957 results match your criteria Hantavirus Pulmonary Syndrome


Detection of New World Hantavirus Antibodies in Rodents of Eastern New Mexico.

J Wildl Dis 2019 Apr 25. Epub 2019 Apr 25.

1 Department of Biology, Eastern New Mexico University, 1500 S. Ave. K, Portales, New Mexico 88130, USA.

ABSTRACT  Hantaviruses, causal agents of the potentially lethal hantavirus pulmonary syndrome, have widely distributed rodent hosts. Using an enzyme-linked immunosorbent assay, we tested blood from 398 wild rodents captured in eastern New Mexico in 2015-17 and found 42 antibody-positive samples representing six genera. Read More

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Hemorrhagic Fever with Renal Syndrome as a Cause of Acute Diarrhea.

Am J Trop Med Hyg 2019 Mar 25. Epub 2019 Mar 25.

Department of Bio-Medical Sciences, College of Medicine, Chosun University, Gwangju, Republic of Korea.

Hemorrhagic fever with renal syndrome (HFRS) is a febrile disorder caused in Korea by the Hantaan and Seoul viruses. Its characteristic clinical manifestations include fever, hemorrhage, and renal failure, but a primary presentation with acute infectious diarrhea is rare. Owing to decreased urine output and renal function, a 54-year-old patient was transferred to our hospital from a local clinic, where he/she had been receiving treatment for diarrhea occurring more than 10 times a day. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0974DOI Listing
March 2019
2 Reads

Capillary leak-syndrome triggered by Maripa virus in French Guiana: case report and implication for pathogenesis.

BMC Infect Dis 2019 Mar 15;19(1):260. Epub 2019 Mar 15.

Service de Réanimation Polyvalente, Centre Hospitalier Andrée Rosemon de Cayenne, Avenue des Flamboyants, 6006 97306, Cayenne, BP, French Guiana.

Background: We report hereby a severe case of Hantavirus Pulmonary Syndrome" (HPS) induced by Maripa virus in French Guiana and describe the mechanism of severity of the human disease.

Case Presentation: A 47-year- old patient started presenting a prodromic period with fever, dyspnea, cough and head ache. This clinical presentation was followed by a rapid respiratory, hemodynamic and renal failure leading to admission in the ICU. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3887-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420753PMC
March 2019
8 Reads
2.613 Impact Factor

Unique Interferon Pathway Regulation by the ANDV Nucleocapsid Protein is Conferred by Phosphorylation of Serine 386.

J Virol 2019 Mar 13. Epub 2019 Mar 13.

Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY

Andes virus (ANDV) causes hantavirus pulmonary syndrome (HPS) and is the only hantavirus shown to spread person-to-person and cause highly lethal HPS-like disease in Syrian hamsters. The unique ability of ANDV N protein to inhibit IFNβ induction may contribute to its virulence and spread. Here we analyzed IFNβ regulation by ANDV N protein substituted with divergent residues from the nearly identical Maporal virus (MAPV) N protein. Read More

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http://dx.doi.org/10.1128/JVI.00338-19DOI Listing
March 2019
1 Read

Infection with New York Orthohantavirus and Associated Respiratory Failure and Multiple Cerebral Complications.

Emerg Infect Dis 2019 Jun 17;25(6). Epub 2019 Jun 17.

We report a case of infection with New York orthohantavirus in a woman who showed renal impairment and hemorrhage, complicated by hydrocephalus, in Long Island, New York, USA. Phylogenetic analysis showed that this virus was genetically similar to a New York orthohantavirus isolated in the same region during 1993. Read More

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http://dx.doi.org/10.3201/eid2506.181966DOI Listing
June 2019
1 Read

Epidemiological description, case-fatality rate, and trends of Hantavirus Pulmonary Syndrome: 9 years of surveillance in Argentina.

J Med Virol 2019 Mar 6. Epub 2019 Mar 6.

Laboratorio Nacional de Referencia para Hantavirus, Instituto Nacional de Enfermedades Infecciosas (INEI) Administración Nacional de Laboratorio e Institutos de Salud (ANLIS) "Dr. C. G. Malbrán", Ciudad Autónoma de Buenos Aires, Argentina.

Hantavirus pulmonary syndrome (HPS) is an endemic disease in Argentina, one of the most affected countries in the Americas. Andes virus (ANDV) is the main Orthohantavirus species causing HPS in Argentina. In this study, the geographical distribution, clinical presentation, and epidemiological features of HPS from all endemic regions of Argentina were analyzed. Read More

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http://dx.doi.org/10.1002/jmv.25446DOI Listing
March 2019
3 Reads

The ecological dynamics of hantavirus diseases: From environmental variability to disease prevention largely based on data from China.

