229,448 results match your criteria Harvard heart letter : from Harvard Medical School[Journal]


Neurological recovery following traumatic spinal cord injury: a systematic review and meta-analysis.

J Neurosurg Spine 2019 Feb 15:1-17. Epub 2019 Feb 15.

1Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences.

OBJECTIVEPredicting neurological recovery following traumatic spinal cord injury (TSCI) is a complex task considering the heterogeneous nature of injury and the inconsistency of individual studies. This study aims to summarize the current evidence on neurological recovery following TSCI by use of a meta-analytical approach, and to identify injury, treatment, and study variables with prognostic significance.METHODSA literature search in MEDLINE and EMBASE was performed, and studies reporting follow-up changes in American Spinal Injury Association (ASIA) Impairment Scale (AIS) or Frankel or ASIA motor score (AMS) scales were included in the meta-analysis. Read More

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http://dx.doi.org/10.3171/2018.10.SPINE18802DOI Listing
February 2019

Encore careers: a solution to the unmet need in global neurosurgical care.

J Neurosurg 2019 Feb 15:1-3. Epub 2019 Feb 15.

3George Washington University School of Medicine and Health Sciences, Washington, DC.

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http://dx.doi.org/10.3171/2018.11.JNS183298DOI Listing
February 2019

Assessing the localization accuracy and clinical utility of electric and magnetic source imaging in children with epilepsy.

Clin Neurophysiol 2019 Jan 31;130(4):491-504. Epub 2019 Jan 31.

Laboratory of Children's Brain Dynamics, Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Fetal-Neonatal Neuroimaging Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

Objective: To evaluate the accuracy and clinical utility of conventional 21-channel EEG (conv-EEG), 72-channel high-density EEG (HD-EEG) and 306-channel MEG in localizing interictal epileptiform discharges (IEDs).

Methods: Twenty-four children who underwent epilepsy surgery were studied. IEDs on conv-EEG, HD-EEG, MEG and intracranial EEG (iEEG) were localized using equivalent current dipoles and dynamical statistical parametric mapping (dSPM). Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.009DOI Listing
January 2019

Fish Oil Increases Specialized Pro-resolving Lipid Mediators in PAD (The OMEGA-PAD II Trial).

J Surg Res 2019 Feb 13;238:164-174. Epub 2019 Feb 13.

Division of Vascular and Endovascular Surgery, Department of Surgery, University of California, San Francisco, California. Electronic address:

Background: N-3 polyunsaturated fatty acid (PUFA) supplementation has been associated with reduced mortality and inflammation in patients with cardiovascular disease. There are limited data on the effects of n-3 PUFA supplementation in patients with peripheral artery disease (PAD).

Materials And Methods: The OMEGA-PAD II trial was a double-blinded, randomized, placebo-controlled trial to assess the effect of 3 mo of high-dose oral n-3 PUFA supplementation on inflammation, endothelial function, and walking ability in patients with PAD. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.038DOI Listing
February 2019

Exploring anxiety sensitivity in the relationship between pain intensity and opioid misuse among opioid-using adults with chronic pain.

J Psychiatr Res 2019 Feb 8;111:154-159. Epub 2019 Feb 8.

Department of Psychology, University of Houston, USA; Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, USA; HEALTH Institute, University of Houston, USA. Electronic address:

Opioid misuse is a significant public health problem. Chronic pain is one highly prevalent factor that is strongly associated with increased risk for opioid misuse. Anxiety sensitivity (fear of anxiety related physical sensations) is an individual difference factor consistently linked to pain experience, and separately, heroin use. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.02.004DOI Listing
February 2019

Cannabis for refractory epilepsy in children: A review focusing on CDKL5 Deficiency Disorder.

Epilepsy Res 2019 Feb 5;151:31-39. Epub 2019 Feb 5.

Telethon Kids Institute, University of Western Australia, Perth, WA, Australia(2). Electronic address:

Severe paediatric epilepsies such as CDKL5 Deficiency Disorder (CDD) are extremely debilitating, largely due to the early-onset and refractory nature of the seizures. Existing treatment options are often ineffective and associated with a host of adverse effects, causing those that are affected to seek alternative treatments. Cannabis based products have attracted significant attention over recent years, primarily driven by reports of miraculous cures and a renewed public preference for 'natural' therapies, thus placing intense pressure on health professionals and the government for regulatory change. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.001DOI Listing
February 2019

Evaluation of Radiological Features of the Posterior Communicating Artery and their Impact on Efficacy of Saccular Aneurysm Treatment with the Pipeline Embolization Device: A Case Series Study.

World Neurosurg 2019 Feb 13. Epub 2019 Feb 13.

