1,024 results match your criteria Hantavirus Pulmonary Syndrome


Two Atypical Cases of Hantavirus Infection: Experience from a Tertiary Care Unit in Sri Lanka.

Case Rep Infect Dis 2021 21;2021:5555613. Epub 2021 Apr 21.

National Hospital-Kandy, Kandy, Sri Lanka.

Hantaviruses are a large family of enveloped viruses with two medically important families Cricetidae and Muridae which are known to cause rodent-borne diseases worldwide. Some strains cause clinical syndromes with multiorgan involvement in humans such as hantavirus haemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), which is also known as hantavirus pulmonary syndrome. Clinical differentiation of this infection from other endemic infections in Sri Lanka such as leptospirosis and rickettsial infections is extremely difficult due to overlapping clinical and epidemiologic features such as exposure to rodents and farming. Read More

View Article and Full-Text PDF

Expanded distribution of orthohantavirus Pergamino genotype: First record in Entre Rios province, Argentina.

Rev Argent Microbiol 2021 Apr 19. Epub 2021 Apr 19.

Instituto Nacional de Enfermedades Infecciosas, Administración Nacional de Laboratorios e Institutos de Salud Dr. Carlos G. Malbrán, Buenos Aires, Argentina.

Hantavirus Pulmonary Syndrome (HPS) is an emerging infectious disease of the Americas. Eight native rodent species have been identified as HPS virus reservoirs in Argentina. The aim of this work was to detect the orthohantavirus genotypes present in a rodent community that inhabits a zone where a fatal HPS case occurred within an endemic locality of Central Argentina. Read More

View Article and Full-Text PDF

Targeted high volume hemofiltration could avoid extracorporeal membrane oxygenation in some patients with severe Hantavirus cardiopulmonary syndrome.

J Med Virol 2021 Mar 12. Epub 2021 Mar 12.

Departamento de Paciente Crítico, Clínica Alemana de Santiago, Santiago, Chile.

Background: Hantavirus cardiopulmonary syndrome (HCPS) has a high lethality. Severe cases may be rescued by venoarterial extracorporeal membrane oxygenation (VA ECMO), alongside substantial complications. High volume hemofiltration (HVHF) is a depurative technique that provides homeostatic balance allowing hemodynamic stabilization in some critically ill patients. Read More

View Article and Full-Text PDF

Intersecting Paths of Emerging and Reemerging Infectious Diseases.

Emerg Infect Dis 2021 May 11;27(5):1517-1519. Epub 2021 Mar 11.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shares common clinicopathologic features with other severe pulmonary illnesses. Hantavirus pulmonary syndrome was diagnosed in 2 patients in Arizona, USA, suspected of dying from infection with SARS-CoV-2. Differential diagnoses and possible co-infections should be considered for cases of respiratory distress during the SARS-CoV-2 pandemic. Read More

View Article and Full-Text PDF

Occupations at risk of contracting zoonoses of public health significance in Québec.

Can Commun Dis Rep 2021 Jan 29;47(1):47-58. Epub 2021 Jan 29.

Biological Risks and Occupational Health Division, Institut national de santé publique du Québec, Québec, QC.

Introduction: Climate change plays an important role in the geographic spread of zoonotic diseases. Knowing which populations are at risk of contracting these diseases is critical to informing public health policies and practices. In Québec, 14 zoonoses have been identified as important for public health to guide the climate change adaptation efforts of decision-makers and researchers. Read More

View Article and Full-Text PDF
January 2021

The 1993 Hantavirus Pulmonary Syndrome Outbreak and Lessons for Today.

Authors:
Matthew Borgman

Med J (Ft Sam Houst Tex) 2021 Jan-Mar(PB 8-21-01/02/03):22-27

While grappling with the implications of the current COVID-19 pandemic, we have perhaps overlooked recent history dealing with previous outbreaks. In the spring of 1993, America was presented with an outbreak of Hantavirus Pulmonary Syndrome caused by the Sin Nombre virus. This article recounts the investigation into this disease and discusses the spectrum of issues that medical communities must face as it deals with a mysterious outbreak. Read More

View Article and Full-Text PDF

Differential pathogenesis between Andes virus strains CHI-7913 and Chile-9717869in Syrian Hamsters.

