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    2116 results match your criteria Hand-Foot-and-Mouth Disease

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    Artemisia capillaris inhibited enterovirus 71-induced cell injury by preventing viral internalization.
    Kaohsiung J Med Sci 2018 Mar 6;34(3):150-159. Epub 2017 Dec 6.
    Department of Renal Care, College of Medicine, Kaohsiung Medical University, Taiwan; Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan. Electronic address:
    Artemisia capillaris (A. capillaris) is a common herbal drug used for thousands years in ancient China. A. Read More

    Comprehensive virome analysis reveals the complexity and diversity of the viral spectrum in pediatric patients diagnosed with severe and mild hand-foot-and-mouth disease.
    Virology 2018 Feb 19;518:116-125. Epub 2018 Feb 19.
    Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. Electronic address:
    The management of hand-foot-and-mouth disease(HFMD) epidemic is difficult due to the frequent emergence of non-EV71 and non-CVA16 enteroviruses and some cases testing negative for HFMD-associated causative agents. To clarify the virus spectrum of mild and severe HFMD, a comprehensive virome analysis of 238 samples was performed using next-generation sequencing (NGS). The data revealed total thirteen mammalian- and plant- virus families and diverse viral populations including enteroviruses, common respiratory viruses, diarrhea-related viruses, plant viruses and anelloviruses. Read More

    A virus-like particle vaccine protects mice against coxsackievirus A10 lethal infection.
    Antiviral Res 2018 Feb 19. Epub 2018 Feb 19.
    Unit of Vaccinology & Antiviral Strategies, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China; Joint Center for Infection and Immunity, Guangzhou Institute of Pediatrics, Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China. Electronic address:
    Coxsackievirus A10 (CVA10) has emerged worldwide as one of the main pathogens of hand, foot, and mouth disease (HFMD) in recent years. However, there is currently no commercial vaccine available to prevent CVA10 infection. Here we report the development of a recombinant virus-like particle (VLP) based candidate vaccine for CVA10. Read More

    Infantile bullous pemphigoid with "string of pearls sign".
    Dermatol Online J 2017 Jul 15;23(7). Epub 2017 Jul 15.
    Department of Dermatology, Centro Hospitalar do Porto, Portugal.
    Bullous pemphigoid (BP) is an immune mediated bullous disease that is manifested by urticarial plaques with superimposed subepidermal blisters and significant pruritus. It is generally found in the elderly, but is rare in the pediatric population. A 5-month-old girl previously diagnosed with hand-foot-mouth disease was examined in our dermatology department owing to vesicles and bullae, initially located to the hands and feet, which progressed with new lesions. Read More

    Fibronectin facilitates EV71 infection by mediating its entry.
    J Virol 2018 Feb 21. Epub 2018 Feb 21.
    The State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
    Fibronectin (FN) is a high molecular weight extracellular matrix protein that contains RGDS motif, which is required to bind to integrins. Synthetic RGDS peptides have been reported to compete with FN to bind to the cell surface and inhibit the function of FN. Here, we identified that synthetic RGDS peptides significantly inhibit human enterovirus 71 (EV71) infection in cell cultures. Read More

    A spatiotemporal mixed model to assess the influence of environmental and socioeconomic factors on the incidence of hand, foot and mouth disease.
    BMC Public Health 2018 Feb 20;18(1):274. Epub 2018 Feb 20.
    LREIS, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, China.
    Background: As a common infectious disease, hand, foot and mouth disease (HFMD) is affected by multiple environmental and socioeconomic factors, and its pathogenesis is complex. Furthermore, the transmission of HFMD is characterized by strong spatial clustering and autocorrelation, and the classical statistical approach may be biased without consideration of spatial autocorrelation. In this paper, we propose to embed spatial characteristics into a spatiotemporal additive model to improve HFMD incidence assessment. Read More

