2,422 results match your criteria Hand-Foot-and-Mouth Disease


Enterovirus A71 Containing Codon-Deoptimized VP1 and High-Fidelity Polymerase as Next Generation Vaccine Candidate.

J Virol 2019 Apr 17. Epub 2019 Apr 17.

Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan

Enterovirus A71 (EV-A71) is the major pathogen which causes hand-foot-and-mouth disease (HFMD) which occasionally results in severe neurological complications. In this study, we developed four EV-A71 (rgEV-A71) strains by reverse genetics procedures as possible vaccine candidates. The four rgEV-A71 viruses contained various codon deoptimized VP1 capsid protein (VP1-CD) showed similar replication rate and antigenicity to wild-type virus, while a fifth virus, rg4643C4VP-CD, was unable to form plaques, but was still able to examined by TCID50 titers which were similar to the others, thus indicating the effect of CD on plaque formation. Read More

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http://dx.doi.org/10.1128/JVI.02308-18DOI Listing
April 2019
1 Read

Hand-foot-and-mouth-disease-induced Koebner phenomenon in psoriasis.

J Dtsch Dermatol Ges 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Cathay General Hospital, Taipei, Taiwan.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ddg.13824
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http://dx.doi.org/10.1111/ddg.13824DOI Listing
April 2019
1 Read

Spatiotemporal Distribution of Hand, Foot, and Mouth Disease in Guangdong Province, China and Potential Predictors, 2009⁻2012.

Int J Environ Res Public Health 2019 Apr 3;16(7). Epub 2019 Apr 3.

Department of Medical Statistic and Epidemiology, School of Public Health, Sun Yat-sen University, 74 Zhong Shan 2nd Road, Guangzhou 510080, China.

: Hand, foot, and mouth disease (HFMD) is a common infectious disease among children. Guangdong Province is one of the most severely affected provinces in south China. This study aims to identify the spatiotemporal distribution characteristics and potential predictors of HFMD in Guangdong Province and provide a theoretical basis for the disease control and prevention. Read More

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http://dx.doi.org/10.3390/ijerph16071191DOI Listing

Enterovirus 71 Suppresses miR-17-92 Cluster Through Up-Regulating Methylation of the miRNA Promoter.

Front Microbiol 2019 28;10:625. Epub 2019 Mar 28.

School of Life Sciences, Ningxia University, Yinchuan, China.

Enterovirus 71 (EV71), the etiological agent of hand-foot-and-mouth disease, has become an increasing public health challenge worldwide. Accumulating evidence suggests that mammalian microRNAs (miRNAs), a class of non-coding RNAs of 18 to 24 nucleotides (nt) with important regulatory roles in cellular processes, participate in host antiviral defense and studies have suggested roles of miRNAs in EV71 replication and pathogenesis. In the current study, we reported that the expression of hsa-miR-17∼92 cluster was significantly downregulated during EV71 infection. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00625
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http://dx.doi.org/10.3389/fmicb.2019.00625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447709PMC
March 2019
2 Reads

The rash with maculopapules and fever in children.

Clin Dermatol 2019 Mar - Apr;37(2):119-128. Epub 2018 Dec 5.

Dermatology Department, University of CT Health Center, Farmington, Connecticut, USA. Electronic address:

Several medical conditions can cause children to present with fever and a maculopapular rash Although some presentations are benign, others may be medical emergencies, which warrant a prompt diagnosis. We review some of the more common causes of fever and maculopapular dermatitirs, rash including infectious processes (roseola; rubeola; rubella; parvovirus B19; hand, foot, and mouth disease; scarlet fever; meningococcemia; Epstein-Barr virus infection), hypersensitivity reactions (exanthematous drug reactions), and vasculitis syndromes (Kawasaki disease). We have included a diagnostic algorithm to facilitate rapid identification of the etiology of the rash and fever. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0738081X183025
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http://dx.doi.org/10.1016/j.clindermatol.2018.12.005DOI Listing
December 2018
3 Reads

Compendium of hand, foot and mouth disease data in Malaysia from years 2010-2017.

Data Brief 2019 Jun 20;24:103868. Epub 2019 Mar 20.

Institute of Tropical Biodiversity and Sustainable Development, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia.

This data article is constructed using information from hand, foot and mouth disease outbreaks in every Malaysian state. Important information like total number of cases from every state and age group, humidity, air temperature and wind as well as types of viruses isolated from patients infected with hand, foot and mouth disease were gathered and sorted into four tables. The information sources include Malaysian Administrative Modernisation and Management Planning Unit (MAMPU), National Centre for Biotechnology Information (NCBI) and National Oceanic and Atmospheric Administration (NOAA). Read More

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http://dx.doi.org/10.1016/j.dib.2019.103868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441719PMC

Molecular characteristic analysis for the VP1 region of coxsackievirus A6 strains isolated in Jiujiang area, China, from 2012 to 2013.

Medicine (Baltimore) 2019 Apr;98(14):e15077

Department of Histology and Embryology, Bengbu Medical College, Bengbu, Anhui, P.R. China.