PLoS Negl Trop Dis 2019 02 21;13(2):e0006901. Epub 2019 Feb 21.

Centre for Ecological and Evolutionary Synthesis (CEES), Department of Biosciences, University of Oslo, Blindern, Oslo, Norway.

Hantaviruses can cause hantavirus pulmonary syndrome (HPS) in the Americas and hemorrhagic fever with renal syndrome (HFRS) in Eurasia. In recent decades, repeated outbreaks of hantavirus disease have led to public concern and have created a global public health burden. Hantavirus spillover from natural hosts into human populations could be considered an ecological process, in which environmental forces, behavioral determinants of exposure, and dynamics at the human-animal interface affect human susceptibility and the epidemiology of the disease. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383869PMC
February 2019
3 Reads

Severity and outcome of hantavirus pulmonary syndrome marked by increased serum levels of IL-6 and intestinal fatty acid-binding protein.

J Infect Dis 2019 Jan 30. Epub 2019 Jan 30.

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Background: Hantavirus pulmonary syndrome (HPS) is caused by Andes virus (ANDV) and related hantaviruses in the Americas. Despite a fatality rate of 40%, the pathogenesis of HPS is poorly understood and factors associated with severity, fatality and survival remain elusive.

Methods: Ninety-three ANDV-infected HPS patients, out of whom 34 had a fatal outcome, were retrospectively studied. Read More

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http://dx.doi.org/10.1093/infdis/jiz005DOI Listing
January 2019
7 Reads

Orthohantaviruses belonging to three phylogroups all inhibit apoptosis in infected target cells.

Sci Rep 2019 Jan 29;9(1):834. Epub 2019 Jan 29.

Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Orthohantaviruses, previously known as hantaviruses, are zoonotic viruses that can cause hantavirus pulmonary syndrome (HPS) and hemorrhagic fever with renal syndrome (HFRS) in humans. The HPS-causing Andes virus (ANDV) and the HFRS-causing Hantaan virus (HTNV) have anti-apoptotic effects. To investigate if this represents a general feature of orthohantaviruses, we analysed the capacity of six different orthohantaviruses - belonging to three distinct phylogroups and representing both pathogenic and non-pathogenic viruses - to inhibit apoptosis in infected cells. Read More

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http://dx.doi.org/10.1038/s41598-018-37446-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351540PMC
January 2019
7 Reads

Innate and adaptive immune responses against human Puumala virus infection: immunopathogenesis and suggestions for novel treatment strategies for severe hantavirus-associated syndromes.

J Intern Med 2019 Jan 21. Epub 2019 Jan 21.

Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Two related hyperinflammatory syndromes are distinguished following infection of humans with hantaviruses: haemorrhagic fever with renal syndrome (HFRS) seen in Eurasia and hantavirus pulmonary syndrome (HPS) seen in the Americas. Fatality rates are high, up to 10% for HFRS and around 35%-40% for HPS. Puumala virus (PUUV) is the most common HFRS-causing hantavirus in Europe. Read More

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http://dx.doi.org/10.1111/joim.12876DOI Listing
January 2019
4 Reads

Two Point Mutations in Old World Hantavirus Glycoproteins Afford the Generation of Highly Infectious Recombinant Vesicular Stomatitis Virus Vectors.

MBio 2019 01 8;10(1). Epub 2019 Jan 8.

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA

Rodent-to-human transmission of hantaviruses is associated with severe disease. Currently, no FDA-approved, specific antivirals or vaccines are available, and the requirement for high biocontainment (biosafety level 3 [BSL-3]) laboratories limits hantavirus research. To study hantavirus entry in a BSL-2 laboratory, we set out to generate replication-competent, recombinant vesicular stomatitis viruses (rVSVs) bearing the Gn and Gc (Gn/Gc) entry glycoproteins. Read More

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http://mbio.asm.org/lookup/doi/10.1128/mBio.02372-18
Publisher Site
http://dx.doi.org/10.1128/mBio.02372-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325249PMC
January 2019
9 Reads

Complete Genome Sequences of Monongahela Hantavirus from Pennsylvania, USA.

Microbiol Resour Announc 2018 Sep 20;7(11). Epub 2018 Sep 20.

Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Monongahela hantavirus was first identified in deer mice and was later found responsible for hantavirus pulmonary syndrome cases in Pennsylvania and West Virginia in the United States. Here, we report the complete sequences of Monongahela virus S, M, and L genomic segments obtained from a fatal clinical case reported in 1997. Read More

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http://dx.doi.org/10.1128/MRA.00928-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256665PMC
September 2018
10 Reads

Protocadherin-1 is essential for cell entry by New World hantaviruses.