Neurosurgical Service, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA; Department of Neurosurgery, The National Neuroscience Institute, King Fahad Medical City, Riyadh, Saudi Arabia. Electronic address:

Background And Purpose: Posterior communicating artery segment aneurysms are one of the most frequent intracranial aneurysms. Currently, there is limited literature describing the use of the pipeline embolization device in these aneurysms.

Material And Methods: We conducted a multicenter retrospective review of 3 prospectively-collected databases of patients treated with pipeline between January 2013 and December 2017. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.228DOI Listing
February 2019

Guideline removal of atropine and survival after adult in-hospital cardiac arrest with a non-shockable rhythm.

Resuscitation 2019 Feb 13. Epub 2019 Feb 13.

Research Center for Emergency Medicine, Department of Clinical Medicine, Aarhus Universitsy Hospital, Aarhus, Denmark; Center for Resuscitation Science, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Aim: To determine whether the removal of atropine from the 2010 ACLS guidelines for non-shockable cardiac arrests was associated with a change in survival.

Methods: Using the Get With The Guidelines®-Resuscitation registry, we included adults with an index in-hospital cardiac arrest between 2006 and 2015. The primary outcome was survival to hospital discharge. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.02.002DOI Listing
February 2019

Identification of small molecule inhibitors targeting the Zika virus envelope protein.

Antiviral Res 2019 Feb 13. Epub 2019 Feb 13.

Department of Microbiology and Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address:

The recent emergence of Zika virus, a mosquito-borne flavivirus, in the Americas has shed light on the severe neurological diseases associated with infection, notably congenital microcephaly in newborns and Guillain-Barré syndrome in adults. Despite the recent focus on Zika virus, there are currently no approved vaccines or antiviral therapies available to treat or prevent infection. In this study we established a competitive amplified luminescent proximity homogeneous assay (ALPHAscreen) to identify small molecule inhibitors targeting the envelope protein of Zika virus (Zika E). Read More

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http://dx.doi.org/10.1016/j.antiviral.2019.02.008DOI Listing
February 2019
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Nitroglycerin as a comparative experimental model of migraine pain: from animal to human and back.

Prog Neurobiol 2019 Feb 13. Epub 2019 Feb 13.

Headache Science Center, IRCCS C. Mondino Foundation, Pavia, Italy; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. Electronic address:

Migraine is a disease for which there is still no defined pathophysiological etiology and few translational models. The organic nitrate nitroglycerin has been in use as an experimental model of migraine in both human and animal studies for several years. The drug produces a number of effects within the head, that includes blood vessels, nerves and brain areas that may produce a response similar to a migraine attack in predisposed subjects. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2019.02.002DOI Listing
February 2019

Structural effects of variation in the human clavicle.

Am J Phys Anthropol 2019 Feb 16. Epub 2019 Feb 16.

Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.

Objectives: Purported evolutionary shifts in shoulder structure have been linked to changes in hominin behavior and adaptation. Researchers use clavicle morphology to infer these shifts. However, there is a lack of empirical data underlying such predictive relationships. Read More

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http://dx.doi.org/10.1002/ajpa.23787DOI Listing
February 2019

Expression and Purification of Untagged α-Synuclein.

Methods Mol Biol 2019 ;1948:261-269

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

α-Synuclein (αS) is an abundant neuronal protein which has been implicated, among others, in the pathogenesis of neurodegenerative diseases like Parkinson's disease (PD) and dementia with Lewy bodies (DLB). In fact, αS is the major constituent of Lewy bodies, the primarily proteinaceous inclusions found in the nervous tissue of PD and DLB patients. While its physiological role is unclear, it is believed to be involved in the regulation of synaptic vesicle exocytosis. Read More

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http://dx.doi.org/10.1007/978-1-4939-9124-2_20DOI Listing
January 2019

In Situ Peroxidase Labeling and Mass Spectrometry of Alpha-Synuclein in Rat Cortical Neurons.

Methods Mol Biol 2019 ;1948:235-246

Ann Romney Center for Neurologic Disease, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

In this chapter, we describe a novel ascorbate peroxidase (APEX)-based labeling method that in combination with mass spectrometry identifies proteins in the immediate vicinity of αSyn in living rat cortical neurons. To isolate these interactions, we transduced primary cortical neurons with a lentivirus encoding APEX2 tagged to the C-terminus of alpha-synuclein (αSyn) and under the control of a synapsin promoter. Neural protein lysates were then incubated with streptavidin magnetic beads, washed, eluted from the beads, and digested overnight. Read More

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http://dx.doi.org/10.1007/978-1-4939-9124-2_18DOI Listing
January 2019

Circular Dichroism and Isothermal Titration Calorimetry to Study the Interaction of α-Synuclein with Membranes.