Background: Enterovirus 71 (EV-A71) and Coxsackievirus A16 (CV-A16) are the most common causative agents causing hand, foot, and mouth disease (HFMD). However, coxsackievirus A6 (CV-A6), previously largely ignored, became the predominant pathogen in China in 2012. The objective of this study is to investigate the genetic characteristics and molecular epidemiology of HFMD caused by CV-A6 to guide the diagnosis and treatment of the disease, as well as disease prevention. Read More

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http://dx.doi.org/10.1097/MD.0000000000015077DOI Listing
April 2019
2 Reads

Immunohistochemical Study of 2 Cases of Coxsackie A6-Induced Atypical Hand-Foot-and-Mouth Disease.

Am J Dermatopathol 2019 Mar 20. Epub 2019 Mar 20.

Department of Dermatology, Fundación de Investigación Biomédica del Hospital Universitario de La Princesa, Madrid, Spain.

An atypical clinical variant of hand-foot-and-mouth disease (HFMD) with more extensive lesions and affecting adults has emerged during the past years, usually associated to the Coxsackievirus serotype A6 (CV-A6). We present a 19-year-old woman with a 3-day evolution eruption of papulovesicular lesions, which first appeared around the mouth and frontal area and rapidly spread. In addition, we present a 61-year-old man with a 4-day evolution asymptomatic eruption of papulovesicular lesions in both the hands and feet after suffering a cold 1 week before. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001409DOI Listing
March 2019
4 Reads

Distinct expression and clinical value of aquaporin 4 in children with hand, foot and mouth disease caused by enterovirus 71.

J Med Virol 2019 Apr 3. Epub 2019 Apr 3.

Department of Intensive Care Unit, Xuzhou Children's Hospital of Xuzhou Medical University, Xuzhou, China.

Brain dysfunction is a prerequisite for critical complications in children with hand, foot, and mouth disease (HFMD). Aquaporin 4 (AQP-4) may be involved in the pathological process of cerebral oedema and injury in children with severe and critical HFMD. This study aimed to assess the association of AQP-4 with the severity of enterovirus 71 (EV71)-associated HFMD. Read More

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http://dx.doi.org/10.1002/jmv.25475DOI Listing
April 2019
3 Reads

Role of innate lymphoid cells and dendritic cells in intradermal immunization of the enterovirus antigen.

NPJ Vaccines 2019 27;4:14. Epub 2019 Mar 27.

Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, 650118 Kunming, Yunnan China.

Enterovirus type 71 (EV71) and coxsackievirus A 16 (CA16) are the major pathogens of human hand, foot, and mouth disease (HFMD). In our previous study, intramuscular immunization with the inactivated EV71 vaccine elicited effective immunity, while immunization with the inactivated CA16 vaccine did not. In this report, we focused on innate immune responses elicited by inactivated EV71 and CA16 antigens administered intradermally or intramuscularly. Read More

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http://www.nature.com/articles/s41541-019-0108-6
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http://dx.doi.org/10.1038/s41541-019-0108-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437170PMC
March 2019
5 Reads

A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence.

Sci Rep 2019 Apr 1;9(1):5427. Epub 2019 Apr 1.

Division of Biomedical & Life Sciences, Faculty of Health & Medicine, Lancaster University, Lancaster, LA1 4YT, UK.

Enterovirus A71 (EV-A71) is an emerging pathogen in the Enterovirus A species group. EV-A71 causes hand, foot and mouth disease (HFMD), with virulent variants exhibiting polio-like acute flaccid paralysis and other central nervous system manifestations. We analysed all enterovirus A71 complete genomes with collection dates from 2008 to mid-2018. Read More

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http://www.nature.com/articles/s41598-019-41662-8
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http://dx.doi.org/10.1038/s41598-019-41662-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443798PMC
April 2019
2 Reads

Impacts of tropical cyclones and accompanying precipitation and wind velocity on childhood hand, foot and mouth disease in Guangdong Province, China.

Environ Res 2019 Mar 21;173:262-269. Epub 2019 Mar 21.

Department of Epidemiology, School of Public Health, Shandong University, 44 West Wenhua Road, Jinan, Shandong, 250012, PR China; Shandong University Climate Change and Health Center, 44 West Wenhua Road, Jinan, Shandong, 250012, PR China. Electronic address:

Objective: Guangdong province is one of the provinces most frequently hit by tropical cyclones in China. Hand, foot and mouth disease (HFMD) continues to severely affect public health across the world. Our study aimed to evaluate the impacts of different grades of tropical cyclones and accompanying precipitation and wind velocity on HFMD among children younger than 6 years old in Guangdong province from 2009 to 2013. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00139351193016
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http://dx.doi.org/10.1016/j.envres.2019.03.041DOI Listing
March 2019
3 Reads

Clinical characteristics and managements of severe hand, foot and mouth disease caused by enterovirus A71 and coxsackievirus A16 in Shanghai, China.