Nature 2018 11 21;563(7732):559-563. Epub 2018 Nov 21.

Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.

The zoonotic transmission of hantaviruses from their rodent hosts to humans in North and South America is associated with a severe and frequently fatal respiratory disease, hantavirus pulmonary syndrome (HPS). No specific antiviral treatments for HPS are available, and no molecular determinants of in vivo susceptibility to hantavirus infection and HPS are known. Here we identify the human asthma-associated gene protocadherin-1 (PCDH1) as an essential determinant of entry and infection in pulmonary endothelial cells by two hantaviruses that cause HPS, Andes virus (ANDV) and Sin Nombre virus (SNV). Read More

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http://dx.doi.org/10.1038/s41586-018-0702-1DOI Listing
November 2018
70 Reads

Two recombinant human monoclonal antibodies that protect against lethal Andes hantavirus infection in vivo.

Sci Transl Med 2018 11;10(468)

Faculty of Biological Science, Department of Microbiology, Center of Biotechnology, Universidad de Concepción, 4070386 Concepción, Chile.

Andes hantavirus (ANDV) is an etiologic agent of hantavirus cardiopulmonary syndrome (HCPS), a severe disease characterized by fever, headache, and gastrointestinal symptoms that may progress to hypotension, pulmonary failure, and cardiac shock that results in a 25 to 40% case-fatality rate. Currently, there is no specific treatment or vaccine; however, several studies have shown that the generation of neutralizing antibody (Ab) responses strongly correlates with survival from HCPS in humans. In this study, we screened 27 ANDV convalescent HCPS patient sera for their capacity to bind and neutralize ANDV in vitro. Read More

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http://dx.doi.org/10.1126/scitranslmed.aat6420DOI Listing
November 2018
17 Reads

Expansion of the range of Necromys lasiurus (Lund, 1841) into open areas of the Atlantic Forest biome in Rio de Janeiro state, Brazil, and the role of the species as a host of the hantavirus.

Acta Trop 2018 Dec 24;188:195-205. Epub 2018 Aug 24.

Lab. de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Pavilhão Lauro Travassos, Instituto Oswaldo Cruz/FIOCRUZ, Brazil. Electronic address:

Necromys lasiurus is a generalist rodent that is thought to be the main reservoir of the Araraquara hantavirus, which causes Hantavirus Pulmonary Syndrome, in the Brazilian Cerrado savanna. This species occurs naturally in the open habitats of the Cerrado, Pantanal and Caatinga biomes, where it often occurs at high densities, although the distribution of the species has recently been observed expanding into the Brazilian state of Rio de Janeiro. This study aimed to map the occurrence of N. Read More

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http://dx.doi.org/10.1016/j.actatropica.2018.08.026DOI Listing
December 2018
12 Reads

Maripa Virus RNA Load and Antibody Response in Hantavirus Pulmonary Syndrome, French Guiana.

Emerg Infect Dis 2018 09;24(9):1734-1736

We report viral RNA loads and antibody responses in 6 severe human cases of Maripa virus infection (2 favorable outcomes) and monitored both measures during the 6-week course of disease in 1 nonfatal case. Further research is needed to determine prevalence of this virus and its effect on other hantaviruses. Read More

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http://dx.doi.org/10.3201/eid2409.180223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106408PMC
September 2018
19 Reads

Habitat, species richness and hantaviruses of sigmodontine rodents within the Interior Atlantic Forest, Paraguay.

PLoS One 2018 1;13(8):e0201307. Epub 2018 Aug 1.

Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.

Four of the nine sigmodontine tribes have species that serve as reservoirs of rodent-borne hantaviruses (RBO-HV), few have been studied in any depth. Several viruses have been associated with human cases of hantavirus pulmonary syndrome often through peridomestic exposure. Jabora (JABV) and Juquitiba (JUQV), harbored by Akodon montensis and Oligoryzomys nigripes, respectively, are endemic and sympatric in the Reserva Natural de Bosque Mbaracayú (RNBM), Paraguay, a protected area of the Interior Atlantic Forest. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201307PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070238PMC
January 2019
14 Reads

Innate immune responses elicited by Sin Nombre virus or type I IFN agonists protect hamsters from lethal Andes virus infections.

J Gen Virol 2018 Aug 1. Epub 2018 Aug 1.

Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.

Sin Nombre virus (SNV) and Andes virus (ANDV) cause hantavirus pulmonary syndrome (HPS) in humans. Both SNV and ANDV infect Syrian hamsters, but only ANDV causes lethal disease. A co-infection study was performed to determine which virus, SNV or ANDV, would dominate the survival outcome in hamsters. Read More

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http://dx.doi.org/10.1099/jgv.0.001131DOI Listing
August 2018
18 Reads

Species diversity concurrently dilutes and amplifies transmission in a zoonotic host-pathogen system through competing mechanisms.

