To report outcomes and risk factors of high-dose-rate (HDR) brachytherapy combined with external beam radiotherapy with or without androgen deprivation therapy (ADT) in prostate cancer patients.

    Materials And Methods: This multi-institutional retrospective analysis comprised 3424 patients with localized prostate cancer at 16 Asian hospitals. One-thirds (27. Read More

    Binding of (11)C-Pittsburgh compound-B correlated with white matter injury in hypertensive small vessel disease.
    Ann Nucl Med 2017 Feb 20. Epub 2017 Feb 20.
    Department of Cerebrovascular medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
    Objective: (11)C-Pittsburgh compound-B ((11)C-PIB) positron emission tomography (PET) is used to visualize and quantify amyloid deposition in the brain cortex in pathological conditions such as Alzheimer's disease (AD). Intense (11)C-PIB retention is also observed in the white matter (WM) of both healthy individuals and AD patients. However, the clinical implications of this retention in brain WM have not been clarified. Read More

    Bullous pemphigoid arising in a patient with acquired perforating dermatosis.
    Clin Exp Dermatol 2017 Feb 20. Epub 2017 Feb 20.
    Department of Dermatology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan.
    A middle-aged Japanese man who had been on haemodialysis treatment for diabetic nephropathy developed multiple itchy papules and nodules, which were histopathologically diagnosed as acquired perforating dermatosis. Two years later he developed oral lesions and subsequently numerous erosive plaques with necrotic crusts on the trunk and extremities. Histopathology of a papule showed a parakeratotic plug intermingled with basophilic, necrotic debris and collagen bundles, along with penetration of collagen bundles across the epidermis and subepidermal blister. Read More

    Improving iodine nutritional status and increasing prevalence of autoimmune thyroiditis in children.
    Indian J Endocrinol Metab 2017 Jan-Feb;21(1):85-89
    Department of Pediatrics, CSI Hospital, Bengaluru, Karnataka, India.
    Objective: The objective of this study is to evaluate the link between excess iodine intake as evidenced by increased urinary iodine excretion (UIE) and autoimmune thyroiditis in children and to assess the correlation between UIE and thyroid microsomal antibody (thyroid peroxidase [TPO]) titers in children.

    Materials And Methods: All children with goiter between age group 6 and 12 years, were subjected to blood tests for free thyroxine, thyroid stimulating hormone, and TPO antibody, fine needle aspiration was advised for all children with goiter. Forty-three children with confirmed autoimmune thyroiditis served as cases, and 43 children with euthyroid goiter with workup negative for autoimmune thyroiditis and iodine deficiency were enrolled as controls. Read More

    Surgery for metastatic tumors of the pancreas.
    Surg Case Rep 2017 Dec 18;3(1):31. Epub 2017 Feb 18.
    Department of Gastroenterological Surgery, Kumamoto University Graduate School of Medical Sciences, 1-1-1 Honjo, Kumamoto City, 860-8556, Japan.
    Metastatic lesion of the pancreas originated from other organs is uncommon. The aim of this report was to evaluate the outcome of surgery in patients with isolated metastases to the pancreas. Nine patients underwent pancreatic resection for metastatic malignant disease from 2000 to 2015 at the Department of Gastroenterological Surgery of the Kumamoto University Hospital. Read More

    Paraneoplastic pemphigus associated with Castleman disease: Progression from mucous to mucocutaneous lesions with epitope-spreading phenomena.
    Br J Dermatol 2017 Feb 18. Epub 2017 Feb 18.
    Departments of Dermatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.
    Paraneoplastic pemphigus (PNP) is a frequently fatal autoimmune blistering disease of the skin and mucous membranes.(1) PNP is commonly associated with malignant neoplasms or haematological disorders like Castleman disease (CD). The eruptions may resemble those seen in various other conditions such as lichen planus (LP), graft-versus-host disease, erythema multiforme (EM), bullous pemphigoid and pemphigus vulgaris (PV). Read More

    Elderly-onset hereditary pulmonary alveolar proteinosis and its cytokine profile.
    BMC Pulm Med 2017 Feb 17;17(1):40. Epub 2017 Feb 17.
    Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, Niigata, 951-8520, Japan.
    Background: Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by surfactant accumulation, and is caused by disruption of granulocyte/macrophage colony-stimulating factor (GM-CSF) signaling. Abnormalities in CSF2 receptor alpha (CSF2RA) were reported to cause pediatric hereditary PAP. We report here the first case of CSF2RA-mutated, elderly-onset hereditary (h) PAP. Read More

