1,065 results match your criteria Hantavirus Pulmonary Syndrome

Viral Pneumonias.

Radiol Clin North Am 2022 May;60(3):383-397

Department of Radiology, MSC 10 5530, 1 University of New Mexico, Albuquerque, NM 87131-0001, USA.

Viral pneumonia is usually community acquired and caused by influenza, parainfluenza, respiratory syncytial virus, human metapneumovirus, and adenovirus. Many of these infections are airway centric and chest imaging demonstrates bronchiolitis and bronchopneumonia, With the exception of adenovirus infections, the presence of lobar consolidation usually suggests bacterial coinfection. Community-acquired viral pathogens can cause more severe pneumonia in immunocompromised hosts, who are also susceptible to CMV and varicella infection. Read More

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Modeling of hantavirus cardiopulmonary syndrome.

Medwave 2022 Apr 26;22(3):e8722. Epub 2022 Apr 26.

Centro de Investigación en Neuropsicología y Neurociencias Cognitivas (CINPSI Neurocog), Facultad de Ciencias de la Salud, Universidad Católica del Maule, Talca, Chile.

Introduction: Hantavirus cardiopulmonary syndrome is an infection caused by rodents of the Bunyanvirales family towards humans. This disease in Chile is considered endemic, which has a high fatality rate. At present, some studies show the contagion between people of the Andes virus, whose locality is concentrated in Argentina and Chile. Read More

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Use of a Novel Detection Tool to Survey Orthohantaviruses in Wild-Caught Rodent Populations.

Viruses 2022 03 25;14(4). Epub 2022 Mar 25.

Center for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

Orthohantaviruses are negative-stranded RNA viruses with trisegmented genomes that can cause severe disease in humans and are carried by several host reservoirs throughout the world. Old World orthohantaviruses are primarily located throughout Europe and Asia, causing hemorrhagic fever with renal syndrome, and New World orthohantaviruses are found in North, Central, and South America, causing hantavirus cardiopulmonary syndrome (HCPS). In the United States, Sin Nombre orthohantavirus (SNV) is the primary cause of HCPS with a fatality rate of ~36%. Read More

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Hemorrhagic Fever with Renal Syndrome: Literature Review, Epidemiology, Clinical Picture and Pathogenesis.

Infect Chemother 2022 Mar;54(1):1-19

Department of Internal Medicine, Chosun University College of Medicine, Gwangju, Korea.

Hantaviruses can cause two types of infections in humans: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome. The old world hantaviruses, primarily Hantaan virus (HTNV), responsible for causing HFRS occurs endemically in Asia and Europe. a striped field mouse, is being considered as main host reservoir for HTNV. Read More

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Hantavirus Pulmonary Syndrome in a COVID-19 Patient, Argentina, 2020.

Emerg Infect Dis 2022 Apr 24;28(4):876-878. Epub 2022 Feb 24.

We describe a patient in Argentina with severe acute respiratory syndrome coronavirus 2 infection and hantavirus pulmonary syndrome (HPS). Although both coronavirus disease and HPS can be fatal when not diagnosed and treated promptly, HPS is much more lethal. This case report may contribute to improved detection of co-infections in HPS-endemic regions. Read More

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Favipiravir in the Battle with Respiratory Viruses.

Mini Rev Med Chem 2022 Feb 18. Epub 2022 Feb 18.

Department of Medical Microbiology, Medical University of Warsaw, Chalubinskiego 5 Str., 02-004 Warsaw, Poland.

Among antiviral drugs, the vast majority targets only one or two related viruses. The conventional model, one virus - one drug, significantly limits therapeutic options. Therefore, in the strategy of controlling viral infections, there is a necessity to develop compounds with pleiotropic effects. Read More

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February 2022

A Historical Perspective of Healthcare Disparity and Infectious Disease in the Native American Population.

Am J Med Sci 2022 Apr 24;363(4):288-294. Epub 2022 Jan 24.

Advocate Lutheran General Hospital, Park Ridge, IL, USA; E2Bio Life Sciences, Evanston, IL, USA. Electronic address:

The incidence and severity of COVID-19 infections have been disproportionately high in Native American populations. Native Americans are a high-risk group for COVID-19 because of a variety of healthcare disparities. Historically, these populations suffered excessively during previous epidemics in the United States (US). Read More

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Influence of Climatic Factors on Human Hantavirus Infections in Latin America and the Caribbean: A Systematic Review.