    Epidemiology of Recurrent Hand, Foot and Mouth Disease, China, 2008-2015.
    Emerg Infect Dis 2018 Mar;24(3)
    Using China's national surveillance data on hand, foot and mouth disease (HFMD) for 2008-2015, we described the epidemiologic and virologic features of recurrent HFMD. A total of 398,010 patients had HFMD recurrence; 1,767 patients had 1,814 cases of recurrent laboratory-confirmed HFMD: 99 reinfections of enterovirus A71 (EV-A71) with EV-A71, 45 of coxsackievirus A16 (CV-A16) with CV-A16, 364 of other enteroviruses with other enteroviruses, 383 of EV-A71 with CV-A16 and CV-A16 with EV-A71, and 923 of EV-A71 or CV-A16 with other enteroviruses and other enteroviruses with EV-A71 or CV-A16. The probability of HFMD recurrence was 1. Read More

    Honeysuckle-encoded microRNA2911 inhibits Enterovirus 71 replication via targeting VP1 gene.
    Antiviral Res 2018 Feb 16. Epub 2018 Feb 16.
    Central Laboratory, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China. Electronic address:
    Enterovirus 71 (EV71) is the primary pathogen of hand-foot-and-mouth disease (HFMD) in children and virus infections are associated with severe neurological dysfunctions and even death. MIR2911 is a honeysuckle-encoded atypical microRNA with extremely stability. Here, we report that MIR2911 directly inhibits EV71 replication by targeting the VP1 gene. Read More

    Identification and characterization of neutralization epitopes at VP2 and VP1 of enterovirus A71.
    J Med Virol 2018 Feb 19. Epub 2018 Feb 19.
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
    Enterovirus A71 (EV-A71) neutralization escape mutants were generated with monoclonal antibody MAB979 (Millipore). The VP2-T141I and VP1-D14N substitutions were identified. Using reverse genetics, infectious clones with these substitutions were constructed and tested by neutralization assay with immune sera from mice and humans. Read More

    Profiling of novel microRNAs elicited by EV71 and CA16 infection in human bronchial epithelial cells using high-throughput sequencing.
    Virus Res 2018 Feb 13;247:111-119. Epub 2018 Feb 13.
    Yunnan Key Laboratory of Vaccine Research & Development on Severe Infections Disease, Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Kunming, 650118, China. Electronic address:
    Enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are two major etiologic agents associated with hand, foot, and mouth disease (HFMD) worldwide. Despite that they both belong to the Enterovirus genus of the Picornaviridae family, there are many differences in the infection process of these viruses. However, the underlying mechanisms have not been elucidated. Read More

    Pyroptosis induced by enterovirus 71 and coxsackievirus B3 infection affects viral replication and host response.
    Sci Rep 2018 Feb 13;8(1):2887. Epub 2018 Feb 13.
    Department of Microbiology, Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.
    Enterovirus 71 (EV71) is the primary causative pathogen of hand, foot, and mouth disease (HFMD), affecting children with severe neurological complications. Pyroptosis is a programmed cell death characterized by cell lysis and inflammatory response. Although proinflammatory response has been implicated to play important roles in EV71-caused diseases, the involvement of pyroptosis in the pathogenesis of EV71 is poorly defined. Read More

    [Hand-Foot-and-Mouth Disease, Aseptic Meningitis, and Encephalitis Caused by Enterovirus].
    Brain Nerve 2018 Feb;70(2):121-131
    Infectious Disease Surveillance Center, National Institute of Infectious Diseases.
    Enterovirus A71 (EV-A71), coxsackievirus A16 (CV-A16), and CV-A6 are the major causative agents of Hand-foot-and-mouth disease (HFMD). These viruses belong to the species Enterovirus A of the genus Enterovirus of the family Picornaviridae. These viruses can also cause aseptic meningitis (AM), encephalitis and/or paralysis. Read More

