1,710 results match your criteria Hand-Foot-and-Mouth Disease


Epidemiological features and spatial clusters of hand, foot, and mouth disease in Qinghai Province, China, 2009-2015.

BMC Infect Dis 2018 Dec 5;18(1):624. Epub 2018 Dec 5.

Institute for Infectious Disease Control and Prevention, Qinghai Provincial Center for Disease Control and Prevention, Xining, Qinghai, China.

Background: Hand, Foot, and Mouth Disease (HFMD) is most frequently caused by Enterovirus71 (EV-A71) or Coxsackie virus A16 (CV-A16), infants and young children are at greatest risk. Describing the epidemiology of HFMD can help develop and better target interventions, including the use of pediatric EV-A71 vaccination.

Methods: We obtained data from the national surveillance system for HFMD cases with onset dates from 2009 to 2015. Read More

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December 2018
1 Read

A Simple Scoring System for Quick, Accurate, and Reliable Early Diagnosis of Hand, Foot, and Mouth Disease.

Med Sci Monit 2018 Nov 29;24:8627-8638. Epub 2018 Nov 29.

Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China (mainland).

BACKGROUND To construct an accurate, reliable, and simple scoring system of improving HFMD diagnosis. MATERIAL AND METHODS Based on the following 3 steps, a simple scoring diagnostic system was built: (1) we selected basic markers (age and sex), markers recommended in HFMD diagnosis guidelines, and significant biomarkers among severity groups found in a large dataset; (2) we used positive constituent ratio for determining scores of each marker; and (3) we applied receiving operating curve in an external dataset to determine the optimal cut-off score. RESULTS The selected markers were sex, age, fever, skin rashes, nervous system disorder, respiratory system disorder, digestive system disorder and cardiopulmonary complications, C-reactive-protein, White Blood Cell, Creatinine Kinase, Creatinine Kinase Isoenzyme, Gamma-Glutamyl Transpeptidase, Albumin, Globulin, Albumin/Globulin Ratio, Natrium, Chloride, Calcium, and Glucose. Read More

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November 2018
2 Reads

Immunocompetent and Immunodeficient Mouse Models for Enterovirus 71 Pathogenesis and Therapy.

Viruses 2018 Nov 28;10(12). Epub 2018 Nov 28.

Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.

Enterovirus 71 (EV71) is a global health threat. Children infected with EV71 could develop hand-foot-and-mouth disease (HFMD), encephalitis, paralysis, pulmonary edema, and death. At present, no effective treatment for EV71 is available. Read More

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November 2018

Structures of Coxsackievirus A10 unveil the molecular mechanisms of receptor binding and viral uncoating.

Nat Commun 2018 Nov 26;9(1):4985. Epub 2018 Nov 26.

National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

Coxsackievirus A10 (CVA10), a human type-A Enterovirus (HEV-A), can cause diseases ranging from hand-foot-and-mouth disease to polio-myelitis-like disease. CVA10, together with some other HEV-As, utilizing the molecule KREMEN1 as an entry receptor, constitutes a KREMEN1-dependent subgroup within HEV-As. Currently, there is no vaccine or antiviral therapy available for treating diseases caused by CVA10. Read More

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November 2018
3 Reads

Forecasting hand, foot, and mouth disease in Shenzhen based on daily level clinical data and multiple environmental factors.

Biosci Trends 2018 ;12(5):450-455

Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences.

Hand, foot, and mouth disease (HFMD) is caused by a group of enteroviruses. It infects millions of children in the Southeast Asian area. An accurate forecasting of outbreaks of HFMD could facilitate public health officials to suggest public health actions earlier. Read More

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January 2018
2 Reads

Severe atypical hand-foot-and-mouth disease in adults due to coxsackievirus A6: Clinical presentation and phylogenesis of CV-A6 strains.

J Clin Virol 2018 Nov 17;110:1-6. Epub 2018 Nov 17.

Clinical Microbiology, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.

Background: Typically, hand-foot-and-mouth disease (HFMD) is a mild childhood illness associated with coxsackievirus (CV)-A16, CV-A6, enterovirus (EV)-A71.

Objectives: To identify the viral agents associated with severe cases of atypical HFMD in Italy.

Study Design: Epidemiologically unrelated cases of severe atypical HFMD admitted to the Emergency Room (ER) of IRCCS San Martino IST (Genoa, Italy) in 2014-2016 were investigated. Read More

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November 2018
4 Reads

Acute Kidney Injury Secondary to Severe Hand, Foot and Mouth Disease Caused by Enterovirus-A71: Hypertension Is a Common.

