2,185 results match your criteria Hand-Foot-and-Mouth Disease


Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Periodontol 2018 Jun;89 Suppl 1:S74-S84

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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Hand-foot-mouth disease and use of steroids, intravenous immunoglobulin, and traditional Chinese herbs in a tertiary hospital in Shantou, China.

BMC Complement Altern Med 2018 Jun 20;18(1):190. Epub 2018 Jun 20.

Shantou-Oxford Clinical Research Unit, Shantou University Medical College, Shantou, Guangdong, 515040, People's Republic of China.

Background: In contrast to the guidelines of World Health Organization (WHO) and United States-Centers for Disease Control and prevention (US-CDC), the Chinese national guidelines recommend the use of steroids, intravenous immunoglobulin (IVIG), or traditional Chinese herbs (TCHs) in hand-foot-mouth disease (HFMD) management. Their use and therapeutic efficacies are, however, unclear. We aimed to describe their use in and the clinical outcomes of hospitalized HFMD cases. Read More

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Enterovirus A71 Infection, Thailand, 2017.

Emerg Infect Dis 2018 Jul;24(7):1386-1387

An outbreak of hand, foot and mouth disease among children in Thailand peaked in August 2017. Enterovirus A71 subgenogroup B5 caused most (33.8%, 163/482) cases. Read More

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Correction to: Correlation analysis on serum inflammatory cytokine level and neurogenic pulmonary edema for children with severe hand-foot-mouth disease.

Eur J Med Res 2018 Jun 15;23(1):33. Epub 2018 Jun 15.

Department of Infections Disease, Zaozhuang Municipal Hospital, Leading Road No. 41, Shizhong District, Zaozhuang, 277100, Shandong, China.

The original publication of this article [1] contained two erroneous paragraphs related to the time and place for the admission of the pediatric patients with clinically diagnosed severe HFMD. The updated information has been indicated in bold. Read More

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June 2018
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Time series model for forecasting the number of new admission inpatients.

BMC Med Inform Decis Mak 2018 Jun 15;18(1):39. Epub 2018 Jun 15.

Department of Information, Research Institute of Field Surgery, Daping Hospital of Army Medical University, 10 Changjiang Access Road, Chongqing, 400042, China.

Background: Hospital crowding is a rising problem, effective predicting and detecting managment can helpful to reduce crowding. Our team has successfully proposed a hybrid model combining both the autoregressive integrated moving average (ARIMA) and the nonlinear autoregressive neural network (NARNN) models in the schistosomiasis and hand, foot, and mouth disease forecasting study. In this paper, our aim is to explore the application of the hybrid ARIMA-NARNN model to track the trends of the new admission inpatients, which provides a methodological basis for reducing crowding. Read More

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Changes in the EV-A71 Genome through Recombination and Spontaneous Mutations: Impact on Virulence.

Viruses 2018 06 12;10(6). Epub 2018 Jun 12.

Centre for Virus and Vaccine Research, School of Science and Technology, Sunway University, Kuala Lumpur, Selangor 47500, Malaysia.

Enterovirus 71 (EV-A71) is a major etiological agent of hand, foot and mouth disease (HFMD) that mainly affects young children less than five years old. The onset of severe HFMD is due to neurological complications bringing about acute flaccid paralysis and pulmonary oedema. In this review, we address how genetic events such as recombination and spontaneous mutations could change the genomic organization of EV-A71, leading to an impact on viral virulence. Read More

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Genome-wide linear B-cell epitopes of enterovirus 71 in a hand, foot and mouth disease (HFMD) population.

J Clin Virol 2018 Jun 3;105:41-48. Epub 2018 Jun 3.

Department of pathogen diagnosis and biosafety, Shanghai public health clinical center, Fudan University, Shanghai, 201508, PR China. Electronic address:

Background: Enteroviruses cause hand, foot and mouth disease (HFMD). The host B-cells recognize the viral proteins and provoke humoral responses. Deciphering the B-cell responses to the viral epitopes helps diagnosis and vaccine development. Read More

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June 2018
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Pyroptosis induced by enterovirus A71 infection in cultured human neuroblastoma cells.

Virology 2018 Jun 7;521:69-76. Epub 2018 Jun 7.