    Urinary iodine in early pregnancy is associated with subclinical hypothyroidism in Tianjin, China: an observational study.
    BMC Endocr Disord 2017 Feb 17;17(1):10. Epub 2017 Feb 17.
    Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, No154 Anshan Road, Heping District, Tianjin, 300052, China.
    Background: Subclinical hypothyroidism (SH) is associated with adverse obstetric outcomes and neurodevelopment disorders. Both iodine deficiency and excess are associated with SH; however, few data regarding iodine nutrition status of pregnant women with SH are available. This study aimed to clarify whether iodine deficiency or excess is associated with SH, especially, when test results for anti-thyroid autoantibodies are negative. Read More

    Risk factors of human herpesvirus 6 encephalitis/myelitis after allogeneic hematopoietic stem cell transplantation.
    Transpl Infect Dis 2017 Feb 16. Epub 2017 Feb 16.
    Department of Hematology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
    Background: Human herpesvirus 6 (HHV-6) encephalitis/myelitis is now a well-known complication after allogeneic stem cell transplantation (allo-HSCT), particularly after cord blood transplantation (CBT). In this study, we evaluated the risk factors of HHV-6 encephalitis/myelitis.

    Methods: We evaluated 253 patients who received allo-HSCT from 2007 to 2015 at our institute. Read More

    Elevated serum interferon γ-induced protein 10 kDa is associated with TAFRO syndrome.
    Sci Rep 2017 Feb 13;7:42316. Epub 2017 Feb 13.
    Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
    Multicentric Castleman disease (MCD) is a heterogeneous lymphoproliferative disorder. It is characterized by inflammatory symptoms, and interleukin (IL)-6 contributes to the disease pathogenesis. Human herpesvirus 8 (HHV-8) often drives hypercytokinemia in MCD, although the etiology of HHV-8-negative MCD is idiopathic (iMCD). Read More

    Inositol 1,4,5-trisphosphate receptor determines intracellular Ca(2+) concentration in Trypanosoma cruzi throughout its life cycle.
    FEBS Open Bio 2016 Dec 14;6(12):1178-1185. Epub 2016 Oct 14.
    Department of Molecular and Cellular Parasitology Juntendo University School of Medicine Tokyo Japan.
    Regulation of intracellular Ca(2+) concentration ([Ca(2+)]i) is vital for eukaryotic organisms. Recently, we identified a Ca(2+) channel (TcIP 3R) associated with intracellular Ca(2+) stores in Trypanosoma cruzi, the parasitic protist that causes Chagas disease. In this study, we measured [Ca(2+)]i during the parasite life cycle and determined whether TcIP 3R is involved in the observed variations. Read More

    Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile Dermatomyositis.
    Case Rep Oncol 2017 Jan-Apr;10(1):106-111. Epub 2017 Jan 20.
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
    Both long-term administration of immunosuppressive agents and chronic inflammatory conditions, such as autoimmune disease, could be risk factors for the development of cutaneous squamous cell carcinoma (cSCC). In this report, we present a case of recurrent multiple cSCC on the scalp in a patient with juvenile dermatomyositis who had been administered cyclosporine and Predonine since she was a 1-year-old infant. Interestingly, immunohistochemical staining revealed IL-17-producing cells adjacent to IL-17R-expressing atypical keratinocytes. Read More

    Mild Lung Tuberculosis in a Patient Suffering from Status Epilepticus Caused by the Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH).
    Intern Med 2017 15;56(4):429-433. Epub 2017 Feb 15.
    Division of Respiratory Disease, Department of Internal Medicine, The Jikei University School of Medicine, Japan.
    A 76-year-old woman was diagnosed with lung tuberculosis. On the second day of anti-tuberculosis treatment, she became unconscious and developed status epilepticus accompanied by hyponatremia. The hyponatremia was caused by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Read More

    A comparative study of nuclear 8-hydroxyguanosine expression in Autoimmune Thyroid Diseases and Papillary Thyroid Carcinoma and its relationship with p53, Bcl-2 and Ki-67 cancer related proteins.
    Adv Med Sci 2016 Jun 22;62(1):45-51. Epub 2016 Jun 22.
    Laboratory of Analysis, Development and Food Safety, Research Group "Biotechnology and Pathology", National School of Engineers of Sfax, Sfax, Tunisia.
    Purpose: To investigate whether the oxidative stress is involved in the evolution of Graves' disease (GD) and Hashimoto thyroiditis (HT) into Papillary Thyroid Carcinoma (PTC), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and cancer related proteins (Bcl-2, p53 and Ki-67) expressions were evaluated in these pathologies.