J Trop Pediatr 2018 Nov 19. Epub 2018 Nov 19.

Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Hand, foot and mouth disease (HFMD) is a common infectious disease among children, caused primarily by human enterovirus-A71 (EV-A71) and coxsackievirus-A16 (CV-A16). To date, only two case reports mention that renal involvement can be secondary to or coexisting with CV-A16-associated HFMD. In the present report, we describe a 10-year-old girl who was infected with EV-A71 and subsequently developed a definite acute kidney injury (AKI), mainly based on the characteristic rash, virus isolation, eyelid edema, hypertension, decreased urine output, mild proteinuria and impaired renal function. Read More

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November 2018
1 Read

Severe enterovirus A71 associated hand, foot and mouth disease, Vietnam, 2018: preliminary report of an impending outbreak.

Euro Surveill 2018 Nov;23(46)

Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.

Since January 2018, over 53,000 hospitalisations and six deaths due to hand, foot and mouth disease (HFMD) have occurred across Vietnam with most cases from September onward. In a large tertiary referral hospital, Ho Chi Minh City, enterovirus A71 subgenogroup C4 was predominant, while B5 was only sporadically detected. The re-emergence of C4 after causing a severe HFMD outbreak with > 200 deaths in 2011-12 among susceptible young children raises concern of another impending severe outbreak. Read More

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November 2018
2 Reads

Meteorological factors and its association with hand, foot and mouth disease in Southeast and East Asia areas: a meta-analysis.

Epidemiol Infect 2018 Nov 19:1-18. Epub 2018 Nov 19.

Department of Epidemiology and Health Statistics,School of Public Health, Southeast University,Nanjing (210009),China.

Since the late 1990s, hand, foot and mouth disease (HFMD) has become a common health problem that mostly affects children and infants in Southeast and East Asia. Global climate change is considered to be one of the major risk factors for HFMD. This study aimed to assess the correlation between meteorological factors and HFMD in the Asia-Pacific region. Read More

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November 2018
2 Reads

Enterovirus-A71 Infection Activates Human Immune Responses and Induces Pathological Changes in Humanized Mice.

J Virol 2018 Nov 14. Epub 2018 Nov 14.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore

Since the discovery of enterovirus-A71 (EV-A71) half a century ago, it has caused large-scale outbreaks of hand-foot-and-mouth disease worldwide, in particular in the Asia-Pacific region, causing a great concern of public health and economic burden. Detailed mechanisms on the modulation of immune responses after EV-A71 infection have not been fully known, and the lack of appropriate models hinders the development of promising vaccines and drugs. In the present study, NOD- (NSG) mice with human immune system (humanized mice) at the age of four-week-old were found to be susceptible to a human isolate of EV-A71 infection. Read More

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November 2018
13 Reads

Hand, foot and mouth disease and herpangina caused by enterovirus A71 infections: a review of enterovirus A71 molecular epidemiology, pathogenesis, and current vaccine development.

Rev Inst Med Trop Sao Paulo 2018 Nov 8;60:e70. Epub 2018 Nov 8.

Tainan Municipal Hospital (Managed by Show Chwan Medical Care Corporation), Department of Occupational Medicine, Tainan, Taiwan.

Enterovirus A71 (EV-A71) infections are one of the main etiological agents of hand, foot and mouth disease (HFMD) and herpangina worldwide. EV-A71 infection is a life-threatening communicable disease and there is an urgent global need for the development of vaccines for its prevention and control. The morbidity rate of EV-A71 infection differs between countries. Read More

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November 2018
8 Reads

The gut microbiota of hand, foot and mouth disease patients demonstrates down-regulated butyrate-producing bacteria and up-regulated inflammation-inducing bacteria.

Acta Paediatr 2018 Nov 14. Epub 2018 Nov 14.

Department of Paediatrics, West China Second Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan University, Ministry of Education, No 20, 3rd section of Renmin South Road, Chengdu, 610041, China.

Aim: This study explored the gut microbiota of children with hand, foot and mouth disease (HFMD).