Authors:
Matteo Rovere

Methods Mol Biol 2019 ;1948:123-143

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

α-Synuclein's physiology and pathology have been linked by numerous reports to its ability to bind and remodel membranes, especially at synaptic terminals. It is therefore critical for researchers investigating the determinants of these interactions to rely on methods capable of providing an accurate and complete physicochemical snapshot of the binding events. Circular dichroism (CD) and isothermal titration calorimetry (ITC) are established techniques for the study of binding equilibria in biological systems and, especially when used in combination, allow a thorough characterization of the protein-lipid interplay. Read More

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http://dx.doi.org/10.1007/978-1-4939-9124-2_11DOI Listing
January 2019

Studying α-Synuclein Conformation by Intact-Cell Cross-Linking.

Methods Mol Biol 2019 ;1948:77-91

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

β-Sheet-rich aggregates of α-synuclein (αS) are the hallmark neuropathology of Parkinson's disease (PD) and related synucleinopathies, whereas the native conformations of αS in healthy cells are under debate. Cross-linking analyses in intact cells detect a large portion of endogenous αS in apparent multimeric states, most notably as putative tetramers (αS60) that run around 60 kDa on SDS-PAGE, but also point at the dynamic nature of cellular αS states. Standardization of αS cross-linking methods will facilitate efforts to study the effects of genetic, pharmacological, and environmental factors on αS conformation. Read More

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http://dx.doi.org/10.1007/978-1-4939-9124-2_8DOI Listing
January 2019

Disparity in online health information in pediatric vs. adult surgical conditions.

Pediatr Surg Int 2019 Feb 15. Epub 2019 Feb 15.

Harvard Medical School, Boston, MA, USA.

Background: Although the quality of online health information (OHI) for adult surgical conditions is well described, the availability of quality OHI for pediatric surgical conditions, and the comparison to that of adult surgical OHI, remains undefined.

Methods: Medical and lay terms for 15 pediatric and 15 adult surgical conditions were searched using Google in English. The Health on the Net Foundation, a non-governmental OHI accreditation body, designates approval for quality websites. Read More

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http://dx.doi.org/10.1007/s00383-019-04451-yDOI Listing
February 2019

Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language.

Nat Commun 2019 Feb 15;10(1):883. Epub 2019 Feb 15.

CHU Sainte-Justine Research Center, Montreal, QC, H3T 1C5, Canada.

The original version of this Article contained an error in the spelling of the author Laurence Faivre, which was incorrectly given as Laurence Faive. This has now been corrected in both the PDF and HTML versions of the Article. Read More

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http://dx.doi.org/10.1038/s41467-019-08800-2DOI Listing
February 2019

Degrading proteins in animals: "PROTAC"tion goes in vivo.

Cell Res 2019 Feb 15. Epub 2019 Feb 15.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1038/s41422-019-0144-9DOI Listing
February 2019

The definition of a hemodynamically significant ductus arteriosus.

Pediatr Res 2019 Feb 15. Epub 2019 Feb 15.

Department of Neonatology, Beth Israel Deaconess Medical Center and Department of Pediatrics, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41390-019-0342-7DOI Listing
February 2019

Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection.

Nat Commun 2019 Feb 15;10(1):790. Epub 2019 Feb 15.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 02115, MA, USA.

Understanding the role of rare variants is important in elucidating the genetic basis of human disease. Negative selection can cause rare variants to have larger per-allele effect sizes than common variants. Here, we develop a method to estimate the minor allele frequency (MAF) dependence of SNP effect sizes. Read More

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http://dx.doi.org/10.1038/s41467-019-08424-6DOI Listing
February 2019

Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy.

Nat Commun 2019 Feb 15;10(1):797. Epub 2019 Feb 15.

Instituto de Investigaciones Biomédicas "Alberto Sols", CSIC-UAM, 28029, Madrid, Spain.

FXR1 is an alternatively spliced gene that encodes RNA binding proteins (FXR1P) involved in muscle development. In contrast to other tissues, cardiac and skeletal muscle express two FXR1P isoforms that incorporate an additional exon-15. We report that recessive mutations in this particular exon of FXR1 cause congenital multi-minicore myopathy in humans and mice. Read More

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http://dx.doi.org/10.1038/s41467-019-08548-9DOI Listing
February 2019

Special Section Guest Editorial: Translational Biophotonics.

J Biomed Opt 2019 Feb;24(2):1-2

Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Road East, University of California.

This guest editorial introduces the special section on Translational Biophotonics. Read More

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http://dx.doi.org/10.1117/1.JBO.24.2.021200DOI Listing
February 2019

Parry-Romberg syndrome treatment with fat transfer and a new bleaching formula.

