2,367 results match your criteria Hand-Foot-and-Mouth Disease


A case report of a teenager with severe hand, foot, and mouth disease with brainstem encephalitis caused by enterovirus 71.

BMC Pediatr 2019 Feb 13;19(1):59. Epub 2019 Feb 13.

Intensive Care Unit, Key Medical Laboratory of Pediatrics, Chongqing Health Bureau, Ministry of Education; Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Background: Hand, foot, and mouth disease (HFMD) is an acute viral infection occurring mostly in infants and children. Enterovirus 71 (EV71) infection mostly occurs in children < 5 years of age. Severe cases, however, are usually encountered in children under the age of 3 years, and exceedingly rare in teenagers > 14 years and adults. Read More

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http://dx.doi.org/10.1186/s12887-019-1428-4DOI Listing
February 2019

Short-term effects of extreme meteorological factors on childhood hand, foot, and mouth disease reinfection in Hefei, China: A distributed lag non-linear analysis.

Sci Total Environ 2019 Feb 28;653:839-848. Epub 2018 Oct 28.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Shushan District, Hefei, Anhui 230032, China; Central Laboratory of Preventive Medicine, School of Public Health, Anhui Medical University, 81 Meishan Road, Shushan District, Hefei, Anhui 230032, China; Laboratory for environmental Toxicology, Anhui Medical University, 81 Meishan Road, Shushan District, Hefei, Anhui 230032, China. Electronic address:

Background: Hand, foot, and mouth disease (HFMD) is a major public health issue in China with a high burden of reinfection. Previous studies presented evidence of the relationship between meteorological factors and HFMD incidence, but no study examined the effects of extreme meteorological factors on HFMD reinfection.

Methods: Daily HFMD reinfection counts and meteorological data of Hefei city were collected from 2011 to 2016. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.10.349DOI Listing
February 2019

[Trend of epidemics and variation of pathogens of hand, foot and mouth disease in China: a dynamic series analysis, 2008-2017].

Authors:
J Zhang

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Feb;40(2):147-154

Division of Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

To understand the trend of epidemics and variation of pathogens on hand, foot and mouth diseases (HFMD) in China for setting up appropriate intervention measures. Data related to reported cases and outbreaks of HFMD from the National Notifiable Disease Surveillance Reporting System of China, 2008 to 2017, was collected and analyzed. Based on the geographical location and types of climate, the total 31 provinces, autonomous regions and municipalities in the mainland of China, were divided into seven regions: north-west, north, mid-north, east, mid-south, south, and south-west regions, with epidemic trends and variation of pathogens analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2019.02.005DOI Listing
February 2019
2 Reads

A potential therapeutic neutralization monoclonal antibody specifically against multi-coxsackievirus A16 strains challenge.

Hum Vaccin Immunother 2019 Feb 8. Epub 2019 Feb 8.

a National Institutes for Food and Drug Control , Beijing , China.

Coxsackievirus A16 (CA16) has caused worldwide epidemics of hand, foot and mouth disease (HFMD), particularly in infants and pre-school children. Currently, there are no vaccines or antiviral drugs available for CA16-associated disease. In this study, a CA16-specific monoclonal antibody (MAb) NA11F12 was derived with an epidemic CA16 strain (GenBank no. Read More

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https://www.tandfonline.com/doi/full/10.1080/21645515.2019.1
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http://dx.doi.org/10.1080/21645515.2019.1565266DOI Listing
February 2019
2 Reads

MRI reveals segmental distribution of enterovirus lesions in the central nervous system: a probable clinical evidence of retrograde axonal transport of EV-A71.

J Neurovirol 2019 Feb 7. Epub 2019 Feb 7.

Guangzou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, China.

Enterovirus 71 (EV-A71) is a major causative agent for hand, foot, and mouth disease (HFMD), especially severe HFMD characterized by neurologic involvement. The objective of this study is to investigate the relationship between the distribution of neurologic infection and the outcomes of severe HFMD. A total of 139 suspected severe HFMD cases (92 were confirmed as EV-A71 infection) underwent clinical and laboratory diagnosis as well as magnetic resonance imaging (MRI) scans of the nervous system. Read More

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http://dx.doi.org/10.1007/s13365-019-00724-3DOI Listing
February 2019
2 Reads

Five BoLA-DRB3 genotypes detected in Egyptian buffalo infected with Foot and Mouth disease virus serotype O.

J Genet Eng Biotechnol 2018 Dec 28;16(2):513-518. Epub 2018 Feb 28.

Virology Department, Veterinary Medicine College, Cairo University, Egypt.

