257 results match your criteria Hantavirus Cardiopulmonary Syndrome


Macropinocytosis and Clathrin-Dependent Endocytosis Play Pivotal Roles for the Infectious Entry of Puumala Virus.

J Virol 2020 Apr 29. Epub 2020 Apr 29.

Department of Molecular Biophysics, Humboldt-Universität zu Berlin, Berlin, Germany

Viruses from the taxonomic family are encountered as emerging pathogens causing two life-threatening human zoonoses: hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS) with case fatalities of up to 50 %. Here we comprehensively investigated entry of the Old-World Hantavirus Puumala virus (PUUV) into mammalian cells, showing that upon treatment with pharmacological inhibitors of macropinocytosis and clathrin-mediated endocytosis PUUV infections are greatly reduced. We demonstrate that the inhibitors did not interfere with viral replication and that RNA interference, targeting cellular mediators of macropinocytosis, decreases PUUV infection levels significantly. Read More

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http://dx.doi.org/10.1128/JVI.00184-20DOI Listing

The Andes orthohantavirus NSs protein antagonizes the type I interferon response by inhibiting MAVS signaling.

J Virol 2020 Apr 22. Epub 2020 Apr 22.

Laboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Departamento de Enfermedades Infecciosas e Inmunología Pediátrica, Escuela de Medicina, Pontificia Universidad Católica de Chile, Marcoleta 391, Santiago, Chile.

The small messenger RNA (SmRNA) of the (ANDV), a rodent-borne member of the family of viruses of the order, encodes for a multifunctional nucleocapsid (N) protein and for a nonstructural (NSs) protein of unknown function. We have previously shown the expression of the ANDV-NSs, but only in infected cell cultures. In this study, we extend our early findings by confirming the expression of the ANDV-NSs protein in the lungs of experimentally infected golden Syrian hamsters. Read More

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http://dx.doi.org/10.1128/JVI.00454-20DOI Listing

Neutralizing Monoclonal Antibodies against the Gn and the Gc of the Andes Virus Glycoprotein Spike Complex Protect from Virus Challenge in a Preclinical Hamster Model.

mBio 2020 Mar 24;11(2). Epub 2020 Mar 24.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Hantaviruses are the etiological agent of hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). The latter is associated with case fatality rates ranging from 30% to 50%. HCPS cases are rare, with approximately 300 recorded annually in the Americas. Read More

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http://dx.doi.org/10.1128/mBio.00028-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157512PMC

Vaccines and Therapeutics Against Hantaviruses.

Front Microbiol 2019 30;10:2989. Epub 2020 Jan 30.

Department of Microbiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China.

Hantaviruses (HVs) are rodent-transmitted viruses that can cause hantavirus cardiopulmonary syndrome (HCPS) in the Americas and hemorrhagic fever with renal syndrome (HFRS) in Eurasia. Together, these viruses have annually caused approximately 200,000 human infections worldwide in recent years, with a case fatality rate of 5-15% for HFRS and up to 40% for HCPS. There is currently no effective treatment available for either HFRS or HCPS. Read More

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http://dx.doi.org/10.3389/fmicb.2019.02989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002362PMC
January 2020
3.941 Impact Factor

Hantavirus pulmonary syndrome in children: case report and case series from an endemic area of Brazil.

Rev Inst Med Trop Sao Paulo 2019 20;61:e65. Epub 2019 Dec 20.

Instituto Oswaldo Cruz , Laboratório de Hantaviroses e Ricktesioses , Rio de Janeiro , Rio de Janeiro , Brazil.

Hantavirus Cardiopulmonary Syndrome (HCPS) is an important emergent zoonosis associated with wild rodents in Brazil, where this viral infection in children is generally rare. We present HCPS in a child from the Pantanal Biome and a review of all reported pediatric cases in Mato Grosso State, an endemic area for HCPS in Brazil. The investigation used the Information System for Notifiable Diseases database (SINAN). Read More

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http://dx.doi.org/10.1590/S1678-9946201961065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907412PMC
February 2020

[Estimates of the spatial distribution of the relative risk of mortality of the main zoonoses in Chile: Chagas disease, hydatidosis, Hantavirus cardiopulmonary syndrome and leptospirosis].

Rev Chilena Infectol 2019 Oct;36(5):599-606

Instituto de Salud Poblacional, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

Background: Zoonoses are infections caused by all types of etiological transmissible agents from vertebrate animals to humans. During the last decades, the risk to health caused by different zoonoses has been a consequence of the natural distribution of the different etiological agents and by the emergence and reemergence of these diseases.

Aim: To study the distribution of the risk of mortality of the four main zoonoses in continental Chile, based on national mortality data, with the objective of visualizing geographically where to focus the control efforts of these diseases. Read More

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http://dx.doi.org/10.4067/S0716-10182019000500599DOI Listing
October 2019

[Sociodemographic risk factors of hantavirus cardiopulmonary syndrome].

