3,184 results match your criteria Handbook of Experimental Pharmacology [Journal]


Levonorgestrel Intrauterine System associated amenorrhea: a systematic review and meta-analysis.

Am J Obstet Gynecol 2018 Dec 7. Epub 2018 Dec 7.

FHI 360, Contraceptive Technology Innovation, 359 Blackwell Street, Suite #200, Durham, North Carolina, 27701 United States.

Background: Amenorrhea is a polarizing non-contraceptive effect of the Levonorgestrel Intrauterine System (LNG-IUS). Composite amenorrhea prevalence estimates summarizing all clinical data for the first-year post-insertion is currently not available.

Objective: To investigate the validity of existing prevalence estimates by systematically calculating amenorrhea measures for a general population of LNG-IUS users and provide 90-day interval point estimates for the first-year of use. Read More

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December 2018

Integrative Herbal Medicine for Chemotherapy-Induced Peripheral Neuropathy and Hand-Foot Syndrome in Colorectal Cancer: A Systematic Review and Meta-Analysis.

Integr Cancer Ther 2018 Dec 10:1534735418817833. Epub 2018 Dec 10.

1 Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine, and The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China.

Objectives: To assess the clinical evidence for integrative herbal medicine therapy in the management of chemotherapy-induced peripheral neuropathy (CIPN) and hand-foot syndrome (HFS) resulting from treatments for colorectal cancer (CRC).

Design: Randomized controlled trials (RCTs) were identified from major English and Chinese databases. Participants had been diagnosed with CRC by pathology and had received or were undergoing chemotherapy. Read More

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December 2018

Effect of instrumentation systems on endotoxin reduction from root canal systems: A systematic review of clinical studies and meta-analysis.

Aust Endod J 2018 Dec 5. Epub 2018 Dec 5.

Department of Restorative Dentistry, Endodontics Division, Piracicaba Dental School, State University of Campinas - UNICAMP, Piracicaba, São Paulo, Brazil.

This systematic review assessed the effect of different root canal instrumentation systems on endotoxin reduction from the root canal system. The literature search was conducted in two electronic databases (PubMed and Scopus) using specific key words. The search strategy followed the PRISMA guidelines. Read More

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December 2018
1 Read

Thoracic epidural analgesia (TEA) versus patient-controlled analgesia (PCA) in laparoscopic colectomy: a systematic review and meta-analysis.

Int J Colorectal Dis 2018 Dec 5. Epub 2018 Dec 5.

Department of Surgery, University Hospital of Larissa, Mezourlo, 41110, Larissa, Greece.

Purpose: A meta-analysis of RCTs was designed to provide an up-to-date comparison of thoracic epidural analgesia (TEA) and patient-controlled analgesia (PCA) in laparoscopic colectomy.

Methods: Our study was completed following the PRISMA guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. A systematic literature screening was performed in MEDLINE and Web of Science. Read More

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December 2018

Dopamine in critically ill patients with cardiac dysfunction: A systematic review with meta-analysis and trial sequential analysis.

Acta Anaesthesiol Scand 2018 Dec 4. Epub 2018 Dec 4.

Department of Critical Care, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: Dopamine has been used in patients with cardiac dysfunction for more than five decades. Yet, no systematic review has assessed the effects of dopamine in critically ill patients with cardiac dysfunction.

Methods: This systematic review was conducted following The Cochrane Handbook for Systematic Reviews of Interventions. Read More

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December 2018
3 Reads

[Comparison of the effect of navigation template assisted spinal pedicle fixation and traditional pedicle screw fixation:a Meta-analysis].

Zhongguo Gu Shang 2018 Nov;31(11):1069-1076

Department of Orthopaedics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China;

Objective: To systematically evaluate the efficacy of rapid prototyping drill navigation template-assisted pedicle screw fixation and traditional anatomic landmark-based fixation in the treatment of spinal disease by accessing and searching some relevant literatures home and abroad.

