4,073 results match your criteria Hantavirus Pulmonary Syndrome


Preliminary insights into the genetics of bank vole tolerance to Puumala hantavirus in Sweden.

Ecol Evol 2018 Nov 26;8(22):11273-11292. Epub 2018 Oct 26.

CBGP, INRA, CIRAD, IRD, Montpellier SupAgro Univ. Montpellier Montpellier France.

Natural reservoirs of zoonotic pathogens generally seem to be capable of tolerating infections. Tolerance and its underlying mechanisms remain difficult to assess using experiments or wildlife surveys. High-throughput sequencing technologies give the opportunity to investigate the genetic bases of tolerance, and the variability of its mechanisms in natural populations. Read More

View Article
November 2018

High plasma resistin associates with severe acute kidney injury in Puumala hantavirus infection.

PLoS One 2018 5;13(12):e0208017. Epub 2018 Dec 5.

Tampere University Hospital, Department of Internal Medicine, Tampere, Finland.

Background: Puumala hantavirus (PUUV) infected patients typically suffer from acute kidney injury (AKI). Adipokines have inflammation modulating functions in acute diseases including AKI. We examined plasma levels of three adipokines (resistin, leptin, and adiponectin) in acute PUUV infection and their associations with disease severity. Read More

View Article
December 2018
1 Read

A new Seasonal Difference Space-Time Autoregressive Integrated Moving Average (SD-STARIMA) model and spatiotemporal trend prediction analysis for Hemorrhagic Fever with Renal Syndrome (HFRS).

PLoS One 2018 26;13(11):e0207518. Epub 2018 Nov 26.

School of Economics and Management, Hubei University of Technology, Wuhan,Hubei Province, PR China.

Hemorrhagic fever with renal syndrome (HFRS) is a naturally-occurring, fecally transmitted disease caused by a Hantavirus (HV). It is extremely damaging to human health and results in many deaths annually, especially in Hubei Province, China. One of the primary characteristics of HFRS is the spatiotemporal heterogeneity of its occurrence, with notable seasonal differences. Read More

View Article
November 2018
2 Reads

Management of Diabetic Ketoacidosis with Dengue Hemorrhagic Fever.

Cureus 2018 Sep 19;10(9):e3336. Epub 2018 Sep 19.

Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, THA.

Viral hemorrhagic fever is one of the most important emerging infectious diseases. Some viral hemorrhagic fevers include dengue, hantavirus, Ebola infection, and yellow fever. Dengue virus infection results in a wide spectrum of clinical diseases, including dengue hemorrhagic fever, characterized by the transient period of plasma leakage and hemorrhagic tendency. Read More

View Article
September 2018
6 Reads

A novel genetic lineage of Tula orthohantavirus in Altai voles (Microtus obscurus) from Turkey.

Infect Genet Evol 2018 Nov 19;67:150-158. Epub 2018 Nov 19.

Dokuz Eylul University, Faculty of Medicine, Department of Medical Microbiology, 35340 Izmir, Turkey.

Orthohantaviruses (family Hantaviridae order Bunyavirales) are emerging pathogens with a significant impact on human health. They are transmitted via aerosolized excreta of rodents which also act as reservoir hosts, constituting a unique route for dispersion. Dobrava-Belgrade and Puumala orthohantaviruses have been previously reported from Anatolia, in rodents, case reports and occasional outbreaks. Read More

View Article
November 2018
4 Reads

Protocadherin-1 is essential for cell entry by New World hantaviruses.

Nature 2018 Nov 21;563(7732):559-563. Epub 2018 Nov 21.

Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.

The zoonotic transmission of hantaviruses from their rodent hosts to humans in North and South America is associated with a severe and frequently fatal respiratory disease, hantavirus pulmonary syndrome (HPS). No specific antiviral treatments for HPS are available, and no molecular determinants of in vivo susceptibility to hantavirus infection and HPS are known. Here we identify the human asthma-associated gene protocadherin-1 (PCDH1) as an essential determinant of entry and infection in pulmonary endothelial cells by two hantaviruses that cause HPS, Andes virus (ANDV) and Sin Nombre virus (SNV). Read More

View Article
November 2018
12 Reads

Two recombinant human monoclonal antibodies that protect against lethal Andes hantavirus infection in vivo.