Institute of Pathogenic Microbiology, Key Laboratories of Enteric Pathogenic Microbiology (Ministry of Health), Jiangsu Provincial Center for Disease Control and Prevention, 172 JiangSu Road, Nanjing 210009, China; Key Laboratory of Infectious Diseases, Nanjing Medical University, Nanjing 211166, China. Electronic address:

Enterovirus A71 (EV-A71) infection can cause hand, foot and mouth disease (HFMD), and even fatal meningoencephalitis. Unfortunately, there is currently no effective treatment for EV-A71 infection due to the lack of understanding of the mechanism of neurological diseases. In this study, we employed SH-SY5Y human neuroblastoma cells to explore the roles of caspase-1 in neuropathogenesis. Read More

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Hand, Foot, and Word of Mouth: Combined Transradial and Transpedal Access for Femoral Artery Interventions.

JACC Cardiovasc Interv 2018 Jun;11(11):1072-1073

Veterans Affairs Eastern Colorado Health Care System, Denver, Colorado; University of Colorado School of Medicine, Aurora, Colorado.

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Atypical Presentation of Hand, Foot, and Mouth Disease in an Adult.

Clin Pract Cases Emerg Med 2018 May 17;2(2):179-180. Epub 2018 Apr 17.

Martin Army Community Hospital, Department of Emergency Medicine, Fort Benning, Georgia.

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VP1 amino acid residue 145 of enterovirus 71 is a key residue for its receptor attachment and resistance to neutralizing antibody during cynomolgus monkey infection.

J Virol 2018 May 30. Epub 2018 May 30.

Neurovirology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

Enterovirus 71 (EV71) is a causative agent of hand, foot, and mouth disease and sometimes causes severe or fatal neurological complications. The amino acid at VP1-145 determines virological characteristics of EV71. Viruses with glutamic acid (E) at VP1-145 (VP1-145E) are virulent in neonatal mice and transgenic mice expressing human scavenger receptor B2, whereas those with glutamine (Q) or glycine (G) are not. Read More

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Hand, Foot and Mouth Disease in the Andaman Islands, India.

Indian Pediatr 2018 May;55(5):408-410

Regional Medical Research Centre (ICMR), Port Blair, A and N Islands, India. Correspondence to: Dr Vijayachari Paluru, Director and Scientist-G, Regional Medical Research Centre (ICMR), Post bag No. 13, Dollygunj, Port Blair - 744 101, Andaman and Nicobar Islands, India.

Objective: To investigate an outbreak of Hand, foot and mouth disease (HFMD) in Andaman Islands during 2013.

Methods: Epidemiological, clinical data and samples were collected from HFMD patients who attended selected hospitals. Data were analyzed and samples were processed for detection of Enterovirus and further confirmed by sequencing. Read More

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Reinfection hazard of hand-foot-mouth disease in Wuhan, China, using Cox-proportional hazard model.

Epidemiol Infect 2018 May 30:1-6. Epub 2018 May 30.

Wuhan Center for Disease Prevention and Control,Wuhan 430015,China.

Hand-foot-mouth disease (HFMD) is an acute infectious disease caused by serotypes of the enterovirus (EV) family. HFMD reinfection occurs commonly in lack of cross-protection between different EV serotypes. In this study, we investigated the hazards of HFMD reinfection using Cox-proportional hazard model. Read More

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May 2018
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Involvement of the renin-angiotensin system in the progression of severe hand-foot-and-mouth disease.

PLoS One 2018 23;13(5):e0197861. Epub 2018 May 23.

Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan Province, China.

Background: Hand-foot-and-mouth disease (HFMD) is generally considered as a mild exanthematous disease to infants and young children worldwide. HFMD cases are usually mild and self-limiting but for few cases leads to complicated severe clinical outcomes, and even death. Previous studies have indicated that serum Ang II levels in patients with H7N9 infection were related to the severity of infection. Read More

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May 2018
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Outcomes following severe hand foot and mouth disease: A systematic review and meta-analysis.

Eur J Paediatr Neurol 2018 Apr 20. Epub 2018 Apr 20.

Oxford University Clinical Research Unit, Ha Noi, Viet Nam; Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, Oxford University, Oxford, UK.

Background: Hand, foot and mouth disease (HFMD) caused by enterovirus A71 (EV-A71) is associated with acute neurological disease in children. This study aimed to estimate the burden of long-term sequelae and death following severe HFMD.