J Cosmet Dermatol 2019 Feb 15. Epub 2019 Feb 15.

ISAPS, Athens, Greece.

Parry-Romberg syndrome is a hemifacial atrophy which can be complicated by melasma. We present two cases of Parry-Romberg syndrome, treated by fat transfer and bleaching of the skin using a modified "Kligman's formula." The atrophy, as well as the skin dyschromia, improved, and the results were stable. Read More

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http://dx.doi.org/10.1111/jocd.12819DOI Listing
February 2019

Clinical Characteristics of Patients with Spondyloarthritis in Japan in Comparison with Other Regions of the World.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From the Immuno-Rheumatology Center, St. Luke's International Hospital, St. Luke's International University; Institute of Rheumatology, Tokyo Women's Medical University; Department of Orthopedic Surgery, Juntendo University School of Medicine; Division of Rheumatology, Department of Rheumatology, Keio University School of Medicine, Tokyo; Department of Orthopedic Surgery, Shiga University of Medical Science, Shiga; Department of Rheumatology, Tonan Hospital, Hokkaido; Department of Orthopedic Surgery, Fujita Health University, Aichi; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo; Department of Rheumatology, Chubu Rosai Hospital, Aichi; Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi; Department of Orthopedics, Osaka Minami Medical Center, Osaka; Department of Rheumatology, Daido Hospital, Aichi; Department of Internal Medicine, Juntendo University Koshigaya Hospital, Saitama; Department of Orthopedic Biomaterial Science, Osaka University Graduate School of Medicine, Osaka, Japan; departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA; Division of Rheumatology, National University Hospital, Singapore; Division of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea; Department of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital and Chang Gung University, Tao-Yuan, Taiwan; Hospital Universitario Reina Sofía/IMIBIC/University of Córdoba, Córdoba, Spain; Department of Rheumatology, Paris Descartes University, Cochin Hospital, Paris, France; INSERM Unit 1183, CRESS, Paris, France; Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. This study was conducted under the umbrella of the International Society for Spondyloarthritis Assessment (ASAS) and the COMOSPA study was supported by the unrestricted grants from Pfizer, AbbVie, and UCB. M.K. received honoraria from AbbVie and Ayumi; K.Y. receives tuition support from Harvard T.H. Chan School of Public Health (partially supported by training grants from Pfizer, Takeda, Bayer, and PhRMA); A.M. has received research grants from Abbvie, Pfizer, and MSD. M. Kishimoto, MD, Immuno-Rheumatology Center, St. Luke's International Hospital, St. Luke's International University; K. Yoshida, MD, MPH, ScD, Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health; N. Ichikawa, MD, Institute of Rheumatology, Tokyo Women's Medical University; H. Inoue, MD, Department of Orthopedic Surgery, Juntendo University School of Medicine; Y. Kaneko, MD, Division of Rheumatology, Department of Rheumatology, Keio University School of Medicine; T. Kawasaki, MD, Department of Orthopedic Surgery, Shiga University of Medical Science; K. Matsui, MD, Department of Rheumatology, Tonan Hospital, M. Morita, MD, Department of Orthopedic Surgery, Fujita Health University; M. Suda, MD, Immuno-Rheumatology Center, St. Luke's International Hospital, St. Luke's International University; K. Tada, MD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; N. Takizawa, MD, Department of Rheumatology, Chubu Rosai Hospital; N. Tamura, MD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; A. Taniguchi, MD, Institute of Rheumatology, Tokyo Women's Medical University; Y. Taniguchi, MD, Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School; S. Tsuji, MD, Department of Orthopedics, Osaka Minami Medical Center; Y. Haji, MD, Department of Rheumatology, Daido Hospital; R. Rokutanda, MD, Immuno-Rheumatology Center, St. Luke's International Hospital, St. Luke's International University; H. Yanaoka, MD, Immuno-Rheumatology Center, St. Luke's International Hospital, St. Luke's International University; P.P. Cheung, MD, Division of Rheumatology, National University Hospital; J. Gu, MD, Division of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; T.H. Kim, MD, Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases; S.F. Luo, MD, Department of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital and Chang Gung University; M. Okada, MD, Immuno-Rheumatology Center, St. Luke's International Hospital, St. Luke's International University; C. López Medina, MD, Hospital Universitario Reina Sofía/IMIBIC/University of Córdoba; A. Molto, MD, Department of Rheumatology, Paris Descartes University, Cochin Hospital, and INSERM Unit 1183, CRESS; M. Dougados, MD, Department of Rheumatology, Paris Descartes University, Cochin Hospital, and INSERM Unit 1183, CRESS; S. Kobayashi, MD, PhD, Department of Internal Medicine, Juntendo University Koshigaya Hospital; D. van der Heijde, MD, Department of Rheumatology, Leiden University Medical Center; T. Tomita, MD, Department of Orthopedic Biomaterial Science, Osaka University Graduate School of Medicine. Address correspondence to Dr. M. Kishimoto, Immuno-Rheumatology Center, St. Luke's International Hospital, St. Luke's International University, 9-1 Akashicho, Chuo-ku, Tokyo, Japan, 104-8560. E-mail: Accepted for publication October 11, 2018.