Rev Chilena Infectol 2019 Aug;36(4):428-432

Facultad de Medicina, Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.

Background: Hantavirus cardiopulmonary syndrome (HCPS) is caused by new world hantaviruses, among which Andes hantavirus (ANDV) is endemic to Chile and Southern Argentina. The disease caused by ANDV produces plasma leakage leading to enhanced vascular permeability and has a high case fatality rate (35%), mainly due to respiratory failure, pulmonary edema and myocardial dysfunction, hypoperfusion and shock. Host sociodemographic and genetic factors might influence the course and outcome of the disease. Read More

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http://dx.doi.org/10.4067/S0716-10182019000400428DOI Listing

[Clinical laboratory criteria and its utility as predictive of diagnosis of the cardiopulmonary syndrome by hantavirus].

Rev Chilena Infectol 2019 Jun;36(3):299-303

Oficina de Investigación, Escuela de Medicina, Universidad de Valparaíso, Valparaíso, Chile.

Background: The hantavirus infection is an emerging zoonotic disease, endemic in Chile, generating the hantavirus cardiopulmonary syndrome (HCPS), characterized by cardiopulmonary dysfunction with rapidly progressive respiratory failure and high lethality. For an early clinical orientation of HCPS, due to its non-specificity in symptoms and to help the differential diagnosis, some laboratory parameter that may be useful have been studied.

Aim: To identify laboratory criteria as predictive factors of HCPS in patients with suspected hantavirus infection. Read More

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http://dx.doi.org/10.4067/S0716-10182019000300299DOI Listing

Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome.

PLoS Negl Trop Dis 2019 12 16;13(12):e0007915. Epub 2019 Dec 16.

Laboratory of Monoclonal Antibodies Technology, Immunobiological Technology Institute, FIOCRUZ, Rio de Janeiro, Brazil.

Background: Orthohantavirus infection is a neglected global health problem affecting approximately 200,000 people/year, spread by rodent hosts and associated to fatal human diseases, such as hemorrhagic fever with renal syndrome (HFRS) and orthohantavirus cardiopulmonary syndrome (HCPS). Circulation of HFRS-associated orthohantaviruses, such as Seoul, Gou, Amur, Dobrava and Hantaan, are supposed to be restricted to Eurasian countries even though their hosts can be a worldwide distribution. Few confirmed HFRS orthohantavirus infections in humans have been reported in American countries, but due to lower medical awareness of the symptoms of this zoonosis, it could be associated to viral underreporting or to misdiagnosis with several tropical hemorrhagic diseases. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913923PMC
December 2019

Comparison of targeted next-generation sequencing for whole-genome sequencing of Hantaan orthohantavirus in Apodemus agrarius lung tissues.

Sci Rep 2019 11 12;9(1):16631. Epub 2019 Nov 12.

Department of Microbiology, College of Medicine, Korea University, Seoul, 02841, Republic of Korea.

Orthohantaviruses, negative-sense single-strand tripartite RNA viruses, are a global public health threat. In humans, orthohantavirus infection causes hemorrhagic fever with renal syndrome or hantavirus cardiopulmonary syndrome. Whole-genome sequencing of the virus helps in identification and characterization of emerging or re-emerging viruses. Read More

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http://dx.doi.org/10.1038/s41598-019-53043-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851128PMC
November 2019

Spatiotemporal Dynamics of Hantavirus Cardiopulmonary Syndrome Transmission Risk in Brazil.

Viruses 2019 Oct 31;11(11). Epub 2019 Oct 31.

Department of Ecology, Institute of Biosciences, São Paulo State University (UNESP), Rio Claro 13506-900, Brazil.

Background: Hantavirus disease in humans is rare but frequently lethal in the Neotropics. Several abundant and widely distributed Sigmodontinae rodents are the primary hosts of and, in combination with other factors, these rodents can shape hantavirus disease. Here, we assessed the influence of host diversity, climate, social vulnerability and land use change on the risk of hantavirus disease in Brazil over 24 years. Read More

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http://dx.doi.org/10.3390/v11111008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893581PMC
October 2019

Hantavirus Pulmonary Syndrome in Traveler Returning from Nepal to Spain.

Emerg Infect Dis 2020 Jan 17;26(1):150-153. Epub 2020 Jan 17.

Most human hantavirus infections occur in Asia, but some cases have been described in Europe in travelers returning from Asia. We describe a case of hantavirus pulmonary syndrome in a previously healthy traveler occurring shortly after he returned to Spain from Nepal. Serologic tests suggested a Puumala virus-like infection. Read More

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http://dx.doi.org/10.3201/eid2601.181685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924883PMC
January 2020

Orthohantavirus pulmonary syndrome in Santa Cruz and Tarija, Bolivia, 2018.