Pathogens 2021 Dec 23;11(1). Epub 2021 Dec 23.

Department of Life Sciences, The University of the West Indies, St. Augustine 999183, Trinidad and Tobago.

Background: With the current climate change crisis and its influence on infectious disease transmission there is an increased desire to understand its impact on infectious diseases globally. Hantaviruses are found worldwide, causing infectious diseases such as haemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS)/hantavirus pulmonary syndrome (HPS) in tropical regions such as Latin America and the Caribbean (LAC). These regions are inherently vulnerable to climate change impacts, infectious disease outbreaks and natural disasters. Read More

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December 2021

Case Report: Hantavirus Cardiopulmonary Syndrome Diagnostic in the Face of the COVID-19 Pandemic.

Am J Trop Med Hyg 2022 01 19;106(3):870-873. Epub 2022 Jan 19.

Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil.

Hantavirus cardiopulmonary syndrome (HCPS) is an emerging rodent-borne disease in the Americas. The most common initial symptoms of HCPS are similar to those of COVID-19 and other respiratory infections that evolve rapidly to respiratory failure, resulting from pulmonary edema and shock in about 40% of cases. We describe a fatal case of HCPS in a 24-year-old man who was hospitalized with fever, hemoconcentration, thrombocytopenia, leukocytosis, dry cough and a bilateral diffuse alveolar pulmonary infiltrate during the emergence of the COVID-19 pandemic in Brazil. Read More

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January 2022

Global Comprehensive Outlook of Hantavirus Contagion on Humans: A Review.

Infect Disord Drug Targets 2022 Jan 5. Epub 2022 Jan 5.

Department of Pharmaceutics, Gurunanak Insti- tute of Pharmaceutical Science and Technology, Kolkata, West Bengal-700110, India.

Hantaviruses are rodent viruses that have been identified as etiologic agents of 2 diseases of humans: hemorrhagic fever with renal syndrome (HFRS) and nephropathiaepidemica (NE) in the Old World and Hantavirus pulmonary syndrome (HPS) in the New World. Orthohantavirus is a genus of sin- gle-stranded, enveloped, negative-sense RNA viruses in the family Hantaviridae of the order Bunyavi- rales. The important reservoir of Hantaviruses is rodents. Read More

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January 2022

Delayed viral clearance despite high number of activated T cells during the acute phase in Argentinean patients with hantavirus pulmonary syndrome.

EBioMedicine 2022 Jan 2;75:103765. Epub 2022 Jan 2.

Laboratorio Nacional de Referencia de Hantavirus, Instituto Nacional de Enfermedades Infecciosas, Administración Nacional de Laboratorios e Institutos de Salud Dr. Carlos G. Malbrán, Av. Vélez Sarsfield 563, Buenos Aires, Argentina. Electronic address:

Background: The hallmarks of HPS are increase of vascular permeability and endothelial dysfunction. Although an exacerbated immune response is thought to be implicated in pathogenesis, clear evidence is still elusive. As orthohantaviruses are not cytopathic CD8 T cells are believed to be the central players involved in pathogenesis. Read More

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January 2022


Raúl Riquelme

Semin Respir Crit Care Med 2021 12 16;42(6):822-827. Epub 2021 Dec 16.

Puerto Montt Hospital, San Sebastian University, Puerto Montt, Chile.

Hantaviruses are tri-segmented lipid-enveloped RNA viruses belonging to the family. Human infection corresponds to a zoonosis associated with two different clinical syndromes: hemorrhagic fever with renal syndrome that occurs in Asia and Europe and hantavirus cardiopulmonary syndrome (HCPS) that occurs in the North America, Central America and South America. The major pathogenic mechanisms in HCPS include (1) direct microvascular endothelial injury leading to increased capillary permeability and the development of noncardiogenic pulmonary edema and acute respiratory distress syndrome, and (2) exaggerated host immune response leading to secondary organ damage. Read More

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December 2021

Case Report: First Confirmed Case of Coinfection of SARS-CoV-2 With .

Front Trop Dis 2021 10;2:769330. Epub 2021 Nov 10.

Department of Research in Emerging and Zoonotic Infectious Diseases, Gorgas Memorial Institute for Health Studies, Panama City, Panama.