Objective: To delineate clinical characteristics of patients with spondyloarthritis (SpA) in Japan in comparison to other areas of the world.

Methods: Using the ASAS-COMOSPA (Assessment of Spondyloarthritis international Society-COMOrbidities in SPondyloArthritis) data, an international cross-sectional observational study of patients with SpA, we analyzed information on demographics, disease characteristics, comorbidities, and risk factors. Patients were classified by region: Japan, other Asian countries (China, Singapore, South Korea, Taiwan), and non-Asian countries (Europe, the Americas, Africa). Read More

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http://dx.doi.org/10.3899/jrheum.180412DOI Listing
February 2019

Enlightened PD: A novel treatment for Parkinson disease?

Neurology 2019 Feb 15. Epub 2019 Feb 15.

From the Department of Neurology (A.V.), Massachusetts General Hospital, Harvard Medical School, Boston; and Neuropsychology Section (L.M.), Departments of Psychiatry and Neurology, University Hospital of Patras, University of Patras Medical School, Rio, Greece.

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http://dx.doi.org/10.1212/WNL.0000000000007078DOI Listing
February 2019

Targeting Alterations in the RAF-MEK Pathway.

Cancer Discov 2019 Feb 15. Epub 2019 Feb 15.

-Massachusetts General Hospital Cancer Center and Department of -Medicine, Harvard Medical School, Boston, Massachusetts.

The MAPK pathway is one of the most commonly mutated oncogenic pathways in cancer. Although RAS mutations are the most frequent MAPK alterations, less frequent alterations in downstream components of the pathway, including the RAF and MEK genes, offer promising therapeutic opportunities. In addition to BRAF mutations, for which several approved therapeutic regimens exist, other alterations in the RAF and MEK genes may provide more rare, but tractable, targets. Read More

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http://dx.doi.org/10.1158/2159-8290.CD-18-1321DOI Listing
February 2019

Phase I Study of the Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Navoximod (GDC-0919) Administered with PD-L1 Inhibitor (Atezolizumab) in Advanced Solid Tumors.

Clin Cancer Res 2019 Feb 15. Epub 2019 Feb 15.

Medical Oncology, University of Colorado Anschutz Medical Campus.

Purpose: IDO1 induces immune suppression in T cells through L-tryptophan (Trp) depletion and kyneurinine (Kyn) accumulation in the local tumor microenvironment, suppressing effector T-cells and hyperactivating Tregs. Navoximod is an investigational small molecule inhibitor of IDO1. This Phase I study evaluated safety, tolerability, PK and PD of navoximod in combination with atezolizumab, a PD-L1 inhibitor, in patients with advanced cancer. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-2740DOI Listing
February 2019

STAT4 activation by leukemia inhibitory factor confers a therapeutic effect on intestinal inflammation.

EMBO J 2019 Feb 15. Epub 2019 Feb 15.

Institutes of Biology and Medical Sciences, Soochow University Medical College, Suzhou, Jiangsu, China

T helper 17 (Th17)-cell differentiation triggered by interleukin-6 (IL-6) via STAT3 activation promotes inflammation in inflammatory bowel disease (IBD) patients. However, leukemia inhibitory factor (LIF), an IL-6 family cytokine, restricts inflammation by blocking Th17-cell differentiation via an unknown mechanism. Here, we report that microbiota dysregulation promotes LIF secretion by intestinal epithelial cells (IECs) in a mouse colitis model. Read More

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http://dx.doi.org/10.15252/embj.201899595DOI Listing
February 2019

O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3.

Immunity 2019 Feb 5. Epub 2019 Feb 5.

Department of Microbial Infection and Immunity, Infectious Disease Institute, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

Elevated glucose metabolism in immune cells represents a hallmark feature of many inflammatory diseases, such as sepsis. However, the role of individual glucose metabolic pathways during immune cell activation and inflammation remains incompletely understood. Here, we demonstrate a previously unrecognized anti-inflammatory function of the O-linked β-N-acetylglucosamine (O-GlcNAc) signaling associated with the hexosamine biosynthesis pathway (HBP). Read More

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http://dx.doi.org/10.1016/j.immuni.2019.01.007DOI Listing
February 2019

Spatial and Temporal Mapping of Human Innate Lymphoid Cells Reveals Elements of Tissue Specificity.