Methods: This systematic review and meta-analysis pooled all reports from English and Chinese databases including MEDLINE and Wangfang on outbreaks of clinically diagnosed HFMD and/or laboratory-confirmed EV-A71 with at least 7 days' follow-up published between 1st January 1966 and 19th October 2015. Read More

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April 2018
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A virus-like particle-based tetravalent vaccine for hand, foot, and mouth disease elicits broad and balanced protective immunity.

Emerg Microbes Infect 2018 May 18;7(1):94. Epub 2018 May 18.

Vaccine Research Center, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.

Hand, foot, and mouth disease (HFMD) is an infectious disease that mainly affects infants and children, causing considerable morbidity and mortality worldwide. HFMD is commonly caused by enterovirus 71 (EV71) and coxsackieviruses A16 (CVA16), A6 (CVA6), and A10 (CVA10). Formalin-inactivated EV71 vaccines are currently available in China; however, these vaccines fail to confer cross-protection against infections by other HFMD-causing enteroviruses, highlighting the necessity of developing a multivalent HFMD vaccine. Read More

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Willingness and influential factors of parents to vaccinate their children with novel inactivated enterovirus 71 vaccines in Guangzhou, China.

Vaccine 2018 06;36(26):3772-3778

Guangzhou Centre for Diesease Control and Prevention, Guanghzou, China.

Hand, foot and mouth disease (HFMD) primarily affects children younger than 5 years of age. Recently, HFMD has ranked as the top notifiable infectious disease in China. In December 2015, China approved two novel inactivated enterovirus 71 vaccines (EV71 vaccines) for HFMD. Read More

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Development and evaluation of a rapid recombinase polymerase amplification assay for the detection of human enterovirus 71.

Arch Virol 2018 May 16. Epub 2018 May 16.

Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, 510515, China.

Enterovirus 71 (EV71) is one of the most common pathogens of hand, foot, and mouth disease (HFMD). A rapid reverse transcription recombinase polymerase amplification (RT-RPA) assay was established to detect EV71 subgenotype C4 (EV71-C4). The 95% detection limit of the RT-RPA was 3. Read More

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May 2018
5 Reads

Hand, foot, and mouth disease photolocalized to sunburn.

Pediatr Dermatol 2018 May 16. Epub 2018 May 16.

Phoenix Children's Hospital, Phoenix, AZ, USA.

Hand, foot, and mouth disease is a common exanthem linked to infection with several non-polio enteroviruses. This case of an 11-year-old boy with an enteroviral infection limited to areas of sunburn is an atypical presentation of hand, foot, and mouth disease. Recognition of this unusual distribution will allow pediatricians and pediatric dermatologists to appropriately manage and counsel patients and parents. Read More

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Mast cells contribute to Enterovirus 71 infection-induced pulmonary edema in neonatal mice.

Lab Invest 2018 May 15. Epub 2018 May 15.

Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.

Enterovirus (EV) 71 infection has been widely acknowledged as the leading cause of severe hand, foot and mouth disease (HFMD), which may rapidly lead to fatal pulmonary edema. In this study, we established a mouse model for EV71 infection exhibiting high incidence of severe symptoms with pulmonary edema. Mast cells (MCs) accumulation, activation and allergic inflammation were found in the brains, lungs and skeletal muscle of mice after EV71 infection, especially in the lungs of mice. Read More

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May 2018
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Evaluation of MinION nanopore sequencing for rapid enterovirus genotyping.

Virus Res 2018 07 12;252:8-12. Epub 2018 May 12.

Genecology Research Centre, School of Science and Engineering, University of the Sunshine Coast, 90 Sippy Downs Dr, Sippy Downs, Queensland, Australia; Division of Experimental Therapeutics, Department of Medicine, Columbia University, NY, USA. Electronic address:

Enteroviruses (EV) are associated with a range of serious infections, including aseptic meningitis, hand foot and mouth disease, myocarditis, acute flaccid paralysis and encephalitis. Improved methods for assessing EV genotypic diversity could assist molecular epidemiology studies, clinical diagnosis and environmental surveillance. We report new methods for EV genome amplification, and subsequent genotyping using the miniaturised MinION sequencing device. Read More

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July 2018
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Rapid detection of hand, foot and mouth disease enterovirus genotypes by multiplex PCR.

J Virol Methods 2018 08 26;258:7-12. Epub 2018 May 26.

Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Taishan Medical College, Taian, 271000, Shandong, China. Electronic address:

Hand, foot and mouth disease (HFMD) is a pediatric disease associated with infection by enterovirus (EV) genotypes. The major HFMD EV pathogens are enterovirus A71 (EVA71) and coxsackievirus A16 (CVA16); however, recently, coxsackievirus A6 (CVA6) and coxsackievirus A10 (CVA10) have also emerged. EV genotypes cannot be distinguished on clinical grounds and a new methodology for the rapid detection of the four major HFMD EV genotypes is urgently required. Read More

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August 2018
2 Reads

Caspase-3 Inhibition Attenuates the Cytopathic Effects of EV71 Infection.

Front Microbiol 2018 26;9:817. Epub 2018 Apr 26.

Institute of Virology and AIDS Research, The First Hospital of Jilin University, Jilin University, Changchun, China.

Previous studies demonstrate that human enterovirus 71 (EV71), a primary causative agent for hand, foot, and mouth disease, activates caspase-3 through the non-structural viral 3C protein to induce host cell apoptosis; however, until now it was unclear how 3C activates caspase-3 and how caspase-3 activation affects viral production. Our results demonstrate that 3C binds caspase-8 and caspase-9 but does not directly bind caspase-3 to activate them, and that the proteolytic activity of 3C is required by the activation of caspase-8, caspase-9, and caspase-3. Inhibition of caspase-3 activity attenuates apoptosis in 3C-transfected cells. Read More

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Circulating Salivary miRNA hsa-miR-221 as Clinically Validated Diagnostic Marker for Hand, Foot, and Mouth Disease in Pediatric Patients.

EBioMedicine 2018 May 10;31:299-306. Epub 2018 May 10.

Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System, 5 Science Drive 2, National University of Singapore, 117597, Singapore; Collaborative and Translational Unit for HFMD, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore. Electronic address:

Enhancements in the diagnostic capabilities using host biomarkers are currently much needed where sensitivity and specificity issues plague the diagnosis of Hand, Foot and Mouth Disease (HFMD) in pediatrics clinical samples. We investigated miRNome profiles of HFMD saliva samples against healthy children and developed miRNA-based diagnosis models. Our 6-miRNA scoring model predicted HFMD with an overall accuracy of 85. Read More

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May 2018
9 Reads

Enterovirus and Parechovirus Surveillance - United States, 2014-2016.

MMWR Morb Mortal Wkly Rep 2018 May 11;67(18):515-518. Epub 2018 May 11.

Division of Viral Diseases, National Center for Immunization and Respiratory Disease, CDC.

Infections caused by enteroviruses (EV) and parechoviruses (PeV), members of the Picornaviridae family, are associated with various clinical manifestations, including hand, foot, and mouth disease; respiratory illness; myocarditis; meningitis; and sepsis; and can result in death. The genus Enterovirus includes four species of enterovirus (A-D) known to infect humans, and the genus Parechovirus includes one species (A) that infects humans. These species are further divided into types, some of which are associated with specific clinical manifestations. Read More

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May 2018
1 Read

The immunogenicity and protection effect of an inactivated coxsackievirus A6, A10, and A16 vaccine against hand, foot, and mouth disease.

Vaccine 2018 06 5;36(24):3445-3452. Epub 2018 May 5.

Division of Vaccine Research, National Institute of Health, Centers for Disease Control and Prevention, Osong, CheongJu, Chungcheongbuk-do, South Korea. Electronic address:

Coxsackievirus belongs to the Enterovirus genus of the Picornaviridae family and is one of the major pathogens associated with human hand, foot, and mouth disease (HFMD). Historically, outbreaks of HFMD have mainly been caused by enterovirus 71 and coxsackievirus A16. Recently, coxsackieviruses A6 and A10 have been associated with increased occurrences of sporadic HFMD cases and outbreak events globally. Read More

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June 2018
4 Reads

Floods Increase the Risks of Hand-Foot-Mouth Disease in Qingdao, China, 2009-2013: A Quantitative Analysis.

Disaster Med Public Health Prep 2018 May 8:1-7. Epub 2018 May 8.

2Women and Children's Hospital,Qingdao University,Qingdao City,Shandong Province,P. R. China.

Background: We aimed to quantify the impact of few times floods on hand-foot-mouth disease (HFMD) in Qingdao during 2009-2013.