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a major international public health concern. The World Health Organization (WHO) declared the pandemic of coronavirus disease 2019 (COVID-19) on March 11, 2020. In Panama, the first SARS-CoV-2 infection was confirmed on March 9, 2020, and the first fatal case associated to COVID-19 was reported on March 10. Read More

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November 2021

Emerging hantaviruses in Central Argentina: First case of Hantavirus Pulmonary Syndrome caused by Alto Paraguay virus, and a novel orthohantavirus in Scapteromys aquaticus rodent.

PLoS Negl Trop Dis 2021 11 17;15(11):e0009842. Epub 2021 Nov 17.

Instituto Nacional de Enfermedades Infecciosas-Administración Nacional de Laboratorios e Institutos de Salud "Dr. C. Malbrán", Buenos Aires, Argentina.

Orthohantaviruses are emerging rodent-borne pathogens that cause Hantavirus Pulmonary Syndrome in humans. They have a wide range of rodent reservoir hosts and are transmitted to humans through aerosolized viral particles generated by the excretions of infected individuals. Since the first description of HPS in Argentina, new hantaviruses have been reported throughout the country, most of which are pathogenic to humans. Read More

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November 2021

First Evidence of Akodon-Borne Orthohantavirus in Northeastern Argentina.

Ecohealth 2021 12 1;18(4):429-439. Epub 2021 Nov 1.

Instituto de Ecología, Genética y Evolución de Buenos Aires (CONICET-UBA). Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Intendente Güiraldes 2160 - Ciudad Universitaria, C1428EGA, Ciudad Autónoma de Buenos Aires, Argentina.

Orthohantaviruses (genus Orthohantavirus, family Hantaviridae) are the etiologic agents of Hantavirus Pulmonary Syndrome in the Americas. In South America, orthohantaviruses are highly diverse and are hosted by sigmodontine rodents (subfamiliy Sigmodontinae, family Cricetidae), an also diverse group of rodents. The aims of this work were to (1) identify orthohantavirus hosts and (2) to study the spatial and temporal variations in the prevalence of infection and their associations with community, environmental and individual characteristics, in different environments of Misiones province, northeastern Argentina. Read More

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December 2021

Impact of Predator Exclusion and Habitat on Seroprevalence of New World Harbored by Two Sympatric Rodents within the Interior Atlantic Forest.

Viruses 2021 09 29;13(10). Epub 2021 Sep 29.

Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

Understanding how perturbations to trophic interactions influence virus-host dynamics is essential in the face of ongoing biodiversity loss and the continued emergence of RNA viruses and their associated zoonoses. Herein, we investigated the role of predator exclusion on rodent communities and the seroprevalence of hantaviruses within the Reserva Natural del Bosque Mbaracayú (RNBM), which is a protected area of the Interior Atlantic Forest (IAF). In the IAF, two sympatric rodent reservoirs, and , harbor Jaborá and Juquitiba hantavirus (JABV, JUQV), respectively. Read More

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September 2021

Viruses Run: The Evasion Mechanisms of the Antiviral Innate Immunity by Hantavirus.

Front Microbiol 2021 30;12:759198. Epub 2021 Sep 30.

Department of Microbiology, School of Basic Medicine, Fourth Military Medical University, Xi΄an, China.

Hantavirus can cause hemorrhagic fever with renal syndrome (HFRS) in Eurasia and hantavirus pulmonary syndrome (HPS) in America, with high mortality and unknown mechanisms. Innate immunity is the host's first-line defense to bridge the acquired immunity against viral infections. However, hantavirus has evolved various strategies in both molecular and cellular aspects to evade the host's natural immune surveillance. Read More

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September 2021

Hantavirus Disease and COVID-19.

Am J Clin Pathol 2022 03;157(3):470-475

Navajo Epidemiology Center, Window Rock, AZ, USA.

Objectives: Navajo Nation is disproportionately affected by hantavirus cardiopulmonary syndrome (HCPS), a severe respiratory disease that can quickly progress to respiratory failure and cardiogenic shock. The initial signs and symptoms of HCPS are indistinguishable from coronavirus disease 2019 (COVID-19). However, this distinction is critical, as the disease course differs greatly, with most patients with COVID-19 experiencing mild to moderate illness. Read More

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Novel infection of pericytes by Andes virus enhances endothelial cell permeability.

Virus Res 2021 12 5;306:198584. Epub 2021 Oct 5.