Foot and Mouth disease (FMD) is a contagious disease leads to economically loss in livestock production all over the world. This serious disease is caused due to the infection of the animal with a single-stranded RNA virus (FMDV). This study aimed to investigate the genetic polymorphism of BoLA-DRB3 gene in Egyptian buffalo as a candidate genetic marker included in multi-factorial process of FMD resistance/susceptibility. Read More

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http://dx.doi.org/10.1016/j.jgeb.2018.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353717PMC
December 2018

Application of a combined model with seasonal autoregressive integrated moving average and support vector regression in forecasting hand-foot-mouth disease incidence in Wuhan, China.

Medicine (Baltimore) 2019 Feb;98(6):e14195

Wuhan Centers for Disease Prevention and Control.

Hand-foot-mouth disease (HFMD) is a serious public health problem with increasing cases and substantial financial burden in China, especially in Wuhan city. Hence, there is an urgent need to construct a model to predict the incidence of HFMD that could make the prevention and control of this disease more effective.The incidence data of HFMD of Wuhan city from January 2009 to December 2016 were used to fit a combined model with seasonal autoregressive integrated moving average (SARIMA) model and support vector regression (SVR) model. Read More

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http://dx.doi.org/10.1097/MD.0000000000014195DOI Listing
February 2019

Prenatal exposure to perfluoroalkyl substances is associated with lower hand, foot and mouth disease viruses antibody response in infancy: Findings from the Guangzhou Birth Cohort Study.

Sci Total Environ 2019 Jan 26;663:60-67. Epub 2019 Jan 26.

Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:

Background: Perfluoroalkyl substances (PFASs) are synthetic chemicals widely used in industry and for commercial products. Their immunomodulatory effects are a growing health concern in children. Hand, Foot and Mouth Disease (HFMD) is a common childhood viral infection, and increased incidence of which has parallel the rise in PFAS exposure in the Asia-Pacific region. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.325DOI Listing
January 2019
1 Read

Profiles of Human Enteroviruses Associated with Hand, Foot, and Mouth Disease in Nanjing, China.

Disaster Med Public Health Prep 2019 Feb 1:1-5. Epub 2019 Feb 1.

Institute of Pediatrics,Children's Hospital of Nanjing Medical University,Nanjing,Jiangsu,China.

Objective: Hand, foot, and mouth disease (HFMD) is a common infectious disease caused by a group of viruses. The causative viruses have changed over time, and there is a need for a more effective protective vaccine. In this study, we investigated the profiles of human enteroviruses that caused HFMD outbreaks in Nanjing in 2015, with the goal of guiding the future prevention and treatment of HFMD. Read More

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https://www.cambridge.org/core/product/identifier/S193578931
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http://dx.doi.org/10.1017/dmp.2018.155DOI Listing
February 2019
3 Reads

miR-545 promoted enterovirus 71 replication via directly targeting phosphatase and tensin homolog and tumor necrosis factor receptor-associated factor 6.

J Cell Physiol 2019 Jan 29. Epub 2019 Jan 29.

Basic Medicine College, Henan University of Chinese Medicine, Zhengzhou, Henan, China.

Enterovirus 71 (EV71) is a small, nonenveloped icosahedral RNA virus and is the predominant causative pathogen of hand-foot-and-mouth disease. Recently, microRNAs (miRNAs) are reported to play important roles in the pathogenesis of EV71 replication. This study investigated the role of miR-545 in the EV71 replication and explored the underlying molecular mechanisms. Read More

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http://dx.doi.org/10.1002/jcp.28222DOI Listing
January 2019
1 Read

Low frequency, weak MCP-1 secretion and exhausted immune status of peripheral monocytes were associated with progression of severe enterovirus A71-infected hand, foot, and mouth disease.

Clin Exp Immunol 2019 Jan 29. Epub 2019 Jan 29.

Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China, 100083.

A minority of hand, foot, and mouth disease (HFMD) caused by enterovirus A71 (EV-A71) results in severe neural complications. However, whether monocyte-mediated immunity is involved in the disease progression of HFMD remains unknown. 120 mild and 103 severe HFMD patients were recruited and ELISA, flow cytometry and transwell culture were performed in the study. Read More

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http://dx.doi.org/10.1111/cei.13267DOI Listing
January 2019
1 Read

Phylogenetic and antigenic analyses of coxsackievirus A6 isolates in Yamagata, Japan between 2001 and 2017.

Vaccine 2019 Feb 22;37(8):1109-1117. Epub 2019 Jan 22.

Department of Microbiology, Yamagata Prefectural Institute of Public Health, Yamagata 1-6-6, Yamagata 990-0031, Japan.

