2,694 results match your criteria Hand-Foot-and-Mouth Disease


Mosaic genome of Human Coxsackievirus A4 associated with herpangina and HFMD in Yancheng, China, 2016 and 2018.

Int J Infect Dis 2020 May 18. Epub 2020 May 18.

Yancheng Center for Disease Control and Prevention, Yancheng, Jiangsu, China. Electronic address:

Objectives: To better understand the spectrums of pathogens causing herpangina and circulation of Coxsackievirus A4 in Yancheng, China.

Methods: Stool samples from herpangina and HFMD cases were collected. Real Time PCR Kits was used to identify Enterovirus 71, CV-A16 and CV-A6, and nested reverse transcription PCR (nRT-PCR) to detect the other enterovirus types. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.05.057DOI Listing

Viral Exanthem with "Pin and Needles Sensation" on Extremities of COVID-19 Patient.

Int J Infect Dis 2020 May 8. Epub 2020 May 8.

Department of Cardiology and Vascular Medicine, National Cardiovascular Centre Harapan Kita, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.

Cutaneous manifestation is a newly reported clinical manifestation of COVID-19 infection. The clinical description of cutaneous manifestation is still not fully described. Our patient, a medical personnel, had viral exanthem distributed in the extremities along with "pin and needles sensation" which differ from the previously published paper on cutaneous manifestation. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207113PMC

Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation.

Virulence 2020 Dec;11(1):537-553

State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.

Enterovirus 71 (EV71) infection causes hand, foot, and mouth disease (HFMD), and even fatal neurological complications. However, the mechanisms underlying EV71 neurological pathogeneses are largely unknown. This study reveals a distinct mechanism by which EV71 induces apoptosis and autophagy in neural cells. Read More

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http://dx.doi.org/10.1080/21505594.2020.1766790DOI Listing
December 2020

Epidemiology of Hand, Foot, and Mouth Disease Before and After the Introduction of Enterovirus 71 Vaccines in Chengdu, China, 2009-2018.

Pediatr Infect Dis J 2020 May 19. Epub 2020 May 19.

Department of Epidemiology and Biostatitics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Sichuan, China.

Background: Hand, foot, and mouth disease (HFMD) has posed a serious threat to children's health. Three inactivated monovalent enterovirus 71 (EV71) vaccines are proved to be highly efficacious in phase III clinical trials and are now available in China.

Methods: We analyzed the citywide surveillance data on HFMD cases in Chengdu during 2009-2018, and estimated cumulative first-dose EV71 vaccination coverage among children eligible to EV71 vaccination after August 2016 in Chengdu. Read More

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http://dx.doi.org/10.1097/INF.0000000000002745DOI Listing

Severity detection tool for patients with infectious disease.

Healthc Technol Lett 2020 Apr 14;7(2):45-50. Epub 2020 Apr 14.

Institute of Biomedical Engineering, University of Oxford, Oxford, UK.

Hand foot and mouth disease (HFMD) and tetanus are serious infectious diseases in low- and middle-income countries. Tetanus, in particular, has a high mortality rate and its treatment is resource-demanding. Furthermore, HFMD often affects a large number of infants and young children. Read More

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http://dx.doi.org/10.1049/htl.2019.0030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199289PMC

Association between platelet count and the risk and progression of hand, foot, and mouth disease among children.

Clinics (Sao Paulo) 2020 15;75:e1619. Epub 2020 May 15.

Department of Pediatrics, The First Affiliated Hospital of Kangda College of Nanjing Medical University /, First People's Hospital of Lianyungang, Lianyungang, China.

Objective: We aimed to evaluate the association between platelet (PLT) count and the risk and progression of hand, foot, and mouth disease (HFMD).

Methods: In total, 122 HFMD patients and 40 healthy controls were enrolled in the study. The differences between variables among the different subgroups were compared. Read More

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http://dx.doi.org/10.6061/clinics/2020/e1619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213664PMC

Drug repurposing of pyrimidine analogs as potent antiviral compounds against human enterovirus A71 infection with potential clinical applications.

Sci Rep 2020 May 18;10(1):8159. Epub 2020 May 18.

Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, MD4 Level 5, 5 Science Drive 2, Singapore, 117597, Singapore.