Proc Natl Acad Sci U S A 2018 07 16;115(31):7979-7984. Epub 2018 Jul 16.

Population Biology, Ecology, and Evolution Program, Emory University, Atlanta, GA 30322.

In this era of unprecedented biodiversity loss and increased zoonotic disease emergence, it is imperative to understand the effects of biodiversity on zoonotic pathogen dynamics in wildlife. Whether increasing biodiversity should lead to a decrease or increase in infection prevalence, termed the dilution and amplification effects, respectively, has been hotly debated in disease ecology. Sin Nombre hantavirus, which has an ∼35% mortality rate when it spills over into humans, occurs at a lower prevalence in the reservoir host, the North American deermouse, in areas with higher small mammal diversity-a dilution effect. Read More

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http://dx.doi.org/10.1073/pnas.1807106115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077700PMC
July 2018
7 Reads

Rats! Hantavirus: A Case Report of a Suspected Case in Eastern Tennessee.

Perm J 2018 07;22:17-222

Professor of Internal Medicine at the East Tennessee State University James H Quillen College of Medicine in Johnson City.

Introduction: Hantavirus is an RNA virus that is transmitted to humans by inhalation of aerosolized excrement from infected rodents. This case report demonstrates the value of taking a thorough social history and highlights the challenges associated with early diagnosis of this viral infection.

Case Presentation: We highlight a case of suspected hantavirus infection with subtle gastrointestinal and pulmonary symptoms that challenged the initial diagnosis. Read More

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http://dx.doi.org/10.7812/TPP/17-222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047851PMC
July 2018
31 Reads

[Outbreak of hantavirus pulmonary syndrome in Tucumán, Argentina].

Medicina (B Aires) 2018;78(3):151-157

Instituto Nacional de Enfermedades Virales Humanas (INEVH) Dr. Julio I. Maiztegui - ANLIS, Pergamino, Argentina.

We describe an outbreak of hantavirus pulmonary syndrome in the Burruyacú Department, Province of Tucumán. The detection in 2016 of a case of hantavirosis affecting a 23-year-old woman, considered at that time to be the first case occurred in that province, promoted a thorough epidemiological study. The investigation allowed the retrospective detection of another case occurred one month earlier in a 5-year-old child in the same Department. Read More

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February 2019
4 Reads

Upregulation of P2YR, Active uPA, and PAI-1 Are Essential Components of Hantavirus Cardiopulmonary Syndrome.

Front Cell Infect Microbiol 2018 23;8:169. Epub 2018 May 23.

Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, United States.

Sin Nombre virus (SNV) causes hantavirus cardiopulmonary pulmonary syndrome (HCPS) with the loss of pulmonary vascular endothelial integrity, and pulmonary edema without causing cytopathic effects on the vascular endothelium. HCPS is associated primarily with a dysregulated immune response. We previously found occult signs of hemostatic imbalance in the form of a sharp >30-100 fold increase in the expression of plasminogen activator inhibitor type 1 (PAI-1), in serial blood plasma draws of terminal stage-patients. Read More

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http://dx.doi.org/10.3389/fcimb.2018.00169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001748PMC
May 2018
22 Reads

Distributional ecology of Andes hantavirus: a macroecological approach.

Int J Health Geogr 2018 06 22;17(1):22. Epub 2018 Jun 22.

Department of Ecology and Evolutionary Biology, Biodiversity Institute, University of Kansas, Lawrence, KS, 66045, USA.

Background: Hantavirus pulmonary syndrome (HPS) is an infection endemic in Chile and Argentina, caused by Andes hantavirus (ANDV). The rodent Oligoryzomys longicaudatus is suggested as the main reservoir, although several other species of Sigmodontinae are known hosts of ANDV. Here, we explore potential ANDV transmission risk to humans in southern South America, based on eco-epidemiological associations among: six rodent host species, seropositive rodents, and human HPS cases. Read More

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http://dx.doi.org/10.1186/s12942-018-0142-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013855PMC
June 2018
26 Reads

Two Atypical Cases of Hantavirus Infections from Sri Lanka.

Case Rep Infect Dis 2018 19;2018:4069862. Epub 2018 Apr 19.

The Teaching (General) Hospital-Kandy, Kandy, Sri Lanka.