J Virol 2021 Feb 24. Epub 2021 Feb 24.

Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada

Hantavirus cardiopulmonary syndrome (HCPS) is a severe respiratory disease caused by orthohantaviruses in the Americas with a fatality rate as high as 35%. In South America, Andes orthohantavirus (, ANDV) is a major cause of HCPS, particularly in Chile and Argentina, where thousands of cases have been reported since the virus was discovered. Two strains of ANDV that are classically used for experimental studies of the virus are Chile-9717869, isolated from the natural reservoir, the long-tailed pygmy rice rat, and CHI-7913, an isolate from a lethal human case of HCPS. Read More

View Article and Full-Text PDF
February 2021

Puumala Virus Infection in Family, Switzerland.

Emerg Infect Dis 2021 Feb;27(2):658-660

We report 3 cases of Puumala virus infection in a family in Switzerland in January 2019. Clinical manifestations of the infection ranged from mild influenza-like illness to fatal disease. This cluster illustrates the wide range of clinical manifestations of Old World hantavirus infections and the challenge of diagnosing travel-related hemorrhagic fevers. Read More

View Article and Full-Text PDF
February 2021

"Super-Spreaders" and Person-to-Person Transmission of Andes Virus in Argentina.

N Engl J Med 2020 12;383(23):2230-2241

From Laboratorio Nacional de Referencia de Hantavirus (V.P.M., D.O.A., C.M.B., A.A.I., R.M.C., N.P.) and Plataforma Genomica (B.L., D.C., J.C.), Instituto Nacional de Enfermedades Infecciosas, and Unidad Operativa Centro de Contención Biológica (A.E.), Administración Nacional de Laboratorios e Institutos de Salud Dr. Carlos G. Malbrán (C.P.), Secretaría de Gobierno de Salud (M.I.B., M.K., A.R.), Área Programática Esquel (J.D., E.B.), and Hospital Zonal de Esquel (L.L., C.A., C.P.O., E.L.), Ministerio de Salud de Chubut, Esquel, and Argentina Ministerio de Salud de Chubut, Rawson (T.S.), Chubut, and Hospital Zonal de Bariloche Dr. Ramón Carrillo, Ministerio de Salud de Río Negro, San Carlos de Bariloche, Río Negro (F.P.) - all in Argentina; the Center for Genome Sciences, U.S. Army Medical Research Institute of Infectious Diseases (N.D.P., U.P.-S., P.A.L., E.R.N., J.A.C., C.B.P., J.R.K., M.S.-L., G.P.), and the Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health (H.S., B.D.-K., J.H.K.), Fort Detrick, Frederick, MD; and the College of Public Health (C.B.P.) and Department of Pathology and Microbiology (M.S.-L.), University of Nebraska Medical Center, Omaha.

Background: From November 2018 through February 2019, person-to-person transmission of Andes virus (ANDV) hantavirus pulmonary syndrome occurred in Chubut Province, Argentina, and resulted in 34 confirmed infections and 11 deaths. Understanding the genomic, epidemiologic, and clinical characteristics of person-to-person transmission of ANDV is crucial to designing effective interventions.

Methods: Clinical and epidemiologic information was obtained by means of patient report and from public health centers. Read More

View Article and Full-Text PDF
December 2020

Hantavirus pulmonary syndrome outbreaks associated with climate variability in Northwestern Argentina, 1997-2017.

PLoS Negl Trop Dis 2020 11 30;14(11):e0008786. Epub 2020 Nov 30.

Instituto Nacional de Enfermedades Infecciosas (INEI), Administración Nacional de Laboratorios e Institutos de Salud (ANLIS) "Dr. C. G. Malbrán", Buenos Aires, Argentina.

Background: Rodent-borne hantaviruses (genus Orthohantavirus) are the etiologic agents causing two human diseases: hemorrhagic fever with renal syndrome (HFRS) in Euroasia; and hantavirus pulmonary syndrome (HPS) in North and South America. In South America fatality rates of HPS can reach up to 35%-50%. The transmission of pathogenic hantaviruses to humans occurs mainly via inhalation of aerosolized excreta from infected rodents. Read More

View Article and Full-Text PDF
November 2020

Hantavirus Infection Is Inhibited by Griffithsin in Cell Culture.