Methods: Randomized Controlled Trials (RCTs) and prospective case-control studies or retrospective case-control studies about rapid prototyping drill templates-assisted pedicle screw fixation and traditional anatomic landmark-based fixation for the treatment of spinal disease were searched electronically in PubMed, The Cochrane Library(Issue 5, 2017), Clinical Trial, Google Scholar, Web of Science, CNKI, Wanfang database and VIP database before June 2017. According to the inclusion and exclusion criteria, two researchers independently screened the literatures, and extracted the data. Read More

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November 2018
1 Read

Effects of exercise interventions for specific cognitive domains in old adults with mild cognitive impairment: A protocol of subgroup meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2018 Nov;97(48):e13244

School of Nursing, Medical College of Huzhou University.

Background: Mild cognitive impairment (MCI) is the clinical prognosis that leads to dementia. Early intervention of MCI is critical to protect against dementia. Exercise intervention has gained popularity for the management of MCI. Read More

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November 2018

Evaluation of Antibiotic Prophylaxis in Rhinoplasty: A Systematic Review and Meta-analysis.

JAMA Facial Plast Surg 2018 Nov 29. Epub 2018 Nov 29.

Department of Physical and Rehabilitation Medicine, Turku University Hospital, University of Turku, Turku, Finland.

Importance: Although antibiotic prophylaxis following rhinoplasty is widespread, the evidence on antibiotic prophylaxis effectiveness and the superiority of particular administration regimens is controversial. To date, a meta-analysis on the topic has not been performed.

Objective: To systematically review the association between use of preventive antibiotics and postoperative complications in patients undergoing rhinoplasty and quantify the review through meta-analysis. Read More

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November 2018
1 Read

Effectiveness of mindfulness-based stress reduction (MBSR) on symptom variables and health-related quality of life in breast cancer patients-a systematic review and meta-analysis.

Support Care Cancer 2018 Nov 28. Epub 2018 Nov 28.

Department of Nursing, The Affiliated Hospital of Nanjing University, Nanjing Drum Tower Hospital, Nanjing, 210008, Jiangsu, China.

Objective: The purpose of this systematic review and meta-analysis was to evaluate the effectiveness of mindfulness-based stress reduction (MBSR) in breast cancer patients.

Methods: A systematic search of Cochrane Library, Cochrane Central Register of Controlled Trials, PsycINFO database, Web of science, Medline, EMBASE, CNKI, and CBM database was carried out from February to May 2018, with no language restrictions. Trials examining the effects of MBSR versus control group on symptom variables and health-related quality of life were included. Read More

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November 2018

Adjunctive virtual reality for procedural pain management of burn patients during dressing change or physical therapy: A systematic review and meta-analysis of randomized controlled trials.

Wound Repair Regen 2018 Nov 27. Epub 2018 Nov 27.

Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, China.

Dressing change and physical therapy are extremely painful procedures for burn patients. Adjunctive virtual reality therapy reportedly reduces pain when added to analgesics, but a summary analysis of the data has yet to be performed. We conducted this systematic review and meta-analysis of randomized controlled trials to verify the pain-reducing efficacy of virtual reality among burn patients undergoing dressing change or physical therapy. Read More

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November 2018
5 Reads

Ezetimibe for the prevention of cardiovascular disease and all-cause mortality events.

Cochrane Database Syst Rev 2018 11 19;11:CD012502. Epub 2018 Nov 19.

Pharmacy Department, First Affiliated Hospital of Third Military Medical University (Army Medical University), 30 Gaotanyan Street, Shapingba District, Chongqing, China, 400038.

Background: Cardiovascular disease (CVD) remains an important cause of mortality and morbidity, and high levels of blood cholesterol are thought to be the major modifiable risk factors for CVD. The use of statins is the preferred treatment strategy for the prevention of CVD, but some people at high-risk for CVD are intolerant to statin therapy or unable to achieve their treatment goals with the maximal recommended doses of statin. Ezetimibe is a selective cholesterol absorption inhibitor, whether it has a positive effect on CVD events remains uncertain. Read More

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November 2018
5 Reads

Protective effect of soursop ( linn.) juice on oxidative stress in heat stressed rabbits.

J Anim Sci Technol 2018 16;60:28. Epub 2018 Nov 16.