Sci Transl Med 2018 Nov;10(468)

Faculty of Biological Science, Department of Microbiology, Center of Biotechnology, Universidad de Concepción, 4070386 Concepción, Chile.

Andes hantavirus (ANDV) is an etiologic agent of hantavirus cardiopulmonary syndrome (HCPS), a severe disease characterized by fever, headache, and gastrointestinal symptoms that may progress to hypotension, pulmonary failure, and cardiac shock that results in a 25 to 40% case-fatality rate. Currently, there is no specific treatment or vaccine; however, several studies have shown that the generation of neutralizing antibody (Ab) responses strongly correlates with survival from HCPS in humans. In this study, we screened 27 ANDV convalescent HCPS patient sera for their capacity to bind and neutralize ANDV in vitro. Read More

View Article
November 2018
5 Reads

Case report: two confirmed cases of human Seoul virus infections in Indonesia.

BMC Infect Dis 2018 Nov 16;18(1):578. Epub 2018 Nov 16.

Universitas Airlangga, Dr. Soetomo Hospital, Surabaya, Indonesia.

Background: Seoul virus (SEOV) is a member of hantavirus family, which is transmitted to humans by Rattus rattus and Rattus norvegicus. Diagnosing SEOV infection is difficult because the clinical presentations are often undifferentiated with other viral or bacterial infections and assays to test antibodies seroconversion and RNA detection are not available in resource-limited setting like Indonesia.

Case Presentation: We report two confirmed cases of SEOV infection from Indonesia. Read More

View Article
November 2018
1 Read

Spatial heterogeneity of hemorrhagic fever with renal syndrome is driven by environmental factors and rodent community composition.

PLoS Negl Trop Dis 2018 Oct 24;12(10):e0006881. Epub 2018 Oct 24.

State Key Laboratory of Remote Sensing Science, College of Global Change and Earth System Science, Beijing Normal University, Beijing, China.

Hemorrhagic fever with renal syndrome (HFRS) is a rodent-borne disease caused mainly by two hantaviruses in China: Hantaan virus and Seoul virus. Environmental factors can significantly affect the risk of contracting hantavirus infections, primarily through their effects on rodent population dynamics and human-rodent contact. We aimed to clarify the environmental risk factors favoring rodent-to-human transmission to provide scientific evidence for developing effective HFRS prevention and control strategies. Read More

View Article
October 2018
4 Reads

Falsely positive anti-glomerular basement membrane antibodies in a patient with hantavirus induced acute kidney injury - a case report.

BMC Nephrol 2018 Oct 22;19(1):286. Epub 2018 Oct 22.

Ziekenhuisgroep Twente, Department of Nephrology, Almelo, The Netherlands.

Background: Hantavirus infection is an uncommon cause of acute renal failure with massive proteinuria. Serology tests to support a presumptive diagnosis usually take a few days. During the initial work-up, autoimmune causes including anti-glomerular basement membrane (GBM) glomerulonephritis need to be excluded, because these require urgent therapy. Read More

View Article
October 2018
7 Reads

Analysis of Transmission of Infection in Epidemics: Confined Random Walkers in Dimensions Higher Than One.

Authors:
S Sugaya V M Kenkre

Bull Math Biol 2018 Dec 12;80(12):3106-3126. Epub 2018 Oct 12.

MSC01 1130, 1, University of New Mexico, 1919 Lomas Blvd. NE, Albuquerque, NM, 87131, USA.

The process of transmission of infection in epidemics is analyzed by studying a pair of random walkers, the motion of each of which in two dimensions is confined spatially by the action of a quadratic potential centered at different locations for the two walks. The walkers are animals such as rodents in considerations of the Hantavirus epidemic, infected or susceptible. In this reaction-diffusion study, the reaction is the transmission of infection, and the confining potential represents the tendency of the animals to stay in the neighborhood of their home range centers. Read More

View Article
December 2018
2 Reads

Thailand orthohantavirus infection in patients with chronic kidney disease of unknown aetiology in Sri Lanka.

Arch Virol 2018 Oct 4. Epub 2018 Oct 4.

Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Kita-ku, Kita-15, Nishi-7, Sapporo, 060-8638, Japan.