Front Cell Infect Microbiol 2020 4;10:561502. Epub 2020 Nov 4.

Division of High Consequence Pathogens and Pathology, Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, United States.

Andes virus (ANDV) and Sin Nombre virus (SNV), highly pathogenic hantaviruses, cause hantavirus pulmonary syndrome in the Americas. Currently no therapeutics are approved for use against these infections. Griffithsin (GRFT) is a high-mannose oligosaccharide-binding lectin currently being evaluated in phase I clinical trials as a topical microbicide for the prevention of human immunodeficiency virus (HIV-1) infection (ClinicalTrials. Read More

View Article and Full-Text PDF
December 2020

Cryofixation of Inactivated Hantavirus-Infected Cells as a Method for Obtaining High-Quality Ultrastructural Preservation for Electron Microscopic Studies.

Front Cell Infect Microbiol 2020 6;10:580339. Epub 2020 Nov 6.

Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, United States.

Hantaviruses rewire the host cell and induce extensive membrane rearrangements for their replication and the morphogenesis of the virion. Transmission electron microscopy (TEM) is a powerful technique for imaging these pathological membrane changes especially when combined with large volume electron tomography. Excellent preservation of membrane structure can be obtained when chemical fixation is combined with cryofixation via high pressure freezing making the samples amenable to serial-section tomographic reconstruction. Read More

View Article and Full-Text PDF
November 2020

Autochthonous Ratborne Seoul Virus Infection in Woman with Acute Kidney Injury.

Emerg Infect Dis 2020 12;26(12):3096-3099

Outside Asia, Seoul virus (SEOV) is an underestimated pathogen. In Germany, autochthonous SEOV-associated hantavirus disease has not been unequivocally diagnosed. We found clinical and molecular evidence for SEOV infection in a young woman; her pet rat was the source of infection. Read More

View Article and Full-Text PDF
December 2020

Hantavirus Cardiopulmonary Syndrome in Canada.

Emerg Infect Dis 2020 12;26(12):3020-3024

Hantavirus cardiopulmonary syndrome (HCPS) is a severe respiratory disease caused by Sin Nombre virus in North America (SNV). As of January 1, 2020, SNV has caused 143 laboratory-confirmed cases of HCPS in Canada. We review critical aspects of SNV virus epidemiology and the ecology, biology, and genetics of HCPS in Canada. Read More

View Article and Full-Text PDF
December 2020

Hantavirus Infections-Treatment and Prevention.

Curr Treat Options Infect Dis 2020 Oct 29:1-12. Epub 2020 Oct 29.

Department of Virology, National Hospital Kandy, Kandy, Sri Lanka.

Purpose Of Review: Hantavirus infection is an emerging zoonosis and there are two main clinical presentations, hemorrhagic fever with renal syndrome (HFRS) and Hantavirus pulmonary syndrome (HPS). Although Hantavirus infections have a worldwide distribution with a high mortality rate, a safe and effective vaccine or an antiviral drug against the Hantavirus disease is yet to be available. This review summarizes all the efforts undertaken to develop medical countermeasures in vitro, in vivo, and human clinical trials against Hantavirus infections. Read More

View Article and Full-Text PDF
October 2020

Orthohantaviruses, Emerging Zoonotic Pathogens.

Pathogens 2020 Sep 22;9(9). Epub 2020 Sep 22.

Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, USA.

Orthohantaviruses give rise to the emerging infections such as of hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) in Eurasia and the Americas, respectively. In this review we will provide a comprehensive analysis of orthohantaviruses distribution and circulation in Eurasia and address the genetic diversity and evolution of Puumala orthohantavirus (PUUV), which causes HFRS in this region. Current data indicate that the geographical location and migration of the natural hosts can lead to the orthohantaviruses genetic diversity as the rodents adapt to the new environmental conditions. Read More

View Article and Full-Text PDF
September 2020

Early Chest Imaging in Patients with Puumala Hantavirus Infection.

J Belg Soc Radiol 2020 Sep 4;104(1):45. Epub 2020 Sep 4.