Immunity 2019 Feb 11. Epub 2019 Feb 11.

Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Stanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, 10021, USA. Electronic address:

Innate lymphoid cells (ILC) play critical roles in regulating immunity, inflammation, and tissue homeostasis in mice. However, limited access to non-diseased human tissues has hindered efforts to profile anatomically-distinct ILCs in humans. Through flow cytometric and transcriptional analyses of lymphoid, mucosal, and metabolic tissues from previously healthy human organ donors, here we have provided a map of human ILC heterogeneity across multiple anatomical sites. Read More

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http://dx.doi.org/10.1016/j.immuni.2019.01.012DOI Listing
February 2019

Goals-of-Care Conversations for Older Adults With Serious Illness in the Emergency Department: Challenges and Opportunities.

Ann Emerg Med 2019 Feb 12. Epub 2019 Feb 12.

Division of Palliative Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA; Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute, Boston, MA; Department of Medicine, Division of Palliative Medicine, Brigham and Women's Hospital, Boston, MA.

During the last 6 months of life, 75% of older adults with preexisting serious illness, such as advanced heart failure, lung disease, and cancer, visit the emergency department (ED). ED visits often mark an inflection point in these patients' illness trajectories, signaling a more rapid rate of decline. Although most patients are there seeking care for acute issues, many of them have priorities other than to simply live as long as possible; yet without discussion of preferences for treatment, they are at risk of receiving care not aligned with their goals. Read More

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http://dx.doi.org/10.1016/j.annemergmed.2019.01.003DOI Listing
February 2019

Commentary on "Accelerated DNA Methylation Aging in U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study".

Authors:
David Mischoulon

Am J Geriatr Psychiatry 2019 Jan 16. Epub 2019 Jan 16.

Department of Psychiatry (DM), Depression Clinical and Research Program, Massachusetts General Hospital, Boston; Department of Psychiatry (DM), Harvard Medical School, Boston. Electronic address:

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http://dx.doi.org/10.1016/j.jagp.2019.01.008DOI Listing
January 2019

Recombinant Activated Factor VII in Children Undergoing Cardiac Surgery: Remember How and Why to Use It.

J Cardiothorac Vasc Anesth 2019 Jan 25. Epub 2019 Jan 25.

Division of Cardiac Anesthesia, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1053/j.jvca.2019.01.052DOI Listing
January 2019

Transesophageal Echocardiography for Impella Placement and Management.

J Cardiothorac Vasc Anesth 2019 Jan 23. Epub 2019 Jan 23.

Department of Anesthesiology, Pain Medicine, and Critical Care, The Massachusetts General Hospital, Harvard Medical School, Boston, MA. Electronic address:

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http://dx.doi.org/10.1053/j.jvca.2019.01.048DOI Listing
January 2019

Misunderstood food date labels and reported food discards: A survey of U.S. consumer attitudes and behaviors.

Waste Manag 2019 Feb 7. Epub 2019 Feb 7.

Food Law and Policy Clinic, Harvard University Law School, 1607 Massachusetts Avenue, Cambridge, MA 02138, USA. Electronic address:

Introduction: Food date labels such as "best before" and "sell by" are largely unregulated in the United States (U.S.), although new voluntary standards are coming into effect. Read More

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http://dx.doi.org/10.1016/j.wasman.2019.01.023DOI Listing
February 2019

Intersectional decomposition analysis with differential exposure, effects, and construct.

Soc Sci Med 2019 Jan 31. Epub 2019 Jan 31.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

In recent years a wide array of proposals for bringing intersectional perspectives into quantitative studies of health disparities have appeared, from studies of interaction, predictive discrimination, to mediation. Bauer and Scheim, in a companion set of articles, extend these proposals by developing new attribution-blind measures of perceived discrimination and using VanderWeele's 3-way decomposition to quantify its contribution to disparities through differential exposure and differential effects (sometimes called differential vulnerability or susceptibility). In this commentary, after providing an overview of causal inference interpretations with social characteristics, we provide a broad overview of old and new decomposition methods in the social sciences literature and contrast their strengths and weaknesses for studying intersectional inequalities. Read More

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http://dx.doi.org/10.1016/j.socscimed.2019.01.033DOI Listing
January 2019

Does reversal of neuromuscular block with sugammadex reduce readmission rate after surgery?

Br J Anaesth 2019 Mar 23;122(3):294-298. Epub 2019 Jan 23.