There are two categories of hantaviruses resulting in two distinct illnesses. The Old World (Asia and Europe) viruses give rise to hemorrhagic fever with renal syndrome (HFRS), and the New World (Americas) viruses cause hantavirus pulmonary syndrome (HPS). Hantavirus infections have very similar clinical pictures and epidemiology to leptospirosis. Read More

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http://dx.doi.org/10.1155/2018/4069862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933029PMC
April 2018
5 Reads

A Nonfatal Case of Dobrava Hantavirus Hemorrhagic Fever with Renal Syndrome Combined with Hantavirus Cardiopulmonary Syndrome.

J Glob Infect Dis 2018 Jan-Mar;10(1):22-25

Institute of Public Health, Prishtina, Kosovo.

Among hantaviruses (HTNV), 22 are known as pathogenic for humans. HTNV can cause two clinical entities: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome or hantavirus cardiopulmonary syndrome (HCPS). In most countries of Eastern Europe as well as in Kosovo, HTNV infection is presented mainly as HFRS. Read More

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http://dx.doi.org/10.4103/jgid.jgid_12_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850759PMC
March 2018
16 Reads

Identification of tell-tale patterns in the 3' non-coding region of hantaviruses that distinguish HCPS-causing hantaviruses from HFRS-causing hantaviruses.

Emerg Microbes Infect 2018 03 21;7(1):32. Epub 2018 Mar 21.

Sri Sakthi Amma Institute of Biomedical Research, Sri Narayani Hospital and Research Centre, Sripuram, Vellore, 632055, Tamil Nadu, India.

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http://dx.doi.org/10.1038/s41426-018-0027-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861111PMC
March 2018
3 Reads

Hantavirus induced cardiopulmonary syndrome: A public health concern.

J Med Virol 2018 06 15;90(6):1003-1009. Epub 2018 Mar 15.

Saint Joseph's Hospital Medical Center, Phoenix, Arizona.

Hantavirus cardiopulmonary syndrome is characterized by pulmonary capillary leakage and alveolar flooding, resulting in 50% mortality due to fulminant hypoxic respiratory failure. In addition, depression of cardiac function ensues, which complicates the picture with cardiogenic shock. Early diagnosis and appropriate use of extracorporeal membrane oxygenation (ECMO) are amongst the lifesaving interventions in this fatal illness. Read More

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http://dx.doi.org/10.1002/jmv.25054DOI Listing
June 2018
7 Reads
2.350 Impact Factor

Severe hantavirus disease in children.

J Clin Virol 2018 04 31;101:66-68. Epub 2018 Jan 31.

Institute of Medical Virology, Helmut-Ruska-Haus, Charité School of Medicine, Berlin, Germany. Electronic address:

Background: Very recently, a novel European hantavirus, Sochi virus, has been discovered which causes severe courses of hantavirus disease with a case fatality rate of about 15 percent.

Objectives: We aimed to study to which extent and with which clinical severity children were affected by Sochi virus infection.

Study Design: Sochi virus infection of patients was confirmed by molecular, serological, and epizoonotic studies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13866532183003
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http://dx.doi.org/10.1016/j.jcv.2018.01.018DOI Listing
April 2018
12 Reads

A rare cause of acute pancreatitis: Hantavirus infection.

Acta Gastroenterol Belg 2017 Jan-Mar;80(1):59-61

Hantaviruses cause potentially fatal two different systemic infectious diseases in humans named as hemorrhagic fever with renal syndrome (HFRS) and Hantavirus pulmonary syndrome. The clinical features of HFRS are hemorrhage, fever, thrombocytopenia and acute renal insufficiency frequently observed. HFRS shows distinctive clinical manifestations throughout from acute influenza-like febrile illness to shock. Read More

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March 2018
5 Reads

Population-based seroprevalence of Puumala hantavirus in Finland: smoking as a risk factor.

Epidemiol Infect 2018 02 9;146(3):367-371. Epub 2018 Jan 9.

Department of Health Security,National Institute for Health and Welfare,FI-00271 Helsinki,Finland.

Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome in humans, that is an endemic disease in Finland. We estimated the seroprevalence of PUUV in Finland and explored risk factors and disease associations by using unique survey data with health register linkage. A total of 2000 sera from a nationwide health survey from 2011, representative of the adult population, were screened for PUUV IgG by immunofluorescence assay. Read More

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https://www.cambridge.org/core/product/identifier/S095026881
Publisher Site
http://dx.doi.org/10.1017/S0950268817002904DOI Listing
February 2018
9 Reads

A damped precipitation-driven, bottom-up model for deer mouse population abundance in the northwestern United States.

Ecol Evol 2017 12 15;7(24):11113-11123. Epub 2017 Nov 15.

Montana Tech of the University of MontanaButteMTUSA.