Although coxsackievirus A6 (CV-A6) is generally recognized as a causative agent of herpangina in children, CV-A6 infections globally emerged as a new and major cause of epidemic hand-foot-and-mouth-diseases (HFMDs) around 2008. To clarify the longitudinal epidemiology of CV-A6, we carried out sequence and phylogenetic analyses for the VP1 and partially for the VP4-3D regions as well as antigenic analysis using 115 CV-A6 isolates and 105 human sera in Yamagata, Japan between 2001 and 2017. Phylogenetic analysis revealed that CV-A6 isolates were clearly divided into two clusters; strains in circulation between 2001 and 2008 and those between 2010 and 2017. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.12.065DOI Listing
February 2019
3 Reads

Modelling and analysis of HFMD with the effects of vaccination, contaminated environments and quarantine in mainland China.

Math Biosci Eng 2018 Dec;16(1):474-500

Department of Mathematics, Nanjing University of Aeronautics and Astronautics, Nanjing, 210016, China.

Currently, hand, foot, and mouth disease (HFMD) is widespread in mainland China and seriously endangers the health of infants and young children. Recently in mainland China, preventing the spread of the disease has entailed vaccination, isolation measures, and virus clean-up in the contaminated environment. However, quantifying and evaluating the efficacy of these strategies on HFMD remains challenging, especially because relatively little research analyses the impact of EV71 vaccination for this disease. Read More

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http://dx.doi.org/10.3934/mbe.2019022DOI Listing
December 2018

Surveillance for severe hand, foot, and mouth disease from 2009 to 2015 in Jiangsu province: epidemiology, etiology, and disease burden.

BMC Infect Dis 2019 Jan 22;19(1):79. Epub 2019 Jan 22.

Medical School of Nanjing University, Nanjing, 210093, China.

Background: Severe hand, foot, and mouth disease (HFMD) is a common childhood illness caused by various enteroviruses. The disease has imposed increased burden on children younger than 5 years old. We aimed to determine the epidemiology, CNS complication, and etiology among severe HFMD patients, in Jiangsu, China. Read More

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http://dx.doi.org/10.1186/s12879-018-3659-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341624PMC
January 2019
1 Read

[Hospitalization burden of hand, foot and mouth disease in Anhua county of Hunan province, 2013-2016].

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Jan;40(1):79-83

Division of Infectious Disease, Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China; School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai 200032, China.

To estimate the serotype and age-specific hospitalization burden associated with hand, foot and mouth disease (HFMD) in Anhua county of Hunan province, between October 2013 and September 2016. We collected hospitalization records of HFMD patients from 6 virological surveillance hospitals, and reimbursement records through new rural cooperative medical system from 23 township health centers to estimate the age-specific hospitalization burden of HFMD in Anhua. Combined with the results of virological surveillance, the serotype-specific hospitalization burden of HFMD in Anhua, was estimated. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2019.01.016DOI Listing
January 2019
7 Reads

Possible long-term sequelae in hand, foot, and mouth disease caused by Coxsackievirus A6.

J Am Acad Dermatol 2019 Mar 17;80(3):804-806. Epub 2019 Jan 17.

Medical Microbiology, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183248
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http://dx.doi.org/10.1016/j.jaad.2018.08.034DOI Listing
March 2019
2 Reads

[Infantile atypical hand-foot-mouth disease with features of eczema herpeticum and acrodermatitis].

Arch Argent Pediatr 2019 02;117(1):e59-e62

Servicio de Pediatría, Hospital Juan Ramón Jiménez, Huelva. España.

Hand-foot-mouth disease can present atypically, including forms with more numerous lesions and/or morphologically different from the classic presentation. It may even mimic other viral diseases. We present the case of a 2-year-old child previously diagnosed with atopic dermatitis, who presented with papules and umbilicated vesicles affecting the perioral area and limbs, predominantly in pressure areas, as well as in areas with previous atopic lesions. Read More

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http://dx.doi.org/10.5546/aap.2019.e59DOI Listing
February 2019
13 Reads

Coxsackievirus A10 atomic structure facilitating the discovery of a broad-spectrum inhibitor against human enteroviruses.

Cell Discov 2019 15;5. Epub 2019 Jan 15.

2CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.

Coxsackievirus A10 (CV-A10) belongs to the species A and is a causative agent of hand, foot, and mouth disease. Here we present cryo-EM structures of CV-A10 mature virion and native empty particle (NEP) at 2.84 and 3. Read More

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http://www.nature.com/articles/s41421-018-0073-7
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http://dx.doi.org/10.1038/s41421-018-0073-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331555PMC
January 2019
9 Reads

The Effectiveness of Different Doses of Intravenous Immunoglobulin on Severe Hand, Foot and Mouth Disease: A Meta-Analysis.

Med Princ Pract 2019 Jan 15. Epub 2019 Jan 15.

Objective: To conduct a meta-analysis of evidence from randomized controlled trails (RCTs) of different doses of Intravenous Immunoglobulin (IVIG) in children with severe hand, foot and mouth disease (HFMD) to provide the scientific basis for clinical practice.