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bja.2018.12.015DOI Listing

Six-dimensional potential energy surface for NaK-NaK collisions: Gaussian process representation with correct asymptotic form.

J Chem Phys 2019 Feb;150(6):064106

Department of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada.

Constructing accurate global potential energy surfaces (PESs) describing chemically reactive molecule-molecule collisions of alkali metal dimers presents a major challenge. To be suitable for quantum scattering calculations, such PESs must represent accurately three- and four-body interactions, describe conical intersections, and have a proper asymptotic form at the long range. Here, we demonstrate that such global potentials can be obtained by Gaussian Process (GP) regression merged with the analytic asymptotic expansions at the long range. Read More

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http://dx.doi.org/10.1063/1.5082740DOI Listing
February 2019

Induction of Tier 1 HIV Neutralizing Antibodies by Envelope Trimers Incorporated into a Replication Competent Vesicular Stomatitis Virus Vector.

Viruses 2019 Feb 15;11(2). Epub 2019 Feb 15.

Division of Virology, Medical University of Innsbruck, 6020 Innsbruck, Austria.

A chimeric vesicular stomatitis virus with the glycoprotein of the lymphocytic choriomeningitis virus, VSV-GP, is a potent viral vaccine vector that overcomes several of the limitations of wild-type VSV. Here, we evaluated the potential of VSV-GP as an HIV vaccine vector. We introduced genes for different variants of the HIV-1 envelope protein Env, i. Read More

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http://dx.doi.org/10.3390/v11020159DOI Listing
February 2019

Dietary Patterns during Pregnancy Are Associated with the Risk of Gestational Diabetes Mellitus: Evidence from a Chinese Prospective Birth Cohort Study.

Nutrients 2019 Feb 15;11(2). Epub 2019 Feb 15.

Department of Social Medicine, School of Public Health, China Medical University, Shenyang 110122, China.

Dietary patterns during pregnancy have been shown to influence the development of gestational diabetes mellitus (GDM). However, evidence from Asian populations is limited and inconsistent. We conducted a prospective cohort study in China to assess the relationship between dietary patterns and GDM. Read More

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http://dx.doi.org/10.3390/nu11020405DOI Listing
February 2019

Innate Immune Modulation by GM-CSF and IL-3 in Health and Disease.

Int J Mol Sci 2019 Feb 15;20(4). Epub 2019 Feb 15.

Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131 Naples, Italy.

Granulocyte-macrophage colony-stimulating factor (GM-CSF) and inteleukin-3 (IL-3) have long been known as mediators of emergency myelopoiesis, but recent evidence has highlighted their critical role in modulating innate immune effector functions in mice and humans. This new wealth of knowledge has uncovered novel aspects of the pathogenesis of a range of disorders, including infectious, neoplastic, autoimmune, allergic and cardiovascular diseases. Consequently, GM-CSF and IL-3 are now being investigated as therapeutic targets for some of these disorders, and some phase I/II clinical trials are already showing promising results. Read More

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http://dx.doi.org/10.3390/ijms20040834DOI Listing
February 2019

Immunomagnetic-Enriched Subpopulations of Melanoma Circulating Tumour Cells (CTCs) Exhibit Distinct Transcriptome Profiles.

Cancers (Basel) 2019 Jan 30;11(2). Epub 2019 Jan 30.

School of Medical and Health Sciences, Edith Cowan University, Perth, WA 6027, Australia.

Cutaneous melanoma circulating tumour cells (CTCs) are phenotypically and molecularly heterogeneous. We profiled the gene expression of CTC subpopulations immunomagnetic-captured by targeting either the melanoma-associated marker, MCSP, or the melanoma-initiating marker, ABCB5. Firstly, the expression of a subset of melanoma genes was investigated by RT-PCR in MCSP-enriched and ABCB5-enriched CTCs isolated from a total of 59 blood draws from 39 melanoma cases. Read More

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http://dx.doi.org/10.3390/cancers11020157DOI Listing
January 2019

A Mission for Graduate Medical Education at VA.

Fed Pract 2017 Oct;34(10):12-15

was formerly chief medical resident and is a hospitalist at Beth Israel Deaconess Medical Center in Boston; was formerly chief medical resident at Boston Medical Center and is a fellow in Pulmonary & Critical Care Medicine at Boston Medical Center; was formerly chief medical resident at Boston Medical Center and is a clinical and research fellow, Pulmonary & Critical Care Medicine at Massachusetts General Hospital in Boston; was formerly chief medical resident at Brigham and Women's Hospital and is a hospitalist at Dana-Farber Cancer Institute in Boston; and is director of medical resident education at VA Boston Healthcare System; all in Massachusetts. Dr. Ganatra is an instructor of medicine, and Dr. Breu is an assistant professor of medicine, both at Harvard Medical School.