Dept. of Microbiology and Immunology; Molecular and Cellular Biology Program; Center for Infectious Disease, Stony Brook University, Stony Brook, NY.

Andes Virus (ANDV) non-lytically infects pulmonary microvascular endothelial cells (PMECs) causing a severe capillary leak syndrome termed Hantavirus Pulmonary Syndrome (HPS). Basolaterally, PMECs are in contact with pericytes which play critical roles in regulating PMEC permeability and immune cell recruitment. We discovered that ANDV persistently infects primary human vascular pericytes for up to 9 days, and that PMEC monolayer permeability was increased by supernatants from ANDV-infected pericytes. Read More

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December 2021

Hantavirus Cardiopulmonary Syndrome and Diffuse Alveolar Hemorrhage in the Era of COVID-19.

Case Rep Infect Dis 2021 24;2021:8800500. Epub 2021 Sep 24.

Infectious Disease, Sanford USD Medical Center, Sioux Falla, SD, USA.

Hantavirus Cardiopulmonary Syndrome (HCPS) can occur after infection with Hantavirus which can occur by inhaling aerosolized rodent urine, feces, and saliva contaminated with the virus. It presents with the rapid development of pulmonary edema, respiratory failure, and cardiogenic shock with the hallmark being microvascular leakage. We report a patient with a history of alcohol abuse and recent exposure to mice and sick kittens who presented with cough with sputum production, shortness of breath, orthopnea, and new-onset lower extremity edema. Read More

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September 2021

Hantaviruses in Agricultural and Forestry Workers: Knowledge, Attitudes and Practices in Italian Physicians.

Trop Med Infect Dis 2021 Sep 20;6(3). Epub 2021 Sep 20.

Department of Medicine and Surgery, University of Parma, Via Gramsci, 14, I-43126 Parma, PR, Italy.

Hantaviruses are viral pathogens usually endemic in rodent populations. Human exposure follows inhalation of dusts contaminated with rodent excreta, and most individuals have been infected in occupational settings heavily contaminated with rodent droppings, such as agricultural and forestry. To date, knowledge, attitudes and practices of medical professionals, especially occupational physicians (OP), regarding hantavirus disease in at-risk workers have been scarcely investigated. Read More

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September 2021

Tracing Transmission of Sin Nombre Virus and Discovery of Infection in Multiple Rodent Species.

J Virol 2021 11 22;95(23):e0153421. Epub 2021 Sep 22.

Center for Global Health, Department of Internal Medicine, University of New Mexicogrid.266832.b Health Sciences Center, Albuquerque, New Mexico, USA.

Sin Nombre orthohantavirus (SNV), a negative-sense, single-stranded RNA virus that is carried and transmitted by the North American deer mouse Peromyscus maniculatus, can cause infection in humans through inhalation of aerosolized excreta from infected rodents. This infection can lead to hantavirus cardiopulmonary syndrome (HCPS), which has an ∼36% case-fatality rate. We used reverse transcriptase quantitative PCR (RT-qPCR) to confirm SNV infection in a patient and identified SNV in lung tissues in wild-caught rodents from potential sites of exposure. Read More

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November 2021

Evidence for human-to-human transmission of hantavirus: a systematic review.

J Infect Dis 2021 Sep 13. Epub 2021 Sep 13.

Department of Health Emergencies, Pan American Health Organization, Washington DC, USA.

Background: Hantavirus is known to be transmitted from rodents to humans. However, some reports from Argentina and Chile have claimed that the hantavirus strain - Andes virus (ANDV) - can cause human-to-human transmission of the disease. The aim of this systematic review was to assess the evidence for human-to-human transmission of hantavirus. Read More

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September 2021

Innate Immunity to Orthohantaviruses: Could Divergent Immune Interactions Explain Host-specific Disease Outcomes?

Alison M Kell

J Mol Biol 2022 03 4;434(6):167230. Epub 2021 Sep 4.

Department of Molecular Genetics and Microbiology, University of New Mexico, 915 Camino de Salud, Albuquerque, NM 87131, United States. Electronic address:

The genus Orthohantavirus (family Hantaviridae, order Bunyavirales) consists of numerous genetic and pathologically distinct viral species found within rodent and mammalian insectivore populations world-wide. Although reservoir hosts experience persistent asymptomatic infection, numerous rodent-borne orthohantaviruses cause severe disease when transmitted to humans, with case-fatality rates up to 40%. The first isolation of an orthohantavirus occurred in 1976 and, since then, the field has made significant progress in understanding the immune correlates of disease, viral interactions with the human innate immune response, and the immune kinetics of reservoir hosts. Read More

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Polyclonal alpaca antibodies protect against hantavirus pulmonary syndrome in a lethal Syrian hamster model.