Methods: A search of PubMed-Medline, CNKI, Wanfang, and VIP database (until 30 June 2017) was performed and Software RevMan5.3 was used to evaluate the effect of different doses of IVIG on HFMD in RCTs, We used random effects models (or fixed effects models) and generic inverse variance methods to process quantitative data, followed by a leave-one-out method for sensitivity analysis. Read More

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https://www.karger.com/Article/FullText/496926
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http://dx.doi.org/10.1159/000496926DOI Listing
January 2019
5 Reads
1.113 Impact Factor

Longitudinal study on enterovirus A71 and coxsackievirus A16 genotype/subgenotype replacements in hand, foot and mouth disease patients in Thailand, 2000-2017.

Int J Infect Dis 2019 Jan 11;80:84-91. Epub 2019 Jan 11.

Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok-noi, Bangkok 10700, Thailand; Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Nakhon Pathom 73170, Thailand. Electronic address:

Background: Enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16) are the major causative agents of hand, foot and mouth disease (HFMD) worldwide, particularly in the Asia-Pacific region. Several strains have emerged, circulated, and faded out over time in recent decades. This study investigated the EV-A71 and CV-A16 circulating strains and replacement of genotypes/subgenotypes in Thailand during the years 2000-2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712193001
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http://dx.doi.org/10.1016/j.ijid.2018.12.020DOI Listing
January 2019
2 Reads
2.330 Impact Factor

Acute gingivostomatitis in children: Epidemiology in the emergency department, pain, and use of codeine before its restriction.

Arch Pediatr 2019 Feb 11;26(2):80-85. Epub 2019 Jan 11.

Service des urgences pédiatriques, hôpital Armand-Trousseau, AP-HP, 26, avenue du Dr-Arnold-Netter, 75012 Paris, France; Inserm U1153, université Pierre-et-Marie-Curie, Paris VI, 75005 Paris, France.

Acute gingivostomatitis is relatively frequent in children; of viral origin, its diagnosis is usually straightforward. Acute gingivostomatitis is very painful and for many years, codeine, whose use was restricted in 2013, was widely employed in this context. The aim of this study was to ascertain the prevalence of acute stomatitis in pediatric emergency care, to evaluate the pain caused by stomatitis, and to determine the analgesic resources deployed both in the emergency department and at discharge, over the 5-year period preceding restriction of the use of codeine. Read More

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http://dx.doi.org/10.1016/j.arcped.2018.11.004DOI Listing
February 2019

Analysis of Epidemiological Characteristics of Notifiable Diseases Reported in Children Aged 0⁻14 Years from 2008 to 2017 in Zhejiang Province, China.

Int J Environ Res Public Health 2019 Jan 9;16(2). Epub 2019 Jan 9.

Department of Public Health Surveillance & Advisory, Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Binjiang District, Hangzhou 310051, China.

This study aims to learn the characteristics of morbidity and mortality of notifiable diseases reported in children aged 0⁻14 years in Zhejiang Province in 2008⁻2017. We collated data from the China Information System for Disease Control and Prevention in Zhejiang province between 1 January 2008 and 31 December 2017 of children aged 0⁻14 years. From 2008 to 2017, a total of 32 types and 1,994,740 cases of notifiable diseases were reported in children aged 0⁻14 years, including 266 deaths in Zhejiang Province. Read More

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http://www.mdpi.com/1660-4601/16/2/168
Publisher Site
http://dx.doi.org/10.3390/ijerph16020168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352024PMC
January 2019
6 Reads

Ehlers-Danlos syndrome with infective endocarditis: A case report with literature review.

IDCases 2019 29;15:e00484. Epub 2018 Dec 29.

Department of Pulmonary and Critical Care Medicine, University of Tennessee Graduate School of Medicine, Knoxville, USA.

We report a patient with Ehlers-Danlos syndrome and mitral valve infective endocarditis. The case was complicated due to multiorgan involvement and initially diagnosed as hand-foot-and-mouth disease. The patient was transferred to our hospital with cerebral septic emboli and bilateral lower extremity emboli requiring early surgery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22142509183022
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http://dx.doi.org/10.1016/j.idcr.2018.e00484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322054PMC
December 2018
8 Reads

Interactions between climate factors and air pollution on daily HFMD cases: A time series study in Guangdong, China.

Sci Total Environ 2019 Mar 27;656:1358-1364. Epub 2018 Nov 27.

Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:

Background: Prior studies have shown that climate factors and air pollution are associated with hand, foot, and mouth disease (HFMD) epidemics. However, the interaction between air pollution and climate factors remains unknown.

Methods: Daily HFMD counts from 2009 through 2012 in Guangdong were collected. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697183474
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http://dx.doi.org/10.1016/j.scitotenv.2018.11.391DOI Listing
March 2019
1 Read

Development of an efficient neutralization assay for Coxsackievirus A10.