Enterovirus A71 (EV-A71) is one of the aetiological agents for the hand, foot and mouth disease (HFMD) in young children and a potential cause of neurological complications in afflicted patients. Since its discovery in 1969, there remains no approved antiviral for EV-A71 and other HFMD-causing enteroviruses. We set out to address the lack of therapeutics against EV-A71 by screening an FDA-approved drug library and found an enrichment of hits including pyrimidine antimetabolite, gemcitabine which showed 90. Read More

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http://dx.doi.org/10.1038/s41598-020-65152-4DOI Listing

WHO working group meeting to develop WHO Recommendations to assure the quality, safety and efficacy of enterovirus 71 vaccines.

Vaccine 2020 May 4. Epub 2020 May 4.

National Institute for Biological Standards and Control, United Kingdom.

Enterovirus A71 (EV71) is one of the major causative agents of hand, foot and mouth disease (HFMD), and is sometimes associated with severe central nervous system syndromes. Vaccines against EV71 infection have been developed or are in development in several countries and few have been licensed in China. In response to requests from some of these countries, WHO convened a working group meeting in Shanghai China from 11 to 12 September 2019 to develop WHO Recommendations to assure the quality, safety and efficacy of EV71 vaccines. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.05.001DOI Listing

Are Italy and Iran really suffering from COVID-19 epidemic? A controversial study.

Eur Rev Med Pharmacol Sci 2020 04;24(8):4519-4522

Faculty of Engineering and Architecture, Istanbul Gelisim University, Istanbul, Turkey.

The number of global COVID-19 infected cases is increased rapidly to exceed 370 thousand. COVID-19 is transmitted between humans through direct contact and touching dirty surfaces. This paper aims to find the similarity between DNA sequences of COVID-19 in different countries, and to compare these sequences with three different diseases [HIV, Hand-Foot-Mouth disease (HFMD), and Cryptococcus]. Read More

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http://dx.doi.org/10.26355/eurrev_202004_21034DOI Listing

Quantifying the risk of hand, foot, and mouth disease (HFMD) attributable to meteorological factors in East China: A time series modelling study.

Sci Total Environ 2020 Apr 19;728:138548. Epub 2020 Apr 19.

Department of Epidemiology and Biostatistics, School of Public Health, Fudan University, 138 Yixueyuan Rd, Xuhui District, Shanghai, China; Key Laboratory of Public Health Safety, Ministry of Education, 138 Yixueyuan Rd, Xuhui District, Shanghai, China. Electronic address:

Background: Hand, foot, and mouth disease (HFMD) is a widespread infectious disease in China. Associated meteorological factors have been widely studied, but their attributable risks have not been well quantified.

Objectives: The study aimed to quantify the HFMD burden attributable to temperature and other meteorological factors. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.138548DOI Listing

Coxsackievirus A16 in a 1-Day-Old Mouse Model of Central Nervous System Infection Shows Lower Neurovirulence than Enterovirus A71.

J Comp Pathol 2020 Apr 4;176:19-32. Epub 2020 Mar 4.

Department of Pathology, University of Malaya, Kuala Lumpur, Malaysia. Electronic address:

Coxsackievirus A16 (CV-A16) and enterovirus A71 (EV-A71) are the major causes of hand, foot and mouth disease in young children. Although less so with CV-A16, both viruses are associated with serious neurological syndromes, but the differences between their central nervous system infections remain unclear. We conducted a comparative infection study using clinically-isolated CV-A16 and EV-A71 strains in a 1-day-old mouse model to better understand the neuropathology and neurovirulence of the viruses. Read More

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http://dx.doi.org/10.1016/j.jcpa.2020.02.001DOI Listing

Epitope Peptide Amphiphile-Based Nanofiber as an Effective Vaccine for Viral Infectious Diseases.

J Nanosci Nanotechnol 2020 Sep;20(9):5329-5332

College of Pharmacy, Ajou University, Suwon 16499, Republic of Korea.

Peptide-based vaccines are relatively safe but have weak immune responses even with an adjuvant. In order to overcome the limitations of peptide-based vaccines, we developed peptide amphiphile (PA)-based nanofibers to enhance the immune responses for preventing enterovirus 71 (EV71) infectious disease (i.e. Read More

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http://dx.doi.org/10.1166/jnn.2020.17655DOI Listing
September 2020

Genome Sequence of a Human Coxsackievirus A6 Strain Isolated from a Severe Hand, Foot, and Mouth Disease Case in Qingdao, China, in 2017.

Microbiol Resour Announc 2020 Apr 23;9(17). Epub 2020 Apr 23.