Sci Rep 2021 08 31;11(1):17440. Epub 2021 Aug 31.

Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.

The use of antibody-based therapies for the treatment of high consequence viral pathogens has gained interest over the last fifteen years. Here, we sought to evaluate the use of unique camelid-based IgG antibodies to prevent lethal hantavirus pulmonary syndrome (HPS) in Syrian hamsters. Using purified, polyclonal IgG antibodies generated in DNA-immunized alpacas, we demonstrate that post-exposure treatments reduced viral burdens and organ-specific pathology associated with lethal HPS. Read More

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[Controversies on corticosteroid therapy in hantavirus cardiopulmonary syndrome].

Medicina (B Aires) 2021 ;81(4):617-623

Hospital de Infecciosas Francisco J. Muñiz, Buenos Aires, Argentina.

Hantavirus cardiopulmonary syndrome is an emerging zoonosis in Argentina, which has low incidence but high death rates. No specific pharmacological therapy is available and symptomatic therapy is the only current alternative. This article presents the pathogenesis of hantavirus cardiopulmonary syndrome through a review of clinical experiences in neighbor South American countries, mainly Chile, and the experience acquired at the Infectious Diseases Hospital Francisco Javier Muñiz, Buenos Aires, Argentina. Read More

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Longitudinal Assessment of Cytokine Expression and Plasminogen Activation in Hantavirus Cardiopulmonary Syndrome Reveals Immune Regulatory Dysfunction in End-Stage Disease.

Viruses 2021 08 12;13(8). Epub 2021 Aug 12.

Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.

Pathogenic New World orthohantaviruses cause hantavirus cardiopulmonary syndrome (HCPS), a severe immunopathogenic disease in humans manifested by pulmonary edema and respiratory distress, with case fatality rates approaching 40%. High levels of inflammatory mediators are present in the lungs and systemic circulation of HCPS patients. Previous studies have provided insights into the pathophysiology of HCPS. Read More

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The surface glycoproteins of hantaviruses.

Curr Opin Virol 2021 10 19;50:87-94. Epub 2021 Aug 19.

Institut Pasteur, Structural Virology Unit, and CNRS UMR 3569, Paris, France.

Hantaviruses are rodent-borne viruses distributed worldwide, transmitted through the air and with the ability to spread from person to person. They maintain a non-symptomatic persistent infection in their rodent hosts, but their spillover to humans produces a renal or pulmonary syndrome associated with high fatality rates. Hantavirus particles are lipid-enveloped and display a characteristic surface lattice built up of tetragonal spikes composed of two glycoproteins, Gn and Gc. Read More

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October 2021

Cells of the human respiratory tract support the replication of pathogenic Old World orthohantavirus Puumala.

Virol J 2021 08 17;18(1):169. Epub 2021 Aug 17.

Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120, Heidelberg, Germany.

Background: Transmission of all known pathogenic orthohantaviruses (family Hantaviridae) usually occurs via inhalation of aerosols contaminated with viral particles derived from infected rodents and organ manifestation of infections is characterized by lung and kidney involvement. Orthohantaviruses found in Eurasia cause hemorrhagic fever with renal syndrome (HFRS) and New World orthohantaviruses cause hantavirus cardiopulmonary syndrome (HCPS). However, cases of infection with Old World orthohantaviruses with severe pulmonary manifestations have also been observed. Read More

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Hantavirus infection-induced B cell activation elevates free light chains levels in circulation.

PLoS Pathog 2021 08 11;17(8):e1009843. Epub 2021 Aug 11.

University of Helsinki, Medicum, Department of Virology, Helsinki, Finland.

In humans, orthohantaviruses can cause hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS). An earlier study reported that acute Andes virus HPS caused a massive and transient elevation in the number of circulating plasmablasts with specificity towards both viral and host antigens suggestive of polyclonal B cell activation. Immunoglobulins (Igs), produced by different B cell populations, comprise heavy and light chains; however, a certain amount of free light chains (FLCs) is constantly present in serum. Read More

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