    Development of a reverse transcription recombinase-aided amplification assay for the detection of coxsackievirus A10 and coxsackievirus A6 RNA.
    Arch Virol 2018 Feb 10. Epub 2018 Feb 10.
    Key Laboratory for Medical Virology, National Health and Family Planning Commission, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, No. 155, Changbai Street, Changping District, Beijing, 102206, China.
    Hand, foot and mouth disease (HFMD) is a serious public health problem, and coxsackievirus A6 (CVA6) and coxsackievirus A10 (CVA10) are two of the major causative pathogens, in addition to enterovirus 71 (EV71) and coxsackievirus A16 (CVA16). A simple and rapid reverse transcription recombinase-aided amplification assay (RT-RAA) was developed for the detection of CVA10 and CVA6 in this study. The analytical sensitivity for detection of CVA10 and CVA6 at 95% probability by probit regression analysis was 35 copies per reaction and 38 copies per reaction, respectively, with 100% specificity. Read More

    GS-9620 inhibits enterovirus 71 replication mainly through the NF-κB and PI3K-AKT signaling pathways.
    Antiviral Res 2018 Feb 6. Epub 2018 Feb 6.
    Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Centre, Peking Union Medical Collage (PUMC) & Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Key Laboratory of Human Disease Comparative Medicine Ministry of Health, Beijing, PR China. Electronic address:
    Human enterovirus 71 (EV71) is the second most common cause of hand, foot, and mouth disease (HFMD), which can occur as a severe epidemic especially among children under 5-years old. New and improved treatment strategies to control EV71 infection are therefore urgently required. The heterocyclic compound GS-9620, a potent and selective agonist of Toll-like receptor 7 (TLR7), has been reported to activate plasmacytoid dendritic cells (pDCs), and suppress HBV as well as HIV replication. Read More

    Hand, foot and mouth disease: current knowledge on clinical manifestations, epidemiology, aetiology and prevention.
    Eur J Clin Microbiol Infect Dis 2018 Mar 6;37(3):391-398. Epub 2018 Feb 6.
    Università degli Studi di Milano, Milan, Italy.
    For a long time, hand, foot and mouth disease (HFMD) was seen as a mild viral infection characterized by typical clinical manifestations that spontaneously resolved in a few days without complications. In the past two decades, HFMD has received new attention because of evidence that this disease could have clinical, epidemiological and aetiological characteristics quite different from those initially thought. In contrast to previous beliefs, it has been clarified that HFMD can be associated with complications, leading to severe neurological sequelae and, rarely, to death. Read More

    Epidemiological Characteristics and Spatial-Temporal Distribution of Hand, Foot, and Mouth Disease in Chongqing, China, 2009-2016.
    Int J Environ Res Public Health 2018 Feb 5;15(2). Epub 2018 Feb 5.
    Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, No. 27, Nanwei Road, Xicheng District, Beijing 100050, China.
    (1): Even with licensed vaccine for enterovirus 71 (EV71) put into market in 2016 in China, hand, foot, and mouth disease (HFMD) is still a threat for children's health in Chongqing. We described the epidemiological characteristics and spatial-temporal patterns of HFMD in Chongqing from 2009 to 2016, in order to provide information and evidence for guiding public health response and intervention. (2): We retrieved the HFMD surveillance data from January 2009 to December 2016 from "National Disease Reporting Information System", and then analyzed demographic and geographical information integrally. Read More

    Impact of meteorological factors on the incidence of childhood hand, foot, and mouth disease (HFMD) analyzed by DLNMs-based time series approach.
    Infect Dis Poverty 2018 Jan 31;7(1). Epub 2018 Jan 31.
    Department of Epidemiology and Biostatistics, School of Public Health, Fudan University, Shanghai, 200032, China.
    Background: Hand, foot, and mouth disease (HFMD) has become an emerging infectious disease in China in the last decade. There has been evidence that meteorological factors can influence the HFMD incidence, and understanding the mechanisms can help prevent and control HFMD.