School of Public Health, Qingdao University, Qingdao, China

In the present study, we describe the genome sequence of coxsackievirus A6 (CVA6) strain 17ES4/QD/CHN/2017, which was isolated in Qingdao, China, in 2017. According to the phylogenetic analyses, the isolate belongs to subgenotype D3a. Read More

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http://dx.doi.org/10.1128/MRA.01449-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180285PMC

Immunization with a fusion protein vaccine candidate generated from truncated peptides of human enterovirus 71 protects mice from lethal enterovirus 71 infections.

Virol J 2020 Apr 22;17(1):58. Epub 2020 Apr 22.

NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious Diseases, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Institute of Laboratory Animal Science, CAMS&PUMC, Beijing, 100021, People's Republic of China.

Background: Prophylactic vaccines are critical in preventing hand, foot, and mouth disease (HFMD) primarily caused by human enterovirus 71 (EV71) infection. Children aged less than 5 years are especially susceptible to EV71 infections. In addition to the development of vaccines containing the inactivated virus, those containing virus-like particles (VLPs) with repeated antigens also constitute an effective preventive strategy for EV71 infections, with safety and productivity advantages. Read More

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http://dx.doi.org/10.1186/s12985-020-01328-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178760PMC
April 2020
2.181 Impact Factor

Atypical hand-foot-mouth disease in Belém, Amazon region, northern Brazil, with detection of coxsackievirus A6.

J Clin Virol 2020 May 6;126:104307. Epub 2020 Mar 6.

Instituto Evandro Chagas, Health Surveillance Secretariat, Brazilian Ministry of Health, Belém, Brazil. Electronic address:

Background: Enterovirus (EV) A71 and coxsackievirus (CV) A16 were the most frequent serotypes involved in hand, foot, and mouth disease (HFMD) outbreaks throughout Asia. In the past 5 years, however, CV-A6 has emerged as a new important pathogen worldwide, and more severe and extensive dermatologic presentations has been reported.

Objectives: Identify the clinical spectrum for atypical HFMD and enterovirus serotypes in Belém, Pará, Amazon region of northern Brazil. Read More

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http://dx.doi.org/10.1016/j.jcv.2020.104307DOI Listing

Cardiopulmonary failure in children infected with Enterovirus A71.

J Biomed Sci 2020 Apr 16;27(1):53. Epub 2020 Apr 16.

Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, No. 5, Fuxing Street, Guishan District, Taoyuan, 333, Taiwan.

Enterovirus A71 (EV-A71) is one of the causative pathogens of hand, foot, and mouth disease (HFMD), which may cause severe neurological and cardiopulmonary complications in children. In this review, we discuss the pathogenesis, clinical manifestations, management strategy, and clinical outcomes of cardiopulmonary failure (CPF) in patients with EV-A71 infection.The pathogenesis of CPF involves both catecholamine-related cardiotoxicity following brainstem encephalitis and vasodilatory shock due to cytokine storm. Read More

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http://dx.doi.org/10.1186/s12929-020-00650-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161201PMC

Antiviral activity of silymarin in comparison with baicalein against EV-A71.

BMC Complement Med Ther 2020 Mar 23;20(1):97. Epub 2020 Mar 23.

Centre for Virus and Vaccine Research, Sunway University, Bandar Sunway, 47500, Subang Jaya, Selangor, Malaysia.

Background: The hand, foot and mouth disease (HFMD) is a febrile and exanthematous childhood disease mainly caused by Enterovirus 71 (EV-A71). In severe HFMD, virulent EV-A71 strains can cause acute flaccid paralysis and cardiopulmonary edema leading to death. Currently, no FDA approved antiviral treatment or vaccine is available for EV-A71. Read More

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http://dx.doi.org/10.1186/s12906-020-2880-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092479PMC

Temperature and hand, foot and mouth disease in California: An exploratory analysis of emergency department visits by season, 2005-2013.

Environ Res 2020 Jun 30;185:109461. Epub 2020 Mar 30.

Air and Climate Epidemiology Section, Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, CA, United States.

Background: For the past decade, hand, foot and mouth disease (HFMD), caused by entero and coxsackie viruses, has been spreading in Asia, particularly among children, overloading healthcare settings and creating economic hardships for parents. Recent studies have found meteorological factors, such as temperature, are associated with HFMD in Asia. However, few studies have explored the relationship in the United States, although HFMD cases have steadily increased recently. Read More

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http://dx.doi.org/10.1016/j.envres.2020.109461DOI Listing

Integration of a Kalman filter in the geographically weighted regression for modeling the transmission of hand, foot and mouth disease.