Chronic kidney disease of unknown aetiology (CKDu) reported in Sri Lanka and other countries is a mysterious and serious disease. Recently, we reported a high seroprevalence of antibodies to a hantavirus antigen among CKDu patients in Girandurukotte, Badulla district, Sri Lanka. However, the type of hantavirus with which the residents were infected was not determined. Read More

View Article
October 2018
2 Reads

Neutrophil Activation in Acute Hemorrhagic Fever With Renal Syndrome Is Mediated by Hantavirus-Infected Microvascular Endothelial Cells.

Front Immunol 2018 18;9:2098. Epub 2018 Sep 18.

Department of Virology, Medicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS) in humans. Both diseases are considered to be immunologically mediated but the exact pathological mechanisms are still poorly understood. Neutrophils are considered the first line of defense against invading microbes but little is still known of their role in virus infections. Read More

View Article
September 2018
5 Reads

[Fulminant acute kidney injury after cholecystectomy in a 45-year-old female patient].

Internist (Berl) 2018 Sep 12. Epub 2018 Sep 12.

III. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.

A cholecystectomy was carried out on a 45-year-old female patient with fever, myalgia and right upper abdominal pain because of a suspected cholecystitis. Postoperatively acute kidney injury occurred. A comprehensive medical history taken later revealed a presumed occupational contact to rodents. Read More

View Article
September 2018
2 Reads

Development of a serosurveillance assay for detection of Necoclí virus exposure.

Arch Virol 2018 Dec 6;163(12):3291-3301. Epub 2018 Sep 6.

Grupo Centauro, Universidad de Antioquia U-de-A, Sede de Investigación Universitaria, SIU, Carrera 53 No. 61-30 Lab. 233, Medellín, Antioquia, Colombia.

Hantavirus cardiopulmonary syndrome (HPS) has gained importance in Latin America as an emerging disease, with reports of about 4000 HPS cases; however, this is probably an underestimate because of limited surveillance programs and diagnostic tools to confirm HPS. In order to address this issue and develop better serosurveillance capability, we evaluated three recombinant peptides from the Necoclí virus (NECV) nucleocapsid in antibody-capture ELISA. We cloned and expressed antigens representing the whole NECV nucleocapsid protein (NECV-rN), the immunodominant domain (NECV-rN100), and a serospecific domain (NECV-rN428), and then we compared these antigens in ELISA to detect IgG antibodies to NECV in human sera. Read More

View Article
December 2018
8 Reads

Expansion of the range of Necromys lasiurus (Lund, 1841) into open areas of the Atlantic Forest biome in Rio de Janeiro state, Brazil, and the role of the species as a host of the hantavirus.

Acta Trop 2018 Dec 24;188:195-205. Epub 2018 Aug 24.

Lab. de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Pavilhão Lauro Travassos, Instituto Oswaldo Cruz/FIOCRUZ, Brazil. Electronic address:

Necromys lasiurus is a generalist rodent that is thought to be the main reservoir of the Araraquara hantavirus, which causes Hantavirus Pulmonary Syndrome, in the Brazilian Cerrado savanna. This species occurs naturally in the open habitats of the Cerrado, Pantanal and Caatinga biomes, where it often occurs at high densities, although the distribution of the species has recently been observed expanding into the Brazilian state of Rio de Janeiro. This study aimed to map the occurrence of N. Read More

View Article
December 2018
2 Reads

Bilateral massive pneumonia as an unusual manifestation of infection.

J Postgrad Med 2018 Oct-Dec;64(4):237-239

Department of Infectious Diseases and Clinical Microbiology, Bülent Ecevit University, Faculty of Medicine, Zonguldak, Turkey.

Renal involvement due to European Puumala virus (PUUV) is frequent but pulmonary involvement is quite rare. We present here, a 24-year-old male with atypical clinical presentation of acute PUUV infection with gross pulmonary and minimal renal involvement. Severe pulmonary manifestations of PUUV infection, in this case, highlights that hantavirus infection should be considered in the differential diagnosis of atypical pneumonia. Read More

View Article
August 2018
7 Reads

Long-Term Study of a Hantavirus Reservoir Population in an Urban Protected Area, Argentina.

Ecohealth 2018 Dec 20;15(4):804-814. Epub 2018 Aug 20.

Departamento de Ecología, Genética y Evolución, Facultad de Ciencias Exactas y Naturales, Instituto de Ecología, Genética y Evolución de Buenos Aires, (IEGEBA) UBA-CONICET, Universidad de Buenos Aires, Intendente Güiraldes 2160 (Ciudad Universitaria), PB II, 4to piso, Ciudad Autónoma de Buenos Aires, Argentina.