Int J Infect Dis 2020 Jan 28;90:145-150. Epub 2019 Oct 28.

Universidad Franz Tamayo/UNIFRANZ, Cochabamba, Bolivia; Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia. Electronic address:

Introduction: Orthohantaviruses are still a significant public health threat in endemic countries, with high case fatality rates (CFR). In Bolivia, the reporting of small outbreaks occurred until 2012. The findings of 40 laboratory-confirmed cases diagnosed in two departments are reported herein. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.10.021DOI Listing
January 2020
1 Read

Exotic Pinus radiata Plantations do not Increase Andes Hantavirus Prevalence in Rodents.

Ecohealth 2019 12 25;16(4):659-670. Epub 2019 Oct 25.

Departamento de Ciencias Ecológicas, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile.

Andes south virus (ANDV) is the etiologic agent of hantavirus cardiopulmonary syndrome (HCPS) in Chile and southern Argentina. Farm and forestry workers have been identified as a group at high risk of acquiring HCPS caused by ANDV due to their close exposure to rodents or their secretions in rural areas. Therefore, investigation on the effect of landscape composition on ANDV in wild rodents becomes relevant for disease prevention and control. Read More

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http://dx.doi.org/10.1007/s10393-019-01443-1DOI Listing
December 2019

Clinical and anatomopathological aspects of patients with hantavirus cardiopulmonary syndrome in Uberaba, Minas Gerais, Brazil.

Rev Inst Med Trop Sao Paulo 2019 10;61:e55. Epub 2019 Oct 10.

Universidade Federal do Triângulo Mineiro, Departamento de Clínica Cirúrgica, Uberaba, Minas Gerais, Brazil.

The hantavirus cardiopulmonary syndrome is considered an emerging disease in the Americas. Since 1993, thousands of cases have been reported from different countries, but mainly from Brazil. This study aims to describe some epidemiological, clinical and anatomopathological aspects of patients with hantavirus who presented poor outcome and were autopsied in a teaching hospital in Brazil, from 2000 to 2014. Read More

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http://dx.doi.org/10.1590/S1678-9946201961055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792360PMC
October 2019
2 Reads

Hemodynamic and Pulmonary Permeability Characterization of Hantavirus Cardiopulmonary Syndrome by Transpulmonary Thermodilution.

Viruses 2019 Sep 27;11(10). Epub 2019 Sep 27.

Departamento de Paciente Crítico, Clínica Alemana de Santiago, Santiago 7650567, Chile.

Hantavirus cardiopulmonary syndrome (HCPS) is characterized by capillary leak, pulmonary edema (PE), and shock, which leads to death in up to 40% of patients. Treatment is supportive, including mechanical ventilation (MV) and extracorporeal membrane oxygenation (ECMO). Hemodynamic monitoring is critical to titrate therapy and to decide ECMO support. Read More

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http://dx.doi.org/10.3390/v11100900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832621PMC
September 2019
1 Read

A 19 Year Analysis of Small Mammals Associated with Human Hantavirus Cases in Chile.

Viruses 2019 Sep 12;11(9). Epub 2019 Sep 12.

Division of Infectious Diseases, Department of Internal Medicine, University of New Mexico, Albuquerque 87131, New Mexico.

Small mammals present in areas where hantavirus cardiopulmonary syndrome (HCPS) cases had occurred in central and southern Chile were captured and analyzed to evaluate the abundance of rodents and seroprevalence rates of antibodies to (ANDV). Sampling areas ranged from the Coquimbo to Aysén regions (30-45° S approx.) regions. Read More

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http://dx.doi.org/10.3390/v11090848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784195PMC
September 2019

Platelet Count in Patients with Mild Disease at Admission is Associated with Progression to Severe Hantavirus Cardiopulmonary Syndrome.

Viruses 2019 Jul 30;11(8). Epub 2019 Jul 30.

Escuela de Medicina. Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago 7710162, Chile.

Background: Hantavirus cardiopulmonary syndrome (HCPS) has a mortality up to 35-40% and its treatment is mainly supportive. A variable to predict progression from mild to severe disease is unavailable. This study was performed in patients with documented infection by Andes orthohantavirus, and the aim was to find a simple variable to predict progression to moderate/severe HCPS in patients with mild disease at admission. Read More

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http://dx.doi.org/10.3390/v11080693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724000PMC
July 2019
4 Reads

Quick electrochemical immunoassay for hantavirus detection based on biochar platform.

Talanta 2019 Nov 27;204:163-171. Epub 2019 May 27.