BMC Public Health 2020 Apr 10;20(1):479. Epub 2020 Apr 10.

State Key Laboratory of Resources and Environmental Information System, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, China.

Background: Hand, foot and mouth disease (HFMD) is a common infectious disease whose mechanism of transmission continues to remain a puzzle for researchers. The measurement and prediction of the HFMD incidence can be combined to improve the estimation accuracy, and provide a novel perspective to explore the spatiotemporal patterns and determinant factors of an HFMD epidemic.

Methods: In this study, we collected weekly HFMD incidence reports for a total of 138 districts in Shandong province, China, from May 2008 to March 2009. Read More

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http://dx.doi.org/10.1186/s12889-020-08607-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146977PMC
April 2020
2.264 Impact Factor

Interaction between PHB2 and Enterovirus A71 VP1 Induces Autophagy and Affects EV-A71 Infection.

Viruses 2020 Apr 8;12(4). Epub 2020 Apr 8.

Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China.

Enterovirus A71 (EV-A71) is a major pathogen that causes severe and fatal cases of hand-foot-and-mouth disease (HFMD). HFMD caused by EV-A71 seriously endangers children's health. Although autophagy is an important antiviral defense mechanism, some viruses have evolved strategies to utilize autophagy to promote self-replication. Read More

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http://dx.doi.org/10.3390/v12040414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232526PMC

[Therapeutic effect of acupuncture on dysphagia in children with severe hand foot and mouth disease].

Zhongguo Zhen Jiu 2020 Apr;40(4):391-4

Henan Children's Hospital/Zhengzhou Children's Hospital, Zhengzhou 450046, China.

Objective: To observe the effect of acupuncture combined with conventional symptomatic and supportive treatments on swallowing function and nutritional status in children with severe hand foot and mouth disease complicated with dysphagia.

Methods: A total of 68 children with severe hand foot and mouth disease complicated with dysphagia were randomized into an observation group and a control group, 34 cases in each one. Symptomatic and supportive treatments such as lowering temperature, tranquilizing and mechanical ventilation were adopted in the control group. Read More

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http://dx.doi.org/10.13703/j.0255-2930.20190820-k0001DOI Listing

Epidemiological and aetiological characteristics of hand, foot, and mouth disease in Sichuan Province, China, 2011-2017.

Sci Rep 2020 Apr 9;10(1):6117. Epub 2020 Apr 9.

West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.

Hand, foot, and mouth disease (HFMD) remains a threat to the Asia-Pacific region. The epidemiological characteristics and pathogen spectrum of HFMD vary with space and time. These variations are crucial for HFMD interventions but poorly understood in Sichuan Province, China, particularly after the introduction of the EV-A71 vaccine. Read More

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http://dx.doi.org/10.1038/s41598-020-63274-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145801PMC

Co-circulation of coxsackieviruses A-6, A-10, and A-16 causes hand, foot, and mouth disease in Guangzhou city, China.

BMC Infect Dis 2020 Apr 7;20(1):271. Epub 2020 Apr 7.

Medical Genetic Centre, Guangdong Women and Children's Hospital, Guangzhou Medical University, Guangzhou, 511442, People's Republic of China.

Background: Hand, foot, and mouth disease (HFMD) is a common infectious disease occurring in children under 5 years of age worldwide, and Enterovirus A71 (EV-A71) and Coxsackievirus A16 (CVA-16) are identified as the predominant pathogens. In recent years, Coxsackievirus A6 (CVA-6) and Coxsackievirus A10 (CVA-10) have played more and more important role in a series of HFMD outbreaks. This study aimed to understand the epidemic characteristics associated with HFMD outbreak in Guangzhou, 2018. Read More

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http://dx.doi.org/10.1186/s12879-020-04992-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137261PMC

Development of a multivalent enterovirus subunit vaccine based on immunoinformatic design principles for the prevention of HFMD.

Vaccine 2020 Apr 2;38(20):3671-3681. Epub 2020 Apr 2.