Methods: We enrolled 15 cases with HFMD admitted to the West China Second Hospital, Sichuan University, China, from July to September 2016 at a median age of three years. The controls were 15 healthy children of a similar age who underwent routine health examinations at the hospital during the same period. Read More

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November 2018
11 Reads

[Etiology and clinical analysis of central nervous system infection caused by Coxsackievirus B5 in severe hand, foot and mouth disease in Qingdao City, 2013-2014].

Zhonghua Yu Fang Yi Xue Za Zhi 2018 Nov;52(11):1168-1172

College of Public Health, Qingdao University, Qingdao 266021, China.

To illuminate the gene characteristics and clinical characterization of Coxsackievirus B5 (CV-B5) strains isolated from patients with sevre hand, foot and mouth disease (HFMD) in Qingdao city. A total of 1 844 patients of HFMD were consecutively admitted to Qingdao Women and Children's Hospital from 2013 to 2014. Information of the study population described above was collected retrospectively. Read More

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November 2018
4 Reads

Nationwide Survey of Pediatric Inpatients With Hand, Foot, and Mouth Disease, Herpangina, and Associated Complications During an Epidemic Period in Japan: Estimated Number of Hospitalized Patients and Factors Associated With Severe Cases.

J Epidemiol 2018 Nov 10. Epub 2018 Nov 10.

Department of Public Health, Osaka City University Graduate School of Medicine.

Background: Severe pediatric cases of hand, foot, and mouth disease (HFMD), herpangina (HA), and associated complications caused by enterovirus 71 (EV71) infection have brought substantial public health impact in Asia. This study aimed to elucidate the epidemiology of these pediatric cases in Japan.

Methods: A nationwide survey was conducted using stratified random sampling of hospital pediatric departments. Read More

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November 2018
1 Read

High-Throughput Sequencing of Putative Novel microRNAs in Rhesus Monkey Peripheral Blood Mononuclear Cells following EV71 and CA16 Infection.

Intervirology 2018 7;61(3):133-142. Epub 2018 Nov 7.

Objectives: Enterovirus 71 (EV71) and Coxsackievirus A16 (CA16) remain the major pathogens in hand, foot, and mouth disease (HFMD) cases, but the mechanisms of the different pathogeneses that follow EV71 and CA16 infection remain largely unknown.

Methods: Herein, we utilized microRNA (miRNA) deep sequencing to investigate the roles of novel differentially expressed miRNAs in peripheral blood mononuclear cells (PBMCs) infected with EV71 and CA16.

Results: The results identified 13 novel differentially expressed miRNAs in each group. Read More

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November 2018
11 Reads

Estimating the Severity Profile of Enterovirus A71 Infections in Children: A Bayesian Synthesis Framework.

Am J Epidemiol 2018 Oct 24. Epub 2018 Oct 24.

WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.

Enterovirus A71 (EV-A71) is responsible for the majority of severe hand- foot-and-mouth disease, but little evidence is available on the severity profile of EV-A71 infections. We formulated a hierarchical Bayesian model which synthesized data on EV-A71 associated diseases/events and EV-A71 antibody responses to infection among unvaccinated children from large clinical trials of EV-A71 vaccination which were conducted in Jiangsu and Beijing during 2012 and 2013, to reconstruct the severity profile in a unified framework. On average 15. Read More

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October 2018
5 Reads

Cloning and expression of enterovirus 71 capsid protein 1 in a probiotic Bifidobacterium pseudocatenulatum.

Lett Appl Microbiol 2018 Oct 24. Epub 2018 Oct 24.

College of Medicine and Public Health, Ubon Ratchathani University, Ubon Ratchathani, Thailand.

This study investigated cloning and expression of enterovirus 71 viral capsid protein 1 (EV71-VP1) in Bifidobacterium pseudocatenulatum (B. pseudocatenulatum) M115. To achieve this, a codon-optimized gene coding for EV71-VP1 was analysed, designed, synthesized and cloned into a plasmid vector flanked by a transcriptional promoter and terminator sequences. Read More

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October 2018
5 Reads

Association of polymorphisms in the vitamin D receptor gene with severity of hand, foot, and mouth disease caused by enterovirus 71.

J Med Virol 2018 Oct 24. Epub 2018 Oct 24.

Department of Infectious Diseases, Xi'an Jiaotong University Second Affiliated Hospital, Xi'an, China.