Appl Microbiol Biotechnol 2019 Jan 8. Epub 2019 Jan 8.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, 361102, People's Republic of China.

Coxsackievirus A10 (CVA10) recently has become one of the major pathogens of hand, foot, and mouth disease (HFMD) in children worldwide, but no cure or vaccine against CVA10 is available yet. Serological evaluation of herd immunity to CVA10 will promote the development of vaccine. The traditional neutralization assay based on inhibition of cytopathic effect (Nt-CPE) is a common method for measuring neutralizing antibody titer against CVA10, which is time-consuming and labor-intensive. Read More

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http://link.springer.com/10.1007/s00253-018-09598-7
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http://dx.doi.org/10.1007/s00253-018-09598-7DOI Listing
January 2019
4 Reads

Epidemic pattern of hand-foot-and-mouth disease in Xi'an, China from 2008 through 2015.

BMC Infect Dis 2019 Jan 7;19(1):19. Epub 2019 Jan 7.

Institute of Endemic Diseases of School of Public Health, Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Xi'an Jiaotong University, No.76, YanTa West RD, Xi'an, 710061, Shaanxi, China.

Background: Hand, foot and mouth disease (HFMD) is an infectious disease caused by enteroviruses that has a severely impair for those high incidence countries such as China.The current study aimed to investigate the epidemic pattern of HFMD by time and region in Northwestern China.

Methods: All reported HFMD cases from 2008 to 2015 were collected from local Disease Control and Prevention. Read More

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http://dx.doi.org/10.1186/s12879-018-3624-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322279PMC
January 2019
2 Reads
2.613 Impact Factor

Ongoing change of severe hand, foot, and mouth disease pathogens in Yunnan, China, 2012 to 2016.

J Med Virol 2019 Jan 6. Epub 2019 Jan 6.

The Department of Medical Genetics, Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College, Kunming, China.

Hand, foot, and mouth disease (HFMD) is a common infectious disease caused by enteroviruses (EVs). In this study, a total of 341 children with serious HFMD were admitted to a pediatric hospital in Yunnan, China in 2012 to 2016. EVs were detected in 283 specimens (83. Read More

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http://doi.wiley.com/10.1002/jmv.25393
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http://dx.doi.org/10.1002/jmv.25393DOI Listing
January 2019
11 Reads

The untranslated regions of EV-A71 contribute to its pathogenicity and virulence.

Virus Res 2019 Jan 3;263:55-63. Epub 2019 Jan 3.

Department of Microbiological Laboratory Technology, School of Public Health, Shandong University, Jinan, 250012 Shandong Province, China; Key Laboratory for the Prevention and Control of Infectious Diseases (Key Laboratory of China's "13th Five-Year", Shandong University), China. Electronic address:

Enterovirus A71 (EV-A71) is known for its manifestation as hand foot and mouth disease (HFMD), which has caused countless large-scale epidemic outbreaks throughout the world. However, the molecular pathogenesis of EV-A71 infection is still elusive. Previous studies found that the biological characteristics of a mild EV-A71 strain (SDLY1) and a severe EV-A71 strain (SDLY107) are significantly different, and sequence analysis showed that there are several differences in nucleotide sites of UTRs (88 nt, 123 nt, 143 nt, 154 nt, 187 nt, 241 nt, 243 nt, 253 nt, 291 nt, 438 nt, 440 nt, 571 nt, 579 nt, 602 nt, 658 nt, 664 nt, 690 nt, 696 nt, 7328 nt, 7335 nt, 7367 nt, and 7395 nt). Read More

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http://dx.doi.org/10.1016/j.virusres.2018.12.019DOI Listing
January 2019
1 Read

High permissiveness for genetic exchanges between enteroviruses of species A, including enterovirus 71, favours evolution through intertypic recombination in Madagascar.

J Virol 2019 Jan 2. Epub 2019 Jan 2.

Institut Pasteur, Unité de Biologie des Virus Entériques, Paris, France

Human enteroviruses of species A (EV-A) are the leading cause of hand-foot-and-mouth disease (HFMD). EV-A71 is frequently implicated in HFMD outbreaks and can also cause severe neurological manifestations. We investigated the molecular epidemiological processes at work and the contribution of genetic recombination to the evolutionary history of EV-A in Madagascar, focusing on the recently described EV-A71 genogroup F in particular. Read More

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http://dx.doi.org/10.1128/JVI.01667-18DOI Listing
January 2019
2 Reads

Echovirus plays a major role in natural recombination in the coxsackievirus B group.

Arch Virol 2019 Jan 1. Epub 2019 Jan 1.

Medical College, Jiangsu University, 301 Xuefu road, Zhenjiang, 212013, People's Republic of China.