Center of Pathogen Biology and Immunology, Department of Microbiology and Immunology, Shantou University Medical College, Shantou 505041, Guangdong, China; Guangdong Provincial Key Laboratory of Infectious Disease and Molecular Immunopathology, Shantou University Medical College, Shantou 505041, Guangdong, China. Electronic address:

Hand, foot and mouth disease (HFMD) is mainly caused by EV-A71 and CV-A16. An increasing number of cases have been found to be caused by CV-A10, CV-A6, CV-B3 and the outbreaks are becoming increasingly more complex, often accompanied by the prevalence of a variety of enteroviruses. Based on the principle of synthetic peptide vaccines, we applied immune-informatics to design a highly efficient and safe multivalent epitope-based vaccine against EV-A71, CV-A16, CV-A10, CV-A6 and CV-B3. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.03.023DOI Listing

Sodium Copper Chlorophyllin Is Highly Effective against Enterovirus (EV) A71 Infection by Blocking Its Entry into the Host Cell.

ACS Infect Dis 2020 May 10;6(5):882-890. Epub 2020 Apr 10.

Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.

Human enteroviruses (HEVs) pose an ongoing threat to global public health. Particularly, enterovirus-A71 (EV-A71), the main pathogen causing hand-foot-and-mouth disease (HFMD), has caused ongoing outbreaks globally in recent years associated with severe neurological manifestations and several deaths. Currently, no effective antivirals are available for the prevention or treatment of EV-A71 infection. Read More

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http://dx.doi.org/10.1021/acsinfecdis.0c00096DOI Listing

Transcriptome sequencing analysis of SH-SY5Y cells infected with EV71 reveals the potential neuropathic mechanisms.

Virus Res 2020 Jun 24;282:197945. Epub 2020 Mar 24.

Department of Respiratory Medicine, The First People's Hospital of Yunnan Province, Kunming, 650022, China. Electronic address:

Enterovirus A71 (EV71) remains the most common causative agent of hand, foot, and mouth disease (HFMD), and the neurological complications induced by EV71 are usually the leading cause of death in children with HFMD. However, the mechanism of nervous system changes caused by EV71 infection is still unclear. Therefore, in the current study, EV71 was inoculated into the human neuroblastoma cell line SH-SY5Y and subsequent transcriptome sequencing was used to examine the alterations of the transcriptome in infected SH-SY5Y cells. Read More

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http://dx.doi.org/10.1016/j.virusres.2020.197945DOI Listing

Willingness of parents to vaccinate their 6-60-month-old children with EV71 vaccines: a cross-sectional study in rural areas of northern Jiangsu Province.

Hum Vaccin Immunother 2020 Mar 25:1-7. Epub 2020 Mar 25.

School of Public Health, Nanjing Medical University, Nanjing, PR China.

Enterovirus 71 (EV71) is the dominant pathogen in severe and fatal hand-foot-mouth disease (HFMD) cases. Since 2015, three inactivated EV71 vaccines have been approved in China. The vaccination coverage of the EV71 vaccine has been relatively low, especially in rural areas. Read More

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http://dx.doi.org/10.1080/21645515.2020.1737465DOI Listing

The modification effect of the diurnal temperature range on the exposure-response relationship between temperature and pediatric hand, foot and mouth disease.

Sci Total Environ 2020 Jun 13;722:137921. Epub 2020 Mar 13.

Division of Infectious Disease & Key Laboratory of Surveillance and Early Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China.

Background: Growing evidence suggests that the diurnal temperature range (DTR) could modify the temperature-disease relationship for those environmentally-related infectious diseases. However, there is a lack of evidence on the hand, foot and mouth disease (HFMD). In this study, we thoroughly examined this hypothesis via a nationwide study. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.137921DOI Listing

Isolation and molecular characterization of coxsackievirus A6 and coxsackievirus A16 from a case of recurrent Hand, Foot and Mouth Disease in Mumbai, Maharashtra, India, 2018.

Virusdisease 2020 Mar 7;31(1):56-60. Epub 2020 Feb 7.

Mendadkar Children's Hospital, Kurla, Mumbai, 400024 India.

Hand, Foot and Mouth Disease (HFMD) is caused by multiple Enterovirus (EV) serotypes mainly coxsackievirus A6 (CV-A6), coxsackievirus A16 (CV-A16) and Enterovirus 71 (EV-A71). Recurrent HFMD infections are rarely reported. An unusual rise in HFMD cases was reported in Mumbai during May-June 2018. Read More

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http://dx.doi.org/10.1007/s13337-020-00567-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085487PMC

[Atypical hand-foot-mouth disease virus genotyping in a pediatric hospital in Buenos Aires city, Argentina].

Arch Argent Pediatr 2020 04;118(2):e199-e203

Laboratorio de Virología, Hospital de Niños Dr. Ricardo Gutiérrez, Buenos Aires, Argentina.