Université catholique de Louvain, CHU UCL Namur, Department of Radiology, 1 Avenue Dr G Thérasse, 5530, Yvoir, BE.

Purpose: To describe early chest imaging abnormalities in patients with acute Puumala virus infection.

Materials And Methods: This retrospective study (2005-2017) comprised 64 patients who were admitted to the emergency department of a Belgian hospital. These patients were diagnosed with serologically confirmed acute Puumala virus infection and had at least one chest X-ray (CRX). Read More

View Article and Full-Text PDF
September 2020

Hantavirus diseases pathophysiology, their diagnostic strategies and therapeutic approaches: A review.

Clin Exp Pharmacol Physiol 2020 Sep 7. Epub 2020 Sep 7.

Department of Biochemistry, Government College University Faisalabad, Faisalabad, Pakistan.

Hantaviruses are enveloped negative (-) single-stranded RNA viruses belongs to Hantaviridae family, hosted by small rodents and entering into the human body through inhalation, causing haemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) also known as hantavirus cardiopulmonary syndrome (HCPS). Hantaviruses infect approximately more than 200 000 people annually all around the world and its mortality rate is about 35%-40%. Hantaviruses play significant role in affecting the target cells as these inhibit the apoptotic factor in these cells. Read More

View Article and Full-Text PDF
September 2020

[Rare viral infections of the lungs].

Pneumologe (Berl) 2020 Jul 20:1-7. Epub 2020 Jul 20.

Medizinische Klinik mit Schwerpunkt Infektiologie und Pneumologie, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Deutschland.

Due to the direct contact with the environment the lungs are exposed to a multitude of viruses. This article describes four viral pathogens, which can lead to pulmonary manifestations but are little known because they are rare in Germany. Avian influenza, Middle East respiratory syndrome (MERS), and infections are all zoonotic infections, whereas measles is a purely human disease. Read More

View Article and Full-Text PDF

[Influence factors related epidemics on hantavirus disease].

Zhonghua Liu Xing Bing Xue Za Zhi 2020 Jun;41(6):968-974

National Institute for Viral Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

Hantavirus disease is a globally distributed, natural foci-related infectious disease caused by hantavirus, that maintaining persistent infections in their rodent hosts without apparent disease symptoms but seriously affecting the health safety of human beings. Development of the disease depends on the interaction between virus, rodent host and the individual person. Factors as significant geographical and seasonal variations, certain periodicity and contingency can all be related to the incidence of hantavirus disease. Read More

View Article and Full-Text PDF

Atypical case of hantavirus infection in Sri Lanka mimicking leptospirosis: a case report.

J Med Case Rep 2020 Jun 18;14(1):71. Epub 2020 Jun 18.

Department of Medicine, University of Peradeniya, Peradeniya, Sri Lanka.

Background: Hantavirus infection is an emerging zoonotic infection which has two characteristic patterns of presentation: hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome. The clinical presentation of hantavirus infection closely mimics leptospirosis.

Case Presentation: This case report describes a previously apparently well 36-year-old Sri Lankan Sinhalese man who presented with an acute febrile illness with myalgia, with liver involvement in the form of transaminitis, cardiac involvement in the form of myocarditis, acute kidney injury, and pulmonary involvement. Read More

View Article and Full-Text PDF

Development of small-molecule inhibitors against hantaviruses.

Microbes Infect 2020 Jul - Aug;22(6-7):272-277. Epub 2020 May 20.

College of Life Sciences, Hebei Agricultural University, Baoding, China. Electronic address:

Hantavirus (HV), a pathogen of animal infectious diseases that poses a threat to humans, has attracted extensive attention. Clinically, HV can cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS), between which HFRS is mostly in Eurasia, and HPS is mostly in the Americas. This paper reviews the research progress of small-molecule inhibitors of HV. Read More

View Article and Full-Text PDF

Home range variability, spatial aggregation, and excursions of Akodon azarae and Oligoryzomys flavescens in Pampean agroecosystems.

Integr Zool 2020 Sep 16;15(5):401-415. Epub 2020 Jun 16.

Laboratorio de Ecología de Poblaciones, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, and Instituto de Ecología, Genética y Evolución de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.