Severe hand, foot, and mouth disease (HFMD) is sometimes associated with critical complications that can cause substantial child mortality. Activity of the vitamin D receptor (VDR) may influence the outcomes of enterovirus 71 (EV71) infection. This case-control study aimed to assess the association of single-nucleotide polymorphisms (SNPs) in the gene encoding the VDR with the severity of EV71-associated HFMD. Read More

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October 2018
5 Reads

The Effect of School Closure on Hand, Foot, and Mouth Disease Transmission in Singapore: A Modeling Approach.

Am J Trop Med Hyg 2018 Oct 22. Epub 2018 Oct 22.

Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore.

Singapore implements school closure policy for institutional hand, foot, and mouth disease (HFMD) outbreaks, but there is a lack of empirical evidence on the effect of closure on HFMD transmission. We conducted a retrospective analysis of 197,207 cases of HFMD over the period 2003-2012 at the national level and of 57,502 cases in 10,080 institutional outbreaks over the period 2011-2016 in Singapore. The effects of school closure due to 1) institutional outbreaks, 2) public holidays, and 3) school vacations were assessed using a Bayesian time series modeling approach. Read More

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October 2018
2 Reads

Seroprevalence of antibodies to enterovirus 71 and coxsackievirus A16 among people of various age groups in a northeast province of Thailand.

Virol J 2018 10 16;15(1):158. Epub 2018 Oct 16.

Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Nakhon Pathom, 73170, Thailand.

Background: Hand, foot and mouth disease (HFMD) is endemic among population of young children in Thailand. The disease is mostly caused by enterovirus 71 (EV71) and coxsackievirus A16 (CA16).

Methods: This study conducted serosurveillance for neutralizing (NT) antibodies to EV71 subgenotypes B5 and C4a, and to CA16 subgenotypes B1a and B1b, in 579 subjects of various ages using a microneutralization assay in human rhabdomyosarcoma (RD) cells. Read More

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October 2018
2 Reads
2.180 Impact Factor

Analysis of an Imported Subgenotype C2 Strain of Human Enterovirus 71 in Beijing, China, 2015.

Front Microbiol 2018 28;9:2337. Epub 2018 Sep 28.

Beijing Center for Disease Prevention and Control, Beijing, China.

Subgenotype C4 of enterovirus 71 (EV71) is the predominant agent of Hand Foot and Mouth disease (HFMD) circulating in the mainland of China. For the first time, a subgenotype C2 of EV71 named SY30-2 was isolated from a HFMD case in Beijing, China. Since it is uncertain whether antibodies raised against subgenotype C4 of EV71 can protect C2 EV71, it is important to monitor and check the presence of cross-reactive antibodies against new EV71 subgenotypes. Read More

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September 2018
8 Reads
3.940 Impact Factor

Epidemiological Features of Hand, Foot and Mouth Disease Outbreaks among Chinese Preschool Children: A Meta-analysis.

Iran J Public Health 2018 Sep;47(9):1234-1243

Dept. of Public Health, Xuhui Central Hospital, Shanghai, China.

Background: Hand-foot-mouth disease (HFMD) is a widespread communicable disease and has caused large epidemics in many countries. This meta-analysis aimed to analyze and evaluate the epidemiological features of HFMD outbreaks in Chinese preschools.

Methods: Literature review was based on PubMed, Chinese National Knowledge Infrastructure (CNKI) and Wanfang databases from 2008 to 2015. Read More

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September 2018

Bayesian spatiotemporal analysis for association of environmental factors with hand, foot, and mouth disease in Guangdong, China.

Sci Rep 2018 Oct 11;8(1):15147. Epub 2018 Oct 11.

Department of Medical Statistics and Epidemiology & Health Information Research Center & Guangdong Key Laboratory of Medicine, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China.

Hand, foot, and mouth disease (HFMD) remains a significant public health and economic burden in parts of China, particularly Guangdong Province. Although the association between meteorological factors and HFMD has been well documented, significant gaps remain in our understanding of the potential impact of environmental factors. Using county-level monthly HFMD data from China CDC and environmental data from multiple sources, we used spatiotemporal Bayesian models to evaluate the association between HFMD and environmental factors including vegetation index, proportion of artificial surface, road capacity, temperature and humidity, and assessed the spatial and temporal dynamic of the association. Read More

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October 2018
1 Read

Non-clinical safety assessment of repeated intramuscular administration of an EV-A71 VLP vaccine in rabbits.

Vaccine 2018 Oct 4;36(45):6623-6630. Epub 2018 Oct 4.

Sentinext Therapeutics, Suite 12A, Level 12, Menara Northam, 55, Jalan Sultan Ahmad Shah, 10050 George Town, Pulau Pinang, Malaysia.