Coxsakievirus (CV) B4, CVB5, and CVA9 belong to the species Enterovirus B. These viruses can cause viral encephalitis, aseptic meningitis, pancreatitis, flaccid paralysis, dilated myocarditis, and hand, foot, and mouth disease (HFMD). In order to analyze the evolution of CVB4, CVB5, and CVA9, we analyzed all of the available genome sequences of Enterovirus B (EVB) isolates and found that there were 12 putative recombination events that produced CVB4, 13 putative recombination events that produced CVB5, and 10 putative recombination events that produced CVA9. Read More

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http://dx.doi.org/10.1007/s00705-018-4114-1DOI Listing
January 2019
2 Reads

Spiramycin and azithromycin, safe for children administration, exert anti-viral activity against enterovirus A71 in vitro and in vivo.

Int J Antimicrob Agents 2018 Dec 29. Epub 2018 Dec 29.

Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China; Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou 510080, China; Meizhou People's Hospital, Meizhou 514031, China. Electronic address:

Hand-foot-mouth disease (HFMD) is a common viral disease in young children, mainly caused by enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16). Specific anti-viral agents are not commercially available yet. Here we report that the macrolide antibiotics spiramycin (SPM) and azithromycin (AZM) possess anti-viral activities against EV-A71 and CV-A16. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09248579183037
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http://dx.doi.org/10.1016/j.ijantimicag.2018.12.009DOI Listing
December 2018
9 Reads

Viperin Inhibits Enterovirus A71 Replication by Interacting with Viral 2C Protein.

Viruses 2018 Dec 26;11(1). Epub 2018 Dec 26.

CAS Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.

Enterovirus A71 (EVA71) is a human enterovirus belonging to the Picornaviridae family and mostly causes hand-foot-and-mouth disease in infants. Viperin is an important interferon-stimulated gene with a broad antiviral activity against various viruses. However, the effect of viperin on human enteroviruses and the interaction mechanism between EVA71 and viperin remains elusive. Read More

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http://www.mdpi.com/1999-4915/11/1/13
Publisher Site
http://dx.doi.org/10.3390/v11010013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357129PMC
December 2018
17 Reads
3.279 Impact Factor

Heat shock protein 70 as a supplementary receptor facilitates enterovirus 71 infections in vitro.

Microb Pathog 2018 Dec 21;128:106-111. Epub 2018 Dec 21.

Center Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China. Electronic address:

As one of the major causative agents of hand, foot and mouth disease (HFMD), enterovirus 71 (EV71) is a small, non-enveloped positive stranded RNA virus. Children suffering EV71 infection may cause severe symptoms including neurological complications, pulmonary edema and aseptic meningitis. EV71 is a neurotropic virus and it can cause the damage of nervous cells, cytokine storm and toxic substance. Read More

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http://dx.doi.org/10.1016/j.micpath.2018.12.032DOI Listing
December 2018
2 Reads

Short-term exposure to sulfur dioxide and the risk of childhood hand, foot, and mouth disease during different seasons in Hefei, China.

Sci Total Environ 2019 Mar 2;658:116-121. Epub 2018 Dec 2.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui 230032, China. Electronic address:

Background: Sulfur dioxide (SO) is an important component of air pollution, adversely impacting human health worldwide. This study aimed to examine the association between short-term exposure to SO and childhood hand, foot, and mouth disease (HFMD) in Hefei, China.

Methods: A Poisson generalized additive model (GAM) combining the time-series regression analyses was used to fit the SO-HFMD association. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697183483
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http://dx.doi.org/10.1016/j.scitotenv.2018.11.481DOI Listing
March 2019
1 Read

The inactivation of the non-enveloped enterovirus 71 (EV71) by a novel disinfectant gel formulation for topical use.

Drug Dev Ind Pharm 2018 Dec 21. Epub 2018 Dec 21.

a Tianjin International Joint Academy of Biomedicine , No.220 Dongting Road, the Tianjin Economic-Technological Development Area (TEDA) , Tianjin , China (PRC) .

Background: Hand-Foot-Mouth Disease may cause severe central nervous system complications and even death, that induced mainly by enterovirus 71 (EV71), which is a non-enveloped virus. Inactivation of the EV71on hands could effectively inhibit the transmission. However, the inactivations of the EV71by conventional disinfectants including the alcohols are poor, due to the high stability of the EV71. Read More

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http://dx.doi.org/10.1080/03639045.2018.1562464DOI Listing
December 2018
3 Reads

Effect of hand washing and personal hygiene on hand food mouth disease: A community intervention study.

Medicine (Baltimore) 2018 Dec;97(51):e13144

Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.