Laboratório de Sensores Eletroquímicos (LabSensE), Departamento de Química, Universidade Federal do Paraná (UFPR), CP 19032, CEP, 81531-990 Curitiba, PR, Brazil. Electronic address:

This work describes the first method using biochar (BC) as carbonaceous platform for immunoassay application. BC is a highly functionalized material obtained through biomass pyrolysis under controlled conditions. Due to the highly functionalized surface, covalent binding between BC and biomolecules can be performed by EDC/NHS conjugation. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.05.101DOI Listing
November 2019
5 Reads

Deletions in Genes Participating in Innate Immune Response Modify the Clinical Course of Andes Orthohantavirus Infection.

Viruses 2019 Jul 25;11(8). Epub 2019 Jul 25.

Programa Hantavirus, Instituto de Ciencias e Innovación en Medicina, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Av. La Plaza 680, Las Condes, Región Metropolitana 7500000, Chile.

Andes orthohantavirus (ANDV) is an important human pathogen causing hantavirus cardiopulmonary syndrome (HCPS) with a fatality rate of 30% in Chile. Around 60% of all cases have a severe clinical course, while the others have a mild clinical course. The main goal of this study was to understand if the genetic variation of patients is associated with the clinical course they develop after ANDV infection. Read More

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https://www.mdpi.com/1999-4915/11/8/680
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http://dx.doi.org/10.3390/v11080680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723883PMC
July 2019
1 Read

Vesicular Stomatitis Virus-Based Vaccines Provide Cross-Protection against Andes and Sin Nombre Viruses.

Viruses 2019 Jul 13;11(7). Epub 2019 Jul 13.

Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E3R2, Canada.

Andes virus (ANDV) and Sin Nombre virus (SNV) are the main causative agents responsible for hantavirus cardiopulmonary syndrome (HCPS) in the Americas. HCPS is a severe respiratory disease with a high fatality rate for which there are no approved therapeutics or vaccines available. Some vaccine approaches for HCPS have been tested in preclinical models, but none have been tested in infectious models in regard to their ability to protect against multiple species of HCPS-causing viruses. Read More

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http://dx.doi.org/10.3390/v11070645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669828PMC

Progress on the Prevention and Treatment of Hantavirus Disease.

Viruses 2019 Jul 4;11(7). Epub 2019 Jul 4.

Virology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.

Hantaviruses, members of the order , family , have a world-wide distribution and are responsible for greater than 150,000 cases of disease per year. The spectrum of disease associated with hantavirus infection include hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) also known as hantavirus cardiopulmonary syndrome (HCPS). There are currently no FDA-approved vaccines or treatments for these hantavirus diseases. Read More

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http://dx.doi.org/10.3390/v11070610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669544PMC
July 2019
2 Reads

Hantavirus infection in Iranian patients suspected to viral hemorrhagic fever.

J Med Virol 2019 10 5;91(10):1737-1742. Epub 2019 Jul 5.

Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran.

Background: Hantaviruses are a group of emerging pathogens causing hemorrhagic fever with renal syndrome and Hantavirus cardiopulmonary syndrome in human. This study was conducted to investigate Hantavirus infection among Iranian viral hemorrhagic fever suspected patients.

Methods: From April 2014 to June 2016, 113 cases from 25 different provinces of Iran were analyzed for Hantavirus infection by IgM/IgG ELISA and pan-Hantavirus RT-PCR tests. Read More

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http://dx.doi.org/10.1002/jmv.25522DOI Listing
October 2019
20 Reads
2.347 Impact Factor

Patients with severe orthohantavirus cardiopulmonary syndrome due to Sin Nombre Virus infection have increased circulating extracellular vesicle tissue factor and an activated coagulation system.

Thromb Res 2019 Jul 1;179:31-33. Epub 2019 May 1.

Department of Medicine, Division of Hematology and Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.thromres.2019.04.032DOI Listing

Development and Characterization of a Sin Nombre Virus Transmission Model in .

Viruses 2019 02 21;11(2). Epub 2019 Feb 21.

Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.

In North America, Sin Nombre virus (SNV) is the main cause of hantavirus cardiopulmonary syndrome (HCPS), a severe respiratory disease with a fatality rate of 35⁻40%. SNV is a zoonotic pathogen carried by deer mice (), and few studies have been performed examining its transmission in deer mouse populations. Studying SNV and other hantaviruses can be difficult due to the need to propagate the virus in vivo for subsequent experiments. Read More

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http://dx.doi.org/10.3390/v11020183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409794PMC
February 2019
8 Reads

A Single-Nucleotide Polymorphism of αβ₃ Integrin Is Associated with the Andes Virus Infection Susceptibility.

Viruses 2019 02 20;11(2). Epub 2019 Feb 20.

Departamento de Enfermedades Infecciosas e Inmunologia Pediatricas, División de Pediatría, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile.