Green spaces in urban areas can play a key role in protecting wildlife. However, the presence of wildlife in urban areas can lead to human health risks. Although the presence of the rodent species Oligoryzomys flavescens (hantavirus reservoir) has been recorded in cities of Argentina, its population dynamics in this type of habitat is still unknown. Read More

View Article
December 2018

World Health Organization Methodology to Prioritize Emerging Infectious Diseases in Need of Research and Development.

Emerg Infect Dis 2018 Sep;24(9)

The World Health Organization R&D Blueprint aims to accelerate the availability of medical technologies during epidemics by focusing on a list of prioritized emerging diseases for which medical countermeasures are insufficient or nonexistent. The prioritization process has 3 components: a Delphi process to narrow down a list of potential priority diseases, a multicriteria decision analysis to rank the short list of diseases, and a final Delphi round to arrive at a final list of 10 diseases. A group of international experts applied this process in January 2017, resulting in a list of 10 priority diseases. Read More

View Article
September 2018
12 Reads

Maripa Virus RNA Load and Antibody Response in Hantavirus Pulmonary Syndrome, French Guiana.

Emerg Infect Dis 2018 Sep;24(9):1734-1736

We report viral RNA loads and antibody responses in 6 severe human cases of Maripa virus infection (2 favorable outcomes) and monitored both measures during the 6-week course of disease in 1 nonfatal case. Further research is needed to determine prevalence of this virus and its effect on other hantaviruses. Read More

View Article
September 2018
7 Reads

[Acute myopic shift call sign of hantavirus infection].

Authors:
C Tilkin S Bonnet

Rev Med Liege 2018 Jul;73(7-8):425-427

Service d'Ophtalmologie,CHR Citadelle, Liège, Belgique.

Acute myopic shift may be the first symptom of a hantavirus infection. In Belgium, lethal infections are rare, but this illness has to be ruled out in the emergency room. The refractive shift has not clearly been explained yet. Read More

View Article

Silent Orthohantavirus Circulation Among Humans and Small Mammals from Central Minas Gerais, Brazil.

Ecohealth 2018 09 13;15(3):577-589. Epub 2018 Aug 13.

Laboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627 - Campus Pampulha, Belo Horizonte, Minas Gerais, 31270-901, Brazil.

New World orthohantaviruses are emerging RNA viruses that cause hantavirus cardiopulmonary syndrome (HCPS). These viruses are a burden to public health around the world with a lethality rate of around 60%. In South America, rodents of Sigmodontinae subfamily are the main reservoirs of orthohantaviruses. Read More

View Article
September 2018
1 Read

Hantavirus Cardiopulmonary Syndrome Due to Imported Andes Hantavirus Infection in Switzerland: A Multidisciplinary Challenge, Two Cases and a Literature Review.

Clin Infect Dis 2018 Nov;67(11):1788-1795

Bern University Hospital and University of Bern, Switzerland.

Two travellers returning from South America were diagnosed with Andes hantavirus infection, the only member of the Hantaviridae family known to be transmitted from person to person. We describe the clinical course and therapeutic and infection control measures. While both patients showed high viral load (VL) and shedding over several months, 1 patient recovered within 1 week from severe respiratory illness that required noninvasive ventilation, whereas the second patient developed severe hantavirus cardiopulmonary syndrome that required extracorporeal membrane oxygenation for 27 days. Read More

View Article
November 2018
8 Reads

Habitat, species richness and hantaviruses of sigmodontine rodents within the Interior Atlantic Forest, Paraguay.

PLoS One 2018 1;13(8):e0201307. Epub 2018 Aug 1.

Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.

Four of the nine sigmodontine tribes have species that serve as reservoirs of rodent-borne hantaviruses (RBO-HV), few have been studied in any depth. Several viruses have been associated with human cases of hantavirus pulmonary syndrome often through peridomestic exposure. Jabora (JABV) and Juquitiba (JUQV), harbored by Akodon montensis and Oligoryzomys nigripes, respectively, are endemic and sympatric in the Reserva Natural de Bosque Mbaracayú (RNBM), Paraguay, a protected area of the Interior Atlantic Forest. Read More

View Article
August 2018
4 Reads

Innate immune responses elicited by Sin Nombre virus or type I IFN agonists protect hamsters from lethal Andes virus infections.