BMC Infect Dis 2019 Mar 27;19(1):285. Epub 2019 Mar 27.

Department of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China.

Background: Hand, foot and mouth disease (HFMD) is a transmissible infectious disease caused by human enteroviruses (EV). Here, we described features of children with severe HFMD caused by EV-A71 or coxsackievirus A16 (CV-A16) in Shanghai, China.

Methods: Severe EV-A71 or CV-A16 caused HFMD children admitted to the Xinhua Hospital from January 2014 and December 2016, were recruited retrospectively to the study. Read More

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http://dx.doi.org/10.1186/s12879-019-3878-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438032PMC
March 2019
1 Read

Characterization of lymphocyte subsets in peripheral blood cells of children with EV71 infection.

J Microbiol Immunol Infect 2019 Mar 14. Epub 2019 Mar 14.

Virus Laboratory, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 318 Renminzhong Road Yuexiu District, Guangzhou, 510120, China. Electronic address:

Background: Enterovirus 71 (EV71) is one of the major causative pathogens of hand, foot, and mouth disease (HFMD). Immune cells play a critical role in determining the outcomes of virus infection. We aimed to characterize the lymphocyte subsets and transcriptional levels of T lymphocytes-associated transcription factors in peripheral blood cells of children with EV71 infection. Read More

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http://dx.doi.org/10.1016/j.jmii.2019.03.001DOI Listing
March 2019
1 Read

Autophagy induced by enterovirus 71 regulates the production of IL-6 through the p38MAPK and ERK signaling pathways.

Microb Pathog 2019 Mar 23;131:120-127. Epub 2019 Mar 23.

Fenyang College of Shanxi Medical University, Fenyang, China; Graduate School of Shanxi Medical University, Taiyuan, China. Electronic address:

Enterovirus 71 (EV71) is the main causative agent of hand, foot, and mouth disease (HFMD), which has high morbidity and mortality. It mainly threatens children under six years of age. Because of a poor understanding of its pathogenesis, there are no effective drugs to control EV71 infection. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.03.028DOI Listing
March 2019
1 Read

Characteristics of enterovirus 71-induced cell death and genome scanning to identify viral genes involved in virus-induced cell apoptosis.

Virus Res 2019 May 22;265:104-114. Epub 2019 Mar 22.

Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College of Fudan University, Shanghai 200032, China; Laboratory of Medical Microbiology, Department of Medical Microbiology and Parasitology, Shanghai Medical College of Fudan University, 138 Yixueyuan R., Shanghai 200032, China. Electronic address:

Enterovirus 71 (EV71) causes hand-foot-and-mouth disease and severe neural complications in infants and young children. Viral pathogenesis is associated with virus-induced cell death and inflammatory cytokine production, which is usually correlated with the type of programmed cell death. EV71-infected cells were analyzed through microscopy, cell staining, and immunoblotting to determine the characteristics of EV71-induced cell death. Read More

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http://dx.doi.org/10.1016/j.virusres.2019.03.017DOI Listing
May 2019
2 Reads

A Novel Murine Model Expressing a Chimeric mSCARB2/hSCARB2 Receptor is Highly Susceptible to Oral Infection with Clinical Isolates of EV71.

J Virol 2019 Mar 20. Epub 2019 Mar 20.

Graduate Institute of Biomedical Science, Chang Gung University, Guishan, Taoyuan, Taiwan

EV71 infection is generally associated with hand-foot-mouth disease (HFMD), and may cause severe neurological disorders and even death. An effective murine oral infection model for studying the pathogenesis of various clinical EV71 isolates is lacking. We developed a transgenic mouse that expresses EV71 receptor, that is human scavenger receptor class B member 2 (hSCARB2), in a pattern highly similar to that of murine endogenous mSCARB2 protein. Read More

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http://dx.doi.org/10.1128/JVI.00183-19DOI Listing
March 2019
1 Read

Remaining challenges for prevention and control of hand, foot, and mouth disease.

Lancet Child Adolesc Health 2019 Mar 15. Epub 2019 Mar 15.

WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.

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http://dx.doi.org/10.1016/S2352-4642(19)30065-3DOI Listing

Satisfactory usage of kidneys from pediatric donors with severe hand foot mouth disease.

Pediatr Transplant 2019 Mar 18:e13386. Epub 2019 Mar 18.

Department of Urological Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, China.

No studies have reported making use of kidneys from pediatric donors with severe HFMD. Here, we retrospectively analyzed the feasibility and clinical effect of six cases of kidney transplantation from four pediatric donors with severe HFMD in our center between January 2014 and December 2016. The donors' age ranged from 6 months to 3 years and 11 months. Read More

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http://dx.doi.org/10.1111/petr.13386DOI Listing
March 2019
1 Read

Enterovirus A71 Phenotypes Causing Hand, Foot and Mouth Disease, Vietnam.