Methods: The Spearman correlation test was applied to examine the lagged effects of floods on monthly morbidity of HFMD during study period in Qingdao. We further quantified the effects of 5 flood events on the morbidity of HFMD using the time-series Poisson regression controlling for climatic factors, seasonality, and lagged effects among different populations. Read More

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Atypical Presentation of Incomplete Kawasaki Disease: A Peripheral Facial Nerve Palsy.

J Emerg Med 2018 Jul 3;55(1):118-120. Epub 2018 May 3.

Pediatric Department of Hospital Universitario Puerta del Mar, Cadiz, Spain.

Background: Kawasaki disease (KD) is a multisystem vasculitic disease. Coronary artery aneurysms (CAAs) are the most important and life-threatening complication of KD. Various neurologic complications have been described to occur in 1-30% of patients with KD, but peripheral facial nerve palsy (FNP) is rare (0. Read More

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Critical anemia · light-headedness · bilateral leg swelling · Dx?

J Fam Pract 2018 May;67(5):302-304

Mercy Health Saint Mary's, Grand Rapids, Michigan, USA.

40-year-old man was referred to the emergency department (ED) with critical anemia after routine blood work at an outside clinic showed a hemoglobin level of 3.5 g/dL. On presentation, he reported symptoms of fatigue, shortness of breath, bilateral leg swelling, dizziness (characterized as light-headedness), and frequent heartburn. Read More

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May 2018
1 Read

Correlation analysis on serum inflammatory cytokine level and neurogenic pulmonary edema for children with severe hand-foot-mouth disease.

Eur J Med Res 2018 May 3;23(1):21. Epub 2018 May 3.

Department of Infections Disease, Zaozhuang Municipal Hospital, Leading Road No. 41, Shizhong District, Zaozhuang, 277100, Shandong, China.

Objective: This study aims to discuss the correlation between serum inflammatory cytokines and neurogenic pulmonary edema (NPE) in children with severe hand-foot-mouth disease (HFMD).

Methods: A total of 89 patients with severe HFMD were enrolled into this study. These patients were divided into two groups, according to the presence of NPE: central nervous system disease (CNSD) group and NPE group. Read More

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May 2018
1 Read

Mutations in VP1 and 5'-UTR affect enterovirus 71 virulence.

Sci Rep 2018 Apr 27;8(1):6688. Epub 2018 Apr 27.

National Institute of Infectious Disease and Vaccinology, National Health Research Institutes, Zhunan, 350, Taiwan.

Enterovirus 71 (EV71) is a major cause of hand, foot and mouth disease (HFMD). The current EV71 propagating in Vero (EV-V) or sub-passaged in RD (EV-R) cells was used as a pathogen. Interestingly, EV-R exhibited differential virulence; challenging human scavenger receptor class B2-expressing (hSCARB2-Tg) mice with EV71 revealed that EV-V was more virulent than EV-R: 100% of mice that received lethal amounts of EV-V died, while all the mice that received EV-R survived. Read More

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April 2018
5 Reads

Crosstalk between Toll-like receptor 3 and Notch signaling contributes to CD14 monocytes activity in enterovirus 71 infected hand, foot, and mouth disease.

Int Immunopharmacol 2018 Jul 24;60:26-33. Epub 2018 Apr 24.

Department of Pediatrics, First Affiliated Hospital of Xinxiang Medical University, Weihui, Xinxiang, Henan Province, PR China. Electronic address:

Interaction between Toll-like receptor (TLR) and Notch signaling contributes to inflammatory response in nephropathy and fungicidal infection, however, the role of this crosstalk remains not fully elucidated in enterovirus 71 (EV71)-induced hand, foot, and mouth disease (HFMD). The aim of this study was to investigate the crosstalk between TLR and Notch in inflammatory regulation in EV71 infection. Thirty-seven EV-71-indcued HFMD (16 mild and 21 severe cases) and eleven normal control (NC) were enrolled. Read More

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July 2018
2 Reads

Potency of a Scalable Nanoparticulate Subunit Vaccine.

Nano Lett 2018 May 30;18(5):3007-3016. Epub 2018 Apr 30.

Center for Functional Biomaterials, School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education , Sun Yat-sen University , Guangzhou 510275 , China.