Chief medical residents from the 3 affiliate residency training programs at VA Boston Healthcare System developed a mission statement for the educational experience of all medical trainees rotating through VA medical centers. Read More

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October 2017

Development and Implementation of a Veterans' Cancer Survivorship Program.

Fed Pract 2015 Jan;32(Suppl 1):42S-48S

, and are co-directors of the Transforming and Integrating Medical and Surgical Expertise: Patient-Centered Specialty Care Education Center of Excellence at the Louis Stokes Cleveland VAMC (LSCVAMC) in Ohio. Ms. Smith is also on the clinical faculty at the Frances Payne Bolton School of Nursing, Case Western Reserve University (CWRU) and a survivorship nurse practitioner at the LSCVAMC, both in Cleveland, Ohio. Dr. Arfons is also a medical oncologist and the director of Hematology/Oncology at LSCVAMC and assistant professor at the CRWU School of Medicine. Dr. Cmolik is also a cardiothoracic surgeon and chief of surgery at LSCVAMC. is a geriatric staff psychologist at the VA Boston Healthcare System and an associate professor of psychology in the Department of Psychiatry at Harvard Medical School, both in Boston, Massachusetts. was a clinical analyst at the VA Loma Linda Healthcare System (retired). is a primary care physician and health services researcher at the Center for Health Information and Communication, Richard L. Roudebush VAMC, and the Division of General Internal Medicine, Indiana University, both in Indianapolis, Indiana.

The integration of a cancer survivorship program and coordination of care with primary care providers in community settings is essential to address veteran cancer survivors' unique needs and to meet national guidelines. Read More

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January 2015

Neuroendocrine dysregulation and the growth hormone-IGF-1 axis in anorexia nervosa.

Expert Rev Endocrinol Metab 2012 Mar;7(2):223-231

b Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital & Harvard Medical School, Boston, MA 02114, USA.

Anorexia nervosa is a common psychiatric disorder characterized by extreme, self-induced starvation and is associated with a number of medical complications, including significant loss of bone mass. Disruption of the hypothalamic-pituitary axis has been demonstrated in anorexia nervosa and contributes to both loss of established bone mass in adults and failure to accrue normal bone mass in adolescents. Anorexia nervosa is associated with the development of a state of acquired growth hormone (GH) resistance, characterized by low IGF-1 and elevated GH levels, which may be mediated in part by FGF-21. Read More

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http://dx.doi.org/10.1586/eem.12.5DOI Listing

A decision-aid tool for ICU admission triage is associated with a reduction in potentially inappropriate intensive care unit admissions.

J Crit Care 2019 Feb 4;51:77-83. Epub 2019 Feb 4.

Medical Sciences PhD program, Faculdade de Medicina FMUSP, Universidade de São Paulo, Sao Paulo, Brazil; Teaching and Research on Palliative Care Program, Hospital Sirio-Libanes, Sao Paulo, Brazil.

Purpose: Intensive care unit (ICU) admission triage occurs frequently and often involves highly subjective decisions that may lead to potentially inappropriate ICU admissions. In this study, we evaluated the effect of implementing a decision-aid tool for ICU triage on ICU admission decisions.

Methods: This was a prospective, before-after study. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.002DOI Listing
February 2019

CRISPR-Mediated Editing of the B Cell Receptor in Primary Human B Cells.

iScience 2019 Feb 1;12:369-378. Epub 2019 Feb 1.

Department of Cancer Immunology & Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Microbiology & Immunobiology, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

Vaccination approaches have generally focused on the antigen rather than the resultant antibodies generated, which differ greatly in quality and function between individuals. The ability to replace the variable regions of the native B cell receptor (BCR) heavy and light chain loci with defined recombined sequences of a preferred monoclonal antibody could enable curative adoptive cell transfer. We report CRISPR-mediated homologous recombination (HR) into the BCR of primary human B cells. Read More

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http://dx.doi.org/10.1016/j.isci.2019.01.032DOI Listing
February 2019

Mechanisms and regulation of dopamine release.

Curr Opin Neurobiol 2019 Feb 12;57:46-53. Epub 2019 Feb 12.

Department of Neurobiology, Harvard Medical School, United States. Electronic address:

Dopamine controls motor functions, motivation, and reward-related learning through G-protein coupled receptor signaling. The current working model is that upon release, dopamine diffuses to influence many target cells via wide-spread receptors. Recent studies, however, suggest that dopamine release is fast and generates small signaling hotspots. Read More

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http://dx.doi.org/10.1016/j.conb.2019.01.001DOI Listing
February 2019