A candidate hand, foot, and mouth disease vaccine comprising of human enterovirus A71 (EV-A71) virus-like particles (VLPs) was tested in rabbits to evaluate the potential local and systemic effects of this vaccine. The rabbits received more than double the full human dose and one additional dose according to the n + 1 recommended scheme. The three doses were given mixed with Alhydrogel adjuvant as intramuscular (IM) injections. Read More

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October 2018
5 Reads

Chinese guidelines for the diagnosis and treatment of hand, foot and mouth disease (2018 edition).

World J Pediatr 2018 Oct 3;14(5):437-447. Epub 2018 Oct 3.

Department of Pediatrics, Yan'an Hospital of Kunming City, Kunming, China.

Background: Hand, foot, and mouth disease (HFMD) is a common infectious disease in childhood caused by an enterovirus (EV), and which is principally seen in children under 5 years of age. To promote diagnostic awareness and effective treatments, to further standardize and strengthen the clinical management and to reduce the mortality of HFMD, the guidelines for diagnosis and treatment have been developed.

Methods: National Health Commission of China assembled an expert committee for a revision of the guidelines. Read More

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October 2018
7 Reads

Enhanced neutralizing antibody response induced by inactivated enterovirus 71 in cynomolgus monkeys.

PLoS One 2018 2;13(10):e0202552. Epub 2018 Oct 2.

Division of Vaccine Research, National Research Institute of Health, Centers for Disease Control and Prevention, Osong-eup, CheongJu, Chungcheongbuk-do, Republic of Korea.

Enterovirus 71 (EV71) is a major etiological agent of various public health issues, particularly in the Asia-Pacific region. EV71 causes hand-foot-and-mouth disease (HFMD) and is associated with serious neurological disorders in young children. A formalin-inactivated EV71 candidate vaccine (KCDC-HFMDV1-EV71) based on the C4 subgenotype was previously developed and confirmed to be a potential candidate vaccine for prevention of EV71 infection in mice. Read More

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October 2018
6 Reads

Atypical hand, foot, and mouth disease caused by Coxsackievirus A6 in Argentina in 2015.

Rev Argent Microbiol 2018 Sep 27. Epub 2018 Sep 27.

Servicio de Neurovirosis, INEI-ANLIS Dr. Carlos G. Malbran, Ciudad Autónoma de Buenos Aires, Argentina.

We present two groups of cases of atypical hand, foot, and mouth disease (HFMD) caused by Coxsackievirus A6 (CV-A6) detected in Argentina in 2015. The first group involved 14 patients from Chubut province and the second group affected 12 patients from San Luis province. Molecular analysis of the complete VP1 protein gene revealed the circulation of E2 sublineage, the most predominant worldwide. Read More

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September 2018
2 Reads

Molecular epidemiology of coxsackievirus A6 circulating in Hong Kong reveals common neurological manifestations and emergence of novel recombinant groups.

J Clin Virol 2018 Nov 8;108:43-49. Epub 2018 Sep 8.

Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China; Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, The University of Hong Kong, Hong Kong, China; Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Background: Coxsackievirus A6 (CV-A6) represents the predominant enterovirus serotype in Hong Kong, but its epidemiology in our population was unknown.

Objectives: To examine the clinical and molecular epidemiology of CV-A6 and detect emerging recombinant strains in Hong Kong.

Study Design: Nasopharyngeal aspirates (NPAs) from patients with febrile or respiratory illness were subject to RT-PCR for CV-A6 and sequencing of 5'-NCR and VP1. Read More

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November 2018
2 Reads

Epidemiological characteristics and influential factors of hand, foot, and mouth disease reinfection in Wuxi, China, 2008-2016.

BMC Infect Dis 2018 Sep 19;18(1):472. Epub 2018 Sep 19.

Wuxi Center for Disease Control and Prevention, Wuxi, 214023, Jiangsu, China.

Background: Hand, foot, and mouth disease (HFMD) is a viral disease caused by human enteroviruses. Although HFMD reinfection is common, studies investigating this phenomenon are insufficient.

Methods: The present study focused on HFMD reinfection in Wuxi from 2008 to 2016 using surveillance system data. Read More

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September 2018
1 Read

Emerging Enteroviruses Causing Hand, Foot and Mouth Disease, China, 2010-2016.