    Methods: HFMD incidence data and meteorological data in Minhang District, Shanghai were obtained for the period between 2009 and 2015. Read More

    Quantifying the influence of temperature on hand, foot and mouth disease incidence in Wuhan, Central China.
    Sci Rep 2018 Jan 31;8(1):1934. Epub 2018 Jan 31.
    Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical college, Huazhong University of Science and Technology, Wuhan, China.
    Hand, foot and mouth disease (HFMD) is a substantial burden throughout Asia, but the effects of temperature pattern on HFMD risk are inconsistent. To quantify the effect of temperature on HFMD incidence, Wuhan was chosen as the study site because of its high temperature variability and high HFMD incidence. Daily series of HFMD counts and meteorological variables during 2010-2015 were obtained. Read More

    Parental perspectives on hand, foot, and mouth disease among children in Hong Kong: a longitudinal study.
    Epidemiol Infect 2018 Feb 1;146(3):324-332. Epub 2018 Feb 1.
    Division of Behavioural Sciences,School of Public Health,The University of Hong Kong,Hong Kong,China.
    Hand, foot, and mouth disease (HFMD), usually a self-limiting illness for young children, could cause a significant burden for parents because it can take up to 1-2 weeks for a sick child to recover. We conducted a two-wave longitudinal study over one summer peak season (May-July 2014) of HFMD to examine parents' HFMD-related risk perceptions and protective responses. In total, 618 parents with at least one child aged ⩽12 years, recruited using randomly-dialled household telephone calls completed the baseline survey interview, 452 of whom subsequently completed the follow-up survey. Read More

    Cerebrospinal fluid chemokine patterns in children with enterovirus 71-related encephalitis.
    Sci Rep 2018 Jan 26;8(1):1658. Epub 2018 Jan 26.
    Department of Pulmonology, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, China.
    Enterovirus 71 (EV71) is a major pathogen that causes hand, foot and mouth disease (HFMD) as well as neurological complications, such as encephalitis. The chemokines involved in the migration of leukocytes have increasingly been implicated in infectious diseases of the central nervous system. Few studies have evaluated the levels of chemokines in HMFD children with EV71-related encephalitis. Read More

    Full-Genome Sequence of an Enterovirus 71 Strain Isolated from a Throat Swab from a Child with Severe Hand-Foot-and-Mouth Disease in Changzhou, China, in 2017.
    Genome Announc 2018 Jan 25;6(4). Epub 2018 Jan 25.
    Inspection Department, Changzhou Center for Disease Prevention and Control, Changzhou, Jiangsu, People's Republic of China.
    The full-length genome sequence of a human enterovirus 71 (EV71) strain (EV71/CZTN01/CHN/2017) was isolated from a throat swab from a child in Changzhou, China, in 2017. According to the phylogenetic analyses, the full-genome sequence in this study belongs to sub-subgenotype C4a. Read More

    Inhibition of EV71 by curcumin in intestinal epithelial cells.
    PLoS One 2018 25;13(1):e0191617. Epub 2018 Jan 25.
    Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan.
    EV71 is a positive-sense single-stranded RNA virus that belongs to the Picornaviridae family. EV71 infection may cause various symptoms ranging from hand-foot-and-mouth disease to neurological pathological conditions such as aseptic meningitis, ataxia, and acute transverse myelitis. There is currently no effective treatment or vaccine available. Read More

    A comparative analysis of immunogenicity and safety of an enterovirus 71 vaccine between children aged 3-5 years and infants aged 6-35 months.
    Expert Rev Vaccines 2018 Mar 29;17(3):257-262. Epub 2018 Jan 29.
    a School of Public Health , Nanjing Medical University , Nanjing , PR China.
    Background: The Sinovac enterovirus 71 (EV71) vaccine has shown good safety, immunogenicity, and efficacy in infants aged 6-35 months, whom are considered as the priority of the target population. However, 3-5 years old children accounted for approximately 30% of HFMD cases and are also worth our attention.

    Methods: A randomized, double-blind, placebo-controlled, batch-to-batch consistency clinical trial enrolling 1400 participants aged 6-59 months was performed. Read More

    Epidemiological and serological surveillance of hand-foot-and-mouth disease in Shanghai, China, 2012-2016.
    Emerg Microbes Infect 2018 Jan 24;7(1). Epub 2018 Jan 24.
    Department of Microbiology and Immunology, Institutes of Medical Science, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Aside from enterovirus 71 (EV71) and coxsackie virus A16 (CV-A16), viruses that are known to cause hand-foot-and-mouth disease (HFMD), epidemiological profiles of other enteroviruses that induce HFMD are limited. We collected 9949 laboratory surveillance HFMD cases and 1230 serum samples from infants and children in Shanghai from 2012-2016. Since 2013, CV-A6 has displaced EV71 and CV-A16 to become the predominant serotype. Read More