Typical hand-foot-mouth disease (HFMD) is an exanthematous viral disease with a classic symptomatology of fever, papulovesicular rash on the hands and feet with or without herpangina. It is usually caused by enterovirus 71 and Coxsackievirus A16, members of the genus Enterovirus. Recently, worldwide outbreaks of HFMD with atypical manifestations caused by Coxsackievirus A6 have been described. Read More

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http://dx.doi.org/10.5546/aap.2020.e199DOI Listing

The rash with mucosal ulceration.

Clin Dermatol 2020 Jan - Feb;38(1):35-41. Epub 2019 Oct 25.

Sector of Dermatology and Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Brazil. Electronic address:

A rash is a disseminated eruption of cutaneous lesions with great variation in appearance, cause, and severity. When the physician is facing a rash, the history and physical examination of the patient are extremely important for the identification of the disease and its causal agent. There are various causes for a rash, which may be infectious, allergic, or rheumatologic, besides many others. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.10.019DOI Listing
October 2019

Using a Bayesian spatiotemporal model to identify the influencing factors and high-risk areas of hand, foot and mouth disease (HFMD) in Shenzhen.

PLoS Negl Trop Dis 2020 03 20;14(3):e0008085. Epub 2020 Mar 20.

Shenzhen Center for Disease Control and Prevention, Shenzhen, China.

Background: The epidemic of hand, foot, and mouth disease (HFMD) has become a severe public health problem in the world and has also brought a high economic and health burden. Furthermore, the prevalence of HFMD varies significantly among different locations. However, there have been few investigations of the effects of socioeconomic factors and air pollution factors on the incidence of HFMD. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112242PMC

Eczema coxsackium complicating allergic contact dermatitis during treatment with pimecrolimus 1% cream in an adult.

Authors:
Brandon L Adler

Contact Dermatitis 2020 Mar 19. Epub 2020 Mar 19.

Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, California.

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http://dx.doi.org/10.1111/cod.13527DOI Listing

Heparan sulfate attachment receptor is a major selection factor for attenuated enterovirus 71 mutants during cell culture adaptation.

PLoS Pathog 2020 Mar 18;16(3):e1008428. Epub 2020 Mar 18.

Neurovirology Project, Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

Enterovirus 71 (EV71) is a causative agent of hand, foot, and mouth disease (HFMD). However, this infection is sometimes associated with severe neurological complications. Identification of neurovirulence determinants is important to understand the pathogenesis of EV71. Read More

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http://dx.doi.org/10.1371/journal.ppat.1008428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105141PMC

Interaction analysis on transmissibility of main pathogens of hand, foot, and mouth disease: A modeling study (a STROBE-compliant article).

Medicine (Baltimore) 2020 Mar;99(11):e19286

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian Province, People's Republic of China.

Hand, foot, and mouth disease (HFMD) has spread widely and led to high disease burden in many countries. In this study, we aimed to analyze the interaction of the main pathogens of HFMD using a mathematical model.A dataset on reported HFMD cases was collected from April, 2009 to December, 2017 in Changsha City. Read More

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http://dx.doi.org/10.1097/MD.0000000000019286DOI Listing

Onychomadesis secondary to hand-foot-and-mouth disease: report of two cases.

An Bras Dermatol 2020 Mar - Apr;95(2):266-268. Epub 2020 Feb 20.

Faculdade de Medicina, Centro Universitário Católico Salesiano Auxilium, Unisalesiano, Araçatuba, SP, Brazil.

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http://dx.doi.org/10.1016/j.abd.2019.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175396PMC

[Summary of research in economic burden of hand, foot, and mouth disease in China].

Zhonghua Liu Xing Bing Xue Za Zhi 2020 Feb;41(2):273-279

Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing Municipal Research Center for Preventive Medicine, Beijing 100013, China.

Since 2010, the incidence of hand, foot, and mouth disease (HFMD) has ranked top in notifiable infectious disease in China, causing economic losses to many families and the society of China. This paper summarizes the related methods, results and problems systematically in the research of economic burden of HFMD in China to provide reference for the better estimation of the economic burden caused by HFMD. Many studies showed that HFMD, especially severe and fatal cases, had posed heavy economic burden on the society. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2020.02.023DOI Listing
February 2020

Safety and immunogenicity of an experimental live combination vaccine against enterovirus 71 and coxsackievirus A16 in rhesus monkeys.