Emerg Infect Dis 2019 Apr;25(4):788-791

We investigated enterovirus A71-associated hand, foot and mouth disease in Vietnam and found that, after replacing subgenogroup C4 in 2013, B5 remained the leading cause of this disease. In contrast with previous observations, this switch did not result in an explosive outbreak, and B5 evolution was driven by negative selection. Read More

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http://dx.doi.org/10.3201/eid2504.181367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433038PMC
April 2019
1 Read

Genetic characterization and ex-vivo neutralization behavior of bluetongue virus serotype-16 recovered from apparently healthy goat.

Acta Trop 2019 Mar 12;194:13-22. Epub 2019 Mar 12.

Division of Biological standardization, Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, 243122, India.

Bluetongue virus (BTV) infects almost all the domestic and wild ruminants though the clinical disease is most commonly reported in sheep and some species of deer. Goat and cattle are the most common asymptomatic reservoir of the virus. Full genome sequencing and serological characterization of the virus isolates are emphasized for understanding the phylogenetic relationship and molecular epidemiology of bluetongue (BT). Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.03.018DOI Listing
March 2019
1 Read
2.270 Impact Factor

Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease.

Int J Mol Sci 2019 Mar 13;20(6). Epub 2019 Mar 13.

Centre for Virus and Vaccine Research, Sunway University, Bandar Sunway, Subang Jaya, Selangor 47500, Malaysia.

Hand, foot, and mouth disease (HFMD) commonly produces herpangina, but fatal neurological complications have been observed in children. Enterovirus 71 (EV-A71) and Coxsackievirus 16 (CV-A16) are the predominant viruses causing HFMD worldwide. With rising concern about HFMD outbreaks, there is a need for an effective vaccine against EV-A71 and CV-A16. Read More

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http://dx.doi.org/10.3390/ijms20061256DOI Listing
March 2019
2 Reads

Time-series modelling and forecasting of hand, foot and mouth disease cases in China from 2008 to 2018.

Epidemiol Infect 2019 Jan;147:e82

Department of Infectious Diseases,Kunshan Centers for Disease Control and Prevention,Jiangsu Province,China.

Seasonal autoregressive-integrated moving average (SARIMA) has been widely used to model and forecast incidence of infectious diseases in time-series analysis. This study aimed to model and forecast monthly cases of hand, foot and mouth disease (HFMD) in China. Monthly incidence HFMD cases in China from May 2008 to August 2018 were analysed with the SARIMA model. Read More

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http://dx.doi.org/10.1017/S095026881800362XDOI Listing
January 2019
2 Reads

Infection Control in Nursery Schools and Schools Using a School Absenteeism Surveillance System.

Tohoku J Exp Med 2019 03;247(3):173-178

Infectious Disease Surveillance Center, National Institute of Infectious Diseases.

Infection control in nursery schools and schools is important for community health and the health of children. In Japan, caregivers of children or students usually report the absence due to illness to their attending nurseries or schools, including symptoms and diagnosed diseases. The (Nursery) School Absenteeism Surveillance System, (N)SASSy, covers about 60% of schools and 40% of nurseries in Japan. Read More

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https://www.jstage.jst.go.jp/article/tjem/247/3/247_173/_art
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http://dx.doi.org/10.1620/tjem.247.173DOI Listing
March 2019
7 Reads

Essential role of enterovirus 2A protease in counteracting stress granule formation and the induction of type I interferon.

J Virol 2019 Mar 13. Epub 2019 Mar 13.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands

Most viruses have acquired mechanisms to suppress antiviral IFN-α/β and stress responses. Enteroviruses actively counteract the induction of IFN-α/β gene transcription and stress granule (SG) formation, which are increasingly implicated as a platform for antiviral signaling, but the underlying mechanisms remain poorly understood. Both viral proteases (2A and 3C) have been implicated to suppress these responses, but these conclusions predominantly rely on ectopic overexpression of viral proteases or addition of purified viral proteases to cell lysates. Read More

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http://dx.doi.org/10.1128/JVI.00222-19DOI Listing
March 2019
6 Reads

APOBEC3G is a restriction factor of EV71 and mediator of IMB-Z antiviral activity.

Antiviral Res 2019 May 9;165:23-33. Epub 2019 Mar 9.

Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, 100050, China. Electronic address:

Enterovirus 71 (EV71), a single-stranded positive-sense RNA virus, is the causative agent of hand, foot, and mouth disease (HFMD), for which no effective antiviral therapy is currently available. Apolipoprotein B messenger RNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G or A3G) is a cytidine deaminase that inhibits the replication of several viruses, such as human immunodeficiency virus-1, hepatitis B virus and hepatitis C virus. In our efforts toward understanding the antiviral spectrum and mechanism of A3G, we found that ectopic expression of A3G inhibited EV71 replication, whereas knockdown of endogenous A3G expression promoted EV71 replication. Read More

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http://dx.doi.org/10.1016/j.antiviral.2019.03.005DOI Listing
May 2019
4 Reads
3.938 Impact Factor

Synthesis and Broad Antiviral Activity of Novel 2-aryl-isoindolin-1-ones towards Diverse Enterovirus A71 Clinical Isolates.

Molecules 2019 Mar 11;24(5). Epub 2019 Mar 11.

CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Tiantanxili, Beijing 100050, China.

Enterovirus 71 (EV-A71) is the main causative pathogen of childhood hand, foot and mouth disease. Effective medicine is currently unavailable for the treatment of this viral disease. Using the fragment-hopping strategy, a series of 2-aryl-isoindolin-1-one compounds were designed, synthesized and investigated for their in vitro antiviral activity towards multiple EV-A71 clinical isolates (H, BrCr, Shenzhen98, Jiangsu52) in Vero cell culture in this study. Read More

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http://dx.doi.org/10.3390/molecules24050985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429200PMC
March 2019
3 Reads
2.416 Impact Factor

Hand, foot and mouth disease caused by Coxsackie viruses A6 and A16 in Assam, Northeast India: A need for surveillance.

Indian J Dermatol Venereol Leprol 2019 Mar 12. Epub 2019 Mar 12.

Regional Virus Research Diagnostic Laboratory, ICMR-Regional Medical Research Centre, N.E.Region, Dibrugarh, Assam, India.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_576_17DOI Listing
March 2019
2 Reads

Interactions Between Enteroviruses and the Inflammasome: New Insights Into Viral Pathogenesis.

Front Microbiol 2019 25;10:321. Epub 2019 Feb 25.

NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Enteroviruses (EVs) have emerged a substantial threat to public health. EVs infection range from mild to severe disease, including mild respiratory illness, diarrhea, poliomyelitis, hand, foot, and mouth disease, aseptic meningitis, and encephalitis. In the Asia-Pacific region, for example, one of the best studied enterovirus 71 (EV71) has been associated with pandemics of hand, foot, and mouth disease (HFMD) in children, particularly those under the age of five. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398425PMC
February 2019
2 Reads

Type III interferon signaling restricts enterovirus 71 infection of goblet cells.

Sci Adv 2019 Mar 6;5(3):eaau4255. Epub 2019 Mar 6.

Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Recent worldwide outbreaks of enterovirus 71 (EV71) have caused major epidemics of hand, foot, and mouth disease with severe neurological complications, including acute flaccid paralysis. EV71 is transmitted by the enteral route, but little is known about the mechanisms it uses to cross the human gastrointestinal tract. Using primary human intestinal epithelial monolayers, we show that EV71 infects the epithelium from the apical surface, where it preferentially infects goblet cells. Read More

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http://advances.sciencemag.org/lookup/doi/10.1126/sciadv.aau
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http://dx.doi.org/10.1126/sciadv.aau4255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402847PMC
March 2019
14 Reads

Antiviral activity of sophoridine against enterovirus 71 in vitro.

J Ethnopharmacol 2019 May 7;236:124-128. Epub 2019 Mar 7.

Handan Municipal Center for Disease Control and Prevention, Hebei, 056000, China. Electronic address:

Ethnopharmacological Relevance: Enterovirus 71 (EV71) has a propensity to cause hand-foot-and-mouth disease (HFMD) epidemics associated with neurological sequelae. Unfortunately, no drugs are currently available for the clinical treatment of EV71 infections. Sophoridine (SRI) is one of the most abundant alkaloids in Sophora flavescens Aiton (Leguminosae), which has been used to treat fever, throat inflammation, cancer, and other diseases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03788741183483
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http://dx.doi.org/10.1016/j.jep.2019.02.045DOI Listing
May 2019
6 Reads

Epidemiologic features of enterovirus associated with hand, foot and mouth disease in 2013 and 2014 in Shenzhen, China.

Sci Rep 2019 Mar 7;9(1):3856. Epub 2019 Mar 7.

Department of Epidemiology, The Key Laboratory of Public Health Safety of Minister of Education, School of Public Health, Fudan University, Shanghai, 200032, China.

Hand, foot and mouth disease (HFMD) is responsible for a heavy economic and social burden in the Asia-Pacific region. Previous studies have shown that coxsackievirus A6 (CVA6) and coxsackievirus A10 (CVA10) have become the predominant agents of HFMD in mainland China in recent years, replacing enterovirus 71 (EV71) and coxsackievirus A16 (CVA16), although it is unclear if this is consistent throughout China. In this study, samples from 253 HFMD cases were collected in Shenzhen, China, from May 2013 through April 2014 to identify the etiological agent of HFMD. Read More

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http://dx.doi.org/10.1038/s41598-019-40402-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405776PMC
March 2019
3 Reads

Efficient expression of enterovirus 71 based on virus-like particles vaccine.

PLoS One 2019 7;14(3):e0210477. Epub 2019 Mar 7.

Division of Vaccine Research, Center for Infectious Diseases, Korea National Institutes of Health, Korea Centers for Disease Control and Prevention, Osong-eup, Cheongju, Chungcheongbuk-do, Republic of Korea.