Department of Agricultural Technology, Federal Polytechnic Ado Ekiti, Ado Ekiti, Ekiti State Nigeria.

Background: Preventing oxidative stress in heat stressed animals may be possible by increasing antioxidant defence via exogenous administration of antioxidant substrate and/or its precursors. The study aimed to investigate the effect of Soursop juice in mitigating oxidative stress induced by heat stress in rabbit.

Methods: Sixty mixed breed rabbit bucks aged 12-18 months old with the average weight of 1826 ± 8. Read More

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November 2018

Incidence of incisional hernias following single-incision versus traditional laparoscopic surgery: a meta-analysis.

Hernia 2018 Nov 23. Epub 2018 Nov 23.

General Surgery, Kingston Health Sciences Centre, 76 Stuart Street, Burr 2, Kingston, ON, K7L 2V7, Canada.

Purpose: To compare, using a meta-analysis of randomized controlled trials, the risk of incisional hernia in patients undergoing single-incision laparoscopic surgery to those undergoing traditional laparoscopic surgery.

Methods: MEDLINE and EMBASE databases were searched. Randomized controlled trials comparing single-incision laparoscopic surgery to traditional laparoscopic surgery and which reported incisional hernias over a minimum 6-month follow-up period were eligible. Read More

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November 2018
3 Reads

Rehabilitation via HOMe Based gaming exercise for the Upper-limb post Stroke (RHOMBUS): protocol of an intervention feasibility trial.

BMJ Open 2018 Nov 21;8(11):e026620. Epub 2018 Nov 21.

Centre for Cognitive Neuroscience, College of Health and Life Sciences, Brunel University, London, UK.

Introduction: Effective interventions to promote upper-limb recovery poststroke are characterised by intensive and repetitive movements. However, the repetitive nature of practice may adversely impact on adherence. Therefore, the development of rehabilitation devices that can be used safely and easily at home, and are motivating, enjoyable and affordable is essential to the health and well-being of stroke survivors. Read More

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November 2018
11 Reads

Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials.

Phytomedicine 2018 Nov 28;50:25-34. Epub 2018 Sep 28.

Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.. Electronic address:

Background: In recent years, berberine has become widely used as an effective alternative to treat dyslipidaemias; much clinical evidence has emerged. It is important to systematically and critically evaluate the existing evidence.

Purpose: This study aims to evaluate the efficacy and safety of berberine in patients with dyslipidaemias. Read More

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November 2018
2 Reads

Total parenteral nutrition versus early enteral nutrition after cystectomy: a meta-analysis of postoperative outcomes.

Int Urol Nephrol 2018 Nov 21. Epub 2018 Nov 21.

Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, People's Republic of China.

Background: This study aimed to systematically summarize and analyze the current evidence regarding the effect of total parenteral nutrition (TPN) versus early enteral nutrition (EEN) on postoperative outcomes of cystectomy.

Methods: A comprehensive search of online databases was conducted to identify comparative studies on the postoperative outcomes of patients receiving TPN and EEN after cystectomy. Our subsequent meta-analysis followed the PRISMA Protocol and the Cochrane Handbook. Read More

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November 2018
1 Read

Scientific evidence for the management of dentin caries lesions in pediatric dentistry: A systematic review and network meta-analysis.

PLoS One 2018 21;13(11):e0206296. Epub 2018 Nov 21.

Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil.

Background: A systematic quantitative evaluation of the available evidence of the treatment for caries lesions in primary teeth that considers how different caries progressions lead to the need for distinct interventions might provide additional useful information for clinical evidence-based decision making. The aim of this systematic review and network meta-analysis was to verify the effect of the treatments on caries lesion arrestment (CLA) or the success rate (SR) of dentin caries lesion treatments in the primary teeth.

Methods: A search was conducted using the MEDLINE/PubMed, Web of Science and Scopus databases through December 2017. Read More

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November 2018
3 Reads

Use of Dental Practices for the Identification of Adults With Undiagnosed Type 2 Diabetes Mellitus or Nondiabetic Hyperglycemia: Protocol for a Systematic Review.