The (ANDV), which causes the hantavirus cardiopulmonary syndrome, enters cells via integrins, and a change from leucine to proline at residue 33 in the PSI domain (L33P), impairs ANDV recognition. We assessed the association between this human polymorphism and ANDV infection. We defined susceptible and protective genotypes as "TT" (coding leucine) and "CC" (coding proline), respectively. Read More

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http://dx.doi.org/10.3390/v11020169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409546PMC
February 2019
4 Reads

Clinical Characteristics of Ratborne Seoul Hantavirus Disease.

Emerg Infect Dis 2019 02;25(2):387-388

Although Seoul orthohantavirus is the only globally spread hantavirus pathogen, few confirmed human infections with this virus have been reported in Western countries, suggesting lower medical awareness of the milder, transient, and often chameleon-like symptoms of this zoonosis. We describe lesser known clinical and laboratory characteristics to help improve underreporting of this virus. Read More

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http://dx.doi.org/10.3201/eid2502.181643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346471PMC
February 2019
7 Reads

Hantavirus RdRp Requires a Host Cell Factor for Cap Snatching.

J Virol 2019 03 19;93(5). Epub 2019 Feb 19.

Western University of Health Sciences, Pomona, California, USA

The hantavirus RNA-dependent RNA polymerase (RdRp) snatches 5' capped mRNA fragments from the host cell transcripts and uses them as primers to initiate transcription and replication of the viral genome in the cytoplasm of infected cells. Hantavirus nucleocapsid protein (N protein) binds to the 5' caps of host cell mRNA and protects them from the attack of cellular decapping machinery. N protein rescues long capped mRNA fragments in cellular P bodies that are later processed by an unknown mechanism to generate 10- to 14-nucleotide-long capped RNA primers with a 3' G residue. Read More

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http://jvi.asm.org/lookup/doi/10.1128/JVI.02088-18
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http://dx.doi.org/10.1128/JVI.02088-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384069PMC
March 2019
10 Reads

Two recombinant human monoclonal antibodies that protect against lethal Andes hantavirus infection in vivo.

Sci Transl Med 2018 11;10(468)

Faculty of Biological Science, Department of Microbiology, Center of Biotechnology, Universidad de Concepción, 4070386 Concepción, Chile.

Andes hantavirus (ANDV) is an etiologic agent of hantavirus cardiopulmonary syndrome (HCPS), a severe disease characterized by fever, headache, and gastrointestinal symptoms that may progress to hypotension, pulmonary failure, and cardiac shock that results in a 25 to 40% case-fatality rate. Currently, there is no specific treatment or vaccine; however, several studies have shown that the generation of neutralizing antibody (Ab) responses strongly correlates with survival from HCPS in humans. In this study, we screened 27 ANDV convalescent HCPS patient sera for their capacity to bind and neutralize ANDV in vitro. Read More

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http://dx.doi.org/10.1126/scitranslmed.aat6420DOI Listing
November 2018
41 Reads

Neutrophil Activation in Acute Hemorrhagic Fever With Renal Syndrome Is Mediated by Hantavirus-Infected Microvascular Endothelial Cells.

Front Immunol 2018 18;9:2098. Epub 2018 Sep 18.

Department of Virology, Medicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS) in humans. Both diseases are considered to be immunologically mediated but the exact pathological mechanisms are still poorly understood. Neutrophils are considered the first line of defense against invading microbes but little is still known of their role in virus infections. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02098
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http://dx.doi.org/10.3389/fimmu.2018.02098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157395PMC
September 2019
16 Reads

Development of a serosurveillance assay for detection of Necoclí virus exposure.

Arch Virol 2018 Dec 6;163(12):3291-3301. Epub 2018 Sep 6.

Grupo Centauro, Universidad de Antioquia U-de-A, Sede de Investigación Universitaria, SIU, Carrera 53 No. 61-30 Lab. 233, Medellín, Antioquia, Colombia.

Hantavirus cardiopulmonary syndrome (HPS) has gained importance in Latin America as an emerging disease, with reports of about 4000 HPS cases; however, this is probably an underestimate because of limited surveillance programs and diagnostic tools to confirm HPS. In order to address this issue and develop better serosurveillance capability, we evaluated three recombinant peptides from the Necoclí virus (NECV) nucleocapsid in antibody-capture ELISA. We cloned and expressed antigens representing the whole NECV nucleocapsid protein (NECV-rN), the immunodominant domain (NECV-rN100), and a serospecific domain (NECV-rN428), and then we compared these antigens in ELISA to detect IgG antibodies to NECV in human sera. Read More

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http://link.springer.com/10.1007/s00705-018-4015-3
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http://dx.doi.org/10.1007/s00705-018-4015-3DOI Listing
December 2018
19 Reads

Silent Orthohantavirus Circulation Among Humans and Small Mammals from Central Minas Gerais, Brazil.