Enterovirus (EV) 71 is the main pathogen associated with hand-foot-mouth disease (HFMD) and can lead to the disease with severe mortality in children. Since 2009, in the Republic of Korea, an outbreak of EV71 C4a infection with neurologic involvement emerged, where in HFMD involvement was identified and central nervous system complications were reported. In this study, EV71 C4a virus-like particles (VLPs) produced by recombinant technology were generated in a baculovirus expression system. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210477PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405078PMC
March 2019
5 Reads

[Post-marketing safety analysis of inactivated enterovirus A71 vaccines].

Zhonghua Yu Fang Yi Xue Za Zhi 2019 Mar;53(3):262-266

Institute for Immunization and Prevention, Zhejiang Provincial Center of Disease Control and Prevention, Hangzhou 310051, China.

To evaluate the safety of inactivated enterovirus A71(EV-A71) vaccines after large-scale immunization in the community. We selected EV-A71 susceptible people (healthy children) aged 6-59 months in vaccination clinics from 89 counties in Zhejiang Province between April 2016 and March 2018. All local and systematic adverse actions were collected by 30 min on-site inspection, within 3 days and 4-30 days follow-up. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2019.03.005DOI Listing
March 2019
5 Reads

[Post-marketing observation on safety of inactivated enterovirus A71 vaccine (human diploid cell)].

Zhonghua Yu Fang Yi Xue Za Zhi 2019 Mar;53(3):258-261

Department of Immunization Program, Zhejiang Provincal Center for Disease Control and Prevention, Hangzhou 310051, China.

To evaluate the post-marketing safety of inactivated Enterovirus type 71 (EV-A71) vaccine (human diploid cell) . A total of 20 191 healthy children aged 6 to 59 months were invited to receive 2 doses of EV-A71 vaccine in Zhejiang Province from September 2016 to December 2017. Child caregivers were followed up on the 4(th) or 5(th) day after each EV-A71 vaccination, and the incidence of local, systemic, and other adverse events within 3 days after vaccination was recorded to assess vaccine safety. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2019.03.004DOI Listing
March 2019
5 Reads

Near-Complete Genome Sequences of 12 Coxsackievirus Group A Strains from Hand, Foot, and Mouth Disease and Herpangina Cases with Different Clinical Symptoms.

Microbiol Resour Announc 2019 Feb 21;8(8). Epub 2019 Feb 21.

District Key Laboratory for Infectious Disease Prevention and Control, Longhua Center for Disease Control and Prevention, Shenzhen, China.

Coxsackievirus group A (CV-A) strains are important pathogens of hand, foot, and mouth disease and herpangina. We report here the near-complete genome sequences of 12 CV-A strains isolated from infants and children with different clinical diseases. The presented data will be very useful for future genome-based epidemiological studies. Read More

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http://dx.doi.org/10.1128/MRA.01655-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386572PMC
February 2019
1 Read

Preparation and identification of chicken egg yolk immunoglobulins against human enterovirus 71 for diagnosis of hand-foot-and-mouth disease.

Anal Biochem 2019 May 1;573:44-50. Epub 2019 Mar 1.

School of Public Health, Jilin University, Changchun, Jilin, China.

Human enterovirus 71 (EV71) is one of the major pathogens that causes hand-foot-and mouth disease, and there is an urgent need for rapid diagnosis of EV71 virus infection for early antiviral treatment. The aim of this study was to prepare chicken egg yolk immunoglobulin Y (IgY) for the diagnosis of enterovirus type 71 infection. The antibodies were raised by intramuscular immunization of laying hens with inactivated human EV71 and isolated from the egg yolk by multiple steps of polyethylene glycol 6000 extraction. Read More

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http://dx.doi.org/10.1016/j.ab.2019.02.029DOI Listing
May 2019
3 Reads

Analysis of the effect of PM10 on hand, foot and mouth disease in a basin terrain city.

Sci Rep 2019 Mar 1;9(1):3233. Epub 2019 Mar 1.

West China School of Public Health, Sichuan University, Chengdu, Sichuan, People's Republic of China.

Hand, foot, and mouth disease (HFMD) is a common childhood infection that causes a substantial disease burden in the Asia-Pacific region. Various climate variables, such as humidity and temperature, have been associated with HFMD. However, few studies have assessed the impact of PM on childhood HFMD. Read More

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http://dx.doi.org/10.1038/s41598-018-35814-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397224PMC
March 2019
2 Reads

Saikosaponin D suppresses enterovirus A71 infection by inhibiting autophagy.

Signal Transduct Target Ther 2019 22;4. Epub 2019 Feb 22.

1School of Biomedical Sciences, University of Hong Kong, Hong Kong, China.

The dysregulation of autophagy, an evolutionarily conserved lysosomal degradation process, has been implicated in a wide variety of human diseases, and thus, small chemicals that modulate autophagy have therapeutic potential. Here, we assessed the ability of active components isolated from , a popular Chinese herb, to modulate autophagy. We found that saikosaponin D (SsD) and A (SsA) but not C (SsC) potently and reversibly inhibited the fusion of autophagosomes and lysosomes, resulting in the accumulation of autophagosomes, an increased lysosomal pH, and TFEB nuclear translocation. Read More

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http://dx.doi.org/10.1038/s41392-019-0037-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385247PMC
February 2019
6 Reads

Recombinant virus-like particle presenting a newly identified coxsackievirus A10 neutralization epitope induces protective immunity in mice.