    Identification and production of mouse scFv to specific epitope of enterovirus-71 virion protein-2 (VP2).
    Arch Virol 2018 Jan 22. Epub 2018 Jan 22.
    Faculty of Medicine Siriraj Hospital, Center of Research Excellence on Therapeutic Proteins and Antibody Engineering, Mahidol University, Bangkok, Thailand.
    Enterovirus-71 (EV71) and coxsackievirus-A16 (CA16) frequently cause hand-foot-mouth disease (HFMD) epidemics among infants and young children. CA16 infections are usually mild, while EV71 disease may be fatal due to neurologic complications. As such, the ability to rapidly and specifically recognize EV71 is needed to facilitate proper case management and epidemic control. Read More

    Poorly neutralizing polyclonal antibody in vitro against coxsackievirus A16 circulating strains can prevent a lethal challenge in vivo.
    Hum Vaccin Immunother 2018 Jan 16:1-8. Epub 2018 Jan 16.
    a Division Hepatitis Virus Vaccines, National Institute for Food and Drug Control , Beijing , PR China.
    Neutralizing antibodies (NTAbs) is a major criterion for evaluation the immunogenicity of many vaccines, for example, poliovirus and EV71 vaccine. Here, we firstly discovered that polyclonal antibodies induced by inactivated CVA16 vaccine and lived CVA16 virus have poor ability to neutralize circulating CVA16 strains in vitro. However, the passive transfer of poorly neutralizing polyclonal antibodies can protect suckling mice from lethally challenged with circulating strains in vivo. Read More

    Prohibitin plays a critical role in Enterovirus 71 neuropathogenesis.
    PLoS Pathog 2018 Jan 11;14(1):e1006778. Epub 2018 Jan 11.
    Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
    A close relative of poliovirus, enterovirus 71 (EV71) is regarded as an important neurotropic virus of serious public health concern. EV71 causes Hand, Foot and Mouth Disease and has been associated with neurological complications in young children. Our limited understanding of the mechanisms involved in its neuropathogenesis has hampered the development of effective therapeutic options. Read More

    Serological survey of neutralizing antibodies to eight major enteroviruses among healthy population.
    Emerg Microbes Infect 2018 Jan 10;7(1). Epub 2018 Jan 10.
    State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, 361102, China.
    Human enteroviruses (EVs) are the most common causative agents infecting human, causing many harmful diseases, such as hand, foot, and mouth disease (HFMD), herpangina (HA), myocarditis, encephalitis, and aseptic meningitis. EV-related diseases pose a serious worldwide threat to public health. To gain comprehensive insight into the seroepidemiology of major prevalent EVs in humans, we firstly performed a serological survey for neutralizing antibodies (nAbs) against Enterovirus A71 (EV-A71), Coxsackie virus A16 (CV-A16), Coxsackie virus A6 (CV-A6), Coxsackie virus A10 (CV-A10), Coxsackie virus B3 (CV-B3), Coxsackie virus B5 (CV-B5), Echovirus 25 (ECHO25), and Echovirus 30 (ECHO30) among the healthy population in Xiamen City in 2016, using micro-neutralization assay. Read More

    Genetic Characterization of Human Enteroviruses Associated with Hand, Foot and Mouth Diseases in Poland, 2013-2016.
    Pol J Microbiol 2017 Sep;66(3):405-409
    Department and Clinic of Pediatric Infectious Diseases, Wroclaw Medical University, Wroclaw, Poland.
    The objective of the present study was to describe the molecular characteristics of enteroviruses associated with hand, food, and mouth disease (HFMD) in Poland. Clinical material from HFMD cases, that occurred during 2013-2016 were examined. It has been showed that coxsackievirus A6 (CVA6), CVA10 and CVA16 were circulating in the country. Read More