Ecohealth 2018 09 13;15(3):577-589. Epub 2018 Aug 13.

Laboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627 - Campus Pampulha, Belo Horizonte, Minas Gerais, 31270-901, Brazil.

New World orthohantaviruses are emerging RNA viruses that cause hantavirus cardiopulmonary syndrome (HCPS). These viruses are a burden to public health around the world with a lethality rate of around 60%. In South America, rodents of Sigmodontinae subfamily are the main reservoirs of orthohantaviruses. Read More

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http://dx.doi.org/10.1007/s10393-018-1353-2DOI Listing
September 2018
9 Reads

Hantavirus Cardiopulmonary Syndrome Due to Imported Andes Hantavirus Infection in Switzerland: A Multidisciplinary Challenge, Two Cases and a Literature Review.

Clin Infect Dis 2018 11;67(11):1788-1795

Bern University Hospital and University of Bern, Switzerland.

Two travellers returning from South America were diagnosed with Andes hantavirus infection, the only member of the Hantaviridae family known to be transmitted from person to person. We describe the clinical course and therapeutic and infection control measures. While both patients showed high viral load (VL) and shedding over several months, 1 patient recovered within 1 week from severe respiratory illness that required noninvasive ventilation, whereas the second patient developed severe hantavirus cardiopulmonary syndrome that required extracorporeal membrane oxygenation for 27 days. Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
Publisher Site
http://dx.doi.org/10.1093/cid/ciy443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233683PMC
November 2018
44 Reads

Rats! Hantavirus: A Case Report of a Suspected Case in Eastern Tennessee.

Perm J 2018 07;22:17-222

Professor of Internal Medicine at the East Tennessee State University James H Quillen College of Medicine in Johnson City.

Introduction: Hantavirus is an RNA virus that is transmitted to humans by inhalation of aerosolized excrement from infected rodents. This case report demonstrates the value of taking a thorough social history and highlights the challenges associated with early diagnosis of this viral infection.

Case Presentation: We highlight a case of suspected hantavirus infection with subtle gastrointestinal and pulmonary symptoms that challenged the initial diagnosis. Read More

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http://dx.doi.org/10.7812/TPP/17-222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047851PMC
July 2018
62 Reads

The English Sweating Sickness: Out of Sight, Out of Mind?

Acta Med Acad 2018 May;47(1):102-116

Department of Medical Science, Academy of Sciences and Arts of Bosnia and Herzegovina, Sarajevo, Bosnia and Herzegovina.

In this paper we aim to add additional knowledge regarding the occurrence, origin and epidemiological features of the English sweating sickness. The English sweating sickness raged in five devastating epidemics with mortality rates between 30 and 50% between 1485 and 1551 throughout England, and on one occasion also affected mainland Europe, in 1529. The Picardy sweat, generally considered as the English sweating sickness' lesser deadly successor, flared up in France in 1718 and caused 196 localized outbreaks with varying severity all over France and neighboring countries up to 1861. Read More

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http://dx.doi.org/10.5644/ama2006-124.221DOI Listing
May 2018
8 Reads

Upregulation of P2YR, Active uPA, and PAI-1 Are Essential Components of Hantavirus Cardiopulmonary Syndrome.

Front Cell Infect Microbiol 2018 23;8:169. Epub 2018 May 23.

Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, United States.

Sin Nombre virus (SNV) causes hantavirus cardiopulmonary pulmonary syndrome (HCPS) with the loss of pulmonary vascular endothelial integrity, and pulmonary edema without causing cytopathic effects on the vascular endothelium. HCPS is associated primarily with a dysregulated immune response. We previously found occult signs of hemostatic imbalance in the form of a sharp >30-100 fold increase in the expression of plasminogen activator inhibitor type 1 (PAI-1), in serial blood plasma draws of terminal stage-patients. Read More

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http://dx.doi.org/10.3389/fcimb.2018.00169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001748PMC
June 2019
44 Reads

Hantaviruses and a neglected environmental determinant.

One Health 2018 Jun 2;5:27-33. Epub 2018 Jan 2.

Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.

Most human pathogenic hantaviruses cause severe hemorrhagic fevers with a high rate of fatalities, such as occurs due to the genotypes causing hantavirus cardiopulmonary syndrome carried by the New World Sigmodontinae and Neotominae rodents. An increasing number of outbreaks and the possibility of cases spreading over international borders have led to greater interest in these viruses and the environmental determinants that facilitate their transmission. Rodents, shrews, moles and bats act as reservoir hosts of hantaviruses, and within the hantavirus transmission flow, the prevalence and distribution of infection in reservoir hosts is influenced by a range of factors. Read More

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http://dx.doi.org/10.1016/j.onehlt.2017.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000911PMC
June 2018
13 Reads

Geographical distribution and relative risk of Anjozorobe virus (Thailand orthohantavirus) infection in black rats (Rattus rattus) in Madagascar.