Antiviral Res 2019 Apr 25;164:139-146. Epub 2019 Feb 25.

Vaccine Research Center, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China; Joint Center for Infection and Immunity, Guangzhou Institute of Pediatrics, Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. Electronic address:

Coxsackievirus A10 (CVA10) has emerged as one of the major pathogens of hand, foot, and mouth disease in recent years. However, there are no approved vaccines or effective drugs against CVA10. Several experimental CVA10 vaccines have been shown to elicit neutralizing antibodies that could confer protection against viral infection. Read More

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http://dx.doi.org/10.1016/j.antiviral.2019.02.016DOI Listing
April 2019
3 Reads
3.938 Impact Factor

Identification of SAA and ACTB as potential biomarker of patients with severe HFMD using iTRAQ quantitative proteomics.

Clin Biochem 2019 May 25;67:1-6. Epub 2019 Feb 25.

Fujian Medical University Teaching Hospital, First Hospital of Putian, China.

Hand, foot and mouth disease (HFMD) is an infectious disease caused by a variety of enterovirus infections, and the most common types of virus infections are the newenterovirus71 (EV71) and coxsackievirus A group 16 (CoxA16). A small fraction of HFMD will cause further severe HFMD. A rapid and accurate diagnosis biomarker of severe HFMD is important for the timely treatment. Read More

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http://dx.doi.org/10.1016/j.clinbiochem.2019.02.011DOI Listing
May 2019
2 Reads

Hsp27 Responds to and Facilitates Enterovirus A71 Replication by Enhancing Viral Internal Ribosome Entry Site-Mediated Translation.

J Virol 2019 May 17;93(9). Epub 2019 Apr 17.

Department of Biomedical Sciences, City University of Hong Kong, Kowloon, Hong Kong

Enterovirus 71 (EV-A71) is a human pathogen that causes hand, foot, and mouth disease (HFMD) and fatal neurological diseases, and no effective treatment is available. Characterization of key host factors is important for understanding its pathogenesis and developing antiviral drugs. Here we report that Hsp27 is one of the most upregulated proteins in response to EV-A71 infection, as revealed by two-dimensional gel electrophoresis-based proteomics studies. Read More

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http://jvi.asm.org/lookup/doi/10.1128/JVI.02322-18
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http://dx.doi.org/10.1128/JVI.02322-18DOI Listing
May 2019
9 Reads
4.439 Impact Factor

Association of IL-13, S100B, and TLR-7 Gene Polymorphisms with Enterovirus 71 Infection in Hand, Foot, and Mouth Disease in China.

Genet Test Mol Biomarkers 2019 Mar 26;23(3):188-196. Epub 2019 Feb 26.

2 Department of Hyperbaric Oxygenation, Dongying People's Hospital, Dongying, China.

Aim: This study was conducted to determine if single nucleotide polymorphisms within the interleukin (IL)-13 (rs20541 locus), the S100B (rs9722 locus), and the toll-like receptor (TLR)-7 (rs179019 and rs3853839 loci) genes are associated with the clinical severity of disease caused by enterovirus 71 (EV71) in children suffering from hand, foot, and mouth disease (HFMD).

Materials And Methods: A total of 355 children, diagnosed with HFMD, were divided into two groups: severe (totaling 162 cases) and mild (totaling 193 cases). Three hundred healthy children were recruited as a control group. Read More

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http://dx.doi.org/10.1089/gtmb.2018.0239DOI Listing
March 2019
3 Reads

Real-Time Forecasting of Hand-Foot-and-Mouth Disease Outbreaks using the Integrating Compartment Model and Assimilation Filtering.

Sci Rep 2019 Feb 25;9(1):2661. Epub 2019 Feb 25.

Faculty of Geo-Information Science and Earth Observation (ITC), University of Twente, Enschede, 7500, The Netherlands.

Hand-foot-and-mouth disease (HFMD) is a highly contagious viral infection, and real-time predicting of HFMD outbreaks will facilitate the timely implementation of appropriate control measures. By integrating a susceptible-exposed-infectious-recovered (SEIR) model and an ensemble Kalman filter (EnKF) assimilation method, we developed an integrated compartment model and assimilation filtering forecast model for real-time forecasting of HFMD. When applied to HFMD outbreak data collected for 2008-11 in Beijing, China, our model successfully predicted the peak week of an outbreak three weeks before the actual arrival of the peak, with a predicted maximum infection rate of 85% or greater than the observed rate. Read More

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http://dx.doi.org/10.1038/s41598-019-38930-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389963PMC
February 2019

Identifying risk factors for neurological complications and monitoring long-term neurological sequelae: protocol for the Guangzhou prospective cohort study on hand-foot-and-mouth disease.

BMJ Open 2019 Feb 24;9(2):e027224. Epub 2019 Feb 24.