Emerg Infect Dis 2018 Oct;24(10):1902-1906

Coxsackievirus A6 emerged as one of the predominant causative agents of hand, foot and mouth disease epidemics in many provinces of China in 2013 and 2015. This virus strain accounted for 25.9% of mild and 15. Read More

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October 2018
33 Reads
6.750 Impact Factor

Epidemic dynamics, interactions and predictability of enteroviruses associated with hand, foot and mouth disease in Japan.

J R Soc Interface 2018 Sep 12;15(146). Epub 2018 Sep 12.

Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA

Outbreaks of hand, foot and mouth disease have been documented in Japan since 1963. This disease is primarily caused by the two closely related serotypes of Enterovirus A71 (EV-A71) and Coxsackievirus A16 (CV-A16). Here, we analyse Japanese virologic and syndromic surveillance time-series data from 1982 to 2015. Read More

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September 2018
1 Read

Temporal relationship between occurrences of hand, foot and mouth disease, respiratory virus detection and febrile seizures in children in tropical Singapore: a time-series analysis.

Epidemiol Infect 2018 Sep 13:1-6. Epub 2018 Sep 13.

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System,Singapore,Singapore.

Febrile seizure (FS) in children is a common complication of infections with respiratory viruses and hand, foot and mouth disease (HFMD). We conducted a retrospective ecological time-series analysis to determine the temporal relationship between hospital attendances for FS and HFMD or respiratory virus infections. Epilepsy attendance was used as a control. Read More

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September 2018
6 Reads

Establishment of normal reference values of NT-proBNP and its application in diagnosing acute heart failure in children with severe hand food and mouth disease.

Medicine (Baltimore) 2018 Sep;97(36):e12218

School Of Basic Medical Science, Central South University.

Hand, foot, and mouth disease (HFMD), caused by enteroviruses, is an acute contagious disease in children. Some severe infections caused by human enterovirus 71 (HEV71) lead to rapid death in children with acute heart failure (HF). N-terminal probrain natriuretic peptide (NT-proBNP) is an important indicator of HF; however, its normal reference values in children and role in HFMD remain unclear. Read More

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September 2018
1 Read

Serum-derived IgG from coxsackievirus A6-infected patients can enhance the infection of peripheral blood mononuclear cells with coxsackievirus A6.

Microb Pathog 2018 Dec 4;125:7-11. Epub 2018 Sep 4.

Univ Lille Faculté de Médecine, CHU Lille Laboratoire de Virologie EA3610, F-59037, Lille, France. Electronic address:

Coxsackievirus A6 (CV-A6) has recently emerged as an enterovirus causing Hand Foot and Mouth Disease with severe complications. The pathogenic mechanisms of CV-A6- associated Hand foot and Mouth disease are largely unknown. In this study, it was investigated whether serum and IgG from patients with CV-A6 infection can enhance the infection of PBMC with the virus. Read More

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December 2018
2 Reads

The emerging sub-genotype C2 of CoxsackievirusA10 Associated with Hand, Foot and Mouth Disease extensively circulating in mainland of China.

Sci Rep 2018 Sep 6;8(1):13357. Epub 2018 Sep 6.

Ministry of Health Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.

Coxsackievirus A10 (CV-A10) associated with Hand, foot, and mouth disease (HFMD) cases emerged increasingly in recent years. In this study, the samples from nation-wide HFMD surveillance, including 27 out of 31 provinces in China were investigated, and the continuous and extensive virological surveillance, covered 13 years, were conducted to provide a comprehensive molecular characterization analysis of CV-A10. 855 CV-A10 viruses (33 severe cases included), were isolated from HFMD children patients during 2009 to 2016 in China. Read More

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September 2018
1 Read
5.080 Impact Factor

Temperature and humidity affect the incidence of hand, foot, and mouth disease: a systematic review of the literature - a report from the International Society of Dermatology Climate Change Committee.

Int J Dermatol 2018 Sep 5. Epub 2018 Sep 5.

Department of Dermato-Venereology, Aarhus University Hospital, Aarhus, Denmark.

Hand, foot, and mouth disease (HFMD) is an enterovirus-mediated condition that predominantly affects children under 5 years of age. The tendency for outbreaks to peak in warmer summer months suggests a relationship between HFMD and weather patterns. We reviewed the English-language literature for articles describing a relationship between meteorological variables and HFMD. Read More

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September 2018
1 Read

Genetic characteristics of the P1 coding region of Coxsackievirus A16 associated with hand, foot, and mouth disease in China.