    Patients And Methods: Immunohistochemical method was applied on 25 thyroid tissues. Allred score (AS) serving to evaluate the immunostaining is based on a scale from 0 to 8. Read More

    Respiratory impedance is correlated with morphological changes in the lungs on three-dimensional CT in patients with COPD.
    Sci Rep 2017 Feb 8;7:41709. Epub 2017 Feb 8.
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan.
    The forced oscillation technique provides information concerning respiratory impedance, which comprises resistance and reactance of the respiratory system. However, its relationship with morphological changes of the lungs in chronic obstructive pulmonary disease (COPD) remains unclear. Respiratory impedance and spirometric data were evaluated in 98 patients with COPD and 49 reference subjects. Read More

    Fibromyalgia in patients with thyroid autoimmunity: prevalence and relationship with disease activity.
    Clin Rheumatol 2017 Feb 7. Epub 2017 Feb 7.
    Department of Physical Medicine and Rehabilitation, Erzurum Regional Research and Training Hospital, Erzurum, Turkey.
    Fibromyalgia (FM) is a syndrome characterised by chronic musculoskeletal pain, tenderness and other somatic symptoms. The prevalence of FM is approximately 2-7% in the general global population and is 30-40% in the population of Hashimoto thyroiditis (HT) with a structural pathology. In 2010, new classification criteria for FM were proposed, as an alternative to the American College of Rheumatology (ACR) 1990 criteria. Read More

    Aortic calcification burden predicts deterioration of renal function after radical nephrectomy.
    BMC Urol 2017 Feb 6;17(1):13. Epub 2017 Feb 6.
    Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 036-8562, Japan.
    Background: Radical nephrectomy for renal cell carcinoma (RCC) is a risk factor for the development of chronic kidney disease (CKD), and the possibility of postoperative deterioration of renal function must be considered before surgery. We investigated the contribution of the aortic calcification index (ACI) to the prediction of deterioration of renal function in patients undergoing radical nephrectomy.

    Methods: Between January 1995 and December 2012, we performed 511 consecutive radical nephrectomies for patients with RCC. Read More

    Erratum: Diagnostic difficulties by the unusual presentations in children and adolescents with Hashimoto thyroiditis.
    Ann Pediatr Endocrinol Metab 2016 Dec 31;21(4):245. Epub 2016 Dec 31.
    Division of Pediatric Cardiology, Department of Pediatrics, School of Medicine, Celal Bayar University, Manisa, Turkey.
    [This corrects the article on p. 164 in vol. 21, PMID: 27777910. Read More

    A young female with urinary retention - A case report of Hashimoto's Encephalopathy.
    Am J Emerg Med 2017 Jan 26. Epub 2017 Jan 26.
    McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Department of Internal Medicine, United States.
    Hashimoto's Encephalopathy (HE) is a rare form of autoimmune encephalopathy associated with Hashimoto's thyroiditis in which patients experience cognitive impairment and various neurologic symptoms. We present a case of a young female that presented to the emergency department with urinary retention, and was ultimately diagnosed with HE. Examination was significant for direction-changing and vertical nystagmus (direction-changing nystagmus describes a phenomenon where the fast beat changes with the direction of gaze), hyperreflexia, clonus, and Babinski and Hoffman's reflexes (all upper motor neuron (UMN) signs). Read More

    Clinical characteristics and prognosis of non-B, non-C hepatocellular carcinoma: The impact of patient sex on disease-free survival - A retrospective cohort study.
    Int J Surg 2017 Feb 1;39:206-213. Epub 2017 Feb 1.
    Department of Gastroenterological and Transplant Surgery, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8557, Japan.
    Background: The number of patients with hepatocellular carcinoma (HCC) negative for both hepatitis B virus surface antigen (HBsAg) and hepatitis C virus antibody (HCVAb) has increased recently. The purpose of the present study was to investigate the clinical characteristics and prognoses of non-B non-C HCC (NBNC-HCC) patients.