Department of Infectious Diseases, Guangzhou Women and Children's Medical Center, Guangzhou, China.

Introduction: Hand-foot-and-mouth disease (HFMD) is a paediatric infectious disease that is particularly prevalent in China. Severe HFMDs characterised by neurological involvement are fatal and survivors who have apparently fully recovered might still be afflicted later in life with neurocognitive impairments. Only when a well-designed, prospective cohort study is in place can we develop clinical tools for early warning of neurological involvement and can we obtain epidemiological evidence regarding the lingering effects of the sequelea. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443074PMC
February 2019
2 Reads
2.063 Impact Factor

Developing a Nomogram for Risk Prediction of Severe Hand-Foot-and-Mouth Disease in Children.

Indian J Pediatr 2019 Apr 23;86(4):365-370. Epub 2019 Feb 23.

Department of Gastroenterology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Objective: Early recognition of children with severe Hand-Foot-and-Mouth disease (HFMD) is especially important, as severe cases are associated with poor prognosis. To accomplish this, authors designed a quantitative assessment tool to build a nomogram to assist in clinical diagnosis.

Methods: A total of 2332 HFMD patients were enrolled in this study; 1750 cases in the mild group and 582 cases in the severe group. Read More

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http://link.springer.com/10.1007/s12098-019-02898-4
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http://dx.doi.org/10.1007/s12098-019-02898-4DOI Listing
April 2019
9 Reads
0.919 Impact Factor

Polypyrimidine Tract-Binding Protein Regulates Enterovirus 71 Translation Through Interaction with the Internal Ribosomal Entry Site.

Virol Sin 2019 Feb 22;34(1):66-77. Epub 2019 Feb 22.

Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College, Kunming, 650118, China.

Enterovirus 71 (EV71), a major causative agent of hand, foot, and mouth disease, has caused periodic infection outbreaks in children in the Asia-Pacific region. In order to describe the largely unknown life cycle of EV71, the molecular basis of its virus-host interactions must first be determined. The 5' untranslated region of EV71 contains a cloverleaf-like structure and internal ribosomal entry site (IRES), which play an important role in transcription and translation of viral protein. Read More

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http://dx.doi.org/10.1007/s12250-019-00089-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420457PMC
February 2019
2 Reads

Hand, foot, and mouth disease associated with coxsackievirus A10: more serious than it seems.

Expert Rev Anti Infect Ther 2019 Apr 6;17(4):233-242. Epub 2019 Mar 6.

a Division of Hepatitis Virus Vaccines , National Institutes for Food and Drug Control , Beijing , China.

Introduction: Hand, foot, and mouth disease (HFMD) is a common viral childhood illness, that has been a severe public health concern worldwide, particularly in the Asia-Pacific region. According to epidemiological data of HFMD during the past decade, the most prevalent causal viruses were enterovirus (EV)-A71, coxsackievirus (CV)-A16, CV-A6, and CV-A10. The public health burden of CV-A10-related diseases has been underestimated as their incidence was lower than that of EV-A71 and CV-A16 in most HFMD outbreaks. Read More

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https://www.tandfonline.com/doi/full/10.1080/14787210.2019.1
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http://dx.doi.org/10.1080/14787210.2019.1585242DOI Listing
April 2019
10 Reads

Molecular Epidemiology of Echovirus 18 Circulating in Mainland China from 2015 to 2016.

Virol Sin 2019 Feb 21;34(1):50-58. Epub 2019 Feb 21.

Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Virology Laboratory, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

Echovirus 18 (E18), a serotype of Enterovirus B (EV-B) species, is an important pathogen in aseptic meningitis. E18 had rarely been detected in mainland China, but became the predominant pathogen associated with viral encephalitis (VE) and meningitis in Hebei province for the first time in 2015. To investigate the molecular epidemiology and genetic characteristics of E18 in mainland China, sixteen E18 strains from patient throat swabs with hand, foot, and mouth disease (HFMD) in six provinces in China collected between 2015 and 2016, and four E18 strains isolated from 18 patient cerebrospinal fluid specimens with VE in Hebei Province in 2015 were obtained and sequenced. Read More

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http://dx.doi.org/10.1007/s12250-018-0080-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420525PMC
February 2019
3 Reads

Molecular epidemiology of an enterovirus A71 outbreak associated with severe neurological disease, Spain, 2016.

Euro Surveill 2019 Feb;24(7)

Translational Research Network in Paediatric Infectious Diseases (RITIP), IdiPaz, Madrid, Spain.

IntroductionEnterovirus A71 (EV-A71) is an emerging pathogen that causes a wide range of disorders including severe neurological manifestations. In the past 20 years, this virus has been associated with large outbreaks of hand, foot and mouth disease with neurological complications in the Asia-Pacific region, while in Europe mainly sporadic cases have been reported. In spring 2016, however, an EV-A71 outbreak associated with severe neurological cases was reported in Catalonia and spread further to other Spanish regions. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.7.1800089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381658PMC
February 2019
6 Reads