JMIR Res Protoc 2018 Nov 19;7(11):e11843. Epub 2018 Nov 19.

Department of Health Sciences, University of Leicester, Leicester, United Kingdom.

Background: Type 2 diabetes mellitus (T2DM) is a growing global health burden and is expected to affect more than 590 million people by the year 2035. Evidence exists to demonstrate that dental settings have been used for risk assessment and identification of individuals who may be at high risk for T2DM or who may already unknowingly have the condition.

Objective: This protocol aims to outline the methodology that will be undertaken to synthesize the literature relating to the use of primary care (nonhospital-based) dental services for the identification of undiagnosed T2DM or prediabetes-often termed nondiabetic hyperglycemia-in adult patients. Read More

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November 2018
3 Reads

[Efficacy and safety of breviscapine injection in treatment of unstable angina pectoris: systematic review and Meta-analysis].

Zhongguo Zhong Yao Za Zhi 2018 Oct;43(19):3940-3955

Institute of Basic Research Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.

To systematically evaluate the efficacy and safety of breviscapine injection in the treatment of unstable angina pectoris (UAP). Eight electronic databases and clinical trials registries were searched to collect randomized controlled trials on breviscapine injection in the treatment of UAP. According to the evaluation standards in Cochrane Handbook 5. Read More

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October 2018
1 Read

Association of traditional Chinese exercises with glycemic responses in people with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials.

J Sport Health Sci 2018 Oct 25;7(4):442-452. Epub 2018 Aug 25.

Department of Sports Rehabilitation, Shanghai University of Sport, Shanghai 200438, China.

Background: There is increasing evidence showing the health benefits of various forms of traditional Chinese exercises (TCEs) on the glycemic profile in people with type 2 diabetes. However, relatively little is known about the combined clinical effectiveness of these traditional exercises. This study was designed to perform a systematic review and meta-analysis of the overall effect of 3 common TCEs (Tai Ji Quan, Qigong, Ba Duan Jin) on glycemic control in adults with type 2 diabetes. Read More

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October 2018
5 Reads

Nonhuman biota dose rate estimation from liquid effluent releases during normal operations of light water reactors using the LADTAP II computer code.

Authors:
Sunita Kamboj

J Environ Radioact 2019 Jan 16;196:141-149. Epub 2018 Nov 16.

Argonne National Laboratory, 9700 Cass Avenue, Argonne, IL, 60439, USA. Electronic address:

The LADTAP II computer code was used to estimate the dose rates to seven nonhuman biota (fish, algae, invertebrate, muskrat, raccoon, heron, and duck) from liquid effluent releases during the normal operations of new light water reactor facilities in the United States. The estimated dose rates to nonhuman biota depended on the nuclear power plant design but were orders of magnitude less than the 'derived consideration reference levels' (DCRL) in International Commission on Radiological Protection (ICRP) Publication 108. The estimated dose rates were at least three orders of magnitude lower than the guideline values identified by the International Atomic Energy Agency (IAEA) and the National Council on Radiation Protection and Measurements to cause observable changes in populations of biota. Read More

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January 2019
1 Read

The use of steroids to reduce complications after tonsillectomy: a systematic review and meta-analysis of randomized controlled studies.

Eur Arch Otorhinolaryngol 2018 Nov 17. Epub 2018 Nov 17.

Department of Otolaryngology, King Chulalongkorn Memorial Hospital, 1873 Rama 4 road, Pathumwan, Bangkok, 10330, Thailand.

Objectives: To systemically review and compare the efficacy of intravenous, local, and oral steroids in decreasing post-tonsillectomy pain, nausea, and vomiting, and its risk of causing hemorrhage.

Methods: We searched electronic databases (PubMed, Scopus, Cochrane Library) and additional sources. The date of the most recent search was June 20th, 2018. Read More

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November 2018
7 Reads

The effect of vitamin D supplementation on oxidative stress parameters: A systematic review and meta-analysis of clinical trials.

Pharmacol Res 2018 Nov 15;139:141-152. Epub 2018 Nov 15.