Mol Biol Rep 2018 Sep 4. Epub 2018 Sep 4.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases; The First Affiliated Hospital, College of Medicine, Zhejiang University; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 79 Qingchun Road, Hangzhou, 310003, China.

Coxsackievirus A16 (CVA16) is one of the major etiological agents of hand, foot, and mouth disease (HFMD) in young children. To investigate the genetic characteristics of the P1 coding region gene of CVA16 associated with HFMD in China, we included the sequences of CVA16 specimens obtained from outbreak investigations and sporadic HFMD cases between 1998 and 2014 in China from GenBank, we genotyped the CVA16 sequences and analyzed P1 coding region sequences that encode structural proteins with bioinformatics software. CVA16 was classified into genotypes A and B1 based on the VP1 gene; the B1b and B1a subgenotypes were the major CVA16 strains and predominated in the coastal areas of China. Read More

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September 2018
1 Read

Sex differences in common childhood infections in Taiwan.

Int J Infect Dis 2018 Oct 28;75:115-117. Epub 2018 Aug 28.

Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan; Department of Public Health, National Taiwan University College of Public Health, Taipei, Taiwan; Department of Environmental and Occupational Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan.

Sex differences in childhood infections are commonly reported in case-only studies. In this population-based study of 278000 Taiwanese children followed from 3 months to 18 years of age during the period 2000-2012, age-trajectories of monthly numbers of all-cause healthcare visits and monthly rates of infection-specific healthcare visits were compared between boys and girls. For all-cause healthcare visits and for healthcare visits related to conjunctivitis, respiratory tract infections, enteritis, hand, foot, and mouth disease, and herpangina, there was good resemblance of age trajectories between boys and girls. Read More

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October 2018
2 Reads

Molecular characterization of Coxsackievirus A16 strains isolated from children with severe hand, foot, and mouth disease in Yunnan, Southwest China, during 2009-2015.

J Med Virol 2019 Jan 9;91(1):155-160. Epub 2018 Oct 9.

The Department of Medical Genetics, Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming, China.

Coxsackievirus A16 (CV-A16) commonly causes mild symptoms, but severe diseases, such as aseptic meningitis, encephalitis, and even fatal cases, have been reported. Thirteen CV-A16 strains were isolated from patients with severe hand, foot, and mouth disease in Yunnan, Southwest China, from 2009 to 2015. Subgenotype B1a and B1b of CV-A16 were predominantly circulating the region with B1b the predominant strain in recent years. Read More

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January 2019
7 Reads

Hand, foot and mouth disease as an emerging public health problem: Case report of familial child-to-adult transmission.

Dent Med Probl 2018 Jan-Mar;55(1):99-104

Department of Gerodontology and Oral Pathology, Poznan University of Medical Sciences, Poland.

Hand, foot and mouth disease (HFMD) is a highly contagious viral infectious disease that commonly affects small children. Typical clinical symptoms include low-grade fever, malaise and myalgia followed by a characteristic maculovesicular eruption on hands, feet and the oral cavity. In most cases, the disease is self-limiting, but some severe complications, including pneumonia, meningitis and encephalitis, may occasionally occur. Read More

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August 2018
10 Reads

Enteroviruses associated with hand, foot, and mouth disease in Brazil.

J Infect 2018 Nov 24;77(5):448-454. Epub 2018 Aug 24.

Laboratório de Enterovírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. Electronic address:

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November 2018
9 Reads

A hand hygiene intervention to decrease hand, foot and mouth disease and absence due to sickness among kindergarteners in China: A cluster-randomized controlled trial.

J Infect 2018 Aug 19. Epub 2018 Aug 19.

Erasmus MC, University Medical Centre Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.

Objectives: To evaluate the effect of the "Clean Hands, Happy Life" intervention on the incidence of hand, food and mouth disease (HFMD) and on school absences due to sickness in kindergarten students.

Methods: The intervention consisted of four hand hygiene (HH) promotion components and was evaluated in a cluster-randomized controlled trial among 8275 children and 18 kindergartens from May to October, 2015 in Shenzhen, China. We compared two intervention arms - received the intervention in kindergartens only and in both kindergartens and families, respectively - to the control arm in multilevel analyses. Read More

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August 2018
7 Reads

Emergence of Coxsackie A6 hand-foot-and-mouth disease and comparative severity of Coxsackie B vs. echovirus infections, 2014-2016, UK.