Virol J 2018 05 9;15(1):83. Epub 2018 May 9.

Virology Unit, Institute Pasteur de Madagascar, Ambatofotsikely, BP 1274, Antananarivo, Madagascar.

Background: Hantavirus infection is a zoonotic disease that is associated with hemorrhagic fever with renal syndrome and cardiopulmonary syndrome in human. Anjozorobe virus, a representative virus of Thailand orthohantavirus (THAIV), was recently discovered from rodents in Anjozorobe-Angavo forest in Madagascar. To assess the circulation of hantavirus at the national level, we carried out a survey of small terrestrial mammals from representative regions of the island and identified environmental factors associated with hantavirus infection. Read More

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http://dx.doi.org/10.1186/s12985-018-0992-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944027PMC
May 2018
26 Reads

A High-Throughput Flow Cytometry Screen Identifies Molecules That Inhibit Hantavirus Cell Entry.

SLAS Discov 2018 08 2;23(7):634-645. Epub 2018 Apr 2.

1 Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, USA, and in revised form Feb 15, 2018. Accepted for publication Mar 1, 2018.

Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), which infects more than 200,000 people worldwide. Sin Nombre virus (SNV) and Andes virus (ANDV) cause the most severe form of HCPS, with case fatality ratios of 30%-40%. There are no specific therapies or vaccines for SNV. Read More

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http://dx.doi.org/10.1177/2472555218766623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469676PMC
August 2018
8 Reads

A Nonfatal Case of Dobrava Hantavirus Hemorrhagic Fever with Renal Syndrome Combined with Hantavirus Cardiopulmonary Syndrome.

J Glob Infect Dis 2018 Jan-Mar;10(1):22-25

Institute of Public Health, Prishtina, Kosovo.

Among hantaviruses (HTNV), 22 are known as pathogenic for humans. HTNV can cause two clinical entities: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome or hantavirus cardiopulmonary syndrome (HCPS). In most countries of Eastern Europe as well as in Kosovo, HTNV infection is presented mainly as HFRS. Read More

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http://dx.doi.org/10.4103/jgid.jgid_12_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850759PMC
March 2018
28 Reads

Differential Regulation of PAI-1 in Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever With Renal Syndrome.

Open Forum Infect Dis 2018 Feb 17;5(2):ofy021. Epub 2018 Jan 17.

Department of Virology, Medicum, Faculty of Medicine, University of Helsinki, Helsinki, Finl.

We analyzed the levels of circulating tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI)-1 in acute hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS). The levels of tPA commonly increased in both diseases, whereas PAI-1 correlated with disease severity in HCPS but not in HFRS. Read More

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https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofy02
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http://dx.doi.org/10.1093/ofid/ofy021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808793PMC
February 2018
39 Reads

Hantavirus induced cardiopulmonary syndrome: A public health concern.

J Med Virol 2018 06 15;90(6):1003-1009. Epub 2018 Mar 15.

Saint Joseph's Hospital Medical Center, Phoenix, Arizona.

Hantavirus cardiopulmonary syndrome is characterized by pulmonary capillary leakage and alveolar flooding, resulting in 50% mortality due to fulminant hypoxic respiratory failure. In addition, depression of cardiac function ensues, which complicates the picture with cardiogenic shock. Early diagnosis and appropriate use of extracorporeal membrane oxygenation (ECMO) are amongst the lifesaving interventions in this fatal illness. Read More

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http://dx.doi.org/10.1002/jmv.25054DOI Listing
June 2018
22 Reads
2.350 Impact Factor

Quantification and kinetics of viral RNA transcripts produced in Orthohantavirus infected cells.

Virol J 2018 01 19;15(1):18. Epub 2018 Jan 19.

Swedish Defence Research Agency, CBRN Defence and Security, Umeå, Sweden.

Background: Rodent borne viruses of the Orthohantavirus genus cause hemorrhagic fever with renal syndrome among people in Eurasia, and hantavirus cardiopulmonary syndrome in the Americas. At present, there are no specific treatments or efficient vaccines against these diseases. Improved understanding of viral transcription and replication may instigate targeted treatment of Orthohantavirus infections. Read More

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https://virologyj.biomedcentral.com/articles/10.1186/s12985-
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http://dx.doi.org/10.1186/s12985-018-0932-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775559PMC
January 2018
12 Reads
2.181 Impact Factor

First serologic evidence of human hantavirus infection in Alagoas State in Northeastern Brazil.