Department of Nutritional Science, School of Nutritional Science and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:

Recent studies have shown that vitamin D supplementation beneficially decreases oxidative stress (OS) parameters; however, there is no consensus on this subject. In this systematic review and meta-analysis we aimed to investigate the effect of vitamin D supplementation on OS parameters. We searched electronic databases including Medline, Embase, Scopus, Web of Science and Cochrane Library up to July 2018 without any language restriction. Read More

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November 2018
3 Reads

Modafinil for poststroke patients: A systematic review.

Int J Clin Pract 2018 Nov 16:e13295. Epub 2018 Nov 16.

Cochrane Brazil, São Paulo, Brazil.

Introduction: Stroke is a major cause of death and disability worldwide. The use of modafinil, a wakefulness-promoting agent, is hypothesised to benefit stroke patients.

Methods: We performed a systematic review in accordance with the Cochrane Handbook for Systematic Reviews of Interventions recommendations to assess the efficacy and safety of modafinil in poststroke patients. Read More

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November 2018
6 Reads
2.566 Impact Factor

Does the Humanitarian Sector Use Evidence-informed Standards? A Review of the 2011 Sphere Indicators for Wash, Food Security and Nutrition, and Health Action.

PLoS Curr 2018 Oct 30;10. Epub 2018 Oct 30.

Health in Humanitarian Crises Centre, London School of Hygiene & Tropical Medicine (LSHTM), London, United Kingdom.

Background: In 1997, the pursuit of greater accountability and effectiveness in humanitarian response prompted a multi-stakeholder collaboration to develop a set of indicators and standards to guide humanitarian practitioners, published later in the form of the Sphere Handbook. Twenty years after the first edition of the Handbook was developed, and in order to guide the 2018 revision, an assessment of the evidence base for current Water, Sanitation and Hygiene (WASH), Food Security and Nutrition, and Health Action indicators, as compared to evidence collated by the 2015 LSHTM Humanitarian Health Evidence Review (HHER), was conducted.

Methodology: In order to assess the utility of the Sphere indicators as a tool with which to monitor and evaluate humanitarian activities, indicators from the WASH, Food Security and Nutrition, and Health Action chapters of the Sphere Handbook were analysed and classified according to the SMART criteria. Read More

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October 2018

Efficacy of vitamin D in treatment of inflammatory bowel disease: A meta-analysis.

Medicine (Baltimore) 2018 Nov;97(46):e12662

Department of Gastroenterology.

Background: Vitamin D (VitD) deficiency is prevalent in patient with inflammatory bowel disease (IBD). Recent studies have found that VitD can induce and maintain IBD remission through antibiosis, anti-inflammatory, and repair of intestinal mucosal barriers, thus improving the patient's disease activity and quality-of-life. The purpose of this meta-analysis is to evaluate the therapeutic effect and safety of VitD in the treatment of IBD. Read More

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November 2018
23 Reads

The effect of statin treatment on circulating coenzyme Q10 concentrations: an updated meta-analysis of randomized controlled trials.

Eur J Med Res 2018 Nov 10;23(1):57. Epub 2018 Nov 10.

China Heart Institute of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.

Background: The effect of statin treatment on circulating coenzyme Q10 (CoQ10) has been studied in numerous randomized controlled trails (RCTs). However, whether statin treatment decreases circulating CoQ10 is still controversial.

Methods: PubMed, EMBASE, and the Cochrane Library were searched to identify RCTs to investigate the effect of statin treatment on circulating CoQ10. Read More

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November 2018
3 Reads

Mental Health Integration in Geriatric Patient-Aligned Care Teams in the Department of Veterans Affairs.

Am J Geriatr Psychiatry 2018 Sep 13. Epub 2018 Sep 13.

Center for Healthcare Organization and Implementation Research (OA, JLS), VA Boston Healthcare System, Boston, MA; Boston University School of Public Health (JLS), Boston, MA.

Objectives: To inform geriatric mental health policy by describing the role of behavioral healthcare providers within a geriatric patient-aligned care team (GeriPACT), a patient-centered medical home model of care within the Veterans Health Administration (VHA), serving older veterans with chronic disease, functional dependency, cognitive decline, and psychosocial challenges, and/or those who have elder abuse, risk of long-term care placement, or impending disability.