J Gen Virol 2018 Aug 1. Epub 2018 Aug 1.

Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.

Sin Nombre virus (SNV) and Andes virus (ANDV) cause hantavirus pulmonary syndrome (HPS) in humans. Both SNV and ANDV infect Syrian hamsters, but only ANDV causes lethal disease. A co-infection study was performed to determine which virus, SNV or ANDV, would dominate the survival outcome in hamsters. Read More

View Article
August 2018
8 Reads

Small-Volume Flow Cytometry-Based Multiplex Analysis of the Activity of Small GTPases.

Methods Mol Biol 2018 ;1821:177-195

Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, USA.

Small, monomeric guanine triphosphate hydrolases (GTPases) are ubiquitous cellular integrators of signaling. A signal activates the GTPase, which then binds to an effector molecule to relay a signal inside the cell. The GTPase effector trap flow cytometry assay (G-Trap) utilizes bead-based protein immobilization and dual-color flow cytometry to rapidly and quantitatively measure GTPase activity status in cell or tissue lysates. Read More

View Article
January 2018
11 Reads

Reassortment events in the evolution of hantaviruses.

Authors:
Boris Klempa

Virus Genes 2018 Oct 25;54(5):638-646. Epub 2018 Jul 25.

Biomedical Research Center, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia.

Hantaviruses (order Bunyavirales, family Hantaviridae), known as important zoonotic human pathogens, possess the capacity to exchange genome segments via genetic reassortment due to their tri-segmented genome. Although not as frequent as in the arthropod-borne bunyaviruses, reports indicating reassortment events in the evolution of hantaviruses have been recently accumulating. The intra- and inter-lineage reassortment between closely related variants has been repeatedly reported for several hantaviruses including the rodent-borne human pathogens such as Sin Nombre virus, Puumala virus, Dobrava-Belgrade virus, or Hantaan virus as well as for the more recently recognized shrew-borne hantaviruses, Imjin and Seewis. Read More

View Article
October 2018
9 Reads

Seroprevalence of Bartonella spp., Coxiella burnetii, and Hantavirus among people who inject drugs in Rio de Janeiro, Brazil: a retrospective assessment of a biobank.

Rev Inst Med Trop Sao Paulo 2018 Jul 19;60:e31. Epub 2018 Jul 19.

Fundação Oswaldo Cruz (FIOCRUZ), Instituto Oswaldo Cruz (IOC), Laboratório de Hantaviroses e Rickettsioses, Rio de Janeiro, Rio de Janeiro, Brazil.

The increasing use of illicit drugs imposes a public health challenge worldwide. People who inject drugs (PWID) are more susceptible to health complications due to immunosuppression associated with drug use and non-hygienic self-administration of substances, contaminants, and liquids. PWID are subjected to increased risk of acquiring and transmitting different pathogens (frequently functioning as sentinel cases for (re)emerging pathogens), including those transmitted by arthropods and vertebrate reservoirs in unhealthy environments. Read More

View Article
July 2018
2 Reads

Platelet Distribution Width at First Day of Hospital Admission in Patients with Hemorrhagic Fever with Renal Syndrome Caused by Hantaan Virus May Predict Disease Severity and Critical Patients' Survival.

Dis Markers 2018 19;2018:9701619. Epub 2018 Jun 19.

Department of Infectious Diseases, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061 Shaanxi, China.

Thrombocytopenia is one of the main characteristics of hemorrhagic fever with renal syndrome (HFRS). This study aimed to evaluate the associations of platelet distribution width (PDW) with the disease severity and critical patients' survival of HFRS. The demographics, clinical data, and white blood cell and platelet parameters including PDW in 260 patients hospitalized for HFRS were analyzed. Read More

View Article
October 2018
1 Read

Species diversity concurrently dilutes and amplifies transmission in a zoonotic host-pathogen system through competing mechanisms.

Proc Natl Acad Sci U S A 2018 07 16;115(31):7979-7984. Epub 2018 Jul 16.

Population Biology, Ecology, and Evolution Program, Emory University, Atlanta, GA 30322.