    Materials And Methods: From January 2000 to December 2013, 154 patients with NBNC-HCC and 560 patients with HBsAg or HCVAb positive (BC)-HCC who underwent curative resection were analyzed retrospectively. Read More

    Analysis of the Risk Factors for Severe Oral Mucositis in Head and Neck Cancer after Chemoradiotherapy with S-1.
    Yakugaku Zasshi 2017 ;137(2):221-225
    Departmant of Hospital Pharmaceutics, School of Pharmacy, Showa University.
     Radiotherapy (RT) and chemoradiotherapy (CRT) is widely accepted as the standard treatment for head and neck cancer (HNC). Oral mucositis (OM) often develops as an adverse reaction in HNC patients that receive RT or CRT involving S-1. However, little is known about the risk factors for OM in HNC patients. Read More

    Clinical significance of the radiological severity score in Mycobacterium avium complex lung disease patients.
    Int J Tuberc Lung Dis 2017 Jan 26. Epub 2017 Jan 26.
    Department of Respiratory Medicine, Kurashiki Central Hospital, Kurashiki, Japan.

    SETTING:

    Practical methods for assessing the radiographic findings of Mycobacterium avium complex lung disease (MAC-LD) have not been established.

    OBJECTIVE:

    To identify a correlation between the radiological score and semi-quantitative culture results of respiratory samples, and to assess the prognostic impact of this radiological score in MAC-LD patients.

    DESIGN:

    We retrospectively studied 218 MAC-LD patients. Read More


    Characterization of a murine model with arteritis induced by Nod1 ligand, FK565: a comparative study with a CAWS-induced model.
    Mod Rheumatol 2017 Feb 2:1-19. Epub 2017 Feb 2.
    b Department of Pediatrics , Nippon Medical School , Tokyo , Japan.
    Objective: Kawasaki disease (KD) occurs via activation of the innate immune system. Nucleotide oligomerization domain -1 (NOD1) is a pattern recognition receptor regulating the innate immunity. We characterized histopathology of arteritis induced by FK565, a ligand for NOD1, in mice, compared with Candida albicans water-soluble fraction (CAWS)-induced model. Read More

    FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B cell acute leukemia.
    Blood 2017 Jan 31. Epub 2017 Jan 31.
    Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan;
    FZR1 (fizzy-related protein homolog, also called CDH1, cell division cycle 20 related 1) functions in the cell cycle as a specific activator of APC/C (anaphase-promoting complex or cyclosome) ubiquitin ligase, regulating late mitosis, G1 phase and activation of the G2-M checkpoint. FZR1 has been implicated as both a tumor suppressor and oncoprotein, and its precise contribution to carcinogenesis remains unclear. Here, we examined the role of FZR1 in tumorigenesis and cancer therapy by analyzing tumor models and patient specimens. Read More

    Effect of evacuation on liver function after the Fukushima Daiichi Nuclear Power Plant accident: The Fukushima Health Management Survey.
    J Epidemiol 2017 Jan 27. Epub 2017 Jan 27.
    Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima, Japan; Department of Gastroenterology, Fukushima Medical University School of Medicine, Fukushima, Japan.
    Background: The Great East Japan Earthquake and subsequent Fukushima Daiichi Nuclear Power Plant accident caused residents to switch from their normal lives to lives focused on evacuation. We evaluated liver function before and after this disaster to elucidate the effects of evacuation on liver function.

    Methods: This study was a longitudinal survey of 26,006 Japanese men and women living near the Fukushima Daiichi Nuclear Power Plant. Read More

    Orthopedic, ophthalmic, and psychiatric diseases primarily affect activity limitation for Japanese males and females: Based on the Comprehensive Survey of Living Conditions.
    J Epidemiol 2017 Feb 15;27(2):75-79. Epub 2016 Nov 15.
    Department of Hygiene, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
    Background: Healthy life expectancy (HLE) is used as one of the primary objectives of fundamental health promotion plans and social development plans. Activity limitation is used to calculate HLE, but little study has been done to identify determinants of activity limitation in order to extend HLE. The purpose of this study is to identify diseases and injuries that commonly lead to activity limitation to prioritize countermeasures against activity limitation. Read More