Methods: The authors used mixed methods, consisting of a national survey and site visits between July 2016 and February 2017, at VHA outpatient clinics. The participants, 101 GeriPACTs at 44 sites, completed surveys, and 24 medical providers were interviewed. Read More

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September 2018
2 Reads

Perioperative alcohol cessation intervention for postoperative complications.

Cochrane Database Syst Rev 2018 11 8;11:CD008343. Epub 2018 Nov 8.

Orthopaedic Department, Hospital of Southern Jutland, University of Southern Denmark, Aabenraa, Denmark, 6200.

Background: Risky consumption of alcohol is a global problem. More than 3.3 million deaths annually are associated with risky use of alcohol, and global alcohol consumption continues to increase. Read More

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November 2018
4 Reads

Statistical methods and reporting practices in the study of dyslexia.

Dyslexia 2018 Nov 8. Epub 2018 Nov 8.

Literacy Studies Program, College of Education, Middle Tennessee State University, Murfreesboro, Tennessee.

This report presents findings from a review of the journals Dyslexia and Annals of Dyslexia over a 10-year period from 2005 to 2014. Three hundred articles were reviewed to examine statistical methodology and reporting practices. Articles were coded according to their reported covariates, effect sizes, and statistical methods. Read More

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November 2018
6 Reads

Correlates of cognitive impairment in chronic kidney failure patients on hemodialysis: Systematic review and meta-analysis.

J Adv Nurs 2018 Nov 8. Epub 2018 Nov 8.

Department of Nursing, Inha University, Incheon, Republic of Korea.

Aim: To review and identify correlates of cognitive impairment in chronic kidney failure patients on hemodialysis.

Background: The literature is consistent regarding the high prevalence of cognitive impairment among chronic kidney failure patients on hemodialysis and its dependence on multidimensional risk factors.

Design: Systematic review and meta-analysis based on Cochrane Handbook and PRISMA. Read More

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November 2018
8 Reads

Acupressure for insomnia: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2018 Nov;97(45):e13180

Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.

Background: Insomnia is a public sleep disorder defined as a deficiency of sleep quantity or quality. Acupressure is a low-cost treatment that has potential as an insomnia therapy.

Methods: Four databases will be searched from inception to date. Read More

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November 2018
1 Read

Clinical efficacy and safety of traditional Chinese patent medicine for hyperthyroid heart disease: study protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2018 Nov;97(45):e13076

Guang'anmen Hospital of China Academy of Chinese Medical Sciences.

Background: Hyperthyroid heart disease (HHD), one of the most common complications of hyperthyroidism, is a serious public health problem due to the direct toxic or indirect effects of excessive thyroid hormone on the heart, resulting in high mortality and increasing health care costs. Traditional Chinese patent medicines (TCPMs), developed by combining modernized pharmaceutical technologies with ancient TCM theories, have been widely used in the treatment of HHD. However, the safety and efficacy of TCPMs used in patients with HHD has been uncertain and there has been no standard clinical trial published to confirm this. Read More

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November 2018
6 Reads

Association between mitochondrial DNA copy number and cardiovascular disease: Current evidence based on a systematic review and meta-analysis.

PLoS One 2018 7;13(11):e0206003. Epub 2018 Nov 7.

Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.

Background: Mitochondria are energy-producing structure of the cell and help to maintain redox environment. In cardiovascular disease, the number of mitochondrial DNA (mtDNA) will changes accordingly compare to normal condition. Some investigators ask whether it has a clear association between mtDNA and cardiovascular disease with its adverse events. Read More

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November 2018
5 Reads
3.234 Impact Factor

Laparoscopic Gastric Plication versus Laparoscopic Sleeve Gastrectomy: An Up-to-Date Systematic Review and Meta-Analysis.

J Obes 2018 9;2018:3617458. Epub 2018 Oct 9.

Department of Surgery, University Hospital of Larissa, Mezourlo, 41110 Larissa, Greece.