In this era of unprecedented biodiversity loss and increased zoonotic disease emergence, it is imperative to understand the effects of biodiversity on zoonotic pathogen dynamics in wildlife. Whether increasing biodiversity should lead to a decrease or increase in infection prevalence, termed the dilution and amplification effects, respectively, has been hotly debated in disease ecology. Sin Nombre hantavirus, which has an ∼35% mortality rate when it spills over into humans, occurs at a lower prevalence in the reservoir host, the North American deermouse, in areas with higher small mammal diversity-a dilution effect. Read More

View Article
July 2018
2 Reads

Rats! Hantavirus: A Case Report of a Suspected Case in Eastern Tennessee.

Perm J 2018 07;22

Professor of Internal Medicine at the East Tennessee State University James H Quillen College of Medicine in Johnson City.

Introduction: Hantavirus is an RNA virus that is transmitted to humans by inhalation of aerosolized excrement from infected rodents. This case report demonstrates the value of taking a thorough social history and highlights the challenges associated with early diagnosis of this viral infection.

Case Presentation: We highlight a case of suspected hantavirus infection with subtle gastrointestinal and pulmonary symptoms that challenged the initial diagnosis. Read More

View Article
July 2018
16 Reads

Magnitude and distribution of deaths due to hantavirus in Brazil, 2007-2015.

Epidemiol Serv Saude 2018 06 28;27(2):e2017221. Epub 2018 Jun 28.

Universidade de Brasília, Faculdade de Medicina, Brasília, DF, Brasil.

Objective: to describe the magnitude and temporal and spatial distribution of hantavirus cases and deaths in Brazil between 2007 and 2015.

Methods: descriptive study with data from the Notifiable Diseases Information System (SINAN).

Results: 1,060 cases and 410 deaths were reported in the period; hantavirus lethality was 39. Read More

View Article

Prevalence of spp. and Seoul hantavirus in brown rats () in four regions in the Netherlands, 2011-2015.

Infect Ecol Epidemiol 2018 26;8(1):1490135. Epub 2018 Jun 26.

Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.

Background:   Brown rats () may carry pathogens that can be a risk for public health. Brown rats in the Netherlands were tested for the zoonotic pathogens spp. and Seoul hantavirus (SEOV), in order to obtain insight in their prevalence. Read More

View Article
June 2018
5 Reads

The English Sweating Sickness: Out of Sight, Out of Mind?

Acta Med Acad 2018 May;47(1):102-116

Department of Medical Science, Academy of Sciences and Arts of Bosnia and Herzegovina, Sarajevo, Bosnia and Herzegovina.

In this paper we aim to add additional knowledge regarding the occurrence, origin and epidemiological features of the English sweating sickness. The English sweating sickness raged in five devastating epidemics with mortality rates between 30 and 50% between 1485 and 1551 throughout England, and on one occasion also affected mainland Europe, in 1529. The Picardy sweat, generally considered as the English sweating sickness' lesser deadly successor, flared up in France in 1718 and caused 196 localized outbreaks with varying severity all over France and neighboring countries up to 1861. Read More

View Article

[Outbreak of hantavirus pulmonary syndrome in Tucumán, Argentina].

Medicina (B Aires) 2018 ;78(3):151-157

Instituto Nacional de Enfermedades Virales Humanas (INEVH) Dr. Julio I. Maiztegui - ANLIS, Pergamino, Argentina.

We describe an outbreak of hantavirus pulmonary syndrome in the Burruyacú Department, Province of Tucumán. The detection in 2016 of a case of hantavirosis affecting a 23-year-old woman, considered at that time to be the first case occurred in that province, promoted a thorough epidemiological study. The investigation allowed the retrospective detection of another case occurred one month earlier in a 5-year-old child in the same Department. Read More

View Article
January 2018
2 Reads

First molecular characterization of Dobrava-Belgrade virus found in Apodemus flavicollis in Poland.

Ann Agric Environ Med 2018 Jun 22;25(2):368-373. Epub 2018 May 22.

Biological Threats Identification and Countermeasure Centre, Military Institute of Hygiene and Epidemiology, Pulawy, Poland.

Introduction: Dobrava-Belgrade virus (DOBV) is one of the emerging pathogens which have been reported during the last decades in Europe and have attracted the attention of researchers. The course of infection among humans may have a varied course - from the completely asymptomatic to the more severe forms, such as haemorrhagic fever with renal syndrome (HFRS). DOBV is hosted and carried by rodents like Apodemus flavicollis or A. Read More

View Article

Baited vaccines: A strategy to mitigate rodent-borne viral zoonoses in humans.