    A novel rat CVB1-VP1 monoclonal antibody 3A6 detects a broad range of enteroviruses.
    Sci Rep 2018 Jan 8;8(1):33. Epub 2018 Jan 8.
    Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
    Enteroviruses (EVs) are common RNA viruses that cause diseases ranging from rash to paralytic poliomyelitis. For example, EV-A and EV-C viruses cause hand-foot and mouth disease and EV-B viruses cause encephalitis and myocarditis, which can result in severe morbidity and mortality. While new vaccines and treatments for EVs are under development, methods for studying and diagnosing EV infections are still limited and therefore new diagnostic tools are required. Read More

    Different responses of weather factors on hand, foot and mouth disease in three different climate areas of Gansu, China.
    BMC Infect Dis 2018 01 8;18(1):15. Epub 2018 Jan 8.
    School of Public Health and Social Work, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
    Background: To determine the linear and non-linear interacting relationships between weather factors and hand, foot and mouth disease (HFMD) in children in Gansu, China, and gain further traction as an early warning signal based on weather variability for HFMD transmission.

    Method: Weekly HFMD cases aged less than 15 and meteorological information from 2010 to 2014 in Jiuquan, Lanzhou and Tianshu, Gansu, China were collected. Generalized linear regression models (GLM) with Poisson link and classification and regression trees (CART) were employed to determine the combined and interactive relationship of weather factors and HFMD in both linear and non-linear ways. Read More

    Ambient temperature, humidity and hand, foot, and mouth disease: A systematic review and meta-analysis.
    Sci Total Environ 2018 Jan 4;625:828-836. Epub 2018 Jan 4.
    Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China. Electronic address:
    Background: The relationship between ambient temperature, humidity and hand, foot, and mouth disease (HFMD) has been highlighted in East and Southeast Asia, which showed multiple different results. Therefore, our goal is to conduct a meta-analysis to further clarify this relationship and to quantify the size of these effects as well as the susceptible populations.

    Methods: PubMed, Web of science, and Cochrane library were searched up to November 22, 2017 for articles analyzing the relationships between ambient temperature, humidity and incidence of HFMD. Read More

    Clinical characteristics of hand, foot and mouth disease in Daklak Province, Vietnam and associated factors of severe cases.
    Virusdisease 2017 Dec 20;28(4):430-433. Epub 2017 Sep 20.
    Pasteur Institute in Ho Chi Minh City, 167 Pasteur, District 3, Ho Chi Minh City, Vietnam.
    The Hand, Foot and Mouth Disease (HFMD) outbreaks occurred throughout Daklak province, Vietnam in 2011. This study reviewed all 744 medical records of HFMD patients admitted to Daklak Hospital in 2011 to describe the clinical characteristics of HFMD patients and determined factors associated with severe illness. Among 744 patients, 63 (8. Read More

    Pulmonary edema following central nervous system lesions induced by a non- mouse-adapted EV71 strain in neonatal BALB/c mice.
    Virol J 2017 Dec 28;14(1):243. Epub 2017 Dec 28.
    Department of Epidemiology, College of Public Health, Zhengzhou University, No.100 Kexue Avenue, Zhengzhou, Henan, 450001, China.
    Background: Enterovirus (EV) infection has been a serious health issue in Asia-Pacific region. It has been indicated that the occurrence of fatal hand foot and mouth disease (HFMD) cases following EV71 infection is mainly attributed to pulmonary edema. However, the development of pulmonary disorders after EV71 infection remains largely unknown. Read More

    Application of seasonal auto-regressive integrated moving average model in forecasting the incidence of hand-foot-mouth disease in Wuhan, China.
    J Huazhong Univ Sci Technolog Med Sci 2017 Dec 21;37(6):842-848. Epub 2017 Dec 21.
    Wuhan Centers for Disease Prevention and Control, Wuhan, 430015, China.
    Outbreaks of hand-foot-mouth disease (HFMD) have occurred many times and caused serious health burden in China since 2008. Application of modern information technology to prediction and early response can be helpful for efficient HFMD prevention and control. A seasonal auto-regressive integrated moving average (ARIMA) model for time series analysis was designed in this study. Read More