    Reduction of Severity of Recurrent Psychotic Episode by Sustained Treatment with Aripiprazole in a Schizophrenic Patient with Dopamine Supersensitivity: A Case Report.
    Clin Psychopharmacol Neurosci 2017 Feb;15(1):79-81
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan.
    Dopamine supersensitivity psychosis (DSP) is a type of acute exacerbation of recurrent psychosis caused by long-term treatment with antipsychotics in schizophrenic patients. Although DSP is exceedingly troublesome for clinicians, effective treatment has not yet been established. Based on clinical research and our animal study, we hypothesize that aripiprazole, an atypical antipsychotic, may reduce the exacerbation of recurrent psychotic episodes. Read More

    [Clinico-pathological features of papillary thyroid cancer coexistent with Hashimoto's thyroiditis].
    Orv Hetil 2017 Feb;158(5):178-182
    Patológiai Intézet, Debreceni Egyetem, Általános Orvostudományi Kar Debrecen, Nagyerdei krt. 98., 4032.
    Introduction And Aim: Former studies suggest the frequent coexistence of Hashimoto's thyreoditis with papillary thyroid cancer, frequently featured by multifocal carcinogenesis but lower clinical stages compared to thyroid cancers lacking thyroiditis. We examined the clinico-pathological correlations between Hashimoto's thyroditis and papillary thyroid cancer in our region in the North-Eastern part of Hungary.

    Patients And Method: We included a total of 230 patients with papillary thyroid cancer who underwent thyroid surgery at the Surgical Department of the University of Debrecen. Read More

    Frontal lobe function in elderly patients with Alzheimer's disease and caregiver burden.
    Psychogeriatrics 2017 Jan 28. Epub 2017 Jan 28.
    Department of Psychiatry, Nara Medical University, Kashihara, Japan.
    Aim: Understanding of the relationship between caregiver burden and the degree of behavioural deficits in patients with Alzheimer's disease (AD) is relatively limited. Therefore, it is worthwhile to examine the correlations between the various relevant factors to improve the efficacy of care for patients with AD. The aim of this study was to investigate the specific contributions of frontal lobe dysfunction in AD patients to caregiver burden, while controlling for other predictor variables. Read More

    Cyclin-Dependent Kinase Inhibitor-1-Deficient Mice Are Susceptible to Osteoarthritis Associated With Enhanced Inflammation.
    J Bone Miner Res 2017 Jan 27. Epub 2017 Jan 27.
    Department of Orthopedic Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
    Osteoarthritis (OA) is a multifactorial disease, and recent data suggested that cell cycle-related proteins play a role in OA pathology. Cyclin-dependent kinase (CDK) inhibitor 1 (p21) regulates activation of other CDKs, and recently, we reported that p21 deficiency induced susceptibility to OA induced by destabilization of the medial meniscus (DMM) surgery through STAT3-signaling activation. However, the mechanisms associated with why p21 deficiency led to susceptibility to OA by the STAT3 pathway remain unknown. Read More

    Persistent prevalence of polycythemia among evacuees 4 years after the Great East Japan Earthquake: A follow-up study.
    Prev Med Rep 2017 Mar 12;5:251-256. Epub 2017 Jan 12.
    Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University School of Medicine, Fukushima, Japan.
    We previously reported that the lifestyle of evacuees significantly increased the prevalence of polycythemia compared with non-evacuees at an average of 1.6 years (2011-2012) from the previous annual health checkup before the Great East Japan Earthquake (GEJE). Here we analyzed how the prolonged evacuation affected the prevalence of polycythemia an average of 2. Read More

    Association of CTLA-4 gene polymorphisms -318C/T and +49A/G and Hashimoto's thyroidits in Zahedan, Iran.
    Biomed Rep 2017 Jan 17;6(1):108-112. Epub 2016 Nov 17.
    Genetics of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Sistan and Baluchestan 9816743463, Iran; Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Sistan and Baluchestan 9816743463, Iran.
    Hashimoto's thyroiditis (HT) is a chronic inflammation of the thyroid gland and is known as the most common autoimmune disease. Development of autoimmune destruction of thyroid cells is a multi-step process involving convergence of genetic and environmental factors. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) has an important role in homeostasis and negative regulation of immune responses, and is therefore considered to be a key element in the development of autoimmune diseases. Read More