Zoonoses Public Health 2018 Jun 21. Epub 2018 Jun 21.

Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.

Rodents serve as the natural reservoir and vector for a variety of pathogens, some of which are responsible for severe and life-threatening disease in humans. Despite the significant impact in humans many of these viruses, including Old and New World hantaviruses as well as Arenaviruses, most have no specific vaccine or therapeutic to treat or prevent human infection. The recent success of wildlife vaccines to mitigate rabies in animal populations offers interesting insight into the use of similar strategies for other zoonotic agents of human disease. Read More

View Article
June 2018
10 Reads

Upregulation of P2YR, Active uPA, and PAI-1 Are Essential Components of Hantavirus Cardiopulmonary Syndrome.

Front Cell Infect Microbiol 2018 23;8:169. Epub 2018 May 23.

Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, United States.

Sin Nombre virus (SNV) causes hantavirus cardiopulmonary pulmonary syndrome (HCPS) with the loss of pulmonary vascular endothelial integrity, and pulmonary edema without causing cytopathic effects on the vascular endothelium. HCPS is associated primarily with a dysregulated immune response. We previously found occult signs of hemostatic imbalance in the form of a sharp >30-100 fold increase in the expression of plasminogen activator inhibitor type 1 (PAI-1), in serial blood plasma draws of terminal stage-patients. Read More

View Article
May 2018
7 Reads

Distributional ecology of Andes hantavirus: a macroecological approach.

Int J Health Geogr 2018 06 22;17(1):22. Epub 2018 Jun 22.

Department of Ecology and Evolutionary Biology, Biodiversity Institute, University of Kansas, Lawrence, KS, 66045, USA.

Background: Hantavirus pulmonary syndrome (HPS) is an infection endemic in Chile and Argentina, caused by Andes hantavirus (ANDV). The rodent Oligoryzomys longicaudatus is suggested as the main reservoir, although several other species of Sigmodontinae are known hosts of ANDV. Here, we explore potential ANDV transmission risk to humans in southern South America, based on eco-epidemiological associations among: six rodent host species, seropositive rodents, and human HPS cases. Read More

View Article
June 2018
11 Reads

Hantaviruses and a neglected environmental determinant.

One Health 2018 Jun 2;5:27-33. Epub 2018 Jan 2.

Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.

Most human pathogenic hantaviruses cause severe hemorrhagic fevers with a high rate of fatalities, such as occurs due to the genotypes causing hantavirus cardiopulmonary syndrome carried by the New World Sigmodontinae and Neotominae rodents. An increasing number of outbreaks and the possibility of cases spreading over international borders have led to greater interest in these viruses and the environmental determinants that facilitate their transmission. Rodents, shrews, moles and bats act as reservoir hosts of hantaviruses, and within the hantavirus transmission flow, the prevalence and distribution of infection in reservoir hosts is influenced by a range of factors. Read More

View Article
June 2018
7 Reads

Natural infection of Neotropical bats with hantavirus in Brazil.

Sci Rep 2018 Jun 13;8(1):9018. Epub 2018 Jun 13.

Center for Virology Research, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Bats (Order: Chiroptera) harbor a high diversity of emerging pathogens presumably because their ability to fly and social behavior favor the maintenance, evolution, and dissemination of these pathogens. Until 2012, there was only one report of the presence of Hantavirus in bats. Historically, it was thought that these viruses were harbored primarily by rodent and insectivore small mammals. Read More

View Article
June 2018
12 Reads

Molecular epidemiology of Dobrava-Belgrade virus in Greece.

Infect Genet Evol 2018 Oct 7;64:9-12. Epub 2018 Jun 7.

Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. Electronic address:

In order to gain an insight into the genetic relatedness of the Dobrava-Belgrade virus (DOBV) in Greece, a phylogenetic analysis was performed based on all currently available DOBV sequences obtained from hospitalized cases with hemorrhagic fever with renal syndrome (HFRS). Most cases occurred in northwestern and north central part of the country. Two sequence datasets consisted of 41 S and 12 M partial DOBV RNA segment sequences were analyzed. Read More

View Article
October 2018
3.020 Impact Factor

Spatiotemporal variation of the association between climate dynamics and HFRS outbreaks in Eastern China during 2005-2016 and its geographic determinants.