Rev Soc Bras Med Trop 2017 Nov-Dec;50(6):819-823

Laboratório de Pesquisas em Virologia e Imunologia, Instituto de Ciências Biológicas e da Saúde, Universidade Federal Alagoas, Maceió, AL, Brasil.

Introduction: Hantavirus cardiopulmonary syndrome (HCPS) is rare in Northeastern Brazil.

Methods: Prospective surveillance was conducted over a two-year period in Alagoas State, Northeastern Brazil. The prevalence of anti-hantavirus N-antigen IgM and IgG in human serum samples was determined by enzyme-linked immunosorbent assay testing. Read More

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http://dx.doi.org/10.1590/0037-8682-0117-2017DOI Listing
April 2018
14 Reads

[Human hantavirus infections].

Zentralbl Arbeitsmed Arbeitsschutz Ergon 2018 28;68(2):94-97. Epub 2018 Feb 28.

Institut für Arbeitsmedizin, Sozialmedizin und Umweltmedizin, Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Deutschland.

Hantaviruses belong to the family. A large number of different subtypes are known worldwide that show a host-specific geographical distribution. Humans may become infected through contact with rodent urine, saliva or feces. Read More

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http://dx.doi.org/10.1007/s40664-017-0223-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123101PMC
February 2018

Seropositivity diagnosis for hantavirus in Jataí, Goiás State, Brazil.

Rev Soc Bras Med Trop 2017 Jul-Aug;50(4):530-534

Instituto de Ciências da Saúde, Universidade Federal de Goiás, Jataí, GO, Brasil.

Introduction:: Emerging diseases are of great interest, especially those associated with high mortality rates such as hantaviruses. We aimed to conduct a seroepidemiological survey to determine the levels of hantavirus infection.

Methods:: In-house enzyme-linked immunosorbent assay (ELISA) was used to detect specific antibodies. Read More

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http://dx.doi.org/10.1590/0037-8682-0035-2017DOI Listing
November 2017
49 Reads

A neuropathic pain syndrome associated with hantavirus infection.

J Neurovirol 2017 12 11;23(6):919-921. Epub 2017 Sep 11.

Division of Neurology, Department of Medicine, Neuroscience and Mental Health Institute, University of Alberta, 7-132A Clinical Sciences Building, 11350-83 Ave, Edmonton, Alberta, T6G 2G3, Canada.

Hantaviruses are a group of single-stranded RNA viruses of the Bunyaviridae family. "New World" hantaviruses cause hantavirus cardiopulmonary syndrome (HCPS) in North America. HCPS carries with it significant mortality and those patients who survive the disease are often left with substantial morbidity. Read More

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http://dx.doi.org/10.1007/s13365-017-0576-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095002PMC
December 2017
24 Reads

Co-circulation of Araraquara and Juquitiba Hantavirus in Brazilian Cerrado.

Microb Ecol 2018 Apr 31;75(3):783-789. Epub 2017 Aug 31.

Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Pavilhão Helio e Peggy Pereira - 1° Pav. Sala B115, Av. Brasil 4365, Manguinhos, Rio de Janeiro, RJ, 21045-900, Brazil.

Hantavirus cardiopulmonary syndrome is an emerging serious disease in the Americas, transmitted from wild rodents to humans through inhalation of aerosol containing virus. Herein, we characterized two distinct hantaviruses circulating in rodent species form Central Plateau, Midwestern region of Brazil in the Cerrado (savanna-like) biome, an area characterized by small trees and grasses adapted to climates with long dry periods. In this study, we identified the co-circulation of the Araraquara virus and a possible new lineage of the Juquitiba virus (JUQV) in Oligoryzomys nigripes. Read More

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http://dx.doi.org/10.1007/s00248-017-1061-4DOI Listing
April 2018
77 Reads

Climate change and sugarcane expansion increase Hantavirus infection risk.

PLoS Negl Trop Dis 2017 Jul 20;11(7):e0005705. Epub 2017 Jul 20.

Department of Ecology, Bioscience Institute, University of São Paulo, São Paulo, São Paulo, Brazil.

Hantavirus Cardiopulmonary Syndrome (HCPS) is a disease caused by Hantavirus, which is highly virulent for humans. High temperatures and conversion of native vegetation to agriculture, particularly sugarcane cultivation can alter abundance of rodent generalist species that serve as the principal reservoir host for HCPS, but our understanding of the compound effects of land use and climate on HCPS incidence remains limited, particularly in tropical regions. Here we rely on a Bayesian model to fill this research gap and to predict the effects of sugarcane expansion and expected changes in temperature on Hantavirus infection risk in the state of São Paulo, Brazil. Read More

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http://dx.doi.org/10.1371/journal.pntd.0005705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519001PMC
July 2017
25 Reads