    'Outbreak Gold Standard' selection to provide optimized threshold for infectious diseases early-alert based on China Infectious Disease Automated-alert and Response System.
    J Huazhong Univ Sci Technolog Med Sci 2017 Dec 21;37(6):833-841. Epub 2017 Dec 21.
    Center for Disease Control and Prevention, Atlanta, 30329-4027, USA.
    The China Infectious Disease Automated-alert and Response System (CIDARS) was successfully implemented and became operational nationwide in 2008. The CIDARS plays an important role in and has been integrated into the routine outbreak monitoring efforts of the Center for Disease Control (CDC) at all levels in China. In the CIDARS, thresholds are determined using the "Mean+2SD‟ in the early stage which have limitations. Read More

    RSAD2 and AIM2 modulate CV-A16 and EV-A71 replication in neuronal cells in different ways that may be associated with their 5' non-translated regions.
    J Virol 2017 Dec 20. Epub 2017 Dec 20.
    Departments of Pathology and Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Coxsackievirus A16 (CV-A16) and Enterovirus A71 (EV-A71) are closely related enteroviruses that cause the same hand, foot and mouth disease but neurological complications occur only very rarely in CV-A16 compared to EV-A71 infections. To elucidate host responses that may be able to explain these differences, we performed transcriptomic analysis and qRT-PCR in CV-A16 infected neuroblastoma cells (SK-N-SH) which showed that the radical s-adenosyl methionine domain containing 2 (RSAD2) was the highest up-regulated gene in the anti-microbial pathway. Increased RSAD2 expression was correlated with reduced viral replication while RSAD2 knockdown cells were correlated with increased replication. Read More

    Epidemiology of hand, foot and mouth disease in China, 2008 to 2015 prior to the introduction of EV-A71 vaccine.
    Euro Surveill 2017 12;22(50)
    School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China.
    Introduction: Hand, foot and mouth disease (HFMD) is usually caused by several serotypes from human enterovirus A species, including enterovirus 71 (EV-A71) and coxsackievirus A16 (CV-A16). Two inactivated monovalent EV-A71 vaccines have been recently licensed in China and monovalent CV-A16 vaccine and bivalent EV-A71 and CV-A16 vaccine are under development.

    Methods: Using notifications from the national surveillance system, we describe the epidemiology and dynamics of HFMD in the country, before the introduction of EV-A71 vaccination, from 2008 through 2015. Read More

    Andrographolide sulfonate reduces mortality in Enterovirus 71 infected mice by modulating immunity.
    Int Immunopharmacol 2018 Feb 22;55:142-150. Epub 2017 Dec 22.
    College of Animal Science, Jilin University, Jilin 130062, China. Electronic address:
    Outbreaks of hand, foot and mouth disease (HFMD), which is caused by Enterovirus 71 (EV71), have erupted in recent years. Andrographolide sulfonate (Trade name: Xiyanping injection) has been recommended to treat severe HFMD in China because of its conventional antithermic and antitoxic activities, but its actual mechanism has not been revealed clearly until now. To explore its therapeutic efficacy and mechanism, a Xiyanping injection treatment mouse model was established. Read More

    Risk factors for death in children with critical and severe hand-foot-and-mouth disease in Chongqing, China: An observational study.
    Medicine (Baltimore) 2017 Dec;96(49):e8934
    Infection Department of the Children's Hospital, The Pediatrics Institution of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, The Children's Hospital of Chongqing Medical University, Chongqing, P.R. China.
    Hand-foot-and-mouth disease (HFMD) is a common childhood infection that may lead to serious complications and even death. Globally, epidemics of HFMD are increasing each year, especially in China. This study aimed to identify risk factors for death in children with critical and severe HFMD in Chongqing, China. Read More

    A Retrospective Study of 331 Deaths in Children with Severe Hand, Foot and Mouth Disease in Guangxi, China.
    Indian Pediatr 2017 Dec 14. Epub 2017 Dec 14.
    Departments of Pediatrics, The First Affiliated Hospitalof Guangxi Medical University, Nanning, Guangxi, and *The Third People's Hospital of Bengbu,Bengbu, Anhui; China. Correspondence to: Dr Dan Wei, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
    Objective: To analyze the clinical features of children with hand foot and mouth disease (HFMD) who died.