Nanoparticulate vaccines can potentiate immune responses by site-specific drainage to lymph nodes (LNs). This approach may benefit from a nanoparticle engineering method with fine control over size and codelivery of antigen and adjuvant. Here, we applied the flash nanocomplexation (FNC) method to prepare nanovaccines via polyelectrolyte complexation of chitosan and heparin to coencapsulate the VP1 protein antigen from enterovirus 71, which causes hand-foot-mouth disease (HFMD), with tumor necrosis factor α (TNF) or CpG as adjuvants. Read More

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May 2018
4 Reads

Spectrum of Enterovirus Serotypes Causing Uncomplicated Hand, Foot, and Mouth Disease and Enteroviral diagnostic yield of different clinical samples.

Clin Infect Dis 2018 Apr 24. Epub 2018 Apr 24.

Division of Infectious Disease, Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Centre for Disease Control and Prevention, Beijing, China.

Background: Hand, foot, and mouth disease (HFMD) represents a substantial disease burden in the Western Pacific region. We investigated the spectrum of causative enteroviruses of HFMD, and evaluated different clinical samples' diagnostic yield for enteroviruses.

Methods: We enrolled pediatric patients hospitalized for HFMD among six hospitals in Anhua County, Hunan Province, China between October 2013 and September 2016. Read More

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April 2018
2 Reads

microRNA-4516 Contributes to Different Functions of Epithelial Permeability Barrier by Targeting Poliovirus Receptor Related Protein 1 in Enterovirus 71 and Coxsackievirus A16 Infections.

Front Cell Infect Microbiol 2018 9;8:110. Epub 2018 Apr 9.

Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China.

Enterovirus 71 (EV-A71) and coxsackievirus A16 (CV-A16) remain the predominant etiological agents of hand, foot, and mouth disease (HFMD). The clinical manifestations caused by the two viruses are obviously different. CV-A16 usually triggers a repeated infection, and airway epithelial integrity is often the potential causative factor of respiratory repeated infections. Read More

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April 2018
2 Reads

Detection of hand-foot-mouth disease and its spatial-temporal Epidemiological characteristics with GIS platform.

J Biol Regul Homeost Agents 2018 Mar-Apr;32(2):371-377

Information and Management School, Guangxi Medical University, Nanning, Guangxi, China.

The aim of this study is to investigate the main category of hand-foot-mouth (HFM) virus and analyze the distribution characteristics and susceptible population of HFM disease in China. Infants who have had HFM disease for less than 7 days were selected from the First Affiliated Hospital of Guangxi Medical University, Guangxi, China. Various specimens were collected from the infants, and EV71 and CA16 nucleic acid detections were performed using fluorescence quantitative assay. Read More

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KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses.

Cell Host Microbe 2018 05 19;23(5):636-643.e5. Epub 2018 Apr 19.

Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria; CGC.nl, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. Electronic address:

Human type A Enteroviruses (EV-As) cause diseases ranging from hand-foot-and-mouth disease to poliomyelitis-like disease. Although cellular receptors are identified for some EV-As, they remain elusive for the majority of EV-As. We identify the cell surface molecule KREMEN1 as an entry receptor for coxsackievirus A10 (CV-A10). Read More

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Modeling the Present and Future Incidence of Pediatric Hand, Foot, and Mouth Disease Associated with Ambient Temperature in Mainland China.

Environ Health Perspect 2018 04 20;126(4):047010. Epub 2018 Apr 20.

Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

Background: There is limited evidence about the association between ambient temperature and the incidence of pediatric hand, foot, and mouth disease (HFMD) nationwide in China.

Objectives: We examined the childhood temperature-HFMD associations across mainland China, and we projected the change in HFMD cases due to projected temperature change by the 2090s.

Methods: Data on daily HFMD (children 0-14 y old) counts and weather were collected from 362 sites during 2009-2014. Read More

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April 2018
2 Reads

Hand, Foot and Mouth Disease and Echovirus 3: A Comment to Høgsberg and Bygum.

Acta Derm Venereol 2018 Apr 12. Epub 2018 Apr 12.

Infectious Diseases and Dermatology Unit, Centre Hospitalier de Fréjus-Saint-Raphaël, 240 avenue Saint Lambert, FR-83600 Fréjus, France.

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April 2018
1 Read

Enterovirus serotypes in patients with central nervous system and respiratory infections in Viet Nam 1997-2010.

Virol J 2018 04 12;15(1):69. Epub 2018 Apr 12.

Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam.

Background: Enteroviruses are the most common causative agents of human illness. Enteroviruses have been associated with regional and global epidemics, recently, including with severe disease (Enterovirus A71 and D68), and are of interest as emerging viruses. Here, we typed Enterovirus A-D (EV) from central nervous system (CNS) and respiratory infections in Viet Nam. Read More

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April 2018
3 Reads

The dynamics of the hand, foot and mouth disease epidemic from 2008 to 2016 in Zhenjiang city, China.

Future Microbiol 2018 Apr 10. Epub 2018 Apr 10.

Pathogen Discovery & Big Data Center, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai 200031, PR China.

Aim: To investigate the hand, foot and mouth disease (HFMD) epidemic in Zhenjiang, China from 2008 to 2016.

Materials & Methods: A total of 37,202 HFMD cases were investigated and 3707 nasopharyngeal swabs were detected for enterovirus RNA using RT-quantitative PCR.

Results: We first reported a mixed pattern of HFMD seasonal epidemic with a combination of single-peak and two-peak patterns in alternate years, and the occurrence of sporadic and epidemic outbreaks of HFMD in kindergartens in Zhenjiang. Read More

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April 2018
2 Reads

The life cycle of non-polio enteroviruses and how to target it.

Nat Rev Microbiol 2018 Jun;16(6):368-381

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.

The genus Enterovirus (EV) of the family Picornaviridae includes poliovirus, coxsackieviruses, echoviruses, numbered enteroviruses and rhinoviruses. These diverse viruses cause a variety of diseases, including non-specific febrile illness, hand-foot-and-mouth disease, neonatal sepsis-like disease, encephalitis, paralysis and respiratory diseases. In recent years, several non-polio enteroviruses (NPEVs) have emerged as serious public health concerns. Read More

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June 2018
12 Reads

Inactivated enterovirus 71 with poly-γ-glutamic acid/Chitosan nano particles (PC NPs) induces high cellular and humoral immune responses in BALB/c mice.

Arch Virol 2018 Apr 4. Epub 2018 Apr 4.

College of Veterinary Medicine, Chungnam National University, 220 Gung-Dong, Yuseong-Gu, Daejeon, 34134, Republic of Korea.

Enterovirus 71 (EV71) is the major causative agent of hand-foot-and-mouth disease (HFMD) and many neurological manifestations. Recently, this virus has become a serious concern because of consecutive epidemics in the Asia-Pacific region. However, no effective vaccine for EV71 has been discovered except two EV71 vaccines which are being used in local communities of China. Read More

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April 2018
4 Reads

Hand, Foot, and Mouth Disease in an Adult.

N Engl J Med 2018 Apr;378(14):e20

Nagoya University Graduate School of Medicine, Nagoya, Japan

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April 2018
1 Read

Spatio-temporal analysis of the relationship between meteorological factors and hand-foot-mouth disease in Beijing, China.

BMC Infect Dis 2018 Apr 3;18(1):158. Epub 2018 Apr 3.

Research School of Population Health, College of Medicine, Biology and Environment, The Australian National University, Canberra, ACT, Australia.

Background: Hand-foot-mouth disease (HFMD) is a common infectious disease in China and occurs mostly in infants and children. Beijing is a densely populated megacity, in which HFMD has been increasing in the last decade. The aim of this study was to quantify spatio-temporal characteristics of HFMD and the relationship between meteorological factors and HFMD incidence in Beijing, China. Read More

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April 2018
6 Reads

[Study on early warning threshold values for 7 common communicable diseases in Gansu province, 2016].

Zhonghua Liu Xing Bing Xue Za Zhi 2018 Mar;39(3):352-356

Institute for Communicable Disease Control and Prevention, Gansu Provincial Center for Disease Control and Prevention, Lanzhou 730000, China.

To optimize the warning threshold values of common communicable diseases in Gansu province, and improve the early warning effect. An early warning model was set up for influenza, scarlet fever, other infectious diarrheal diseases, dysentery, typhoid and paratyphoid, viral hepatitis type E and hand foot and mouth disease (HFMD) respectively in Gansu by using the moving percentile method and cumulative sum method. By calculating the sensitivity, specificity, predictive value of positive test, predictive value of negative test, Youden' index and receiver-operating characteristic curve, the optimum early warning threshold values for communicable diseases in Gansu were selected. Read More

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