Small-mammal population densities can be regulated by bottom-up (food availability) and top-down (predation) forces. In 1993, an El Niño Southern Oscillation event was followed by a cluster of human hantavirus with pulmonary syndrome in the southwestern United States. An upward trophic cascade hypothesis was proposed as an explanation for the outbreak: Increased plant productivity as a consequence of El Niño precipitations led to an unusual increase in distribution and abundance of deer mice (; reservoir host of Sin Nombre virus). Read More

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http://dx.doi.org/10.1002/ece3.3598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743491PMC
December 2017
5 Reads

The Impact of Global Environmental Changes on Infectious Disease Emergence with a Focus on Risks for Brazil.

ILAR J 2017 12;58(3):393-400

Alessandra Nava, PhD, is a researcher at FIOCRUZ ILMD in Manaus, Brazil. Dr. Nava is part of Cnpq Research Group Ecology of Transmissible Diseases in Amazon, serves on the executive board of the International Association for Ecology and Health, and IUCN Peccaries specialist group. Juliana Suieko Shimabukuro, MSc, is a PhD student at University of São Paulo in São Paulo, Brazil. Aleksei A. Chmura, BSc, is a program coordinator at EcoHealth Alliance in New York, NY, USA and a PhD student at Kingston University in London, United Kingdom. Sérgio Luiz Bessa Luz, PhD, is Director at Instituto Lêonidas e Maria Deane FIOCRUZ Amazônia in Amazonas, Brazil.

Environmental changes have a huge impact on the emergence and reemergence of certain infectious diseases, mostly in countries with high biodiversity and serious unresolved environmental, social, and economic issues. This article summarizes the most important findings with special attention to Brazil and diseases of present public health importance in the country such as Chikungunya, dengue fever, yellow fever, Zika, hantavirus pulmonary syndrome, leptospirosis, leishmaniasis, and Chagas disease. An extensive literature review revealed a relationship between infectious diseases outbreaks and climate change events (El Niño, La Niña, heatwaves, droughts, floods, increased temperature, higher rainfall, and others) or environmental changes (habitat fragmentation, deforestation, urbanization, bushmeat consumption, and others). Read More

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https://academic.oup.com/ilarjournal/article/58/3/393/474572
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http://dx.doi.org/10.1093/ilar/ilx034DOI Listing
December 2017
10 Reads

Space Use and Social Mating System of the Hantavirus Host, Oligoryzomys longicaudatus.

Ecohealth 2018 03 1;15(1):96-108. Epub 2017 Dec 1.

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Avda. Rivadavia 1917, CP C1033AAJ, Ciudad Autónoma de Buenos Aires, Argentina.

The long-tailed mouse, Oligoryzomys longicaudatus (Cricetidae: Sigmodontinae), is the major host of Andes hantavirus, the etiological agent of hantavirus pulmonary syndrome in the south of Argentina and Chile. Studying the ecology of this species is necessary to understand how Andes hantavirus is maintained in nature. In this study, we examine the home range size and intra- and intersexual overlap degree of male and female O. Read More

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http://dx.doi.org/10.1007/s10393-017-1301-6DOI Listing
March 2018
7 Reads

A lethal disease model for New World hantaviruses using immunosuppressed Syrian hamsters.

PLoS Negl Trop Dis 2017 Oct 27;11(10):e0006042. Epub 2017 Oct 27.

KU Leuven-University of Leuven, Department of Microbiology and Immunology, Laboratory of Clinical Virology, Zoonotic Infectious Diseases unit, Leuven, Belgium.

Background: Hantavirus, the hemorrhagic causative agent of two clinical diseases, is found worldwide with variation in severity, incidence and mortality. The most lethal hantaviruses are found on the American continent where the most prevalent viruses like Andes virus and Sin Nombre virus are known to cause hantavirus pulmonary syndrome. New World hantavirus infection of immunocompetent hamsters results in an asymptomatic infection except for Andes virus and Maporal virus; the only hantaviruses causing a lethal disease in immunocompetent Syrian hamsters mimicking hantavirus pulmonary syndrome in humans. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678717PMC
October 2017
58 Reads

Hantavirus and tuberculosis co-infection in an Indian child.

Indian J Med Microbiol 2017 Jul-Sep;35(3):426-428

Department of Pediatrics, Pediatric Intensive Care Unit, Balabhai Nanavati Hospital, Mumbai, Maharashtra, India.

Hantaviruses are a group of antigenically distinct viruses carried out in rodents and insectivores. Humans are accidental hosts and get infected by aerosols generated from contaminated urine, faeces and saliva of infected rodents. Hantaviruses are identified as aetiological agents of two human diseases, haemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Read More

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http://dx.doi.org/10.4103/ijmm.IJMM_16_161DOI Listing
June 2018
17 Reads

Risk of Venous Thromboembolism Following Hemorrhagic Fever With Renal Syndrome: A Self-controlled Case Series Study.