    Autoimmune diseases and HIV infection: A cross-sectional study.
    Medicine (Baltimore) 2017 Jan;96(4):e5769
    aDépartement de Médecine Interne, Hôpital de la Croix-Rousse, Hospices Civils de Lyon bPôle Information Médicale Evaluation Recherche des Hospices Civils de Lyon cDépartement de Maladies Infectieuses, Hôpital de la Croix-Rousse, Hospices Civils de Lyon dUniversité de Lyon, Université Lyon 1 eDépartement de Médecine Interne, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
    To describe the clinical manifestations, treatments, prognosis, and prevalence of autoimmune diseases (ADs) in human immunodeficiency virus (HIV)-infected patients.All HIV-infected patients managed in the Infectious Diseases Department of the Lyon University Hospitals, France, between January 2003 and December 2013 and presenting an AD were retrospectively included.Thirty-six ADs were found among 5186 HIV-infected patients which represents a prevalence of 0. Read More

    Design and synthesis of potent substrate-based inhibitors of the Trypanosoma cruzi dihydroorotate dehydrogenase.
    Bioorg Med Chem 2017 Feb 9;25(4):1465-1470. Epub 2017 Jan 9.
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan. Electronic address:
    Chagas disease, caused by the parasitic protozoan Trypanosoma cruzi, is the leading cause of heart disease in Latin America. T. cruzi dihydroorotate dehydrogenase (DHODH), which catalyzes the production of orotate, was demonstrated to be essential for T. Read More

    Prognostic relevance of SAMSN1 expression in gastric cancer.
    Oncol Lett 2016 Dec 6;12(6):4708-4716. Epub 2016 Oct 6.
    Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.
    The prognosis for patients with advanced gastric cancer (GC) remains poor. The identification of biomarkers relevant to the recurrence and metastasis of GC is advantageous for stratifying patients and proposing novel molecular targets. In the present study the oncological roles of SAM domain, SH3 domain and nuclear localization signals 1 (SAMSN1), a mediator of B-cell function, were elucidated in GC. Read More

    Plasma miRNA expression profiles in rheumatoid arthritis associated interstitial lung disease.
    BMC Musculoskelet Disord 2017 Jan 19;18(1):21. Epub 2017 Jan 19.
    Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, 18-1 Sakuradai, Minami-ku, Sagamihara, 252-0392, Japan.
    Background: Interstitial lung disease (ILD) is frequently associated with rheumatoid arthritis (RA), and is designated RA-associated ILD (RA-ILD). RA-ILD has a large impact on the prognosis of RA. Here, we investigated the micro RNAs (miRNAs) profiles to determine whether they may be useful for diagnosing RA-ILD. Read More

    [Hashimoto Thyroiditis and Periodontal Disease: A Narrative Review].
    Acta Med Port 2016 Oct 31;29(10):651-657. Epub 2016 Oct 31.
    Departamento de Periodontologia. Faculdade de Medicina Dentária. Universidade do Porto. Porto. Portugal.
    Introduction: Currently there is a growing interest in studying systemic conditions with impact on the periodontium. The aim of this article is to determinate if there is a relation between Hashimoto's thyroiditis and periodontal disease.

    Material And Methods: Founded on periodontology based on evidence and in the combination of the keywords: 'Hashimoto disease'; 'Hypothyroidism'; 'Periodontal disease'; 'Systemic Diseases'; a search and evaluation of articles was conducted in Medline, Scopus and Thomson Reuters databases, selecting 30 articles for integral analysis. Read More

    Immunoglobulin G4-Related Thyroid Diseases.
    Eur Thyroid J 2016 Dec 3;5(4):231-239. Epub 2016 Dec 3.
    Department of Endocrinology and Diabetes, The Alfred Hospital, Monash University, Melbourne, VIC, Australia; Department of Medicine, Monash University, Melbourne, VIC, Australia.
    Immunoglobulin G4-related disease (IgG4-RD) is a new disease category involving many organ systems, including the endocrine system in general and the thyroid in particular. Since an initial association was made between hypothyroidism and autoimmune (IgG4-related) pancreatitis, more forms of IgG4-related thyroid disease (IgG4-RTD) have been recognized. Four subcategories of IgG4-RTD have so far been identified: Riedel thyroiditis (RT), fibrosing variant of Hashimoto thyroiditis (FVHT), IgG4-related Hashimoto thyroiditis, and Graves disease with elevated IgG4 levels. Read More