    Methods: 331 deaths due to HFMD were included in this retrospective study; 15 autopsies were performed.

    Results: Most cases were seen in children aged below 3 years, and with enterovirus 71 infection (91%). Read More

    Immunopathogenesis and Virus-Host Interactions of Enterovirus 71 in Patients with Hand, Foot and Mouth Disease.
    Front Microbiol 2017 28;8:2249. Epub 2017 Nov 28.
    Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.
    Enterovirus 71 (EV71) is a global infectious disease that affects millions of people. The virus is the main etiological agent for hand, foot, and mouth disease with outbreaks and epidemics being reported globally. Infection can cause severe neurological, cardiac, and respiratory problems in children under the age of 5. Read More

    Association of gene polymorphisms of pattern-recognition receptor signaling pathway with the risk and severity of hand, foot, and mouth disease caused by enterovirus 71 in Chinese Han population.
    J Med Virol 2018 Apr 5;90(4):692-698. Epub 2018 Jan 5.
    Department of Infectious Diseases, Second Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, China.
    Hand, foot, and mouth disease (HFMD) caused by enterovirus 71 (EV71) presents with a wide variety of clinical manifestations. Host immune response is a factor that influences disease susceptibility and severity. We investigated the potential association of gene polymorphisms in the pattern recognition receptor (PRR) pathway with the risk and severity of EV71 infection. Read More

    A flavonoid compound library screen revealed potent antiviral activity of plant-derived flavonoids on human enterovirus A71 replication.
    Antiviral Res 2018 02 9;150:60-68. Epub 2017 Dec 9.
    Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore; Collaborative and Translational Unit for HFMD, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore. Electronic address:
    Hand Foot Mouth Disease (HFMD), resulting from human enterovirus A71 (HEVA71) infection can cause severe neurological complications leading to fatality in young children. Currently, there is no approved antiviral for therapeutic treatment against HEVA71 infection. In this study, a 500-compound flavonoid library was screened to identify potential inhibitors of HEVA71 using high-throughput immunofluorescence-based phenotypic screening method. Read More

    Serum interleukin-6 levels as an indicator of aseptic meningitis among children with enterovirus 71-induced hand, foot and mouth disease.
    Postgrad Med 2017 Dec 14:1-6. Epub 2017 Dec 14.
    a Department of Pediatrics , College of Medicine, The Catholic University of Korea , Seoul , Republic of Korea.
    Objectives: The enterovirus EV71 is a major pathogen of hand, foot, and mouth disease (HFMD) in children. Aseptic meningitis is the most common neurologic complication of EV71-induced HFMD. Lumbar puncture is a crucial procedure in the diagnosis of aseptic meningitis. Read More

    Epidemiological and genetic characteristics of EV71 in hand, foot, and mouth disease in Guangxi, southern China, from 2010 to 2015.
    PLoS One 2017 7;12(12):e0188640. Epub 2017 Dec 7.
    Institute of Acute Infectious Diseases Control and Prevention, Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control, Nanning, Guangxi, China.
    Hand, foot, and mouth disease (HFMD) is a significant public health challenge in China. Human enterovirus 71 (EV71) is regarded as the predominant causative pathogen of HFMD. Since 2015, two inactivated EV71 vaccines have been approved in mainland China, and because their use could change the HFMD pathogen spectrum, this should now be monitored. Read More

    Estimating the incubation period of hand, foot and mouth disease for children in different age groups.
    Sci Rep 2017 Nov 28;7(1):16464. Epub 2017 Nov 28.
    WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
    Hand, foot and mouth disease (HFMD) is a childhood disease causing large outbreaks frequently in Asia and occasionally in Europe and the US. The incubation period of HFMD was typically described as about 3-7 days but empirical evidence is lacking. In this study, we estimated the incubation period of HFMD from school outbreaks in Hong Kong, utilizing information on symptom onset and sick absence dates of students diagnosed with HFMD. Read More

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