PLoS Negl Trop Dis 2018 06 6;12(6):e0006554. Epub 2018 Jun 6.

Center for Disease Surveillance of PLA, Institute of Disease Control and Prevention of PLA, Beijing, China.

Background: Hemorrhagic fever with renal syndrome (HFRS) is a rodent-associated zoonosis caused by hantavirus. The HFRS was initially detected in northeast China in 1931, and since 1955 it has been detected in many regions of the country. Global climate dynamics influences HFRS spread in a complex nonlinear way. Read More

View Article

Urban Rodent Surveillance, Climatic Association, and Genomic Characterization of Seoul Virus Collected at U.S. Army Garrison, Seoul, Republic of Korea, 2006-2010.

Am J Trop Med Hyg 2018 Aug 31;99(2):470-476. Epub 2018 May 31.

Department of Microbiology, College of Medicine, Korea University, Seoul, Republic of Korea.

Rodent-borne pathogens pose a critical public health threat in urban areas. An epidemiological survey of urban rodents was conducted from 2006 to 2010 at the U.S. Read More

View Article
August 2018
7 Reads

VEGF Upregulation in Viral Infections and Its Possible Therapeutic Implications.

Int J Mol Sci 2018 Jun 1;19(6). Epub 2018 Jun 1.

Department of Microbiology, College of Medicine, Imam Abdulrahman Bin Faisal University (IAU), P.O. Box 1982, Dammam 31441, Saudi Arabia.

Several viruses are recognized as the direct or indirect causative agents of human tumors and other severe human diseases. Vascular endothelial growth factor (VEGF) is identified as a principal proangiogenic factor that enhances the production of new blood vessels from existing vascular network. Therefore, oncogenic viruses such as Kaposi's sarcoma herpesvirus (KSHV) and Epstein-Barr virus (EBV) and non-oncogenic viruses such as herpes simplex virus (HSV-1) and dengue virus, which lack their own angiogenic factors, rely on the recruitment of cellular genes for angiogenesis in tumor progression or disease pathogenesis. Read More

View Article
June 2018
11 Reads

Expression of CD206 and CD163 on intermediate CD14CD16 monocytes are increased in hemorrhagic fever with renal syndrome and are correlated with disease severity.

Virus Res 2018 07 29;253:92-102. Epub 2018 May 29.

Department of Infectious Diseases, The First Hospital of Jilin University, Changchun 130021, China. Electronic address:

Background: Hantaan virus infection causes lethal hemorrhagic fever with renal syndrome (HFRS) in humans. Little is known about how monocytes contribute to HFRS pathogenesis. In this study, we aimed to investigate changes in various monocyte subsets in HFRS patients. Read More

View Article
July 2018
3 Reads

Two Atypical Cases of Hantavirus Infections from Sri Lanka.

Case Rep Infect Dis 2018 19;2018:4069862. Epub 2018 Apr 19.

The Teaching (General) Hospital-Kandy, Kandy, Sri Lanka.

There are two categories of hantaviruses resulting in two distinct illnesses. The Old World (Asia and Europe) viruses give rise to hemorrhagic fever with renal syndrome (HFRS), and the New World (Americas) viruses cause hantavirus pulmonary syndrome (HPS). Hantavirus infections have very similar clinical pictures and epidemiology to leptospirosis. Read More

View Article
April 2018
1 Read

Proteinuria and the Clinical Course of Dobrava-Belgrade Hantavirus Infection.

Nephron Extra 2018 Jan-Apr;8(1):1-10. Epub 2018 Feb 9.

Division of Nephrology, Medical Clinic I, University of Lübeck, Lübeck, Germany.

Purpose: Human infection with Dobrava-Belgrade virus (DOBV) in Northern Germany causes a mild form of hantavirus disease predominantly characterized by acute kidney injury due to interstitial nephritis. We evaluated the largest number of DOBV-infected patients so far regarding clinical course, proteinuria, and prognostic markers.

Patients And Methods: Patients with DOBV-associated hantavirus disease admitted to the Renal Division of the University of Lübeck (Germany) between 1997 and 2012 were included in this study. Read More

View Article
February 2018
1 Read