There are no specific treatment drugs and vaccine for Hand Foot and Mouth Disease (HFMD). Taking effective preventive measures is particularly important for control of HFMD infection. The objective of this study is to evaluate the effect of intervention of intensive education on hand hygiene on HFMD. Read More

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http://dx.doi.org/10.1097/MD.0000000000013144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320109PMC
December 2018

[Surveillance data on notifiable infectious diseases among students aged 6-22 years in China, 2011-2016].

Zhonghua Liu Xing Bing Xue Za Zhi 2018 Dec;39(12):1589-1595

Division of Infectious Disease Control and Prevention, Key Laboratory of Surveillance and Early Warning on Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

To analyze the epidemiological characteristics of notifiable infectious diseases among Chinese students from 2011 to 2016 and to provide reference for the effective prevention and control programs on infectious disease among students. Both morbidity and mortality of notifiable infectious diseases among Chinese students aged 6-22 years from 2011 to 2016 were analyzed, with main characteristics of the disease described. During 2011 to 2016, morbidities of Categories A, B and C infectious diseases among the Chinese students aged 6-22 years showed a decreasing trend, from 248. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2018.12.010DOI Listing
December 2018
7 Reads

[ECMO support in a child with cardiogenic shock due to Kingella Kingae endocarditis].

Rev Chil Pediatr 2018 Oct;89(5):644-649

Unidad ECMO, Clínica Las Condes, Chile.

Introduction: Endocarditis is a rare disease in children, especially in those without previous heart disease, and Kingella Kingae (KK) is rarely identified as the cause. Extracorporeal membrane oxyge nation (ECMO) is a support for both heart and respiratory failure.

Objective: To report the first case of infectious endocarditis (IE) due to KK which required ECMO support secondary to refractory cardiogenic shock. Read More

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http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.4067/S0370-41062018005000804DOI Listing
October 2018
13 Reads

Hand-foot-and-mouth disease caused by coxsackievirus A6 on the rise.

Cutis 2018 Nov;102(5):353-356

University of Texas Medical School at Houston, USA.

Hand-foot-and-mouth disease (HFMD) is a viral illness caused most commonly by coxsackievirus A16 (CVA16) and enterovirus 71 (EV71). The disease mainly affects pediatric populations younger than 5 years and is characterized by lesions of the oral mucosa, palms, and soles, lasting for 7 to 10 days. In recent years, CVA6 has become a major cause of HFMD outbreaks in the United States and worldwide. Read More

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November 2018
3 Reads

Toll-Like Receptor 3 Is Involved in Detection of Enterovirus A71 Infection and Targeted by Viral 2A Protease.

Viruses 2018 12 5;10(12). Epub 2018 Dec 5.

Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.

Enterovirus A71 (EV-A71) has emerged as a major pathogen causing hand, foot, and mouth disease, as well as neurological disorders. The host immune response affects the outcomes of EV-A71 infection, leading to either resolution or disease progression. However, the mechanisms of how the mammalian innate immune system detects EV-A71 infection to elicit antiviral immunity remain elusive. Read More

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http://dx.doi.org/10.3390/v10120689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315976PMC
December 2018
2 Reads

Hand, Foot, and Mouth Disease.

JAMA 2018 12;320(23):2492

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http://dx.doi.org/10.1001/jama.2018.17288DOI Listing
December 2018

Casting New Light on Hand-Foot-and-Mouth Disease.

J Pediatr 2018 Dec 14. Epub 2018 Dec 14.

Department of Dermatology and Pediatrics Columbia University New York, New York.

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http://dx.doi.org/10.1016/j.jpeds.2018.11.032DOI Listing
December 2018

Recent Progress on Functional Genomics Research of Enterovirus 71.

Virol Sin 2018 Dec 14. Epub 2018 Dec 14.

Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.

Enterovirus 71 (EV71) is one of the main pathogens that causes hand-foot-and-mouth disease (HFMD). HFMD caused by EV71 infection is mostly self-limited; however, some infections can cause severe neurological diseases, such as aseptic meningitis, brain stem encephalitis, and even death. There are still no effective clinical drugs used for the prevention and treatment of HFMD. Read More

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http://link.springer.com/10.1007/s12250-018-0071-9
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http://dx.doi.org/10.1007/s12250-018-0071-9DOI Listing
December 2018
9 Reads

Complete genome analysis demonstrates multiple introductions of enterovirus 71 and coxsackievirus A16 recombinant strains into Thailand during the past decade.

Emerg Microbes Infect 2018 Dec 14;7(1):214. Epub 2018 Dec 14.

Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Nakhon, Pathom, 73170, Thailand.