Clin Infect Dis 2018 Jan;66(2):268-273

Unit of Infectious Diseases, Department of Clinical Microbiology, Umeå University, Sweden.

Background: Bleeding is associated with viral hemorrhagic fevers; however, thromboembolic complications have received less attention. Hemorrhagic fever with renal syndrome (HFRS) is a mild viral hemorrhagic fever caused by Puumala hantavirus. We previously identified HFRS as a risk factor for myocardial infarction and stroke, but the risk for venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is unknown. Read More

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http://dx.doi.org/10.1093/cid/cix777DOI Listing
January 2018
15 Reads

Targeted inhibition of hantavirus replication and intracranial pathogenesis by a chimeric protein-delivered siRNA.

Antiviral Res 2017 Nov 7;147:107-115. Epub 2017 Oct 7.

Department of Immunology, Fourth Military Medical University, Xi'an, 710032, China. Electronic address:

Hantavirus (HV) infection, which underlies hantavirus hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome, remains to be a severe clinical challenge. Here, we synthesized small interfering RNAs (siRNAs) that target the encoding sequences of HV strain 76-118, and validated their inhibitory role in virus replication in HV-infected monkey kidney Vero E6 cells. A chimeric protein, 3G1-Cκ-tP, consisting of a single-chain antibody fragment (3G1) against the HV surface envelop glycoprotein, the constant region of human immunoglobulin κ chain (Cκ), and truncated protamine (amino acids 8-29, tP), was further generated. Read More

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http://dx.doi.org/10.1016/j.antiviral.2017.10.005DOI Listing
November 2017
44 Reads

Epidemic hemorrhagic fever complicated with late pregnancy: A case report.

Medicine (Baltimore) 2017 Oct;96(40):e8137

aDepartment of Shandong University School of Medicine, Jinan bDepartment of Respiratory Disease (Taishan Scholar Position), Binzhou Medical University Hospital, Binzhou, China.

Rationale: Hantaviruses cause two forms of diseases in humans, namely hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome. Hantavirus infections can occur in pregnant women, and could influence the maternal and fetal outcomes, although this is a rare finding, even in endemic areas.

Patient Concerns: In this report, we describe anunusual case involving a pregnant woman with HFRS who was in a state of shock. Read More

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http://dx.doi.org/10.1097/MD.0000000000008137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737999PMC
October 2017
19 Reads

EVALUATING THE IMPACTS OF COINFECTION ON IMMUNE SYSTEM FUNCTION OF THE DEER MOUSE ( PEROMYSCUS MANICULATUS) USING SIN NOMBRE VIRUS AND BARTONELLA AS MODEL PATHOGEN SYSTEMS.

J Wildl Dis 2018 01 4;54(1):66-75. Epub 2017 Oct 4.

1   Department of Biology, Fort Lewis College, 1000 Rim Drive, Durango, Colorado 81301, USA.

:  Simultaneous infections with multiple pathogens can alter the function of the host's immune system, often resulting in additive or synergistic morbidity. We examined how coinfection with the common pathogens Sin Nombre virus (SNV) and Bartonella sp. affected aspects of the adaptive and innate immune responses of wild deer mice ( Peromyscus maniculatus). Read More

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http://dx.doi.org/10.7589/2017-01-015DOI Listing
January 2018
11 Reads

Hantavirus Pulmonary Syndrome Caused by Maripa Virus in French Guiana, 2008-2016.

Emerg Infect Dis 2017 10;23(10):1722-1725

We report 5 human cases of hantavirus pulmonary syndrome found during surveillance in French Guiana in 2008-2016; of the 5 patients, 4 died. This pathogen should continue to be monitored in humans and rodents in effort to reduce the occurrence of these lethal infections in humans stemming from ecosystem disturbances. Read More

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http://dx.doi.org/10.3201/eid2310.170842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621545PMC
October 2017
24 Reads

A neuropathic pain syndrome associated with hantavirus infection.

J Neurovirol 2017 12 11;23(6):919-921. Epub 2017 Sep 11.

Division of Neurology, Department of Medicine, Neuroscience and Mental Health Institute, University of Alberta, 7-132A Clinical Sciences Building, 11350-83 Ave, Edmonton, Alberta, T6G 2G3, Canada.

Hantaviruses are a group of single-stranded RNA viruses of the Bunyaviridae family. "New World" hantaviruses cause hantavirus cardiopulmonary syndrome (HCPS) in North America. HCPS carries with it significant mortality and those patients who survive the disease are often left with substantial morbidity. Read More

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http://dx.doi.org/10.1007/s13365-017-0576-2DOI Listing
December 2017
10 Reads

High-resolution computed tomography findings in hantavirus pulmonary syndrome.