Introduction: A meta-analysis was conducted in order to provide an up-to-date comparison of laparoscopic sleeve gastrectomy (LSG) and laparoscopic gastric plication (LGP) for morbid obesity.

Materials And Methods: The PRISMA guidelines and were used for the conduction of this study. A systematic literature search was performed in the electronic databases (MEDLINE, CENTRAL, and Web of Science and Scopus). Read More

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October 2018
3 Reads

The Handbook of Minerals on a Gluten-Free Diet.

Authors:
Iga Rybicka

Nutrients 2018 Nov 5;10(11). Epub 2018 Nov 5.

Faculty of Commodity Science, Poznań University of Economics and Business, 61-875 Poznań, Poland.

The importance of a gluten-free diet (GFD) in the treatment of celiac disease and other gluten-related disorders is undisputable. However, strict GFD often lead to nutritional imbalances and, therefore, to deficiencies. One of the most common deficiencies from a GFD are an insufficient amount of Ca, Fe, Mg, and Zn. Read More

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November 2018
4 Reads

Autograft or Allograft? Irradiated or Not? A Contrast Between Autograft and Allograft in Anterior Cruciate Ligament Reconstruction: A Meta-analysis.

Arthroscopy 2018 Dec 2;34(12):3258-3265. Epub 2018 Nov 2.

Center for Sport Medicine, First Affiliated Hospital, College of Medicine Zhejiang University, Hangzhou, China. Electronic address:

Purpose: To compare the clinical outcomes and adverse events associated with irradiated and nonirradiated allografts in anterior cruciate ligament (ACL) reconstruction.

Methods: PubMed, Web of Science, and EMBASE were searched for randomized controlled trials from January 1990 to March 2018 to compare autograft with allograft in ACL reconstruction. Both objective and subjective outcomes of the function and adverse events were meta-analyzed. Read More

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December 2018
4 Reads

My brief but spectacular career in hockey: A life lesson.

Clin Invest Med 2018 Nov 3;41:24-25. Epub 2018 Nov 3.

Department of Pediatrics, Faculty of Medicine, Dalhousie University, Halifax, NS.

Bob is a pediatric infectious disease specialist at Dalhousie University, where he did research on the ontogeny of the immune system in neonates. He was VP Research at the IWK Health Centre (1992-2007). He developed the curriculum for a CIHR train-ing program and edited "Handbook for Clinician Scientists". Read More

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November 2018
8 Reads

The effectiveness of music therapy for terminally ill patients:A meta-analysis and systematic review.

J Pain Symptom Manage 2018 Oct 30. Epub 2018 Oct 30.

School of Public Health, Lanzhou University, Gansu, China. Electronic address:

Context: The quality of death has increasingly raised concern because of the physical and psychological suffering of patients with advanced disease. Music therapy has been widely used in palliative care; however, its physical and mental effectiveness remains unclear.

Objective: To assess the effectiveness of music therapy during palliative care in improving physiology and psychology outcomes. Read More

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October 2018
6 Reads

Student perspectives on managing sickle cell disease at school.

Pediatr Blood Cancer 2018 Nov 1:e27507. Epub 2018 Nov 1.

Department of Community Health Behavior and Education, Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro, Georgia.

Objective: The study objective was to identify the perceptions of children with sickle cell disease (SCD) in the school environment.

Methods: Semistructured interviews (N = 14) were conducted with pediatric patients ages 6 to 10 who attended Metro Nashville Public Schools. These participants were recruited through the Vanderbilt Sickle Cell Disease Clinic. Read More

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November 2018
1 Read

Can Transcranial Direct-Current Stimulation Alone or Combined With Cognitive Training Be Used as a Clinical Intervention to Improve Cognitive Functioning in Persons With Mild Cognitive Impairment and Dementia? A Systematic Review and Meta-Analysis.

Front Hum Neurosci 2018 16;12:416. Epub 2018 Oct 16.

Department of Occupational Therapy, Monash University, Melbourne, VIC, Australia.