    Anti-inflammatory effects of luteolin on experimental autoimmune thyroiditis in mice.
    Exp Ther Med 2016 Dec 2;12(6):4049-4054. Epub 2016 Nov 2.
    Jiangsu Key Laboratory of Molecular Medicine, School of Medicine, Nanjing University, Nanjing, Jiangsu 210093, P.R. China; Department of Endodontics, Nanjing Stomatology Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu 210008, P.R. China.
    Hashimoto's thyroiditis (HT) is the most common organ-specific autoimmune disease and is believed to be a predominately T cell-mediated autoimmunity. Signal transducer and activator of transcription (STAT)3 is a crucial transcription factor of T cell-mediated immunity, with key roles in the proliferation and migration of T helper (Th) cells, differentiation of Th cells into Th17 cells, and the balance between Treg cells and Th17 cells. Flavonoid luteolin has been shown to markedly inhibit Tyr705 activation/phosphorylation of STAT3 and exert anti-inflammatory effects in multiple sclerosis. Read More

    Novel genetic loci associated with hippocampal volume.
    Nat Commun 2017 Jan 18;8:13624. Epub 2017 Jan 18.
    Department of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.
    The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Read More

    A systematic review of combinatorial treatment with warming and invigorating drugs and levothyroxine for hypothyroidism caused by Hashimoto disease.
    Ann Transl Med 2016 Dec;4(23):459
    Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
    Background: We used the systematic review method to evaluate the clinical efficacy and safety of combinatorial treatment with warming and invigorating drugs and levothyroxine on hypothyroidism caused by Hashimoto thyroiditis (HT).

    Methods: We set inclusion and exclusion criteria, searched for studies using electronic databases and manual retrieval, selected studies according to the inclusion and exclusion criteria, and assessed the qualities of the included studies according to the Jadad scale. We performed a meta-analysis and analyzed the biases and sensitivities of the results using Revman 5. Read More

    The expression and function of the neonatal Fc receptor in thyrocytes of Hashimoto's thyroiditis.
    Int Immunopharmacol 2017 Mar 10;44:53-60. Epub 2017 Jan 10.
    Department of Endocrinology, Peking University First Hospital, No. 8 Xi Shi Ku Street, Xi Cheng District, Beijing 100034, China.
    Objective: Thyroglobulin (Tg) and thyroid peroxidase (TPO) antibodies (TgAb and TPOAb), which are primarily of the immunoglobulin G (IgG) class, can mediate antibody-dependent cell-mediated cytotoxicity in vitro. However, it is unclear whether any thyrocyte molecules can facilitate the transport and elimination of TgAb and TPOAb. The IgG transport receptor neonatal Fc receptor (FcRn) is a candidate mediator of these processes. Read More

    [Autoimmune diseases of the thyroid gland].
    Internist (Berl) 2017 Jan;58(1):47-58
    Funktionsbereich Spezielle Endokrinologie, Universitätsklinikum Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland.
    Autoimmune diseases of the thyroid gland are considered to be the most frequent cause of thyroid gland disorders. Autoimmune thyroid diseases consist of two subgroups: autoimmune thyroiditis (AIT) and Graves' disease. The AIT is the most common human autoimmune disease. Read More

    Comprehensive association analysis of 27 genes from the GABAergic system in Japanese individuals affected with schizophrenia.
    Schizophr Res 2017 Jan 7. Epub 2017 Jan 7.
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351-0198, Japan. Electronic address:
    Involvement of the gamma-aminobutyric acid (GABA)-ergic system in schizophrenia pathogenesis through disrupted neurodevelopment has been highlighted in numerous studies. However, the function of common genetic variants of this system in determining schizophrenia risk is unknown. We therefore tested the association of 375 tagged SNPs in genes derived from the GABAergic system, such as GABAA receptor subunit genes, and GABA related genes (glutamate decarboxylase genes, GABAergic-marker gene, genes involved in GABA receptor trafficking and scaffolding) in Japanese schizophrenia case-control samples (n=2926; 1415 cases and 1511 controls). Read More

    Idiopathic retroperitoneal fibrosis and its overlap with IgG4-related disease.
    Intern Emerg Med 2017 Jan 9. Epub 2017 Jan 9.
    Nephrology Unit, Parma University Hospital, Via Gramsci 14, 43126, Parma, Italy.
    Retroperitoneal fibrosis (RPF) is a rare disease characterised by fibrous tissue proliferation in the retroperitoneum, with encasement of the ureters and large vessels of the abdomen as the most destructive of potentially severe complications. It can either be idiopathic, or secondary to infections, malignancies, or the use of certain drugs. The idiopathic form accounts for approximately 75% of the cases, and is usually responsive to immunosuppressive therapy. Read More

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