Hum Vaccin Immunother 2020 Mar 11:1-9. Epub 2020 Mar 11.

The Institute of Medical Biology, Chinese Academic Medical Sciences & Peking Union Medical College, Kunming, China.

Enterovirus 71 (EV-A71) and Coxsackievirus A16 (CV-A16) are the two most common pathogens causing hand, foot, and mouth disease (HFMD). Previously, we obtained one candidate live attenuated strain each for EV-A71 and CV-A16; here, we evaluated the safety and immunogenicity of a combinedlive vaccine against EV-A71 and CV-A16 generated from these two candidate strains. Rhesus monkeys were intramuscularly treated with a live combinationvaccine against both EV-A71 and CV-A16 or with either vaccine alone. Read More

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http://dx.doi.org/10.1080/21645515.2019.1709353DOI Listing

Seasonal Distribution and Meteorological Factors Associated with Hand, Foot, and Mouth Disease among Children in Xi'an, Northwestern China.

Am J Trop Med Hyg 2020 Mar 9. Epub 2020 Mar 9.

Department of Epidemiology, Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Air Force Medical University, Xi'an, P. R. China.

Hand, foot, and mouth disease (HFMD) is a common infectious disease in the Asia-Pacific region that primarily affects children younger than 5 years. Previous studies have confirmed that the seasonal transmission of this disease is strongly related to meteorological factors, but the results are not consistent. In addition, the associations between weather conditions and HFMD in northwestern China have not been investigated. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0916DOI Listing

Exanthematous Eruptions in Children.

Pediatr Ann 2020 Mar;49(3):e116-e123

Childhood exanthems are commonly encountered by pediatricians in the hospital and the office. In the last several decades, we have seen a shift in the epidemiology of many of these diseases. After being deemed eliminated at the turn of 21st century, measles has experienced a resurgence secondary to falling vaccination rates, raising public health concerns. Read More

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http://dx.doi.org/10.3928/19382359-20200220-01DOI Listing

Transmission center and driving factors of hand, foot, and mouth disease in China: A combined analysis.

PLoS Negl Trop Dis 2020 03 9;14(3):e0008070. Epub 2020 Mar 9.

Department of Epidemiology and Biostatistics, School of Public Health, Fudan University, Shanghai, China.

Hand, foot, and mouth disease (HFMD) has become a major public health issue in China. The disease incidence varies substantially over time and across space. To understand the heterogeneity of HFMD transmission, we compare the spatiotemporal dynamics of HFMD in Qinghai and Shanghai by conducting combined analysis of epidemiological, wavelet time series, and mathematical methods to county-level data from 2009 to 2016. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062235PMC

Induction of SOCS Expression by EV71 Infection Promotes EV71 Replication.

Biomed Res Int 2020 19;2020:2430640. Epub 2020 Feb 19.

The First Hospital of Jilin University, Institute of Virology and AIDS Research & Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130021, China.

Enterovirus 71 (EV71) is the causative pathogen of hand, foot, and mouth disease (HFMD). However, no effective antiviral therapy is currently available. Some viruses could escape the host's innate immunity by upregulating suppressor of cytokine signaling (SOCS) proteins. Read More

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http://dx.doi.org/10.1155/2020/2430640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054758PMC
February 2020

The Epidemiological and Clinical Characteristics of Hand, Foot, and Mouth Disease in Hangzhou, China, 2016 to 2018.

Clin Pediatr (Phila) 2020 Mar 7:9922820910822. Epub 2020 Mar 7.

Hangzhou Children's Hospital, Hangzhou, Zhejiang, People's Republic of China.

Hand, foot, and mouth disease (HFMD) is most frequently caused by several serotypes of human enterovirus (EV) including Enterovirus 71 (EV-A71), coxsackievirus A16 (CV-A16), or other types of EV. The aim of this study was to determine the epidemiological characteristics of HFMD and to describe the epidemiologic characteristics of HFMD among severe and mild cases. We collected 4760 HFMD cases in Hangzhou from 2016 to 2018. Read More

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http://dx.doi.org/10.1177/0009922820910822DOI Listing

The Establishment of Infectious Clone and Single Round Infectious Particles for Coxsackievirus A10.

Virol Sin 2020 Mar 6. Epub 2020 Mar 6.

Shanghai Public Health Clinical Center and Institute of Biomedical Sciences, Fudan University, Shanghai, 201508, China.