Hand, foot, and mouth disease (HFMD) caused by enteroviruses remains a public health threat, particularly in the Asia-Pacific region during the past two decades. Moreover, the introduction of multiple subgenotypes and the emergence of recombinant viruses is of epidemiological importance. Based on either the full genome or VP1 sequences, 32 enteroviruses (30 from HFMD patients, 1 from an encephalitic patient, and 1 from an asymptomatic contact case) isolated in Thailand between 2006 and 2014 were identified as 25 enterovirus 71 (EV71) isolates (comprising 20 B5, 1 C2, 2 C4a, and 2 C4b subgenotypes) and 7 coxsackievirus A16 (CA16) isolates (comprising 6 B1a and 1 B1b subgenotypes). Read More

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http://www.nature.com/articles/s41426-018-0215-x
Publisher Site
http://dx.doi.org/10.1038/s41426-018-0215-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294798PMC
December 2018
1 Read

Clinical and aetiological study of hand, foot and mouth disease in southern Vietnam, 2013-2015: Inpatients and outpatients.

Int J Infect Dis 2018 Dec 11;80:1-9. Epub 2018 Dec 11.

Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Background: Hand, foot and mouth disease (HFMD) has been associated with large outbreaks among young children in the Asia-Pacific Region since 1997, including cases of severe illness and death. Severe illness is often associated with enterovirus A71 (EV-A71). Vietnam experienced a large sustained outbreak of 200000 hospitalized cases and over 200 deaths in 2011-12, the large majority occurring in southern Vietnam. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.12.004DOI Listing
December 2018
1 Read
2.330 Impact Factor

Spatiotemporal decomposition and risk determinants of hand, foot and mouth disease in Henan, China.

Sci Total Environ 2019 Mar 5;657:509-516. Epub 2018 Dec 5.

China National Center for Food Safety Risk Assessment, Beijing 100022, China. Electronic address:

Hand, foot and mouth disease (HFMD) remains an increasing public health concern. The spatiotemporal variation of HFMD can be represented from multiple-perspectives, and it may be driven by different dominant factors. In this study, the HFMD cases in children under the age of five years in each county in Henan province, China, from 2009 to 2013 were assessed to explore the integrative spatiotemporal patterns of HFMD and investigate their driving factors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697183487
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http://dx.doi.org/10.1016/j.scitotenv.2018.12.039DOI Listing
March 2019
12 Reads
4.099 Impact Factor

Population based hospitalization burden of laboratory-confirmed hand, foot and mouth disease caused by multiple enterovirus serotypes in Southern China.

PLoS One 2018 13;13(12):e0203792. Epub 2018 Dec 13.

Division of Infectious Disease, Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China.

Background: Hand, foot and mouth disease (HFMD) is spread widely across Asia, and the hospitalization burden is currently not well understood. Here, we estimated serotype-specific and age-specific hospitalization rates of HFMD in Southern China.

Methods: We enrolled pediatric HFMD patients admitted to 3/3 county-level hospitals, and 3/23 township-level hospitals in Anhua county, Hunan (CN). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203792PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292616PMC
December 2018
10 Reads
3.234 Impact Factor

Screening and Identification of Linear B Cell Epitopes Within the Nonstructural Proteins of Enterovirus 71.

Viral Immunol 2018 Dec 6. Epub 2018 Dec 6.

Department of Laboratory Medicine, School of Medicine, Shaoxing University , Shaoxing, P.R. China .

Enterovirus 71 (EV-A71) has attracted widespread attention in the past decade because of its higher neurotropicity in addition to causing hand-foot-and-mouth disease (HFMD). Mapping epitopes of viral proteins may promote our understanding of antiviral humoral immunity, and is useful for clinical application. In this study, the linear B cell epitopes within nonstructural proteins of EV-A71 were identified using bioinformatics methods combined with peptide enzyme-linked immunosorbent assay (ELISA). Read More

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http://dx.doi.org/10.1089/vim.2018.0125DOI Listing
December 2018
2 Reads
1.636 Impact Factor

Molecular epidemiology and clinical features of hand, foot and mouth disease in northern Thailand in 2016: a prospective cohort study.

BMC Infect Dis 2018 Dec 6;18(1):630. Epub 2018 Dec 6.

School of Health Science Research, Mae Fah Luang University, 333 Mo.1 Tasud Subdistrict, Muang District, Chiang Rai, Chiang Rai Province, 57100, Thailand.

Background: Hand, foot and mouth disease (HFMD) is a major communicable disease in children ≤6 years old, particularly in several countries in the Asia-Pacific Region, including Thailand. HFMD impacts public health and the economy, especially in northern Thailand.

Methods: A prospective cohort study was conducted to estimate the incidence rate and to identify the serotype and clinical features of HFMD among children in northern Thailand. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
Publisher Site
http://dx.doi.org/10.1186/s12879-018-3560-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282397PMC
December 2018
5 Reads

Case of hand, foot and mouth disease with vesicular Koebner phenomenon on the ankles caused by Coxsackievirus A6 in an adult.

J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.

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http://dx.doi.org/10.1111/1346-8138.14723DOI Listing
December 2018
1 Read