J Infect 2018 Aug 19. Epub 2018 Aug 19.

Clinical Microbiology and Virology, UHL, Leicester, UK; Infection, Immunity and Inflammation, University of Leicester, Leicester, UK. Electronic address:

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August 2018
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Molecular epidemiology analysis of enterovirus 71 strains isolated in Dak Lak, Vietnam, 2011-2016.

J Med Virol 2019 Jan 24;91(1):56-64. Epub 2018 Sep 24.

Department of Epidemiology, Tay Nguyen Institute of Hygiene and Epidemiology, Buon Ma Thuot, Vietnam.

Human enterovirus 71 (EV71) is the major etiologic agent of hand, foot, and mouth disease (HFMD). EV71 outbreaks have been reported in Dak Lak in recent years, however, the genotypes/subgenotypes information and phylogeny of circulating EV71 strains are limited. The objectives of this study were to determine the genotypes/subgenotypes and investigate the phylogeny of EV71 isolates in Dak Lak over a 6-year period. Read More

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January 2019
6 Reads

An outbreak of Coxsackievirus A6-associated hand, foot, and mouth disease in a kindergarten in Beijing in 2015.

BMC Pediatr 2018 Aug 21;18(1):277. Epub 2018 Aug 21.

Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, No. 10 Xitoutiao, You'anmen Wai, Fengtai District, Beijing, 100069, People's Republic of China.

Background: Coxsackievirus A6 (CVA6) is one of the major agents to cause hand, foot and mouth disease (HFMD) outbreaks globally. The objective of this study is to investigate the epidemiologic and clinical manifestations of CVA6 outbreak, and thus guide the diagnosis and treatment of the disease, as well as disease prevention.

Methods: An HFMD outbreak in a kindergarten was reported to Shijingshan District Center for Disease Control and Prevention (SCDC) on November 2, 2015 in Beijing, China. Read More

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August 2018
1 Read
1.920 Impact Factor

Polymorphism of OAS2 rs739901 C/A Involves the Susceptibility to EV71 Infection in Chinese Children.

Curr Med Sci 2018 Aug 20;38(4):640-647. Epub 2018 Aug 20.

Department of Pediatrics, the Affiliated Hospital of Qingdao University, Qirtgdao, 266000, China.

This study aimed to assess the relationship of OAS2 rs739901 5,-flanking C/A polymorphisms with the susceptibility to Enterovirus-71 (EV71) infection. We investigated 294 hand-foot-mouth disease (HFMD) Chinese children with EV71 infection (165 mild cases and 129 encephalitis cases). The improved multiplex ligation detection reaction (iMLDR) technique was used to test the genotypes. Read More

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August 2018
12 Reads

You're the Flight Surgeon.

Authors:

Aerosp Med Hum Perform 2018 Sep;89(9):851-853

Netters TA Jr. You're the flight surgeon: chest discomfort in a flyer. Aerosp Med Hum Perform. Read More

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September 2018

T Cell Immunity To Enterovirus 71 Infection In Humans And Implications For Vaccine Development.

Int J Med Sci 2018 25;15(11):1143-1152. Epub 2018 Jul 25.

Centre for Virus and Vaccine Research, School of Science and Technology, Sunway University, Bandar Sunway, Kuala Lumpur, Selangor 47500, Malaysia.

Enterovirus 71 (EV-A71) is one of the major pathogens causing hand, foot and mouth disease (HFMD). Some strains can lead to neurological disease and fatality in children. Up to date, there is no FDA-approved vaccine to prevent severe HFMD and mortality. Read More

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July 2018
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Exploring spatiotemporal nonstationary effects of climate factors on hand, foot, and mouth disease using Bayesian Spatiotemporally Varying Coefficients (STVC) model in Sichuan, China.

Sci Total Environ 2019 Jan 9;648:550-560. Epub 2018 Aug 9.

State Key Laboratory of Resources and Environmental Information System (LREIS), Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China.

Background: Pediatric hand, foot, and mouth disease (HFMD) has generally been found to be associated with climate. However, knowledge about how this association varies spatiotemporally is very limited, especially when considering the influence of local socioeconomic conditions. This study aims to identify multi-sourced HFMD environmental factors and further quantify the spatiotemporal nonstationary effects of various climate factors on HFMD occurrence. Read More

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January 2019
5 Reads
4.100 Impact Factor