Transcranial direct-current stimulation (tDCS) facilitates cognitive improvement in healthy and pathological populations. It has been increasingly used in cases of mild cognitive impairment (MCI) and dementia. Our research question is: Can tDCS serve as a clinical intervention for improving the cognitive functions of persons with MCI (PwMCI) and dementia (PwD)? This systematic review evaluated the evidence to determine the efficacy of tDCS in improving cognitive outcomes in PwD and PwMCI. Read More

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October 2018
3 Reads

Chinese herbal medicines compared with N-acetylcysteine for the treatment of idiopathic pulmonary fibrosis: Protocol for a systematic review.

Medicine (Baltimore) 2018 Nov;97(44):e13077

Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan.

Background: Idiopathic pulmonary fibrosis (IPF) is a major public health problem worldwide. There is no curative treatment for IPF except lung transplantation. Chinese herbal medicines (CHMs) are widely used in the treatment of IPF in China. Read More

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November 2018
4 Reads

Chinese herbal medicine for dyslipidemia: protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2018 Nov;97(44):e13048

First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.

Background: Dyslipidemia is commonly characterized by the abnormal quantity and quality of lipids in plasma, which is strongly associated with an increased risk of cardiovascular disease and also a major cause of morbidity and even leads to mortality. In China and East Asia, Chinese herbal medicine has been widely used to treat diverse diseases for thousands of years. As an important means of traditional Chinese medicine treatment, Chinese herbal medicine plays a more important role in the treatment of dyslipidemia. Read More

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November 2018
4 Reads

Evaluation of the efficacy and safety of elemene in treating malignant pleural effusion caused by tumors: A PRISMA guided meta-analysis.

Medicine (Baltimore) 2018 Nov;97(44):e12542

Department of Cardiothoracic and Breast Surgery, Xiang Yang No. 1 People's Hospital, HuBei University of Medicine, XiangYang, Hubei, P.R. China.

Objective: Elemene is widely used to treat malignant pleural effusion in China. This meta-analysis aimed to evaluate the efficacy and safety of elemene in treating malignant pleural effusion.

Methods: Electronic databases including Pubmed, the Cochrane Library, Embase and Chinese biomedical literature database were searched until March 2017. Read More

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November 2018
2 Reads
5.723 Impact Factor

The positive aspects of attention deficit hyperactivity disorder: a qualitative investigation of successful adults with ADHD.

Atten Defic Hyperact Disord 2018 Oct 29. Epub 2018 Oct 29.

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.

The behavioural characteristics of ADHD do not exist in binary form (i.e. normal vs. Read More

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October 2018
8 Reads

Bringing Human Diversity into Design Processes Through Empathic Modelling.

Stud Health Technol Inform 2018 ;256:128-136

Certec, Department of Design Sciences, Lund University, Sweden.

Most products are developed while adapting to requirements from industrial production and logistics. To break that trend and design for people, we suggest focusing on those who put the strongest demands on the final solution. They cannot compensate for bad design solutions and are thereby, like sniffing dogs, guiding designers to meet peoples' needs. Read More

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January 2018
8 Reads

Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials.

J Am Heart Assoc 2018 Oct;7(19):e009835

2 China Heart Institute of Chinese Medicine China Academy of Chinese Medical Sciences Beijing China.

Background Previous studies have demonstrated a possible association between the induction of coenzyme Q10 (CoQ10) after statin treatment and statin-induced myopathy. However, whether CoQ10 supplementation ameliorates statin-induced myopathy remains unclear. Methods and Results PubMed, EMBASE , and Cochrane Library were searched to identify randomized controlled trials investigating the effect of CoQ10 on statin-induced myopathy. Read More

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October 2018
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[Meta-analysis on safety of application of enhanced recovery after surgery to laparoscopic bariatric surgery].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Oct;21(10):1167-1174

Department of General Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China.Email:

Objective: To systematically review the safety of application of enhanced recovery after surgery(ERAS) to laparoscopic bariatric surgery.

Methods: The randomized controlled trials (RCTs) or case-controlled trials concerning application of ERAS principles in bariatric surgery were collected by searching several national and international online databases, including PubMed, Cochrane Library, CNKI, EMBASE and Wanfang databases. Data collection was completed in October 2016. Read More

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October 2018
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