Authors:
Felipe von Ranke

Radiol Bras 2017 Jul-Aug;50(4):VII-VIII

Assistant Professor of Radiology at the Universidade Federal Fluminense (UFF), Niterói, RJ, Radiologist and Medical Coordinator at Dimagem - Diagnóstico por Imagem, Nova Iguaçu, RJ, Brazil. E-mail:

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http://dx.doi.org/10.1590/0100-3984.2017.50.4e2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586527PMC
September 2017
8 Reads

Structural Transitions of the Conserved and Metastable Hantaviral Glycoprotein Envelope.

J Virol 2017 11 13;91(21). Epub 2017 Oct 13.

Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Hantaviruses are zoonotic pathogens that cause severe hemorrhagic fever and pulmonary syndrome. The outer membrane of the hantavirus envelope displays a lattice of two glycoproteins, Gn and Gc, which orchestrate host cell recognition and entry. Here, we describe the crystal structure of the Gn glycoprotein ectodomain from the Asiatic Hantaan virus (HTNV), the most prevalent pathogenic hantavirus. Read More

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http://dx.doi.org/10.1128/JVI.00378-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640846PMC
November 2017
11 Reads

Climate change and sugarcane expansion increase Hantavirus infection risk.

PLoS Negl Trop Dis 2017 Jul 20;11(7):e0005705. Epub 2017 Jul 20.

Department of Ecology, Bioscience Institute, University of São Paulo, São Paulo, São Paulo, Brazil.

Hantavirus Cardiopulmonary Syndrome (HCPS) is a disease caused by Hantavirus, which is highly virulent for humans. High temperatures and conversion of native vegetation to agriculture, particularly sugarcane cultivation can alter abundance of rodent generalist species that serve as the principal reservoir host for HCPS, but our understanding of the compound effects of land use and climate on HCPS incidence remains limited, particularly in tropical regions. Here we rely on a Bayesian model to fill this research gap and to predict the effects of sugarcane expansion and expected changes in temperature on Hantavirus infection risk in the state of São Paulo, Brazil. Read More

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http://dx.doi.org/10.1371/journal.pntd.0005705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519001PMC
July 2017
12 Reads

A Fatal Hantavirus Pulmonary Syndrome Misdiagnosed as Dengue: An Investigation into the First Reported Case in Rio de Janeiro State, Brazil.

Am J Trop Med Hyg 2017 Jul;97(1):125-129

Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brasil.

We report the results of an investigation into a fatal case of hantavirus pulmonary syndrome (HPS) in Rio de Janeiro State, Brazil, where the disease had not been reported previous to 2015. Following the notification of an HPS case, serum samples were collected from the household members and work contacts of the HPS patient and tested for antibody to hantaviruses. Seroprevalence of 22% (10/45) was indicated for hantavirus out of 45 human samples tested. Read More

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http://dx.doi.org/10.4269/ajtmh.16-0845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508898PMC
July 2017
66 Reads

Serum levels of interleukin-6 are linked to the severity of the disease caused by Andes Virus.

PLoS Negl Trop Dis 2017 Jul 14;11(7):e0005757. Epub 2017 Jul 14.

Laboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia (IMII), Departamento de Enfermedades Infecciosas e Inmunología Pediátrica, División de Pediatría, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Andes virus (ANDV) is the etiological agent of hantavirus cardiopulmonary syndrome in Chile. In this study, we evaluated the profile of the pro-inflammatory cytokines IL-1β, IL-12p70, IL-21, TNF-α, IFN-γ, IL-10 and IL-6 in serum samples of ANDV-infected patients at the time of hospitalization. The mean levels of circulating cytokines were determined by a Bead-Based Multiplex assay coupled with Luminex detection technology, in order to compare 43 serum samples of healthy controls and 43 samples of ANDV-infected patients that had been categorized according to the severity of disease. Read More

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http://dx.doi.org/10.1371/journal.pntd.0005757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529019PMC
July 2017
21 Reads

High-resolution computed tomography findings in eight patients with hantavirus pulmonary syndrome.

Radiol Bras 2017 May-Jun;50(3):148-153

MD, PhD, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.

Objective: The purpose of this study was to describe the high-resolution computed tomography (HRCT) findings in patients with hantavirus pulmonary syndrome (HPS).

Materials And Methods: We retrospectively reviewed HRCT findings from eight cases of HPS. All patients were men, aged 19-70 (mean, 41. Read More

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http://dx.doi.org/10.1590/0100-3984.2016.0093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487228PMC
July 2017
34 Reads