Rodents are reservoirs of various types of hantavirus, some of which are agents of hantavirus pulmonary syndrome in humans. Each hantavirus is associated with a single rodent host species but successive spill-over events may eventually lead to host-switching and new species' becoming host of a given pathogen. This study aims to gain an understanding of the spatial ecology of two hantavirus-host species, Akodon azarae, and Oligoryzomys flavescens, by identifying factors modulating their home range sizes and stability, and by evaluating intra- and interspecific spatial aggregation for these species and a third one-Oxymycterus rufus-living in sympatry. Read More

View Article and Full-Text PDF
September 2020

Case 12-2020: A 24-Year-Old Man with Fever, Cough, and Dyspnea.

N Engl J Med 2020 Apr;382(16):1544-1553

From the Department of Infectious Diseases, Indiana University School of Medicine, Indianapolis (N.B.); and the Departments of Radiology (S.M.), Medicine (A.K.W., S.E.T.), and Pathology (S.E.T.), Massachusetts General Hospital, and the Departments of Radiology (S.M.), Medicine (A.K.W., S.E.T.), and Pathology (S.E.T.), Harvard Medical School - both in Boston.

View Article and Full-Text PDF

Person-to-Person Transmission of Andes Virus in Hantavirus Pulmonary Syndrome, Argentina, 2014.

Emerg Infect Dis 2020 04;26(4):756-759

Andes virus is unique among hantaviruses because it can be transmitted from person to person. This mechanism was previously supported by epidemiologic data and genetic evidence based only on partial sequences. We used full-length virus sequencing to confirm person-to-person transmission of this virus in a cluster of 3 cases in Argentina in 2014. Read More

View Article and Full-Text PDF

Sociocultural determinants of adoption of preventive practices for hantavirus: A knowledge, attitudes, and practices survey in Tonosí, Panama.

PLoS Negl Trop Dis 2020 02 27;14(2):e0008111. Epub 2020 Feb 27.

Department of Research in Emerging and Zoonotic Infectious Diseases, Gorgas Memorial Institute for Health Studies, Calle 35, Panamá, PANAMA.

Introduction: Hantaviruses are a group of single-stranded RNA viruses carried by small rodent reservoirs, transmitted to humans through inhalation of aerosolized particles of rodent feces, urine, or saliva. In Panama, the Choclo orthohantavirus has been associated with Hantavirus Pulmonary Syndrome (n = 54) and Hantavirus Fever (n = 53). In 2018, there were 107 cases of hantavirus diseases, the majority in the Tonosí district, and 4 deaths. Read More

View Article and Full-Text PDF
February 2020

Long-Term Rodent Surveillance after Outbreak of Hantavirus Infection, Yosemite National Park, California, USA, 2012.

Emerg Infect Dis 2020 03;26(3):560-567

In 2012, a total of 9 cases of hantavirus infection occurred in overnight visitors to Yosemite Valley, Yosemite National Park, California, USA. In the 6 years after the initial outbreak investigation, the California Department of Public Health conducted 11 rodent trapping events in developed areas of Yosemite Valley and 6 in Tuolumne Meadows to monitor the relative abundance of deer mice (Peromyscus maniculatus) and seroprevalence of Sin Nombre orthohantavirus, the causative agent of hantavirus pulmonary syndrome. Deer mouse trap success in Yosemite Valley remained lower than that observed during the 2012 outbreak investigation. Read More

View Article and Full-Text PDF

New data about home range and movements of Oligoryzomys flavescens (Rodentia: Cricetidae) help to understand the spread and transmission of Andes virus that causes Hantavirus Pulmonary Syndrome.

Zoonoses Public Health 2020 05 7;67(3):308-317. Epub 2020 Feb 7.

Facultad de Ciencias Exactas y Naturales, Instituto de Ecología, Genética y Evolución (CONICET-UBA), Universidad de Buenos Aires, Buenos Aires, Argentina.

Hantavirus pulmonary syndrome is an emerging infectious disease caused by viruses of the genus Orthohantavirus. The rodent Oligoryzomys flavescens is distributed along four countries of South America. In Argentina, O. Read More

View Article and Full-Text PDF