Coxsackievirus A10 (CVA10) is one of the major etiological agents of hand, foot, and mouth disease. There are no vaccine and antiviral drugs for controlling CVA10 infection. Reverse genetic tools for CVA10 will benefit its mechanistic study and development of vaccines and antivirals. Read More

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http://dx.doi.org/10.1007/s12250-020-00198-2DOI Listing

Meteorological factors associated with hand, foot and mouth disease in a Central Highlands province in Viet Nam: an ecological study.

Western Pac Surveill Response J 2019 Oct-Dec;10(4):18-23. Epub 2019 Dec 13.

University of Medicine and Pharmacy, Ho Chi Minh City, Viet Nam.

Background: Hand, foot and mouth disease (HFMD) is a public health problem in Viet Nam, and studies have reported seasonal fluctuation in the occurrence of HFMD. This study sought to describe the occurrence of HFMD and its associated meteorological factors in Dak Lak province, Viet Nam.

Methods: Monthly data on HFMD cases were collected from all commune health stations in Dak Lak province from 2012 through 2013. Read More

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http://dx.doi.org/10.5365/wpsar.2017.8.1.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043093PMC
December 2019

Associations between ambient air pollution and daily incidence of pediatric hand, foot and mouth disease in Ningbo, 2014-2016: a distributed lag nonlinear model.

Epidemiol Infect 2020 Mar 4;148:e46. Epub 2020 Mar 4.

Ningbo Municipal Center for Disease Control and Prevention, Ningbo315010, China.

Hand, foot and mouth disease (HFMD) has high prevalence around the world, with serious consequences for children. Due to the long survival period of HFMD virus in ambient air, air pollutants may play a critical role in HFMD epidemics. We collected data on daily cases of HFMD among children aged 0-14 years in Ningbo City between 2014 and 2016. Read More

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http://dx.doi.org/10.1017/S0950268820000321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058833PMC

Seroprevalence of EV-A71 neutralizing antibodies following the 2011 epidemic in HCMC, Vietnam.

PLoS Negl Trop Dis 2020 03 3;14(3):e0008124. Epub 2020 Mar 3.

National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.

Enterovirus-A71 (EV-A71) cyclically causes hand-foot-mouth disease (HFMD) epidemics in Asian children. An EV-A71 epidemic occurred in Southern Vietnam in 2011, but its scale is not clear. We collected residual sera from non-HFMD Vietnamese inpatients in 2012-2013 to determine seroprevalence of EV-A71 neutralizing antibodies, and measured cross-reactive neutralizing antibody titers against three EV-A71 genogroups. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077839PMC

Diagnostic value of joint detection of white blood cells, blood glucose, and serum lactic acid for hand-foot-and-mouth disease.

J Biol Regul Homeost Agents 2020 Feb 29;34(1). Epub 2020 Feb 29.

Department of Infectious Diseases, Jinxiang Hospital Affiliated to Jining Medical College, Jining, China.

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http://dx.doi.org/10.23812/19-259-LDOI Listing
February 2020

TREM-1 activation is a potential key regulator in driving severe pathogenesis of enterovirus A71 infection.

Sci Rep 2020 Mar 2;10(1):3810. Epub 2020 Mar 2.

Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.

Hand, foot and mouth disease (HFMD), caused by enterovirus A71 (EV-A71), presents mild to severe disease, and sometimes fatal neurological and respiratory manifestations. However, reasons for the severe pathogenesis remain undefined. To investigate this, infection and viral kinetics of EV-A71 isolates from clinical disease (mild, moderate and severe) from Sarawak, Malaysia, were characterised in human rhabdomyosarcoma (RD), neuroblastoma (SH-SY5Y) and peripheral blood mononuclear cells (PBMCs). Read More

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http://dx.doi.org/10.1038/s41598-020-60761-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052206PMC
March 2020
5.078 Impact Factor

Coxsackievirus A6 Induces Necroptosis for Viral Production.

Front Microbiol 2020 4;11:42. Epub 2020 Feb 4.

Institute of Virology and AIDS Research, The First Hospital of Jilin University, Jilin University, Changchun, China.

Hand, foot, and mouth disease (HFMD) is a febrile exanthematous disease with typical or atypical symptoms. Typical HFMD is usually caused by enterovirus 71 (EV71) or coxsackievirus A16, while atypical HFMD is usually caused by coxsackievirus A6 (CA6). In recent years, worldwide outbreaks of CA6-associated HFMD have dramatically increased, although the pathogenic mechanism of CA6 is still unclear. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011610PMC
February 2020